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The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689. The catalytic efficiency for thrombin cleavage at Arg-740 is greater than at either Arg-1689 or Arg-372 and influences reaction rates at these sites. Because cleavage at Arg-372 a...	[ "Arginine", "Catalysis" ]
Cells dynamically interact throughout animal development to coordinate growth and deter disease. For example, cell-cell competition weeds out aberrant cells to enforce homeostasis. In Drosophila, tumorigenic cells mutant for the cell polarity gene scribble (scrib) are actively eliminated from epithelia when surrounded ...	[ "Animals", "Cadherins" ]
Bone hemangiomas are extremely rare in the ribs, with only a handful of cases reported in the literature. A case of a rib hemangioma is presented in which the pre-resection diagnosis was an aggressive chest wall tumor. The plain film, CT, MRI and bone scan features of the lesion were reviewed with the pathological corr...	[ "Adult", "Bone Neoplasms" ]
A robust and straightforward method for on-site determination of radon-222 activity concentrations in water is presented. The methodical approach is based on the principle of liquid-gas-membrane extraction. An extraction module, which consists of hollow polypropylene fibres, allows radon stripping from the water of int...	[ "Equipment Design", "Equipment Failure Analysis" ]
The proteomic response of recombinant Escherichia coli producing human glucagon-like peptide-1 was analyzed by two-dimensional gel electrophoresis. Protein spots in two-dimensional gel could be identified by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and their expression profiles...	[ "Electrophoresis, Gel, Two-Dimensional", "Electrophoresis, Polyacrylamide Gel" ]
We recently have reported that ghrelin modulates adult hippocampal neurogenesis. However, there is a possibility that the action of ghrelin on hippocampal neurogenesis could be, in part, due to the ability of ghrelin to stimulate the GH/insulin-like growth factor (IGF)-1 axis, where both GH and IGF-1 infusions are know...	[ "Acylation", "Animals" ]
The perception of drivers regarding risk-taking behaviour is widely varied. High-risk drivers are the segment of drivers who are disproportionately represented in the majority of crashes. This study examines the typologies of drivers in risk-taking behaviour, the common high-risk driving errors (speeding, close followi...	[ "Accident Prevention", "Accidents, Traffic" ]
Vegetable consumption has been encouraged as a component of nutritional education for obese and insulin-resistant patients. However, the benefits of vegetable intake in a therapeutic diet on postprandial glycemic and lipidemic responses have not been clarified. We studied the effects of the intake of spinach, a green-l...	[ "Adult", "Blood Glucose" ]
Six hundred ninety-five mice received adeno-associated virus (AAV) vectors, mostly via portal vein injection. At necropsy, the livers were inspected for tumors, and tissue sections were prepared for histology. We observed only one tumor, a lipoma, resulting in a tumor frequency of 0.14%. This tumor contained fewer vect...	[ "Animals", "Dependovirus" ]
Body composition can be assessed in many different ways. High-end medical equipment, such as Dual-energy X-ray Absorptiometry (DXA), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) offers high-fidelity pixel/voxel-level assessment, but is prohibitive in cost. In the case of DXA and CT, the approach expos...	[ "Algorithms", "Bayes Theorem" ]
The future paths of population ageing result from specific combinations of declining fertility and increasing life expectancies in different parts of the world. Here we measure the speed of population ageing by using conventional measures and new ones that take changes in longevity into account for the world as a whole...	[ "Age Distribution", "Aged" ]
In urban environments, raccoons (Procyon lotor) may act as reservoirs for an array of pathogenic organisms, presenting spillover risks for human, domestic animal, and captive (zoo) animal populations. Over 5 yr, 159 raccoons from a high-density raccoon population in St. Louis, Missouri (USA), were surveyed for exposure...	[ "Adenoviridae", "Adenoviridae Infections" ]
BACKGROUND: The environmental contribution to autism spectrum disorders (ASD) is largely unknown, but household pesticides are receiving increased attention. We examined associations between ASD and maternally-reported use of imidacloprid, a common flea and tick treatment for pets.METHODS: Bayesian logistic models were...	[ "Animals", "Bayes Theorem" ]
SUMMARY: MASS is a command-line program to perform meta-analysis of sequencing studies by combining the score statistics from multiple studies. It implements three types of multivariate tests that encompass all commonly used association tests for rare variants. The input files can be generated from the accompanying sof...	[ "Data Interpretation, Statistical", "Genetic Variation" ]
MIF-1 (Pro-Leu-Gly-NH2), a hypothalamic tripeptide, has been demonstrated to stimulate naloxone in antagonizing the effects of opioid peptides in a number of experimental systems including enkephalin-induced analgesia in the tail-flick assay, beta-endorphin induced hypothermia and hypomotility, deprivation-induced drin...	[ "Animals", "Blood Pressure" ]
Lung cancer remains the leading cause of cancer death worldwide. Overall 5-year survival is approximately 10-15% and despite curative intent surgery, treatment failure is primarily due to recurrent disease. Conventional prognostic markers are unable to determine which patients with completely resected disease within ea...	[ "Aged", "Carcinoma, Squamous Cell" ]
Microwave-induced thermoacoustic imaging (MITAI) is an imaging technique with great potential for detecting breast cancer at early stages. Thermoacoustic imaging (TAI) combines the advantages of both microwave and ultrasound imaging techniques. In the current study, a three-dimensional novel numerical simulation of TAI...	[ "Acoustics", "Breast Neoplasms" ]
In animals, histamine inhalation is known to increase either respiratory frequency or respiratory drive by stimulation of airway vagal sensitive endings. However, it is not well known whether these changes are concomitant in man. In order to elucidate this point, we carried out the present investigation in thirty-five ...	[ "Administration, Inhalation", "Adult" ]
Masked mycotoxins are biologically modified phase II metabolites formed by plant defense mechanisms through glucosylation catalyzed by uridine diphosphate -glucosyltransferases. Most of the current reports focus on the occurrence of masked mycotoxins in Europe, America, Africa, and cover other geographic regions, e.g. ...	[ "Animals", "Food Contamination" ]
PURPOSE: To evaluate the utility of transutricular seminal vesiculoscopy as a diagnostic and therapeutic option for symptomatic midline cyst of the prostate in patients with hematospermia and symptoms associated with prostatitis.MATERIALS AND METHODS: From January 2005 to July 2013, 61 patients with symptomatic (hemato...	[ "Adult", "Aged" ]
An extracorporeal shunt circuit interposed between the left carotid artery and the left coronary ostium employs an electromagnetic flowmeter to measure coronary blood flow in the closed-chest anesthetized dog. Flow may be measured with the animal's arterial pressure as the driving force; introduction of a roller pump, ...	[ "Animals", "Assisted Circulation" ]
Central Motor Conduction Time (CMCT) was investigated in 18 patients (5 m, 13 f; age range: 11-69 yrs) with clinical and electrophysiological features of HMSN type I, using Magnetic Coil (MC) stimulation. No one exhibited clinically pyramidal signs. Brain stimulation Motor Evoked Potentials (MEPs), recorded monolateral...	[ "Adolescent", "Adult" ]
OBJECTIVE: To estimate the extent to which cervical stromal invasion would predict survival.METHODS: Cases of stage II endometrioid endometrial adenocarcinoma from three academic institutions were reviewed. A gynecologic pathologist reevaluated archived slides and measured the depth of cervical stromal invasion. Clinic...	[ "Adult", "Aged" ]
We describe a patient with juvenile levodopa-responsive Parkinsonism who reported a dramatic response to cigarette smoking with transient but marked improvement of motor symptoms associated with oculogyric crises and psychotic behavior. His beta-CIT single-photon emission computed tomography scan showed a complete abse...	[ "Adult", "Humans" ]
The recombinant heavy chain myosin of Brugia malayi (Bm-Myo) has earlier been reported as a potent vaccine candidate in our lab. Subsequently, we further enhanced its efficacy employing heterologous DNA prime/protein boost (Myo-pcD+Bm-Myo) immunization approach that produced superior immune-protection than protein or D...	[ "Animals", "Antibodies, Helminth" ]
To determine the prevalence of cervical human papillomavirus (HPV) infection and risk factors in young women from Brazil, Canada, and the USA. Cross-sectional study in 3204 healthy women, aged 15 to 25 years. Cervical samples were collected for cytology and for HPV DNA detection (SPF 10-LiPA 25 system). Serum samples w...	[ "Adolescent", "Adult" ]
A non-aqueous capillary electrophoresis (NACE) method for quantifying the seven crocin metabolites that are the major biologically active ingredients of saffron was developed. Separation is done by using a fused silica capillary filled with a 12.5 mM H3BO3/37.5 mM sodium tetraborate methanolic solution as background el...	[ "Carotenoids", "Crocus" ]
A 3' -phosphoadenosine 5' -phosphosulfate (PAPS):chondroitin sulfate sulfotransferase from chicken embryo epiphyseal cartilage, which was partially purified, exhibited a molecular mass of 150 kDa. The enzymatic sulfation of totally desulfated chondroitin was activated up to 12-fold by protamine while the sulfation of p...	[ "Adenine Nucleotides", "Animals" ]
Subcutaneous injections of a 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), in monkeys induced distinct behavioural changes characterized by head weaving, hindlimb extension and upper limb fluttering. The effects were dose-dependent and were similar to the 5-HT syndrome induced in rats by ...	[ "8-Hydroxy-2-(di-n-propylamino)tetralin", "Animals" ]
BACKGROUND: Peptic ulcer disease is a common complication among renal transplant recipients and causes significant morbidity and mortality.METHODS: From 1990 through 2000, 465 renal transplant patients were followed-up in our institute. Most patients received corticosteroids and cyclosporine-based immunosuppressive reg...	[ "Adolescent", "Adult" ]
The aim of the present study is to identify the optimal anticancer agents for use in combination with gene therapy using wild-type (wt) p53 gene transfer. We used adenoviral vectors expressing human wt p53 (AdCAp53) and investigated the effects of wt p53 gene transfer in combination with 12 anticancer agents on a human...	[ "Adenoviridae", "Animals" ]
This article presents a comparative study among people with cerebral palsy and healthy controls, of various ages, using a Brain-computer Interface (BCI) device. The research is qualitative in its approach. Researchers worked with Observational Case Studies. People with cerebral palsy and healthy controls were evaluated...	[ "Brain-Computer Interfaces", "Brazil" ]
A study was conducted to determine the degree to which social support and personality predict the use of reasoning and aggression by adolescents to resolve interpersonal conflict. Although all adolescents appeared to use reasoning to resolve conflict, those with less social support and those exhibiting a forceful perso...	[ "Adolescent", "Aggression" ]
BACKGROUND: Catecholamines are significantly elevated in inflammatory responses and play a regulatory role in sepsis. Nitric oxide (NO), also a key inflammatory mediator in sepsis, is produced in large amounts by the inducible nitric oxide synthase (iNOS) in the liver. The purpose of this study was to test the hypothes...	[ "8-Bromo Cyclic Adenosine Monophosphate", "Adenoviridae" ]
We have developed a restriction enzyme-mediated insertional mutagenesis (REMI) system for the maize pathogen Colletotrichum graminicola. In this report, we demonstrate the utility of a REMI-based mutagenesis approach to identify novel pathogenicity genes. Use of REMI increased transformation efficiency by as much as 27...	[ "Blotting, Southern", "Colletotrichum" ]
The internationalization of Chinese acupuncture-moxibustion is inevitably accompanied by the localization of acupuncture-moxibustion. The localization of acupuncture-moxibustion will inevitably promote the diversified development of acupuncture-moxibustion technique and theory, which fully demonstrates the openness of ...	[ "Acupuncture Therapy", "Moxibustion" ]
OBJECTIVE: To evaluate glycemic variation and hypoglycemia in patients with well-controlled type 1 diabetes receiving multiple daily insulin injections during glargine and Ultralente use as basal insulin in a clinical trial.METHODS: Twenty-two patients (12 men and 10 women; median age, 43 years), with a hemoglobin A1c ...	[ "Adult", "Aged" ]
16S rRNA gene sequences were determined for Eubacterium exiguum and Peptostreptococcus heliotrinreducens. These species were found to be closely related and, together with Eubacterium lentum, to constitute a branch of the Coriobacteriaceae. Two new genera are proposed on the basis of phenotypic characteristics and 16S ...	[ "Base Composition", "DNA, Bacterial" ]
President Trump and his administration have been regarded by news outlets and scholars as one of the most hostile administrations towards scientists and their work. However, no study to-date has empirically measured how federal scientists perceive the Trump administration with respect to their scientific work. In 2018,...	[ "Federal Government", "Humans" ]
Many macrofungus sclerotia are well-known medicinal herbs, health food and nutritional supplements. However, the prevalent adulterant commercial products are major hindrances to their incorporation into mainstream medical use in many countries. The mushroom sclerotia of Lignosus rhinocerotis, Poria cocos, Polyporus umb...	[ "Agaricales", "Medicine, Chinese Traditional" ]
A study was made of the possibility of forming nicotine addiction in laboratory rats and using it as the basis for the design of experimental nicotine toxicomania. Experiments were carried out on 56 rats placed in individual cages with a possibility of free choice between water and 0.005% nicotine solution for 2 to 4 m...	[ "Animals", "Cocaine" ]
Benign migratory stomatitis is a relatively rare entity, but because of its benign nature and clinical characteristics, it should be easily recognized by the general practitioner. Biopsy is usually not indicated and treatment consists of reassuring the patient that the lesions are benign even though they may disappear,...	[ "Diagnosis, Differential", "Erythema" ]
Extemporaneous drug formulation is essential to provide optimal pharmaceutical care to veterinary patients. The need for this is exacerbated by the fact that commercially produced veterinary-specific products, without a human indication, require specialty veterinary manufacturing facilities and a new animal drug applic...	[ "Administration, Oral", "Animals" ]
PURPOSE: Intravitreal injection of conbercept (IVC) is the latest applied treatment that could be used in retinopathy of prematurity (ROP) patients. The structural outcomes and recurrence of ROP among patients treated with IVC or intravitreal injection of ranibizumab (IVR) were compared.METHODS: A consecutive case seri...	[ "Female", "Humans" ]
Ionizing radiation induces a diverse spectrum of DNA lesions, including strand breaks and oxidized bases. In mammalian cells, ionizing radiation-induced lesions are targets of non-homologous end joining, homologous recombination, and base excision repair. In vitro assays show a potential involvement of DNA polymerase l...	[ "Animals", "Camptothecin" ]
Bilirubin, an abundant pigment that causes jaundice, has long lacked any clear physiologic role. It arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of heme oxygenase activity. Bilirubin is a potent antioxidant that we show can protect cells from a 10,000-fold excess of H2O2. We report t...	[ "Antioxidants", "Bilirubin" ]
Efficient and tunable absorption is essential for a variety of applications, such as designing controlled-emissivity surfaces for thermophotovoltaic devices, tailoring an infrared spectrum for controlled thermal dissipation and producing detector elements for imaging. Metamaterials based on metallic elements are partic...	[ "Absorption", "Colloids" ]
Addition of thenoyltrifluoracetone to mitochondria oxidizing NAD-dependent substrates induced lipid peroxidation and uncoupling of oxidative phosphorylation. Butylated hydroxytoluene, an antioxidant, prevented accumulation of lipid peroxidation products but failed to prevent deenergization of the mitochondria.	[ "Adenosine Diphosphate", "Animals" ]
BACKGROUND AND OBJECTIVE: In coupling laser with micromanipulator through fiberoptics, the resulting diameter of the spot is limited by the laws of geometrical optics, because of the high numerical aperture (N.A.) of fiberoptic radiation. A new method for the reduction of spot size diameter is suggested.STUDY DESIGN/MA...	[ "Algorithms", "Equipment Design" ]
One hundred psychiatric patients seen for the first time on a private basis received a research interview that allowed a study of demographic and clinical characteristics. Eighty-five had a discrete psychiatric disorder and fifty were suffering affective disorders. Most sought psychiatric attention because of a situati...	[ "Adult", "Emergencies" ]
BACKGROUND AND OBJECTIVE: To illustrate artifacts that may be encountered during measurement of the peripapillary retinal nerve fiber layer (RNFL) using scanning laser polarimetry (SLP).PATIENTS AND METHODS: A total of 426 patients with a variety of ocular diagnoses underwent RNFL measurements using SLP from June 1996 ...	[ "Aged", "Artifacts" ]
OBJECTIVE: To investigate the potential efficacy of panaxadiol saponins component (PDS-C), a biologically active fraction isolated from total ginsenosides, to reverse chemotherapy-induced myelosuppression and pancytopenia caused by cyclophamide (CTX).METHODS: Mice with myelosuppression induced by CTX were treated with ...	[ "Animals", "Antineoplastic Agents" ]
The K-Cl cotransporter KCC2 plays a crucial role in neuronal chloride regulation. In mature central neurons, KCC2 is responsible for the low intracellular Cl(-) concentration ([Cl(-)](i)) that forms the basis for hyperpolarizing GABA(A) receptor-mediated responses. Fast changes in KCC2 function and expression have been...	[ "Action Potentials", "Analysis of Variance" ]
Temporomandibular joint disorders (TMD) affect the joint, the masticatory muscles, or are expressed as a clinical combination of these two factors. The aims of this study were to: (i) identify the clinical and psychosocial factors that aid in the diagnosis and classification of acute and chronic TMD, (ii) determine spe...	[ "Acute Disease", "Adolescent" ]
This paper concludes a series on the findings from a study on the emerging role of nurse teachers in Project 2000 programmes. The various aspects of the study, including the literature review and methodology, have been previously discussed (Crotty & Butterworth 1992, Crotty 1992, Crotty 1993a,b,c,d). This paper highlig...	[ "Delphi Technique", "Education, Nursing" ]
Targeting of the endothelial inflammatory adhesion molecule E-selectin by magnetic resonance imaging (MRI) was performed with a superparamagnetic contrast agent in the context of in vitro and in vivo models of inflammation. The specific contrast agent was obtained by grafting a synthetic mimetic of sialyl Lewis(x) (sLe...	[ "Animals", "Cells, Cultured" ]
BACKGROUND: Left atrial (LA) remodeling is associated with structural, electric, and metabolic LA changes. Integrated evaluation of these features in vivo is lacking.METHODS: Patients undergoing 18F-fluorodeoxyglucose (FDG) PET-CT during a hyperinsulinemic-euglycemic clamp were classified into sinus rhythm (SR), paroxy...	[ "Aged", "Aged, 80 and over" ]
Sympathetic overactivity is associated with hyperhidrosis and cardiovascular diseases. Endoscopic thoracic sympathectomy (ETS) is a treatment for hyperhidrosis. We aimed to compare the risk for cardiovascular events between individuals with and without hyperhidrosis and investigate the effects of ETS on cardiovascular ...	[ "Adolescent", "Adult" ]
GCN4 is a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae whose expression is regulated by amino-acid availability at the translational level. GCD1 and GCD2 are negative regulators required for the repression of GCN4 translation under nonstarvation conditions that is mediated by u...	[ "Amino Acids", "Animals" ]
Specific immunotherapy (SIT) or allergenic desensitization would be the only treatment capable to change the natural history of the atopic march for children. SIT has shown numerous proofs of efficacy in allergic asthma particularly in improving clinical and medication scores. It could also have the capacity to prevent...	[ "Asthma", "Child" ]
An antiserum with allotypic specificity for mouse gamma(2a)-globulins was prepared in a rabbit by injection of 7S gamma(2)-globulin of C(57)BL/6 mice. The antibody reacted with an isoantigen in the 7S gamma(2)-globulins of normal serum of mouse strains belonging to the lg-1(b) allotype class (C(57)BL/6, C(57)BL/10, and...	[ "Animals", "Antigen-Antibody Reactions" ]
The efficacy of stem cell-based bone tissue engineering has been hampered by cell death and limited fate control. A smart cell culture system with the capability of sequentially delivering multiple factors in specific growth stages, like the mechanism of the natural extracellular matrix modulating tissue formation, is ...	[ "Alginic Acid", "Animals" ]
Polyanions based on poly(methyl vinyl ether-alt-maleic acid) were investigated as materials for cell encapsulation. These water-soluble polyanions having molecular masses ranging from 20 to 1980 kDa were prepared by functionalization of poly(methyl vinyl ether-alt-maleic anhydride) with 5-aminofluorescein and/or á-meth...	[ "Alginates", "Animals" ]
INTRODUCTION: Multimorbidity has been linked to elevated healthcare utilization and previous studies have found that socioeconomic status is an important factor associated with multimorbidity. Nonetheless, little is known regarding the impact of multimorbidity and socioeconomic status on healthcare costs and whether in...	[ "Adult", "Aged" ]
The jaw bones are the most common sites for epithelial cysts and tumors in the human skeleton due to their close relationship to the tooth and odontogenesis. Most of these cysts and tumors have in common an origin from the tissues of tooth formation and constitute a very diverse group of lesions that reflects the compl...	[ "Ameloblastoma", "Humans" ]
An effective and inexpensive method is developed to fabricate periodic arrays by sacrificial colloidal monolayer template route by chemical deposition and further physical deposition. By a colloidal template induced precursor solution dipping strategy, different periodic arrays of semi-hollow sphere array, inverse opal...	[ "Colloids", "Gold" ]
OBJECTIVES: Extensive skeletal muscle accumulation (ESMA) of F-FDG adversely affects the visual interpretation of F-FDG PET/computed tomography (CT) images. We mainly investigated factors related to ESMA that are based on food compositions.METHODS: From January 2018 to June 2018, a total of 5554 patients underwent F-FD...	[ "Biological Transport", "Dietary Carbohydrates" ]
In performing our experiment, impaired autophagy increased hepatocellular damage during the reperfusion period. It was demonstrated by the effect of blocking autophagy using bafilomycin A1 or knocking Atg5 gene out reduces the anti-apoptotic effect of Stat3. Here we focus on the role of signal transducer and activator ...	[ "Animals", "Apoptosis" ]
UNLABELLED: We have recently completed a large 6-(18)F-fluoro-L-DOPA ((18)F-DOPA) PET study comparing rates of loss of dopamine terminal function in Parkinson's disease (PD) patients taking either the dopamine agonist ropinirole or L-DOPA. This trial involved a "distributed acquisition/centralized analysis" method, in ...	[ "Algorithms", "Antiparkinson Agents" ]
The power of the two-experimental arm trial depends on three choices: (1) when one arm is dropped (if at all); (2) the final testing procedure, assuming no dropping; and (3) the sampling ratio for the three arms. Multiple-arm designs require critical values which were calculated using Mathematica. Power calculations we...	[ "Abciximab", "Angioplasty, Balloon" ]
In the absence of liver biopsy and transient elastography (TE), aspartate aminotransferase to platelet ratio (APRI), fibrosis-4 score (FIB-4), and gammaglutamyl transpeptidase to platelet ratio (GPR) are simple and inexpensive methods for the detection of liver fibrosis.AIMS: We compared the performance of APRI, FIB-4,...	[ "Adult", "Aspartate Aminotransferases" ]
Although there are multiple pathways to successful aging, little is known of what it means to age successfully among black women. There is a growing body of literature suggesting that black women experience a number of social challenges (sexism and racism) that may present as barriers to aging successfully. Applying as...	[ "Adaptation, Psychological", "Adult" ]
We report a 49-year-old female who had circumferential urethral diverticulum. She was admitted to our department for urinary retention. A cystic lesion surrounding the urethra had been detected by magnetic resonance imaging. We diagnosed the lesion as a urethral diverticulum after injecting dye to the cystic mass from ...	[ "Coloring Agents", "Diagnostic Imaging" ]
Vertebrates diverged from other chordates ~500 Myr ago and experienced successful innovations and adaptations, but the genomic basis underlying vertebrate origins are not fully understood. Here we suggest, through comparison with multiple lancelet (amphioxus) genomes, that ancient vertebrates experienced high rates of ...	[ "Adaptation, Physiological", "Animals" ]
Choroideremia is a progressive tapetochoroidal dystrophy with X-linked transmission leading frequently to blindness in affected males. The choroideremia-locus (TCD) has recently been assigned to the long arm of the X chromosome by linkage to polymorphic DNA markers. In order to further define the location of the gene d...	[ "Choroid", "Chromosome Mapping" ]
Studies of physicians' attitudes and knowledge of the acquired immunodeficiency syndrome (AIDS) and the clinical precautions they take against exposure to the human immunodeficiency virus (HIV) have focused on urban physicians. To determine rural physicians' knowledge and attitudes about AIDS, a questionnaire was maile...	[ "Acquired Immunodeficiency Syndrome", "Attitude of Health Personnel" ]
BACKGROUND: There is little published evidence that any aspect of vocational training for general practice improves the quality of care provided by general practitioners (GPs).AIM: To investigate whether aspects of education and vocational training predict whether GPs provide intrapartum care.METHOD: A five-year prospe...	[ "Cohort Studies", "Delivery, Obstetric" ]
OBJECTIVE: This paper reflects on the collaborative research relationship between university and community researchers. It identifies emergent themes expressed in the words of researchers and recommends strategies to assist with other research collaborations.CONCLUSIONS: Emergent themes included: Initial reticence by c...	[ "Australia", "Community-Institutional Relations" ]
A three-stage context amplification model was tested with a sample of 345 African-American parent-child dyads. The model combined the conceptual structure of stress generation with recent findings regarding genetic susceptibility. Because the 7R + allele of the dopamine transporter (DRD4) has the potential to enhance c...	[ "African Americans", "Alleles" ]
Renal cell carcinoma is known to invade the inferior vena cava and may extend its entire length. Profound hypothermic circulatory arrest has been demonstrated to be a very effective technique to facilitate removal of tumor thrombus from the cava while limiting the amount of blood loss. We describe an innovative method ...	[ "Bronchoscopes", "Carcinoma, Renal Cell" ]
Mycobacterium abscessus and Kocuria species are rare causes of infections in humans. Endocarditis by these agents has been reported in only 11 cases. M. abscessus is a particularly resistant organism and treatment requires the association of antibiotics for a prolonged period of time. We report a case of native mitral ...	[ "Actinomycetales Infections", "Endocarditis, Bacterial" ]
Though the serum total amylase test has been used for the diagnosis of pancreatitis for over 50 years, both its clinical sensitivity and specificity are far from perfect. We first present the results of serial serum total amylase, pancreatic isoamylase, lipase, and immunoreactive trypsin tests in nine patients during t...	[ "Abdomen", "Amylases" ]
A prospective study evaluated the utility of renal computed tomography (CT) and ultrasonography in 35 patients hospitalized for treatment of urinary tract infection. Renal computed tomograms were abnormal in 18 of 28 patients with acute pyelonephritis and three of four patients with urosepsis, showing findings consiste...	[ "Abscess", "Adult" ]
1. Slow inward and outward after-currents follow action potentials in the bursting pacemaker neurone, R 15, of Aplysia californica. These experiments were performed to examine the role of axo-dendritic calcium influx in activating these after currents. 2. Depolarizing voltage-clamp commands issued at the soma were used...	[ "Action Potentials", "Animals" ]
Previously, we reported that repeated oral administration of etoposide (ETP) activates the ezrin/radixin/moesin (ERM) scaffold proteins for P-glycoprotein (P-gp) via Ras homolog gene family member A (RhoA)/Rho-associated coiled-coil containing protein kinase (ROCK) signaling, leading to increased ileal P-gp expression....	[ "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine", "ATP Binding Cassette Transporter, Subfamily B" ]
In summary, therefore, to effectively apply invasive methods and beneficially use data derived from these procedures, it is essential that physicians have an understanding of the pathophysiology of ischemic heart disease and power failure, and of other situations in cardiology including the management of the complex pr...	[ "Acute Disease", "Blood Gas Analysis" ]
Microscopy of the serial block-sections of the entire bronchial tree of all the resected specimens of roentgenographically occult bronchogenic carcinoma revealed new findings with respect to the histological patterns of longitudinal growth within the bronchial wall. Twenty-seven lesions which were non-polypoid on gross...	[ "Bronchi", "Carcinoma, Bronchogenic" ]
BACKGROUND: The study was designed to analyze the underlying relationship between psychiatric comorbidities and postoperative outcomes in patients undergoing primary total knee arthroplasty (TKA).METHODS: We used the National Inpatient Sample data from 2002 to 2014. On the basis of the International Classification of D...	[ "Adult", "Aged" ]
The correlation of three colorimetric oxytocinase determination methods used in clinics was compared and assessed. It was found that the new methods, the method of Kleiner and Brounet-Yager, and that of Usategui-Gomez et al., show a high correlation with respect to the Tuppy and Nesvadba method (modified by Klimek) the...	[ "Aminopeptidases", "Colorimetry" ]
INTRODUCTION: Using numerical simulations, we predict that nonsustained reentry occurs following a strong, premature stimulus through a unipolar electrode.METHODS AND RESULTS: Our simulations were based on the bidomain model of cardiac tissue, and the active membrane properties were represented by the Beeler-Reuter mod...	[ "Computer Simulation", "Electric Conductivity" ]
Of 97 nondirected T4 thymidylate synthase-defective (td) mutations, 27 were mapped to the intron of the split td gene. Clustering of these intron mutations defined two domains that are functional in splicing, each within approximately 220 residues of the respective splice sites. Two selected mutations, tdN57 and tdN47,...	[ "Base Sequence", "Chromosome Mapping" ]
Insoluble BaSO4 scale is a costly and time-consuming problem in the petroleum industry. Clearance of BaSO4-impeded pipelines requires chelating agents that can efficiently bind Ba2+, the largest nonradioactive +2 metal ion. Due to the poor affinity of currently available chelating agents for Ba2+, however, the dissolut...	[ "Barium", "Barium Sulfate" ]
Therapeutic glycoproteins have played a major role in the commercial success of biotechnology in the post-genomic era. But isolating recombinant mammalian cell lines for large-scale production remains costly and time-consuming, due to substantial variation and unpredictable stability of expression amongst transfected c...	[ "Animals", "CHO Cells" ]
Microbiological and biochemical parameters of lactic acid bacterial lyophilized concentrates obtained by continous cultivation were investigated during their storage at 3 to 5 degrees C. Under these conditions lyophilized bacterial concentrates retained high activity for three months and after six months their cell sur...	[ "Bacteria", "Freeze Drying" ]
Lesions of distal aortic arch and proximal descending thoracic aorta require a posterolateral thoracotomy approach and total circulatory arrest. Retrograde cerebral perfusion through the superior vena cava is technically difficult in such situations. We describe a simplified technique for delivery of retrograde cerebra...	[ "Adult", "Aorta, Thoracic" ]
BACKGROUND: Perioperatively, patients' hemodynamics are modulated predominantly by intravenous fluid administration and vasoactive pharmacological support. Vasopressor agents are suspected to be detrimental on free flap survival by the cause of vasoconstriction of the pedicle with consecutive reduced overall flap perfu...	[ "Epigastric Arteries", "Female" ]
Personal computers have become common-place in physicians' practices and their use in cardiac pacing for programming and follow-up is increasing. The most commonly used media for mass data storage are ferromagnetic. That the toroidal and bar magnets used to activate reed switches pose a threat to such data is well know...	[ "Compact Disks", "Computer Storage Devices" ]
Two techniques to separate the lower incisors prior to mandibular symphyseal distraction osteogenesis (MSDO) were evaluated with respect to avoiding tooth damage.METHODS: Fifty patients (20.2 ± 7.0 years) requiring MSDO were treated with a tooth-borne appliance by utilizing two preoperative protocols to separate the ce...	[ "Adolescent", "Adult" ]
Importance: A physician's prior experience caring for a patient may be associated with patient outcomes and care patterns during and after hospitalization.Objective: To examine differences in the use of health care resources and outcomes among hospitalized patients cared for by hospitalists, their own primary care phys...	[ "Female", "General Practitioners" ]
Nicotinic stimulation and high K+ depolarization of bovine chromaffin cells cause disassembly of cortical filamentous actin networks. Previous work from our laboratory has demonstrated that disassembly of actin filaments is Ca(2+)-dependent, precedes exocytosis and occurs in cortical areas of low cytoplasmic viscosity ...	[ "Actins", "Adrenal Medulla" ]

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PubMed Multilabel

PubMed abstract multilabel classification. Only the first two labels are included. Original source

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