Sequence To Structured Output Tasks
Collection
NER, Information Extraction • 3 items • Updated
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Title : Oseltamivir for coronavirus illness : post - hoc exploratory analysis of an open - label , pragmatic , randomised controlled trial in European primary care from 2016 to 2018 . METHODS : Exploratory analysis of data from an open - label , pragmatic , randomised controlled trial during three influenza seasons , f... | {
"P": [
"Patients aged ?1 year presenting to primary care with influenza - like illness ( ILI ) , and who tested positive for coronavirus ( not including SARS - CoV - 2 )"
],
"I": [
"Oseltamivir",
"usual care",
"oseltamivir"
],
"C": [
"usual care"
],
"O": [
"time to recovery",
... |
Title : The effect of propolis supplementation on clinical symptoms in patients with coronavirus ( COVID - 19 ) : A structured summary of a study protocol for a randomised controlled trial . METHODS : This is a Double - Blind , Placebo - Controlled , Parallel Arm , Randomized Phase ?? Clinical Trial . Patients with the... | {
"P": [
"patients with coronavirus",
"Patients with the confirmed COVID - 19 based on the PCR test are eligible to participate in the trial if they are 18 to 75 years of age and have no history of the current use of warfarin or propolis supplement and presence of sensitivity to bee products"
],
"I": [
... |
Title : COvid - 19 and high - dose VITamin D supplementation TRIAL in high - risk older patients ( COVIT - TRIAL ) : study protocol for a randomized controlled trial . METHODS : The COVIT - TRIAL study is an open - label , multicenter , randomized controlled superiority trial . Patients aged ? 65 years with COVID - 19 ... | {
"P": [
"high - risk older patients",
"Patients aged ? 65 years with COVID - 19 ( diagnosed within the preceding 3 days with RT - PCR and / or chest CT scan ) and at least one worsening risk factor at the time of inclusion ( i . e . , age ? 75 years , or SpO2 ? 94 % in room air , or PaO2 / FiO2 ? 300 mmHg ) ... |
Title : Metoprolol in Critically Ill Patients With COVID - 19 . METHODS : A total of 20 COVID - 19 patients with ARDS on invasive mechanical ventilation were randomized to metoprolol ( 15 mg daily for 3 days ) or control ( no treatment ) . All patients underwent bronchoalveolar lavage ( BAL ) before and after metoprolo... | {
"P": [
"Critically Ill Patients With COVID - 19",
"A total of 20 COVID - 19 patients with ARDS on invasive mechanical ventilation"
],
"I": [
"Metoprolol",
"metoprolol"
],
"C": [
"no treatment"
],
"O": [
"invasive hemodynamic",
"electrocardiogram monitoring",
"echocardiogr... |
Title : Efficacy and safety of pegylated interferon alfa - 2 b in moderate COVID - 19 : A phase II , randomized , controlled , open - label study . METHODS : In this phase 2 , randomized , open - label study , adult subjects aged ?18 years with RT - PCR confirmed COVID - 19 with moderate symptoms were randomized in a 1... | {
"P": [
"adult subjects aged ?18 years with RT - PCR confirmed COVID - 19 with moderate symptoms"
],
"I": [
"pegylated interferon alfa - 2 b",
"PEG IFN - ?2b",
"SOC"
],
"C": [
"SOC alone"
],
"O": [
"clinical status",
"the WHO 7 - point ordinal scale"
]
} |
Title : Homemade valved holding chambers for children with airway hyperresponsiveness : A randomized crossover trial . METHODS : In a randomized , two - period , two - sequence crossover trial , we recruited 20 children , aged 6 - 15 years , who had a greater than 12 % increase in FEV1 after inhaled salbutamol . They w... | {
"P": [
"children with airway hyperresponsiveness",
"20 children , aged 6 - 15 years , who had a greater than 12 % increase in FEV1 after inhaled salbutamol"
],
"I": [
"Homemade valved holding chambers",
"our VHC",
"Aerochamber",
"the same VHCs",
"those VHCs"
],
"C": [],
"O": [
... |
Title : Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid - 19 . METHODS : In this open - label , adaptive , multiplatform , controlled trial , we randomly assigned patients who were hospitalized with Covid - 19 and who were not critically ill ( which was defined as an absence of critica... | {
"P": [
"Noncritically Ill Patients with Covid - 19",
"patients who were hospitalized with Covid - 19 and who were not critically ill ( which was defined as an absence of critical care - level organ support at enrollment )"
],
"I": [
"Heparin",
"therapeutic - dose anticoagulation with heparin"
... |
Title : Combined use of a broad - panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community - acquired pneumonia ( MULTI - CAP ) : a multicentre , parallel - group , open - label , individual randomised trial conducted in French intensive care units .... | {
"P": [
"patients with severe community - acquired pneumonia",
"patients with severe - CAP ( MULTI - CAP ) trial",
"adult admitted to intensive care unit for a CAP"
],
"I": [
"a broad - panel respiratory multiplex PCR",
"procalcitonin",
"The multiplex PCR",
"experimental strategy",
... |
Title : Ivermectin to prevent hospitalizations in patients with COVID - 19 ( IVERCOR - COVID19 ) a randomized , double - blind , placebo - controlled trial . METHODS : A randomized , double - blind , placebo - controlled study was conducted in non - hospitalized individuals with COVID - 19 in Corrientes , Argentina . P... | {
"P": [
"patients with COVID - 19",
"non - hospitalized individuals with COVID - 19 in Corrientes , Argentina",
"Patients with SARS - CoV - 2 positive nasal swabs",
"501 patients between August 19 th 2020 and February 22 nd 2021"
],
"I": [
"Ivermectin",
"ivermectin"
],
"C": [
"pla... |
Title : Effect of Recombinant Human Granulocyte Colony - Stimulating Factor for Patients With Coronavirus Disease 2019 ( COVID - 19 ) and Lymphopenia : A Randomized Clinical Trial . METHODS : Between February 18 and April 10 , 2020 , we conducted an open - label , multicenter , randomized clinical trial at 3 participat... | {
"P": [
"Patients With Coronavirus Disease 2019 ( COVID - 19 ) and Lymphopenia"
],
"I": [
"Recombinant Human Granulocyte Colony",
"usual care",
"3 doses of recombinant human granulocyte colony - stimulating factor ( rhG - CSF"
],
"C": [
"Usual care alone"
],
"O": [
"the time from ... |
Title : Hydroxychloroquine in mild - to - moderate coronavirus disease 2019 : a placebo - controlled double blind trial . METHODS : We conducted a multicentre randomized double - blind placebo - controlled trial evaluating hydroxychloroquine in COVID - 19 patients with at least one of the following risk factors for wor... | {
"P": [
"COVID - 19 patients with at least one of the following risk factors for worsening : need for supplemental oxygen , age ?75 years , age between 60 and 74 years and presence of at least one co - morbidity"
],
"I": [
"Hydroxychloroquine",
"hydroxychloroquine",
"800 mg hydroxychloroquine"
... |
Title : Comparison of losartan and amlodipine effects on the outcomes of patient with COVID - 19 and primary hypertension : A randomised clinical trial . METHODS : In this randomised clinical trial , hospitalised patients with COVID - 19 and primary HTN were enrolled in the study . One arm received losartan , 25 mg , t... | {
"P": [
"patient with COVID - 19 and primary hypertension",
"hospitalised patients with COVID - 19 and primary HTN"
],
"I": [
"losartan",
"amlodipine"
],
"C": [],
"O": [
"compare 30 - day mortality rate",
"length of hospital stay"
]
} |
Title : Cytokine adsorption in patients with severe COVID - 19 pneumonia requiring extracorporeal membrane oxygenation ( CYCOV ) : a single centre , open - label , randomised , controlled trial . METHODS : We did a single - centre , open - label , randomised , controlled trial to investigate cytokine adsorption in adul... | {
"P": [
"patients with severe COVID - 19 pneumonia requiring extracorporeal membrane oxygenation",
"adult patients with severe COVID - 19 pneumonia requiring ECMO",
"Patients with COVID - 19 selected for ECMO at the Freiburg University Medical Center ( Freiburg , Germany )"
],
"I": [
"Cytokine ad... |
Title : Magnesium treatment on methylation changes of transmembrane serine protease 2 ( TMPRSS2 ) . METHODS : This study is nested within the Personalized Prevention of Colorectal Cancer Trial , a double - blind 2 O 2 factorial randomized controlled trial , which enrolled 250 participants from Vanderbilt University Med... | {
"P": [
"250 participants from Vanderbilt University Medical Center"
],
"I": [
"Magnesium treatment"
],
"C": [],
"O": []
} |
Title : Hydroxychloroquine with or without Azithromycin in Mild - to - Moderate Covid - 19 . METHODS : We conducted a multicenter , randomized , open - label , three - group , controlled trial involving hospitalized patients with suspected or confirmed Covid - 19 who were receiving either no supplemental oxygen or a ma... | {
"P": [
"hospitalized patients with suspected or confirmed Covid - 19 who were receiving either no supplemental oxygen or a maximum of 4 liters per minute of supplemental oxygen"
],
"I": [
"Hydroxychloroquine",
"Azithromycin",
"standard care",
"hydroxychloroquine",
"azithromycin"
],
"... |
Title : Safety and efficacy of Favipiravir in moderate to severe SARS - CoV - 2 pneumonia . METHODS : We did a multicenter randomized open - labeled clinical trial on moderate to severe cases infections of SARS - CoV - 2 . Patients with typical ground glass appearance on chest computerized tomography scan ( CT scan ) a... | {
"P": [
"Patients with typical ground glass appearance on chest computerized tomography scan ( CT scan ) and oxygen saturation ( SpO2 ) of less than 93 %"
],
"I": [
"Favipiravir",
"Lopinavir",
"Ritonavir",
"standard care"
],
"C": [],
"O": [
"In - hospital mortality",
"ICU admiss... |
Title : Effect of Canakinumab vs Placebo on Survival Without Invasive Mechanical Ventilation in Patients Hospitalized With Severe COVID - 19 : A Randomized Clinical Trial . METHODS : This randomized , double - blind , placebo - controlled phase 3 trial was conducted at 39 hospitals in Europe and the United States . A t... | {
"P": [
"Patients Hospitalized With Severe COVID - 19",
"A total of 454 hospitalized patients with COVID - 19 pneumonia , hypoxia ( not requiring invasive mechanical ventilation [ IMV ] ) , and systemic hyperinflammation defined by increased blood concentrations of C - reactive protein or ferritin"
],
"I... |
Title : A randomized trial in the investigation of anxiety and depression in patients with coronavirus disease 2019 ( COVID - 19 ) . METHODS : Sixty - five COVID - 19 patients were randomly enrolled into this study . Anxiety and depression among participants were measured through the completion of anonymous Chinese - l... | {
"P": [
"patients with coronavirus disease 2019 ( COVID - 19 )",
"Sixty - five COVID - 19 patients"
],
"I": [],
"C": [],
"O": [
"Anxiety",
"depression",
"anonymous Chinese - language Zung self - rating anxiety scale",
"self - rating depression scale questionnaires"
]
} |
Title : A Phase II Safety and Efficacy Study on Prognosis of Moderate Pneumonia in Coronavirus Disease 2019 Patients With Regular Intravenous Immunoglobulin Therapy . METHODS : An open - label , multicenter , comparative , randomized study was conducted on COVID - 19 patients with moderate pneumonia . One hundred eligi... | {
"P": [
"Coronavirus Disease 2019 Patients",
"COVID - 19 patients with moderate pneumonia",
"One hundred eligible patients"
],
"I": [
"Regular Intravenous Immunoglobulin Therapy",
"IVIG",
"standard of care ( SOC )"
],
"C": [
"SOC"
],
"O": []
} |
Title : A Randomized Trial of Convalescent Plasma in Covid - 19 Severe Pneumonia . METHODS : We randomly assigned hospitalized adult patients with severe Covid - 19 pneumonia in a 2 : 1 ratio to receive convalescent plasma or placebo . The primary outcome was the patient ' s clinical status 30 days after the interventi... | {
"P": [
"hospitalized adult patients with severe Covid - 19 pneumonia"
],
"I": [
"Convalescent Plasma",
"convalescent plasma"
],
"C": [
"placebo"
],
"O": [
"the patient ' s clinical status",
"a six - point ordinal scale"
]
} |
Title : SARS - CoV - 2 clearance in COVID - 19 patients with Novaferon treatment : A randomized , open - label , parallel - group trial . METHODS : In the laboratory , Novaferon ' s inhibition of viral replication in cells infected with SARS - CoV - 2 , and prevention of SARS - CoV - 2 entry into healthy cells was dete... | {
"P": [
"COVID - 19 patients"
],
"I": [
"Novaferon",
"Lopinavir",
"Ritonavir"
],
"C": [],
"O": [
"the SARS - CoV - 2 clearance rates",
"the time to SARS - CoV - 2 clearance"
]
} |
Title : Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID - 19 : A Randomized Clinical Trial . METHODS : This was a multicenter , double - blind , randomized , placebo - controlled trial conducted in 2 sites in Sao Paulo , Brazil . The study included 240 hos... | {
"P": [
"Patients With Moderate to Severe COVID - 19",
"240 hospitalized patients with COVID - 19 who were moderately to severely ill at the time of enrollment from June 2 , 2020 , to August 27 , 2020 . The final follow - up was on October 7 , 2020"
],
"I": [
"a Single High Dose of Vitamin D3",
"... |
Title : Sofosbuvir and daclatasvir for the treatment of COVID - 19 outpatients : a double - blind , randomized controlled trial . METHODS : This was a randomized controlled clinical trial in outpatients with mild COVID - 19 . Patients were randomized into a treatment arm receiving sofosbuvir / daclatasvir plus hydroxyc... | {
"P": [
"COVID - 19 outpatients",
"outpatients with mild COVID - 19"
],
"I": [
"Sofosbuvir",
"daclatasvir",
"sofosbuvir",
"hydroxychloroquine"
],
"C": [
"hydroxychloroquine alone"
],
"O": [
"symptom alleviation",
"hospital admission",
"Fatigue",
"dyspnoea",
... |
Title : The Humanoid Robot Sil - Bot in a Cognitive Training Program for Community - Dwelling Elderly People with Mild Cognitive Impairment during the COVID - 19 Pandemic : A Randomized Controlled Trial . METHODS : A randomized controlled trial was conducted with 135 volunteers without cognitive impairment aged 60 year... | {
"P": [
"Community - Dwelling Elderly People with Mild Cognitive Impairment during the COVID - 19 Pandemic",
"135 volunteers without cognitive impairment aged 60 years old or older"
],
"I": [
"The Humanoid Robot Sil - Bot in a Cognitive Training Program",
"cognitive training",
"The cognitive ... |
Title : Effect of Dexamethasone on Days Alive and Ventilator - Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID - 19 : The CoDEX Randomized Clinical Trial . METHODS : Multicenter , randomized , open - label , clinical trial conducted in 41 intensive care units ( ICUs ) in Brazil . ... | {
"P": [
"Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID - 19",
"Patients with COVID - 19 and moderate to severe ARDS , according to the Berlin definition"
],
"I": [
"Dexamethasone",
"Twenty mg of dexamethasone",
"10 mg of dexamethasone",
"standard care"
]... |
Title : Rationale and design for the study of rivaroxaban to reduce thrombotic events , hospitalization and death in outpatients with COVID - 19 : The PREVENT - HD study . METHODS : PREVENT - HD is a double - blind , placebo - controlled , pragmatic , event - driven phase 3 trial to evaluate the efficacy and safety of ... | {
"P": [
"outpatients with COVID - 19",
"symptomatic outpatients with laboratory - confirmed COVID - 19 at risk for thrombotic events , hospitalization , and death"
],
"I": [
"rivaroxaban"
],
"C": [
"placebo"
],
"O": [
"a composite of symptomatic venous thromboembolism",
"myocardia... |
Title : Traditional Chinese medicine shenhuang granule in patients with severe / critical COVID - 19 : A randomized controlled multicenter trial . METHODS : This was an open - label , multicenter , randomized , controlled clinical trial . At 4 medical centers , a total of 111 severe / critical patients were randomly as... | {
"P": [
"patients with severe / critical COVID - 19",
"a total of 111 severe / critical patients"
],
"I": [
"Traditional Chinese medicine shenhuang granule",
"Shenhuang Granule",
"SHG",
"standard care"
],
"C": [
"standard care alone"
],
"O": []
} |
Title : Efficacy and safety of sofosbuvir / ledipasvir in treatment of patients with COVID - 19 ; A randomized clinical trial . METHODS : Among an open - label randomized clinical trial , 82 patients with mild to moderated COVID - 19 were assigned to receive either SOF / LDP 400 / 100 mg daily plus the standard of care... | {
"P": [
"patients with COVID - 19",
"82 patients with mild to moderated COVID - 19"
],
"I": [
"sofosbuvir",
"ledipasvir",
"SOF",
"LDP",
"the standard of care"
],
"C": [
"the standard of care alone"
],
"O": [
"Time to clinical response",
"rate of clinical response",... |
Title : Umbilical Cord - derived Mesenchymal Stem Cells modulate TNF and soluble TNF Receptor 2 ( sTNFR2 ) in COVID - 19 ARDS patients . METHODS : We analyzed plasma samples from subjects with COVID - 19 ARDS ( n=24 ) enrolled in a Phase 1 / 2 a randomized controlled trial of UC - MSC treatment . Plasma samples were ob... | {
"P": [
"COVID - 19 ARDS patients",
"subjects with COVID - 19 ARDS ( n=24 )"
],
"I": [
"Umbilical Cord - derived Mesenchymal Stem Cells",
"UC - MSC treatment"
],
"C": [],
"O": [
"Plasma concentrations of sTNFR2",
"TNF?",
"a quantitative multiplex protein array"
]
} |
Title : Chloroquine nasal drops in asymptomatic & mild COVID - 19 : An exploratory randomized clinical trial . METHODS : This randomized clinical trial was done with a sample size of 60 . Reverse transcription - polymerase chain reaction ( RT - PCR ) confirmed asymptomatic patients or those with mild COVID - 19 illness... | {
"P": [
"Reverse transcription - polymerase chain reaction ( RT - PCR ) confirmed asymptomatic patients or those with mild COVID - 19 illness [ National Early Warning Score ( NEWS ) ?4 ]"
],
"I": [
"Chloroquine",
"standard treatment",
"CQN"
],
"C": [
"standard supportive treatment"
],
... |
Title : Favipiravir in the treatment of patients with SARS - CoV - 2 RNA recurrent positive after discharge : A multicenter , open - label , randomized trial . METHODS : This is a multicenter , open - label , randomized controlled trial in SARS - CoV - 2 RNA re - positive patients . Patients were randomly assigned in a... | {
"P": [
"patients with SARS - CoV - 2 RNA recurrent positive after discharge",
"SARS - CoV - 2 RNA re - positive patients"
],
"I": [
"Favipiravir",
"favipiravir",
"standard care"
],
"C": [
"standard care alone"
],
"O": [
"time to achieve a consecutive twice ( at intervals of m... |
Title : Magnesium treatment on methylation changes of transmembrane serine protease 2 ( TMPRSS2 ) . METHODS : This study is nested within the Personalized Prevention of Colorectal Cancer Trial , a double - blind 2 2 factorial randomized controlled trial , which enrolled 250 participants from Vanderbilt University Medic... | {
"P": [
"250 participants from Vanderbilt University Medical Center"
],
"I": [
"Magnesium treatment"
],
"C": [],
"O": []
} |
Title : Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID - 19 in Brazil ( COALITION II ) : a randomised clinical trial . METHODS : We did an open - label , randomised clinical trial at 57 centres in Brazil . We enrolled pa... | {
"P": [
"patients admitted to the hospital with severe COVID - 19 in Brazil",
"patients admitted to hospital with suspected or confirmed COVID - 19"
],
"I": [
"Azithromycin",
"standard of care",
"azithromycin",
"hydroxychloroquine"
],
"C": [
"standard of care alone",
"standard... |
Title : Effects of a 2 - Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid - 19 : A Randomized Clinical Trial . METHODS : A total of 69 reverse transcriptase polymerase chain reaction ( RT - PCR ) SARS - CoV - 2 positive adults who were hospitalized f... | {
"P": [
"Patients with Mild to Moderate Covid - 19",
"A total of 69 reverse transcriptase polymerase chain reaction ( RT - PCR ) SARS - CoV - 2 positive adults who were hospitalized for mild to moderate COVID - 19 disease"
],
"I": [
"a 2 - Week 5000 IU",
"once daily for 2 weeks either 5000 IU ora... |
Title : REGN - COV2 , a Neutralizing Antibody Cocktail , in Outpatients with Covid - 19 . METHODS : In this ongoing , double - blind , phase 1 - 3 trial involving nonhospitalized patients with Covid - 19 , we investigated two fully human , neutralizing monoclonal antibodies against severe acute respiratory syndrome cor... | {
"P": [
"Outpatients with Covid - 19",
"nonhospitalized patients with Covid - 19"
],
"I": [
"REGN - COV2",
"a Neutralizing Antibody Cocktail",
"a combined cocktail",
"2 . 4 g of REGN - COV2",
"8 . 0 g of REGN - COV2"
],
"C": [
"placebo"
],
"O": [
"viral load",
"the... |
Title : A Cluster - Randomized Trial of Hydroxychloroquine for Prevention of Covid - 19 . METHODS : We conducted an open - label , cluster - randomized trial involving asymptomatic contacts of patients with polymerase - chain - reaction ( PCR ) - confirmed Covid - 19 in Catalonia , Spain . We randomly assigned clusters... | {
"P": [
"asymptomatic contacts of patients with polymerase - chain - reaction ( PCR ) - confirmed Covid - 19 in Catalonia , Spain"
],
"I": [
"Hydroxychloroquine",
"the hydroxychloroquine"
],
"C": [
"the usual - care"
],
"O": [
"PCR - confirmed , symptomatic Covid - 19",
"SARS - Co... |
Title : Baricitinib plus Remdesivir for Hospitalized Adults with Covid - 19 . METHODS : We conducted a double - blind , randomized , placebo - controlled trial evaluating baricitinib plus remdesivir in hospitalized adults with Covid - 19 . All the patients received remdesivir ( ?10 days ) and either baricitinib ( ?14 d... | {
"P": [
"Hospitalized Adults with Covid - 19",
"hospitalized adults with Covid - 19"
],
"I": [
"Baricitinib",
"Remdesivir",
"baricitinib",
"remdesivir"
],
"C": [
"placebo"
],
"O": [
"the time to recovery",
"clinical status"
]
} |
Title : Feasibility and outcome of an online streamed yoga intervention on stress and wellbeing of people working from home during COVID - 19 . METHODS : A six - week pilot randomized controlled trial ( RCT ) yoga intervention was designed with yoga ( n = 26 ) and a wait - list control group ( n = 26 ) . A mixed two - ... | {
"P": [
"people working from home during COVID - 19"
],
"I": [
"an online streamed yoga intervention",
"yoga"
],
"C": [
"a wait - list control"
],
"O": [
"Likert",
"open - ended questions",
"enjoyment",
"acceptability",
"perceived benefits of the program"
]
} |
Title : Progesterone in Addition to Standard of Care vs Standard of Care Alone in the Treatment of Men Hospitalized With Moderate to Severe COVID - 19 : A Randomized , Controlled Pilot Trial . METHODS : We conducted a pilot , randomized , open - label , controlled trial of subcutaneous progesterone in men hospitalized ... | {
"P": [
"Men Hospitalized With Moderate to Severe COVID - 19",
"men hospitalized with confirmed moderate to severe COVID - 19"
],
"I": [
"Progesterone",
"Standard of Care",
"subcutaneous progesterone",
"SOC",
"progesterone"
],
"C": [
"Standard of Care Alone",
"SOC alone"
... |
Title : Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID - 19 - associated cytokine storm syndrome : results of the CHIC study . METHODS : From 1 April 2020 , patients with COVID - 19 - associated CSS , defined as rapid respiratory dete... | {
"P": [
"patients with COVID - 19 - associated cytokine storm syndrome",
"patients with COVID - 19 - associated CSS , defined as rapid respiratory deterioration plus at least two out of three biomarkers with important elevations ( C - reactive protein > 100 mg / L ; ferritin > 900 g / L ; D - dimer > 1500 g ... |
Title : The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID - 19 : a pilot cluster randomized parallel - controlled trial . METHODS : This was a pilot cluster randomized parallel - controlled trial with hospital wards as the units of... | {
"P": [
"hospitalized patients with COVID - 19",
"50 consecutive patients who were hospitalized in 2 hospitals in Shiraz , after being diagnosed with COVID - 19"
],
"I": [
"online multimedia psychoeducational interventions",
"Psychoeducational interventions",
"cognitive - behavioural techniqu... |
Title : Double - blind , Randomized , Placebo - controlled Trial With N - acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 ( COVID - 19 ) . METHODS : This was a double - blind , randomized , placebo - controlled , single - center trial conducted at the Emergency Depar... | {
"P": [
"patients with COVID - 19",
"135 patients with severe COVID - 19 ( confirmed or suspected ) , with an oxyhemoglobin saturation < 94 % or respiratory rate > 24 breaths / minute"
],
"I": [
"N - acetylcysteine",
"NAC"
],
"C": [
"dextrose"
],
"O": [
"the need for mechanical ve... |
Title : Early versus deferred anti - SARS - CoV - 2 convalescent plasma in patients admitted for COVID - 19 : A randomized phase II clinical trial . | {
"P": [
"patients admitted for COVID - 19"
],
"I": [
"Early",
"deferred anti - SARS - CoV - 2 convalescent plasma"
],
"C": [],
"O": []
} |
Title : Azithromycin for community treatment of suspected COVID - 19 in people at increased risk of an adverse clinical course in the UK ( PRINCIPLE ) : a randomised , controlled , open - label , adaptive platform trial . METHODS : In this UK - based , primary care , open - label , multi - arm , adaptive platform rando... | {
"P": [
"people at increased risk of an adverse clinical course in the UK",
"people at increased risk of an adverse clinical course",
"people aged 65 years and older , or 50 years and older with at least one comorbidity , who had been unwell for 14 days or less with suspected COVID - 19"
],
"I": [
... |
Title : The impact of sofosbuvir / daclatasvir or ribavirin in patients with severe COVID - 19 . METHODS : Patients with a positive nasopharyngeal swab for SARS - CoV - 2 on RT - PCR or bilateral multi - lobar ground - glass opacity on their chest CT and signs of severe COVID - 19 were included . Subjects were divided ... | {
"P": [
"patients with severe COVID - 19",
"Patients with a positive nasopharyngeal swab for SARS - CoV - 2 on RT - PCR or bilateral multi - lobar ground - glass opacity on their chest CT and signs of severe COVID - 19"
],
"I": [
"sofosbuvir",
"daclatasvir",
"ribavirin",
"the recommended ... |
Title : Efficacy of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in treatment of COVID - 19 : A randomized controlled trial . METHODS : A total of 283 patients participated in this clinical trial , and participants were randomly assigned to receive either 1 ) Huoxiang Zhengqi dropping pills and Lianhua ... | {
"P": [
"A total of 283 patients"
],
"I": [
"Huoxiang Zhengqi dropping pills",
"Lianhua Qingwen granules",
"Linahua granules",
"western medicine"
],
"C": [
"western medicine alone"
],
"O": [
"the improvement",
"resolution rates of clinical symptoms",
"the rate of patie... |
Title : Effect of anakinra versus usual care in adults in hospital with COVID - 19 and mild - to - moderate pneumonia ( CORIMUNO - ANA - 1 ) : a randomised controlled trial . METHODS : In this multicentre , open - label , Bayesian randomised clinical trial ( CORIMUNO - ANA - 1 ) , nested within the CORIMUNO - 19 cohort... | {
"P": [
"adults in hospital with COVID - 19 and mild - to - moderate pneumonia",
"patients from 16 University hospitals in France with mild - to - moderate COVID - 19 pneumonia , severe acute respiratory syndrome coronavirus 2 infection confirmed by real - time RT - PCR , requiring at least 3 L / min of oxyg... |
Title : Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019 : open label , randomised controlled trial . METHODS : Multicentre , open label , randomised controlled trial . 16 government designated covid - 19 treatment centres in China , 11 to 29 February 2020 . 150 patients admitted to ... | {
"P": [
"patients with mainly mild to moderate coronavirus disease 2019",
"150 patients admitted to hospital with laboratory confirmed covid - 19"
],
"I": [
"Hydroxychloroquine",
"hydroxychloroquine",
"standard of care",
"one dose of hydroxychloroquine"
],
"C": [
"standard of care... |
Title : A two - arm , randomized , controlled , multi - centric , open - label phase - 2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID - 19 OBJECTTIVE : Efficacy and safety of Itolizumab , an immunomodulatory mAb , in treating moderate - to - severe acute respi... | {
"P": [
"moderate to severe ARDS patients due to COVID - 19"
],
"I": [
"Itolizumab",
"best supportive care [ BSC ]"
],
"C": [
"BSC"
],
"O": [
"mortality"
]
} |
Title : Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID - 19 : The REMAP - CAP COVID - 19 Corticosteroid Domain Randomized Clinical Trial . METHODS : An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains , for example , antiviral agen... | {
"P": [
"Patients With Severe COVID - 19",
"614 adult patients with suspected or confirmed COVID - 19"
],
"I": [
"Hydrocortisone",
"a fixed 7 - day course of intravenous hydrocortisone",
"a shock - dependent course"
],
"C": [
"no hydrocortisone"
],
"O": [
"organ support - free... |
Title : Effect of Helmet Noninvasive Ventilation vs High - Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID - 19 and Moderate to Severe Hypoxemic Respiratory Failure : The HENIVOT Randomized Clinical Trial . METHODS : Multicenter randomized clinical trial in 4 intensive care units ( ICUs ) i... | {
"P": [
"Patients With COVID - 19 and Moderate to Severe Hypoxemic Respiratory Failure",
"109 patients with COVID - 19 and moderate to severe hypoxemic respiratory failure ( ratio of partial pressure of arterial oxygen to fraction of inspired oxygen ?200 )"
],
"I": [
"Helmet Noninvasive Ventilation",... |
Title : Randomized clinical trial " olfactory dysfunction after COVID - 19 : olfactory rehabilitation therapy vs . intervention treatment with Palmitoylethanolamide and Luteolin " : preliminary results . METHODS : We conducted a randomized - controlled pilot study in outpatients with history of confirmed COVID - 19 wit... | {
"P": [
"outpatients with history of confirmed COVID - 19 with post - infection olfactory impairment that persisted ? 90 days after SARS - CoV - 2 negative testing"
],
"I": [
"Palmitoylethanolamide",
"Luteolin",
"weekly olfactory rehabilitation",
"daily oral supplement with PEA"
],
"C": [... |
Title : Tocilizumab combined with favipiravir in the treatment of COVID - 19 : A multicenter trial in a small sample size . METHODS : This was a multicenter trial in adults with COVID - 19 . Patients were randomly assigned ( 3:1:1 ) to a 14 - day combination of favipiravir combined with tocilizumab ( combination group ... | {
"P": [
"adults with COVID - 19"
],
"I": [
"Tocilizumab",
"favipiravir",
"a 14 - day combination of favipiravir",
"tocilizumab"
],
"C": [],
"O": [
"the cumulative lung lesion remission rate",
"lung CT examination indicated absorption of lung inflammation"
]
} |
Title : Discontinuation versus continuation of renin - angiotensin - system inhibitors in COVID - 19 ( ACEI - COVID ) : a prospective , parallel group , randomised , controlled , open - label trial . METHODS : ACEI - COVID was a parallel group , randomised , controlled , open - label trial done at 35 centres in Austria... | {
"P": [
"Patients aged 18 years and older"
],
"I": [
"Discontinuation",
"continuation of renin - angiotensin - system inhibitors",
"discontinuation",
"continuation of RAS inhibition"
],
"C": [],
"O": [
"the maximum sequential organ failure assessment ( SOFA ) score",
"area under... |
Title : [ Effect of Xuebijing injection on inflammatory markers and disease outcome of coronavirus disease 2019 ] . METHODS : Sixty severe COVID - 19 patients admitted to Changsha Public Health Treatment Center ( North Hospital of the First Hospital of Changsha City ) from January to March in 2020 were randomly divided... | {
"P": [
"Sixty severe COVID - 19 patients admitted to Changsha Public Health Treatment Center ( North Hospital of the First Hospital of Changsha City ) from January to March in 2020"
],
"I": [
"Xuebijing injection",
"Xuebijing"
],
"C": [
"routine treatment"
],
"O": [
"The blood routin... |
Title : Ruxolitinib in treatment of severe coronavirus disease 2019 ( COVID - 19 ) : A multicenter , single - blind , randomized controlled trial . METHODS : We conducted a prospective , multicenter , single - blind , randomized controlled phase II trial involving patients with severe coronavirus disease 2019 . | {
"P": [
"patients with severe coronavirus disease 2019"
],
"I": [
"Ruxolitinib"
],
"C": [],
"O": []
} |
Title : Dexamethasone vs methylprednisolone high dose for Covid - 19 pneumonia . METHODS : Ambispective cohort study with survival analysis of 216 patients diagnosed with severe Covid - 19 pneumonia confirmed by polymerase chain reaction for SARS - CoV2 by Berlin protocol , who were hospitalized in a high - complexity ... | {
"P": [
"216 patients diagnosed with severe Covid - 19 pneumonia confirmed by polymerase chain reaction for SARS - CoV2 by Berlin protocol , who were hospitalized in a high - complexity clinic in Medelln , Colombia"
],
"I": [
"Dexamethasone",
"methylprednisolone",
"intravenous dexamethasone",
... |
Title : Triple combination of interferon beta - 1 b , lopinavir - ritonavir , and ribavirin in the treatment of patients admitted to hospital with COVID - 19 : an open - label , randomised , phase 2 trial . METHODS : This was a multicentre , prospective , open - label , randomised , phase 2 trial in adults with COVID -... | {
"P": [
"patients admitted to hospital with COVID - 19",
"adults with COVID - 19 who were admitted to six hospitals in Hong Kong"
],
"I": [
"interferon beta - 1 b",
"lopinavir",
"ritonavir",
"ribavirin",
"a 14 - day combination of lopinavir",
"three doses of 8 million internationa... |
Title : Effect of Intermediate - Dose vs Standard - Dose Prophylactic Anticoagulation on Thrombotic Events , Extracorporeal Membrane Oxygenation Treatment , or Mortality Among Patients With COVID - 19 Admitted to the Intensive Care Unit : The INSPIRATION Randomized Clinical Trial . METHODS : Multicenter randomized tria... | {
"P": [
"Patients With COVID - 19 Admitted to the Intensive Care Unit",
"adult patients admitted to the ICU with COVID - 19"
],
"I": [
"Intermediate - Dose",
"intermediate - dose",
"statin therapy",
"Intermediate - dose ( enoxaparin"
],
"C": [
"Standard - Dose Prophylactic Anticoa... |
Title : Early Use of Corticosteroid May Prolong SARS - CoV - 2 Shedding in Non - Intensive Care Unit Patients with COVID - 19 Pneumonia : A Multicenter , Single - Blind , Randomized Control Trial . METHODS : This was a prospective , multicenter , single - blind , randomized control trial . Adult patients with COVID - 1... | {
"P": [
"Non - Intensive Care Unit Patients with COVID - 19 Pneumonia",
"Adult patients with COVID - 19 pneumonia who were admitted to the general ward"
],
"I": [
"Corticosteroid",
"methylprednisolone"
],
"C": [
"not"
],
"O": [
"the incidence of clinical deterioration"
]
} |
Title : [ Observation of therapeutic effect on coronavirus disease 2019 with insomnia in treatment with baduanjin and auricular point sticking therapy ] . METHODS : A total of 90 patients with COVID - 19 accompanied with insomnia were randomly divided into an observation group ( 45 cases , 3 cases dropped off ) and a c... | {
"P": [
"A total of 90 patients with COVID - 19 accompanied with insomnia"
],
"I": [
"baduanjin",
"auricular point sticking therapy",
"a traditional Chinese fitness activity"
],
"C": [
"estazolam"
],
"O": [
"the score of Pittsburgh sleep quality index ( PSQI )",
"the score of ... |
Title : Sarilumab in patients admitted to hospital with severe or critical COVID - 19 : a randomised , double - blind , placebo - controlled , phase 3 trial . METHODS : We did a 60 - day , randomised , double - blind , placebo - controlled , multinational phase 3 trial at 45 hospitals in Argentina , Brazil , Canada , C... | {
"P": [
"patients admitted to hospital with severe or critical COVID - 19",
"adults ( ?18 years ) admitted to hospital with laboratory - confirmed SARS - CoV - 2 infection and pneumonia , who required oxygen supplementation or intensive care"
],
"I": [
"Sarilumab",
"intravenous sarilumab",
"s... |
Title : The CABI Trial : an Unblinded Parallel Group Randomised Controlled Feasibility Trial of Long - Course Antibiotic Therapy ( 28 Days ) Compared with Short Course ( ? 10 Days ) in the Prevention of Relapse in Adults Treated for Complicated Intra - Abdominal Infection . METHODS : A randomised controlled unblinded f... | {
"P": [
"Adults Treated for Complicated Intra - Abdominal Infection",
"adult patients with a cIAI that were diagnosed ? 6 days prior to screening"
],
"I": [
"Long - Course Antibiotic Therapy",
"Short Course",
"long - course",
"short - course ( ?10 days ) antibiotic therapy"
],
"C": []... |
Title : Inhaled budesonide for COVID - 19 in people at high risk of complications in the community in the UK ( PRINCIPLE ) : a randomised , controlled , open - label , adaptive platform trial . METHODS : PRINCIPLE is a multicentre , open - label , multi - arm , randomised , controlled , adaptive platform trial done rem... | {
"P": [
"COVID - 19 in people at high risk of complications in the community in the UK",
"aged 65 years or older or 50 years or older with comorbidities , and unwell for up to 14 days with suspected COVID - 19 but not admitted to hospital"
],
"I": [
"Inhaled budesonide",
"usual care",
"inhale... |
Title : Sofosbuvir and daclatasvir compared with standard of care in the treatment of patients admitted to hospital with moderate or severe coronavirus infection ( COVID - 19 ) : a randomized controlled trial . METHODS : This was an open - label , multicentre , randomized controlled clinical trial in adults with modera... | {
"P": [
"patients admitted to hospital with moderate or severe coronavirus infection ( COVID - 19 )",
"adults with moderate or severe COVID - 19 admitted to four university hospitals in Iran"
],
"I": [
"Sofosbuvir",
"daclatasvir",
"sofosbuvir",
"standard care"
],
"C": [
"standard ... |
Title : [ Effect of moxibustion on clinical symptoms , peripheral inflammatory indexes and T lymphocyte subsets in COVID - 19 patients ] . METHODS : A total of 95 patients with COVID - 19 were randomly divided into a moxibustion group ( 45 cases ) and a basic treatment group ( 50 cases ) . The routine treatment of west... | {
"P": [
"COVID - 19 patients",
"A total of 95 patients with COVID - 19"
],
"I": [
"moxibustion",
"a moxibustion",
"the moxibustion"
],
"C": [],
"O": [
"clinical symptom scores for cough",
"asthmatic breathing",
"chest oppression",
"short breath",
"their remission rat... |
Title : Peginterferon lambda for the treatment of outpatients with COVID - 19 : a phase 2 , placebo - controlled randomised trial . METHODS : In this double - blind , placebo - controlled trial , outpatients with laboratory - confirmed COVID - 19 were randomly assigned to a single subcutaneous injection of peginterfero... | {
"P": [
"outpatients with COVID - 19",
"outpatients with laboratory - confirmed COVID - 19"
],
"I": [
"Peginterferon lambda",
"peginterferon lambda"
],
"C": [
"placebo"
],
"O": [
"the proportion of patients who were negative for severe acute respiratory syndrome coronavirus 2 ( SA... |
Title : Randomised , controlled , open label , multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission , morbidity and mortality in adult patients with COVID - 19 . METHODS : A randomised , controlled , phase II , open label , multicentre trial . 200 subjects with sev... | {
"P": [
"adult patients with COVID - 19",
"200 subjects with severe COVID - 19 and at least two risk factors for mortality"
],
"I": [
"hyperbaric oxygen",
"HBO",
"best practice treatment"
],
"C": [
"only best practice treatment"
],
"O": [
"ICU admission",
"criteria for sel... |
Title : A randomized , open - label , adaptive , proof - of - concept clinical trial of modulation of host thromboinflammatory response in patients with COVID - 19 : the DAWn - Antico study . METHODS : In this adaptive , open - label multicenter randomized clinical trial , we compare low molecular weight heparins at 50... | {
"P": [
"patients with COVID - 19",
"intensive care ( ICU ) patients",
"hospitalized COVID - 19 patients"
],
"I": [
"low molecular weight heparins",
"aprotinin",
"standard thromboprophylaxis"
],
"C": [],
"O": [
"thrombotic markers ( D - dimer )",
"clinical status",
"the ... |
Title : Nano - curcumin therapy , a promising method in modulating inflammatory cytokines in COVID - 19 patients . METHODS : Forty COVID - 19 patients and 40 healthy controls were recruited and evaluated for inflammatory cytokine expression and secretion . Subsequently , COVID - 19 patients were divided into two groups... | {
"P": [
"COVID - 19 patients",
"Forty COVID - 19 patients and 40 healthy controls"
],
"I": [
"Nano - curcumin therapy",
"Nano - curcumin"
],
"C": [
"the placebo"
],
"O": [
"The mRNA expression",
"cytokine secretion levels of IL - 1?",
"IL - 6",
"TNF - ?",
"IL - 18"... |
Title : Efficacy of Brazilian green propolis ( EPP - AF ) as an adjunct treatment for hospitalized COVID - 19 patients : A randomized , controlled clinical trial . METHODS : In a randomized , controlled , open - label , single - center trial , hospitalized adult COVID - 19 patients were treated with a standardized gree... | {
"P": [
"hospitalized COVID - 19 patients",
"hospitalized adult COVID - 19 patients"
],
"I": [
"Brazilian green propolis",
"EPP - AF",
"a standardized green propolis extract",
"EPP - AF?",
"standard care",
"an oral dose of 400 mg",
"800 mg / day of green propolis",
"Standa... |
Title : Remdesivir in adults with severe COVID - 19 : a randomised , double - blind , placebo - controlled , multicentre trial . METHODS : We did a randomised , double - blind , placebo - controlled , multicentre trial at ten hospitals in Hubei , China . Eligible patients were adults ( aged ?18 years ) admitted to hosp... | {
"P": [
"adults with severe COVID - 19",
"adults ( aged ?18 years ) admitted to hospital with laboratory - confirmed SARS - CoV - 2 infection , with an interval from symptom onset to enrolment of 12 days or less , oxygen saturation of 94 % or less on room air or a ratio of arterial oxygen partial pressure to... |
Title : The use of oxygen hoods in patients failing on conventional high - flow oxygen delivery systems , the effects on oxygenation , mechanical ventilation and mortality rates in hypoxic patients with COVID - 19 . A Prospective Controlled Cohort Study . METHODS : DesignProspective Controlled Cohort Study . SettingSin... | {
"P": [
"patients failing on conventional high - flow oxygen delivery systems",
"hypoxic patients with COVID - 19",
"ParticipantsAll patients admitted with a diagnosis of COVID - 19"
],
"I": [
"oxygen hoods",
"exposureOxygen hoods",
"helmets"
],
"C": [
"conventional high - flow ox... |
Title : Febuxostat therapy in outpatients with suspected COVID - 19 : A clinical trial . METHODS : We conducted a clinical trial involving adult outpatients with the moderate respiratory illness following COVID - 19 infection . Patients were randomly assigned to receive either FBX or HCQ for 5 days . The measured varia... | {
"P": [
"outpatients with suspected COVID - 19",
"adult outpatients with the moderate respiratory illness following COVID - 19 infection"
],
"I": [
"Febuxostat therapy",
"FBX",
"HCQ"
],
"C": [],
"O": [
"needs to hospitalisation",
"clinical",
"laboratory data",
"fever",
... |
Title : Methylprednisolone or dexamethasone , which one is superior corticosteroid in the treatment of hospitalized COVID - 19 patients : a triple - blinded randomized controlled trial . METHODS : In this prospective triple - blinded randomized controlled trial , we enrolled 86 hospitalized COVID - 19 patients from Aug... | {
"P": [
"hospitalized COVID - 19 patients",
"86 hospitalized COVID - 19 patients from August to November 2020 , in Shiraz , Iran"
],
"I": [
"Methylprednisolone",
"methylprednisolone"
],
"C": [
"dexamethasone"
],
"O": [
"a 9 - point WHO ordinal scale"
]
} |
Title : [ Post - COVID - 19 asthenic syndrome ] . METHODS : The study included 129 patients with an average age of 49 . 88 . 9 years who had undergone COVID - 19 using a continuous sample method . Patients for the study were selected at the clinical bases of outpatient clinics in Samara ( Russia ) in July - August 2020... | {
"P": [
"129 patients with an average age of 49 . 88 . 9 years who had undergone COVID - 19 using a continuous sample method"
],
"I": [
"ethylmethylhydroxypyridine succinate",
"Neurox"
],
"C": [
"medical drugs ( MD )"
],
"O": [
"The dynamics of the general state",
"weakness",
... |
Title : Repurposed Antiviral Drugs for Covid - 19 - Interim WHO Solidarity Trial Results . METHODS : We randomly assigned inpatients with Covid - 19 equally between one of the trial drug regimens that was locally available and open control ( up to five options , four active and the local standard of care ) . The intent... | {
"P": [
"inpatients with Covid - 19"
],
"I": [
"four active"
],
"C": [
"the local standard of care"
],
"O": [
"in - hospital mortality",
"Rate ratios for death"
]
} |
Title : Effect of Oral Azithromycin vs Placebo on COVID - 19 Symptoms in Outpatients With SARS - CoV - 2 Infection : A Randomized Clinical Trial . METHODS : Randomized clinical trial of azithromycin vs matching placebo conducted from May 2020 through March 2021 . Outpatients from the US were enrolled remotely via inter... | {
"P": [
"Outpatients With SARS - CoV - 2 Infection",
"Outpatients from the US"
],
"I": [
"Oral Azithromycin",
"azithromycin",
"a single oral 1 . 2 - g dose of azithromycin"
],
"C": [
"Placebo",
"matching placebo"
],
"O": [
"absence of self - reported COVID - 19 symptoms",
... |
Title : Exploring an Integrative Therapy for Treating COVID - 19 : A Randomized Controlled Trial . METHODS : A putative ARDS - suppressing drug Keguan - 1 was first developed and then evaluated by a randomized , controlled two - arm trial . The two arms of the trial consist of a control therapy ( alpha interferon inhal... | {
"P": [
"newly diagnosed COVID - 19 patients"
],
"I": [
"A putative ARDS - suppressing drug Keguan - 1",
"Keguan - 1"
],
"C": [
"alpha interferon inhalation",
"lopinavir",
"ritonavir"
],
"O": [
"adverse events",
"time to fever resolution",
"ARDS development",
"lung... |
Title : Intravenous high - dose vitamin C for the treatment of severe COVID - 19 : study protocol for a multicentre randomised controlled trial . METHODS : The investigators designed a multicentre prospective randomised placebo - controlled trial that is planned to recruit 308 adults diagnosed with COVID - 19 and trans... | {
"P": [
"308 adults diagnosed with COVID - 19 and transferred into the intensive care unit"
],
"I": [
"Intravenous high - dose vitamin C",
"HIVC"
],
"C": [
"placebo"
],
"O": [
"ventilation - free days"
]
} |
Title : Lopinavir - ritonavir in patients admitted to hospital with COVID - 19 ( RECOVERY ) : a randomised , controlled , open - label , platform trial . METHODS : In this randomised , controlled , open - label , platform trial , a range of possible treatments was compared with usual care in patients admitted to hospit... | {
"P": [
"patients admitted to hospital with COVID - 19"
],
"I": [
"Lopinavir",
"ritonavir",
"usual standard of care",
"lopinavir",
"hydroxychloroquine",
"dexamethasone",
"azithromycin"
],
"C": [
"usual care",
"usual standard of care alone"
],
"O": [
"28 - day a... |
Title : Evaluating the effects of Intravenous Immunoglobulin ( IVIg ) on the management of severe COVID - 19 cases : A randomized controlled trial . METHODS : In this randomized controlled trial , 84 patients were included : 52 in the IVIg group and 32 in the control group . The intervention group received IVIg at a do... | {
"P": [
"84 patients"
],
"I": [
"Intravenous Immunoglobulin ( IVIg )",
"the IVIg",
"IVIg",
"hydroxychloroquine",
"lopinavir",
"ritonavir",
"supportive care"
],
"C": [],
"O": [
"The demographic data",
"mortality rate",
"the need for mechanical ventilation",
"l... |
Title : Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID - 19 patients : A randomized clinical trial . METHODS : In this double - blind , single - center study , we enrolled patients with positive PCR test and / or CT findings for COVID - 19 . The participants of each gr... | {
"P": [
"outpatients and hospitalized COVID - 19 patients",
"patients with positive PCR test and / or CT findings for COVID - 19"
],
"I": [
"Ammonium Chloride",
"standard of care",
"Diphenhydramine Compound",
"Diphenhydramine"
],
"C": [
"Diphenhydramine alone",
"standard of ca... |
Title : [ A pilot study of hydroxychloroquine in treatment of patients with moderate COVID - 19 ] . METHODS : We prospectively enrolled 30 treatment - nave patients with confirmed COVID - 19 after informed consent at Shanghai Public Health Clinical Center . The patients were randomized 1?1 to HCQ group and the control ... | {
"P": [
"patients with moderate COVID - 19",
"30 treatment - nave patients with confirmed COVID - 19 after informed consent at Shanghai Public Health Clinical Center"
],
"I": [
"hydroxychloroquine",
"HCQ",
"conventional treatments"
],
"C": [
"conventional treatment only"
],
"O": [... |
Title : Tofacitinib in Patients Hospitalized with Covid - 19 Pneumonia . METHODS : We randomly assigned , in a 1 : 1 ratio , hospitalized adults with Covid - 19 pneumonia to receive either tofacitinib at a dose of 10 mg or placebo twice daily for up to 14 days or until hospital discharge . The primary outcome was the o... | {
"P": [
"Patients Hospitalized with Covid - 19 Pneumonia",
"hospitalized adults with Covid - 19 pneumonia"
],
"I": [
"Tofacitinib",
"tofacitinib"
],
"C": [
"placebo"
],
"O": [
"the occurrence of death",
"respiratory failure",
"the use of an eight - level ordinal scale",
... |
Title : The Efficacy of Computerized Cognitive Behavioral Therapy for Depressive and Anxiety Symptoms in Patients With COVID - 19 : Randomized Controlled Trial . METHODS : We customized a cCBT program focused on improving depressive and anxiety symptoms among patients with COVID - 19 , and then , we assessed its effect... | {
"P": [
"Patients With COVID - 19",
"patients with COVID - 19",
"A total of 252 patients with COVID - 19 at five sites"
],
"I": [
"Computerized Cognitive Behavioral Therapy",
"a cCBT program",
"cCBT",
"treatment as usual ( TAU",
"The cCBT",
"TAU",
"the cCBT intervention pr... |
Title : A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid - 19 . METHODS : In this platform trial of therapeutic agents , we randomly assigned hospitalized patients who had Covid - 19 without end - organ failure in a 1 : 1 ratio to receive either LY - CoV555 or matching placebo . In addition , all... | {
"P": [
"Hospitalized Patients with Covid - 19",
"hospitalized patients who had Covid - 19 without end - organ failure"
],
"I": [
"LY - CoV555",
"the antiviral drug remdesivir",
"supplemental oxygen",
"glucocorticoids"
],
"C": [
"matching placebo",
"placebo"
],
"O": [
... |
Title : The effects of narrative exposure therapy on COVID - 19 patients with post - traumatic stress symptoms : A randomized controlled trial . METHODS : A total of 111 COVID - 19 patients near the discharge stage with positive screening results for posttraumatic stress symptoms ( PTSS ) were randomly assigned ( 1 : 1... | {
"P": [
"COVID - 19 patients with post - traumatic stress symptoms",
"A total of 111 COVID - 19 patients near the discharge stage with positive screening results for posttraumatic stress symptoms ( PTSS )"
],
"I": [
"narrative exposure therapy",
"NET",
"personalized psychological intervention... |
Title : Effect of Intermediate - Dose vs Standard - Dose Prophylactic Anticoagulation on Thrombotic Events , Extracorporeal Membrane Oxygenation Treatment , or Mortality Among Patients With COVID - 19 Admitted to the Intensive Care Unit : The INSPIRATION Randomized Clinical Trial . METHODS : Multicenter randomized tria... | {
"P": [
"Patients With COVID - 19 Admitted to the Intensive Care Unit",
"adult patients admitted to the ICU with COVID - 19"
],
"I": [
"Intermediate - Dose",
"intermediate - dose",
"statin therapy",
"Intermediate - dose ( enoxaparin"
],
"C": [
"Standard - Dose Prophylactic Anticoa... |
Title : Remdesivir for the Treatment of Covid - 19 - Final Report . METHODS : We conducted a double - blind , randomized , placebo - controlled trial of intravenous remdesivir in adults who were hospitalized with Covid - 19 and had evidence of lower respiratory tract infection . Patients were randomly assigned to recei... | {
"P": [
"adults who were hospitalized with Covid - 19 and had evidence of lower respiratory tract infection"
],
"I": [
"Remdesivir",
"intravenous remdesivir",
"remdesivir"
],
"C": [
"placebo"
],
"O": [
"the time to recovery",
"discharge from the hospital",
"hospitalization... |
Title : Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment ( PROTECT ) of Hydroxychloroquine , Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID - 19 infection who have no comorbidities like diabetes mellitus : A structured summary of a study protocol for a randomized ... | {
"P": [
"newly diagnosed patients with COVID - 19 infection who have no comorbidities like diabetes mellitus",
"newly diagnosed patients , either hospitalized or in self - isolation , without any comorbidities or with controlled chronic medical conditions like diabetes mellitus and hypertension"
],
"I": ... |
Title : Clinical , Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID - 19 . METHODS : This clinical trial included 114 patients diagnosed as mild COVID - 19 . Patients were divided randomly into two age and sex - matched grou... | {
"P": [
"114 patients diagnosed as mild COVID - 19"
],
"I": [
"Ivermectin Mucoadhesive Nanosuspension Nasal Spray",
"ivermectin nanosuspension nasal spray",
"the Egyptian protocol of treatment for mild COVID - 19"
],
"C": [
"the Egyptian protocol for mild COVID - 19 only"
],
"O": [
... |
Title : Efficacy of two siddha polyherbal decoctions , Nilavembu Kudineer and Kaba Sura Kudineer , along with standard allopathy treatment in the management of mild to moderate symptomatic COVID - 19 patients - a double - blind , placebo - controlled , clinical trial . METHODS : The study was a double - blind , placebo... | {
"P": [
"mild to moderate symptomatic COVID - 19 patients",
"Patients ( n=125 ) diagnosed with mild to moderate COVID - 19 symptoms"
],
"I": [
"two siddha polyherbal decoctions",
"Nilavembu Kudineer",
"Kaba Sura Kudineer",
"standard allopathy treatment",
"KSK",
"NVK"
],
"C": [... |
Title : Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID - 19 : A Randomized Clinical Trial . METHODS : Randomized , open - label trial of hospitalized patients with confirmed severe acute respiratory syndrome coronavirus 2 ( SARS - CoV - 2 ) infection and moderate COV... | {
"P": [
"Patients With Moderate COVID - 19",
"hospitalized patients with confirmed severe acute respiratory syndrome coronavirus 2 ( SARS - CoV - 2 ) infection and moderate COVID - 19 pneumonia ( pulmonary infiltrates and room - air oxygen saturation > 94 % ) enrolled from March 15 through April 18 , 2020 , ... |
Title : Azithromycin in patients admitted to hospital with COVID - 19 ( RECOVERY ) : a randomised , controlled , open - label , platform trial . METHODS : In this randomised , controlled , open - label , adaptive platform trial ( Randomised Evaluation of COVID - 19 Therapy [ RECOVERY ] ) , several possible treatments w... | {
"P": [
"patients admitted to hospital with COVID - 19",
"patients admitted to hospital with COVID - 19 in the UK"
],
"I": [
"Azithromycin",
"usual standard of care",
"azithromycin"
],
"C": [
"usual standard of care alone"
],
"O": [
"28 - day all - cause mortality"
]
} |
Title : Dexamethasone in Hospitalized Patients with Covid - 19 . METHODS : In this controlled , open - label trial comparing a range of possible treatments in patients who were hospitalized with Covid - 19 , we randomly assigned patients to receive oral or intravenous dexamethasone ( at a dose of 6 mg once daily ) for ... | {
"P": [
"Hospitalized Patients with Covid - 19",
"patients who were hospitalized with Covid - 19"
],
"I": [
"Dexamethasone",
"oral",
"intravenous dexamethasone"
],
"C": [
"usual care alone"
],
"O": [
"28 - day mortality"
]
} |
Title : Telemanagement of Home - Isolated COVID - 19 Patients Using Oxygen Therapy With Noninvasive Positive Pressure Ventilation and Physical Therapy Techniques : Randomized Clinical Trial . METHODS : In this single - blinded randomized clinical trial , 60 patients with stage 1 pneumonia caused by SARS - CoV - 2 infec... | {
"P": [
"Home - Isolated COVID - 19 Patients",
"60 patients with stage 1 pneumonia caused by SARS - CoV - 2 infection"
],
"I": [
"Oxygen Therapy",
"Noninvasive Positive Pressure Ventilation",
"Physical Therapy Techniques",
"oxygen therapy",
"bilevel positive airway pressure ( BiPAP ) ... |
Title : Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID - 19 : A Randomized Clinical Trial . METHODS : Double - blind , randomized trial conducted at a single site in Cali , Colombia . Potential study participants were identified by simple random sampling from the state ' s health de... | {
"P": [
"Adults With Mild COVID - 19",
"A total of 476 adult patients with mild disease and symptoms for 7 days or fewer ( at home or hospitalized )"
],
"I": [
"Ivermectin",
"ivermectin"
],
"C": [
"placebo"
],
"O": [
"time to resolution of symptoms",
"Solicited adverse events"... |
Title : The value of high - flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia . METHODS : The clinical data of 22 patients with severe COVID - 19 were collected . The heart rate ( HR ) , respiratory rate ( RR ) and oxygenation index ( PO2 / FiO2 ) at 0 , 6 , 24 and 72 hours after treatment were ... | {
"P": [
"22 patients with severe COVID - 19"
],
"I": [
"high - flow nasal cannula oxygen therapy",
"the HFNC oxygen therapy"
],
"C": [
"the conventional oxygen therapy ( COT )"
],
"O": [
"The heart rate ( HR )",
"respiratory rate ( RR )",
"oxygenation index",
"PO2",
"F... |
Title : Convalescent plasma in the management of moderate covid - 19 in adults in India : open label phase II multicentre randomised controlled trial ( PLACID Trial ) . METHODS : Open label , parallel arm , phase II , multicentre , randomised controlled trial . 39 public and private hospitals across India . 464 adults ... | {
"P": [
"adults in India",
"464 adults ( ?18 years ) admitted to hospital ( screened 22 April to 14 July 2020 ) with confirmed moderate covid - 19 ( partial pressure of oxygen in arterial blood / fraction of inspired oxygen ( PaO2 / FiO2 ) ratio between 200 mm Hg and 300 mm Hg or a respiratory rate of more t... |
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