id int64 0 499 | input stringlengths 2.9k 4.9k | gold_index int64 0 12 | options stringclasses 1
value | label stringclasses 12
values |
|---|---|---|---|---|
0 | Activation of endogenous somatostatin receptor subtype 2 (sst2) by somatostatin-14 or activation of transiently transfected << rat D2 dopamine receptors >> (rD2(long)) by [[ quinpirole ]] had no effect.
Query: What is the relation? activator
Pretreatment of the tissues with combined << 5-HT1 >>/5-HT2 antagonists, meth... | 2 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-downregulator |
1 | Regarding the sentence "Abstract 1. We investigated the effects of the dose of and the number of times an inducer was administered and the duration of induction of hepatic and intestinal cytochrome P450 3A (CYP3A) in rats using dexamethasone 21-phosphate (DEX-P) and << midazolam >> (MDZ) as an inducer and a substrate t... | 3 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | activator |
2 | Thus, in 158N cells, the ability of << oxysterols >> to trigger a mode of cell death by apoptosis involving [[ GSK-3 ]] and caspase-3 activation is independent of the increase in the Ca(2+) level and of their accumulation in lipid raft microdomains.
Question: what is the relation?
Answer: activator
The results suggest... | 11 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | antagonist |
3 | Consider the text "Pretreatment of the tissues with combined 5-HT1/<< 5-HT2 >> antagonists, methysergide (1 microM) or methiothepin (0.1 microM), significantly attenuated the inhibitory effect of [[ epinastine ]] on the noncholinergic contraction.". Can you identify the relation? agonist-inhibitor
Consider the text "<... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
4 | Consider the text "<< Phenylephrine >> elicited a concentration-dependent positive inotropic effect via [[ alpha 1-adrenoceptors ]] in the presence of either (+/-)-bupranolol or S(-)-timolol.". Can you identify the relation? agonist-activator
Consider the text "One of the enzymes responsible for the production of KA, ... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
5 | Regarding "Here, we have now found that activation of p38 MAPK by << anisomycin >> potentiated induction of [[ CYP2B6 ]] mRNA by CAR ligand in HepG2 cells to levels observed in ligand-treated human primary hepatocytes.", can you determine the relation? indirect-upregulator
Regarding "PGE(2) is synthesized from << arac... | 10 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | agonist |
6 | Regarding "Fisetin treatment inhibited adipocyte differentiation, consistent with the negative effect of << fisetin >> on [[ mTOR ]].", can you determine the relation? downregulator
Regarding "The lysosomal inhibitor << chloroquine >> significantly increased [[ RCAN1 ]] accumulation in +/+ cells, consistent with the h... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
7 | Given the text "<< Carnitine acetyltransferases >> (CrAT) catalyze the reversible conversion of acetyl-CoA and [[ carnitine ]] to acetylcarnitine and free CoA.", describe the relation. substrate_product-of
Given the text "The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
8 | Consider the text "In addition, << ethanol >> induced degradation of DNA methyltransferases (DNMT-1, DNMT-3a, and DNMT-3b), as well as the methyl CpG-binding proteins ([[ MeCP-2 ]], MBD-2 and MBD-3), in MEF cells by the proteasomal pathway.". Can you identify the relation? downregulator
Consider the text "Type 2 11β-h... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
9 | The results suggested that both the EtOAc extract and << berberine >> were able to activate [[ PPARα/β/γ ]], and Rhizoma Coptis contains potential natural agonists of PPARs besides berberine.
Please explain the relation. agonist-activator
The << bupropion >> metabolic ratio appears to detect known differences in [[ CY... | 0 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | product-of |
10 | Regarding "Nitrogen-containing << bisphosphonates >> induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and [[ Bim ]]-mediated activation of the intrinsic apoptotic pathway.", can you determine the relation? activator
Regarding "However, combined treatment with << cinobufagin >> and... | 11 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | antagonist |
11 | << Orlistat >> is a new inhibitor of [[ pancreatic lipase ]] enzyme.
Please explain the relation. inhibitor
Pre-clinical pharmacology of << zolmitriptan >> (Zomig; formerly 311C90), a centrally and peripherally acting [[ 5HT1B/1D ]] agonist for migraine.
Please explain the relation. agonist
These results suggest that... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
12 | In contrast, the << D-1997 >>-induced responses were potently and concentration-dependently antagonized by the mixed [[ 5-HT1-like ]] and 5-HT2 receptor antagonist methiothepin (0.01-1 microM).
Please explain the relation. agonist
In conclusion, fenoterol-induced constitutive << beta(2)-adrenoceptor >> activity reduce... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
13 | In reference to "The involvement of EP1 and EP2 receptors is indicated by studies with the << EP1 >> selective agonist [[ 17-phenyl trinor PGE2 ]], and the EP2 selective agonist butaprost (which stimulate), as well as by studies with the antagonists SC-51089 (EP1 specific) and AH 6809 (EP1 and EP2 specific).", what is ... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
14 | The esterified-BM, however, had only partial transactivation agonistic activity in cells transfected with << rat GR >>, whereas BM and esterified-[[ DEX ]] had full transactivation agonistic activity.
what is the relation? agonist-activator
Binding of the agonist angiotensin II (AngII) and inverse agonist << losartan ... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
15 | Consider the text "<< DXM >> and 1400W attenuated the mRNA expression of E-selectin and [[ iNOS ]] induced by the costimulation of reIL-4, reTNF-alpha, and LPS.". Can you identify the relation? indirect-downregulator
Consider the text "In the CCl4 hepatotoxicity model, pre-treatment with PSM or << silymarin >> resulte... | 3 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | activator |
16 | Given the text "Many clinical studies, both pre- and post-marketing, have demonstrated the clinical efficacy and safety of sildenafil (<< Viagra >>, Pfizer) - the first approved selective [[ PDE ]] inhibitor for the treatment of ED.", describe the relation. inhibitor
Given the text "One of the enzymes responsible for ... | 10 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | agonist |
17 | Question: What is the relation in the sentence "The values of mean corpuscular << hemoglobin >> concentration and mean corpuscular hemoglobin increased in the [[ STX ]] group."? indirect-upregulator
Question: What is the relation in the sentence "MXF or << VP-16 >> slightly affected cellular topo II activity in nuclea... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
18 | Regarding the sentence "The data show that CP[c]Ph is less potent at inducing << CYP1A >> gene expression in rainbow trout than benzo[a]pyrene ([[ B[a]P ]]), a well-known Ah-receptor agonist.", what is the relation? indirect-upregulator
Regarding the sentence "Pretreatment of the tissues with combined 5-HT1/<< 5-HT2 >... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
19 | OBJECTIVES: The aim of this study was to determine whether cocaine's sympathomimetic actions can be reversed by a potent centrally acting alpha2 adrenergic receptor (<< AR >>) agonist ([[ dexmedetomidine ]]).
Question: what is the relation?
Answer: agonist
Binding of the agonist angiotensin II (AngII) and inverse agon... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
20 | Regarding the sentence "In conclusion, fenoterol-induced constitutive << beta(2)-adrenoceptor >> activity reduces muscarinic receptor agonist- and histamine-induced contractions of bovine tracheal smooth muscle, which can be reversed by the inverse agonist [[ timolol ]].", what is the relation? agonist-inhibitor
Regar... | 2 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-downregulator |
21 | Regarding the sentence "The treatment with << arsenic >> exhibited a significant increase in some serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, [[ alkaline phosphatase ]], total protein, albumin, bilirubin, cholesterol, urea and creatinine).", what is the relation... | 4 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-upregulator |
22 | Regarding the sentence "In vitro, V(5+) decreased the << TCDD >>-mediated induction of [[ Cyp1a1 ]] mRNA, protein, and catalytic activity levels.", what is the relation? indirect-upregulator
Regarding the sentence "Pyrrolidine dithiocarbamate (<< PDTC >>), a specific NF-κB inhibitor, along with 20S proteasome inhibito... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
23 | In reference to "On the basis of data obtained in rabbits, the imidazoline receptor ligand << rilmenidine >> has been suggested to decrease blood pressure in humans by activating central [[ alpha(2A)-adrenoceptors ]].", what is the relation? upregulator
In reference to "Terbutaline (Bricanyl) and its prodrug << Bambut... | 2 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-downregulator |
24 | Abstract 1. We investigated the effects of the dose of and the number of times an inducer was administered and the duration of induction of hepatic and intestinal cytochrome P450 3A (<< CYP3A >>) in rats using [[ dexamethasone 21-phosphate ]] (DEX-P) and midazolam (MDZ) as an inducer and a substrate to CYP3A, respectiv... | 2 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-downregulator |
25 | Labetalol (> or = 3 x 10(-8) M) and dilevalol (> or = 10(-8) M) caused surmountable antagonism of the << isoprenaline >> responses of the atria and the pA2 values were 8.60 and 8.98 at the [[ beta 1-adrenoceptors ]] of the rat left atria and 7.90 and 8.31, respectively, on the guinea-pig left atria which has functional... | 11 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | antagonist |
26 | Consider the text "RESULTS: Ketorolac was six times more active against << COX-1 >> (IC(50) = 0.02 microM) than COX-2 (IC(50) = 0.12 microM) while [[ bromfenac ]] was approximately 32 times more active against COX-2 (IC(50) = 0.0066 microM) than COX-1 (IC(50) = 0.210 microM).". Can you identify the relation? downregula... | 11 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | antagonist |
27 | The beta-adrenergic/<< 5-HT1A >> receptor antagonist [[ (+/-)pindolol ]] and the selective 5-HT1B/D antagonist GR127935 produced no significant augmentation of venlafaxine-induced changes in either 5-HT or NA.
Please explain the relation. antagonist
The recent development of << H1-receptor >> antagonists devoid of cli... | 3 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | activator |
28 | << Pinosylvin >> was also found to attenuate the activation of proteins involved in focal adhesion kinase (FAK)/c-Src/extracellular signal-regulated kinase (ERK) signaling, and phosphoinositide 3-kinase (PI3K)/Akt/ [[ glycogen synthase kinase 3β ]] (GSK-3β) signaling pathway.
what is the relation? indirect-downregulato... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
29 | Question: What is the relation in the sentence "The esterified-<< BM >>, however, had only partial transactivation agonistic activity in cells transfected with [[ rat GR ]], whereas BM and esterified-DEX had full transactivation agonistic activity."? agonist
Question: What is the relation in the sentence "One of the e... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
30 | Question: What is the relation in the sentence "<< Aliskiren >> represents the first in a novel class of [[ renin ]] inhibitors with the potential for treatment of hypertension and related cardiovascular diseases."? inhibitor
Question: What is the relation in the sentence "Although the treatment with MSG increased IRS... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
31 | Second, << probucol >>, an antiatherogenic compound reported to be an inactivator of [[ ABCA1 ]] reduced hepatic alpha-tocopherol secretion.
Question: what is the relation?
Answer: downregulator
The effects of D-1997 in the basilar artery were not modified by incubation with either the 5-HT2 receptor antagonist ketans... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
32 | RESULTS: << DRF 2655 >> showed concentration-dependent transactivation of PPARalpha and [[ PPARgamma ]].
what is the relation? agonist-activator
Extracellular application of << meclofenamate >> (EC(50) = 25 microM) and diclofenac (EC(50) = 2.6 microM) resulted in the activation of [[ KCNQ2/Q3 ]] K(+) currents, heterol... | 4 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-upregulator |
33 | Regarding "These findings suggest that << S1P >> activates the PI3K/Akt signaling pathway leading to the promotion of nuclear translocation of β-catenin in osteoblast-like cells, resulting in the upregulation of [[ osteoptotegerin ]] and osteoblast differentiation markers including alkaline phosphatase, probably relati... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
34 | Question: What is the relation in the sentence "To this end, 158N murine oligodendrocytes were treated with 7KC or << 7βOHC >> inducing an apoptotic mode of cell death characterized by condensation/fragmentation of the nuclei, dephosphorylation of Akt and GSK3, mitochondrial depolarization involving [[ Mcl-1 ]], and ca... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
35 | Question: What is the relation in the sentence "<< Fisetin >> treatment showed a significant decline in the levels of blood glucose, glycosylated hemoglobin (HbA1c), [[ NF-kB ]] p65 unit (in pancreas) and IL-1β (plasma), serum nitric oxide (NO) with an elevation in plasma insulin."? indirect-downregulator
Question: Wh... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
36 | Given the text "Different substrates were used as the relative specific substrates for the determination of aminopeptidase enzymatic activity: 4-methoxy-2-naphthylamide of L-alanine for aminopeptidase N, 4-methoxy-2-naphthylamide of << L-leucine >> for [[ leucine aminopeptidase ]], 4-methoxy-2-naphthylamide of L-glutam... | 2 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-downregulator |
37 | Regarding "Ten IU/mL urokinase was also incubated with pooled plasma of stroke patients, that was previously oxidized with the singlet oxygen (<< 1O2 >>) donor chloramine T (CT), to destroy [[ plasmatic PAI-1 ]] and alpha2-antiplasmin.", can you determine the relation? downregulator
Regarding "In conclusion, fenoterol... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
38 | The potent << histamine H(1)-receptor >> antagonist cetirizine (Zyrtec) is a racemic mixture of levocetirizine (now available under the trademark Xyzal and [[ dextrocetirizine ]].
Query: What is the relation? antagonist
Type 2 11β-hydroxysteroid dehydrogenase encoded by the << HSD11B2 >> gene converts cortisol to inac... | 5 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | substrate |
39 | Consider the text "RESULTS: << DRF 2655 >> showed concentration-dependent transactivation of PPARalpha and [[ PPARgamma ]].". Can you identify the relation? agonist-activator
Consider the text "Liver << BHMT >> activity was 1.3-fold higher in rats fed the Met deficient diet containing [[ choline ]], which was reflecte... | 12 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | agonist-inhibitor |
40 | The results suggested that both the EtOAc extract and << berberine >> were able to activate [[ PPARα/β/γ ]], and Rhizoma Coptis contains potential natural agonists of PPARs besides berberine.
Please explain the relation. agonist-activator
The ARB << eprosartan >> is a nonbiphenyl nontetrazole [[ angiotensin II type 1 ... | 4 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-upregulator |
41 | Furthermore, N-<< BPs >> decreased the levels of phosphorylated extracellular signal-regulated kinase (ERK) and mTOR via suppression of [[ Ras ]] prenylation and enhanced Bim expression.
Query: What is the relation? inhibitor
One of the enzymes responsible for the production of KA, kynurenine aminotransferase I (KATI)... | 2 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | indirect-downregulator |
42 | The involvement of EP1 and EP2 receptors is indicated by studies with the EP1 selective agonist 17-phenyl trinor PGE2, and the << EP2 >> selective agonist [[ butaprost ]] (which stimulate), as well as by studies with the antagonists SC-51089 (EP1 specific) and AH 6809 (EP1 and EP2 specific).
what is the relation? agoni... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
43 | Type 2 11β-hydroxysteroid dehydrogenase encoded by the << HSD11B2 >> gene converts cortisol to inactive [[ cortisone ]], and alteration in this enzymatic activity might affect glucose homeostasis by affecting circulating levels or tissue availability of glucocorticoids.
Question: what is the relation?
Answer: substrate... | 3 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | activator |
44 | In support of the hypothesis that TCDD decreases canonical Wnt signaling, we identify inhibitory effects of TCDD on multiple components of the canonical Wnt signaling pathway in the UGS that temporally coincide with the inhibitory effect of << TCDD >> on prostatic bud formation: (1) expression of [[ R-spondins ]] (Rspo... | 7 | ['product-of', 'substrate_product-of', 'indirect-downregulator', 'activator', 'indirect-upregulator', 'substrate', 'upregulator', 'inhibitor', 'agonist-activator', 'downregulator', 'agonist', 'antagonist', 'agonist-inhibitor'] | inhibitor |
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