Pubmed Text
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Collection of pubmed 2024 papers. • 11 items • Updated
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8793565 | Transmembrane signaling through CD80 (B7-1) induces growth arrest and cell spreading of human B lymphocytes accompanied by protein tyrosine phosphorylation. | We addressed the issue of the role for CD80 (B7-1) expressed on human B cells in transmembrane signaling. Cross-linking of CD80 on B lymphoma Raji cells induced tyrosine phosphorylation in 160-, 120-, 55-, 46- and 44-kDa proteins, which was inhibited by genistein. CD80-mediated signaling resulted in the inhibition of D... |
8793566 | Secretory component, the receptor for polymeric immunoglobulin, has nothing to do with beta-galactosyltransferase in human milk. | ponent (SC) in external secretions is a soluble form of the polymeric immunoglobulin-receptor that is expressed on the cell membrane of mucosal epithelial cells. beta-(1-4)galactosyl transferase (beta-GT) is an enzyme that transfers galactose to non-reducing N-acetylglucosamine residues on various glycoproteins and is ... |
8793567 | Effect of calcitonin gene-related peptide and vasoactive intestinal peptide on murine CD4 and CD8 T cell proliferation. | The effects of alpha calcitonin gene-related peptide (alpha CGRP) and vasoactive intestinal peptide (VIP) on the proliferation of CD4 and CD8 T-murine lymphocytes were investigated. When stimulated by bination of phorbol 12-myristate-13-acetate (PMA) and calcium ionophore (A23187), both neuropeptides in a range of 10(-... |
8793570 | ACE inhibitors and unilateral renal artery stenosis--what price? | The effects of ACE inhibitors on the stenosed kidney in patients with unilateral arterial stenosis are not well characterised. While there are conflicting reports, some experimental and clinical evidence suggest that the stenosed kidney may undergo atrophy: secondary to effective blood pressure lowering and decreased p... |
8793571 | Evaluation of patients with minimally obstructive coronary artery disease and angina. | Atherosclerotic coronary artery disease is a progressive process adversely affecting the integrity of the coronary vasculature. In past years, most studies have focused on the morphological changes leading promised coronary blood flow in atherosclerosis. However, in recent years it has e apparent that abnormal coronary... |
8793572 | Outpatient cardiac catheterisation. | Cardiac catheterisation is increasingly performed in an outpatient setting. The majority of series of outpatient cardiac catheterisation are in laboratories with immediate access to cardiovascular surgery. However, some units may be sited more distantly, although still generally close to a hospital. Compared to an inpa... |
8793573 | Spontaneous closure of interatrial septal openings in infants: an echocardiographic study. | Four-hundred-and-fifteen neonates were evaluated by echocardiographic means in order to detect interatrial septal openings and were followed for a maximum time of 18 months. In 68.67% of them, interatrial septal openings were present at the first week of life. The defects were larger than 3 mm in 50.18% of these infant... |
8793574 | Intracoronary cyclic-GMP and cyclic-AMP during percutaneous transluminal coronary angioplasty. | We investigated intracoronary cyclic-guanosine monophosphate (c-GMP) levels during percutaneous transluminal coronary angioplasty (PTCA) since experimental studies have shown the endothelial origin of c-GMP production. Intracoronary c-GMP and cyclic adenosine monophosphate (c-AMP) were measured during coronary angiopla... |
8793575 | Use of dopamine in prevention of contrast induced acute renal failure--a randomised study. | We report the use of dopamine in renal doses (5 micrograms/kg/min) to prevent contrast induced nephropathy (CIN). Forty patients with diabetes mellitus who were undergoing coronary angiography were randomly divided into two groups. Gr I (20 patients) was infused with dopamine starting 30 min before cardiac catheterizat... |
8793576 | The prognostic value of serum troponin T in unstable angina. | Cardiac troponin T is a regulatory contractile protein not normally found in blood. Its detection in the circulation has been shown to be a sensitive and specific marker for myocardial cell damage. We used a newly developed enzyme immunoassay for troponin T to determine whether its presence in the serum of patients wit... |
8793577 | Mechanism of the positive inotropic action of cocaine in the guinea pig atrium. | We studied the mechanism of the positive inotropic action of cocaine in isolated guinea pig atria superfused with Tyrode's solution at 31 degrees C while attached to a force transducer to measure peak tension developed, maximum velocity of development of tension, and time to peak tension. Cocaine 2.9 microM enhanced pe... |
8793578 | Jugular venous pressure and pulse wave form in the diagnosis of right ventricular infarction. | Jugular venous pressure (measured clinically) and pulse wave form (recorded at 100 mm/s) were analysed in 44 cases of first acute myocardial infarction and 10 age-matched controls. Patients were divided into different groups according to site of infarction decided by detailed 2-D echocardiography. Raised jugular venous... |
8793580 | Genetic basis of left ventricular remodeling after myocardial infarction. | The purpose of the present study was to assess whether the insertion (I)/deletion (D) polymorphism of the angiotensin converting enzyme (ACE) gene, and the polymorphism of angiotensinogen (AGT) gene with threonine (T) instead of methionine (M) at amino acid 235 in exon 2 (M235T) were associated with left ventricular di... |
8793579 | Contribution of cardiopulmonary indices in the assessment of patients with silent and symptomatic ischemia during exercise testing. | Cardiopulmonary and radionuclear indices were used to evaluate pare cardiac function during exercise testing in patients with symptomatic and silent ischemia. The prised 58 patients aged 35-74 years, divided into three groups: Group I-20 patients (controls) with neither ST depression nor chest pain; Group II-22 patient... |
8793581 | Electrical injury to the heart may cause long-term damage to conducting tissue: a hypothesis and review of the literature. | Electrical injury, particularly alternating current, may lead to disease of conducting tissue, myocardial damage or may cause sudden cardiac death. Subtle abnormalities, particularly of sinus node function, may pose diagnostic difficulties and may not present for many years. The long-term follow-up of patients, perhaps... |
8793582 | Efficiency of heating during radiofrequency catheter ablation of accessory atrioventricular pathways. | Adequate heating with myocardial thermal injury is necessary for successful ablation. This study was designed to examine the relationship between power, temperature, and efficiency of heating during radiofrequency catheter ablation of accessory pathways in 76 patients. During each application of radiofrequency energy, ... |
8793583 | Correlation between late potentials duration and QTc dispersion: Is there a causal relationship? | QTc interval dispersion (QTcd) analysis (difference between maximum and minimum QTc calculated from at least five of the standard 12 ECG leads) and signal-averaged electrocardiograms were performed on 23 patients referred to our coronary care unit because of acute myocardial infarction. Late potentials were considered ... |
8793584 | Heart rate variability in hypertensive subjects. | Hypertension is often associated with findings of sympathetic hyperactivity. Evidence shows that adrenergic receptor stimulation can induce left ventricular hypertrophy. Using an autoregressive algorithm in a power spectrum analysis of heart-rate variability in 14 subjects with mild hypertension (mean age 41 +/- 9.0 ye... |
8793585 | Thallium-201 myocardial perfusion imaging in patients before and after successful percutaneous transluminal coronary angioplasty. | We studied the value of exercise thallium-201 (Tl-201) scintigraphy for evaluation of myocardial perfusion improvement and the detection of restenosis in patients after successful percutaneous transluminal coronary angioplasty (PTCA). Fifty-three patients (43 male and 10 female) ages 38-71 years (mean 55.3) were analys... |
8793586 | Multiplane transoesophageal echocardiography is the only definitive ultrasound approach in adult supravalvular aortic stenosis. | This report describes a rare case of isolated supravalvular aortic stenosis (SVAS) in a 28 year-old female patient. A congenital heart defect, diagnosed at birth, was until 1994 suspected to be a valvular aortic stenosis (VAS). Cardiac catheterization led to the diagnosis of supravalvular aortic stenosis, which could e... |
8793587 | Torsades de pointes induced by transesophageal atrial stimulation after administration of almokalant. | This case-report describes a patient who developed a torsades de pointes tachycardia after infusion of almokalant, a selective class III antiarrhythmic agent. The patient was studied with transesophageal atrial stimulation because of Wolff-Parkinson-White syndrome. After a base-line procedure during which an orthodromi... |
8793588 | Lp(a) levels in Greek patients with heterozygous familial hypercholesterolemia. | We undertook the present study to evaluate the lipid profile in 82 (51 male, 31 female) Greek individuals with heterozygous familial hypercholesterolemia (FH), aged 13-61 years from 22 families. FH heterozygotes had significantly elevated serum Lp(a) levels parison with 82 normal controls. Serum Lp(a) levels were also ... |
8793590 | The role of cytokines in cardiac surgery. | Cytokines are a large and rapidly expanding group of polypeptides produced by many different cell types. Increasing interest has been focused on the role of cytokines as mediators of metabolic, immunological and endocrine responses to surgery. The cytokine response in patients undergoing cardiac surgery during cardiopu... |
8793589 | An unusual case of cardiac tamponade following electrical cardioversion. | The clinical presentation of cardiac tamponade may uncover underlying pericardial disease. We describe a patient who was being treated for lone atrial fibrillation. In this case, direct current cardioversion for recurrence of atrial fibrillation plicated by a life-threatening hemopericardium. A history of asbestos expo... |
8793591 | Preventing the inflammatory response to open-heart surgery: the role of aprotinin and other protease inhibitors. | This review discusses the role of protease inhibition in reducing or preventing certain of the deleterious effects of major surgery. The ability of agents such as aprotinin to inhibit bleeding and reduce the need for donor blood transfusions is now well established. What is less well recognized is that aprotinin is not... |
8793592 | Evidence for morphine downregulating immunocytes during cardiopulmonary bypass in a porcine model. | Cardiopulmonary bypass is associated with both cellular immunosuppression and an inflammatory response. Previous studies have demonstrated that morphine, a naturally occurring substance, can downregulate granulocyte, monocyte and endothelial activity. It can even prevent the activation caused by exposing these cells to... |
8793593 | Hyperstimulation of leukocytes by plasma from cardiopulmonary bypass patients is diminished by alpha-MSH pretreatment. | Cardiopulmonary bypass (CPB) results in a diffuse inflammatory response characterized in part by hyperstimulation of leukocytes. We have previously shown that this hyperstimulation appears to be due, in part, to an increase in the release of biological response modifiers (BRMs) such as cytokines. In the present study, ... |
8793594 | Aprotinin diminishes inflammatory processes. | Many of the recent reports concerning cytokine levels in cardiopulmonary bypass have documented changes in the levels of these trauma indicators. In the present report, we also document their levels but in the presence of Aprotinin. Aprotinin is a protease inhibitor used not only to diminish bleeding, but also to dimin... |
8793595 | Surgical anticipatory stress manifests itself in immunocyte desensitization: evidence for autoimmunoregulatory involvement. | The immunocyte behavior (conformational changes and otion in response to signal molecule challenge) in patients about to undergo elective cardiac surgery was studied to elucidate the effect of psychological anticipatory stress on the immune system. Granulocytes and monocytes from 10 patients and 35 non-surgical control... |
8793596 | Protease activated receptors modulate aortic vascular tone. | The effect of agonists of the known protease activated receptors (PAR), the thrombin and the PAR-2 receptors, on vasoactive mediator release and vascular tone were studied using rings of rat aorta. Stimulation of aortic rings with the thrombin receptor agonist, Trap-14, or the PAR-2 agonist, SLIGRL, resulted in a rapid... |
8793597 | Heparin-coated bypass circuits in cardiopulmonary bypass: improved biocompatibility or not. | Heparin bonding to bypass circuits has been found to reduce plications. Here, this process is reviewed with special attention to markers of inflammation and clinical e. Indicators of inflammation (i.e. cytokine levels, elastase ponents) are decreased when using heparin bonded pared to conventional bypass circuits. The ... |
8793598 | Pharmacokinetics and drug interactions--relevant factors for the choice of a drug. | Pharmacokinetics serve as a useful tool in drug development by identifying the drug's disposition and elimination characteristics, the absorption characteristics of the biopharmaceutical formulation, and the therapeutic dose regimen in various patient populations. Where two or more drugs of a class have a similar effic... |
8793601 | Lack of pharmacokinetic interaction as an equivalence problem. | The demonstration that itant administration of drug B does not affect the pharmacokinetics of drug A can be adequately handled as an equivalence problem. Administration of drug A alone serves as reference and simultaneous administration of drugs A and B as test situation. The range of clinically acceptable variation in... |
8793599 | Pharmacokinetics of pantoprazole in man. | The proton pump inhibitor pantoprazole is a substituted benzimidazole sulphoxide for the treatment of acid-related gastrointestinal diseases such as reflux esophagitis, duodenal and gastric ulcers. Pantoprazole, administered as a 40 mg enteric coated tablet, is quantitatively absorbed. Its absolute bioavailability is 7... |
8793600 | Dose linearity of the pharmacokinetics of the new H+/K(+)-ATPase inhibitor pantoprazole after single intravenous administration. | Pantoprazole is a specific inhibitor of the H+/K(+)-ATPase of the gastric parietal cell. The dose-dependency of a range of pantoprazole pharmacokinetic characteristics was studied. Twelve healthy male subjects were given 10, 20, 40 and 80 mg pantoprazole intravenously according to a randomized, single blind, 4-period c... |
8793602 | Lack of pantoprazole drug interactions in man: an updated review. | This review summarizes the results of pharmacokinetic and pharmacodynamic drug interaction studies in man with pantoprazole, a new, selective proton pump inhibitor. Various mechanisms have to be considered as causes for potential drug-drug interactions. Proton pump inhibitors (PPIs) in general may alter the absorption ... |
8793603 | Lack of influence of pantoprazole on the disposition kinetics of theophylline in man. | The potential influence of pantoprazole (BY1023/SK&F96022), a newly developed selective inhibitor of the gastric H+,K(+)-ATPase, on therapeutic serum theophylline concentrations was investigated in a crossover study in 8 healthy male volunteers (age 25-30 [median 27] years, body weight 63-80 [median 68] kg). Steady-sta... |
8793604 | Pantoprazole lacks interaction with antipyrine in man, either by inhibition or induction. | Substituted benzimidazole inhibitors of the gastric H+/K(+)-ATPase may interact with the cytochrome P450 enzyme system and alter the pharmacokinetics of coadministered drugs, as known for omeprazole. The primary aim of the present studies was to determine whether pantoprazole, a new, selective proton pump inhibitor, mo... |
8793605 | Lack of interaction between pantoprazole and digoxin at therapeutic doses in man. | Substituted benzimidazole inhibitors of the gastric H+/K+ATPase may interact with the cytochrome P450 enzyme system and alter the pharmacokinetics of coadministered drugs. On the other hand, changes in intragastric pH might alter the absorption of other drugs. The primary aim of the present study was to determine wheth... |
8793606 | No influence of pantoprazole on the pharmacokinetics of phenytoin. | Twenty-three healthy, male pleted this doubleblind, randomized, placebo controlled, 2-period crossover study to assess the influence of multiple doses of pantoprazole on single-dose phenytoin pharmacokinetics. During each treatment period, the volunteers received either one 40 mg pantoprazole tablet or placebo for 7 da... |
8793607 | Lack of pharmacokinetic interaction between pantoprazole and diclofenac. | The new H+/K+ ATPase inhibitor pantoprazole is extensively metabolized by the liver. As substituted benzimidazoles may potentially interact with the cytochrome P450 system, the influence of pantoprazole on the pharmacokinetics of the NSAID diclofenac was investigated. Diclofenac is widely used in the treatment of rheum... |
8793608 | Pantoprazole does not interact with nifedipine in man under steady-state conditions. | The new H+/K(+)-ATPase inhibitor pantoprazole is extensively metabolized by the liver. As substituted benzimidazoles can interact with the cytochrome P450 system, the influence of pantoprazole on the steady-state pharmacokinetics of the calcium antagonist nifedipine was investigated. Nifedipine is widely used in the tr... |
8793609 | Beta-adrenoceptor blocking agents for the treatment of heart failure. | Congestive heart failure is associated with high morbidity and mortality. Modification of neurohormonal activation by use of angiotensin converting enzyme inhibitors has been shown to decrease symptoms and prolong survival. More recent evidence has suggested that beta-adrenoceptor blocking agent therapy may be also ben... |
8793610 | Correlations between subjective compliance, objective compliance, and factors determining compliance in geriatric hypertensive patients treated with triamterene and hydrochlorothiazide. | There are correlations between objective and pliances on the one hand and factors pliance (3 times drug intake per day, no support by the family to get over the disease and no nicotine abuse). In agreement with the literature, mainly subjective criteria (due to disease, therapy, doctor, and environment) pliance strongl... |
8793611 | Lack of pantoprazole drug interactions in man: an updated review. | This review summarizes the results of pharmacokinetic and pharmacodynamic drug interaction studies in man with pantoprazole, a new, selective proton pump inhibitor. Various mechanisms have to be considered as causes for potential drug-drug interactions. Proton pump inhibitors (PPIs) in general may alter the absorption ... |
8793612 | Comparison of captopril-thiazide and enalapril-thiazide combinations in the management of mild to moderate black hypertensive patients: how important is diuretic dose and duration of action of the ACE-inhibitor? | A double-blind, randomized, parallel-group study was performed pare the efficacy and tolerability of captopril-thiazide and binations. After a 3-week placebo run-in period, 47 Black patients with mild to moderate essential hypertension (mean 24-hour diastolic blood pressure (BP) > 90 mmHg and < 115 mmHg) were randomize... |
8793613 | Biochemical and clinical assessment of histamine blockade. | The effects of antihistamines on biochemical stress indicators and on psychomotor and physiological functions were studied in 60 healthy patients receiving in a randomized, double-blind study either 25 mg promethazine, 150 mg ranitidine, both drugs or placebo (n = 15 in each group). Different aspects of the premedicati... |
8793614 | Nuclear transplantation from stably transfected cultured cells of Xenopus. | By nuclear transplantation we have generated embryos from enucleated Xenopus eggs and nuclei of stably transfected Xenopus cell lines. We have devised a novel method of transplantation in which cell permeabilization is controlled by a temperature effect on streptolysin O-treated cells. This method is easier and quicker... |
8793615 | The LIM homeodomain protein Lim-1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development. | Polyclonal antibodies to Xlim-1 homeodomain protein of Xenopus laevis were used to study the developmental expression pattern of this protein in Xenopus, rat and mouse. Western blotting of embryo extracts injected with different Xlim-1 constructs confirmed the specificity of the antibody. Beginning at the gastrula stag... |
8793616 | Expression of Hoxb-1 during gastrulation and segmentation stages of carp (Cyprinus carpio). | This report describes the cDNA sequence and embryonic RNA expression pattern of carp Hoxb-1. Carp Hoxb-1 is a labial-like, homeobox-containing gene of the 3' end of the Hox gene cluster. The expression pattern in carp pared to that of homologs in other vertebrates. As holds for other Hox genes, carp Hoxb-1 is expressed... |
8793617 | Xenopus oocyte maturation: cytoplasm alkalization is involved in germinal vesicle migration. | In Xenopus laevis oocytes a transient increase in intracellular pH has been reported to occur during progesterone-induced maturation. Using a cytological approach, we have systematically analyzed germinal vesicle breakdown and meiotic spindle formation in various experimental conditions either preventing or promoting p... |
8793619 | Apoptosis is involved in the disappearance of the diastemal dental primordia in mouse embryo. | Three transient dental primordia (D1, D2 and D3) exist in the upper diastema in mouse embryos and their regression is associated with the presence of cell death. In order to specify the type of cell death and its temporo-spatial distribution, staining with hematoxylin, supravital staining with Nile Blue, TUNEL method, ... |
8793618 | Delayed expression of the insulin-like growth factor I (IGF-I) gene in the XY sex-reversed female mouse ovary. | When the Y chromosome of Mus musculus domesticus (YDOM) mouse strain from Tirano (Italy) or Mus musculus poschiavinus (YPOS) from Poschiavo (Switzerland), is placed onto the C57BL/6J (B6) inbred background, the YDOM chromosome fails to induce normal testicular differentiation and instead allows development of ovaries a... |
8793620 | An identical effect mediated by thyroid deficiency or oncogene v-erbA in the chick embryo. | We have shown earlier that the association of v-myc and v-erbA (MAHEVA construct) is responsible for the appearance of a specific phenotype in chick embryos inoculated at E3. This prises rapidly growing heart rhabdomyomas (induced by v-myc alone) and within these tumors secondarily appearing cartilage nodules (Bachnou ... |
8793621 | Analysis of parent-specific gene expression in early mouse embryos and embryonic stem cells using high-resolution two-dimensional electrophoresis of proteins. | Genomic imprinting is an important genetic mechanism in mammals whereby certain genes are epigenetically modified and their expression altered according to their parental origin. The most important consequence of this is the requirement for both a maternal and a paternal genome for normal development to proceed to term... |
8793622 | Thyroid hormone regulation of germ cell-specific EF-1 alpha expression during metamorphosis of Xenopus laevis. | In situ hybridization was used to follow the distribution of the mRNAs encoding the somatic form of elongation factor 1 alpha (EF-1 alpha S) and the germinal counterparts of this factor, thesaurin a and EF-1 alpha O, throughout metamorphosis in the gonads of Xenopus laevis tadpoles. EF-1 alpha S mRNA is detected before... |
8793623 | Parthenogenetic activation of mouse oocytes using calcium ionophores and protein kinase C stimulators. | Fertilization involves the production of inositol trisphosphate and diacylglycerol with a subsequent increase in intracellular calcium concentration ([Ca2+]i) and the activation of a calcium-dependent protein kinase, the so-called protein kinase C (PKC). Methods of parthenogenetic activation have focused on this calciu... |
8793624 | A WHO Collaborative Study of Maternal Anthropometry and Pregnancy Outcomes. | To evaluate to what degree anthropometric measurements are useful and efficient in predicting maternal and fetal es in different country settings and to develop appropriate reference curves for maternal weight gain. |
8793625 | Resistance to chloroquine therapy in pregnant women with malaria parasitemia. | The objective of the study was to determine the efficacy of chloroquine in pregnant women with Plasmodium falciparum parasitemia at therapeutic doses of 25 mg/kg body weight divided over 3 days. |
8793626 | Treatment of cervical pregnancy with methotrexate. | To review our experience with early ultrasonographic diagnosis and plete medical treatment of cervical pregnancy. |
8793627 | Appendectomy in the surgical staging of ovarian carcinoma. | Extensive debulking is accepted as the primary method of operative management for carcinoma of the ovary. However, there is no consensus regarding the role of appendectomy in primary surgical treatment. The aim of this study was to assess the role of appendectomy in the surgical staging and cytoreduction of ovarian car... |
8793628 | Office hysteroscopic tubal occlusion with siloxane intratubal devices (the Ovabloc method). | To study the results of the Ovabloc method for female sterilization used in an outpatient setting. |
8793629 | Management of perineal endometriosis. | To demonstrate the appropriate diagnosis and management of perineal endometriosis. |
8793633 | ACOG technical bulletin. Sterilization. Number 222--April 1996 (replaces no. 113, February 1988). American College of Obstetricians and Gynecologists. | Sterilization provides a safe and effective contraceptive method. Both female and male sterilization have few long-term sequelae. Several new methods of transcervical sterilization are under development, but laparoscopy and minilaparotomy are likely to remain the most popular methods of female sterilization. |
8793635 | A discourse on human hair fibers and reflections on the conservation of drug molecules. | A gross discourse on human hair fibers and their formation is presented stressing the various interdisciplinary aspects, such as the morphological, biological, structural and biochemical data considered to be important in the field of hair analysis. An attempt is made to explain the incorporation of drug molecules duri... |
8793636 | Concentrations of delta 9-tetrahydrocannabinol, cocaine and 6-monoacetylmorphine in hair of drug abusers. | Hair samples taken from 850 individuals with presumed drug abuse were tested simultaneously for delta 9-tetrahydrocannabinol (THC), cocaine, heroin, the primary heroin metabolite 6-monoacetylmorphine (6-MAM) and morphine. The drugs were extracted with methanol under sonication. Compared to other extraction procedures t... |
8793637 | Population genetics of STR loci in Caucasians. | STR loci are ing increasingly important in forensic casework. In order to be used fairly and efficiently, the population genetics of these loci must be investigated and the implications for forensic inference assessed. A key population genetics parameter is the "coancestry coefficient", or FST, which is the correlation... |
8793638 | Semiparametric approach to match probability calculations using single locus probes. | A semiparametric approach to match probability calculations using single locus probes has been developed pared graphically with other standard methods by a one-sample simulation. The density functions obtained using this method are closer to the real distributions than those obtained by conventional approaches. Our met... |
8793641 | Population study of the STRs HUMTH01 (including a new variant) and HUMVWA31A in Catalonia (northeast Spain). | Allele and genotype frequencies for 2 short tandem repeat loci were determined in a population sample from Catalonia (Spain) using the polymerase chain reaction. After denaturing PAG electrophoresis, mon and one variant (13.3) alleles were identified for HUMTH01 in a sample of 234 unrelated individuals, and seven allel... |
8793639 | Failed PCR amplifications of MBP-STR alleles due to polymorphism in the primer annealing region. | The PCR-based STR system MBP-B (myelin basic protein locus B) has been reported to exhibit a high rate of mutations. Using a newly designed pair of primers we present evidence that this is due to failed amplifications caused by a polymorphism in the annealing region of the reverse primer originally designed. With the n... |
8793640 | The STR systems HumVWA and HumACTBP2 in a Hungarian population. | Allele frequencies of the Short tandem repeat systems HumVWA and HumACTBP2 were determined from 105 unrelated individuals from the area of Szeged, Hungary. A total of 8 alleles was detected for VWA, and 23 alleles were found for ACTBP2. In both systems no deviations from Hardy-Weinberg equilibrium were observed. pariso... |
8793642 | Allele detection and population study in Japanese using two STR loci (CYP19 and HUMTH01). | Allele fragments at two polymorphic short tandem repeat (STR) loci, CYP19 and HUMTH01, were simultaneously amplified in a sample of 200 unrelated Japanese individuals living in the Kanto area, including Tokyo. After electrophoresis in PAG, the new alleles 7, 10, 11, 12, and 13 were detected at the CYP19 locus in Japane... |
8793643 | The detection of picoplankton 16S rDNA in cases of drowning. | Picoplankton belonging to the Synechococcus genus in cyanobacteria (approximately 1 micron in size) are found ubiquitously in Lake Biwa, Japan. However, they could not be morphologically discriminated from other bacteria by microscopy. In this study we attempted to use picoplankton for the diagnosis of drowning by PCR ... |
8793645 | Teaching medical students by role playing: a model for integrating psychosocial issues with disease management. | Medical students on third-year rotations seem to be focused more on the particulars of disease management than on patient management. They often pay too little attention to the psychological and social needs of the patient and to the importance of working in a multidisciplinary team. The authors postulated that a model... |
8793646 | Communication, accrual to clinical trials, and the physician-patient relationship: implications for training programs. | Previous studies have demonstrated that less than 20% of fully eligible patients participate in cancer clinical trials. One of the major factors determining whether patients will be successfully accrued to trials is the quality of munication occurring between the physician and patient (and family members if present). T... |
8793647 | Oral cancer education in dental schools: survey of Texas dental students. | Senior dental students at the three Texas dental schools were surveyed about their attitudes and perceptions of their knowledge and skills in areas related to prevention, detection, and diagnosis of oral cancer, and the management of oral sequelae of cancer therapy methods. A 16-item survey was distributed to a total o... |
8793648 | Tumor board formats: "fascinating case" versus "working conference". | To test the hypothesis that a "working conference" (WC; tumor board format in which any case requiring multispecialty input is presented for discussion) was preferable to a "fascinating case" (FC; only "interesting" or "unusual" cases presented) format, tumor board format at the Portland Veterans Affairs Medical Center... |
8793649 | Cancer-risk-related health behaviors and attitudes of older workers. Working Well Research Group. | The National Cancer Institute's Working Well Trial was a randomized controlled trial of a prehensive, worksite-based cancer control intervention. |
8793650 | Attitudes about skin cancer prevention: a qualitative study. | Skin cancer represents a significant threat to the health and well-being of Americans. By engaging in both primary and secondary preventive behaviors, individuals can reduce their risks of developing skin cancer. |
8793651 | Children's return to school after treatment for cancer: study days for teachers. | As greater numbers of children return to school after treatment for cancer, their teachers need information and assurance in order to facilitate the reintegration process. |
8793652 | Use of effective feedback to facilitate adult learning. | Effective feedback plays a critical role in helping adult learners achieve their educational goals and reach their maximum potential. It should be an integral part of every adult education program. Both formal and informal feedback should be provided by teachers, based on the underpinnings of effective feedback techniq... |
8793653 | Clinical and histological features of poor prognosis in cutaneous metastatic melanomas. | Patients with melanoma metastatic to the skin show variable prognosis. Though some may survive for quite a long time, some die of disseminated disease within 1 year of removal of cutaneous metastases. The aim of this study was to find out whether there are any histological criteria indicating particular poor e. Clinica... |
8793654 | p75 nerve growth factor receptor staining helps identify desmoplastic and neurotropic melanoma. | Melanoma is a malignant tumor with a varied histologic appearance. posed of spindle cells may include desmoplastic and neurotropic melanoma. The histologic diagnosis of desmoplastic and neurotropic melanoma can be difficult. Although S100 protein stains a majority of these melanomas, the staining may be weak or focal. ... |
8793655 | Involvement of the adherens junction-actin filament system in acantholytic dyskeratosis of Hailey-Hailey disease. A histological, ultrastructural, and histochemical study of lesional and non-lesional skin. | Hailey-Hailey disease is a blistering genodermatosis that shows acantholytic dyskeratosis throughout the epidermis. The aim of our study was to investigate the involvement of adherens structures and cytofilaments in this particular type of acantholysis. Both lesional and non-lesional skin from 18 patients was studied h... |
8793656 | Vla and alpha 6 beta 4 integrin expression in neuroendocrine carcinomas of the skin (their xenografts on nude mice and a corresponding primary culture). | Immunohistological expression of VLA1-5 and alpha 6 beta 4 integrins have been studied in 21 cases of primary neuroendocrine carcinomas of the skin (NECS), three xenografts on nude mice and one NECS cell culture. The phenotypic properties of NECS cells were largely maintained in NECS grafted on athymic nude-mice and in... |
8793657 | p53 immunoreactivity in non-melanoma skin cancer from immunosuppressed and immunocompetent individuals: a comparative study of 246 tumours. | p53 immunoreactivity was examined in 132 cutaneous non-melanoma tumours from renal transplant recipients and in 114 histologically matched specimens from petent individuals. Skin lesions examined included 52 viral warts, 50 dysplastic keratoses, 51 intraepidermal carcinomas (IEC), 50 invasive squamous cell carcinomas (... |
8793658 | Intermediate- and low-molecular-weight keratin detection with the monoclonal antibody MNF116. An immunohistochemical study on 232 paraffin-embedded cutaneous lesions. | Immunohistochemical detection of certain low to intermediate molecular weight keratins often is impaired in routinely processed specimens due to masking of these antigens by formalin fixation. Despite standard enzymatic digestion, AE1:AE3 and CAM 5.2, two of the most currently utilized antikeratin antibody preparations... |
8793659 | Systemic cytokine administration alters the histology of the eruption of lymphocyte recovery. | The eruption of lymphocyte recovery occurs after marrow ablative antineoplastic chemotherapy, with the earliest reappearance of lymphocytes in the peripheral circulation. The typical histopathologic findings are not specific, consisting of a perivascular lymphocytic infiltrate in the upper dermis with mild overlying ep... |
8793660 | Perivascular mast cells in urticaria pigmentosa. | We have quantified perivascular mast cells in cases of urticaria pigmentosa, urticaria, and dermal hypersensitivity reactions. To facilitate reproducibility, the mast cells were counted for a precisely defined vessel unit. These vessel units were divided arbitrarily into those < or = 55 microns and > 55 microns in larg... |
8793661 | Skin lesions revealing neonatal acute leukemias with monocytic differentiation. A report of 3 cases. | Acute myelo-monoblastic (AMML) and acute monoblastic (AML) leukemias have a bad prognosis, especially in children when occurring in the first months of life. We report 3 cases of such leukaemias in which skin lesions preceded and revealed the leukemia. For the 3 infants, cutaneous lesions appeared about one month befor... |
8793662 | Mucinous differentiation in adnexal sweat gland tumors. | We report an eccrine acrospiroma, on the cheek of a 29-year-old female, in which the presence of abundant mucinous (goblet cell) metaplasia closely mimicked a primary mucoepidermoid carcinoma. To determine the frequency of mucinous differentiation in benign adnexal sweat gland tumors, we evaluated sixty-five cases in h... |
8793663 | Neutrophilic spongiosis in pemphigus herpetiformis. | Pemphigus herpetiformis is a rare pemphigus variant with light microscopic features that have historically been described as either "acantholytic dermatitis herpetiformis" or as "eosinophilic spongiosis in pemphigus". The clinical features of this form of pemphigus are reminiscent of dermatitis herpetiformis; however, ... |
8793664 | Pityriasis rubra pilaris with acantholysis. | Two patients developed a papulosquamous eruption in a widespread distribution which progressed with islands of sparing of uninvolved skin characteristic clinically of adult-onset pityriasis rubra pilaris (PRP). Biopsies from both patients showed multiple areas of nonfollicular and follicular suprabasilar and intra-epid... |
8793665 | Histiocytic sarcoma that mimics benign histiocytosis. | A 28-year-old man presented with a histiocytic a of a very mon origin, as it had developed for several years like a benign cutaneous histiocytosis resembling generalized eruptive histiocytoma before ing acute, with nodal and massive pulmonary involvement. Despite various chemotherapies, the patient died within 8 months... |
8793666 | Unusual features of primary dermatofibrosarcoma protuberans and its myxoid recurrence. | A case of a Protuberans (DFSP) with unusual clinical and histological features is presented. The lesion recurred one year after surgical removal and showed myxoid degeneration of the entire lesion. Only a few cases with myxoid degeneration of the entire lesion are described in the literature. We found CD 34 stain, bina... |
8793667 | An objective measurement of the anchoring strength of anagen hair in an adult with the loose anagen hair syndrome. | A 21-year-old male presented with the life-long symptom of slowly growing, easily extractable hair lacking sheath remnants. The distribution and density of all his hair regions appeared normal and there was no alopecia. A hair-pull test was painless and resulted in all hairs being removed, all in keeping with a diagnos... |
8793669 | Replacement of the ascending aorta with composite valve grafts: long term results. | Long term survival after replacement of the aortic root is improving. The mon cause of late death is progression of disease in the remaining aorta (dissection or atherosclerosis). The purpose of this study was to review our clinical experience posite graft replacement of the aortic root with special reference to long t... |
8793670 | Functional results after aortic valve repair in aortic root ectasia. | Aortic insufficiency due to dilation of the aortic root is mon finding. bined replacement of the aortic valve and the ascending aorta is regarded as standard treatment, total replacement of the proximal aorta with a tube graft and resuspension of the valve is a new alternative. |
8793671 | Aortic dissection in puerperium: a case report. | An acute type A aortic plicated by massive aortic regurgitation, was diagnosed in the case of a 32-year-old woman, thirty-three days post partum. Emergency operation (Cabrol II) was performed with an uneventful postoperative course. We draw attention to this high risk event, which is particularly apt to involve women w... |
8793672 | Systolic and diastolic mitral regurgitation in a patient with annulo-aortic ectasia demonstrated by color Doppler flow imaging. | A rare case of annulo-aortic ectasia is reported in a 65-year-old man who had aortic and mitral regurgitation during systole and diastole. He was hospitalized for further examination of the heart due to cardiomegaly and heart murmurs. Aortography revealed severe aortic regurgitation. On color Doppler flow imaging, we c... |
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