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Safety, pharmacokinetics and proof-of-mechanism of an oral bruton's tyrosine kinase inhibitor HM71224 in healthy adult volunteers
Abstract:
Background: HM71224 is an orally available, irreversible and highly selective small molecule inhibiting Bruton's Tyrosine Kinase (BTK) which plays key roles in B‐cell receptor (BC... | embase |
Periprocedural outcomes of prophylactic protamine administration for reversal of heparin after cryoballoon ablation of atrial fibrillation
Abstract:
Purpose: The aim of this study was to investigate the efficacy and the safety of prophylactic use of protamine in a series of heparinized patients having undergone cryoba... | embase |
A phase II randomized trial of lapatinib with either vinorelbine or capecitabine as first- and second-line therapy for HER2 overexpressing metastatic breast cancer (MBC)
Abstract:
Background: Lapatinib (L) is approved for the treatment of human epidermal growth factor receptor 2 (HER2) positive MBC in combination with... | embase |
Diagnostic value of serum adenosine deaminase levels in sputum smear negative pulmonary tuberculosis patients in Nepalese population
Abstract:
Objective: To assess the levels of adenosine deaminase (ADA) in serum in patients with sputum smear negative pulmonary tuberculosis (SNPTB) and to compare it with serum ADA lev... | embase |
Effectiveness of video-based home exercise for osteoarthritis of the knee: a randomized controlled trial
Abstract:
Purpose: Several systematic reviews conclude that exercise therapy has beneficial effects on pain and physical function of the population with osteoarthritis (OA) of the knee. However, its positive post‐t... | embase |
Evaluation of prednisolone and prednisolone sodium succinate concentrations in human plasma and inner ear perilymph during cochlear implantation 24 h after intratympanic injection
Abstract:
Background: The use of intratympanic (IT) steroids has drastically increased over the past 10–15 years to manage many otological ... | embase |
Real-world efficacy and safety of mycophenolate mofetil in active moderate-to-sight-threatening thyroid eye disease
Abstract:
Purpose: There is no universal consensus on second‐line agents for the treatment of moderate/severe to sight‐threatening thyroid eye disease (TED) to maintain remission after first‐line intrave... | embase |
Genetic aspects associated with the seed per pod trait in soybean
Abstract:
Numerical traits related to yield have different sensitivity to the environment, being the seed per pod (SPP) one of the most stable, providing an opportunity to increase it genetically if lines with high SPP were available. The SPP is a weigh... | embase |
Effect of 52 weeks of mirikizumab on inflammatory bowel disease questionnaire scores in patients with moderately to severely active crohn's disease
Abstract:
Introduction: Mirikizumab (miri; IL‐23p19 antibody) is a humanized, IgG4 monoclonal antibody specifically targeting the p19 subunit of IL23. Miri has demonstrate... | embase |
Brain responses to emotional stimuli after eicosapentaenoic acid and docosahexaenoic acid treatments in major depressive disorder: toward personalized medicine with anti-inflammatory nutraceuticals
Abstract:
N‐3 polyunsaturated fatty acid supplements improve the symptoms of major depressive disorder (MDD) in randomize... | embase |
Impacts of citrulline malate supplementation on the fatigue in multiple sclerosis
Abstract:
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of central nervous system and fatigue is one of the most common symptoms in multiple sclerosis.As a result, patient's daily affairs deteriorate obviously b... | embase |
Everolimus with reduced calcineurin inhibitor exposure in de novo kidney transplant recipients: infection and wound healing outcomes from the transform study
Abstract:
Background: Post‐transplant (Tx) infections affect graft and patient survival. The protective effect of early introduction of everolimus (EVR) against ... | embase |
Tolerability of inhaled N-chlorotaurine-a phase I clinical study
Abstract:
N‐chlorotaurine (NCT), an endogenous antiseptic applicable to different body regions was tested on its tolerability upon inhalation in humans. This was a double‐blind and randomized study with a parallel test (1% NCT) and control group (0.9% Na... | embase |
The teen bypass equipoise sleeve trial (teen-best): a randomised controlled trial of gastric bypass versus sleeve gastrectomy for adolescents with severe obesity dragons' den meets shark tank (proposals for randomized controlled trials)
Abstract:
Background and rationale for the RCT, including existing literature revi... | embase |
Late breaking abstract-is there a role for cardiopulmonary exercise testing in identifying COPD patients most likely to respond to morphine?
Abstract:
Introduction: Opioids are rarely prescribed for breathlessness in advanced COPD due, in part, to an inability to predict which patient (s) will respond. Objectives: To ... | embase |
Phase I/II randomized trial of GM.CD40L vaccine plus/minus CCL21 in advanced lung adenocarcinoma: final results
Abstract:
Background: Our GM.CD40L vaccine (an allogeneic tumor cell‐based vaccine generated from human bystander cell line) recruits and activates dendritic cells, which then migrate to regional lymph nodes... | embase |
The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes
Abstract:
Background: Lipid and glycemic abnormalities are prevalent in diabetes leading to long term complications. Use of safe and natural foods instead of medications is now considered by many scientist... | embase |
Mathematical Modeling of Free Thyroxine Concentrations During Methimazole Treatment for Graves’ Disease: development and Validation of a Computer-Aided Thyroid Treatment Method
Abstract:
Background: Methimazole (MMI) is the first‐line treatment for patients with Graves’ disease (GD). While there are empirical recommen... | embase |
EQUIP INTERIM RESULTS: a PHASE 1B STUDY EVALUATING ITOLIZUMAB IN SUBJECTS WITH MODERATE-TO-SEVERE UNCONTROLLED ASTHMA
Abstract:
Introduction: CD6 is a co‐stimulatory receptor predominantly expressed on T cells; its ligand, ALCAM, is expressed on antigen presenting, epithelial and endothelial cells. The CD6/ALCAM pathw... | embase |
Higher rates of paroxysmal atrial fibrillation in stroke of undetermined etiology after 12 months
Abstract:
Background And Aims: Detection of paroxysmal atrial fibrillation (pAF) results in oral anticoagulation for secondary stroke prevention. In a subgroup of stroke patients with unknown etiology, the ESUS‐concept (“... | embase |
Comparison of intraarticular bupivacaine-dexmedetomidine and bupivacaine-magnesium sulfate for postoperative analgesia in arthroscopic meniscectomy: a randomized controlled clinical trial
Abstract:
Background: Arthroscopic meniscus surgery can lead to pain at various levels. In this study, we aimed to compare, in pati... | embase |
Accuracy of wrist-worn heart rate monitors for chronotropic assessment in atrial fibrillation
Abstract:
Introduction: Wrist‐worn fitness and heart rate (HR) monitors are increasingly popular. Previous studies in healthy participants with sinus rhythm (SR) have yielded variable results depending on HR, activity levels ... | embase |
Effect of Intervention Nursing on Radiation Pneumonia Caused by Radiotherapy of Thoracic Tumor
Abstract:
Objective:To investigate the effect of nursing on radiation pneumonia caused by radiotherapy of thoracic tumors. Methods:One hundred patients with radiation pneumonia (≥ grade 2) caused by thoracic tumor radiothera... | embase |
Performance of two alternative treatments for cervical pre-cancer against standard gas-based cryotherapy
Abstract:
Objective: Gas‐based cryotherapy, the standard treatment for cervical pre‐cancer in low‐resource settings, is problematic due to the need for cryogenic gas. To develop alternative treatments, we compared ... | embase |
A propensity score analysis of two methods of hepatic vascular occlusion in hepatectomy
Abstract:
Background The key points in hepatectomy are reducing blood loss and preservation of hepatic function. The aim of this study was to compare the perioperative outcomes of partial hepatectomy using two techniques of hepatic... | embase |
Effect of enoxaparin sodium on the coagulation function of patients with nonsmall cell lung cancer
Abstract:
Objective: To investigate the effect of enoxaparin sodium on the coagulation function of patients with non‐small cell lung cancer. Methods: From Jan, 2014 to Jan, 2016, 100 patients with non‐small cell lung can... | embase |
Rapid viral response (RVR) as a predictor of treatment failure in hepatitis C virus (HCV) patients receiving ledipasvir and sofosbuvir (LDV/SOF): a retrospective case-control analysis
Abstract:
Background. New HCV therapies report cure rates of ∼90% but are costly. Rapid viral response, defined as undetectable viral l... | embase |
Comparison of short-term outcomes between two sacrospinous suture capture devices : a randomised controlled trial
Abstract:
Introduction: Sacrospinous Fixation is a procedure for mid‐compartment apical suspension in pelvic organ prolapse surgery with high success rates. The approach by traditional wide dissection has ... | embase |
The double-blind studyof isolated and combined use of tranexamic acid and epidural anesthesia in scoliosis surgery
Abstract:
Aims: To assess the effectiveness of tranexamic acid (TA) and in combination with epidural anesthesia (EA) on perioperative blood loss and hemostasis/fibrinolysis in scoliosis surgery. A prospec... | embase |
CGRP monoclonal antibody LY2951742 for the prevention of migraine: a Phase 2, Randomized, double-blind, placebo-controlled study
Abstract:
OBJECTIVE: We evaluated the efficacy and safety of LY2951742, a fully humanized monoclonal antibody to Calcitonin Gene Related Peptide for migraine prevention. BACKGROUND: Migraine... | embase |
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