entities sequence | text stringlengths 10 3.62k | split stringclasses 3
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|---|---|---|
[] | DPP6 as a candidate gene for neuroleptic-induced tardive dyskinesia. | train |
[
"haloperidol"
] | We implemented a two-step approach to detect potential predictor gene variants for neuroleptic-induced tardive dyskinesia (TD) in schizophrenic subjects. First, we screened associations by using a genome-wide (Illumina HumanHapCNV370) SNP array in 61 Japanese schizophrenia patients with treatment-resistant TD and 61 Ja... | train |
[] | Nanosilver effects on growth parameters in experimental aflatoxicosis in broiler chickens. | train |
[
"aflatoxin"
] | Aflatoxicosis is a cause of economic losses in broiler production. In this study, the effect of one commercial nanocompound, Nanocid (Nano Nasb Pars Co., Iran) was evaluated in reduction of aflatoxin effects on the growth and performance indices in broiler chickens suffering from experimental aflatoxicosis. For this, a... | train |
[] | The influence of the intensity of smoking and years of work in the metallurgy on pro-oxidant/antioxidant balance in the blood of smelters. | train |
[
"nitric oxide",
"Mercury"
] | Mercury induces the expression of cyclooxygenase-2 and inducible nitric oxide synthase. | train |
[
"nitric oxide",
"mercury"
] | Nuclear factor-κB (NF-κB) is a transcription factor that mediates the inducible expression of a variety of genes involved in immune and inflammatory responses. NF-κB activation induces numerous proinflammatory gene products including cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). The d... | train |
[
"chromium"
] | Toxic effects of chromium on tannery workers at Sialkot (Pakistan). | train |
[
"graphite",
"chromium",
"Chromium",
"malondialdehyde"
] | Chromium is widely used in the leather industry, and tannery workers are under constant threat of adverse health effects due to its excessive exposure. Our objective was to find out the toxic effects of chromium on tannery workers at Sialkot, Pakistan. A total of 240 males consisting of 120 workers from tanneries at Si... | train |
[] | Fish, contaminants and human health: quantifying and weighing benefits and risks. | train |
[] | This paper describes a quantitative risk-benefit assessment of fish consumption. We compare the net health effect expressed in DALYs of two scenarios. The reference scenario is the current fish intake of the Dutch population, which is less than what is recommended by the health authorities. The alternative scenario des... | train |
[] | Protective effect of honey against cigarette smoke induced-impaired sexual behavior and fertility of male rats. | train |
[] | Cigarette smoking is associated with sexual dysfunction and impaired fertility in males. The aim of this study was to determine the potential protective effect of honey against the toxic effect of cigarette smoke (CS) on sexual behavior and fertility of male rats. Thirty-two adult Sprague-Dawley rats were randomly divi... | train |
[] | Allelopathic activity studies of Mikania scandens. | train |
[
"mikanolide"
] | Preliminary investigation of a number of plant extracts for allelopathic activity using seed germination inhibition bioassay showed a promising activity of the water extract of the aerial parts of Mikania scandens. Activity-guided fractionation of the M. scandens extract led to the isolation of the highly allelopathic ... | train |
[
"polycyclic aromatic hydrocarbons"
] | Detection of polycyclic aromatic hydrocarbons in different types of processed foods. | train |
[
"benzo(a)anthracene",
"fluoranthene",
"cyclohexane",
"benzoflouroanthene",
"benzo(a)pyrene",
"Polycyclic aromatic hydrocarbons",
"benzo(e)pyrene",
"PCAHs",
"methanolic potassium hydroxide",
"pyrene"
] | Polycyclic aromatic hydrocarbons (PCAHs), particularly those with a high molecular weight, have been classified as probable carcinogens to humans. The aim of the present study is to determine the levels of PCAHs in samples of meat, fish, chicken, fried potato, and toasted bread, which will be thermally processed using ... | train |
[
"Thiovit"
] | Effect of Thiovit(R) Jet on the structure of thoracic microtrichia/trichomes in Drosophila melanogaster. | train |
[
"Thiovit",
"captafol",
"captan"
] | Widely used fungicides and pesticides are known to have profound effect on several nontarget organisms, which is a cause of concern. The present study aims to demonstrate the effect of a fungicide, Thiovit(®) Jet on the structure of epidermal microtrichia (trichome) of the dorsal thorax in Drosophila melanogaster. Exte... | train |
[] | Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants. | train |
[
"MTT",
"3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide"
] | Herbal and traditional medicines are being widely used in practice in many countries for their benefits of treating different ailments. A large number of plants in Morocco were used in folk medicine to treat immune-related disorders. The objective of this study is to evaluate the immunomodulatory activity of protein ex... | train |
[
"steroidal saponins"
] | Determination of three steroidal saponins from Ophiopogon japonicus (Liliaceae) via high-performance liquid chromatography with mass spectrometry. | train |
[
"steroidal saponins",
"acetonitrile",
"formic acid"
] | A simple and accurate analytical method was developed for simultaneous quantification of three steroidal saponins in the roots of Ophiopogon japonicus via high-performance liquid chromatography (HPLC) with mass spectrometry (MS) in this study. Separation was performed on a Tigerkin C(18) column and detection was perfor... | train |
[
"steroidal glycosides"
] | Three new steroidal glycosides from roots of Reineckia carnea. | train |
[
"kitigenin-5β-O-β-D-glucopyranoside",
"MTT",
"reinocarnoside A (1), B (2) and C (3)",
"furostanol",
"(25S)-1β,3β,4β-trihydroxyspirostan-5β-yl-O-β-D-glucopyranoside",
"spirostanols"
] | Two new spirostanols and a new furostanol, reinocarnoside A (1), B (2) and C (3), were isolated from the roots of Reineckia carnea, together with two known compounds, (25S)-1β,3β,4β-trihydroxyspirostan-5β-yl-O-β-D-glucopyranoside (4), kitigenin-5β-O-β-D-glucopyranoside (5). The structures of three new compounds were el... | train |
[] | Seasonal variation in biomarkers in blue mussel (Mytilus edulis), Icelandic scallop (Chlamys islandica) and Atlantic cod (Gadus morhua): implications for environmental monitoring in the Barents Sea. | train |
[
"triclosan"
] | Drought episode modulates the response of river biofilms to triclosan. | train |
[
"TCS",
"triclosan",
"phosphate"
] | The consequences of global change on rivers include altered flow regime, and entrance of compounds that may be toxic to biota. When water is scarce, a reduced dilution capacity may amplify the effects of chemical pollution. Therefore, studying the response of natural communities to compromised water flow and to toxican... | train |
[] | Determination of chemical composition and genotoxic effects of essential oil obtained from Nepeta nuda on Zea mays seedlings. | train |
[
"sodium dodecyl sulphate",
"4aα,7β,7aα-nepetalactone",
"elemol",
"germacrene",
"polyacrylamide",
"SDS"
] | We aimed to determine the genotoxic potential of essential oil (EO) obtained from Nepeta nuda. The chemical content of EO was measured via gas chromatography/mass spectrometry. The most abundant contents were 4aα,7β,7aα-nepetalactone (18.10%), germacrene (15.68%) and elemol (14.38%). For genotoxic effects of EO, Zea ma... | train |
[
"aluminum"
] | Lethality, accumulation and toxicokinetics of aluminum in some tissues of male albino rats. | train |
[
"Al",
"aluminum",
"Aluminum"
] | In the present work, the lethality percentiles including median lethal doses (LD50), accumulation, distribution and toxicokinetics of aluminum in the liver, kidney, intestine, brain and serum of male albino rats, following a single oral administration were studied throughout 1, 3, 7, 14 and 28 days. The estimated LD50 ... | train |
[] | RETRACTED: Biochemical changes in the Beluga Huso huso exposed to acute crude diesel oil. | train |
[] | RETRACTED. | train |
[
"monoglyceride"
] | Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. | train |
[
"phosphoinositides",
"phosphatidic acid",
"phosphatidylinositol",
"PI(3,4,5)P3",
"phosphoinositol(3,4,5)P3",
"phosphoinositol(3,4)P2",
"monoglyceride",
"phosphoinositol(3,5)P2"
] | Human monoglyceride lipase (MGL) is a recently identified lipase and very little is known about its regulation and function in cellular regulatory processes, particularly in context to human malignancy. In this study, we investigated the regulation and function of MGL in human cancer(s) and report that MGL expression w... | train |
[] | Chemical constituents of the hemiparasitic plant Phoradendron brachystachyum DC Nutt (Viscaceae). | train |
[
"acacetin",
"triacontanol",
"moronic acid",
"acetone",
"β-sitosteryl and stigmasteryl linoleates",
"oleanolic acid",
"flavonoids",
"β-sitosterol",
"squalene, α- and β-amyrin",
"lupenone",
"betulonic acid",
"morolic acid",
"betulin aldehyde",
"acacetin 7-methyl ether",
"oleanolic aldehyde... | Phoradendron brachystachyum is a hemiparasitic plant widely distributed in México that belongs to the Viscaceae family. It has been commonly used in folk medicine as a substitute for the European mistletoe. In this chemical study, morolic acid was isolated as the major component (47.54% of the total composition of acet... | train |
[
"rapamycin"
] | MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells. | train |
[
"RAP",
"Rapamycin"
] | When mTOR inhibitor rapalogs prevent cap-dependent translation of cell-cycle proteins like c-myc, continuing tumor cell growth depends on cap-independent translation, which is mediated by internal ribosome entry sites (IRESes) located in the 5'-UTR (untranslated region) of transcripts. To investigate if rapalog-induced... | train |
[] | Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. | train |
[
"gefitinib",
"WP1066",
"phosphatidyl inositol"
] | The hypothesis of cancer stem cells has been proposed to explain the therapeutic failure in a variety of cancers including lung cancers. Previously, we demonstrated acquisition of epithelial-mesenchymal transition, a feature highly reminiscent of cancer stem-like cells, in gefitinib-resistant A549 cells (A549/GR). Here... | train |
[] | Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS). | train |
[] | The oral delivery of hydrophobic drug presents a major challenge because of the low aqueous solubility of such compounds. Self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulat... | train |
[] | Chemical composition and antibacterial activity of the essential oil from Mentha requienii Bentham. | train |
[
"pulegone",
"menthone",
"isomenthone",
"limonene",
"isopulegone"
] | The chemical composition of essential oil obtained by hydrodistillation of the fresh aerial parts of Mentha requienii Bentham (Lamiaceae) collected on the Gennargentu Mountains (Sardinia, Italy) has been investigated by gas chromatography and gas chromatography-mass spectrometry. The main constituents that resulted wer... | train |
[
"Carbon",
"withanolide A"
] | Carbon sources and medium pH affects the growth of Withania somnifera (L.) Dunal adventitious roots and withanolide A production. | train |
[
"carbon",
"withanolide A",
"sucrose"
] | This work deals with optimisation of adventitious root suspension culture of Withania somnifera (L.) Dunal (Solanaceae) for the production of biomass and withanolide A and we investigated the effect of carbon source and the initial medium pH on growth and production of withanolide A in adventitious root cultures of Wit... | train |
[
"nimesulide"
] | Comparison of pharmacokinetics in beagle dogs of nimesulide bilayer tablets with dispersible tablets. | train |
[
"nimesulide"
] | The purpose of this study was to compare the in vitro release and the in vivo pharmacokinetics of bilayer tablets with the conventional dispersible tablets of nimesulide. The tablets were administered to beagle dogs and the plasma levels of nimesulide were determined by high-performance liquid chromatography-MS/MS. The... | train |
[
"PLA",
"Ivermectin"
] | Injectable PLA-based in situ forming implants for controlled release of Ivermectin a BCS Class II drug: solvent selection based on physico-chemical characterization. | train |
[
"2-pyrrolidone",
"PLA",
"triacetine",
"NMP",
"benzyl benzoate",
"ivermectin",
"poly(D,L-lactide)",
"IVM",
"N-methyl-2-pyrrolidone"
] | In situ forming implants (ISI) prepared from biodegradable polymers such as poly(D,L-lactide) (PLA) and biocompatible solvents can be used to obtain sustained drug release after parenteral administration. The aim of this work was to study the effect of several biocompatible solvents with different physico-chemical prop... | train |
[] | Toxic effects of 50 Hz electromagnetic field on memory consolidation in male and female mice. | train |
[] | In this study, the effect of exposure to an 8 mT, 50 Hz extremely low-frequency electromagnetic field (ELF EMF) on memory consolidation of adult male and female mice was studied. For this purpose male and female mice were randomly distributed among six groups (n = 10 in each group). Using passive avoidance task, despit... | train |
[
"9,10-seco-9,19-cyclolanostane",
"triterpene"
] | 9,10-seco-9,19-cyclolanostane triterpene from Salix caprea L. (goat willow). | train |
[
"fatty alcohols",
"triterpene",
"1α,3β,25-trihydroxy-9(11)-ene-16-one-9,10-seco-9,19-cyclolanostane"
] | Chemical investigation of low polar solvent extract of Salix caprea through chromatographic techniques led to the isolation of new triterpene as 1α,3β,25-trihydroxy-9(11)-ene-16-one-9,10-seco-9,19-cyclolanostane (1) along with fatty alcohols. The structure of compound 1 was established by IR, HRESI/MS and NMR including... | train |
[] | Chemical constituents of Euphorbia hyberna L. (Euphorbiaceae). | train |
[
"cicloart-23-ene-3β,25-diol",
"triterpenoids",
"ellagic acid",
"glut-5-en-3β-ol",
"3β-O-octadecanoyllupeol",
"24-methylenecicloartan-3β-ol",
"3,3'-di-O-methylellagic acid"
] | Chemical investigation of the aerial part and the roots of Euphorbia hyberna L. subs. hyberna. resulted in the isolation and identification of four triterpenoids (3β-O-octadecanoyllupeol (1), glut-5-en-3β-ol (2), 24-methylenecicloartan-3β-ol (3) and cicloart-23-ene-3β,25-diol (6)) along with the phenolic compounds ella... | train |
[
"diketopiperazine"
] | Structure elucidation of a new natural diketopiperazine from a Microbispora aerata strain isolated from Livingston Island, Antarctica. | train |
[
"trans-cyclo-(D-tryptophanyl-L-tyrosyl)",
"amino acid",
"diketopiperazine",
"Trans-cyclo-(D-tryptophanyl-L-tyrosyl)"
] | A new natural diketopiperazine (1) was obtained from the culture broth of Microbispora aerata strain imbas-11A, isolated from penguin excrements collected on the Antarctic Livingston Island. Compound 1 was purified consecutively by solvent extraction, silica gel column chromatography and preparative HPLC. The structure... | train |
[] | Comparative chemical composition and in vitro antioxidant activities of essential oil isolated from the leaves of Cinnamomum tamala and Pimenta dioica. | train |
[
"superoxide",
"eugenol",
"DPPH"
] | Cinnamomum tamala Nees and Eberm (tejpat) and Pimenta dioica (L.) Merr (pimento) leaves are commonly used for flavouring food and widely used in pharmaceutical preparations because of their hypoglycemic, carminative and stimulant properties. In this study, we compared the chemical composition and antioxidant activities... | train |
[
"iridoid glucosides"
] | Antioxidant and lipoxygenase inhibiting new iridoid glucosides from Caryopteris odorata. | train |
[
"ethylacetate",
"8-O-trans-cinnamoyl caryoptoside",
"8-O-cafeoyl massenoside",
"8-O-trans-cinnamoyl shanzhiside methylester",
"acetyl",
"iridoids",
"8-O-trans-cinnamoyl mussaenoside",
"iridoid glucosides"
] | The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (1-4): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-cafeoyl massenoside (... | train |
[] | Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf. | train |
[
"glucose"
] | Proapoptotic Bcl-2 family members of the Bcl-2 homology (BH)3-only subgroup are critical for the establishment and maintenance of tissue homeostasis and can mediate apoptotic cell death in response to developmental cues or exogenously induced forms of cell stress. On the basis of the biochemical experiments as well as ... | train |
[
"LY541850"
] | Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist. | train |
[
"Glutamate",
"amphetamine",
"LY541850",
"phencyclidine",
"glutamate"
] | Despite the potential therapeutic relevance of group II metabotropic glutamate (mGlu) receptors, there has been a lack of pharmacological tools for separating the roles of mGlu2 and mGlu3 receptor subtypes. LY541850 was claimed from human mGlu receptors expressed in non-neuronal cells to be a selective orthosteric mGlu... | train |
[] | Antiproliferative and antiangiogenic properties of horse chestnut extract. | train |
[
"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide"
] | This study was designed to examine the in vitro antiproliferative effect of the horse chestnut extract (HCE) on cancer cell lines. Furthermore, we have investigated the in vitro effect of HCE on some angiogenic events by using human umbilical vein endothelial cells. The cell proliferation was evaluated by 3-(4,5-dimeth... | train |
[
"4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine"
] | Synthesis of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine derivatives as potent antimicrobial agent. | train |
[
"3-alkyl-2,6-diarylpiperidin-4-one",
"piperdin-4-ol",
"Grignard reagent",
"4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine"
] | A series of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine (7-12) have been synthesised by reduction of 3-alkyl-2,6-diarylpiperidin-4-one using the Grignard reagent. Structural assignments and conformational analysis of the compounds were established based on the spectral studies. All the piperdin-4-ol derivatives (7-12) ... | train |
[] | Phytochemical analysis of Gymnema sylvestre and evaluation of its antimicrobial activity. | train |
[
"diethyl ether",
"oleic acid",
"eicosane",
"stigmasterol",
"saponins",
"acetone",
"chloroform",
"vitamin E"
] | Gymnema sylvestre (CS 149), known to be a rich source of saponins and other valuable phytochemicals, has been analysed for antimicrobial activity. The chloroform extracts of aerial and root parts of G. sylvestre exhibited higher antimicrobial activity as compared to diethyl ether and acetone. The root extracts of chlor... | train |
[] | Plant proteins, minerals and trace elements of Eurycoma longifolia (Tongkat Ali). | train |
[
"calcium",
"sodium dodecyl sulphate polyacrylamide",
"potassium",
"magnesium",
"arsenic",
"Isoleucine"
] | A water extraction method has been used to extract plant proteins from the roots of Eurycoma longifolia harvested from Perak and Pahang, Malaysia. On the basis of the spectroscopic Bradford assay, Tongkat Ali Perak and Pahang contained 0.3868 and 0.9573 mg mL(-1) of crude protein, respectively. The crude proteins were ... | train |
[] | In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. | train |
[
"tetracycline",
"doxycycline"
] | Although significant progress has been made in understanding the importance of Wnt signaling in the initiation of colorectal cancer, less is known about responses that accompany the reversal of oncogenic Wnt signaling. The aim of this study was to analyze in vivo and in vitro responses to an 'ideal' Wnt pathway inhibit... | train |
[] | miR-143 regulates hexokinase 2 expression in cancer cells. | train |
[
"glucose",
"oxygen",
"ATP",
"fatty acids"
] | Tumor cells activate pathways that facilitate and stimulate glycolysis even in the presence of adequate levels of oxygen in order to satisfy their continuous need of molecules, such as nucleotides, ATP and fatty acids, necessary to support their rapid proliferation. Accordingly, a variety of human tumors are characteri... | train |
[
"Glaucogenin E",
"C21",
"steroid"
] | Glaucogenin E, a new C21 steroid from Cynanchum stauntonii. | train |
[
"Glaucogenin E",
"C(21)",
"steroid"
] | Glaucogenin E (1), a new C(21) steroid sapogenin, along with three known ones (2-4) were isolated from the rhizomes of Cynanchum stauntonii (Decne.) Schltr. ex Levl. Their structures were established mainly by the spectroscopic analysis, including 2D NMR. All the isolated compounds were evaluated for their cytotoxicity... | train |
[
"boeravinone E",
"boeravinone B"
] | RP-HPLC method for the simultaneous quantitation of boeravinone E and boeravinone B in Boerhaavia diffusa extract and its formulation. | train |
[
"boeravinone E and B",
"boeravinone B",
"rotenoids",
"orthophosphoric acid",
"acetonitrile",
"boeravinone E"
] | A high-performance liquid chromatography method was developed and validated for the simultaneous quantitation of two major rotenoids, boeravinone E and boeravinone B, in Boerhaavia diffusa extract and its formulation. Chromatographic separation was carried out on an Inertsil ODS-3 column by using gradient mobile phase ... | train |
[] | Screening of ecotoxicological, qualitative and reproductive variables in male European sea bass Dicentrarchus labrax (L.) reared in three different fish farms: Facility location and typology. | train |
[
"fluoro-indomethacin"
] | Evaluation of the physicochemical and biopharmaceutical properties of fluoro-indomethacin. | train |
[
"18F",
"indomethacin",
"IMC",
"18F-IMC",
"fluoro-indomethacin",
"F-IMC"
] | Drug nanocarriers have shown great potential in therapy and as diagnostic probes, e.g. in imaging of cancer and inflammation. Imaging can be applied to localize the carrier or the drug itself in the body and/or tissues. In this particular case it is important that drug molecules have the characteristics for possible de... | train |
[
"furostanol",
"saponins"
] | New furostanol saponins from the rhizomes of Tupistra chinensis. | train |
[
"furostanol",
"saponins",
"polyhydroxyl",
"saponin"
] | Three new furostanol saponins (1-3), including a polyhydroxyl saponin, were isolated from the rhizomes of Tupistra chinensis. The structures of these compounds were identified by NMR, MS spectral data and chemical methods. | train |
[
"AMPA",
"glutamate"
] | mGlu5R promotes glutamate AMPA receptor phosphorylation via activation of PKA/DARPP-32 signaling in striatopallidal medium spiny neurons. | train |
[
"Glutamate",
"AMPA",
"dopamine",
"(R,S)-3,5-dihydroxyphenylglycine",
"DHPG",
"glutamate",
"adenosine",
"2-methyl-6-(phenylethynyl)pyridine hydrochloride",
"cAMP",
"MPEP",
"Ser"
] | Group I metabotropic glutamate receptors (mGluRs), which comprise mGlu1Rs and mGlu5Rs, are enriched in striatal medium spiny neurons (MSNs), where they modulate glutamatergic transmission. Here, we have examined the effect of group I mGluRs on the regulation of the state of phosphorylation of the GluA1 subunit of the A... | train |
[
"rebamipide",
"poloxamer 407"
] | Physicochemical, pharmacokinetic and pharmacodynamic evaluations of novel ternary solid dispersion of rebamipide with poloxamer 407. | train |
[
"rebamipide",
"Poloxamer 407",
"poloxamer 407",
"NaOH",
"sodium hydroxide"
] | This study was conducted primarily to improve the solubility of rebamipide, a poorly water-soluble anti-ulcer drug, using novel ternary solid dispersion (SD) systems and secondly to evaluate the effect of solubility enhancement on its pharmacokinetic (PK) and pharmacodynamic (PD) profile. After dissolving the three com... | train |
[] | Chitin synthase inhibitors as antifungal agents. | train |
[
"nikkomycin",
"Nikkomycin Z",
"polyoxin"
] | Increased risk of fungal diseases in immunocompromised patients, emerging fungal pathogens, limited repertoire of antifungal drugs and resistance development against the drugs demands for development of new and effective antifungal agents. With greater knowledge of fungal metabolism efforts are being made to inhibit sp... | train |
[
"carbon dioxide",
"venlafaxine",
"pregabalin"
] | Evaluation of the effects of venlafaxine and pregabalin on the carbon dioxide inhalation models of Generalised Anxiety Disorder and panic. | train |
[
"CO(2)",
"Venlafaxine",
"lorazepam",
"paroxetine",
"pregabalin",
"venlafaxine",
"benzodiazepines"
] | Previous studies have shown that subjective and objective symptoms of anxiety induced by 7.5% CO(2) inhalation can be attenuated by anxiolytics such as lorazepam and, to a lesser extent, paroxetine. Venlafaxine and pregabalin, two other licensed treatments for Generalised Anxiety Disorder, were used to further investig... | train |
[
"N-isobutyl-4,5-epoxy-2(E)-decenamide"
] | Microwave-assisted synthesis of N-isobutyl-4,5-epoxy-2(E)-decenamide. | train |
[
"2-bromoacetic acid",
"N-isobutyl-4,5-epoxy-2(E)-decenamide",
"Octanal",
"amide"
] | A new and efficient synthesis of a naturally occurring amide alkaloid, N-isobutyl-4,5-epoxy-2(E)-decenamide isolated from the roots of Piper nigrum has been described involving a total of nine steps. Octanal and 2-bromoacetic acid have been used as the starting materials. | train |
[] | Endoplasmic reticulum protein 29 regulates epithelial cell integrity during the mesenchymal-epithelial transition in breast cancer cells. | train |
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