Sequence To Structured Output Tasks
Collection
NER, Information Extraction • 3 items • Updated
input_text stringlengths 97 2.51k | output_text dict |
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Title : Psychosocial behaviour management programme for home - dwelling people with dementia : A cluster - randomized controlled trial . Little is known about the effectiveness of a psychosocial behaviour management programme on home - dwelling people with dementia . We developed a Behaviour Analytics & Support Enhance... | {
"P": [
"home - dwelling people with dementia",
"persons with dementia aged 65 years or older to receive home care in the BASE programme in August 2016"
],
"I": [
"Psychosocial behaviour management programme"
],
"C": [],
"O": [
"An online monitoring",
"assessment system",
"challengi... |
Title : Rationale and design for the study of rivaroxaban to reduce thrombotic events , hospitalization and death in outpatients with COVID - 19 : The PREVENT - HD study . METHODS : PREVENT - HD is a double - blind , placebo - controlled , pragmatic , event - driven phase 3 trial to evaluate the efficacy and safety of ... | {
"P": [
"outpatients with COVID - 19",
"symptomatic outpatients with laboratory - confirmed COVID - 19 at risk for thrombotic events , hospitalization , and death"
],
"I": [
"rivaroxaban"
],
"C": [
"placebo"
],
"O": [
"a composite of symptomatic venous thromboembolism",
"myocardia... |
Title : Long - Lasting Neuropsychological Effects of a Computerized Cognitive Training in Patients Affected by Early Stage Alzheimer ' s Disease : Are They Stable Over Time ? . METHODS : Eighty AD patients were randomized in two groups and underwent a computerized cognitive training , or a control intervention . | {
"P": [
"Patients Affected by Early Stage Alzheimer ' s Disease",
"Eighty AD patients"
],
"I": [
"a Computerized Cognitive Training",
"a computerized cognitive training"
],
"C": [],
"O": []
} |
Title : Risperidone in the treatment of psychosis of Alzheimer disease : results from a prospective clinical trial . METHODS : The authors conducted a randomized , eight - week , double - blind , placebo - controlled , multicenter trial involving nursing home residents diagnosed with AD and psychosis . Four hundred sev... | {
"P": [
"nursing home residents diagnosed with AD and psychosis",
"Four hundred seventy - three patients"
],
"I": [
"Risperidone",
"1 . 0 to 1 . 5 mg risperidone"
],
"C": [
"placebo"
],
"O": [
"the Behavioral pathology in Alzheimer ' s Disease ( BEHAVE - AD ) Psychosis subscale",
... |
Title : Key lessons learned from short - term treatment trials of cholinesterase inhibitors for amnestic MCI . METHODS : The study was a 24 - week placebo - controlled trial designed to evaluate the efficacy and safety of donepezil HCl ( donepezil ) in the treatment of cognitive impairment in subjects with MCI . Primar... | {
"P": [
"subjects with MCI"
],
"I": [
"cholinesterase inhibitors",
"donepezil HCl ( donepezil )"
],
"C": [],
"O": [
"the NYU Paragraphs Test",
"the ADCS Clinicians Global - Impression of Change"
]
} |
Title : A randomized , double - blind , placebo - controlled , 16 - week study of the H3 receptor antagonist , GSK239512 as a monotherapy in subjects with mild - to - moderate Alzheimer ' s disease . METHODS : In this 16 - week , double - blind , randomized , parallel group study , 196 currently untreated subjects with... | {
"P": [
"subjects with mild - to - moderate Alzheimer ' s disease",
"196 currently untreated subjects with mild - tomoderate AD ( Mini Mental State Examination [ MMSE ] 16 - 24 )"
],
"I": [
"the H3 receptor antagonist",
"GSK239512"
],
"C": [
"placebo"
],
"O": [
"Episodic Memory",
... |
Title : Evaluating the effects of Intravenous Immunoglobulin ( IVIg ) on the management of severe COVID - 19 cases : A randomized controlled trial . METHODS : In this randomized controlled trial , 84 patients were included : 52 in the IVIg group and 32 in the control group . The intervention group received IVIg at a do... | {
"P": [
"84 patients"
],
"I": [
"Intravenous Immunoglobulin ( IVIg )",
"the IVIg",
"IVIg",
"hydroxychloroquine",
"lopinavir",
"ritonavir",
"supportive care"
],
"C": [],
"O": [
"The demographic data",
"mortality rate",
"the need for mechanical ventilation",
"l... |
Title : Response of patients with Alzheimer disease to rivastigmine treatment is predicted by the rate of disease progression . METHODS : A 26 - week , open - label extension study following a 26 - week , double - blind , randomized , placebo - controlled trial . Outpatient research centers at 22 sites in the United St... | {
"P": [
"patients with Alzheimer disease",
"187 of 235 patients"
],
"I": [
"rivastigmine treatment",
"rivastigmine"
],
"C": [
"placebo treatment",
"Placebo treatment"
],
"O": [
"Alzheimer ' s Disease Assessment Scale - cognitive subscale ( ADAS - Cog )",
"Progressive Deter... |
Title : Clinical effects of Abeta immunization ( AN1792 ) in patients with AD in an interrupted trial . METHODS : This randomized , multicenter , placebo - controlled , double - blind trial of IM AN1792 225 microg plus the adjuvant QS - 21 50 microg ( 300 patients ) and saline ( 72 patients ) included patients aged 50 ... | {
"P": [
"patients with AD",
"patients aged 50 to 85 years with probable AD , Mini - Mental State Examination ( MMSE ) 15 to 26"
],
"I": [
"Abeta immunization ( AN1792 )",
"IM AN1792",
"the adjuvant QS - 21"
],
"C": [
"saline"
],
"O": [
"pilot efficacy",
"AD Assessment Scal... |
Title : A phase III randomized trial of gantenerumab in prodromal Alzheimer ' s disease . METHODS : In this randomized , double - blind , placebo - controlled phase III study , we investigated gantenerumab over 2 years . Patients were randomized to gantenerumab 105 mg or 225 mg or placebo every 4 weeks by subcutaneous ... | {
"P": [],
"I": [
"gantenerumab"
],
"C": [
"placebo"
],
"O": [
"Clinical Dementia Rating Sum of Boxes ( CDR - SB ) score",
"cerebrospinal fluid biomarkers",
"amyloid positron emission tomography"
]
} |
Title : The impact of sofosbuvir / daclatasvir or ribavirin in patients with severe COVID - 19 . METHODS : Patients with a positive nasopharyngeal swab for SARS - CoV - 2 on RT - PCR or bilateral multi - lobar ground - glass opacity on their chest CT and signs of severe COVID - 19 were included . Subjects were divided ... | {
"P": [
"patients with severe COVID - 19",
"Patients with a positive nasopharyngeal swab for SARS - CoV - 2 on RT - PCR or bilateral multi - lobar ground - glass opacity on their chest CT and signs of severe COVID - 19"
],
"I": [
"sofosbuvir",
"daclatasvir",
"ribavirin",
"the recommended ... |
Title : Rivastigmine transdermal patch and physical exercises for Alzheimer ' s disease : a randomized clinical trial . METHODS : A randomized , controlled , single - blinded trial was conducted in 40 patients with mild to moderate stages of AD . All patients were daily treated with rivastigmine transdermal patch at a ... | {
"P": [
"40 patients with mild to moderate stages of AD"
],
"I": [
"Rivastigmine transdermal patch",
"physical exercises",
"rivastigmine transdermal patch",
"The exercise program",
"aerobic",
"flexibility",
"strength",
"balance movements"
],
"C": [],
"O": [
"Quality ... |
Title : Effects of Physical Activity in Nursing Home Residents with Dementia : A Randomized Controlled Trial . METHODS : Eighty - seven nursing home residents with dementia were randomly assigned to 3 physical activity interventions : activities of daily living ( ADL ) training , multicomponent exercise training , or c... | {
"P": [
"Nursing Home Residents with Dementia",
"Eighty - seven nursing home residents with dementia"
],
"I": [
"Physical Activity",
"3 physical activity interventions",
"activities of daily living ( ADL ) training",
"multicomponent exercise training",
"combined multicomponent exercis... |
Title : Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID - 19 : a randomized controlled trial . METHODS : This randomized controlled trial was conducted in Alberta during the first wave of the COVID - 19 pandemic without direct contact with participants . Community - dwelling ind... | {
"P": [
"Community - dwelling individuals with confirmed SARS - CoV - 2 infection ( by reverse transcription polymerase chain reaction [ RT - PCR ] viral ribonucleic acid test ) within the previous 4 days , and symptom onset within the previous 12 days"
],
"I": [
"hydroxychloroquine",
"oral hydroxych... |
Title : Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID - 19 and elevated D - dimer concentration ( ACTION ) : an open - label , multicentre , randomised , controlled trial . METHODS : We did a pragmatic , open - label ( with blinded adjudication ) , multicentre , randomised... | {
"P": [
"patients admitted to hospital with COVID - 19 and elevated D - dimer concentration",
"Patients ( aged ?18 years ) hospitalised with COVID - 19 and elevated D - dimer concentration , and who had COVID - 19 symptoms for up to 14 days before randomisation"
],
"I": [
"Therapeutic",
"therapeu... |
Title : Spine Surgery under general anesthesia may not increase the risk of Alzheimer ' s disease . METHODS : We searched the Clinical Data Repository of the University of Virginia for patients receiving spine surgery from January 1 , 1992 to March 1 , 2004 . Patients with newly - diagnosed AD after the surgery but bef... | {
"P": [
"patients receiving spine surgery from January 1 , 1992 to March 1 , 2004",
"Patients with newly - diagnosed AD after the surgery but before March 1 , 2009 ( a minimal 5 - year follow - up time after the surgery )"
],
"I": [
"Spine Surgery",
"general anesthesia"
],
"C": [],
"O": []
... |
Title : Traditional Chinese medicine shenhuang granule in patients with severe / critical COVID - 19 : A randomized controlled multicenter trial . METHODS : This was an open - label , multicenter , randomized , controlled clinical trial . At 4 medical centers , a total of 111 severe / critical patients were randomly as... | {
"P": [
"patients with severe / critical COVID - 19",
"a total of 111 severe / critical patients"
],
"I": [
"Traditional Chinese medicine shenhuang granule",
"Shenhuang Granule",
"SHG",
"standard care"
],
"C": [
"standard care alone"
],
"O": []
} |
Title : Efficacy of galantamine in probable vascular dementia and Alzheimer ' s disease combined with cerebrovascular disease : a randomised trial . METHODS : Eligible patients were randomly assigned galantamine 24 mg / day ( n=396 ) or placebo ( n=196 ) in a multicentre , double - blind , 6 - month trial . Primary end... | {
"P": [],
"I": [
"galantamine"
],
"C": [
"placebo"
],
"O": [
"cognition",
"Alzheimer ' s disease assessment scale",
"cognitive subscale [ ADAS - cog ]",
"global functioning",
"clinician ' s interview - based impression of change",
"caregiver input [ CIBIC - plus ]",
"act... |
Title : Changes in Brain Volume with Bapineuzumab in Mild to Moderate Alzheimer ' s Disease . METHODS : Bapineuzumab dosages included 0 . 5 mg / kg in carriers and 0 . 5 or 1 . 0 mg / kg in noncarriers , every 13 weeks for 78 weeks . Volumetric outcomes included annualized brain , ventricular , and mean hippocampal bou... | {
"P": [],
"I": [
"Bapineuzumab"
],
"C": [],
"O": [
"annualized brain",
"ventricular",
"mean hippocampal boundary shift integrals",
"BBSI",
"VBSI",
"HBSI"
]
} |
Title : Repurposed Antiviral Drugs for Covid - 19 - Interim WHO Solidarity Trial Results . METHODS : We randomly assigned inpatients with Covid - 19 equally between one of the trial drug regimens that was locally available and open control ( up to five options , four active and the local standard of care ) . The intent... | {
"P": [
"inpatients with Covid - 19"
],
"I": [
"four active"
],
"C": [
"the local standard of care"
],
"O": [
"in - hospital mortality",
"Rate ratios for death"
]
} |
Title : Magnesium treatment on methylation changes of transmembrane serine protease 2 ( TMPRSS2 ) . METHODS : This study is nested within the Personalized Prevention of Colorectal Cancer Trial , a double - blind 2 O 2 factorial randomized controlled trial , which enrolled 250 participants from Vanderbilt University Med... | {
"P": [
"250 participants from Vanderbilt University Medical Center"
],
"I": [
"Magnesium treatment"
],
"C": [],
"O": []
} |
Title : Nutritional treatment of aged individuals with Alzheimer disease living at home with their spouses : study protocol for a randomized controlled trial . METHODS : AD patients and their spouses ( aged > 65 years ) living at home ( n = 202 , 102 AD patients ) were recruited using central AD registers in Finland . ... | {
"P": [
"aged individuals with Alzheimer disease living at home with their spouses",
"AD patients and their spouses ( aged > 65 years ) living at home ( n = 202 , 102 AD patients )"
],
"I": [
"Nutritional treatment",
"tailored nutritional care",
"vitamin D"
],
"C": [
"a written guide"... |
Title : Ivermectin to prevent hospitalizations in patients with COVID - 19 ( IVERCOR - COVID19 ) a randomized , double - blind , placebo - controlled trial . METHODS : A randomized , double - blind , placebo - controlled study was conducted in non - hospitalized individuals with COVID - 19 in Corrientes , Argentina . P... | {
"P": [
"patients with COVID - 19",
"non - hospitalized individuals with COVID - 19 in Corrientes , Argentina",
"Patients with SARS - CoV - 2 positive nasal swabs",
"501 patients between August 19 th 2020 and February 22 nd 2021"
],
"I": [
"Ivermectin",
"ivermectin"
],
"C": [
"pla... |
Title : Efficacy of Brazilian green propolis ( EPP - AF ) as an adjunct treatment for hospitalized COVID - 19 patients : A randomized , controlled clinical trial . METHODS : In a randomized , controlled , open - label , single - center trial , hospitalized adult COVID - 19 patients were treated with a standardized gree... | {
"P": [
"hospitalized COVID - 19 patients",
"hospitalized adult COVID - 19 patients"
],
"I": [
"Brazilian green propolis",
"EPP - AF",
"a standardized green propolis extract",
"EPP - AF?",
"standard care",
"an oral dose of 400 mg",
"800 mg / day of green propolis",
"Standa... |
Title : Effects of a non - focal plasticity protocol on apathy in moderate Alzheimer ' s disease : a randomized , double - blind , sham - controlled trial . METHODS : Forty patients were randomized to receive either active or sham - tDCS over the left dorsolateral prefrontal cortex ( DLPFC ) . Patients received six ses... | {
"P": [
"Forty patients"
],
"I": [
"a non - focal plasticity protocol",
"active"
],
"C": [
"sham - tDCS"
],
"O": [
"apathy",
"Global cognition",
"neuropsychiatric symptoms"
]
} |
Title : Effects of a 2 - Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid - 19 : A Randomized Clinical Trial . METHODS : A total of 69 reverse transcriptase polymerase chain reaction ( RT - PCR ) SARS - CoV - 2 positive adults who were hospitalized f... | {
"P": [
"Patients with Mild to Moderate Covid - 19",
"A total of 69 reverse transcriptase polymerase chain reaction ( RT - PCR ) SARS - CoV - 2 positive adults who were hospitalized for mild to moderate COVID - 19 disease"
],
"I": [
"a 2 - Week 5000 IU",
"once daily for 2 weeks either 5000 IU ora... |
Title : What about tocilizumab ? A retrospective study from a NYC Hospital during the COVID - 19 outbreak . METHODS : In this retrospective analysis of patients with COVID - 19 admitted between March 2 and April 14 , 2020 to a large academic medical center in New York City , we describe outcomes associated with tociliz... | {
"P": [
"patients with COVID - 19 admitted between March 2 and April 14 , 2020 to a large academic medical center in New York City"
],
"I": [
"tocilizumab",
"without methylprednisolone"
],
"C": [
"a propensity - matched"
],
"O": [
"a 7 - point ordinal scale of oxygenation",
"venti... |
Title : Effect of Early Treatment With Hydroxychloroquine or Lopinavir and Ritonavir on Risk of Hospitalization Among Patients With COVID - 19 : The TOGETHER Randomized Clinical Trial . METHODS : This randomized clinical trial was conducted in Brazil . Recently symptomatic adults diagnosed with respiratory symptoms fro... | {
"P": [
"Patients With COVID - 19",
"Recently symptomatic adults diagnosed with respiratory symptoms from SARS - CoV - 2 infection"
],
"I": [
"Early Treatment With Hydroxychloroquine",
"Lopinavir",
"Ritonavir",
"hydroxychloroquine",
"lopinavir",
"ritonavir"
],
"C": [
"plac... |
Title : Citalopram for the Treatment of Agitation in Alzheimer Dementia : Genetic Influences . METHODS : We utilized data from the Citalopram for Agitation in Alzheimer ' s Disease ( CitAD ) database . CitAD was a 9 - week randomized , double - blind , placebo - controlled multicenter clinical trial showing significant... | {
"P": [],
"I": [
"Citalopram",
"the Citalopram",
"citalopram"
],
"C": [],
"O": []
} |
Title : Efficacy and safety of Levamisole treatment in clinical presentations of non - hospitalized patients with COVID - 19 : a double - blind , randomized , controlled trial . METHODS : This prospective , double - blind , randomized controlled clinical trial was performed in adult patients with mild to moderate COVID... | {
"P": [
"non - hospitalized patients with COVID - 19",
"adult patients with mild to moderate COVID - 19 ( room - air oxygen saturation > 94 % ) from late April 2020 to mid - August 2020"
],
"I": [
"Levamisole treatment",
"a 3 - day course of Levamisole",
"routine standard of care"
],
"C":... |
Title : Methylprednisolone in adults hospitalized with COVID - 19 pneumonia : An open - label randomized trial ( GLUCOCOVID ) . METHODS : The study was a multicentric open - label trial of COVID - 19 patients who were aged ? 18 years , receiving oxygen without mechanical ventilation , and with evidence of systemic infl... | {
"P": [
"adults hospitalized with COVID - 19 pneumonia",
"COVID - 19 patients who were aged ? 18 years , receiving oxygen without mechanical ventilation , and with evidence of systemic inflammatory response"
],
"I": [
"Methylprednisolone",
"SOC",
"intravenous MP"
],
"C": [
"standard o... |
Title : Safety and tolerability of immune globulin intravenous ( human ) , 10 % solution in Japanese subjects with mild to moderate Alzheimer ' s disease . METHODS : Among the 16 subjects , 12 subjects were assigned to the IGIV group and 4 subjects to the placebo group . Subjects received a total of six infusions of ei... | {
"P": [
"Japanese subjects with mild to moderate Alzheimer ' s disease",
"the 16 subjects"
],
"I": [
"immune globulin intravenous ( human )",
"the IGIV",
"IGIV"
],
"C": [
"the placebo",
"placebo"
],
"O": []
} |
Title : Donepezil therapy in clinical practice : a randomized crossover study . METHODS : Two - center , randomized , placebo - controlled , double - masked crossover study . Memory disorders units at Massachusetts General and Brigham and Women ' s hospitals , Boston . Sixty individuals ( 30 men and 30 women ; mean + /... | {
"P": [
"Sixty individuals ( 30 men and 30 women ; mean + / - SD age , 75 . 0 + / - 9 . 5 years ) with probable Alzheimer disease and scores of 20 or less on the information - memory - concentration subscale of the Blessed Dementia Scale"
],
"I": [
"Donepezil therapy",
"donepezil hydrochloride therap... |
Title : [ Observation of therapeutic effect on coronavirus disease 2019 with insomnia in treatment with baduanjin and auricular point sticking therapy ] . METHODS : A total of 90 patients with COVID - 19 accompanied with insomnia were randomly divided into an observation group ( 45 cases , 3 cases dropped off ) and a c... | {
"P": [
"A total of 90 patients with COVID - 19 accompanied with insomnia"
],
"I": [
"baduanjin",
"auricular point sticking therapy",
"a traditional Chinese fitness activity"
],
"C": [
"estazolam"
],
"O": [
"the score of Pittsburgh sleep quality index ( PSQI )",
"the score of ... |
Title : A Phase II Safety and Efficacy Study on Prognosis of Moderate Pneumonia in Coronavirus Disease 2019 Patients With Regular Intravenous Immunoglobulin Therapy . METHODS : An open - label , multicenter , comparative , randomized study was conducted on COVID - 19 patients with moderate pneumonia . One hundred eligi... | {
"P": [
"Coronavirus Disease 2019 Patients",
"COVID - 19 patients with moderate pneumonia",
"One hundred eligible patients"
],
"I": [
"Regular Intravenous Immunoglobulin Therapy",
"IVIG",
"standard of care ( SOC )"
],
"C": [
"SOC"
],
"O": []
} |
Title : Tolerability and efficacy of memantine add - on therapy to rivastigmine transdermal patches in mild to moderate Alzheimer ' s disease : a multicenter , randomized , open - label , parallel - group study . METHODS : In this multicenter , randomized , open - label study , patients entered an 8 - week run - in per... | {
"P": [],
"I": [
"memantine add - on therapy",
"rivastigmine transdermal patches",
"16 weeks of memantine",
"rivastigmine patch",
"rivastigmine patch monotherapy"
],
"C": [],
"O": [
"the retention rate"
]
} |
Title : Tocilizumab in Hospitalized Patients with Severe Covid - 19 Pneumonia . METHODS : In this phase 3 trial , we randomly assigned patients who were hospitalized with severe Covid - 19 pneumonia in a 2 : 1 ratio receive a single intravenous infusion of tocilizumab ( at a dose of 8 mg per kilogram of body weight ) o... | {
"P": [
"Hospitalized Patients with Severe Covid - 19 Pneumonia",
"patients who were hospitalized with severe Covid - 19 pneumonia"
],
"I": [
"Tocilizumab",
"a single intravenous infusion of tocilizumab",
"a second dose of tocilizumab",
"one dose of tocilizumab"
],
"C": [
"placebo... |
Title : Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer ' s disease . Eptastigmine Study Group . METHODS : This was a double - blind , randomized , placebo - controlled , unbalanced parallel - group study . One - hundred and three patients ( 83 in the eptas... | {
"P": [
"patients with Alzheimer ' s disease",
"One - hundred and three patients"
],
"I": [
"eptastigmine",
"the eptastigmine",
"20 mg eptastigmine"
],
"C": [
"the placebo",
"placebo"
],
"O": [
"the Logical Memory Test",
"Semantic Word Fluency Test",
"Trail Making ... |
Title : Effects of Folic Acid and Vitamin B12 Supplementation on Cognitive Impairment and Inflammation in Patients with Alzheimer ' s Disease : A Randomized , Single - Blinded , Placebo - Controlled Trial . METHODS : This was a randomized , single - blind , placebo - controlled trial . Patients ( n=120 ) diagnosed clin... | {
"P": [
"Patients with Alzheimer ' s Disease",
"Patients ( n=120 ) diagnosed clinically as probable AD and in stable condition from Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases"
],
"I": [
"Folic Acid",
"Vitamin B12 Supplementation",
"folic acid",
"vitamin B12"
... |
Title : Taste - masked and affordable donepezil hydrochloride orally disintegrating tablet as promising solution for non - compliance in Alzheimer ' s disease patients . METHODS : The ODT was manufactured using simple wet - granulation method . Crospovidone XL - 10 was used as superdisintegrant and optimization was don... | {
"P": [
"Alzheimer ' s disease patients"
],
"I": [
"Taste - masked and affordable donepezil hydrochloride",
"The ODT",
"three grades of lactose monohydrate compound",
"Starlac",
"Flowlac",
"Tablettose"
],
"C": [],
"O": []
} |
Title : Respiratory rehabilitation in elderly patients with COVID - 19 : A randomized controlled study . METHODS : This paper reported the findings of an observational , prospective , quasi - experimental study , which totally recruited 72 participants , of which 36 patients underwent respiratory rehabilitation and the... | {
"P": [
"elderly patients with COVID - 19",
"72 participants"
],
"I": [
"Respiratory rehabilitation",
"respiratory rehabilitation"
],
"C": [
"any rehabilitation intervention"
],
"O": [
"pulmonary function tests",
"plethysmography",
"diffusing lung capacity for carbon monox... |
Title : Safety and efficacy of methylphenidate for apathy in Alzheimer ' s disease : a randomized , placebo - controlled trial . METHODS : Six - week , randomized , double - blind , placebo - controlled multicenter trial enrolling Alzheimer ' s disease participants ( NINCDS - ADRDA criteria ) with apathy assigned to me... | {
"P": [
"Alzheimer ' s disease participants ( NINCDS - ADRDA criteria ) with apathy"
],
"I": [
"methylphenidate"
],
"C": [
"placebo"
],
"O": [
"Apathy Evaluation Scale ( AES ) score",
"modified Alzheimer ' s Disease Cooperative Study - Clinical Global Impression of Change ( ADCS - CGI... |
Title : Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID - 19 : A Randomized Clinical Trial . METHODS : Double - blind , randomized trial conducted at a single site in Cali , Colombia . Potential study participants were identified by simple random sampling from the state ' s health de... | {
"P": [
"Adults With Mild COVID - 19",
"A total of 476 adult patients with mild disease and symptoms for 7 days or fewer ( at home or hospitalized )"
],
"I": [
"Ivermectin",
"ivermectin"
],
"C": [
"placebo"
],
"O": [
"time to resolution of symptoms",
"Solicited adverse events"... |
Title : A web - based psychoeducational program for informal caregivers of patients with Alzheimer ' s disease : a pilot randomized controlled trial . METHODS : We recruited and randomized offline 49 informal caregivers of a PWAD in a day care center in Paris , France . They either received the Web - based intervention... | {
"P": [
"informal caregivers of patients with Alzheimer ' s disease",
"49 informal caregivers of a PWAD in a day care center in Paris , France"
],
"I": [
"A web - based psychoeducational program",
"the Web - based intervention"
],
"C": [
"usual care",
"only usual care"
],
"O": [
... |
Title : Cognitive effects of treating obstructive sleep apnea in Alzheimer ' s disease : a randomized controlled study . METHODS : Randomized double - blind placebo - controlled trial . Participants were randomized to therapeutic CPAP for 6 weeks or placebo CPAP for 3 weeks followed by therapeutic CPAP for 3 weeks . Ge... | {
"P": [
"Fifty - two men and women with mild to moderate AD and OSA"
],
"I": [
"treating obstructive sleep apnea",
"therapeutic CPAP",
"CPAP"
],
"C": [
"placebo CPAP"
],
"O": [
"A complete neuropsychological test battery"
]
} |
Title : Effect of Helmet Noninvasive Ventilation vs High - Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID - 19 and Moderate to Severe Hypoxemic Respiratory Failure : The HENIVOT Randomized Clinical Trial . METHODS : Multicenter randomized clinical trial in 4 intensive care units ( ICUs ) i... | {
"P": [
"Patients With COVID - 19 and Moderate to Severe Hypoxemic Respiratory Failure",
"109 patients with COVID - 19 and moderate to severe hypoxemic respiratory failure ( ratio of partial pressure of arterial oxygen to fraction of inspired oxygen ?200 )"
],
"I": [
"Helmet Noninvasive Ventilation",... |
Title : Efficacy and Safety of Citalopram Compared to Atypical Antipsychotics on Agitation in Nursing Home Residents With Alzheimer Dementia . METHODS : Longitudinal , 6 - month study . Nursing home ( NH ) . 75 NH residents with AD and agitation , randomized to citalopram ( n = 25 ) , quetiapine ( n = 25 ) , or olanzap... | {
"P": [
"Nursing Home Residents With Alzheimer Dementia",
"75 NH residents with AD and agitation"
],
"I": [
"Citalopram",
"citalopram",
"quetiapine",
"olanzapine"
],
"C": [
"Atypical Antipsychotics"
],
"O": [
"Neuropsychiatric Inventory ( NPI ) agitation subscale score",
... |
Title : Pakistan Randomized and Observational Trial to Evaluate Coronavirus Treatment ( PROTECT ) of Hydroxychloroquine , Oseltamivir and Azithromycin to treat newly diagnosed patients with COVID - 19 infection who have no comorbidities like diabetes mellitus : A structured summary of a study protocol for a randomized ... | {
"P": [
"newly diagnosed patients with COVID - 19 infection who have no comorbidities like diabetes mellitus",
"newly diagnosed patients , either hospitalized or in self - isolation , without any comorbidities or with controlled chronic medical conditions like diabetes mellitus and hypertension"
],
"I": ... |
Title : Randomized , placebo - controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer ' s disease . METHODS : In this randomized , double - blind , placebo - controlled pilot study , 67 patients with mild to moderate Alzheimer ' s disease received 24 weeks of treatment wit... | {
"P": [
"67 patients with mild to moderate Alzheimer ' s disease"
],
"I": [
"donepezil"
],
"C": [
"placebo"
],
"O": [
"right",
"left",
"total hippocampal volumes",
"magnetic resonance imaging",
"brain concentrations of N - acetylaspartate",
"proton magnetic resonance s... |
Title : Cost - effectiveness of donepezil and memantine in moderate to severe Alzheimer ' s disease ( the DOMINO - AD trial ) . METHODS : Cost - effectiveness analysis was based on a 52 - week , multicentre , double - blind , placebo - controlled , factorial clinical trial . A total of 295 community - dwelling patients... | {
"P": [
"A total of 295 community - dwelling patients with moderate / severe Alzheimer ' s disease"
],
"I": [
"donepezil",
"memantine"
],
"C": [],
"O": []
} |
Title : Long - term safety and tolerability of atabecestat ( JNJ - 54861911 ) , an oral BACE1 inhibitor , in early Alzheimer ' s disease spectrum patients : a randomized , double - blind , placebo - controlled study and a two - period extension study . METHODS : In the placebo - controlled double - blind parent ALZ2002... | {
"P": [
"early Alzheimer ' s disease spectrum patients",
"participants aged 50 to 85 years"
],
"I": [
"atabecestat ( JNJ - 54861911 )",
"an oral BACE1 inhibitor",
"atabecestat"
],
"C": [
"placebo"
],
"O": [
"Safety",
"CSF biomarker levels",
"brain volume",
"cogniti... |
Title : Metal - protein attenuation with iodochlorhydroxyquin ( clioquinol ) targeting Abeta amyloid deposition and toxicity in Alzheimer disease : a pilot phase 2 clinical trial . METHODS : A pilot phase 2 clinical trial in patients with moderately severe Alzheimer disease . | {
"P": [
"patients with moderately severe Alzheimer disease"
],
"I": [
"iodochlorhydroxyquin ( clioquinol )"
],
"C": [],
"O": []
} |
Title : Randomised , controlled , open label , multicentre clinical trial to explore safety and efficacy of hyperbaric oxygen for preventing ICU admission , morbidity and mortality in adult patients with COVID - 19 . METHODS : A randomised , controlled , phase II , open label , multicentre trial . 200 subjects with sev... | {
"P": [
"adult patients with COVID - 19",
"200 subjects with severe COVID - 19 and at least two risk factors for mortality"
],
"I": [
"hyperbaric oxygen",
"HBO",
"best practice treatment"
],
"C": [
"only best practice treatment"
],
"O": [
"ICU admission",
"criteria for sel... |
Title : Effect of Hydroxychloroquine in Hospitalized Patients with Covid - 19 . METHODS : In this randomized , controlled , open - label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid - 19 , we randomly assigned 1561 patients to receive hydroxychloroquine and... | {
"P": [
"Hospitalized Patients with Covid - 19",
"patients hospitalized with Covid - 19"
],
"I": [
"Hydroxychloroquine",
"hydroxychloroquine"
],
"C": [
"usual care"
],
"O": [
"28 - day mortality"
]
} |
Title : Febuxostat therapy in outpatients with suspected COVID - 19 : A clinical trial . METHODS : We conducted a clinical trial involving adult outpatients with the moderate respiratory illness following COVID - 19 infection . Patients were randomly assigned to receive either FBX or HCQ for 5 days . The measured varia... | {
"P": [
"outpatients with suspected COVID - 19",
"adult outpatients with the moderate respiratory illness following COVID - 19 infection"
],
"I": [
"Febuxostat therapy",
"FBX",
"HCQ"
],
"C": [],
"O": [
"needs to hospitalisation",
"clinical",
"laboratory data",
"fever",
... |
Title : Dexamethasone vs methylprednisolone high dose for Covid - 19 pneumonia . METHODS : Ambispective cohort study with survival analysis of 216 patients diagnosed with severe Covid - 19 pneumonia confirmed by polymerase chain reaction for SARS - CoV2 by Berlin protocol , who were hospitalized in a high - complexity ... | {
"P": [
"216 patients diagnosed with severe Covid - 19 pneumonia confirmed by polymerase chain reaction for SARS - CoV2 by Berlin protocol , who were hospitalized in a high - complexity clinic in Medelln , Colombia"
],
"I": [
"Dexamethasone",
"methylprednisolone",
"intravenous dexamethasone",
... |
Title : A two - arm , randomized , controlled , multi - centric , open - label phase - 2 study to evaluate the efficacy and safety of Itolizumab in moderate to severe ARDS patients due to COVID - 19 OBJECTTIVE : Efficacy and safety of Itolizumab , an immunomodulatory mAb , in treating moderate - to - severe acute respi... | {
"P": [
"moderate to severe ARDS patients due to COVID - 19"
],
"I": [
"Itolizumab",
"best supportive care [ BSC ]"
],
"C": [
"BSC"
],
"O": [
"mortality"
]
} |
Title : A 1 - year controlled trial of acetyl - l - carnitine in early - onset AD . METHODS : A 1 - year , multicenter , double - blind , placebo - controlled , randomized trial was conducted . Subjects were 45 to 65 years old , with a diagnosis of probable AD according to National Institute of Neurological Communicati... | {
"P": [
"45 to 65 years old , with a diagnosis of probable AD according to National Institute of Neurological Communicative Disorders - Alzheimer ' s Disease and Related Disorders Association criteria and had a Mini - Mental State Examination ( MMSE ) score between 12 and 26"
],
"I": [
"acetyl - l - carn... |
Title : Lopinavir - ritonavir in patients admitted to hospital with COVID - 19 ( RECOVERY ) : a randomised , controlled , open - label , platform trial . METHODS : In this randomised , controlled , open - label , platform trial , a range of possible treatments was compared with usual care in patients admitted to hospit... | {
"P": [
"patients admitted to hospital with COVID - 19"
],
"I": [
"Lopinavir",
"ritonavir",
"usual standard of care",
"lopinavir",
"hydroxychloroquine",
"dexamethasone",
"azithromycin"
],
"C": [
"usual care",
"usual standard of care alone"
],
"O": [
"28 - day a... |
Title : R - and S - citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation . METHODS : Citalopram enantiomer exposures ( AUC ( 0 , 24 h ) ) derived from an established population pharmacokinetic analysis were utilized to explore the relationship between ( R ... | {
"P": [
"elders with dementia and agitation"
],
"I": [
"R -",
"S - citalopram",
"Citalopram",
"( R ) -",
"( S ) - citalopram"
],
"C": [],
"O": [
"Mini - Mental State Examination ( MMSE )",
"Neurobehavioural Rating Scale - Agitation Subscale ( NBRS - A )",
"modified Alzhe... |
Title : A Phase II study targeting amyloid - beta with 3 APS in mild - to - moderate Alzheimer disease . METHODS : We assessed the safety , tolerability , and pharmacokinetic / pharmacodynamic effect of 3 APS in a randomized , double - blind , placebo - controlled Phase II study in which 58 subjects with mild - to - mo... | {
"P": [
"58 subjects with mild - to - moderate AD"
],
"I": [
"3 APS"
],
"C": [
"placebo"
],
"O": [
"plasma",
"CSF 3 APS concentrations",
"CSF levels of Abeta ( Abeta ( 40 ) and Abeta ( 42 ) )",
"total tau",
"cognitive",
"Alzheimer ' s Disease Assessment Scale - cogniti... |
Title : Ruxolitinib in treatment of severe coronavirus disease 2019 ( COVID - 19 ) : A multicenter , single - blind , randomized controlled trial . METHODS : We conducted a prospective , multicenter , single - blind , randomized controlled phase II trial involving patients with severe coronavirus disease 2019 . | {
"P": [
"patients with severe coronavirus disease 2019"
],
"I": [
"Ruxolitinib"
],
"C": [],
"O": []
} |
Title : Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID - 19 - associated cytokine storm syndrome : results of the CHIC study . METHODS : From 1 April 2020 , patients with COVID - 19 - associated CSS , defined as rapid respiratory dete... | {
"P": [
"patients with COVID - 19 - associated cytokine storm syndrome",
"patients with COVID - 19 - associated CSS , defined as rapid respiratory deterioration plus at least two out of three biomarkers with important elevations ( C - reactive protein > 100 mg / L ; ferritin > 900 g / L ; D - dimer > 1500 g ... |
Title : Effect of anakinra versus usual care in adults in hospital with COVID - 19 and mild - to - moderate pneumonia ( CORIMUNO - ANA - 1 ) : a randomised controlled trial . METHODS : In this multicentre , open - label , Bayesian randomised clinical trial ( CORIMUNO - ANA - 1 ) , nested within the CORIMUNO - 19 cohort... | {
"P": [
"adults in hospital with COVID - 19 and mild - to - moderate pneumonia",
"patients from 16 University hospitals in France with mild - to - moderate COVID - 19 pneumonia , severe acute respiratory syndrome coronavirus 2 infection confirmed by real - time RT - PCR , requiring at least 3 L / min of oxyg... |
Title : Homemade valved holding chambers for children with airway hyperresponsiveness : A randomized crossover trial . METHODS : In a randomized , two - period , two - sequence crossover trial , we recruited 20 children , aged 6 - 15 years , who had a greater than 12 % increase in FEV1 after inhaled salbutamol . They w... | {
"P": [
"children with airway hyperresponsiveness",
"20 children , aged 6 - 15 years , who had a greater than 12 % increase in FEV1 after inhaled salbutamol"
],
"I": [
"Homemade valved holding chambers",
"our VHC",
"Aerochamber",
"the same VHCs",
"those VHCs"
],
"C": [],
"O": [
... |
Title : Poor Safety and Tolerability Hamper Reaching a Potentially Therapeutic Dose in the Use of Thalidomide for Alzheimer ' s Disease : Results from a Double - Blind , Placebo - Controlled Trial . METHODS : This was a 24 - week , randomized , double - blind , placebo - controlled , parallel group study with escalatin... | {
"P": [
"patients with mild to moderate AD"
],
"I": [
"Thalidomide",
"thalidomide"
],
"C": [],
"O": [
"tolerability",
"cognitive performance"
]
} |
Title : [ Correlation analysis on changes between cognitive ability and brain fMRI after acupoint thread embedding in Alzheimer ' s disease patients ] . METHODS : Twenty - six patients with mild to moderate AD were assigned to the tested group and the control group in pairing , 13 in each group . ATE was performed in p... | {
"P": [
"Alzheimer ' s disease patients",
"Twenty - six patients with mild to moderate AD"
],
"I": [
"acupoint thread embedding",
"ATE"
],
"C": [],
"O": [
"cognitive ability",
"fMRI",
"the scores of Mini - Mental State Examination ( MMSE )",
"Alzhemer ' s Disease Assessment ... |
Title : Peginterferon lambda for the treatment of outpatients with COVID - 19 : a phase 2 , placebo - controlled randomised trial . METHODS : In this double - blind , placebo - controlled trial , outpatients with laboratory - confirmed COVID - 19 were randomly assigned to a single subcutaneous injection of peginterfero... | {
"P": [
"outpatients with COVID - 19",
"outpatients with laboratory - confirmed COVID - 19"
],
"I": [
"Peginterferon lambda",
"peginterferon lambda"
],
"C": [
"placebo"
],
"O": [
"the proportion of patients who were negative for severe acute respiratory syndrome coronavirus 2 ( SA... |
Title : Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID - 19 patients : results from a randomised controlled clinical trial . METHODS : We conducted a single - blind , randomised controlled clinical trial involving severe hospitalised patients with confirmed COVID - 19 at the early pul... | {
"P": [
"hospitalised severe COVID - 19 patients",
"severe hospitalised patients with confirmed COVID - 19 at the early pulmonary phase of the illness in Iran"
],
"I": [
"Intravenous methylprednisolone pulse",
"standard care",
"methylprednisolone pulse"
],
"C": [
"standard care alone"... |
Title : Azithromycin in patients admitted to hospital with COVID - 19 ( RECOVERY ) : a randomised , controlled , open - label , platform trial . METHODS : In this randomised , controlled , open - label , adaptive platform trial ( Randomised Evaluation of COVID - 19 Therapy [ RECOVERY ] ) , several possible treatments w... | {
"P": [
"patients admitted to hospital with COVID - 19",
"patients admitted to hospital with COVID - 19 in the UK"
],
"I": [
"Azithromycin",
"usual standard of care",
"azithromycin"
],
"C": [
"usual standard of care alone"
],
"O": [
"28 - day all - cause mortality"
]
} |
Title : The effects on cognitive functions of a movement - based intervention in patients with Alzheimer ' s type dementia : a pilot study . METHODS : The sample consisted of 27 patients fulfilling the AD ICD - 10 diagnostic criteria . The patient sample was randomly divided into two groups : The Exercise Group receive... | {
"P": [
"patients with Alzheimer ' s type dementia",
"27 patients fulfilling the AD ICD - 10 diagnostic criteria"
],
"I": [
"a movement - based intervention",
"The Exercise",
"6 weeks movement training"
],
"C": [
"a standard care"
],
"O": [
"Cognitive functions",
"six comp... |
Title : Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID - 19 in Brazil ( COALITION II ) : a randomised clinical trial . METHODS : We did an open - label , randomised clinical trial at 57 centres in Brazil . We enrolled pa... | {
"P": [
"patients admitted to the hospital with severe COVID - 19 in Brazil",
"patients admitted to hospital with suspected or confirmed COVID - 19"
],
"I": [
"Azithromycin",
"standard of care",
"azithromycin",
"hydroxychloroquine"
],
"C": [
"standard of care alone",
"standard... |
Title : Add - on prolonged - release melatonin for cognitive function and sleep in mild to moderate Alzheimer ' s disease : a 6 - month , randomized , placebo - controlled , multicenter trial . METHODS : The effects of add - on prolonged - release melatonin ( PRM ) ( 2 mg ) to standard therapy on cognitive functioning ... | {
"P": [
"80 patients ( men [ 50 . 7 % ] , women [ 49 . 3 % ] , average age 75 . 3 years [ range , 52 - 85 years ] ) diagnosed with mild to moderate AD , with and without insomnia comorbidity , and receiving standard therapy ( acetylcholinesterase inhibitors with or without memantine )"
],
"I": [
"Add - o... |
Title : Antiaggressive effect of cyproterone versus haloperidol in Alzheimer ' s disease : a randomized double - blind pilot study . METHODS : The subjects were 27 elderly patients referred to the University Hospital of Guadalajara Psychogeriatric Clinic diagnosed with AD and associated aggressive behavior ( mean Staff... | {
"P": [
"27 elderly patients referred to the University Hospital of Guadalajara Psychogeriatric Clinic diagnosed with AD and associated aggressive behavior ( mean Staff Observation Aggression Scale [ SOAS ] score > or=2 )"
],
"I": [
"cyproterone",
"haloperidol"
],
"C": [],
"O": [
"the SOAS ... |
Title : Nature and Dimensions of Systemic Hyperinflammation and its Attenuation by Convalescent Plasma in Severe COVID - 19 . METHODS : First , to characterize key cytokines and their dynamics in this hyperinflammatory condition , we assessed abundance and correlative expression of a panel of 48 cytokines in patients p... | {
"P": [
"patients progressing to ARDS as compared to patients with mild disease"
],
"I": [
"Convalescent Plasma",
"convalescent plasma therapy ( CPT )",
"CPT"
],
"C": [],
"O": [
"systemic cytokine dynamics",
"the level of hypoxia experienced by the patients"
]
} |
Title : Effect of statins on Alzheimer ' s disease biomarkers in cerebrospinal fluid . METHODS : We measured levels of cerebrospinal fluid ( CSF ) AD biomarkers following 14 weeks of treatment with simvastatin ( a CNS permeant statin ; n=10 ) at 40 mg / day or pravastatin ( a CNS impermeant statin ; n=13 ) at 80 mg / d... | {
"P": [
"hypercholesterolemic subjects without dementia"
],
"I": [
"statins",
"simvastatin",
"a CNS permeant statin",
"pravastatin",
"a CNS impermeant statin"
],
"C": [],
"O": [
"levels of cerebrospinal fluid ( CSF ) AD biomarkers"
]
} |
Title : Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID - 19 : A Randomized Clinical Trial . METHODS : Randomized , open - label trial of hospitalized patients with confirmed severe acute respiratory syndrome coronavirus 2 ( SARS - CoV - 2 ) infection and moderate COV... | {
"P": [
"Patients With Moderate COVID - 19",
"hospitalized patients with confirmed severe acute respiratory syndrome coronavirus 2 ( SARS - CoV - 2 ) infection and moderate COVID - 19 pneumonia ( pulmonary infiltrates and room - air oxygen saturation > 94 % ) enrolled from March 15 through April 18 , 2020 , ... |
Title : The value of subtraction MRI in detection of amyloid - related imaging abnormalities with oedema or effusion in Alzheimer ' s patients : An interobserver study . METHODS : We included 75 AD patients receiving bapineuzumab treatment , including 29 ARIA - E cases . Five neuroradiologists rated their brain MRI - s... | {
"P": [
"75 AD patients receiving bapineuzumab treatment , including 29 ARIA - E cases"
],
"I": [
"subtraction MRI",
"with",
"without subtraction images"
],
"C": [],
"O": [
"The accuracy of evaluating the presence of ARIA - E",
"intraclass correlation coefficient ( ICC )",
"spec... |
Title : Donepezil treatment of patients with MCI : a 48 - week randomized , placebo - controlled trial . METHODS : In this multicenter , randomized , placebo - controlled trial , subjects with MCI entered a 3 - week placebo run - in period followed by 48 weeks of double - blind donepezil ( 5 mg / day for 6 weeks , then... | {
"P": [
"patients with MCI",
"subjects with MCI"
],
"I": [
"Donepezil treatment",
"48 weeks of double - blind donepezil"
],
"C": [
"placebo treatment"
],
"O": [
"the modified Alzheimer Disease Assessment Scale - cognitive subscale ( ADAS - Cog )",
"Clinical Dementia Rating Sca... |
Title : Effect of Hydrocortisone on 21 - Day Mortality or Respiratory Support Among Critically Ill Patients With COVID - 19 : A Randomized Clinical Trial . METHODS : Multicenter randomized double - blind sequential trial conducted in France , with interim analyses planned every 50 patients . Patients admitted to the in... | {
"P": [
"Critically Ill Patients With COVID - 19",
"Patients admitted to the intensive care unit ( ICU ) for COVID - 19 - related acute respiratory failure"
],
"I": [
"Hydrocortisone",
"low - dose hydrocortisone"
],
"C": [
"placebo"
],
"O": [
"treatment failure",
"death",
... |
Title : Dexamethasone in Hospitalized Patients with Covid - 19 . METHODS : In this controlled , open - label trial comparing a range of possible treatments in patients who were hospitalized with Covid - 19 , we randomly assigned patients to receive oral or intravenous dexamethasone ( at a dose of 6 mg once daily ) for ... | {
"P": [
"Hospitalized Patients with Covid - 19",
"patients who were hospitalized with Covid - 19"
],
"I": [
"Dexamethasone",
"oral",
"intravenous dexamethasone"
],
"C": [
"usual care alone"
],
"O": [
"28 - day mortality"
]
} |
Title : Effectiveness of donepezil in reducing clinical worsening in patients with mild - to - moderate alzheimer ' s disease . METHODS : Data from 906 patients ( 388 receiving placebo ; 518 receiving donepezil ) with mild - to - moderate AD [ Mini - Mental State Examination ( MMSE ) score 10 - 27 ] were pooled from 3 ... | {
"P": [
"patients with mild - to - moderate alzheimer ' s disease",
"906 patients ( 388 receiving placebo ; 518 receiving donepezil ) with mild - to - moderate AD [ Mini - Mental State Examination ( MMSE ) score 10 - 27 ]"
],
"I": [
"donepezil"
],
"C": [],
"O": [
"cognition",
"MMSE",
... |
Title : Effect of tacrine on language , praxis , and noncognitive behavioral problems in Alzheimer disease . METHODS : An exploratory analysis using last observation carried forward . The study population included a placebo group ( n = 181 ) and all patients randomized to treatment within 160 mg / d of tacrine hydrochl... | {
"P": [
"Male and female subjects , at least 50 years of age , with mild to moderate AD and detectable baseline deficits in discrete cognitive and noncognitive parameters"
],
"I": [
"tacrine",
"160 mg / d of tacrine hydrochloride",
"tacrine therapy"
],
"C": [
"a placebo"
],
"O": [
... |
Title : Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease : a randomized controlled trial . METHODS : A multicenter , randomized , double - blind , placebo - controlled trial enrolling patients with mild AD was conducted at 133 trial sites in the United S... | {
"P": [
"patients with mild Alzheimer disease",
"patients with mild AD"
],
"I": [
"tarenflurbil",
"Tarenflurbil"
],
"C": [
"placebo"
],
"O": [
"the subscale of the Alzheimer Disease Assessment Scale - Cognitive Subscale ( ADAS - Cog , 80 - point version )",
"Alzheimer Disease ... |
Title : [ A pilot study of hydroxychloroquine in treatment of patients with moderate COVID - 19 ] . METHODS : We prospectively enrolled 30 treatment - nave patients with confirmed COVID - 19 after informed consent at Shanghai Public Health Clinical Center . The patients were randomized 1?1 to HCQ group and the control ... | {
"P": [
"patients with moderate COVID - 19",
"30 treatment - nave patients with confirmed COVID - 19 after informed consent at Shanghai Public Health Clinical Center"
],
"I": [
"hydroxychloroquine",
"HCQ",
"conventional treatments"
],
"C": [
"conventional treatment only"
],
"O": [... |
Title : Evaluation of Ivermectin as a Potential Treatment for Mild to Moderate COVID - 19 : A Double - Blind Randomized Placebo Controlled Trial in Eastern India . METHODS : A double blind , parallel , randomised , placebo - controlled trial conducted among adult COVID - 19 patients with mild to moderate disease severi... | {
"P": [
"adult COVID - 19 patients with mild to moderate disease severity on admission in a COVID dedicated tertiary healthcare of eastern India"
],
"I": [
"Ivermectin",
"ivermectin"
],
"C": [
"placebo"
],
"O": []
} |
Title : Double - blind , Randomized , Placebo - controlled Trial With N - acetylcysteine for Treatment of Severe Acute Respiratory Syndrome Caused by Coronavirus Disease 2019 ( COVID - 19 ) . METHODS : This was a double - blind , randomized , placebo - controlled , single - center trial conducted at the Emergency Depar... | {
"P": [
"patients with COVID - 19",
"135 patients with severe COVID - 19 ( confirmed or suspected ) , with an oxyhemoglobin saturation < 94 % or respiratory rate > 24 breaths / minute"
],
"I": [
"N - acetylcysteine",
"NAC"
],
"C": [
"dextrose"
],
"O": [
"the need for mechanical ve... |
Title : Early use of nitazoxanide in mild COVID - 19 disease : randomised , placebo - controlled trial . METHODS : In a multicentre , randomised , double - blind , placebo - controlled trial , adult patients presenting up to 3 days after onset of coronavirus disease 2019 ( COVID - 19 ) symptoms ( dry cough , fever and ... | {
"P": [
"adult patients presenting up to 3 days after onset of coronavirus disease 2019 ( COVID - 19 ) symptoms ( dry cough , fever and / or fatigue )"
],
"I": [
"nitazoxanide"
],
"C": [
"placebo"
],
"O": [
"complete resolution of symptoms",
"viral load",
"laboratory tests",
"... |
Title : Auxora versus standard of care for the treatment of severe or critical COVID - 19 pneumonia : results from a randomized controlled trial . METHODS : A randomized , controlled , open - label study of Auxora was conducted in adults with severe or critical COVID - 19 pneumonia . Patients were randomized 2 : 1 to r... | {
"P": [
"adults with severe or critical COVID - 19 pneumonia"
],
"I": [
"Auxora",
"three doses of once - daily Auxora"
],
"C": [
"standard of care",
"standard of care ( SOC ) alone"
],
"O": [
"the safety",
"tolerability"
]
} |
Title : A randomized , crossover trial of high - carbohydrate foods in nursing home residents with Alzheimer ' s disease : associations among intervention response , body mass index , and behavioral and cognitive function . METHODS : Thirty - four nursing home residents with probable AD who ate independently participat... | {
"P": [
"nursing home residents with Alzheimer ' s disease",
"Thirty - four nursing home residents with probable AD who ate independently"
],
"I": [
"high - carbohydrate foods",
"meals high in carbohydrate"
],
"C": [
"traditional dinners"
],
"O": [
"weighed food intake",
"body... |
Title : Early Use of Corticosteroid May Prolong SARS - CoV - 2 Shedding in Non - Intensive Care Unit Patients with COVID - 19 Pneumonia : A Multicenter , Single - Blind , Randomized Control Trial . METHODS : This was a prospective , multicenter , single - blind , randomized control trial . Adult patients with COVID - 1... | {
"P": [
"Non - Intensive Care Unit Patients with COVID - 19 Pneumonia",
"Adult patients with COVID - 19 pneumonia who were admitted to the general ward"
],
"I": [
"Corticosteroid",
"methylprednisolone"
],
"C": [
"not"
],
"O": [
"the incidence of clinical deterioration"
]
} |
Title : Heat - processed ginseng enhances the cognitive function in patients with moderately severe Alzheimer ' s disease . METHODS : Forty patients with AD were randomized into one of three different dose groups or the control group as follows : 1 . 5 g / day ( n = 10 ) , 3 g / day ( n = 10 ) , and 4 . 5 g / day ( n =... | {
"P": [
"patients with moderately severe Alzheimer ' s disease",
"Forty patients with AD"
],
"I": [
"Heat - processed ginseng"
],
"C": [],
"O": [
"The Alzheimer ' s Disease Assessment Scale ( ADAS )",
"Mini - Mental State Examination ( MMSE )"
]
} |
Title : Hydroxychloroquine in mild - to - moderate coronavirus disease 2019 : a placebo - controlled double blind trial . METHODS : We conducted a multicentre randomized double - blind placebo - controlled trial evaluating hydroxychloroquine in COVID - 19 patients with at least one of the following risk factors for wor... | {
"P": [
"COVID - 19 patients with at least one of the following risk factors for worsening : need for supplemental oxygen , age ?75 years , age between 60 and 74 years and presence of at least one co - morbidity"
],
"I": [
"Hydroxychloroquine",
"hydroxychloroquine",
"800 mg hydroxychloroquine"
... |
Title : Nano - curcumin therapy , a promising method in modulating inflammatory cytokines in COVID - 19 patients . METHODS : Forty COVID - 19 patients and 40 healthy controls were recruited and evaluated for inflammatory cytokine expression and secretion . Subsequently , COVID - 19 patients were divided into two groups... | {
"P": [
"COVID - 19 patients",
"Forty COVID - 19 patients and 40 healthy controls"
],
"I": [
"Nano - curcumin therapy",
"Nano - curcumin"
],
"C": [
"the placebo"
],
"O": [
"The mRNA expression",
"cytokine secretion levels of IL - 1?",
"IL - 6",
"TNF - ?",
"IL - 18"... |
Title : A Cluster - Randomized Trial of Hydroxychloroquine for Prevention of Covid - 19 . METHODS : We conducted an open - label , cluster - randomized trial involving asymptomatic contacts of patients with polymerase - chain - reaction ( PCR ) - confirmed Covid - 19 in Catalonia , Spain . We randomly assigned clusters... | {
"P": [
"asymptomatic contacts of patients with polymerase - chain - reaction ( PCR ) - confirmed Covid - 19 in Catalonia , Spain"
],
"I": [
"Hydroxychloroquine",
"the hydroxychloroquine"
],
"C": [
"the usual - care"
],
"O": [
"PCR - confirmed , symptomatic Covid - 19",
"SARS - Co... |
Title : Tocilizumab combined with favipiravir in the treatment of COVID - 19 : A multicenter trial in a small sample size . METHODS : This was a multicenter trial in adults with COVID - 19 . Patients were randomly assigned ( 3:1:1 ) to a 14 - day combination of favipiravir combined with tocilizumab ( combination group ... | {
"P": [
"adults with COVID - 19"
],
"I": [
"Tocilizumab",
"favipiravir",
"a 14 - day combination of favipiravir",
"tocilizumab"
],
"C": [],
"O": [
"the cumulative lung lesion remission rate",
"lung CT examination indicated absorption of lung inflammation"
]
} |
Title : Efficacy of two siddha polyherbal decoctions , Nilavembu Kudineer and Kaba Sura Kudineer , along with standard allopathy treatment in the management of mild to moderate symptomatic COVID - 19 patients - a double - blind , placebo - controlled , clinical trial . METHODS : The study was a double - blind , placebo... | {
"P": [
"mild to moderate symptomatic COVID - 19 patients",
"Patients ( n=125 ) diagnosed with mild to moderate COVID - 19 symptoms"
],
"I": [
"two siddha polyherbal decoctions",
"Nilavembu Kudineer",
"Kaba Sura Kudineer",
"standard allopathy treatment",
"KSK",
"NVK"
],
"C": [... |
Title : Health and nutrition promotion program for patients with dementia ( NutriAlz ) : cluster randomized trial . METHODS : Cluster randomized multi - centre study with one - year follow - up . 11 Alzheimer outpatients and day care centres ( Barcelona , Spain ) . Nine hundred and forty six home - living Alzheimer pat... | {
"P": [
"patients with dementia",
"Nine hundred and forty six home - living Alzheimer patients with identified caregiver"
],
"I": [
"Health and nutrition promotion program",
"a teaching and training intervention on health and nutrition program"
],
"C": [],
"O": [
"the loss of autonomy",... |
Title : Clinical , Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID - 19 . METHODS : This clinical trial included 114 patients diagnosed as mild COVID - 19 . Patients were divided randomly into two age and sex - matched grou... | {
"P": [
"114 patients diagnosed as mild COVID - 19"
],
"I": [
"Ivermectin Mucoadhesive Nanosuspension Nasal Spray",
"ivermectin nanosuspension nasal spray",
"the Egyptian protocol of treatment for mild COVID - 19"
],
"C": [
"the Egyptian protocol for mild COVID - 19 only"
],
"O": [
... |
Title : Safety and efficacy of Favipiravir in moderate to severe SARS - CoV - 2 pneumonia . METHODS : We did a multicenter randomized open - labeled clinical trial on moderate to severe cases infections of SARS - CoV - 2 . Patients with typical ground glass appearance on chest computerized tomography scan ( CT scan ) a... | {
"P": [
"Patients with typical ground glass appearance on chest computerized tomography scan ( CT scan ) and oxygen saturation ( SpO2 ) of less than 93 %"
],
"I": [
"Favipiravir",
"Lopinavir",
"Ritonavir",
"standard care"
],
"C": [],
"O": [
"In - hospital mortality",
"ICU admiss... |
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