Name stringlengths 14 548 | Synonym stringlengths 14 790 ⌀ | CAS RN stringlengths 7 12 | Y int64 0 1 | Detailed Page stringlengths 57 580 | Evidence stringlengths 40 2.31k ⌀ | OECD TG 404 stringclasses 1
value | Data Source stringclasses 34
values | Frequency int64 1 6 | SMILES stringlengths 2 255 | SMILES URL stringlengths 45 101 | SMILES Source stringclasses 4
values | Canonical SMILES stringlengths 2 248 | Split stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NZ_CCID:
2-Ethylhexyl dihydrogen phosphate | NZ_CCID:
Phosphoric acid, mono(2-ethylhexyl)ester | 1070-03-7 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3281E22-D4D1-4A1F-96F3-9985FD308231 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CCCCC(CC)COP(=O)(O)O | https://pubchem.ncbi.nlm.nih.gov/compound/14050 | PubChem | CCCCC(CC)COP(=O)(O)O | Train |
JP_CHRIP:
Acrylaldehyde
KR_NCIS:
Acrolein
NZ_CCID:
Acrolein
US_HSDB:
ACROLEIN | JP_CHRIP:
2-Propen-1-al
2-Propenal
Acrolein
acrolein (synonym:acrylaldehyde)
acrylaldehyde (synonym:acrolein)
Acrylic aldehyde
Prop-2-enal
KR_NCIS:
2-Propenal
NZ_CCID:
2-Propenal, Acraldehyde, Acrylaldehyde, Acrylic aldehyde, Allyl aldehyde, Aqualin, Ethylene aldehyde, Prop-2-en-1-al | 107-02-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2004.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B07E1-8729-43BF-B83A-41008FE6788B
US_HSDB: https://pubchem.ncbi.n... | JP_CHRIP:
【分類根拠】
（１）、（２）より、区分1とした。
【根拠データ】
（１）本物質0.01～10％溶液をボランティアの皮膚に適用したパッチテストにおいて、0.01％溶液を適用した8名及び0.1％溶液を適用した10名では陽性反応はみられなかった。1％溶液を適用した48名では12.5％（6/48名）が陽性反応を示し、うち4名で水疱形成を伴う重度の浮腫、2名で紅斑と重度浮腫がみられた。10％溶液では全例（20/20名）の皮膚に水疱、壊死、炎症細胞の浸潤、乳頭状の水腫がみられたとの報告がある（NITE 初期 リスク評価書 (2007)、ECHA RAC Opinion (2012)、CLH Report (2011)、EU... | null | JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 4 | C=CC=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.045B | J-GLOBAL | C=CC=O | Train |
EU_REACH:
4-({6-chloro-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile | null | 1070377-34-2 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25836/7/4/2/?documentUUID=a53cfa2c-052b-454b-b56b-9105893c8cf7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC(=CC(=C1OC2=CC(=NC(=N2)NC3=CC=C(C=C3)C#N)Cl)C)C#N | https://pubchem.ncbi.nlm.nih.gov/compound/50914946 | PubChem | Cc1cc(C#N)cc(C)c1Oc1cc(Cl)nc(Nc2ccc(C#N)cc2)n1 | Train |
EU_REACH:
ethyl 6,8-dichlorooctanoate | null | 1070-64-0 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31429/7/4/2/?documentUUID=f951c697-40c9-420a-abc9-853d27afa43c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)CCCCC(CCCl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/14053 | PubChem | CCOC(=O)CCCCC(Cl)CCCl | Train |
NZ_CCID:
1,4-Butanediol diacrylate | null | 1070-70-8 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A1F7A1E7-05D3-4A6B-80EA-FDE3BDD1D11A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C=CC(=O)OCCCCOC(=O)C=C | https://pubchem.ncbi.nlm.nih.gov/compound/70613 | PubChem | C=CC(=O)OCCCCOC(=O)C=C | Train |
NZ_CCID:
3,3-Dimethylbutyric acid | null | 1070-83-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2844A019-798A-44CB-A2BF-E83D5F4C2D18 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CC(C)(C)CC(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/14057 | PubChem | CC(C)(C)CC(=O)O | Train |
JP_CHRIP:
Propylamine
NZ_CCID:
1-Propanamine | JP_CHRIP:
1-Aminopropane
n-Propylamine
Propanamine
NZ_CCID:
1-Aminopropane, Monopropylamine, Propylamine | 107-10-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0047e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA72A93B-D31E-4C3F-B537-DF250ECC1B3A | JP_CHRIP:
Based on a report of grade 6 (maximum grade 8) in rabbit test (PATTY (5th, 2001)), a report of "contact can severely irritate and burn the skin" (HSFS (2001)), and information of pH 12.6 (20 degC, 100 g/L) (GESTIS (access on Aug. 2009)), the substance was classified into Category 1. As relevant information, a... | null | JP_CHRIP, NZ_CCID | 2 | CCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.052E | J-GLOBAL | CCCN | Train |
JP_CHRIP:
3-Amino-1-propene; Allylamine | JP_CHRIP:
2-Propenylamine
3-Aminopropene
monoallylamine | 107-11-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2018e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified in Category 1. Besides, since new data were obtained, the category was changed.
[Evidence Data]
(1) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, after 3 or 60 minutes of exposure,... | null | JP_CHRIP | 1 | NCC=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.053C | J-GLOBAL | C=CCN | Train |
NZ_CCID:
Phosphorylethanolamine | NZ_CCID:
2-Aminoethyl dihydrogen phosphate, Colamine phosphate, Ethanol, 2-amino-, phosphate, Ethanolamine O-phosphate, Ethanolamine phosphate, Mono(2-aminoethyl) phosphate, O-Phosphoethanolamine, O-Phosphorylethanolamine, Phosphoethanolamine, Phosphonoethanolamine, Phosphoric acid, 2-aminoethyl phenyl ester, Phosphory... | 1071-23-4 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA18F847-CF01-40E1-82B5-58941D64F351 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Chemwatch]
Eye Irritation
R PHRASE: R 41 [Chemwatch] | null | NZ_CCID | 1 | C(COP(=O)(O)O)N | https://pubchem.ncbi.nlm.nih.gov/compound/1015 | PubChem | NCCOP(=O)(O)O | Train |
JP_CHRIP:
Ethylenediamine
KR_NCIS:
1,2-Ethanediamine; Ethylenediamine
NZ_CCID:
Ethylenediamine | JP_CHRIP:
1,2-Diaminoehtane
1,2-Diaminoethane
1,2-Ethanediamine
1,2-Ethylenediamine
Dimethylenediamine
Ethane-1,2-diamine
Ethylene diamine
NZ_CCID:
1,2-Diaminoethane, 1,2-Ethanediamine, 1,2-Ethylenediamine, Dimethylenediamine, Ethylendiamine | 107-15-3 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2020e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F417F0FB-94DF-4EFF-8B2B-07BA946DB39C | JP_CHRIP:
It is described that in a test in which undiluted this substance was applied to rabbits for 1 minute, there were severe inflammation and necrosis at the application site, and some animals had scars that reached the muscle (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)), and in a test by ... | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | NCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.057F | J-GLOBAL | NCCN | Train |
JP_CHRIP:
N-(phosphonomethyl)glycine [glyphosate] | JP_CHRIP:
Glycine, N-(phosphonomethyl)-
Glyphosate
N-(Phosphonomethyl)glycine | 1071-83-6 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0095e.html | JP_CHRIP:
It is reported that in a test using rabbits (US EPA guidelines or OECD TG 404, GLP), slight irritation was observed and the score is 0.8. It is reported that in 4 other tests using rabbits (US EPA guidelines or OECD TG 404, GLP), no irritation was observed in any of these tests (EHC 159 (1994), JMPR (2004)).
... | Provided | JP_CHRIP | 1 | OC(=O)CNCP(=O)(O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.359F | J-GLOBAL | O=C(O)CNCP(=O)(O)O | Train |
JP_CHRIP:
Hexanedioic acid, 1,6-dihydrazide | JP_CHRIP:
adipic dihydrazide
adipohydrazide
Hexanedioic acid, dihydrazide | 1071-93-8 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0019e.html | JP_CHRIP:
[Rationale for the Classification]
It was classified as "Not classified" from (1).
[Evidence Data]
(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, ede... | Provided | JP_CHRIP | 1 | NNC(=O)CCCCC(=O)NN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.606D | J-GLOBAL | NNC(=O)CCCCC(=O)NN | Train |
JP_CHRIP:
2-Propyn-1-ol
KR_NCIS:
2-Propyn-1-ol
NZ_CCID:
2-Propyn-1-ol | JP_CHRIP:
prop-2-yn-1-ol (synonym:2-Propyn-1-ol)
KR_NCIS:
Propargyl alcohol; 1-propyne-3-ol; Propynyl alcohol; Ethynlcarbinol; 2-propynl alcohol; 2-propynol; 3-propynol
NZ_CCID:
1-Hydroxy-2-propyne, 1-Propyn-3-ol, 2-Propynyl alcohol, 3-Hydroxy-1-propyne, 3-Propynol, Ethynyl carbinol, Ethynylcarbinol, Propynyl alcohol | 107-19-7 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2005e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4FE7AA73-DB8C-45CA-AEB8-E9BA07C09AFF | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1B.
[Evidence Data]
(1) There are reports that in two skin irritation tests with rabbits, irritation and superficial necrosis after application of this substance itself and mild irritation after application of a 10% soluti... | Provided | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | OCC#C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13B | J-GLOBAL | C#CCO | Train |
AU_HCIS:
chloroacetaldehyde
JP_CHRIP:
chloroacetaldehyde | AU_HCIS:
Acetaldehyde, chloro-
JP_CHRIP:
Chloroacetaldehyde
2-Chloro-1-ethanal
2-Chloroacetaldehyde
Monochloroacetaldehyde | 107-20-0 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=910
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2006e.html | JP_CHRIP:
In the rabbit test, application of a 55% aqueous solution of the substance to the abdominal skin caused severe corrosion (DFGMAK-Doc.12 (1999)). In another rabbit test, application of a 30% aqueous solution of the substance caused severe damage to skin (ACGIH (2001)). Based on these documents, the substance w... | null | AU_HCIS, JP_CHRIP | 2 | ClCC=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.060F | J-GLOBAL | O=CCCl | Train |
EU_REACH:
1,4-Dimethyl-1H-pyrazole | null | 1072-68-0 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18375/7/4/2/?documentUUID=7d543a91-d584-47a8-88a8-6e634e26088b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CN(N=C1)C | https://pubchem.ncbi.nlm.nih.gov/compound/136836 | PubChem | Cc1cnn(C)c1 | Train |
JP_CHRIP:
Chloromethyl methyl ether | JP_CHRIP:
Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade)
Chloromethoxymethane
Chloromethyl methyl ether (technical-grade)
CMME
Dimethylchloroether | 107-30-2 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2023e.html | JP_CHRIP:
Based on reports that application to the skin of animals resulted in erythema and necrosis (EHC 201 (1998)) and that contact with the substance can induce a risk of chemical injury or necrosis in humans (ACGIH (2001)), the substance was classified into Category 1. | null | JP_CHRIP | 1 | COCCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.063K | J-GLOBAL | COCCl | Train |
KR_NCIS:
Performic acid | null | 107-32-4 | 1 | KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | C(=O)OO | https://pubchem.ncbi.nlm.nih.gov/compound/66051 | PubChem | O=COO | Train |
EU_REACH:
2,2,4,4,6,6-hexamethyl-3,5-dioxa-2,4,6-trisilaheptane | null | 107-51-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16055/7/4/2/?documentUUID=d6ba6aac-bc83-4063-96af-881fe340ad45 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/24705 | PubChem | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | Train |
EU_REACH:
2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-3,5,7,9,11-pentaoxa-2,4,6,8,10,12-hexasilatridecane | null | 107-52-8 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20234/7/4/2/?documentUUID=55ac556e-5b08-4c40-90a7-603a32452e5b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/7875 | PubChem | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | Train |
AU_HCIS:
Phosphoric acid, dibutyl ester
JP_CHRIP:
Di-n-butyl phosphate | JP_CHRIP:
Di-n-butyl phosphate
Dibutyl acid o-phosphate
dibutyl phosphate
Phosphoric acid dibutyl ester
Phosphoric acid, dibutyl ester | 107-66-4 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6822
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2019e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified in Category 1. Besides, the category was changed due to the new data obtained.
[Evidence Data]
(1) In an in vitro skin corrosion test using an artificial human epidermis model (EST-1000) in compliance with OECD TG 431, following 3 minutes and... | null | AU_HCIS, JP_CHRIP | 2 | CCCCOP(=O)(O)OCCCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.769I | J-GLOBAL | CCCCOP(=O)(O)OCCCC | Train |
KR_NCIS:
Bis(2,4,4-trimethylpentyl)phosphinodithioic acid | null | 107667-02-7 | 1 | KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | CC(CC(C)(C)C)CP(=S)(CC(C)CC(C)(C)C)S | https://pubchem.ncbi.nlm.nih.gov/compound/163778 | PubChem | CC(CC(C)(C)C)CP(=S)(S)CC(C)CC(C)(C)C | Train |
NZ_CCID:
Isopentylamine | null | 107-85-7 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E42E4204-12D3-4C54-9191-3FC8D54CE4E2 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(C)CCN | https://pubchem.ncbi.nlm.nih.gov/compound/7894 | PubChem | CC(C)CCN | Train |
JP_CHRIP:
3-Methyl-2-butenal | JP_CHRIP:
3,3-Dimethylacrolein
3-Methylcrotonaldehyde | 107-86-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0036e.html | JP_CHRIP:
In a test by an occlusive application of undiluted this substance to the rabbit skin for 3 minutes, 1 hour, or 4 hours, edema, erythema, and necrosis were observed from 1 hour after the application, necrosis that occurred hardened with time and became leather-like, and this persisted until day 8, the end of t... | null | JP_CHRIP | 1 | CC(=CC=O)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.338F | J-GLOBAL | CC(C)=CC=O | Train |
EU_REACH:
butyric acid
JP_CHRIP:
butyric acid
NZ_CCID:
Butyric acid | JP_CHRIP:
1-Propanecarboxylic acid
Butanic acid
Ethylacetic acid
n-Butanoic acid | 107-92-6 | 1 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13507/7/4/2/?documentUUID=93aea964-09a1-4fae-ad50-7b7cbac551aa
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0159e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B2AFB... | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
In List 1 data (PATTY (5th, 2001)), the substance is documented to be a severe irritant in rabbit tests, and in List 2 data (IUCLID (2000)), it is reported to be corrosive in rabbit tests (OECD Guidelines 404). In addition, it is rated as R34 in the EU classifi... | Provided | EU_REACH, JP_CHRIP, NZ_CCID | 3 | CCCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.068A | J-GLOBAL | CCCC(=O)O | Train |
JP_CHRIP:
3-Chloropropionic acid
NZ_CCID:
3-Chloropropionic acid | JP_CHRIP:
3-Chloropropionic acid
Propanoic acid, 3-chloro- | 107-94-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2037e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7EDFCF0-F122-4BE5-BAA3-19B92CC7E6C6 | JP_CHRIP:
[Rationale for the Classification]
It was classified in Category 1 from (1), (2).
[Evidence Data]
(1) The pH of this substance (200 g/L) was 0.9 (GESTIS (Access on May 2020)).
(2) This substance and its aqueous solutions were strong irritative/corrosive to the eye and skin (GESTIS (Access on May 2020)).
NZ_... | null | JP_CHRIP, NZ_CCID | 2 | OC(=O)CCCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.069J | J-GLOBAL | O=C(O)CCCl | Train |
EU_REACH:
β-alanine | null | 107-95-9 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2084/7/4/2/?documentUUID=d7e37368-f9ac-430c-90cc-889f6f27ce53 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CN)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/239 | PubChem | NCCC(=O)O | Train |
JP_CHRIP:
beta-Mercaptopropionic acid
NZ_CCID:
3-Mercaptopropionic acid | null | 107-96-0 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0161e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8C417E85-018E-4EAB-9F06-9D09571A24E0 | JP_CHRIP:
The substance was classified as Category 1 based on the documented case of "corrosive" (SIDS (2009)) resulted from the rabbit test in which necrosis and burns accompanied by erythema and edema were observed within 15 minutes of occlusive application of the test substance.
NZ_CCID:
Skin Irritation
R PHRASE: R... | null | JP_CHRIP, NZ_CCID | 2 | OC(=O)CCS | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.166G | J-GLOBAL | O=C(O)CCS | Train |
NZ_CCID:
Chlorodiphenylphosphine | null | 1079-66-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7C22DC71-BBFE-4D3A-B969-4C56939405CC | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC=C(C=C1)P(C2=CC=CC=C2)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66180 | PubChem | ClP(c1ccccc1)c1ccccc1 | Train |
NZ_CCID:
1,2-Ethanediamine, N,N-dimethyl- | NZ_CCID:
N,N-dimethylethylenediamine | 108-00-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39607F72-2040-486E-B82E-2BCA0E277514 | NZ_CCID:
Skin Irritation
UN CLASS: PG II | null | NZ_CCID | 1 | CN(C)CCN | https://pubchem.ncbi.nlm.nih.gov/compound/66053 | PubChem | CN(C)CCN | Train |
AU_HCIS:
Ethanol, 2-(dimethylamino)-
JP_CHRIP:
2-dimethylaminoethanol; N,N-dimethylethanolamine
NZ_CCID:
Dimethylaminoethanol
US_HSDB:
2-DIMETHYLAMINOETHANOL | AU_HCIS:
2-dimethylaminoethanol
N,N-dimethylethanolamine
JP_CHRIP:
2-dimethylaminoethanol
Dimethylethanolamine
N,N-Dimethyl-2-hydroxyethylamine
N,N-dimethylethanolamine
NZ_CCID:
(2-Hydroxyethyl)dimethylamine, 2-(Dimethylamino) ethanol, 2-(Dimethylamino)-1-ethanol, 2-(Dimethylamino)ethanol, 2-(N,N-Dimethylamino)ethano... | 108-01-0 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1879
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0034e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11B13060-5626-4367-8D9D-F5F7DAA55F78
US_HSDB: https://p... | JP_CHRIP:
Since GLP tests using rabbits concluded that the substance was corrosive (IUCLID, 2000), it was classified into Category 1.
NZ_CCID:
Skin Irritation
R-PHRASE: R 34. [N-CLASS]
Eye Irritation
R-PHRASE: R 34. [N-CLASS] | null | AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB | 4 | CN(C)CCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.068G | J-GLOBAL | CN(C)CCO | Train |
EU_REACH:
4-methylpentan-2-one
JP_CHRIP:
Methyl isobutyl ketone | JP_CHRIP:
4-Methyl-2-pentanone
4-Methyl-2-pentanone; Methyl isobutyl ketone
4-methylpentan-2-one
Hexone
Isopropylacetone
methylisobutyl ketone
methylisobutyl ketone(2-methyl-4-pentanone)
MIBK | 108-10-1 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14866/7/4/2/?documentUUID=61c2bbba-4873-420b-b530-05db459b7160
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0099e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
There is a report that in a skin irritation test with rabbits, as a result of an occlusive application with this substance for 10 hours, erythema was persistent until after 24 hours (SIDS (2011), EHC117 (1990), NTP TR 538 (2007)). In addition, there is a report... | Provided | EU_REACH, JP_CHRIP | 2 | CC(C)CC(=O)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.861D | J-GLOBAL | CC(=O)CC(C)C | Train |
NZ_CCID:
Isopentanoyl chloride | NZ_CCID:
isovaleryl chloride | 108-12-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/867E4D5E-34C4-417A-A200-391425F8F73A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(C)CC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66054 | PubChem | CC(C)CC(=O)Cl | Train |
NZ_CCID:
1-(Dimethylamino)-2-propanol | null | 108-16-7 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/741C2CB9-124E-45D9-BCFF-B9F7FA9CCF1B | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(CN(C)C)O | https://pubchem.ncbi.nlm.nih.gov/compound/37511 | PubChem | CC(O)CN(C)C | Train |
EU_REACH:
bis(propan-2-yl)amine
JP_CHRIP:
Diisopropylamine
NZ_CCID:
2-Propanamine, N-(1-methylethyl)- | JP_CHRIP:
Diisopropylamine
DIPA
N-(1-methylethyl)-2-propanamine
NZ_CCID:
Diisopropylamine, n-(1-Methylethyl)-2-propanamine | 108-18-9 | 1 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13145/7/4/2/?documentUUID=a6ad48e3-cf29-472e-b939-e9846a21f2ca
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2118e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0E0E... | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
In a skin irritation test with rabbits (OECD TG 404 compliant), clear evidence of necrosis (discoloration to reddish brown and greenish brown at the application site) was observed within 24 hours after the 3-minute application of this substance. This was follow... | Provided | EU_REACH, JP_CHRIP, NZ_CCID | 3 | CC(C)NC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.496F | J-GLOBAL | CC(C)NC(C)C | Train |
JP_CHRIP:
Isopropyl ether | JP_CHRIP:
2,2'-Oxybispropane
2-Isopropoxypropane
diisopropyl ether
Isopropyl ether | 108-20-3 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2020e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified as "Not classified."
[Evidence Data]
(1) In a ski irritation test in which 0.5 mL of this substance was applied semiocclusively to the skin of rabbits for 4 hours in accordance with OECD TG 404, the mean scores at 24/48/72 hours for erythema ... | Provided | JP_CHRIP | 1 | CC(C)OC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.069E | J-GLOBAL | CC(C)OC(C)C | Train |
EU_REACH:
isopropenyl acetate | null | 108-22-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17298/7/4/2/?documentUUID=37ceb158-2d81-44c8-ab37-dc1cdb5a3eb5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=C)OC(=O)C | https://pubchem.ncbi.nlm.nih.gov/compound/7916 | PubChem | C=C(C)OC(C)=O | Train |
JP_CHRIP:
Isopropyl chloroformate | JP_CHRIP:
Carbonochloridic acid 1-methylethyl ester
Chloroformic acid, isopropyl ester
isopropyl 1-chloromethanoate
Isopropyl chlorocarbonate
isopropyl chloroformate
Isopropyl chloromethanate | 108-23-6 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0067e.html | JP_CHRIP:
Based on a report that direct dropwise application to the skin causes deep necrosis and eschar formation in a guinea pig test (PATTY (5th, 2001)) and a report of "irritating and corrosive to the skin" (HSDB (2003)), the substance was classified into Category 1. | null | JP_CHRIP | 1 | CC(C)OC(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.720E | J-GLOBAL | CC(C)OC(=O)Cl | Train |
JP_CHRIP:
Acetic anhydride
NZ_CCID:
Acetic anhydride
US_HSDB:
Acetic anhydride | JP_CHRIP:
Acetic acid, anhydride
Acetic oxide
Acetyl oxide
Ethanoic anhydride
NZ_CCID:
Acetanhydride, Acetic acid, anhydride, Acetic oxide, Acetyl acetate, Acetyl anhydride, Acetyl ether, Acetyl oxide, Ethanoic anhydride | 108-24-7 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2021e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54C46A7E-73BC-4DB8-A03B-0BF27040E37C
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/233 | JP_CHRIP:
[Rationale for the Classification]
Based on (1)-(4), it was classified in Category 1.
[Evidence Data]
(1) This substance is a severe irritant to the eyes, mucous membranes and skin, and severe burns and vesiculation of the skin were reported from liquid splashes (ACGIH (7th, 2001)).
(2) In a skin irritation ... | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CC(=O)OC(=O)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.417A | J-GLOBAL | CC(=O)OC(C)=O | Train |
AU_HCIS:
maleic anhydride
JP_CHRIP:
Maleic anhydride
NZ_CCID:
Maleic anhydride
US_HSDB:
MALEIC ANHYDRIDE | AU_HCIS:
2,5-Furandione
JP_CHRIP:
2,5-Furandione
cis-Butenedioic anhydride
Dihydro-2,5-dioxofuran
Maleic acid anhydride
Maleic anhydride
NZ_CCID:
2,5-Furandione, Dihydro-2,5-dioxofuran, Maleic acid anhydride, Toxilic anhydride, cis-Butenedioic anhydride | 108-31-6 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2795
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2026e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FAACCC4-8E62-4C8D-A7E6-A40199911812
US_HSDB: https://p... | JP_CHRIP:
It is described in DFGOT vol. 4 (1992) that the application of the powder moistened with water caused necrosis in a skin irritation test with rabbits, although it is not a result of a 4-hour application. And it is described in SIDS (2007) that there was severe irritation in a skin irritation test with rabbits... | null | AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB | 4 | O=C1OC(=O)C=C1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.419H | J-GLOBAL | O=C1C=CC(=O)O1 | Train |
JP_CHRIP:
propylene carbonate | JP_CHRIP:
2-oxo-4-methyl-1,3-dioxolane
propylene carbonate | 108-32-7 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0160e.html | JP_CHRIP:
The classification is based on descriptions that the substance was found to be a slight irritant in rabbit tests (PATTY (5th, 2001)) and it caused no irritation in other rabbit tests (OECD Guidelines 404) (IUCLID (2000)). | Provided | JP_CHRIP | 1 | CC1COC(=O)O1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.073C | J-GLOBAL | CC1COC(=O)O1 | Train |
AU_HCIS:
m-cresol [1]
JP_CHRIP:
m-Cresol
KR_NCIS:
m-Cresol
NZ_CCID:
3-Cresol
US_HSDB:
m-CRESOL | AU_HCIS:
o-cresol [2]
p-cresol [3]
mix-cresol [4]
Phenol, 3-methyl-
m-cresol
o-cresol
p-cresol
JP_CHRIP:
1-Hydroxy-3-methylbenzene
3-Cresol
3-Hydroxytoluene
3-Methylphenol
cresol
m-cresol
m-Cresol; 3-Methylphenol
Phenol, 3-methyl-
KR_NCIS:
1-Hydroxy-3-methylbenzene; 1-Hydroxy-3-methylbenzol; 1-Oxy-3-methylbenzol; 3... | 108-39-4 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1066
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2137e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-in... | JP_CHRIP:
There is a report that when 0.5 mL of the undiluted liquid of this substance was applied to the skin of rabbits, severe erythema and edema occurred within 24 hours and this did not disappear within 72 hours (SIDS (2005)). In other tests with rabbits, there is a report that irreversible tissue destruction was ... | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 5 | Cc1cccc(O)c1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.186J | J-GLOBAL | Cc1cccc(O)c1 | Train |
EU_REACH:
tert-butyl (2S)-2-[5-(4'-{2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate | null | 1085706-46-2 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6021/7/4/2/?documentUUID=629fb0da-1cd8-4863-a858-26f103bc9944 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)(C)OC(=O)N1CCC[C@H]1C2=CC(=NN2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)OC(C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/59345130 | PubChem | CC(C)(C)OC(=O)N1CCC[C@H]1c1cc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)OC(C)(C)C)[nH]4)cc3)cc2)n[nH]1 | Train |
EU_REACH:
2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane
JP_CHRIP:
2,4,6,8-Tetramethyl-1,3,5,7-tetraoxacyclooctane | JP_CHRIP:
2,4,6,8-tetramethyl-1,3,5,7-tetraoxacyclooctane (synonym:metaldehyde)
metaldehyde | 108-62-3 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24890/7/4/2/?documentUUID=76e6ec4f-e828-4812-a5d5-db97444d7c48
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0185e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
Based on a report of "not irritant" in a rabbit test (EPA RED (2006), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2009)). | Provided | EU_REACH, JP_CHRIP | 2 | CC1OC(C)OC(C)OC(C)O1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.423F | J-GLOBAL | CC1OC(C)OC(C)OC(C)O1 | Train |
JP_CHRIP:
3,5-xylenol; 3,5-Dimethylphenol
KR_NCIS:
3,5-Dimethylphenol
NZ_CCID:
Phenol, 3,5-dimethyl- | JP_CHRIP:
3,5-Xylenol
Phenol, 3,5-dimethyl-
KR_NCIS:
1,3,5-Xylenol; 1-Hydroxy-3,5-dimethylbenzene; 3,5-Xylenol; Phenol, 3,5-dimethyl-; XYLENOL
NZ_CCID:
3,5-XYLENOL | 108-68-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2028e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D1BCFDA-2209-4D23-A4E5-DA83B7A37971 | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1.
[Evidence Data]
(1) Moderate burns to the skin were reported in rabbits after administration to the skin (concentration not specified) (NICNAS IMAP (Access on August 2019)).
(2) It was classified in "Skin Corr. 1B (H314... | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | Cc1cc(C)cc(O)c1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.425B | J-GLOBAL | Cc1cc(C)cc(O)c1 | Train |
JP_CHRIP:
Melamine | JP_CHRIP:
1,3,5-Triazine-2,4,6-triamine
2,4,6-Triamino-1,3,5-triazine
2,4,6-triamino-1,3,5-triazine (melamine)
Cyanurotriamide | 108-78-1 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0004e.html | JP_CHRIP:
[Rationale for the Classification]
It was classified as "Not classified" from (1) - (3).
[Evidence Data]
(1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)).
(2) In a patch test in humans, no skin irritation or... | Provided | JP_CHRIP | 1 | Nc1nc(N)nc(N)n1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.428G | J-GLOBAL | Nc1nc(N)nc(N)n1 | Train |
JP_CHRIP:
2,6-Dimethylheptan-4-ol | null | 108-82-7 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0037e.html | JP_CHRIP:
The substance was classified as "Not classified" based on the rabbit test (OECD TG404) in which erythema and edema were not observed at 24, 48 and 72 hours after patch removal, and the PII was 0 (ECETOC TR66 (1995)). | Provided | JP_CHRIP | 1 | CC(C)CC(O)CC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J58.121F | J-GLOBAL | CC(C)CC(O)CC(C)C | Train |
JP_CHRIP:
Diisobutyl ketone | JP_CHRIP:
2,6-Dimethyl-4-heptanone
2,6-dimethylheptan-4-one
Isovalerone | 108-83-8 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0095e.html | JP_CHRIP:
As for skin irritation tests (OECD TG404) with rabbits, both results of slight irritation and no irritation are reported as a result of a semi-occlusive application of this substance for 4 hours (SIDS (2004)). In addition, there is a report that in other skin irritation test with rabbits, as a result of a sem... | Provided | JP_CHRIP | 1 | CC(C)CC(=O)CC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.081D | J-GLOBAL | CC(C)CC(=O)CC(C)C | Train |
AU_HCIS:
cyclohexylamine
JP_CHRIP:
Cyclohexylamine
KR_NCIS:
Cyclohexylamine
NZ_CCID:
Cyclohexanamine | AU_HCIS:
Cyclohexanamine
aminocyclohexane
aminohexahydrobenzene
hexahydroaniline
hexahydrobenzenamine
JP_CHRIP:
Aminocyclohexane
Aminohexahydrobenzene
Cyclohexanamine
Cyclohexylamine
Hexahydroaniline
KR_NCIS:
aminocyclohexane; hexahydroaniline
NZ_CCID:
1-Aminocyclohexane, 1-Cyclohexylamine, Aminocyclohexane, Aminohe... | 108-91-8 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1117
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2009e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-in... | JP_CHRIP:
Open application to the rabbit skin resulted in a damage level of 7 on a scale of 1 to 10 within 24 hours, necrosis was seen (DFGMAK-Doc. 22 (2006)), and it is reported that this substance was found to be corrosive after 4-hour or 24-hour semi-occlusive application of 0.5 mL to the rabbit skin (DFGMAK-Doc. 22... | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID | 4 | NC1CCCCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.870C | J-GLOBAL | NC1CCCCC1 | Train |
JP_CHRIP:
Phenol
KR_NCIS:
Phenol
NZ_CCID:
Phenol | JP_CHRIP:
Benzenol
Carbolic acid
Hydroxybenzene
Phenic acid
phenol, pure
KR_NCIS:
Hydroxybenzene
NZ_CCID:
(Mono)hydroxybenzene, Benzenol, Carbolic acid, Oxybenzene, Phenic acid, Phenyl alcohol, Phenyl hydrate, Phenyl hydroxide, Phenylic acid, Phenylic alcohol | 108-95-2 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2007.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3817198F-CE0B-4133-87EE-5EE65B03E140 | JP_CHRIP:
【分類根拠】
（１）～（５）より区分1とした。
【根拠データ】
（１）本物質を含有する皮膚局所薬剤投与で刺激性皮膚炎の発生がみられ、皮膚への局所ばく露では、その部位に漂白作用又は紅疹が発生し、腐食や壊死に到る場合がある（CERI 有害性評価書 (2008)、MOE 初期評価 (2002)）。
（２）本物質はヒトが経口及び経皮ばく露すると、皮膚、眼及び粘膜に対して強い刺激性を示す（CERI 有害性評価書 (2008)）。
（３）本物質はウサギの皮膚に腐食性を示した（EPA Pesticides RED (2009)）。
（４）ウサギ、ラット、マウス、ブタの眼又は皮膚に本物質を適用した結果、発赤、炎症、変色、発疹、... | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | Oc1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.873H | J-GLOBAL | Oc1ccccc1 | Train |
NZ_CCID:
1-Methylpiperazine | null | 109-01-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6ED348DF-57B5-421A-9526-51D40A328D78 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data | null | NZ_CCID | 1 | CN1CCNCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/53167 | PubChem | CN1CCNCC1 | Train |
NZ_CCID:
Morpholine, 4-methyl- | NZ_CCID:
4-methylmorpholine | 109-02-4 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B9007-ED91-4267-B18A-5FF4BCA0B94E | NZ_CCID:
Skin Irritation
UN CLASS: Sub Risk 8; PG II
R PHRASE: R 34 [MSDS, ABCR Gmbh and Co.]
[Chemfinder]
Eye Irritation
R-PHRASE: R 34. MSDS, ABCR Gmbh and Co.
[Chemfinder] | null | NZ_CCID | 1 | CN1CCOCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/7972 | PubChem | CN1CCOCC1 | Train |
JP_CHRIP:
2-Methylpyridine (2-Picoline) | JP_CHRIP:
2-methylpyridine
2-Picoline
alpha-Picoline
o-Picoline
Pyridine, 2-methyl- | 109-06-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2021e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained.
[Evidence Data]
(1) There is a report that in a skin irritation test (U.S. 49 CFR 173.240) with rabbits (n=6), after a 4-hour occlusive application of this su... | null | JP_CHRIP | 1 | Cc1ccccn1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.087C | J-GLOBAL | Cc1ccccn1 | Train |
EU_REACH:
2-(chloromethyl)-4-methylquinazoline | null | 109113-72-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5361/7/4/2/?documentUUID=da6ee861-4d6c-48d7-8dbb-ae69aff4d045 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=NC(=NC2=CC=CC=C12)CCl | https://pubchem.ncbi.nlm.nih.gov/compound/241518 | PubChem | Cc1nc(CCl)nc2ccccc12 | Train |
EU_REACH:
tert-butyl 2-methylpropaneperoxoate | null | 109-13-7 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11987/7/4/2/?documentUUID=3211c910-debc-4194-acf9-fb39a6a268b8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)C(=O)OOC(C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/61023 | PubChem | CC(C)C(=O)OOC(C)(C)C | Train |
EU_REACH:
docosyl 4-hydroxybenzoate | null | 109236-76-2 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17137/7/4/2/?documentUUID=80544fc4-ffef-4ee8-859c-e3003de26978 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCCCCCCCCCCCCCCCOC(=O)C1=CC=C(C=C1)O | https://pubchem.ncbi.nlm.nih.gov/compound/13923401 | PubChem | CCCCCCCCCCCCCCCCCCCCCCOC(=O)c1ccc(O)cc1 | Train |
AU_HCIS:
9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (Z)- | null | 109-28-4 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6760 | null | null | AU_HCIS | 1 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/6436063 | PubChem | CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C | Train |
EU_REACH:
oxacycloheptadecan-2-one | null | 109-29-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24078/7/4/2/?documentUUID=6c9e667b-e071-43c6-9639-68604402dd91 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CCCCCCCC(=O)OCCCCCCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/7984 | PubChem | O=C1CCCCCCCCCCCCCCCO1 | Train |
EU_REACH:
1,3-dibutyl-2-thiourea | null | 109-46-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26084/7/4/2/?documentUUID=06e11ce9-90d4-4319-9d3e-083179e35202 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCNC(=S)NCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/2723622 | PubChem | CCCCNC(=S)NCCCC | Train |
JP_CHRIP:
valeric acid
NZ_CCID:
Pentanoic acid | JP_CHRIP:
1-Butanecarboxylic acid
n-Pentanoic acid
Propylacetic acid
Valeric acid
NZ_CCID:
valeric acid | 109-52-4 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0092e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF30F573-B567-4F11-8DF4-D2F4F6318CCD | JP_CHRIP:
Since there is a description that, valeric acid is a strong skin irritant in undiluted form (PATTY (5th, 2001)), and valeric acid is rated iC; R34 by EU (EU-AnnexI (accessed August 2008)), the substance was classified into Category 1. As relevant information, it is reported that using mixed isomers of valeric... | null | JP_CHRIP, NZ_CCID | 2 | CCCCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.504K | J-GLOBAL | CCCCC(=O)O | Train |
AU_HCIS:
3-aminopropyldimethylamine
JP_CHRIP:
3-aminopropyldimethylamine; N,N-dimethyl-1,3-diaminopropane
NZ_CCID:
3-Dimethylaminopropylamine | AU_HCIS:
N,N-dimethyl-1,3-diaminopropane
1,3-Propanediamine, N,N-dimethyl-
JP_CHRIP:
1,3-Propanediamine, N,N-dimethyl-
1-Amino-3-dimethylaminopropane
3-aminopropyldimethylamine
N,N,-Dimethyl-1,3-propanediamine
N,N-Dimethyl-1,3-diaminopropane
NZ_CCID:
N,N-Dimethyltrimethylenediamine | 109-55-7 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=219
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0037e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6DBCCA85-778B-4CE8-9459-D51F291EE5FA | JP_CHRIP:
There are several reports characterizing the substance as strongly irritating to corrosive in rabbit tests (IUCLID (2000), BUA report No. 197 (1996)). In addition, the substance was documented to cause necrosis as its dermal symptom (BUA report No. 197 (1996)). As such, the substance was classified into Categ... | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | CN(C)CCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.732F | J-GLOBAL | CN(C)CCCN | Train |
JP_CHRIP:
Propyl chloroformate
KR_NCIS:
n-Propyl chloroformate | JP_CHRIP:
Carbonochloridic acid, propyl ester
Formic acid, chloro-, propyl ester
Propyl chlorocarbonate
KR_NCIS:
Carbonochloridic acid, propyl ester; CHLOROFORMATE, PROPYL; Formic acid, chloro-, propyl ester; n-Propyl chloroformate; Propyl chlorocarbonate; Propyl chloroformate | 109-61-5 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2023e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified in Category 1B.
[Evidence Data]
(1) In a skin corrosion test in which 0.5 mL of this substance was applied to two rabbits, it was corrosive, and persistent erythema, edema and necrosis were observed after 15-minute and 20-hour exposure (SIDS ... | null | JP_CHRIP, KR_NCIS | 2 | CCCOC(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.719A | J-GLOBAL | CCCOC(=O)Cl | Train |
JP_CHRIP:
n-Pentane | JP_CHRIP:
Amyl hydride
n-Pentane | 109-66-0 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2096e.html | JP_CHRIP:
Based on a primary irritation index of 0.67 in a skin irritation test with rabbits (OECD TG 404, GLP-compliant), it was judged not to be irritating (SIDS (2010), EU-RAR (2003)). In addition, it is described that this substance is not irritating as a result of 24-hour semi-occlusive application to humans (GLP-... | Provided | JP_CHRIP | 1 | CCCCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J15I | J-GLOBAL | CCCCC | Train |
JP_CHRIP:
n-Butylamine
KR_NCIS:
n-Butylamine
NZ_CCID:
1-Butanamine | JP_CHRIP:
1-Aminobutane
Monobutylamine
n-Butylamine
KR_NCIS:
1-Butanamine; 1-aminobutane; Monobutylamine;Butan-1-amine
NZ_CCID:
1-Aminobutane, Mono-n-butylamine, Monobutylamine, Norvalamine, n-Butylamine | 109-73-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2119e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/04BD6D13-E553-4012-8A6A-1E85A90D7E82 | JP_CHRIP:
There is a description that in a skin irritation test with guinea pigs, necrosis occurred after application (OEL Documentations (Japan Society For Occupational Health, 1994)). There is a description that in a skin irritation test (equivalent to OECD TG 404) with rabbits, in exposure time of 1 minute, immediat... | Provided | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | CCCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.436H | J-GLOBAL | CCCCN | Train |
NZ_CCID:
1,3-Diaminopropane | NZ_CCID:
1,3-propylenediamine | 109-76-2 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FA76FE5-2F11-461E-AB95-6CB542DBF178 | NZ_CCID:
Skin Irritation
UN #2734 UN CLASS: 8 PG II
Eye Irritation
R PHRASE: R 35 [Company Data]
UN #2734 UN CLASS: 8 PG II | null | NZ_CCID | 1 | C(CN)CN | https://pubchem.ncbi.nlm.nih.gov/compound/428 | PubChem | NCCCN | Train |
JP_CHRIP:
2-methylaminoethanol
NZ_CCID:
2-(Methylamino) ethanol
US_HSDB:
2-Methylaminoethanol | JP_CHRIP:
(2-Hydroxyethyl)methylamine
2-(methylamino)ethanol
2-methylaminoethanol
Methylethylolamine
Monomethylethanolamine
NZ_CCID:
2-methylaminoethanol | 109-83-1 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0093e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C06F2FAD-F992-4DF1-992C-0526C97B09E2
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1128 | JP_CHRIP:
The classification is based on the results of "being corrosive" after application to skin of rabbits for 1 - 4 hours (IUCLID (2000)). As relevant notes, its pH is 13.4 (100 mL/L) (IUCLID (2000)), and it is rated C;R34 in EU classification (EU-Annex 1 (accessed August 2008)).
NZ_CCID:
Skin Irritation
R PHRASE... | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CNCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.187H | J-GLOBAL | CNCCO | Train |
NZ_CCID:
2-Methoxyethylamine | null | 109-85-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C11A983-26C0-468A-B6A0-04611D6017CE | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | COCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8018 | PubChem | COCCN | Train |
EU_REACH:
Isooctadecanoic acid, 1,1'-(2,2-dimethyl-1,3-propanediyl) ester | null | 109884-54-0 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17513/7/4/2/?documentUUID=5003d932-d1e9-490c-96ee-8adab9b79cf7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/10282874 | PubChem | CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C | Train |
JP_CHRIP:
Diethylamine
NZ_CCID:
Ethanamine, N-ethyl-
US_HSDB:
DIETHYLAMINE | JP_CHRIP:
Diethamine
N,N-Diethylamine
N-Ethylethanamine
NZ_CCID:
Diethylamine, N,N-Diethylamine, n-Ethylethanamine | 109-89-7 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2042e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5819CBE2-8F54-4733-8F2D-4C4262A0407E
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/524 | JP_CHRIP:
There are multiple reports that it was corrosive in tests with rabbits (ACGIH (7th, 2013), IUCLID (2000)). Additionally, there is a description that this substance was severely irritating, and the skin of the contact site was damaged (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). F... | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CCNCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J807I | J-GLOBAL | CCNCC | Train |
JP_CHRIP:
Ethyl vinyl ether | JP_CHRIP:
ethyl vinyl ether | 109-92-2 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0048e.html | JP_CHRIP:
Based on reports of grade 1 (maximum grade 10) irritation after open application to the skin of rabbits (PATTY (5th, 2001)), and not irritating in another rabbit test (OECD TG404), the substance was classified as "Not classified". | Provided | JP_CHRIP | 1 | CCOC=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.440F | J-GLOBAL | C=COCC | Train |
EU_REACH:
2-({3-[bis(cyanomethyl)amino]propyl}(cyanomethyl)amino)acetonitrile | null | 110057-45-9 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4332/7/4/2/?documentUUID=8313cf05-f1e8-4098-8ad7-0ce8f2f0a05f | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CN(CC#N)CC#N)CN(CC#N)CC#N | https://pubchem.ncbi.nlm.nih.gov/compound/314171 | PubChem | N#CCN(CC#N)CCCN(CC#N)CC#N | Train |
EU_REACH:
succinic acid | null | 110-15-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15265/7/4/2/?documentUUID=42f74ea6-278b-4aac-bcbc-20d60bbcf2da | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CC(=O)O)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/1110 | PubChem | O=C(O)CCC(=O)O | Train |
JP_CHRIP:
N,N,N',N'-tetramethylethylenediamine
NZ_CCID:
1,2-Ethanediamine, N,N,N',N'-tetramethyl- | JP_CHRIP:
N,N,N',N'-Tetramethyl-1,2-ethanediamine
NZ_CCID:
Propamine D, Temed, Tetrameen, Tetramethyl ethylene diamine, Tetramethyldiaminoethane | 110-18-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0167e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/22193BD3-92A5-4F59-817B-BD1499249582 | JP_CHRIP:
In skin irritation tests using rabbits (HSDB (2002)), 1-hour and 4-hour applications resulted in full-thickness necrosis or ulceration and ecchymoses; and the necrosis persisted for 14 days. Based on this information, the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESU... | null | JP_CHRIP, NZ_CCID | 2 | CN(C)CCN(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.745K | J-GLOBAL | CN(C)CCN(C)C | Train |
ChemSkin:
Isopropyl myristate
EU_REACH:
isopropyl myristate | null | 110-27-0 | 0 | ChemSkin: https://doi.org/10.3390/toxics9110314
EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16077/7/4/2/?documentUUID=ced703af-f120-4c1f-bea9-59e0b6a33326 | ChemSkin:
Experimental study (OECD TG 404)
EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | ChemSkin, EU_REACH | 2 | CCCCCCCCCCCCCC(=O)OC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/8042 | PubChem | CCCCCCCCCCCCCC(=O)OC(C)C | Train |
EU_REACH:
2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid | null | 1103234-56-5 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8013/7/4/2/?documentUUID=8cf76091-2c73-4919-b6a9-59a7249d0760 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)O)F | https://pubchem.ncbi.nlm.nih.gov/compound/46192923 | PubChem | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F | Train |
EU_REACH:
2-methyl-4,6-bis[(octylsulfanyl)methyl]phenol | null | 110553-27-0 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13350/7/4/2/?documentUUID=c5664c74-61e4-4751-a365-e08a272f853b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCSCC1=CC(=C(C(=C1)C)O)CSCCCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/113646 | PubChem | CCCCCCCCSCc1cc(C)c(O)c(CSCCCCCCCC)c1 | Train |
NZ_CCID:
Amylamine | NZ_CCID:
N-Pentylamine | 110-58-7 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CCE3EABA-1E70-4D06-A6C1-73A681F66700 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8060 | PubChem | CCCCCN | Train |
NZ_CCID:
1,4-Diaminobutane | NZ_CCID:
putrescine | 110-60-1 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FB495BD-EFEE-4F4A-82C5-8BDAD63297AB | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCN)CN | https://pubchem.ncbi.nlm.nih.gov/compound/1045 | PubChem | NCCCCN | Train |
JP_CHRIP:
2-Butyne-1,4-diol
KR_NCIS:
2-Butyne-1,4-diol
NZ_CCID:
2-Butyne-1,4-diol | JP_CHRIP:
1,4-Butynediol
1,4-Dihydroxy-2-butyne
2-Butynediol
But-2-yne-1,4-diol
KR_NCIS:
Butynediol; But-2-yne-1,4-diol
NZ_CCID:
2-BUTYNEDIOL, BIS(HYDROXYMETHYL)ACETYLENE, BUTYNEDIOL | 110-65-6 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0026e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3754F63-18D5-46D6-8120-81E735B4679C | JP_CHRIP:
In the rabbit test (OECD TG 404) treated 6 animals with 0.5 g for 4 hours, severe erythema and severe edema within 24 hours, and necrosis within 6 days were noted in all animals. Based on the information, the substance was classified as Category 1. The substance was classified as "R34" in the EU classificatio... | Provided | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | OCC#CCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.098I | J-GLOBAL | OCC#CCO | Train |
AU_HCIS:
Phenol, isononyl-
KR_NCIS:
Isononylphenol | null | 11066-49-2 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5792
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | AU_HCIS, KR_NCIS | 2 | CC(C)CCCCCCC1=CC=CC=C1O | https://pubchem.ncbi.nlm.nih.gov/compound/119757 | PubChem | CC(C)CCCCCCc1ccccc1O | Train |
NZ_CCID:
Butylmethylamine | NZ_CCID:
N-Methylbutylamine, N-butylmethylamine | 110-68-9 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C445C8AD-F04B-4CB8-948C-F49B51562D96 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCNC | https://pubchem.ncbi.nlm.nih.gov/compound/8068 | PubChem | CCCCNC | Train |
NZ_CCID:
2-(Ethylamino) ethanol | null | 110-73-6 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4C3AAF5-BE47-48D2-90B9-62EEFF41DECA | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCNCCO | https://pubchem.ncbi.nlm.nih.gov/compound/8072 | PubChem | CCNCCO | Train |
AU_HCIS:
piperazine
JP_CHRIP:
Piperazine
NZ_CCID:
Piperazine | AU_HCIS:
[liquid]
JP_CHRIP:
1,4-Diazacyclohexane
1,4-Diethylenediamine
Antiren
Diethyleneimine
Hexahydropirazine | 110-85-0 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3552
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0015e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7CAEF84F-55E5-4F70-833F-89CA4277EB87 | JP_CHRIP:
There is a report that in a skin irritation test (OECD TG404) with rabbits, as a result of a semi-occlusive application of this substance (50% aqueous solution) for 4 hours, severe erythema and necrosis were observed (EU-RAR (2005)). In addition, there is a report that in another skin irritation test with rat... | Provided | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | C1CNCCN1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.981J | J-GLOBAL | C1CNCCN1 | Train |
AU_HCIS:
piperidine
JP_CHRIP:
piperidine
NZ_CCID:
Piperidine | JP_CHRIP:
Azacyclohexane
Hexahydropyridine
Pentamethyleneimine
NZ_CCID:
Azacyclohexane, Cyclopentimine, Cypentil, Hexahydropyridine, Hexazane, Pentamethyleneimine, Pentamethylenimine, Perhydropyridine, Pyridine, hexahydro- | 110-89-4 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3555
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0169e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56281F0D-7408-4FB6-A95C-3022A12B8D5E | JP_CHRIP:
In the study using 6 rabbits, necrosis was observed in all test animals (PATTY (5th, 2001)). In other animal tests, the substance was reported to have a corrosive effect (HSDB (2008)). Furthermore, in human accident cases, severe epithelial damage and chemical burns were reported with the substance in contact... | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | C1CCNCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.884C | J-GLOBAL | C1CCNCC1 | Train |
AU_HCIS:
morpholine
EU_REACH:
morpholine
JP_CHRIP:
Morpholine
NZ_CCID:
Morpholine | JP_CHRIP:
Diethylene oximide
Tetrahydro-1,4-oxazine
tetrahydro-1,4-oxazine [synonym:morpholine]
NZ_CCID:
1-Oxa-4-azacyclohexane, 2H-1,4-Oxazine, tetrahydro-, 4H-1,4-Oxazine, tetrahydro-, Diethylene imidoxide, Diethylene oximide, Diethyleneimide oxide, Diethylenimide oxide, Drewamine, Tetrahydro-1,4-oxazine, Tetrahydro... | 110-91-8 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3091
EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13364/7/4/2/?documentUUID=b5fbf61e-b34d-454d-90ce-c03f3e99c9d0
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2042e.html
NZ_CCID: https://www.epa.... | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
Based on the description that this substance is corrosive to the human skin (SIDS (2015)), and multiple test reports that necrosis occurred due to the application of this substance in skin irritation tests with rabbits (EHC 179 (1996), IARC 47 (1989), ACGIH (7t... | Provided | AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID | 4 | C1COCCN1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.453H | J-GLOBAL | C1COCCN1 | Train |
NZ_CCID:
1-Propanamine, 2-methyl-N-(2-methylpropyl)- | NZ_CCID:
Diisobutylamine | 110-96-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0FADC70-DC8C-43B3-B549-0A727A41A55F | NZ_CCID:
Skin Irritation
REMARK: UN 2361 Class 3.0;Sub Risk 8; PG III
Eye Irritation
SPECIES:
RESULT: Irritating
REFERENCE SOURCE: Review by Thomas (1990) Ethyl Brownings Toxicity and Metabolism of Industrial Solvents.
REMARK: UN has classified as sub-risk 8 - corrosive.
EXPERT JUDGEMENT: This is probably a severe eye ... | null | NZ_CCID | 1 | CC(C)CNCC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/8085 | PubChem | CC(C)CNCC(C)C | Train |
JP_CHRIP:
1,1'-iminodipropan-2-ol; di-isopropanolamine | JP_CHRIP:
1,1'-Iminodi-2-propanol
Bis(2-propanol) amine
diisopropanolamine
DIPA | 110-97-4 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0170e.html | JP_CHRIP:
There are several reports that the application of the substance to abraded or intact sites of rabbit skin caused moderate or slight hyperemia (IUCLID (2000); HSDB (2006)), or the application to abraded sites caused moderate denaturation (IUCLID (2000); HSDB (2006)). Furthermore, in Draize tests using rabbits,... | null | JP_CHRIP | 1 | CC(O)CNCC(C)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.102K | J-GLOBAL | CC(O)CNCC(C)O | Train |
JP_CHRIP:
heptanoic acid
NZ_CCID:
Heptanoic acid | JP_CHRIP:
Enanthic acid
n-Heptoic acid
n-Heptylic acid | 111-14-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0171e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB329A3C-A115-48A2-9A1B-217426CCA37F | JP_CHRIP:
Rabbits were exposed to the substance for 4 hours, and as a result, treated subjects, as a whole, were graded 5.6 on a scale of 1 to 8 of the primary irritation index, indicating that the substance is corrosive (Patty 5th, 2001). Based on these results, the substance was classified into Category 1. It is rate... | null | JP_CHRIP, NZ_CCID | 2 | CCCCCCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.985B | J-GLOBAL | CCCCCCC(=O)O | Train |
EU_REACH:
[6-(dimethylamino)hexyl]dimethylamine | null | 111-18-2 | 1 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11920/7/4/2/?documentUUID=abaa9300-517a-409f-854a-5cf660535b57 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CN(C)CCCCCCN(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/8097 | PubChem | CN(C)CCCCCCN(C)C | Train |
NZ_CCID:
Sebacoyl dichloride | null | 111-19-3 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/667545F7-4B26-4C4C-9D45-F80090947A96 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCCCC(=O)Cl)CCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66072 | PubChem | O=C(Cl)CCCCCCCCC(=O)Cl | Train |
EU_REACH:
tetraethenylsilane | null | 1112-55-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24943/7/4/2/?documentUUID=5dd459b7-008e-4a43-a735-65d92c8bd0d5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C=C[Si](C=C)(C=C)C=C | https://pubchem.ncbi.nlm.nih.gov/compound/66188 | PubChem | C=C[Si](C=C)(C=C)C=C | Train |
NZ_CCID:
Hexylamine
US_HSDB:
1-Hexylamine | null | 111-26-2 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D7A42524-7B09-4069-BC4C-81B932E204B0
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8444 | NZ_CCID:
Skin Irritation
R PHRASE: R 35 [Company Data]
Eye Irritation
R PHRASE: R 35 [Company Data] | null | NZ_CCID, US_HSDB | 2 | CCCCCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8102 | PubChem | CCCCCCN | Train |
JP_CHRIP:
Glutaraldehyde
KR_NCIS:
Glutaraldehyde
NZ_CCID:
Pentanedial, (glutaraldehyde)
US_HSDB:
Glutaraldehyde | JP_CHRIP:
Glutaraldehyde
1,5-pentanedial
1,5-Pentanedial (50% solution)
Glutaral
glutardialdehyde
Glutaric dialdehyde
Pentanedial
KR_NCIS:
1,5-pentanedial; 1,3-diformylpropane; Glutaral; Glutardialdehyde; Glutaric dialdehyde
NZ_CCID:
1,5-Pentanedial, Glutaral, Glutaraldehyde, Glutardialdehyde, Glutaric acid dialdehyd... | 111-30-8 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2008.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4DEED8F-54FD-4CBB-A0B9-656446DBE6FB
US_HSDB: https://pubchem.ncbi.n... | JP_CHRIP:
【分類根拠】
（１）～（４）より、区分1Bとした。
【根拠データ】
（１）本物質は実験動物の皮膚に対して25％以上の水溶液で刺激性を示す。ヒトの皮膚に付着すると、発赤、水疱を生じるほか、のどや鼻粘膜への刺激症状がみられる。皮膚炎等の防止策として厚生労働省は作業環境気中濃度の最大値の目安を0.05 ppm に設定している（厚労省 リスク評価書 (2015)）。
（２）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、GLP、4時間適用、10日観察）において、適用後24/48/72h後の紅斑スコアの平均は2.8、浮腫スコアの平均は2.6であり、10日後の観察でも壊死と剥離が認められ回復性はみられなかっ... | Provided | JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 4 | O=CCCCC=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.454F | J-GLOBAL | O=CCCCC=O | Train |
JP_CHRIP:
1-Isocyanatobutane | JP_CHRIP:
1-Isocyanatobutane | 111-36-4 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0006e.html | JP_CHRIP:
After occlusive application of 0.5 mL of an undiluted test substance to rabbit ears for 15 or 30 minutes, effects became more serious and the skin was perforated in 1 to 2 days. Surface skin scaling was observed at the end of observation period of 7 days.
On the basis of the evaluation as "highly corrosive" (... | null | JP_CHRIP | 1 | CCCCN=C=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.974H | J-GLOBAL | CCCCN=C=O | Train |
AU_HCIS:
1,2-Ethanediamine, N-(2-aminoethyl)-
JP_CHRIP:
N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine
NZ_CCID:
Diethylene triamine | AU_HCIS:
diethylenetriamine
DETA
ancamine DETA
3-azapentane-1.5-diamine
2,2'-iminobis(ethanamine)
JP_CHRIP:
3-Azapentane-1,5-diamine
Bis(2-aminoethyl)amine
DETA
N-(2-Aminoethyl)-1,2-ethanediamine
NZ_CCID:
1,2-Ethanediamine, N-(2-aminoethyl)-, 1,4,7-Triazaheptane, 1,5-Diamino-3-azapentane, 2-(2-Aminoethylamino)ethylam... | 111-40-0 | 1 | AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=7
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2028e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB07CFC3-E1E7-4577-894F-87F4DD9E9498 | JP_CHRIP:
Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment... | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | NCCNCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.108J | J-GLOBAL | NCCNCCN | Train |
JP_CHRIP:
N-(2-Aminoethyl)-2-aminoethanol
NZ_CCID:
2-(2-Aminoethylamino) ethanol | JP_CHRIP:
2-(2-aminoethylamino)ethanol
Ethanol, 2-[(2-aminoethyl)amino]-
N-(2-aminoethyl)-2-aminoethanol
NZ_CCID:
N-aminoethylethanolamine | 111-41-1 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0081e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E713A4E-89DE-41C3-8C21-DDA1A6910DC0 | JP_CHRIP:
In a test by a semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, necrosis occurred in 2/2 animals after a 4-hour application and 1/4 animals after a 1-hour application, and full-thickness skin necrosis was confirmed by pathological examination (SIDS (2008)). And full-thickne... | null | JP_CHRIP, NZ_CCID | 2 | NCCNCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.188F | J-GLOBAL | NCCNCCO | Train |
JP_CHRIP:
2,2'-thiodiethanol; thiodiglycol | JP_CHRIP:
2,2'-Thiodiethanol
Di(2-hydroxyethyl) sulfide
Diethanolsulfide
Thiodiethylene glycol
Thiodiglycol | 111-48-8 | 0 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0039e.html | JP_CHRIP:
Skin irritation tests using rabbits (complied with OECD guideline 404) concluded that the substance was not an irritant, based on the observation of slight erythema (score 1) in 1 of 3 treated rabbits (SIDS (2004)). From these results, the substance was classified into "Not classified" (also "Not classified" ... | Provided | JP_CHRIP | 1 | OCCSCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.988G | J-GLOBAL | OCCSCCO | Train |
JP_CHRIP:
Hexahydro-1H-azepin
NZ_CCID:
Hexamethyleneimine | JP_CHRIP:
Hexamethylenimine | 111-49-9 | 1 | JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0103e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED5CDB33-85DF-4F51-A46F-8D601369484F | JP_CHRIP:
Since the undiluted substance was dermally corrosive, producing an intact scab after 14 days by occluded application to the skin for 24-hour in an acute dermal toxicity test in rabbits (HSDB (2003)), the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irri... | null | JP_CHRIP, NZ_CCID | 2 | C1CCCNCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J22.113I | J-GLOBAL | C1CCCNCC1 | Train |
NZ_CCID:
Adipoyl dichloride | null | 111-50-2 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7BEAA83C-BC76-4D17-9707-03DC183E614A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCC(=O)Cl)CC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/61034 | PubChem | O=C(Cl)CCCCC(=O)Cl | Train |
EU_REACH:
1,4-diethyl 2-acetylbutanedioate | null | 1115-30-6 | 0 | EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18399/7/4/2/?documentUUID=bd427c12-7b4b-4bf3-89ea-99a4ec6eea8d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)CC(C(=O)C)C(=O)OCC | https://pubchem.ncbi.nlm.nih.gov/compound/66197 | PubChem | CCOC(=O)CC(C(C)=O)C(=O)OCC | Train |
NZ_CCID:
Triisobutylamine | NZ_CCID:
1-Propanamine, 2-methyl-N,N-bis(2-methylpropyl)- | 1116-40-1 | 1 | NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A4406924-5585-431C-ABD5-5B23859590CD | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CC(C)CN(CC(C)C)CC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/14222 | PubChem | CC(C)CN(CC(C)C)CC(C)C | Train |
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