document_id int64 185 2.68k | context stringlengths 2.88k 70.8k | question stringlengths 11 194 | id int64 225 5.32k | answer stringlengths 1 933 | answer_start int64 157 69k |
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630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the main cause of HIV-1 infection in children? | 262 | Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. | 370 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What plays the crucial role in the Mother to Child Transmission of HIV-1 and what increases the risk | 276 | DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission. | 2,003 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How many children were infected by HIV-1 in 2008-2009, worldwide? | 278 | more than 400,000 children were infected worldwide, mostly through MTCT and 90% of them lived in sub-Saharan Africa. | 2,291 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is the role of C-C Motif Chemokine Ligand 3 Like 1 (CCL3L1) in mother to child transmission of HIV-1? | 316 | High copy numbers of CCL3L1, a potent HIV-1 suppressive ligand for CCR5, are associated with higher chemokine production and lower risk of MTCT of HIV-1 among South African infants | 28,143 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | What is DC-GENR and where is it expressed? | 305 | Dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)) can interact with a plethora of pathogens including HIV-1 and is expressed in placental capillary endothelial cells | 3,207 |
630 | Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752805/
Boily-Larouche, Geneviève; Iscache, Anne-Laure; Zijenah, Lynn S.; Humphrey, Jean H.; Mouland, Andrew J.; Ward, Brian J.; Roger, Michel
2009-10-07
DOI:10.1371/journal.... | How does the presence of DC-SIGNR affect the MTCT of HIV-1? | 306 | the presence of DC-SIGNR at the placental endothelial cell surface may protect infants from HIV-1 infection by capturing virus and promoting its degradation/presentation. | 28,910 |
630 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | Why do low levels of DC-SIGNR enhance Mother to Child Transmission of HIV-1? | 307 | "in placenta containing low levels of DC-SIGNR, HIV-1 would preferentially binds CCR5 on endothelial(...TRUNCATED) | 29,090 |
630 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | What is the percentage of Mother to Child Transmission of HIV-1, when there is no intervention? | 277 | "Without specific interventions, the rate of HIV-1 mother-tochild transmission (MTCT) is approximate(...TRUNCATED) | 2,137 |
630 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | Does C-C chemokine receptor type 5 (CCR5) affect the transmission of HIV-1? | 312 | "Genetic variants in CCR5 have been shown to influence vertical transmission of HIV-1. CCR5 promoter(...TRUNCATED) | 27,719 |
630 | "Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1\n(...TRUNCATED) | How does Mannanose Binding Lectin (MBL) affect elimination of HIV-1 pathogen? | 318 | "Mannose-binding lectin (MBL) is an innate immune receptor synthesised in the liver and secreted in (...TRUNCATED) | 28,335 |
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