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bionli-en-101 | NLI | BioNLI | Premise:
To study the time-course of influenza-induced asthma, we retrospectively examined FEV1 from five days before to ten days after the onset of illness in 20 asthmatic children aged 8 to 12 years with tolerable respiratory symptoms. Influenza infection was confirmed by a rise at least fourfold in serum complement ... | entailment |
bionli-en-102 | NLI | BioNLI | Premise:
We have shown that proteinase-activated receptor-2 (PAR(2)) activation in the airways leads to allergic sensitization to concomitantly inhaled Ags, thus implicating PAR(2) in the pathogenesis of asthma. Many aeroallergens with proteinase activity activate PAR(2). To study the role of PAR(2) in allergic sensiti... | contradiction |
bionli-en-103 | NLI | BioNLI | Premise:
Dry cough is the most common limiting factor of ACE inhibitor (ACEI) use. Generation of NO, a proinflammatory substance on bronchial epithelial cells, is increased by ACEI. Using a randomized, double-blind, placebo-controlled trial, we tested the hypothesis that supplementing iron, an inhibitor of NO synthase,... | entailment |
bionli-en-104 | NLI | BioNLI | Premise:
Acute respiratory syncytial virus (RSV)-induced bronchiolitis is often associated with continuing respiratory symptoms following hospitalization. To date, there is no validated objective measure to evaluate symptoms of RSV-induced bronchiolitis. We report on the reliability, validity, and responsiveness of the... | entailment |
bionli-en-105 | NLI | BioNLI | Premise:
Airway wall remodeling is an established pathological feature in asthma. Its causes are not well understood, but one mediator of potential relevance is transforming growth factor-beta 1 (TGF-beta 1). We have measured levels of immunoreactive TGF-beta 1 in bronchoalveolar lavage (BAL) fluid from clinically stab... | contradiction |
bionli-en-106 | NLI | BioNLI | Premise:
We have previously shown in sheep that pulmonary vascular resistance decreases rapidly after the onset of constant exercise, followed by a slower and smaller second vasodilation. The second phase is partly regulated by alpha- and beta-adrenoceptor activation. We examined the effect of inhaled nitric oxide (NO;... | contradiction |
bionli-en-107 | NLI | BioNLI | Premise:
The sites of action of endogenous and inhaled nitric oxide (NO) were reassured during hypoxic pulmonary vasoconstriction. Lungs of 21 adult cats were perfused in situ with autologous blood in zone-3 conditions. Capillary pressures were measured by the double-occlusion techniques and pressures in arterioles and... | entailment |
bionli-en-108 | NLI | BioNLI | Premise:
In Western countries heart disease is the leading cause of maternal death during pregnancy. The effect of pregnancy on the heart is difficult to study in patients with preexisting heart disease. Since experimental studies are scarce, we investigated the effect of pressure overload, produced by transverse aorti... | contradiction |
bionli-en-109 | NLI | BioNLI | Premise:
Although endogenous nitric oxide (NO) modulates basal tone in the fetal pulmonary and systemic circulations, little is known about its role in regulating ductus arteriosus (DA) tone. Immunostaining of DA tissue from late-gestation fetal lambs demonstrated strong staining for endothelial NO synthase (eNOS) in D... | entailment |
bionli-en-110 | NLI | BioNLI | Premise:
In the pulmonary artery isolated from 1-week hypoxia-induced pulmonary hypertensive rats, endothelial NO production stimulated by carbachol was decreased significantly in in situ visualization using diaminofluorescein-2 diacetate and also in cGMP content. This change was followed by the decrease in carbachol-i... | entailment |
bionli-en-111 | NLI | BioNLI | Premise:
Tobramycin, an aminoglycoside antibiotic, is used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Tobramycin bioactivity, however, is antagonized by sputum. Glycoproteins (mucins) and high-molecular-weight DNA make up 2 to 3% (P. L. Masson and J. F. Heremans, p. 412-475, In M... | entailment |
bionli-en-112 | NLI | BioNLI | Premise:
Pneumocystis carinii pneumonia (PCP) continues to cause significant morbidity in recipients of solid-organ transplants. While some programs administer trimethoprim-sulfamethoxazole (TMP-SMX) prophylactically following transplantation, a prospective determination of the safety and efficacy of TMP-SMX in cardiac... | entailment |
bionli-en-113 | NLI | BioNLI | Premise:
Mycophenolate mofetil [MMF, the prodrug of mycophenolic acid (MPA)] is usually administered at double doses with cyclosporine than with tacrolimus because it is believed that MPA exposure is lower during cyclosporine therapy. This study aimed to compare 12 hour, steady-state concentration-time profiles of MPA ... | contradiction |
bionli-en-114 | NLI | BioNLI | Premise:
CMV is a frequently occurring pathogen in recipients of solid organ transplants, and those receiving lung transplants seem to be affected more frequently and more severely. Because the duration of prophylactic ganciclovir may influence the incidence of CMV disease in solid organ transplant recipients, we evalu... | entailment |
bionli-en-115 | NLI | BioNLI | Premise:
The inflammatory response following initiation of antibiotic therapy and parameters of neuronal damage were compared during intravenous treatment with quinupristin/dalfopristin (100 mg/kg as either a short or a continuous infusion) and ceftriaxone (10 mg/kg/h) in a rabbit model of Streptococcus pneumoniae meni... | contradiction |
bionli-en-116 | NLI | BioNLI | Premise:
Constitutive STAT3 activation by tyrosine phosphorylation of mutated or amplified tyrosine kinases (pYSTAT3) is critical for cancer initiation, progression, invasion, and motility of carcinoma cells. We showed that AF1q is associated with STAT3 signaling in breast cancer cells. In xenograft models, enhanced AF... | entailment |
bionli-en-117 | NLI | BioNLI | Premise:
Estrogen receptor-α (ER-α), encoded by ESR1, is detected by immunohistochemistry in approximately 70% of invasive breast cancers and serves as a strong predictive biomarker. ESR1-activating mutations in the ligand-binding domain have been reported in up to 35-40% of ER-positive metastatic breast cancers and ar... | entailment |
bionli-en-118 | NLI | BioNLI | Premise:
Esophageal cancer (EC) is an aggressive disease, presenting two main histological subtypes: adenocarcinoma (EAC) and squamous cell carcinoma (ESCC). The two EC subtypes widely differ concerning virtually all factors. ESCC development is mainly associated with tobacco and alcohol abuse, whereas obesity and chro... | contradiction |
bionli-en-119 | NLI | BioNLI | Premise:
The progression of prostate cancer to metastatic and castration-resistant disease represents a critical step. We previously showed that protein kinase C (PKC) activation followed by Twist1 and androgen receptor (AR) induction played a critical role in castration resistance, but the precise molecular mechanism ... | contradiction |
bionli-en-120 | NLI | BioNLI | Premise:
Cancer cells prefer glycolysis for energy metabolism, even when there is sufficient oxygen to make it unnecessary. This is called the Warburg effect, and it promotes tumorigenesis and malignant progression. In this study, we demonstrated that EZH2, a multifaceted oncogenic protein involved in tumor proliferati... | contradiction |
bionli-en-121 | NLI | BioNLI | Premise:
Intramitochondrial Sr2+, similar to Ca2+, inhibits oxidative phosphorylation in intact rat-liver mitochondria. Both Ca2+ and Sr2+ also inhibit the hydrolytic activity of the ATPase in submitochondrial particles. Half-maximal inhibition of ATPase activity was attained at a concentration of 2.5 mM Ca2+ or 5.0 mM... | entailment |
bionli-en-122 | NLI | BioNLI | Premise:
Mitochondrial calcium is an important modulator of cellular metabolism. CCDC90A was reported to be a regulator of the mitochondrial calcium uniporter (MCU) complex, a selective channel that controls mitochondrial calcium uptake, and hence was renamed MCUR1. Here we show that suppression of CCDC90A in human fib... | entailment |
bionli-en-123 | NLI | BioNLI | Premise:
Mitochondria produce the bulk of the ATP in most cells, including brain cells. Regulating this complex machinery to match the energetic needs of the cell is a complicated process that we have yet to understand in its entirety. In this context, 3',5'-cyclic AMP (cAMP) has been suggested to play a seminal role i... | contradiction |
bionli-en-124 | NLI | BioNLI | Premise:
ADP is not only a key substrate for ATP generation, but also a potent inhibitor of mitochondrial permeability transition pore (mPTP). In this study, we assessed how oxidative stress affects the potency of ADP as an mPTP inhibitor and whether its reduction of reactive oxygen species (ROS) production might be in... | entailment |
bionli-en-125 | NLI | BioNLI | Premise:
Previous researchers have demonstrated that 3,4-methylenedioxymethamphetamine (MDMA) induced hyperthermia, in skeletal muscle of animals, is uncoupling protein 3 (UCP3) dependent. In light of our investigations that in vivo phosphorylation of UCP1 is augmented under conditions of cold-acclimation, we set out t... | contradiction |
bionli-en-126 | NLI | BioNLI | Premise:
CsrA (carbon storage regulator A) is a widely distributed bacterial RNA binding protein that regulates translation initiation and mRNA stability of target transcripts. In γ-proteobacteria, CsrA activity is competitively antagonized by one or more small RNAs (sRNAs) containing multiple CsrA binding sites, but C... | contradiction |
bionli-en-127 | NLI | BioNLI | Premise:
The global transcriptional regulator Spx of Bacillus subtilis is controlled at several levels of the gene expression process. It is maintained at low concentrations during unperturbed growth by the ATP-dependent protease ClpXP. Under disulfide stress, Spx concentration increases due in part to a reduction in C... | contradiction |
bionli-en-128 | NLI | BioNLI | Premise:
Exoprotease production in Bacillus subtilis is positively regulated by a two-component regulatory system, DegS-DegU, and, in addition, by several minor factors. The product of the degR gene belongs to the latter group and exerts a positive effect in a DegS-DegU dependent manner. We found that transcription of ... | entailment |
bionli-en-129 | NLI | BioNLI | Premise:
Population density-dependent expression of luminescence in Vibrio fischeri is controlled by the autoinducer N-3-oxohexanoyl-L-homoserine lactone (autoinducer 1 [AI-1]), which via LuxR activates transcription of the lux operon (luxICDABEG, encoding the putative autoinducer synthase [LuxI] and the luminescence e... | contradiction |
bionli-en-130 | NLI | BioNLI | Premise:
Mycobacterium smegmatis, a rapidly growing non-pathogenic mycobacterium, is currently used as a model organism to study mycobacterial genetics. Acetamidase of M. smegmatis is the highly inducible enzyme of Mycobacteria, which utilizes several amide compounds as sole carbon and nitrogen sources. The acetamidase... | entailment |
bionli-en-131 | NLI | BioNLI | Premise:
It has been suggested that the tissue inhibitor of metalloproteinases-1 (TIMP-1) is involved in spontaneous resolution of liver fibrosis. The aim of this study was to investigate whether TIMP-1 altered spontaneous resolution of liver fibrosis in conjunction with matrix metalloproteinases (MMP) inhibition and h... | contradiction |
bionli-en-132 | NLI | BioNLI | Premise:
Liver fibrosis, which is the pathophysiologic process of the liver due to sustained wound healing in response to chronic liver injury, will eventually progress to cirrhosis. Puerarin, a bioactive isoflavone glucoside derived from the traditional Chinese medicine pueraria, has been reported to have many anti-in... | entailment |
bionli-en-133 | NLI | BioNLI | Premise:
Polyenylphosphatidylcholine (PPC), a polyunsaturated phospholipid extract from soy beans, prevents the development of liver cirrhosis in animal models. Its mechanism of action is unknown. Based on the hypothesis that PPC might act by decreasing hepatic stellate cell proliferation, we studied the effect of PPC ... | entailment |
bionli-en-134 | NLI | BioNLI | Premise:
The activated hepatic stellate cell (HSC) is central to liver fibrosis as the major source of collagens I and III and the tissue inhibitors of metalloproteinase-1 (TIMP-1). During spontaneous recovery from liver fibrosis, there is a decrease of TIMP expression, an increase in collagenase activity, and increase... | contradiction |
bionli-en-135 | NLI | BioNLI | Premise:
Activation of hepatic stellate cells (HSCs) plays a pivotal role in the development of liver fibrosis. C1q/tumor necrosis factor-related protein 3 (CTRP3), a member of CTRPs, was involved in fibrosis. However, little is known about the role of CTRP3 in liver fibrosis. This study aimed to determine its role in ... | entailment |
bionli-en-136 | NLI | BioNLI | Premise:
The need for improved specificity in the local treatment of inflammatory bowel diseases (IBD) led us to use negatively charged liposomes to target the inflamed colonic epithelium. The purpose of the present study was to elucidate the cause for our previous observations that such liposomes accumulate, preferent... | entailment |
bionli-en-137 | NLI | BioNLI | Premise:
Curcumin (diferulolylmethane) demonstrates profound anti-inflammatory effects in intestinal epithelial cells (IEC) and in immune cells in vitro and exhibits a protective role in rodent models of chemically induced colitis, with its presumed primary mechanism of action via inhibition of NF-kappaB. Although it h... | contradiction |
bionli-en-138 | NLI | BioNLI | Premise:
Obesity is a risk factor for developing inflammatory bowel disease. Pea is unique with its high content of dietary fiber, polyphenolics, and glycoproteins, all of which are known to be health beneficial. We aimed to investigate the impact of green pea (GP) supplementation on the susceptibility of high-fat diet... | entailment |
bionli-en-139 | NLI | BioNLI | Premise:
Bilirubin is thought to exert anti-inflammatory effects by inhibiting vascular cell adhesion molecule-1 (VCAM-1)-dependent leukocyte migration and by suppressing the expression of inducible nitric oxide synthase (iNOS). As VCAM-1 and iNOS are important mediators of tissue injury in the dextran sodium sulfate (... | entailment |
bionli-en-140 | NLI | BioNLI | Premise:
The incidence of inflammatory bowel diseases has increased during recent decades. Within the colon, the families of mucins (MUC) and trefoil factors (TFF) facilitate mucosal protection. Probiotic administration influences the intestinal MUC layer. Additionally, food components may affect gut microflora or have... | contradiction |
bionli-en-141 | NLI | BioNLI | Premise:
Hypoxia inducible factor 1α (HIF1α) is a master regulator leading to metabolic adaptation, an essential physiological process to maintain the survival of stem cells under hypoxia. However, it is poorly understood how HIF1α translocates into the nucleus in stem cells under hypoxia. Here, we investigated the rol... | contradiction |
bionli-en-142 | NLI | BioNLI | Premise:
Von Hippel-Lindau protein (pVHL) normally functions to cause ubiquitin-mediated degradation of hypoxia-inducible factor-1alpha (HIF-1alpha) under normoxic but not under hypoxic conditions, and induces neuronal differentiation of neural progenitor cells. However, the role of pVHL in the differentiation of neura... | contradiction |
bionli-en-143 | NLI | BioNLI | Premise:
The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen deprivation. However, the degree and duration of HIF-1α expression in hypoxia must be carefully balanced within cells in order to avoid unwanted side effec... | contradiction |
bionli-en-144 | NLI | BioNLI | Premise:
The expression of the core autophagy kinase, Unc51-like kinase 1 (ULK1), is regulated transcriptionally and translationally by starvation-induced autophagy. However, how ULK1 is regulated during hypoxia is not well understood. Previously, we showed that ULK1 expression is induced by hypoxia stress. Here, we re... | contradiction |
bionli-en-145 | NLI | BioNLI | Premise:
Hypoxic conditions are suggested to affect the differentiation status of stem cells (SC), including embryonic stem cells (ESC). Hypoxia inducible factor (HIF) is one of the main intracellular molecules responsible for the cellular response to hypoxia. Hypoxia stabilizes HIF by inhibiting the activity of HIF pr... | contradiction |
bionli-en-146 | NLI | BioNLI | Premise:
The BTK inhibitor ibrutinib has demonstrated a remarkable therapeutic effect in mantle cell lymphoma (MCL). However, approximately one-third of patients do not respond to the drug initially. To identify the mechanisms underlying primary ibrutinib resistance in MCL, we analyzed the transcriptome changes in ibru... | entailment |
bionli-en-147 | NLI | BioNLI | Premise:
Activation-induced cytidine deaminase (AID) is required for somatic hypermutation and immunoglobulin (Ig) class switch recombination in germinal center (GC) B cells. Occasionally, AID can target non-Ig genes and thereby promote GC B-cell lymphomagenesis. We recently showed that the oncogenic BCR-ABL1 kinase in... | contradiction |
bionli-en-148 | NLI | BioNLI | Premise:
Activating mutations of c-Kit are frequently found in acute myeloid leukemia (AML) patients harboring t(8;21) chromosomal translocation generating a fusion protein AML1-ETO. Here we show that an active mutant of c-Kit cooperates with AML1-ETO to induce AML in mouse bone marrow transplantation models. Leukemic ... | entailment |
bionli-en-149 | NLI | BioNLI | Premise:
To study the oncogenic role of the NRAS oncogene (NRAS(G12V)) in the context of acute myeloid leukemia (AML), we used a Vav promoter-tetracycline transactivator (Vav-tTA)-driven repressible TRE-NRAS(G12V) transgene system in Mll-AF9 knock-in mice developing AML. Conditional repression of NRAS(G12V) expression ... | entailment |
bionli-en-150 | NLI | BioNLI | Premise:
Internal tandem duplication (ITD) in the juxtamembrane portion of Fms-like tyrosine kinase 3 (FLT3), a type III receptor tyrosine kinase (RTK), is the most common molecular defect associated with acute myeloid leukemia (AML). The high prevalence of this activating mutation makes it a potential target for molec... | entailment |
liveqa-en-001 | QA | LiveQA | Literature on Cardiac amyloidosis. Please let me know where I can get literature on Cardiac amyloidosis. My uncle died yesterday from this disorder. Since this is such a rare disorder, and to honor his memory, I would like to distribute literature at his funeral service. I am a retired NIH employee, so I am familia... | Cardiac amyloidosis is a disorder caused by deposits of an abnormal protein (amyloid) in the heart tissue. These deposits make it hard for the heart to work properly. |
liveqa-en-002 | QA | LiveQA | Literature on Cardiac amyloidosis. Please let me know where I can get literature on Cardiac amyloidosis. My uncle died yesterday from this disorder. Since this is such a rare disorder, and to honor his memory, I would like to distribute literature at his funeral service. I am a retired NIH employee, so I am familia... | The term "amyloidosis" refers not to a single disease but to a collection of diseases in which a protein-based infiltrate deposits in tissues as beta-pleated sheets. The subtype of the disease is determined by which protein is depositing; although dozens of subtypes have been described, most are incredibly rare or of t... |
liveqa-en-003 | QA | LiveQA | Migraine seems to be a spectrum of conditions rather than only one easily diagnosed affliction. Many innovative migraine treatments are now in use, but it seems that each treatment only addresses a narrow set of conditions; for example, my daughter has tried many different treatment options (QEEG, HEG, TMS, topamax, .... | There is no absolute cure for migraine since its pathophysiology has yet to be fully understood. There are two ways to approach the treatment of migraine headache with drugs: prevent the attacks, or relieve the symptoms during the attacks. Prevention involves the use of medications and behavioral changes. Drugs origina... |
liveqa-en-004 | QA | LiveQA | When and how do you know when you have congenital night blindness? | X-linked congenital stationary night blindness is a disorder of the retina, which is the specialized tissue at the back of the eye that detects light and color. People with this condition typically have difficulty seeing in low light (night blindness). They also have other vision problems, including loss of sharpness (... |
liveqa-en-005 | QA | LiveQA | Gene changes or chromosomal changes of MSUD? What is the technical and simple language of MSUD? Are there any treatments for MSUD? | Mutations in the BCKDHA, BCKDHB, and DBT genes can cause maple syrup urine disease. These three genes provide instructions for making proteins that work together as a complex. The protein complex is essential for breaking down the amino acids leucine, isoleucine, and valine, which are present in many kinds of food, par... |
liveqa-en-006 | QA | LiveQA | I was born with Diabetes Insipidus and have many problems since the cell was removed when I was 22 and ALL | Diabetes insipidus is an uncommon condition in which the kidneys are unable to prevent the excretion of water. |
liveqa-en-007 | QA | LiveQA | I may have a couple anal fissures and looking to speak with someone to get some information and support. | An anal fissure is a small split or tear in the thin moist tissue (mucosa) lining the lower rectum (anus). |
liveqa-en-008 | QA | LiveQA | Are there any researches indicating how early an individual may experience any signs or symptoms of Rheumatoid Arthritis? | Swelling and Pain in the Joints Different types of arthritis have different symptoms. In general, people with most forms of arthritis have pain and stiffness in their joints. Rheumatoid arthritis is characterized by inflammation of the joint lining. This inflammation causes warmth, redness, swelling, and pain around th... |
liveqa-en-009 | QA | LiveQA | Are there any researches indicating how early an individual may experience any signs or symptoms of Rheumatoid Arthritis? | Rheumatoid arthritis is characterized by inflammation of the joint lining. This inflammation causes warmth, redness, swelling, and pain around the joints. The pain of rheumatoid arthritis varies greatly from person to person, for reasons that doctors do not yet understand completely. Factors that contribute to the pain... |
liveqa-en-010 | QA | LiveQA | article defining 'conversion disorder' In your article defining 'conversion disorder', [http://www.nlm.nih.gov/medlineplus/ency/article/000954.htm] , the quote "Conversion disorder is a mental health condition in which a person has blindness paralysis, or other nervous system (neurologic) symptoms that cannot be explai... | Diagnostic testing does not find any physical cause for the symptoms. The doctor will do a physical exam and may order diagnostic tests. These are to make sure there are no physical causes for the symptom. |
liveqa-en-011 | QA | LiveQA | I have been battling Anal fissure for close to two years now and it has refused to heal all these while. Please what do you suggest i do? Thanks | Most fissures heal on their own and do not need treatment. To prevent or treat anal fissures in infants, be sure to change diapers often and clean the area gently.CHILDREN AND ADULTSWorrying about pain during a bowel movement may cause a person to avoid them. But not having bowel movements will only cause the stools to... |
liveqa-en-012 | QA | LiveQA | My daughter has menkes syndrome and would like to know how to go about. Thx | These resources address the diagnosis or management of Menkes syndrome: - Gene Review: Gene Review: ATP7A-Related Copper Transport Disorders - Genetic Testing Registry: Menkes kinky-hair syndrome - MedlinePlus Encyclopedia: Copper in diet - MedlinePlus Encyclopedia: Menkes syndrome These resources from MedlinePlus offe... |
liveqa-en-013 | QA | LiveQA | NO HEALTH CARE ON MY SON SUFFERING FROM GENDER DYSPHORIA WHAT CAN WE DO TO HELP HIM HE WORKED OUT OF HIGH SCHOOL NO PROBLEMS NOW NOT WORKING AND SHUTTING HIMSELF IN HIS ROOM 24/7 THERES NOTHING ABOUT THIS CONDITION IN OUR AREA WE LIVE IN [LOCATION]. NO HELP IN AREA WHAT CAN WE DO HE HAS HAD BAD THOUGHTS ALREADY PLEASE ... | Individual and family therapy is recommended for children to create a supportive environment at home and in school. Individual and, if appropriate, couples therapy is recommended for adults. Sex reassignment through surgery and hormonal therapy is an option. But identity problems may continue after this treatment. |
liveqa-en-014 | QA | LiveQA | My mother recently died from Bowel Ischemia and Septic Shock. My question is this, she was in the ER for 12 hours before she was even seen by the general surgeon and then he wasn't convinced that it was this condition yet. He said that he'd check on her in the morning once she was finally put into an ICU room (this w... | Septic shock has a high death rate. The death rate depends on the patient's age and overall health, the cause of the infection, how many organs have failed, and how quickly and aggressively medical therapy is started. |
liveqa-en-015 | QA | LiveQA | my husband was diagnosed with Rocky Mountain Spotted fever about 6 1/2 years ago. Then about 1 1/2 years ago he was diagnosed with Lyme Disease. With him having had both what damage if any to his body could possibly happen. He has had alot of medical problems since. Now has been diagnosed with type II diabetes. | If diagnosed in the early stages, Lyme disease can be cured with antibiotics. Without treatment, complications involving the joints, heart, and nervous system can occur. But these symptoms are still treatable and curable. In rare cases, a person keeps having symptoms that interfere with daily life after they have been ... |
liveqa-en-016 | QA | LiveQA | My father is having cardiomyopathy through genes. He is 83 now. He was absoulutely normal till now. recently he is getting breathlessness. and he was admitted to the hospital twice. The doctors are telling that multi dieases are attacking his heart. I just want to know exactly what is happening and what precautions tha... | The outlook depends on many different things, including: - Cause and type of cardiomyopathy - How well the condition responds to treatment - The severity of the heart problem Heart failure is usually a long-term (chronic) illness. It may get worse over time. Some people develop severe heart failure. In this ca... |
liveqa-en-017 | QA | LiveQA | Hi, My name is [NAME] from india i have suffering from typhoid please give me solution i have one question i had got treatment from one year but i am not well now give me solution? | Fluids and electrolytes may be given by IV (into a vein) or you may be asked to drink water with electrolyte packets. Antibiotics are given to kill the bacteria. There are increasing rates of antibiotic resistance throughout the world, so your health care provider will check current recommendations before choosing an ... |
liveqa-en-018 | QA | LiveQA | atypical pnuemonia. what is the possibility of atypical pneumonia occurring again less than a month after treatment? | Most patients with pneumonia due to mycoplasma or chlamydophila get better with the right antibiotics. Legionella pneumonia can be severe. It can lead to problems, especially in patients with kidney failure, diabetes, COPD, or a weak immune system. It can also lead to death. |
liveqa-en-019 | QA | LiveQA | Can u please send stuff on fibromyalgia as well | Fibromyalgia is a common syndrome in which a person has long-term pain, spread throughout the body. The pain is most often linked to fatigue, sleep problems, headaches, depression, and anxiety. People with fibromalgia may also have tenderness in the joints, muscles, tendons, and other soft tissues. |
liveqa-en-020 | QA | LiveQA | Can u please send stuff on fibromyalgia as well | SummaryFibromyalgia is a disorder that causes muscle pain and fatigue. People with fibromyalgia have "tender points" on the body. Tender points are specific places on the neck, shoulders, back, hips, arms, and legs. These points hurt when pressure is put on them. People with fibromyalgia may also have other symptoms, s... |
liveqa-en-021 | QA | LiveQA | It was really helpful after reading about type 1 diabetes but would like some more suggestions from you .my friend is 35 year old and its been 1 year of his diabetes n his sugar level is around 100 or 120 OR SO.. each time he tests his sugar level. is there ANY COMPLICATIONS? HE ALSO GO FOR EXERCISES AND BLOOD TEST EVE... | After many years, diabetes can lead to serious health problems: - You could have eye problems, including trouble seeing (especially at night) and sensitivity to light. You could become blind. - Your feet and skin could develop sores and infections. If you have these sores for too long, your foot or leg may need to be... |
liveqa-en-022 | QA | LiveQA | I just read an article submitted by you that stated your research shows that you've identified the mechanism that causes burning mouth syndrome. Also because of these findings you can find a treatment. I've had this for 15 yrs and am just holding on. When will a good treatment be available?? I belong to a group of ove... | If the underlying cause of burning mouth syndrome is determined, treatment is aimed at the triggering factor(s). If no cause can be found, treatment can be challenging. The following are potential therapies for burning mouth syndrome; we strongly recommend that you work with your health care provider in determining whi... |
liveqa-en-023 | QA | LiveQA | I'm looking for books about hypotension/low blood pressure. Can you suggest any that I might be able to purchase? | Summary You've probably heard that high blood pressure is a problem. Sometimes blood pressure that is too low can also cause problems. Blood pressure is the force of your blood pushing against the walls of your arteries. Each time your heart beats, it pumps out blood into the arteries. Your blood pressure is highest wh... |
liveqa-en-024 | QA | LiveQA | My Daughter have Distal renal tubular acidosis. we are from Mexico, and we ae woundering if can send to us more infomation. maybe you can reccommend to us a association???? i don?t know | Distal renal tubular acidosis is a disease that occurs when the kidneys do not properly remove acids from the blood into the urine. As a result, too much acid remains in the blood (called acidosis). |
liveqa-en-025 | QA | LiveQA | I would like to learn more about my condition. Please send me any literature you feel I could use. thanks, [NAME] | Klinefelter syndrome is a genetic condition that occurs in males when they have an extra X chromosome. |
liveqa-en-026 | QA | LiveQA | I would like to learn more about my condition. Please send me any literature you feel I could use. thanks, [NAME] | Klinefelter syndrome is a chromosomal condition that affects male physical and cognitive development. Its signs and symptoms vary among affected individuals. Affected individuals typically have small testes that do not produce as much testosterone as usual. Testosterone is the hormone that directs male sexual developme... |
liveqa-en-027 | QA | LiveQA | How do I get rid of these little devils? Me and My mom have tried so many things to get rid of these bugs and they just don't go away were the family that takes 2 showers and now about 3 showers a day we never understood how they could have infected us but I was just wondering is washing our clothes the best bet to get... | To get rid of lice, take the following important steps: - Bathe regularly to get rid of lice and their eggs. - Change your clothes often. - Wash clothes in hot water (at least 130°F/54°C) and machine dry using the hot cycle. - Items that can't be washed, such as stuffed toys, mattresses, or furniture, can be th... |
liveqa-en-028 | QA | LiveQA | I have a list of questions about Tay sachs disease and clubfoot 1. what is TSD/Clubfoot, and how does it effect a baby 2. what causes both? can it be prevented, treated, or cured 3. How common is TSD? how common is Clubfoot 4. How can your "agency" help a women/couple who are concerned about this congeni... | Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward. The cause of this condition is not known, although it may be passed down through families in some cases. This condition occurs in about 1 out of every 1,000 births. Treatment may involve moving the foot into the... |
liveqa-en-029 | QA | LiveQA | I have a list of questions about Tay sachs disease and clubfoot 1. what is TSD/Clubfoot, and how does it effect a baby 2. what causes both? can it be prevented, treated, or cured 3. How common is TSD? how common is Clubfoot 4. How can your "agency" help a women/couple who are concerned about this congeni... | Clubfoot is the most common congenital disorder of the legs. It can range from mild and flexible to severe and rigid. The cause is not known, but the condition may be passed down through families in some cases. Risk factors include a family history of the disorder and being male. The condition occurs in about 1 out of... |
liveqa-en-030 | QA | LiveQA | I have a list of questions about Tay sachs disease and clubfoot 1. what is TSD/Clubfoot, and how does it effect a baby 2. what causes both? can it be prevented, treated, or cured 3. How common is TSD? how common is Clubfoot 4. How can your "agency" help a women/couple who are concerned about this congeni... | Tay-Sachs disease is a rare inherited disorder that causes progressive destruction of nerve cells in the brain and spinal cord. Tay-Sachs is caused by the absence of a vital enzyme called hexosaminidase-A (Hex-A). Without Hex-A, a fatty substance, or lipid, called GM2 ganglioside accumulates abnormally in cells, especi... |
liveqa-en-031 | QA | LiveQA | I have a list of questions about Tay sachs disease and clubfoot 1. what is TSD/Clubfoot, and how does it effect a baby 2. what causes both? can it be prevented, treated, or cured 3. How common is TSD? how common is Clubfoot 4. How can your "agency" help a women/couple who are concerned about this congeni... | Tay-Sachs disease is a rare inherited disorder that progressively destroys nerve cells (neurons) in the brain and spinal cord. The most common form of Tay-Sachs disease becomes apparent in infancy. Infants with this disorder typically appear normal until the age of 3 to 6 months, when their development slows and muscl... |
liveqa-en-032 | QA | LiveQA | I have a list of questions about Tay sachs disease and clubfoot 1. what is TSD/Clubfoot, and how does it effect a baby 2. what causes both? can it be prevented, treated, or cured 3. How common is TSD? how common is Clubfoot 4. How can your "agency" help a women/couple who are concerned about this congeni... | There is no known way to prevent this disorder. Genetic testing can detect if you are a carrier of the gene for this disorder. If you or your partner are from an at-risk population, it is recommended that you undergo testing before starting a family. Testing the amniotic fluid can diagnose Tay-Sachs disease in the womb... |
liveqa-en-033 | QA | LiveQA | I have a list of questions about Tay sachs disease and clubfoot 1. what is TSD/Clubfoot, and how does it effect a baby 2. what causes both? can it be prevented, treated, or cured 3. How common is TSD? how common is Clubfoot 4. How can your "agency" help a women/couple who are concerned about this congeni... | There is no treatment for Tay-Sachs disease itself, only ways to make the person more comfortable. |
liveqa-en-034 | QA | LiveQA | Are ear lobe creases always heart disease and 100% heart attack pending? What are other causes? I'm 56 have pierced ears but haven't wore earrings in years. In the last 7 years I rarely eat meat and when I do it's chicken or fish maybe beef every 5 years or so and its maybe a hamburger lean. If you do have arterioscler... | A substance called plaque can build up in the walls of your coronary arteries. This plaque is made up of cholesterol and other cells. A heart attack may occur when: - A tear in the plaque occurs. This triggers blood platelets and other substances to form a blood clot at the site that blocks most or all of the oxygen-... |
liveqa-en-035 | QA | LiveQA | Are ear lobe creases always heart disease and 100% heart attack pending? What are other causes? I'm 56 have pierced ears but haven't wore earrings in years. In the last 7 years I rarely eat meat and when I do it's chicken or fish maybe beef every 5 years or so and its maybe a hamburger lean. If you do have arterioscler... | Coronary Heart Disease A heart attack happens if the flow of oxygen-rich blood to a section of heart muscle suddenly becomes blocked and the heart can't get oxygen. Most heart attacks occur as a result of coronary heart disease (CHD). CHD is a condition in which a waxy substance called plaque builds up inside of the co... |
liveqa-en-036 | QA | LiveQA | my son born with alopicia totalis and swealling around the eyes , we have done for him Whole Exome Sequencing , they identified a heterozygous likely pathogenic variant in the SOX18 gene, which supports the clinical diagnosis of hypotrichosis-lymphedema-telangiectasia syndrome , i would like to know if i can trat this... | Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS) is a rare condition that, as the name suggests, is associated with sparse hair (hypotrichosis), lymphedema, and telangiectasia, particularly on the palms of the hands. Symptoms usually begin at birth or in early childhood and become worse over time. HLTS is though... |
liveqa-en-037 | QA | LiveQA | What happen to diabetes patient Getting blood sugar increase by which of body in brain or stomach or urine bladder.why urine bladder become more weight that any other part of body. | SummaryDiabetes means your blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not make or use insulin well. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high ... |
liveqa-en-038 | QA | LiveQA | TMAU. Please find a way to research TMAU And how to cure it with gene therapy. I'm tired kg smelling like fish/feces And getting talked about everyday of my life. | Trimethylaminuria is a disorder in which the body is unable to break down trimethylamine, a chemical compound that has a pungent odor. Trimethylamine has been described as smelling like rotting fish, rotting eggs, garbage, or urine. As this compound builds up in the body, it causes affected people to give off a strong ... |
liveqa-en-039 | QA | LiveQA | I would appreciate it if you can send me or email me some exercises for a person who is a stroke victim. I am unable to walk due to a arthritic knee. otherwise I am flexable.. my home address is [CONTACT], My email is [CONTACT] (mailto:[CONTACT]) Thank you, [NAME] | A stroke is a medical emergency. Quick treatment is needed. Call 9-1-1 or your local emergency number right away or seek urgent medical care at the first signs of a stroke. People who are having stroke symptoms need to get to a hospital as quickly as possible.- If the stroke is caused by a blood clot, a clot-busting dr... |
liveqa-en-040 | QA | LiveQA | I would appreciate it if you can send me or email me some exercises for a person who is a stroke victim. I am unable to walk due to a arthritic knee. otherwise I am flexable.. my home address is [CONTACT], My email is [CONTACT] (mailto:[CONTACT]) Thank you, [NAME] | Generally there are three treatment stages for stroke: prevention, therapy immediately after the stroke, and post-stroke rehabilitation. Therapies to prevent a first or recurrent stroke are based on treating an individual's underlying risk factors for stroke, such as hypertension, atrial fibrillation, and diabetes. Acu... |
liveqa-en-041 | QA | LiveQA | I would appreciate it if you can send me or email me some exercises for a person who is a stroke victim. I am unable to walk due to a arthritic knee. otherwise I am flexable.. my home address is [CONTACT], My email is [CONTACT] (mailto:[CONTACT]) Thank you, [NAME] | With stroke, treatment depends on the stage of the disease. There are three treatment stages for stroke: prevention, therapy immediately after stroke, and rehabilitation after stroke. Stroke treatments include medications, surgery, and rehabilitation. |
liveqa-en-042 | QA | LiveQA | Is there any way you could send me information on both these heart conditions? My son has to get tested for them eventually and I would just like information to understand the conditions of both of them more. | Hypertrophic cardiomyopathy (HCM) is a condition in which the heart muscle becomes thick. Often, only 1 part of the heart is thicker than the other parts. The thickening can make it harder for blood to leave the heart, forcing the heart to work harder to pump blood. It also can make it harder for the heart to relax and... |
liveqa-en-043 | QA | LiveQA | Is there any way you could send me information on both these heart conditions? My son has to get tested for them eventually and I would just like information to understand the conditions of both of them more. | Wolff-Parkinson-White syndrome is a condition in which there is an extra electrical pathway of the heart. The condition can lead to periods of rapid heart rate (tachycardia). Wolff-Parkinson-White syndrome is one of the most common causes of fast heart rate problems in infants and children. |
liveqa-en-044 | QA | LiveQA | I'm a vietnam navy veteran whose traditional stroke thearapy has failed miserably | Surgery can be used to prevent stroke, to treat stroke, or to repair damage to the blood vessels or malformations in and around the brain. - Carotid endarterectomy is a surgical procedure in which a surgeon removes fatty deposits, or plaque, from the inside of one of the carotid arteries. The procedure is performed to ... |
liveqa-en-045 | QA | LiveQA | My brother need treatment for muscular dystrophy | There are no known cures for the various muscular dystrophies. The goal of treatment is to control symptoms. Physical therapy may help maintain muscle strength and function. Leg braces and a wheelchair can improve mobility and self-care. In some cases, surgery on the spine or legs may help improve function. Corticost... |
liveqa-en-046 | QA | LiveQA | Hi, I am a grade 12 student who is doing a research assignment on neurological disorders. Do you believe that there will ever be a bonafide cure for Multiple Sclerosis? If so, what kind of time frame would put on this cure? | There is no known cure for MS at this time. But, there are treatments that may slow the disease. The goal of treatment is to control symptoms and help you maintain a normal quality of life. Medicines are often taken long-term. These include:- Medicines to slow the disease- Steroids to decrease the severity of attacks- ... |
liveqa-en-047 | QA | LiveQA | Hi, I am a grade 12 student who is doing a research assignment on neurological disorders. Do you believe that there will ever be a bonafide cure for Multiple Sclerosis? If so, what kind of time frame would put on this cure? | There is as yet no cure for MS. Many patients do well with no therapy at all, especially since many medications have serious side effects and some carry significant risks. However, three forms of beta interferon (Avonex, Betaseron, and Rebif) have now been approved by the Food and Drug Administration for treatment of r... |
liveqa-en-048 | QA | LiveQA | Is optic atrophy ginetic and what cause it? | There are many causes of optic atrophy. The most common is poor blood flow. This is called ischemic optic neuropathy. The problem most often affects older adults. The optic nerve can also be damaged by shock, toxins, radiation, and trauma. Eye diseases, such as glaucoma, can also cause a form of optic nerve atrophy. Th... |
liveqa-en-049 | QA | LiveQA | What is the connection (if any) between Essential Tremor and Parkinsons and what is the best treatment for Essential Tremor? | Essential tremor is the most common movement disorder. It is characterized by involuntary and rhythmic shaking (tremor), especially in the hands, without any other signs or symptoms. It is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head t... |
liveqa-en-050 | QA | LiveQA | What is the connection (if any) between Essential Tremor and Parkinsons and what is the best treatment for Essential Tremor? | Treatment may not be needed unless the tremors interfere with your daily activities or cause embarrassment. HOME CARE For tremors made worse by stress, try techniques that help you relax. For tremors of any cause, avoid caffeine and get enough sleep. For tremors caused or made worse by a medication, talk to your doct... |
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