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yesno | Should Lubeluzole be used for treatment of ischemic stroke? | ['no'] | [
"no"
] | ['No. Lubeluzole failed to consistently show an efficacy in the treatment of acute stroke and should not be used.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/29550817",
"http://www.ncbi.nlm.nih.gov/pubmed/28939972",
"http://www.ncbi.nlm.nih.gov/pubmed/8553408",
"http://www.ncbi.nlm.nih.gov/pubmed/11869612",
"http://www.ncbi.nlm.nih.gov/pubmed/11062273",
"http://www.ncbi.nlm.nih.gov/pubmed/12038658",
"http://www.ncbi.nlm.ni... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/28939972",
"endSection": "abstract",
"offsetInBeginSection": 729,
"offsetInEndSection": 870,
"text": "Lubeluzole showed promising neuroprotective effects in animal stroke models, but failed to show benefits in acut... | 11 | BioASQ-training11b | null | null | 5e44caaf48dab47f26000024 | 0 |
yesno | Are integrins part of the extracellular matrix? | ['yes'] | [
"yes"
] | ['Yes, \tintegrins are a central family of extracellular matrix receptors.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/26029690",
"http://www.ncbi.nlm.nih.gov/pubmed/26067407",
"http://www.ncbi.nlm.nih.gov/pubmed/26096733",
"http://www.ncbi.nlm.nih.gov/pubmed/26089687",
"http://www.ncbi.nlm.nih.gov/pubmed/25605337",
"http://www.ncbi.nlm.nih.gov/pubmed/25759527",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/26029690",
"endSection": "abstract",
"offsetInBeginSection": 314,
"offsetInEndSection": 451,
"text": "Several constituents of the ECM provide adhesive cues, which serve as binding sites for cell trans-membrane rece... | 5 | BioASQ-training5b | [] | [] | 56e83a2342442bac75000001 | 1 |
yesno | Is Baloxavir effective for influenza? | ['yes'] | [
"yes"
] | ['Yes. Baloxavir is approved for influenza A or B virus infections.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/30395523",
"http://www.ncbi.nlm.nih.gov/pubmed/30316915",
"http://www.ncbi.nlm.nih.gov/pubmed/29623652",
"http://www.ncbi.nlm.nih.gov/pubmed/30184455",
"http://www.ncbi.nlm.nih.gov/pubmed/30476172",
"http://www.ncbi.nlm.nih.gov/pubmed/30396860",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/29623652",
"endSection": "abstract",
"offsetInBeginSection": 0,
"offsetInEndSection": 358,
"text": "Baloxavir marboxil (Xofluza™; baloxavir) is an oral cap-dependent endonuclease inhibitor that has been developed b... | 11 | BioASQ-training11b | null | null | 5c58a74e86df2b917400000d | 2 |
yesno | Are there any digital biomarkers for Duchenne Muscular Dystrophy? | ['yes'] | [
"yes"
] | ['Yes, the KineDMD ethomic biomarker is a digital biomarker for Duchenne Muscular Dystrophy.', 'Yes, wearable full-body motion tracking of activities of daily living is a digital biomarker for Duchenne Muscular Dystrophy that can predict disease trajectory', "Yes, there is a digital biomarker for Duchenne Muscular Dyst... | [
"http://www.ncbi.nlm.nih.gov/pubmed/36658421"
] | [
{
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36658421",
"endSection": "title",
"offsetInBeginSection": 0,
"offsetInEndSection": 124,
"text": "Wearable full-body motion tracking of activities of daily living predicts disease trajectory in Duchenne muscular dystro... | 13 | BioASQ-training13b | null | null | 66302174187cba990d00002e | 3 |
yesno | Are sleep apnea and snoring associated with cardiac arrhythmias? | ['yes'] | [
"yes"
] | ['Evidence supports a causal association of sleep apnea with the incidence and morbidity of hypertension, coronary heart disease, arrhythmia, heart failure, and stroke.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/28209226",
"http://www.ncbi.nlm.nih.gov/pubmed/16293956",
"http://www.ncbi.nlm.nih.gov/pubmed/28992834",
"http://www.ncbi.nlm.nih.gov/pubmed/3542725",
"http://www.ncbi.nlm.nih.gov/pubmed/20351955",
"http://www.ncbi.nlm.nih.gov/pubmed/331948",
"http://www.ncbi.nlm.nih.... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/28040290",
"endSection": "abstract",
"offsetInBeginSection": 0,
"offsetInEndSection": 244,
"text": "Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiov... | 11 | BioASQ-training11b | [
"http://www.disease-ontology.org/api/metadata/DOID:0050847",
"https://meshb.nlm.nih.gov/record/ui?ui=D012891",
"http://www.disease-ontology.org/api/metadata/DOID:9220",
"https://meshb.nlm.nih.gov/record/ui?ui=D012913",
"http://www.disease-ontology.org/api/metadata/DOID:0050848",
"https://meshb.nlm.nih.gov... | null | 5a981dd0fcd1d6a10c00002e | 5 |
yesno | Is Vitamin D deficiency associated with sepsis mortality? | ['yes'] | [
"yes"
] | ['Yes, Vitamin D deficiency is associated with increased mortality in patients with septic shock.', 'Yes, vitamin D deficiency is associated with mortality in sepsis patients.', 'Yes, vitamin D deficiency is associated with sepsis mortality in patients with severe vitamin D deficiency.', 'Yes, Vitamin D deficiency is p... | [
"http://www.ncbi.nlm.nih.gov/pubmed/36265656"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/36265656",
"endSection": "abstract",
"offsetInBeginSection": 1504,
"offsetInEndSection": 1619,
"text": "Vitamin D deficiency was prevalent in patients with septic shock visiting the ED and was associated with morta... | 13 | BioASQ-training13b | null | null | 662f401b187cba990d00000e | 6 |
yesno | Is vemurafenib used for thyroid cancer? | ['yes'] | [
"yes"
] | ['Yes. Vemurafenib, a selective BRAF inhibitor, appears to have promising clinical activity in patients with papillary thyroid cancer (PTC) harboring the BRAF(V600E) mutation.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/27460442",
"http://www.ncbi.nlm.nih.gov/pubmed/27554612",
"http://www.ncbi.nlm.nih.gov/pubmed/27754804",
"http://www.ncbi.nlm.nih.gov/pubmed/24987354",
"http://www.ncbi.nlm.nih.gov/pubmed/23489023",
"http://www.ncbi.nlm.nih.gov/pubmed/26751190",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/27460442",
"endSection": "title",
"offsetInBeginSection": 0,
"offsetInEndSection": 193,
"text": "Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radi... | 6 | BioASQ-training6b | [
"http://www.disease-ontology.org/api/metadata/DOID:3963",
"http://www.disease-ontology.org/api/metadata/DOID:1781",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013964"
] | [
{
"o": "VEMURAFENIB",
"p": "http://www.w3.org/2000/01/rdf-schema#label",
"s": "http://linkedlifedata.com/resource/rxnorm/id/1147220"
},
{
"o": "http://linkedlifedata.com/resource/umls/label/A20020623",
"p": "http://www.w3.org/2008/05/skos-xl#altLabel",
"s": "http://linkedlifedata.com/res... | 58848ea5e56acf517600000e | 7 |
yesno | Has the proteome of mice hippocampus been analysed? | ['yes'] | [
"yes"
] | ['Yes, numerous proteomic studies of mice hippcampi has been performed.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/26549202",
"http://www.ncbi.nlm.nih.gov/pubmed/28775826",
"http://www.ncbi.nlm.nih.gov/pubmed/26977433",
"http://www.ncbi.nlm.nih.gov/pubmed/27378549",
"http://www.ncbi.nlm.nih.gov/pubmed/27001617"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/26549202",
"endSection": "abstract",
"offsetInBeginSection": 738,
"offsetInEndSection": 972,
"text": "We employed a discovery-based proteomic approach in subcellular fractions of hippocampal tissue from chronic int... | 11 | BioASQ-training11b | null | null | 5a8881118cb19eca6b000006 | 8 |
yesno | Is cytisine superior to nicotine replacement therapy for smoking cessation? | ['yes'] | [
"yes"
] | ['Yes, one clinical trial that directly compared smoking cessation rates with cytisine versus nicotine replacement therapy reported that cytisine was superior to nicotine-replacement therapy in helping smokers quit smoking, but it was associated with a higher frequency of self-reported adverse events.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/21328282",
"http://www.ncbi.nlm.nih.gov/pubmed/21385905",
"http://www.ncbi.nlm.nih.gov/pubmed/22104038",
"http://www.ncbi.nlm.nih.gov/pubmed/22513936",
"http://www.ncbi.nlm.nih.gov/pubmed/25517706",
"http://www.ncbi.nlm.nih.gov/pubmed/24831822",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/25517706",
"endSection": "abstract",
"offsetInBeginSection": 1245,
"offsetInEndSection": 1541,
"text": "The effectiveness of cytisine for continuous abstinence was superior to that of nicotine-replacement therapy a... | 5 | BioASQ-training5b | [
"http://www.biosemantics.org/jochem#4251343",
"http://www.biosemantics.org/jochem#4273701"
] | [] | 54d77f0e3706e8952800001b | 10 |
yesno | Is Stat4 a transcription factor? | ['yes'] | [
"yes"
] | ['Yes, Stat4 is a transcription factor.\nStat4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm. STAT4 regulates various genes expression as a transcription factor after it is phosphorylated, dimerizes and translocates to the nucleus.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/25178516",
"http://www.ncbi.nlm.nih.gov/pubmed/25829541",
"http://www.ncbi.nlm.nih.gov/pubmed/25798064",
"http://www.ncbi.nlm.nih.gov/pubmed/25852285"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/25829541",
"endSection": "abstract",
"offsetInBeginSection": 713,
"offsetInEndSection": 750,
"text": "transcription factors T-bet and STAT4"
},
{
"beginSection": "abstract",
"document": "http://www.ncbi... | 6 | BioASQ-training6b | null | null | 58bc58c302b8c60953000001 | 11 |
yesno | Can chronological age be predicted by measuring telomere length? | ['no'] | [
"no"
] | ['No, telomere length measurement by real-time quantitative PCR cannot be used to predict age of a person, due to the presence of large inter-individual variations in telomere lengths.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/23167566",
"http://www.ncbi.nlm.nih.gov/pubmed/18378481"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/18378481",
"endSection": "abstract",
"offsetInBeginSection": 356,
"offsetInEndSection": 558,
"text": "Human somatic cells gradually lose telomeric repeats with age. This study investigated if one could use a correl... | 5 | BioASQ-training5b | [] | [] | 56d34fbcf22319765a000009 | 12 |
yesno | Was ALVAC-HIV effective for HIV prevention in the HVTN 702 trial? | ['no'] | [
"no"
] | ['No. The ALVAC-gp120 regimen did not prevent HIV-1 infection among participants in South Africa despite previous evidence of immunogenicity'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/33761206",
"http://www.ncbi.nlm.nih.gov/pubmed/34029515",
"http://www.ncbi.nlm.nih.gov/pubmed/32554928"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/33761206",
"endSection": "abstract",
"offsetInBeginSection": 1258,
"offsetInEndSection": 1662,
"text": "During the 24-month follow-up, HIV-1 infection was diagnosed in 138 participants in the vaccine group and in 1... | 11 | BioASQ-training11b | null | null | 61faa3bac9dfcb9c0900000b | 13 |
yesno | Can Enlimomab improve stroke outcomes? | ['no'] | [
"no"
] | ['No. Anti-ICAM therapy with enlimomab is not an effective treatment for ischemic stroke and, indeed, may significantly worsen stroke outcome.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/19849665",
"http://www.ncbi.nlm.nih.gov/pubmed/12365824",
"http://www.ncbi.nlm.nih.gov/pubmed/9693236",
"http://www.ncbi.nlm.nih.gov/pubmed/12038658",
"http://www.ncbi.nlm.nih.gov/pubmed/9744839",
"http://www.ncbi.nlm.nih.gov/pubmed/11673584",
"http://www.ncbi.nlm.nih... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/19849665",
"endSection": "abstract",
"offsetInBeginSection": 1772,
"offsetInEndSection": 2068,
"text": "Treatment with a murine anti-ICAM-1 antibody (enlimomab) has been investigated in patients with acute ischemic... | 11 | BioASQ-training11b | null | null | 5e44c33a48dab47f26000020 | 14 |
yesno | Have microRNAs been implicated in pharmacogenomics? | ['yes'] | [
"yes"
] | ['Yes. MicroRNAs have been implicated in pharmacogenomics.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/23376192",
"http://www.ncbi.nlm.nih.gov/pubmed/23189953",
"http://www.ncbi.nlm.nih.gov/pubmed/22630332",
"http://www.ncbi.nlm.nih.gov/pubmed/22445829",
"http://www.ncbi.nlm.nih.gov/pubmed/21499217",
"http://www.ncbi.nlm.nih.gov/pubmed/21412770",
"http://www.ncbi.nlm.n... | [
{
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"document": "http://www.ncbi.nlm.nih.gov/pubmed/23376192",
"endSection": "sections.0",
"offsetInBeginSection": 156,
"offsetInEndSection": 435,
"text": "A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the f... | 5 | BioASQ-training5b | [
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010597",
"http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D035683"
] | [
{
"o": "http://purl.uniprot.org/pubmed/12052143",
"p": "http://www.w3.org/2004/02/skos/core#exactMatch",
"s": "http://purl.uniprot.org/pubmed/12052143"
},
{
"o": "Pharmacogenomics",
"p": "http://purl.uniprot.org/core/name",
"s": "http://purl.uniprot.org/pubmed/15584875"
},
{
"o":... | 5162a089298dcd4e51000043 | 15 |
yesno | Is there an association between Muenke Syndrome and FGFR3 gene mutation? | ['yes'] | [
"yes"
] | ['Yes, Muenke syndrome is caused by point mutation (C749G) in the Fibroblast Growth Factor Receptor3 (FGFR3) gene. It affects 1 in 30,000 newborns and accounts for 25% to 30% of genetic causes of craniosynostosis.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/17103449",
"http://www.ncbi.nlm.nih.gov/pubmed/11571861",
"http://www.ncbi.nlm.nih.gov/pubmed/21403557",
"http://www.ncbi.nlm.nih.gov/pubmed/22872265",
"http://www.ncbi.nlm.nih.gov/pubmed/21233754",
"http://www.ncbi.nlm.nih.gov/pubmed/10696568",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/26028288",
"endSection": "abstract",
"offsetInBeginSection": 579,
"offsetInEndSection": 810,
"text": "RESULTS: Forty-four with a positive FGFR3 mutation, median age 9 years, range 7 months to 52 years were enrolled... | 6 | BioASQ-training6b | [
"http://www.uniprot.org/uniprot/FGFR3_CHICK",
"https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001244",
"http://www.disease-ontology.org/api/metadata/DOID:0060703",
"http://www.uniprot.org/uniprot/FGFR3_PLEWA",
"http://www.uniprot.org/uniprot/FGFR3_HUMAN",
"https://www.n... | null | 5895ec5e7d9090f353000015 | 16 |
yesno | Is the apilimod inhibitor effective against SARS-CoV-2? | ['yes'] | [
"yes"
] | ['To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, a library of known drugs encompassing approximately 12,000 clinical-stage or FDA-approved small molecules were profiled. In a study the identification of 30 known drugs that inhibit viral replication was reportedd. Of these, six were characteri... | [
"http://www.ncbi.nlm.nih.gov/pubmed/32511357"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/32511357",
"endSection": "abstract",
"offsetInBeginSection": 656,
"offsetInEndSection": 1482,
"text": "To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, we profiled a library of known drugs ... | 11 | BioASQ-training11b | null | null | 60324b771cb411341a000139 | 17 |
yesno | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | ['yes'] | [
"yes"
] | ['Yes. Gfi-1B is a transcriptional repressor essential for the regulation of erythropoiesis and megakaryopoiesis. Gfi-1b(-/-) embryonic stem cells fail to contribute to red cells of adult chimeras. Gfi-1b(-/-) embryos exhibit delayed maturation of primitive erythrocytes and subsequently die with failure to produce def... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22960038",
"http://www.ncbi.nlm.nih.gov/pubmed/22699452",
"http://www.ncbi.nlm.nih.gov/pubmed/22668850",
"http://www.ncbi.nlm.nih.gov/pubmed/22399799",
"http://www.ncbi.nlm.nih.gov/pubmed/21606163",
"http://www.ncbi.nlm.nih.gov/pubmed/21170035",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/22960038",
"endSection": "abstract",
"offsetInBeginSection": 0,
"offsetInEndSection": 252,
"text": "Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activ... | 5 | BioASQ-training5b | [
"http://www.uniprot.org/uniprot/GFI1B_HUMAN",
"http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030097",
"http://www.uniprot.org/uniprot/GFI1B_MOUSE"
] | [] | 553bd2f0f321868558000008 | 18 |
yesno | Is rilonacept effective for pericarditis? | ['yes'] | [
"yes"
] | ['Yes, rilonacept is effective for pericarditis.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/34459270",
"http://www.ncbi.nlm.nih.gov/pubmed/34556390",
"http://www.ncbi.nlm.nih.gov/pubmed/34599390",
"http://www.ncbi.nlm.nih.gov/pubmed/34528670",
"http://www.ncbi.nlm.nih.gov/pubmed/34569270"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/34556390",
"endSection": "abstract",
"offsetInBeginSection": 783,
"offsetInEndSection": 1150,
"text": " Concerning acute recurrent pericarditis (RP), an innovative interaction between cardiologists, internists and ... | 12 | BioASQ-training12b | null | null | 61f7cb37882a024a10000029 | 19 |
yesno | Are Conserved Nonexonic Elements (CNEEs) important in phylogenomics research? | ['yes'] | [
"yes"
] | ['Yes. Conserved Nonexonic Elements (CNEEs) appear to be promising as phylogenomic markers, yielding phylogenetic resolution as high as for UCEs and introns but with fewer gaps, less ambiguity in alignments and with patterns of nucleotide substitution more consistent with the assumptions of commonly used methods of phy... | [
"http://www.ncbi.nlm.nih.gov/pubmed/28417603",
"http://www.ncbi.nlm.nih.gov/pubmed/28637293"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/28637293",
"endSection": "abstract",
"offsetInBeginSection": 1555,
"offsetInEndSection": 1865,
"text": "Overall, CNEEs appear to be promising as phylogenomic markers, yielding phylogenetic resolution as high as for... | 11 | BioASQ-training11b | null | null | 5a6e18d8b750ff4455000038 | 20 |
yesno | Does Rhamnose have any effect on aging? | ['yes'] | [
"yes"
] | ['Yes, Rhamnose does have an effect on aging.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/28855134",
"http://www.ncbi.nlm.nih.gov/pubmed/22099844"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/28855134",
"endSection": "abstract",
"offsetInBeginSection": 740,
"offsetInEndSection": 892,
"text": "The monosaccharide analysis showed that rhamnose (Rha) and glucose (Glu) may play vital roles in maintaining the... | 11 | BioASQ-training11b | null | null | 5c840daf617e120c34000007 | 21 |
yesno | Is telomestatin, a novel statin drug used to treat high cholesterol? | ['no'] | [
"no"
] | ['Telomestatin is a natural product isolated from Streptomyces anulatus 3533-SV4 and has been shown to be a very potent telomerase inhibitor and is used to treat cancer.', 'Telomestatin is a natural product isolated from Streptomyces anulatus 3533-SV4 and has been shown to be a very potent telomerase inhibitor.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/11878947",
"http://www.ncbi.nlm.nih.gov/pubmed/28611443",
"http://www.ncbi.nlm.nih.gov/pubmed/23909929",
"http://www.ncbi.nlm.nih.gov/pubmed/16652154",
"http://www.ncbi.nlm.nih.gov/pubmed/15283144",
"http://www.ncbi.nlm.nih.gov/pubmed/12917635"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/11878947",
"endSection": "abstract",
"offsetInBeginSection": 0,
"offsetInEndSection": 139,
"text": "Telomestatin is a natural product isolated from Streptomyces anulatus 3533-SV4 and has been shown to be a very pot... | 11 | BioASQ-training11b | null | null | 623a24d6f0baec9a1b000002 | 22 |
yesno | Was modafinil tested for schizophrenia treatment? | ['yes'] | [
"yes"
] | ['Yes. Modafinil has been shown to improve attention, memory, executive function and antipsychotic-induced parkinsonism in patients with schizophrenia. However, some authors have failed to demonstrate beneficial action of modafinil for schizophrenia.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/23938173",
"http://www.ncbi.nlm.nih.gov/pubmed/22820555",
"http://www.ncbi.nlm.nih.gov/pubmed/22820554",
"http://www.ncbi.nlm.nih.gov/pubmed/23983964",
"http://www.ncbi.nlm.nih.gov/pubmed/21947320",
"http://www.ncbi.nlm.nih.gov/pubmed/21909634",
"http://www.ncbi.nlm.n... | [
{
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/23938173",
"endSection": "title",
"offsetInBeginSection": 0,
"offsetInEndSection": 226,
"text": "Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cogn... | 5 | BioASQ-training5b | [
"http://www.biosemantics.org/jochem#4259639",
"http://www.disease-ontology.org/api/metadata/DOID:5419"
] | [] | 54fc845e6ea36a810c000005 | 23 |
yesno | Is Alpers disease inherited in an autosomal recessive mode? | ['yes'] | [
"yes"
] | ['Alpers disease is a fatal neurogenetic disorder first described more than 70 years ago. It is an autosomal recessive, developmental mitochondrial DNA depletion disorder characterized by deficiency in mitochondrial DNA polymerase gamma (POLG) catalytic activity, refractory seizures, neurodegeneration, and liver diseas... | [
"http://www.ncbi.nlm.nih.gov/pubmed/22006280",
"http://www.ncbi.nlm.nih.gov/pubmed/16181814",
"http://www.ncbi.nlm.nih.gov/pubmed/15122711",
"http://www.ncbi.nlm.nih.gov/pubmed/7897414",
"http://www.ncbi.nlm.nih.gov/pubmed/1861211",
"http://www.ncbi.nlm.nih.gov/pubmed/21451360",
"http://www.ncbi.nlm.nih... | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/22006280",
"endSection": "abstract",
"offsetInBeginSection": 0,
"offsetInEndSection": 78,
"text": "Alpers-Huttenlocher syndrome (AHS) is a very rare autosomal recessive disorder"
},
{
"beginSection": "abstr... | 5 | BioASQ-training5b | [] | [] | 5718a69e7de986d80d00000a | 24 |
yesno | Are there interactomes available for POU5F1 and SOX2? | ['yes'] | [
"yes"
] | ['Yes. Long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) have been assayed using 4C-Seq technique. Their frequent interacting regions mainly overlap with early DNA replication domains. The interactomes are associated with active histone marks and en... | [
"http://www.ncbi.nlm.nih.gov/pubmed/23549118"
] | [
{
"beginSection": "title",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/23549118",
"endSection": "title",
"offsetInBeginSection": 0,
"offsetInEndSection": 76,
"text": "The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells."
},
{
"beginSection": "abstract",
... | 5 | BioASQ-training5b | [
"http://www.uniprot.org/uniprot/PO5F1_HUMAN",
"http://www.uniprot.org/uniprot/PO5F1_MACMU",
"http://www.uniprot.org/uniprot/PO5F1_DANRE",
"http://www.uniprot.org/uniprot/PO5F1_PIG",
"http://www.uniprot.org/uniprot/PO5F1_PANTR",
"http://www.uniprot.org/uniprot/PO5F1_BOVIN",
"http://www.uniprot.org/unipro... | [] | 56c85f675795f9a73e000013 | 25 |
yesno | Is there any linear-time and linear-space algorithm for the computation of avoided words in biological sequences? | ['yes'] | [
"yes"
] | ['Yes. There is a linear-time and linear-space algorithm for the computation of avoided words of length k in a given sequence x.'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/28293277"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/28293277",
"endSection": "abstract",
"offsetInBeginSection": 1526,
"offsetInEndSection": 1979,
"text": "The systematic search for avoided words is particularly useful for biological sequence analysis. We present a ... | 11 | BioASQ-training11b | null | null | 5a6d022ab750ff445500002a | 26 |
yesno | Is SARS virus interacting with ACE2 encoded protein? | ['yes'] | [
"yes"
] | ['Yes,\nThe infection of target cells by the SARS CoV is mediated through the interaction of the viral Spike (S) protein (1255 amino acids) and its cellular receptor, angiotensin-converting enzyme 2 (ACE2).'] | [
"http://www.ncbi.nlm.nih.gov/pubmed/26487711",
"http://www.ncbi.nlm.nih.gov/pubmed/27082314",
"http://www.ncbi.nlm.nih.gov/pubmed/29190287",
"http://www.ncbi.nlm.nih.gov/pubmed/30356097",
"http://www.ncbi.nlm.nih.gov/pubmed/30102747"
] | [
{
"beginSection": "abstract",
"document": "http://www.ncbi.nlm.nih.gov/pubmed/30102747",
"endSection": "abstract",
"offsetInBeginSection": 0,
"offsetInEndSection": 286,
"text": "The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers bin... | 11 | BioASQ-training11b | null | null | 5e80675d835f4e4777000026 | 27 |
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