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8,981,846 | 1997-01-16 | 2019-11-01 | 0965-2302 | Accident and emergency nursing | Concepts related to Chinese patients' perceptions of health, illness and person: issues of conceptual clarity. | Shih F J | eng | null | Journal Article, Review | null | null | 8981846, S0965-2302(96)90086-7, 10.1016/s0965-2302(96)90086-7 | Since most health professionals who care for Chinese patients are trained using Western medical educational systems, they are often unaware of the complex Chinese culture that influences their patients' responses to care. Discrepancies often exist between health professionals' and Chinese patients' perceptions of healt... | Attitude to Health, China, Humans, Medicine, Chinese Traditional, Philosophy, Religion and Medicine, Transcultural Nursing | null |
8,981,847 | 1997-01-16 | 2019-11-01 | 0965-2302 | Accident and emergency nursing | Developments in nursing in accident and emergency services: providing nursing advice to the Scottish Office Department of Health. | Davidson J | eng | null | Journal Article | null | null | 8981847, S0965-2302(96)90089-2, 10.1016/s0965-2302(96)90089-2 | null | Emergency Nursing, Health Planning, Humans, Job Description, Organizational Innovation, Scotland | null |
8,981,848 | 1997-01-16 | 2019-11-01 | 0887-9303 | Critical care nursing quarterly | New ventilatory strategies in acute respiratory failure. | Gowski D T, Miro A M | eng | null | Journal Article, Review | Nitric Oxide | null | 8981848, 10.1097/00002727-199619030-00002 | New management options for acute respiratory failure aim at avoiding ventilator-induced lung injury while maintaining adequate gas exchange. Selected approaches examined in this article include methods to augment carbon dioxide elimination with tracheal gas insufflation, venovenous extracorporeal carbon dioxide removal... | Acute Disease, Critical Care, Extracorporeal Membrane Oxygenation, Humans, Nitric Oxide, Pulmonary Gas Exchange, Respiration, Artificial, Respiratory Insufficiency | null |
8,981,849 | 1997-01-16 | 2020-12-09 | 0887-9303 | Critical care nursing quarterly | Pressure controlled-inverse ratio ventilation. | Delgado E | eng | null | Journal Article, Review | null | null | 8981849, 10.1097/00002727-199619030-00003 | One of the many challenges in the management of the patient with adult respiratory distress syndrome is optimal application of mechanical ventilation. Pressure controlled-inverse ratio ventilation has surfaced as a possible alternative to conventional ventilation for patients affected by this condition. In pressure con... | Adult, Clinical Protocols, Critical Care, Humans, Patient Care Planning, Positive-Pressure Respiration, Respiratory Distress Syndrome | null |
8,981,850 | 1997-01-16 | 2019-11-01 | 0887-9303 | Critical care nursing quarterly | Terminal weaning from mechanical ventilation: planning and process. | Tasota F J, Hoffman L A | eng | null | Journal Article, Review | null | null | 8981850, 10.1097/00002727-199619030-00004 | There are two major goals of critical care: (1) to save those with a chance to live and (2) to help patients who are dying have a peaceful and dignified death. If reversal of the disease process is not possible and the patient is experiencing substantial pain and suffering, goals need to be reviewed and potentially red... | Critical Care, Decision Trees, Ethics, Nursing, Euthanasia, Passive, Family, Humans, Patient Care Planning, Terminal Care, Ventilator Weaning | null |
8,981,851 | 1997-01-16 | 2019-11-01 | 0887-9303 | Critical care nursing quarterly | Using drug chronotherapy to wean patients from mechanical ventilation. | Clochesy J M, Petty G M, Paschall F E | eng | null | Case Reports, Journal Article, Review | null | null | 8981851, 10.1097/00002727-199619030-00005 | Discontinuation of positive pressure mechanical ventilation results in decreased intrathoracic pressure. Although there has been extensive research into factors associated with weaning adults from mechanical ventilatory support, little attention has been paid to the role of left ventricular performance. Research also h... | Aged, Chronotherapy, Critical Care, Female, Hemodynamics, Humans, Male, Ventilator Weaning | null |
8,981,852 | 1997-01-16 | 2019-11-01 | 0887-9303 | Critical care nursing quarterly | Respiratory care of the postoperative lung transplantation patient. | George E L, Large A A, Boujoukos A J, Tuttle R P | eng | null | Journal Article, Review | null | null | 8981852, 10.1097/00002727-199619030-00006 | The management of patients receiving lung transplantation has been evolving during the last thirty years. Transplant programs have continued to develop both in United States and internationally. Patient evaluations and experiences with procedures help guide the decision as to which type of transplant would best benefit... | Critical Care, Hemodynamics, Humans, Lung Transplantation, Postoperative Care, Respiratory Therapy | null |
8,981,853 | 1997-01-16 | 2019-11-01 | 0887-9303 | Critical care nursing quarterly | High-altitude pulmonary edema: a clinical crisis. | Angerio A D, Kot P A | eng | null | Journal Article, Review | Endothelins, Atrial Natriuretic Factor | null | 8981853, 10.1097/00002727-199619030-00007 | High-altitude pulmonary edema is a serious clinical condition observed in individuals participating in mountain climbing and skiing at high altitudes. High-altitude pulmonary edema is an oncardiogenic form of pulmonary edema. Atrial natriuretic factor and endothelin are implicated and ventilatory support is important i... | Altitude Sickness, Atrial Natriuretic Factor, Critical Care, Endothelins, Humans, Pulmonary Circulation, Pulmonary Edema | null |
8,981,854 | 1997-01-16 | 2019-12-10 | 0887-9303 | Critical care nursing quarterly | Optimizing outcomes in ventilator-dependent patients: challenging critical care practice. | Kite-Powell D M, Sabau D, Ideno K T, Hartgraves D, Dahlberg C G | eng | null | Journal Article | null | null | 8981854, 10.1097/00002727-199619030-00008 | This article examines the structure and process of a collaborative practice team established specifically to improve the quality and financial outcomes of ventilator-dependent patients in a tertiary care teaching hospital. A brief overview of descriptors regarding ventilator-dependent patients is synthesized from the l... | Critical Care, Critical Pathways, Humans, Outcome and Process Assessment, Health Care, Patient Care Team, Respiration, Artificial | null |
8,981,855 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | Developing practice: the contribution of the master's prepared nurse. | Manley K | eng | null | Editorial | null | null | 8981855, 10.1111/j.1365-2702.1996.tb00265.x | null | Career Mobility, Education, Nursing, Graduate, Humans, Nurse Clinicians, Professional Practice | null |
8,981,856 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | The evolving role of the clinical nurse specialist within the comprehensive breast cancer centre. | Poole K | eng | null | Journal Article, Review | null | null | 8981856, 10.1111/j.1365-2702.1996.tb00266.x | The collaborative functioning of a specialist multidisciplinary team is a fundamental prerequisite in the establishment of designated breast cancer units throughout the U.K. It is, therefore, opportune for clinical nurse specialists to examine carefully their unique contribution to the care of women with breast disease... | Breast Neoplasms, Comprehensive Health Care, Female, Health Promotion, Humans, Job Description, Nurse Clinicians, Oncology Nursing | null |
8,981,857 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | Introducing primary nursing: nurses' opinions. | Webb C, Pontin D | eng | null | Journal Article | null | null | 8981857, 10.1111/j.1365-2702.1996.tb00267.x | This article reports on one aspect of a research project carried out to monitor and evaluate the introduction of primary nursing on four demonstration wards in one health authority. Nursing staff working on the wards were interviewed to identify how the changes were affecting them and their work. Stress questionnaires ... | Attitude of Health Personnel, Humans, Job Description, Nursing Methodology Research, Nursing Staff, Hospital, Organizational Innovation, Primary Nursing, Surveys and Questionnaires | null |
8,981,859 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | Paediatric nursing and children's autonomy. | Lowes L | eng | null | Journal Article, Review | null | null | 8981859, 10.1111/j.1365-2702.1996.tb00269.x | The topic of children's rights is a wide-ranging and complex subject, and in recognition of this fact this paper specifically addresses the concept of the right of children to make decisions about their own health-care. This paper explores the many factors which may influence a child's right to autonomy, including fami... | Adolescent, Child, Child Advocacy, Ethics, Nursing, Humans, Patient Participation, Pediatric Nursing | Professional Patient Relationship |
8,981,858 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | Readability of printed educational materials used to inform potential and actual ostomates. | Coey L | eng | null | Journal Article | null | null | 8981858, 10.1111/j.1365-2702.1996.tb00268.x | This paper is primarily concerned with the use of readability formulas to determine the reading ease of printed education materials (PEMs) given to ostomy patients. Whilst the particular clinical focus is stoma care nursing, the content is relevant to all nurses who use printed text to inform their patients. PEMs have ... | Educational Status, Humans, Ostomy, Patient Education as Topic, Reading, Reproducibility of Results, Teaching Materials | null |
8,981,860 | 1997-01-16 | 2019-12-10 | 0962-1067 | Journal of clinical nursing | Coping with rheumatoid arthritis. How can specialist nurses influence it and promote better outcomes? | Newbold D | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | null | null | 8981860, 10.1111/j.1365-2702.1996.tb00270.x | Psychological stressors are said to be an important influence on the outcome of chronic illness such as rheumatoid arthritis (Engel, 1977). Helping patients to cope with stressors is identified as a central concept in the delivery of nursing care (Khan et al., 1994). It is thus reasonable to suggest that rheumatology n... | Adaptation, Psychological, Arthritis, Rheumatoid, Health Promotion, Humans, Models, Psychological, Nurse Clinicians, Outcome Assessment, Health Care | null |
8,981,862 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | Endotracheal suctioning: an example of the problems of relevance and rigour in clinical research. | Wainwright S P, Gould D | eng | null | Journal Article, Review | null | null | 8981862, 10.1111/j.1365-2702.1996.tb00272.x | Endotracheal suctioning is a routine but potentially dangerous procedure. The literature documenting approaches to minimizing the cardiopulmonary complications of endotracheal suctioning is reviewed. Hyperoxygenation, hyperventilation, hyperinflation and the use of adaptors are all evaluated. The effects of endotrachea... | Clinical Nursing Research, Hemodynamics, Humans, Intubation, Intratracheal, Reproducibility of Results, Suction | null |
8,981,861 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | Residents' perspectives of their first 2 weeks in a long-term care facility. | Iwasiw C, Goldenberg D, MacMaster E, McCutcheon S, Bol N | eng | null | Journal Article | null | null | 8981861, 10.1111/j.1365-2702.1996.tb00271.x | This study investigated residents' perspectives of their first 2 weeks in a long-term care facility (LTCF). Twelve residents were interviewed to determine their experiences during the first 2 weeks, their needs, priorities and expectations, and their views about how relocation from home could be facilitated. The consta... | Adaptation, Psychological, Aged, Aged, 80 and over, Attitude to Health, Female, Health Services Needs and Demand, Humans, Inpatients, Male, Nursing Methodology Research, Patient Participation, Skilled Nursing Facilities, Surveys and Questionnaires | null |
8,981,863 | 1997-01-16 | 2019-11-01 | 0962-1067 | Journal of clinical nursing | The management of clinician nutrition in NHS hospitals. | Dhoot R, Georgieva C, Grottrup T, Mahdavian R, Poh R, Hindle T | eng | null | Journal Article | null | null | 8981863, 10.1111/j.1365-2702.1996.tb00273.x | null | Cost-Benefit Analysis, Health Services Research, Hospitals, Humans, Nutritional Support, Patient Care Team, State Medicine, Surveys and Questionnaires, United Kingdom | null |
8,981,864 | 1997-01-16 | 2004-11-17 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Positioning adult health nursing for the future. | Fetter M S | eng | null | Editorial | null | null | 8981864 | null | Forecasting, Humans, Internal Medicine, Perioperative Nursing, Societies, Nursing, Specialties, Nursing, United States | null |
8,981,865 | 1997-01-16 | 2005-11-16 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Tubes: a nurse's guide to enteral feeding devices. | Bowers S | eng | null | Journal Article, Review | null | null | 8981865 | Nurses use a variety of sophisticated enteral feeding devices to provide nutritional feedings directly into the gastrointestinal tract. Nurses must be familiar with all aspects of enteral nutrition support to safely provide care. Appropriate care includes identifying high-risk patients, observing for symptoms of malnut... | Decision Trees, Enteral Nutrition, Humans, Intubation, Gastrointestinal, Nursing Assessment | null |
8,981,866 | 1997-01-16 | 2005-11-16 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Rehabilitating stroke patients in the acute care setting. | Fowler S, Durkee C M, Webb D J | eng | null | Journal Article, Review | null | null | 8981866 | The 1990s has been heralded as the Decade of the Brain. The National Stroke Association refers to stroke as a brain attack. Medical and nursing interventions are aimed at limiting the extent of brain injury, promoting early reperfusion, and preventing complications as a result of secondary injury or hazards of immobili... | Acute Disease, Cerebrovascular Disorders, Humans, Nursing Assessment, Patient Care Planning | null |
8,981,867 | 1997-01-16 | 2007-11-15 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Patient and family education: an interdisciplinary process. | Clay J C, Wyatt L K, Norris G M | eng | null | Journal Article | null | null | 8981867 | An interdisciplinary education and discharge plan was developed in a 404-bed teaching hospital to coordinate and integrate the function of patient and family education across disciplines using one common form. This education plan was instrumental in providing improved documentation of patient and family education in bo... | Family, Humans, Nursing Records, Patient Care Planning, Patient Care Team, Patient Discharge, Patient Education as Topic | null |
8,981,869 | 1997-01-16 | 2005-11-16 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Assessing symptom distress in ambulatory surgery patients. | Swan B A | eng | null | Journal Article, Review | null | null | 8981869 | Symptom distress constitutes a major problem for patients and their families following ambulatory surgery, because managing symptom distress is their responsibility. It is essential that the assessment of symptom distress be an integral part of ambulatory surgery patient care delivery to decrease complications that occ... | Ambulatory Surgical Procedures, Humans, Nursing Assessment, Pain, Postoperative, Psychometrics, Reproducibility of Results, Stress, Psychological | null |
8,981,868 | 1997-01-16 | 2005-11-16 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | The nurse's role in facilitating compliance in clients with hypertension. | Eaton L, Buck E A, Catanzaro J E | eng | null | Journal Article, Review | null | null | 8981868 | Afflicting approximately 50 million people, hypertension costs over $500 million per year and accounts for the largest number of physician office visits per year and the greatest use of prescription drugs. Nurses play a vital role in assessing and managing hypertensive clients' and promoting clients' compliance with tr... | Algorithms, Humans, Hypertension, Life Style, Patient Compliance, Patient Participation | null |
8,981,870 | 1997-01-16 | 2005-11-16 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Oral nutritional supplements. | Bankhead R R | eng | null | Journal Article, Review | null | null | 8981870 | null | Enteral Nutrition, Food, Formulated, Humans, Protein-Energy Malnutrition, Risk Factors | null |
8,981,871 | 1997-01-16 | 2013-11-21 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | New treatment for obesity: dexfenfluramine (Redux). | Bihm B | eng | null | Journal Article | Appetite Depressants, Fenfluramine | null | 8981871 | null | Appetite Depressants, Body Mass Index, Fenfluramine, Humans, Obesity, Patient Selection | null |
8,981,872 | 1997-01-16 | 2004-11-17 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Preferring not-for-profit managed care. | Ott B B | eng | null | Journal Article | null | null | 8981872 | null | Choice Behavior, Ethics, Nursing, Hospitals, Voluntary, Humans, Managed Care Programs, United States | Health Care and Public Health |
8,981,873 | 1997-01-16 | 2006-08-24 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Assisted suicide and terminating life support: the state of the law. | Piotrowicz M S, Leahy W J | eng | null | Case Reports, Journal Article | null | null | 8981873 | null | Adult, Euthanasia, Passive, Humans, Male, Persistent Vegetative State, Suicide, Assisted, United States | Death and Euthanasia, Legal Approach |
8,981,874 | 1997-01-16 | 2007-11-15 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Hormone replacement therapy: helping your patient decide. | Appling S E | eng | null | Journal Article, Review | null | null | 8981874 | null | Decision Making, Estrogen Replacement Therapy, Female, Humans, Middle Aged, Patient Education as Topic | null |
8,981,875 | 1997-01-16 | 2019-12-10 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Integrating guidelines into nursing practice. | Schumacher S B | eng | null | Journal Article | null | null | 8981875 | null | Humans, Nursing Care, Outcome and Process Assessment, Health Care, Patient Care Planning, Practice Guidelines as Topic | null |
8,981,876 | 1997-01-16 | 2004-11-17 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Case management in acute care. | Weston M A | eng | null | Journal Article | null | null | 8981876 | null | Academic Medical Centers, Acute Disease, Case Management, Humans, Models, Nursing | null |
8,981,877 | 1997-01-16 | 2004-11-17 | 1092-0811 | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | Moving research-based practice throughout the health care system. | Goode C J, Titler M G | eng | null | Journal Article | null | null | 8981877 | null | Diffusion of Innovation, Humans, Models, Nursing, Nurse Clinicians, Nursing Care, Organizational Innovation | null |
8,981,878 | 1997-01-30 | 2018-11-30 | 0009-921X | Clinical orthopaedics and related research | Tissue reactions to plastic and metallic wear products of joint endoprostheses. | Willert H G, Semlitsch M | eng | null | Biography, Classical Article, Historical Article, Journal Article, Portrait | Biocompatible Materials, Metals, Plastics | IM | 8981878 | null | Austria, Biocompatible Materials, Foreign-Body Reaction, Germany, History, 20th Century, Humans, Joint Prosthesis, Metals, Plastics, Prostheses and Implants | null |
8,981,879 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | The Otto Aufranc Award. Skeletal response to well fixed femoral components inserted with and without cement. | Maloney W J, Sychterz C, Bragdon C, McGovern T, Jasty M, Engh C A, Harris W H | eng | null | Journal Article | null | IM | 8981879 | Previous studies evaluating femoral remodeling after total hip arthroplasty have used clinical radiographs and dual energy xray absorptiometry. Limitation of these techniques make it impossible to quantify the magnitude of bone loss in terms of cortical thinning and cortical bone area and bone mineral density changes. ... | Adult, Aged, Aged, 80 and over, Bone Density, Bone Remodeling, Bone Resorption, Cementation, Female, Femur, Hip Prosthesis, Humans, Male, Middle Aged | null |
8,981,880 | 1997-01-30 | 2022-03-21 | 0009-921X | Clinical orthopaedics and related research | The John Charnley Award. Natural history of thromboembolic disease after total hip arthroplasty. | Pellegrini V D, Clement D, Lush-Ehmann C, Keller G S, Evarts C M | eng | null | Journal Article | null | IM | 8981880 | In 1079 consecutive patients undergoing total hip arthroplasty between 1984 and 1992, complications of thromboembolic disease and related anticoagulation were reviewed for 6 months after hospital discharge, including cost data. Of 347 patients having venograms, 78 (22.5%) had positive results and 269 (77.5%) had negati... | Aged, Costs and Cost Analysis, Hip Prosthesis, Humans, Middle Aged, Phlebography, Postoperative Complications, Thromboembolism, Thrombolytic Therapy, Time Factors | null |
8,981,881 | 1997-01-30 | 2022-04-08 | 0009-921X | Clinical orthopaedics and related research | The Frank Stinchfield Award. 3-Dimensional sliding/contact computational simulation of total hip wear. | Maxian T A, Brown T D, Pedersen D R, Callaghan J J | eng | AR-43314 (NIAMS NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Polyethylenes | IM | 8981881 | Polyethylene wear in total hip replacements is a complex, multifactorial process. A tribologically grounded finite element formulation was developed to make quantitative estimates of polyethylene wear in total hip arthroplasty, incorporating the combined influences of contact stress, sliding distance, and a surface spe... | Computer Simulation, Hip Prosthesis, Humans, Polyethylenes, Prostheses and Implants, Stress, Mechanical | null |
8,981,882 | 1997-01-30 | 2018-11-30 | 0009-921X | Clinical orthopaedics and related research | Crevice corrosion of cemented titanium alloy stems in total hip replacements. | Willert H G, Brobäck L G, Buchhorn G H, Jensen P H, Köster G, Lang I, Ochsner P, Schenk R | eng | null | Address | Alloys, Titanium | IM | 8981882 | Twenty-eight cemented Müller straight femoral stems of titanium forged alloys were mainly revised for causing pain in the patient. The pain pattern differed from aseptic loosening and pain recurred only 14.5 months on average after implantation. The character of pain was dull, permanent, and increased at rest. Some pat... | Adult, Aged, Aged, 80 and over, Alloys, Cementation, Corrosion, Female, Femur, Foreign Bodies, Hip Prosthesis, Humans, Male, Middle Aged, Osteoarthritis, Hip, Prosthesis Design, Prosthesis Failure, Titanium | null |
8,981,884 | 1997-01-30 | 2013-11-21 | 0009-921X | Clinical orthopaedics and related research | Fatigue strength of polyethylene after sterilization by gamma irradiation or ethylene oxide. | Ries M D, Weaver K, Rose R M, Gunther J, Sauer W, Beals N | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Polyethylenes, Ethylene Oxide | IM | 8981884 | The oxidation level of ultrahigh molecular weight polyethylene specimens sterilized by gamma irradiation in either air or Ar gas was compared with that of unsterilized and ethylene oxide sterilized ultrahigh molecular weight polyethylene. The fatigue strength of ultrahigh molecular weight polyethylene specimens sterili... | Biophysical Phenomena, Biophysics, Ethylene Oxide, Gamma Rays, Humans, Infant, Newborn, Joint Prosthesis, Materials Testing, Molecular Weight, Oxidation-Reduction, Polyethylenes, Prostheses and Implants, Sterilization | null |
8,981,883 | 1997-01-30 | 2013-11-21 | 0009-921X | Clinical orthopaedics and related research | Overview of polyethylene as a bearing material: comparison of sterilization methods. | Collier J P, Sutula L C, Currier B H, Currier J H, Wooding R E, Williams I R, Farber K B, Mayor M B | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S. | Polyethylenes, Ethylene Oxide | IM | 8981883 | Polyethylene has been used for more than 30 years as an orthopaedic bearing material; however, there has been recent concern regarding the early failure of a small percentage of the polyethylene bearings. The damage seen in some retrieved polyethylene components has been linked to gamma radiation sterilization in air, ... | Electron Spin Resonance Spectroscopy, Ethylene Oxide, Gamma Rays, Humans, Materials Testing, Oxidation-Reduction, Polyethylenes, Spectroscopy, Fourier Transform Infrared, Sterilization, Tensile Strength, Weight-Bearing | null |
8,981,885 | 1997-01-30 | 2006-11-15 | 0009-921X | Clinical orthopaedics and related research | Engineering issues and wear performance of metal on metal hip implants. | Chan F W, Bobyn J D, Medley J B, Krygier J J, Yue S, Tanzer M | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Metals | IM | 8981885 | A major concern in total hip arthroplasty is the generation of polyethylene wear particles at the articulating surfaces and resulting macrophage mediated periimplant osteolysis. There is renewed interest in metal on metal bearings as a solution to this problem in view of their potential for greatly improved wear perfor... | Hip Prosthesis, Humans, Lubrication, Materials Testing, Metals, Osteolysis, Prosthesis Design | null |
8,981,886 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | Modern metal on metal articulation for total hip replacements. | Dorr L D, Hilton K R, Wan Z, Markovich G D, Bloebaum R | eng | null | Journal Article | Metals | IM | 8981886 | Between 1991 and 1994, 70 patients received total hip replacements with metal on metal articulation. The results of 54 of these patients with 54 hips who have a 2- to 4-year (2.7-year average) followup are reported. Patients were prospectively evaluated using the Harris hip score, a patient self assessment form, and ra... | Adult, Aged, Aged, 80 and over, Female, Foreign Bodies, Hip Prosthesis, Humans, Male, Metals, Middle Aged, Osteolysis, Prospective Studies, Prosthesis Design, Prosthesis Failure, Synovial Fluid | null |
8,981,887 | 1997-01-30 | 2016-11-24 | 0009-921X | Clinical orthopaedics and related research | Primary hybrid total hip arthroplasty: an interim followup. | Callaghan J J, Tooma G S, Olejniczak J P, Goetz D D, Johnston R C | eng | AR-43314 (NIAMS NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, P.H.S. | null | IM | 8981887 | The senior authors' initial experience with primary hybrid hip replacement in patients with osteoarthritis was studied to evaluate the efficacy of the procedure. Hybrid total hip arthroplasty (uncemented Harris-Galante acetabular component and cemented Iowa precoated femoral component) was performed in 131 consecutive,... | Aged, Aged, 80 and over, Female, Follow-Up Studies, Hip Joint, Hip Prosthesis, Humans, Male, Middle Aged, Osteoarthritis, Hip, Prosthesis Design, Prosthesis Failure, Radiography, Reoperation, Treatment Outcome | null |
8,981,888 | 1997-01-30 | 2016-11-24 | 0009-921X | Clinical orthopaedics and related research | Hybrid primary total hip arthroplasty: a 5- to 9-year followup study. | Lewallen D G, Cabanela M E | eng | null | Journal Article | null | IM | 8981888 | One hundred fifty-two hips were reviewed at a minimum of 5 years after hybrid primary total hip arthroplasty using uncemented porous coated acetabular components and cemented femoral stems to determine the intermediate term durability of this method of fixation. Five hips (3.6%) have been revised: 1 for dislocation (0.... | Adult, Aged, Aged, 80 and over, Arthritis, Rheumatoid, Cementation, Follow-Up Studies, Hip Joint, Hip Prosthesis, Humans, Middle Aged, Osteoarthritis, Hip, Osteolysis, Prosthesis Failure, Radiography, Reoperation, Treatment Outcome | null |
8,981,889 | 1997-01-30 | 2016-11-24 | 0009-921X | Clinical orthopaedics and related research | Hybrid total hip arthroplasty: 7- to 10-year results. | Berger R A, Kull L R, Rosenberg A G, Galante J O | eng | null | Journal Article | null | IM | 8981889 | One hundred fifty consecutive hybrid total hip arthroplasties in 139 patients were performed using an uncemented hemispheric porous coated acetabular component (HGP-I) with screws and a femoral component (Precoat) cemented with contemporary cementing technique. The average patient age was 67 years (range, 39-85 years).... | Adult, Aged, Aged, 80 and over, Cementation, Female, Follow-Up Studies, Hip Joint, Hip Prosthesis, Humans, Male, Middle Aged, Osteolysis, Prosthesis Failure, Radiography, Treatment Outcome | null |
8,981,890 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | Hybrid total hip arthroplasty: a 7- to 11-year followup. | Goldberg V M, Ninomiya J, Kelly G, Kraay M | eng | null | Journal Article | null | IM | 8981890 | A consecutive series of 125 hybrid total hip arthroplasties were performed in 120 patients by a single surgeon and were observed for an average of 8.6 years (range, 7-11 years). There were 38 men and 82 women with an average age of 71 years (range, 25-87 years) at the time of surgery. The diagnoses included primary and... | Adult, Aged, Female, Follow-Up Studies, Hip Prosthesis, Humans, Male, Middle Aged, Osteoarthritis, Hip, Prosthesis Failure, Reoperation, Treatment Outcome | null |
8,981,891 | 1997-01-30 | 2005-11-16 | 0009-921X | Clinical orthopaedics and related research | Hybrid total hip replacement: rationale and intermediate clinical results. | Harris W H | eng | null | Journal Article, Review | null | IM | 8981891 | The decade of the 1980s was considered by many hip surgeons to be the decade of cement versus cementless. An alternate approach was introduced in which the acetabular component used was cementless and the femoral component was fixed with cement. This has been called the hybrid total hip replacement. The rationale for t... | Cementation, Hip Prosthesis, Humans, Osteolysis, Prosthesis Failure, Reoperation, Treatment Outcome | null |
8,981,892 | 1997-01-30 | 2022-04-09 | 0009-921X | Clinical orthopaedics and related research | Management of limb length inequality during total hip replacement. | Jasty M, Webster W, Harris W | eng | null | Journal Article | null | IM | 8981892 | Significant limb length inequality is not an uncommon problem after total hip replacement. Preoperative measurement of limb length inequality, preoperative planning with radiographic templates, and intraoperative correction with measurements of limb lengths before and after the insertion of the trial components using s... | Hip Prosthesis, Humans, Leg Length Inequality, Osteoarthritis, Hip, Postoperative Complications, Retrospective Studies, Treatment Outcome | null |
8,981,893 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | Effects of leg length discrepancies on the forces at the hip joint. | Brand R A, Yack H J | eng | null | Journal Article | null | IM | 8981893 | The authors questioned whether leg length discrepancies of the magnitude ordinarily seen after total hip reconstruction (<2 cm) would substantially alter hip joint forces. Using conventional gait analysis techniques to ascertain intersegmental resultant hip forces and moments, the authors used lifts to simulate leg len... | Adult, Gait, Hip Joint, Humans, Leg Length Inequality, Pilot Projects | null |
8,981,894 | 1997-01-30 | 2022-03-21 | 0009-921X | Clinical orthopaedics and related research | Fixation stability of olecranon osteotomies. | Petraco D M, Koval K J, Kummer F J, Zuckerman J D | eng | null | Clinical Trial, Journal Article, Randomized Controlled Trial | null | IM | 8981894 | Eighteen pairs of fresh frozen human upper extremities were selected and each randomized to 2 of 3 olecranon osteotomy and fixation technique groups: (1) transverse osteotomy with 0.062 Kirschner wire and tension band fixation; (2) chevron osteotomy with 6.5-mm cancellous lag screw and tension band fixation; and (3) ob... | Biomechanical Phenomena, Cadaver, Humans, Internal Fixators, Osteotomy, Shoulder | null |
8,981,895 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | Long term evaluation of repaired distal biceps brachii tendon ruptures. | Davison B L, Engber W D, Tigert L J | eng | null | Journal Article | null | IM | 8981895 | A long term evaluation was performed on 8 patients who had rupture of the distal biceps tendon repaired using the 2-incision technique. The length of followup ranged from 1 to 11 years with an average of 6 years. Goniometric range of motion and isokinetic strength testing were performed on all patients. All patients at... | Adult, Arm Injuries, Elbow Joint, Humans, Male, Middle Aged, Range of Motion, Articular, Rupture, Tendon Injuries, Treatment Outcome | null |
8,981,896 | 1997-01-30 | 2011-11-17 | 0009-921X | Clinical orthopaedics and related research | Physical signs in lumbar disc hernia. | Vucetic N, Svensson O | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 8981896 | In a prospective study of 163 consecutive patients operated on because they were thought to have lumbar disc hernia, the authors investigated whether physical signs could predict the degree of hernia (complete hernia, incomplete hernia, protruded disc, and normal disc) found at surgery. Stepwise discriminant analysis s... | Adolescent, Adult, Aged, Discriminant Analysis, Female, Humans, Intervertebral Disc Displacement, Lumbar Vertebrae, Male, Middle Aged, Neurologic Examination, Prospective Studies, Range of Motion, Articular, Scoliosis | null |
8,981,897 | 1997-01-30 | 2016-11-24 | 0009-921X | Clinical orthopaedics and related research | Dysplasia epiphysealis hemimelica of the sacroiliac joint: a case report. | Segal L S, Vrahas M S, Schwentker E P | eng | null | Case Reports, Journal Article | null | IM | 8981897 | Dysplasia epiphysealis hemimelica is a rare developmental abnormality involving aberrant epiphyseal cartilage growth. This is the first known case report describing dysplasia epiphysealis hemimelica arising from the sacroiliac joint. The operative technique described through an indirect computed tomography guided appro... | Bone Neoplasms, Bone Screws, Child, Epiphyses, Humans, Ilium, Male, Osteochondroma, Sacroiliac Joint, Tomography, X-Ray Computed | null |
8,981,898 | 1997-01-30 | 2006-11-15 | 0009-921X | Clinical orthopaedics and related research | Trochanteric osteotomy and wire fixation: a comparison of 2 techniques. | Nercessian O A, Newton P M, Joshi R P, Sheikh B, Eftekhar N S | eng | null | Comparative Study, Journal Article | null | IM | 8981898 | Between 1986 and 1989, 190 patients (214 hips) with the diagnosis of osteoarthritis or posttraumatic arthritis underwent cemented Charnley total hip replacement surgeries via the biplane or single plane transtrochanteric approach. The technique of surgery was identical in every aspect except for the technique of the tr... | Adult, Aged, Aged, 80 and over, Arthritis, Bone Wires, Female, Femur, Hip Prosthesis, Humans, Male, Middle Aged, Osteoarthritis, Hip, Osteotomy, Retrospective Studies, Treatment Outcome, Wounds and Injuries | null |
8,981,899 | 1997-01-30 | 2022-04-08 | 0009-921X | Clinical orthopaedics and related research | Primary cementless hip arthroplasty with a titanium plasma sprayed prosthesis. | Hozack W J, Rothman R H, Eng K, Mesa J | eng | null | Journal Article | Titanium | IM | 8981899 | One hundred two patients underwent 105 primary uncemented total hip arthroplasties and were reviewed at a minimum of 5 years after operation (mean, 6.1 years). The components were titanium alloy with a titanium plasma spray coating. The acetabular revision rate was 11.4%. Acetabular cavitary lytic lesions were identifi... | Adult, Aged, Arthritis, Rheumatoid, Cementation, Female, Femur Head Necrosis, Hip Joint, Hip Prosthesis, Humans, Male, Middle Aged, Osteoarthritis, Hip, Osteolysis, Prosthesis Design, Prosthesis Failure, Radiography, Retrospective Studies, Titanium | null |
8,981,900 | 1997-01-30 | 2022-03-09 | 0009-921X | Clinical orthopaedics and related research | Dislocations and the femoral head size in primary total hip arthroplasty. | Hedlundh U, Ahnfelt L, Hybbinette C H, Wallinder L, Weckström J, Fredin H | eng | null | Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't | null | IM | 8981900 | The dislocation rate of 3197 Charnley prostheses with 22 mm head in which the surgery was done between 1979 and 1991 in 2 orthopaedic centers was compared with that of 2875 Lubinus prostheses with 32 mm head in which the surgery was done between 1980 to 1991 in 3 other centers. A 1-year followup showed an equal rate of... | Aged, Female, Femur Head, Hip Prosthesis, Humans, Logistic Models, Male, Middle Aged, Postoperative Complications, Prosthesis Design, Retrospective Studies | null |
8,981,901 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | Catastrophic failure of a conforming type of total knee replacement: a case report. | Li E C, Ritter M A, Montgomery T, Furman B D, Li S, Wright T M | eng | null | Case Reports, Journal Article | Polyethylenes | IM | 8981901 | A case study is presented to illustrate the concept of femoral component failure secondary to polyethylene wear in a 67 year old man, 13 years after he had conforming type total knee replacements. This case illustrates the theory that this observed problem may be a leading cause of failure in conforming and nonconformi... | Aged, Calorimetry, Differential Scanning, Crystallization, Humans, Knee Prosthesis, Male, Polyethylenes, Prosthesis Failure | null |
8,981,902 | 1997-01-30 | 2022-12-07 | 0009-921X | Clinical orthopaedics and related research | Fibrosarcoma of the toe: a destructive lesion of the distal phalanx. | Inoue A, Hasegawa T, Ikata T, Hizawa K | eng | null | Case Reports, Journal Article | null | IM | 8981902 | A rare case of well differentiated fibrosarcoma occurring in the left second toe is described in a 12-year-old boy who presented with a destructive lesion that had almost totally destroyed the distal phalanx, except for the epiphysis. Amputated specimens showed microscopic evidence of proliferation of uniform spindle c... | Amputation, Surgical, Child, Fibrosarcoma, Foot Diseases, Humans, Magnetic Resonance Imaging, Male, Toes | null |
8,981,903 | 1997-01-30 | 2022-04-08 | 0009-921X | Clinical orthopaedics and related research | Effect of cefazolin and vancomycin on osteoblasts in vitro. | Edin M L, Miclau T, Lester G E, Lindsey R W, Dahners L E | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Anti-Bacterial Agents, Cephalosporins, Vancomycin, Cefazolin | IM | 8981903 | The effect of cefazolin and vancomycin on osteoblast-like cells was studied. Cells from the MG-63 human osteosarcoma cell line were grown in antibiotic free media and exposed to concentrations of cefazolin and vancomycin at order of magnitude intervals between 0 and 10,000 microg/ml. For cefazolin, a second interval wa... | Anti-Bacterial Agents, Cefazolin, Cell Death, Cell Division, Cephalosporins, Dose-Response Relationship, Drug, Humans, Osteoblasts, Tumor Cells, Cultured, Vancomycin | null |
8,981,904 | 1997-01-30 | 2006-11-15 | 0009-921X | Clinical orthopaedics and related research | Basic fibroblast growth factor promotes bone ingrowth in porous hydroxyapatite. | Wang J S, Aspenberg P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Bone Substitutes, Drug Carriers, Hydroxyapatites, Fibroblast Growth Factor 2 | IM | 8981904 | The effect of basic fibroblast growth factor on tissue ingrowth and differentiation in porous hydroxyapatite of coralline origin was studied in a bone chamber model. The hydroxyapatite with or without basic fibroblast growth factor was placed in 22 mm3 titanium bone conduction chambers implanted bilaterally in rat tibi... | Animals, Bone Substitutes, Bone and Bones, Dose-Response Relationship, Drug, Drug Carriers, Fibroblast Growth Factor 2, Hydroxyapatites, Male, Osseointegration, Prostheses and Implants, Rats, Rats, Sprague-Dawley | null |
8,981,905 | 1997-01-30 | 2022-03-30 | 0009-921X | Clinical orthopaedics and related research | Congenital metatarsus adductus in early human fetal development: a histologic study. | Morcuende J A, Ponseti I V | eng | null | Journal Article | null | IM | 8981905 | Two feet with congenital metatarsus adductus from fetuses at early development (16 and 19 weeks of gestation) were studied by making serial histologic sections in the horizontal plane of the foot. It was observed that the shape of the medial cuneiform was altered and the first cuneometatarsal joint tilted toward the me... | Embryonic and Fetal Development, Foot Deformities, Congenital, Humans, Metatarsus | null |
8,981,907 | 1997-01-30 | 2008-11-20 | 0021-9738 | The Journal of clinical investigation | Surprise? Bacteria glycosylate proteins too. | Tuomanen E I | eng | null | Comment, Editorial | Bacterial Proteins, Glycoproteins | IM | 8981907, 10.1172/JCI119087, PMC507726 | null | Arteriosclerosis, Bacterial Proteins, Chlamydia trachomatis, Glycoproteins, Glycosylation | null |
8,981,906 | 1997-01-30 | 2005-03-03 | 0009-921X | Clinical orthopaedics and related research | Incidental cartilage lesion in a 71-year-old man. | Panicek D M, Healey J H, Huvos A G | eng | null | Case Reports, Clinical Conference, Journal Article | null | IM | 8981906 | null | Aged, Bone Neoplasms, Chondrosarcoma, Diagnosis, Differential, Humans, Humerus, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed | null |
8,981,909 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. | Barazzone C, Belin D, Piguet P F, Vassalli J D, Sappino A P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Amyloid beta-Protein Precursor, Carrier Proteins, Plasminogen Activator Inhibitor 1, Protease Nexins, RNA Probes, RNA, Messenger, Receptors, Cell Surface, Fibrin, Tissue Plasminogen Activator, Urokinase-Type Plasminogen Activator, Oxygen | IM | 8981909, 10.1172/JCI119089, PMC507728, 8368324, 8349806, 8118648, 8133887, 7516275, 7921023, 7614818, 7647157, 7544811, 8544402, 8550840, 8611700, 8647939, 8679214, 8825792, 942051, 143664, 7406333, 6374011, 3838543, 2930999, 3953768, 3087993, 3106085, 2496309, 2788176, 2583099, 2314423, 2230126, 1900311, 1902065, 2024... | Hyperoxia-induced lung disease is associated with prominent intraalveolar fibrin deposition. Fibrin turnover is tightly regulated by the concerted action of proteases and antiproteases, and inhibition of plasmin-mediated proteolysis could account for fibrin accumulation in lung alveoli. We show here that lungs of mice ... | Amyloid beta-Protein Precursor, Animals, Bronchoalveolar Lavage, Carrier Proteins, Electrophoresis, Fibrin, Fibrinolysis, Histocytochemistry, Humans, Hyaline Membrane Disease, Hyperoxia, Immunohistochemistry, Infant, Newborn, Lung, Lung Injury, Mice, Mice, Inbred Strains, Oxygen, Plasminogen Activator Inhibitor 1, Prot... | null |
8,981,908 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Effects of fluid dynamic forces on vascular cell adhesion. | Konstantopoulos K, McIntire L V | eng | null | Journal Article, Review | Cell Adhesion Molecules, Receptors, Cell Surface, L-Selectin | IM | 8981908, 10.1172/JCI119088, PMC507727, 8551244, 8557755, 8752939, 8704169, 8787668, 347575, 3663936, 1967215, 7506064, 7525838, 7527432, 7532110, 7534768, 7535385, 7542276, 7553859, 8565074 | null | Blood Platelets, Cell Adhesion, Cell Adhesion Molecules, Endothelium, Vascular, Hemodynamics, L-Selectin, Neutrophils, Receptors, Cell Surface | null |
8,981,911 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes. | Bosch A, McCray P B, Chang S M, Ulich T R, Simonet W S, Jolly D J, Davidson B L | eng | null | Journal Article, Research Support, Non-U.S. Gov't | DNA Primers, Fgf7 protein, mouse, Fibroblast Growth Factor 10, Growth Substances, Fibroblast Growth Factor 7, Fibroblast Growth Factors, beta-Galactosidase | IM | 8981911, 10.1172/JCI119091, PMC507730, 2911748, 3049582, 2236051, 1828343, 8054972, 7962522, 7981306, 7533647, 7719931, 7597103, 8589717, 1650585, 1656443, 1729724, 1722351, 1543539, 1667366, 1667382, 1315677, 1420448, 1431684, 1279268, 1482704, 8506951, 8348154, 8399488, 8211118, 8291602, 8298650, 8108431, 8134398, 81... | Retroviral gene transfer to liver without prior injury has not yet been accomplished. We hypothesized that recombinant human keratinocyte growth factor would stimulate proliferation of hepatocytes and allow for efficient in vivo gene transfer with high titer murine Moloney retroviral vectors. This report shows that 48 ... | Animals, Cell Division, Cells, Cultured, DNA Primers, Escherichia coli, Fibroblast Growth Factor 10, Fibroblast Growth Factor 7, Fibroblast Growth Factors, Gene Expression, Gene Transfer Techniques, Genetic Vectors, Growth Substances, Immunohistochemistry, Lac Operon, Liver, Mice, Polymerase Chain Reaction, Retrovirida... | null |
8,981,910 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Identification and localization of polycystin, the PKD1 gene product. | Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke H G, Glücksmann-Kuis A M, Schneider M C, Ericsson M, Reeders S T, Zhou J | eng | DK-40703 (NIDDK NIH HHS, United States); DK-51050 (NIDDK NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Antibodies, Proteins, Recombinant Fusion Proteins, TRPP Cation Channels, polycystic kidney disease 1 protein | IM | 8981910, 10.1172/JCI119090, PMC507729, 713285, 7759112, 6544882, 2873352, 2239929, 1848046, 1614046, 8340115, 8307555, 8176884, 8196285, 7614844, 7633405, 7653531, 7663510, 7581371, 8554072, 8643665, 2995836 | Polycystin, the product of autosomal dominant polycystic kidney disease (ADPKD) 1 gene (PKD1) is the cardinal member of a novel class of proteins. As a first step towards elucidating the function of polycystin and the pathogenesis of ADPKD, three types of information were collected in the current study: the subcellular... | Antibodies, Blotting, Western, Cell Membrane, Cloning, Molecular, Embryo, Mammalian, Gene Expression Regulation, Humans, Immunohistochemistry, Kidney Tubules, Liver, Microscopy, Immunoelectron, Pancreas, Polycystic Kidney, Autosomal Dominant, Proteins, Recombinant Fusion Proteins, Skin, TRPP Cation Channels | null |
8,981,912 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice. | Hicke B J, Watson S R, Koenig A, Lynott C K, Bargatze R F, Chang Y F, Ringquist S, Moon-McDermott L, Jennings S, Fitzwater T, Han H L, Varki N, Albinana I, Willis M C, Varki A, Parma D | eng | null | Journal Article | DNA-Binding Proteins, Deoxyribonucleotides, Lewis X Antigen, Ligands, L-Selectin, Calcium | IM | 8981912, 10.1172/JCI119092, PMC507731, 6866086, 7574500, 2200121, 1714447, 1718992, 1345918, 1374413, 1590996, 1376638, 1382077, 7679406, 7679675, 7680663, 8463234, 7685350, 7692600, 7505206, 7507411, 7513613, 8650187, 8181668, 7515220, 7515914, 7519775, 7522621, 7530461, 7538108, 7775406, 7574477, 2179952 | Selectins participate in the initial events leading to leukocyte extravasation from the blood into tissues. Thus the selectins have generated much interest as targets for antiinflammatory agents. Therapeutic molecules based on the monomeric carbohydrate ligand sialyl Lewis X (SLe(X)) have low affinities and are not spe... | Animals, Binding Sites, Calcium, Cell Adhesion, Cloning, Molecular, DNA-Binding Proteins, Deoxyribonucleotides, Flow Cytometry, L-Selectin, Lewis X Antigen, Ligands, Lymphocytes, Mice, Mice, SCID, Protein Binding, Spectrometry, Fluorescence | null |
8,981,913 | 1997-01-30 | 2022-02-24 | 0021-9738 | The Journal of clinical investigation | Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. | Krinzman S J, De Sanctis G T, Cernadas M, Mark D, Wang Y, Listman J, Kobzik L, Donovan C, Nassr K, Katona I, Christiani D C, Perkins D L, Finn P W | eng | AI-31517 (NIAID NIH HHS, United States); ES-106568 (NIEHS NIH HHS, United States); HL-36110 (NHLBI NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Bronchoconstrictor Agents, CD28 Antigens, Immunoglobulin G, Methacholine Chloride, Immunoglobulin E, Ovalbumin | IM | 8981913, 10.1172/JCI119093, PMC507732, 7028842, 7584144, 6406089, 8548844, 8557973, 8596936, 8666782, 13818688, 3514163, 2952723, 2447813, 2501446, 2215562, 2252260, 1714933, 1913281, 1313950, 1626792, 1639794, 1323143, 1496399, 1332070, 8025950, 8046343, 7520604, 7822784, 7882171, 7767542, 7543139, 7550342, 7481803, 7... | Activation of naive T cells requires at least two signals. In addition to the well characterized interaction of the T cell antigen receptor with the antigen/MHC expressed on an antigen-presenting cell, T cell activation also requires costimulation by a second set of signals. The best characterized costimulatory recepto... | Airway Resistance, Animals, Bronchoalveolar Lavage, Bronchoconstrictor Agents, CD28 Antigens, Cell Division, Disease Models, Animal, Flow Cytometry, Histocytochemistry, Hypersensitivity, Immunoglobulin E, Immunoglobulin G, Immunohistochemistry, Inflammation, Lung, Male, Methacholine Chloride, Mice, Mice, Inbred BALB C,... | null |
8,981,914 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Induction of neonatal tolerance by plasmid DNA vaccination of mice. | Mor G, Yamshchikov G, Sedegah M, Takeno M, Wang R, Houghten R A, Hoffman S, Klinman D M | eng | null | Journal Article, Research Support, U.S. Gov't, Non-P.H.S. | Epitopes, Malaria Vaccines, Peptide Fragments, Protozoan Proteins, circumsporozoite protein, Protozoan, Interleukin-4, Interferon-gamma, DNA | IM | 8981914, 10.1172/JCI119094, PMC507733, 4860248, 1080789, 4589987, 70310, 3260912, 2646215, 1689762, 1690918, 1988490, 1545867, 1323900, 8423340, 8456302, 8483929, 8350420, 8399489, 8054489, 7937907, 7696207, 7636255, 8596932, 8596933, 8596934, 8610135, 8666919, 8705858, 13099277, 13800711, 4114497 | Plasmid DNA vaccines capable of preventing viral, bacterial, and parasitic infections are currently under development. Our labs have shown that a plasmid DNA vaccine encoding the circumsporozoite protein of the malaria parasite elicits protective immunity against live sporozoite challenge in adult BALB/c mice. We now f... | Age Factors, Amino Acid Sequence, Animals, Cell Count, Cells, Cultured, Cloning, Molecular, DNA, Epitopes, Female, Immune Tolerance, Immunization, Interferon-gamma, Interleukin-4, Malaria Vaccines, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Peptide Fragments, Plasmids, Plasmodium yoelii, Protozoan Proteins, Sp... | null |
8,981,916 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome. | Pitrak D L, Tsai H C, Mullane K M, Sutton S H, Stevens P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Granulocyte Colony-Stimulating Factor, DNA, Ethidium, Acridine Orange | IM | 8981916, 10.1172/JCI119096, PMC507735, 2842409, 3578359, 3058816, 2462934, 2921324, 2477084, 2556018, 1688645, 2642173, 2170609, 1710634, 1676268, 1950799, 1554824, 1809356, 1318327, 1382715, 1400472, 1280481, 8098552, 8388425, 8388903, 8347560, 8409750, 7507846, 7522641, 4179068, 6245367, 7014501, 3900944, 3485396, 34... | Neutrophil (PMNL) function defects occur as a consequence of HIV infection. This study examined PMNL apoptosis in patients with the acquired immunodeficiency syndrome (AIDS) to determine if accelerated apoptosis contributes to impaired function. PMNL were isolated from 10 HIV-infected patients with CD4+ lymphocyte coun... | Acquired Immunodeficiency Syndrome, Acridine Orange, Apoptosis, CD4 Lymphocyte Count, Cell Size, Cell Survival, DNA, Electrophoresis, Agar Gel, Ethidium, Flow Cytometry, Granulocyte Colony-Stimulating Factor, Histocytochemistry, Humans, Microscopy, Electron, Microscopy, Fluorescence, Neutrophils | null |
8,981,915 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study. | Böger R H, Skamira C, Bode-Böger S M, Brabant G, von zur Muhlen A, Frolich J C | eng | null | Clinical Trial, Journal Article, Randomized Controlled Trial | Lipids, Nitrates, Recombinant Proteins, Nitric Oxide, Insulin-Like Growth Factor I, Growth Hormone, Cyclic GMP | IM | 8981915, 10.1172/JCI119095, PMC507734, 6804746, 4369960, 6437507, 2896102, 8174149, 8181036, 8181143, 8187304, 7515738, 8039596, 7918301, 7955442, 7955906, 7964125, 7813598, 7843068, 7843769, 7894657, 7898085, 7721271, 7548389, 7564099, 8616947, 8801862, 8801873, 8548425, 8664144, 8713490, 8772586, 8821467, 2973748, 25... | We studied the effects of recombinant growth hormone on systemic nitric oxide (NO) formation and hemodynamics in a double-blind, placebo-controlled trial in adult patients with acquired growth hormone deficiency. 30 patients were randomly allocated to either recombinant human growth hormone (r-hGH; 2.0 IU/d) or placebo... | Adult, Blood Pressure, Cardiac Output, Cyclic GMP, Female, Growth Hormone, Heart Rate, Humans, Insulin-Like Growth Factor I, Lipids, Male, Nitrates, Nitric Oxide, Recombinant Proteins, Vascular Resistance | null |
8,981,917 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes. | Sakamoto N, Wu C H, Wu G Y | eng | DK-42182 (NIDDK NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | RNA, Catalytic, RNA, Messenger, RNA, Viral, Luciferases | IM | 8981917, 10.1172/JCI119097, PMC507736, 2440339, 2438771, 2468181, 2523562, 2471397, 2569102, 2175903, 1848704, 1658196, 1310759, 1319062, 1472046, 7680362, 8388503, 8210709, 8260875, 8313379, 8135783, 8188703, 8207402, 8030225, 7933114, 7958986, 7983724, 7528330, 7534504, 7743496, 7781762, 7626129, 4705382, 2441261 | To determine the effects of hammerhead ribozymes against hepatitis C virus (HCV) RNA on viral protein translation, a luciferase reporter gene vector, pCMV/T7-NCRCdelta-luc, was constructed containing the 5'-noncoding region (5'-NCR) and part of the core region of HCV. Four ribozymes, Rz1-Rz4, were designed to cleave at... | Cells, Cultured, Electrophoresis, Polyacrylamide Gel, Gene Expression Regulation, Viral, Genes, Reporter, Genetic Therapy, Hepacivirus, Humans, Liver, Luciferases, Nucleic Acid Conformation, Point Mutation, Protein Biosynthesis, RNA, Catalytic, RNA, Messenger, RNA, Viral, Transfection | null |
8,981,918 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist. | Serradeil-Le Gal C, Lacour C, Valette G, Garcia G, Foulon L, Galindo G, Bankir L, Pouzet B, Guillon G, Barberis C, Chicot D, Jard S, Vilain P, Garcia C, Marty E, Raufaste D, Brossard G, Nisato D, Maffrand J P, Le Fur G | eng | null | Journal Article | Antidiuretic Hormone Receptor Antagonists, Benzazepines, Morpholines, Spiro Compounds, Hydrochlorothiazide, Arginine Vasopressin, mozavaptan, Furosemide, Sodium, satavaptan, Adenylyl Cyclases, Potassium | IM | 8981918, 10.1172/JCI119098, PMC507737, 6872945, 6824079, 6699132, 3031358, 7929452, 7805841, 7811254, 7853167, 7867583, 7698346, 7629492, 7631834, 7592759, 7473590, 8549062, 8719042, 8840278, 2964201, 3392884, 2476622, 2687422, 1850553, 1827414, 1852013, 1914197, 1560825, 1534149, 1534150, 1593923, 1387020, 1356229, 13... | SR 121463A, a potent and selective, orally active, nonpeptide vasopressin V2 receptor antagonist, has been characterized in several in vitro and in vivo models. This compound displayed highly competitive and selective affinity for V2 receptors in rat, bovine and human kidney (0.6 < or = Ki [nM] < or = 4.1). In this lat... | Adenylyl Cyclases, Administration, Oral, Adrenal Glands, Animals, Antidiuretic Hormone Receptor Antagonists, Arginine Vasopressin, Autoradiography, Benzazepines, Binding, Competitive, Furosemide, Hydrochlorothiazide, Kidney, Molecular Structure, Morpholines, Potassium, Rats, Sodium, Spiro Compounds, Urine | null |
8,981,919 | 1997-01-30 | 2022-03-17 | 0021-9738 | The Journal of clinical investigation | Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. | Unemori E N, Pickford L B, Salles A L, Piercy C E, Grove B H, Erikson M E, Amento E P | eng | null | Journal Article | Enzyme Precursors, Fibronectins, Procollagen, Recombinant Proteins, Transforming Growth Factor beta, Bleomycin, Relaxin, Collagen, Collagenases, procollagenase | IM | 8981919, 10.1172/JCI119099, PMC507738, 4752894, 1512471, 7416606, 6169174, 2580752, 2993365, 2425458, 3822300, 2446608, 3366935, 2846541, 2475571, 2475572, 1494772, 8370965, 7525651, 7525712, 7653512, 7561646, 8527505, 8550840, 6170243, 2162358, 1695506, 2100192, 1883854, 1892646, 1719696, 1540345, 1312720, 1644255, 89... | Pulmonary fibrosis is the common end stage of a number of pneumopathies. In this study, we examined the ability of the human cytokine, relaxin, to block extracellular matrix deposition by human lung fibroblasts in vitro, and to inhibit lung fibrosis in a bleomycin-induced murine model. In vitro, relaxin (1-100 ng/ml) i... | Animals, Bleomycin, Blotting, Western, Collagen, Collagenases, Disease Models, Animal, Electrophoresis, Polyacrylamide Gel, Enzyme Precursors, Fibronectins, Gene Expression Regulation, Histocytochemistry, Humans, Lung, Lung Injury, Mice, Procollagen, Pulmonary Fibrosis, Recombinant Proteins, Relaxin, Transforming Growt... | null |
8,981,920 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m. | Khare S D, Hansen J, Luthra H S, David C S | eng | AR-39875 (NIAMS NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | DNA Primers, HLA-B27 Antigen, beta 2-Microglobulin | IM | 8981920, 10.1172/JCI119100, PMC507739, 1404160, 1525820, 8326123, 8103147, 8415702, 8228229, 8108441, 8021497, 8026986, 8035391, 8046330, 7930575, 7930576, 7523514, 7964509, 7710096, 7791441, 7612222, 7561043, 7561688, 8568273, 8835511, 4123836, 629602, 6792316, 6358890, 3760563, 2821399, 2467775, 2187471, 2112266, 169... | MHC class I allele, HLA-B27, is strongly associated with a group of human diseases called spondyloarthropathies. Some of these diseases have an onset after an enteric or genitourinary infection. In the present study, we describe spontaneous disease in HLA-B27 transgenic mice where endogenous beta2-microglobulin (beta2m... | Animals, Arthritis, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, DNA Primers, Disease Models, Animal, Electrophoresis, Polyacrylamide Gel, Flow Cytometry, Gene Expression Regulation, HLA-B27 Antigen, Hoof and Claw, Humans, Inflammation, Leukocytes, Major Histocompatibility Complex, Mice, Mice, Transgenic, Mo... | null |
8,981,921 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Muscarinic receptor modulation of basal and beta-adrenergic stimulated function of the failing human left ventricle. | Newton G E, Parker A B, Landzberg J S, Colucci W S, Parker J D | eng | HL-52320 (NHLBI NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Adrenergic beta-Agonists, Receptors, Muscarinic, Dobutamine, Atropine, Acetylcholine | IM | 8981921, 10.1172/JCI119101, PMC507740, 4398792, 3183060, 1245024, 956400, 2916675, 2598435, 2332495, 2337181, 2169357, 2171312, 1901530, 1653121, 1661095, 1551195, 1382385, 8418995, 8391399, 8392548, 8397233, 8376699, 8281643, 7910117, 8023978, 8044956, 7529262, 8595572, 8964109, 7192494, 6299120, 6697466, 3973022, 356... | The objective of this study was to evaluate the effect of muscarinic receptor modulation on basal and beta-adrenergic stimulated left ventricular function in patients with heart failure. 21 heart failure patients and 14 subjects with normal ventricular function were studied. In Protocol 1 intracoronary acetylcholine re... | Acetylcholine, Adrenergic beta-Agonists, Atropine, Catheterization, Dobutamine, Female, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Receptors, Muscarinic | null |
8,981,922 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Differences in endogenous peptides presented by HLA-B*2705 and B*2703 allelic variants. Implications for susceptibility to spondylarthropathies. | Boisgérault F, Tieng V, Stolzenberg M C, Dulphy N, Khalil I, Tamouza R, Charron D, Toubert A | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antibodies, Monoclonal, HLA Antigens, HLA-B27 Antigen, Peptide Fragments | IM | 8981922, 10.1172/JCI119102, PMC507741, 1671992, 2342577, 1922338, 1541831, 1327802, 8436905, 8473755, 8415702, 8225441, 8124703, 8191286, 7523146, 7964509, 7846047, 7863326, 7889404, 7895159, 7722439, 7761976, 7791441, 7612222, 7612235, 7664799, 7547104, 7561688, 7594476, 7489765, 7482491, 7500030, 8598039, 8617941, 86... | The association between HLA-B27 and spondylarthropathies is currently being reinvestigated in the light of HLA-B27 subtyping. At least 11 different subtypes have been described among which B*2703, B*2706, and B*2709 could be less closely associated with disease at the population level. Differences in the presentation o... | Amino Acid Sequence, Antibodies, Monoclonal, Autoimmunity, B-Lymphocytes, Binding Sites, Chromatography, High Pressure Liquid, Fluorescence, HLA Antigens, HLA-B27 Antigen, Humans, Molecular Sequence Data, Peptide Fragments, Protein Binding, Sequence Analysis, Spondylitis, Ankylosing, Transfection | null |
8,981,923 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. | Mallat A, Préaux A M, Serradeil-Le Gal C, Raufaste D, Gallois C, Brenner D A, Bradham C, Maclouf J, Iourgenko V, Fouassier L, Dhumeaux D, Mavier P, Lotersztajn S | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Endothelin-1, Prostaglandins, RNA, Messenger, Receptor, Endothelin B, Receptors, Endothelin, Viper Venoms, sarafotoxins s6, Colforsin, carboprostacyclin, Epoprostenol, Cyclic AMP, Protein Kinases, Adenylyl Cyclases, Ibuprofen | IM | 8981923, 10.1172/JCI119103, PMC507742, 3898913, 2440339, 2451132, 2513128, 8016110, 8031866, 7518515, 8073500, 7929360, 7943321, 7982659, 7527398, 7992057, 7855889, 7860764, 7864140, 7878738, 7705772, 7709430, 7777549, 7615814, 7622446, 7625997, 7625999, 7629120, 7629196, 7565768, 7481820, 8524841, 8550585, 8566602, 87... | During chronic liver diseases, hepatic stellate cells (HSC) acquire an activated myofibroblast-like phenotype, proliferate, and synthetize fibrosis components. We have shown that endothelin-1 (ET-1) inhibits the proliferation of activated human HSC via endothelin B (ETB) receptors. We now investigate the transduction p... | Adenylyl Cyclases, Adipocytes, Binding Sites, Cell Division, Cells, Cultured, Colforsin, Cyclic AMP, Endothelin-1, Epoprostenol, Genes, jun, Humans, Ibuprofen, Liver, Prostaglandins, Protein Kinases, RNA, Messenger, Receptor, Endothelin B, Receptors, Endothelin, Up-Regulation, Viper Venoms | null |
8,981,924 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors. | Bong G W, Rosengren S, Firestein G S | eng | null | Journal Article | Anti-Inflammatory Agents, Excitatory Amino Acid Antagonists, Phenethylamines, Propionates, Purinergic P1 Receptor Antagonists, Receptors, Glutamate, Receptors, N-Methyl-D-Aspartate, Receptors, Purinergic P1, 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine, Adenosine-5'-(N-ethylcarboxamide), 3,7-dime... | IM | 8981924, 10.1172/JCI119104, PMC507743, 8380395, 7522223, 1347551, 1704282, 1361220, 2556044, 7662029, 2323375, 8018857, 8102041, 1472964, 7602536, 14677603, 1963110, 2451003, 2907698, 3010074, 3431917, 7730646, 7680175, 2558391, 1358641, 6142434, 2194223, 1448186, 6100110, 12106256, 6149943, 2906426, 2600819, 7904298, ... | The effect of spinal adenosine receptor ligation on peripheral leukocyte accumulation was studied in two rat models of inflammation. Neutrophil infiltration into dermal inflammatory sites was signficantly reduced by adenosine A1 receptor agonists injected through intrathecal catheters. These effects were reversed by N-... | 6-Cyano-7-nitroquinoxaline-2,3-dione, Adenosine, Adenosine-5'-(N-ethylcarboxamide), Animals, Anti-Inflammatory Agents, Carrageenan, Catheterization, Central Nervous System, Dexamethasone, Excitatory Amino Acid Antagonists, Inflammation, N-Methylaspartate, Neutrophils, Peroxidase, Phenethylamines, Propionates, Purinergi... | null |
8,981,925 | 1997-01-30 | 2022-03-30 | 0021-9738 | The Journal of clinical investigation | Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. | Redmon J B, Olson L K, Armstrong M B, Greene M J, Robertson R P | eng | K08-DK02134 (NIDDK NIH HHS, United States); R01-DK38325 (NIDDK NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, P.H.S. | Calmodulin-Binding Proteins, Immunosuppressive Agents, Insulin, RNA, Messenger, Chloramphenicol O-Acetyltransferase, Calcineurin, Phosphoprotein Phosphatases, Tacrolimus | IM | 8981925, 10.1172/JCI119105, PMC507744, 4551514, 7689268, 7052089, 2997172, 3902821, 2442255, 3071361, 2771659, 2808335, 1979979, 1702904, 1702911, 1703352, 1848110, 1710218, 1682135, 1935821, 1721286, 1721372, 1721391, 1721395, 1371575, 1373536, 1809963, 1374016, 7691065, 7693684, 7694879, 7907998, 7520433, 7926339, 78... | FK506 (tacrolimus) is an immunosuppressive drug which interrupts Ca2+-calmodulin-calcineurin signaling pathways in T lymphocytes, thereby blocking antigen activation of T cell early activation genes. Regulation of insulin gene expression in the beta cell may also involve Ca2+-signaling pathways and FK506 has been assoc... | Blotting, Northern, Blotting, Western, Calcineurin, Calmodulin-Binding Proteins, Cells, Cultured, Chloramphenicol O-Acetyltransferase, Gene Expression Regulation, Genes, Reporter, Humans, Immunosuppressive Agents, Insulin, Insulin Secretion, Islets of Langerhans, Phosphoprotein Phosphatases, RNA, Messenger, Tacrolimus,... | null |
8,981,926 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation. | Kohsaka H, Carson D A, Rassenti L Z, Ollier W E, Chen P P, Kipps T J, Miyasaka N | eng | AR-25443 (NIAMS NIH HHS, United States); AR-41897 (NIAMS NIH HHS, United States); CA-49870 (NCI NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | DNA Probes, Immunoglobulin G, Immunoglobulin M, Immunoglobulin Variable Region | IM | 8981926, 10.1172/JCI119106, PMC507745, 8454861, 8454853, 8099917, 8344352, 8228225, 8233786, 8301127, 7514412, 8200991, 7920635, 7921761, 7759877, 7779254, 7631137, 7631158, 7486533, 7486537, 7486567, 8621797, 3118465, 3358796, 2170112, 2130118, 2130119, 2130120, 1717620, 1940794, 1740665, 1588274, 1404388, 1438230, 13... | The factors controlling immunoglobulin (Ig) gene repertoire formation are poorly understood. Studies on monozygotic twins have helped discern the contributions of genetic versus environmental factors on expressed traits. In the present experiments, we applied a novel anchored PCR-ELISA system to compare the heavy chain... | Adult, Aged, Arthritis, Autoimmunity, B-Lymphocytes, DNA Probes, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation, Humans, Immunoglobulin G, Immunoglobulin M, Immunoglobulin Variable Region, Male, Middle Aged, Polymerase Chain Reaction, Sequence Analysis, Transcription, Genetic, Twins, Monozygotic | null |
8,981,927 | 1997-01-30 | 2020-12-22 | 0021-9738 | The Journal of clinical investigation | Long-lived and transferable tumor immunity in mice after targeted interleukin-2 therapy. | Becker J C, Varki N, Gillies S D, Furukawa K, Reisfeld R A | eng | CA-42508 (NCI NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Antibodies, Gangliosides, Interleukin-2, Recombinant Fusion Proteins | IM | 8981927, 10.1172/JCI119107, PMC507746, 6981814, 7777545, 3264384, 2514231, 2196590, 1831615, 1916847, 7612229, 7543536, 7547695, 8642346, 8755561, 1741398, 8439974, 7904900, 8293465, 7937974, 7826525, 7848515, 7897222, 7741031, 3793267 | A major goal of tumor immunotherapy is the induction of tumor-specific T cell responses that are effective in eradicating disseminated tumor, as well as mounting a persistent tumor-protective immunity. We demonstrate here that a genetically engineered fusion protein consisting of human/mouse chimeric anti-ganglioside G... | Animals, Antibodies, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Gangliosides, Immunity, Immunohistochemistry, Immunotherapy, Interleukin-2, Melanoma, Mice, Mice, SCID, Neoplasm Metastasis, Neoplasms, Experimental, Recombinant Fusion Proteins, Tumor Cells, Cultured | null |
8,981,928 | 1997-01-30 | 2018-12-17 | 0021-9738 | The Journal of clinical investigation | Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. | Ling Z, Pipeleers D G | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Insulin, Proteins, Tyrosine, DNA, Glucose | IM | 8981928, 10.1172/JCI119108, PMC507747, 8420817, 1425483, 8307250, 7515006, 8070607, 7821725, 7821741, 7635965, 7593639, 4613593, 6134752, 6203798, 2862019, 3512603, 2422950, 2941762, 2452071, 3287379, 2535989, 2684709, 2559866, 2204282, 2226113, 2254465, 1729264, 1548342, 1532777, 1612191, 1612193, 1400446, 1401063, 83... | Human beta cells can be maintained in serum-free culture at 6 mmol/liter glucose, with 80% cell recovery and preserved glucose-inducible functions after 1 wk. Between 0 and 10 mmol/liter, glucose dose-dependently increases the number of beta cells in active protein synthesis (15% at 0 mmol/liter glucose, 60% at 5 mmol/... | Analysis of Variance, Cells, Cultured, DNA, Glucose, Humans, Immunohistochemistry, Insulin, Insulin Secretion, Islets of Langerhans, Proteins, Tyrosine | null |
8,981,929 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | An N-linked high-mannose type oligosaccharide, expressed at the major outer membrane protein of Chlamydia trachomatis, mediates attachment and infectivity of the microorganism to HeLa cells. | Kuo C, Takahashi N, Swanson A F, Ozeki Y, Hakomori S | eng | CA-42505 (NCI NIH HHS, United States); EY-00219 (NEI NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, P.H.S. | Bacterial Outer Membrane Proteins, Glycopeptides, Mannosides, Polysaccharides, Bacterial, Porins, omp1 protein, Chlamydia trachomatis, Ovalbumin, Amidohydrolases, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase | IM | 8981929, 10.1172/JCI119109, PMC507748, 4718924, 179950, 62678, 7048000, 7141712, 7152681, 6841322, 4055037, 3407923, 3149518, 2298489, 2373685, 1645328, 1724547, 8335979, 8262634, 7494492 | The structure of the carbohydrate of the 40-kD major outer membrane component of Chlamydia trachomatis and its role in defining infectivity of the organism were investigated. The oligosaccharides were released from the glycoprotein by N-glycanase digestion, coupled to a 2-aminopyridyl residue, and subjected to two-dime... | Amidohydrolases, Bacterial Adhesion, Bacterial Outer Membrane Proteins, Carbohydrate Conformation, Carbohydrate Sequence, Chlamydia trachomatis, Chromatography, Chromatography, Affinity, Glycopeptides, HeLa Cells, Humans, Mannosides, Molecular Sequence Data, Molecular Structure, Ovalbumin, Peptide-N4-(N-acetyl-beta-glu... | null |
8,981,930 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells. | Wing M G, Moreau T, Greenwood J, Smith R M, Hale G, Isaacs J, Waldmann H, Lachmann P J, Compston A | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm, CD11 Antigens, Cytokines, Immunoglobulin G, Immunoglobulin M, Interleukin-6, Receptors, IgG, Tumor Necrosis Factor-alpha, Alemtuzumab, Interferon-gamma | IM | 8981930, 10.1172/JCI119110, PMC507749, 2904526, 3262381, 2713487, 2786029, 7879212, 7718516, 8624684, 2500254, 2532305, 2109379, 2358784, 2366834, 2165283, 1700001, 2122929, 2253684, 2148808, 1824981, 1999225, 1856593, 1833456, 1533898, 1534096, 1356177, 8477804, 8099991, 8344347, 8363726, 8200988, 8009586, 7914262, 20... | The administration of the immunosuppressive humanized monoclonal antibody CAMPATH 1-H, which recognizes CD52 on lymphocytes and monocytes, is associated with a first-dose cytokine-release syndrome involving TNFalpha, IFNgamma, and IL-6 clinically. In vitro models have been used to establish the cellular source and mech... | Alemtuzumab, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm, CD11 Antigens, CD4-Positive T-Lymphocytes, Cytokines, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin G, Immunoglobulin M, Interferon-gamma, Interleukin-6, Killer Cells, Natural, Leukocytes, Receptors, IgG, Tumor Nec... | null |
8,981,932 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Congenital hypothyroid goiter with deficient thyroglobulin. Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones. | Medeiros-Neto G, Kim P S, Yoo S E, Vono J, Targovnik H M, Camargo R, Hossain S A, Arvan P | eng | DK-02113 (NIDDK NIH HHS, United States); DK-40344 (NIDDK NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | HSP70 Heat-Shock Proteins, Membrane Proteins, Molecular Chaperones, glucose-regulated proteins, Thyrotropin, Thyroglobulin | IM | 8981932, 10.1172/JCI119112, PMC507751, 7822419, 8373082, 3624800, 8513503, 7593451, 1714445, 2460739, 2061316, 1400441, 1772654, 8626865, 8325250, 2924725, 8470055, 8366105, 8625414, 8636208, 1470006, 1384031, 3084497, 3472203, 1991788, 14731479, 2882514, 3304148, 1373378, 8214027, 8358794, 1563355, 7790376, 8636228, 8... | Recent advances in understanding the molecular pathogenesis of congenital hypothyroid goiter in cog/cog mice, have raised important questions concerning the maturation of thyroglobulin (the thyroid prohormone) in certain human kindreds with congenital goiter. We have now examined affected siblings from two unrelated fa... | Animals, Electrophoresis, Polyacrylamide Gel, Endoplasmic Reticulum, Gene Expression Regulation, Glycosylation, Goiter, HSP70 Heat-Shock Proteins, Humans, Hypothyroidism, Immunoassay, Immunoblotting, Immunohistochemistry, Membrane Proteins, Mice, Mice, Inbred Strains, Microscopy, Electron, Molecular Chaperones, Mutatio... | null |
8,981,931 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Repertoire cloning of lupus anti-DNA autoantibodies. | Roben P, Barbas S M, Sandoval L, Lecerf J M, Stollar B D, Solomon A, Silverman G J | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Antibodies, Antinuclear, Autoantibodies, DNA-Binding Proteins, Immunoglobulin Fab Fragments, Immunoglobulin Idiotypes, Immunoglobulin Variable Region, Recombinant Proteins, DNA | IM | 8981931, 10.1172/JCI119111, PMC507750, 4168098, 1431128, 303258, 7463697, 3760566, 3553329, 2441044, 3681981, 3396540, 3263866, 2785132, 2497186, 2786910, 2295800, 2107394, 2640629, 1696733, 2212009, 2120334, 2124678, 1826052, 2562243, 1903540, 8459218, 8478936, 7683424, 8496598, 8704103, 8098941, 7686009, 7688492, 836... | To investigate the autoantibody repertoire associated with SLE, we have created phage display IgG Fab libraries from two clinically active SLE patients and from the healthy identical twin of one of these patients. The libraries from the lupus discordant twins were found to both include unusually large representations o... | Amino Acid Sequence, Antibodies, Antinuclear, Autoantibodies, Autoimmunity, B-Lymphocytes, Cloning, Molecular, DNA, DNA-Binding Proteins, Female, Genes, Humans, Immunoglobulin Fab Fragments, Immunoglobulin Idiotypes, Immunoglobulin Variable Region, Lupus Erythematosus, Systemic, Molecular Sequence Data, Nucleic Acid Hy... | null |
8,981,933 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. | Tang W, Geba G P, Zheng T, Ray P, Homer R J, Kuhn C, Flavell R A, Elias J A | eng | AI-34593 (NIAID NIH HHS, United States); HL-36708 (NHLBI NIH HHS, United States); HL-54989 (NHLBI NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, P.H.S. | Interleukin-11, Proteins, SCGB1A1 protein, human, Scgb1a1 protein, mouse, Methacholine Chloride, Uteroglobin | IM | 8981933, 10.1172/JCI119113, PMC507752, 2457008, 7962549, 1542323, 1502977, 7904069, 8551213, 1586873, 8368645, 1734808, 8238534, 1530960, 2361391, 7700748, 13508884, 7735629, 7963541, 8133053, 8244270, 7512836, 7611596, 8567963, 7743829, 8145045, 2223105, 2798426, 835591, 8071352, 7767192, 8314838, 8430954, 8613544, 15... | Interleukin-11 is a pleotropic cytokine produced by lung stromal cells in response to respiratory viruses, cytokines, and histamine. To further define its potential effector functions, the Clara cell 10-kD protein promoter was used to express IL-11 and the airways of the resulting transgene mice were characterized. In ... | Airway Obstruction, Airway Resistance, Animals, Blotting, Northern, Blotting, Southern, Cloning, Molecular, Disease Models, Animal, Gene Expression Regulation, Histocytochemistry, Immunohistochemistry, Interleukin-11, Lung, Methacholine Chloride, Mice, Mice, Transgenic, Microscopy, Electron, Promoter Regions, Genetic, ... | null |
8,981,934 | 1997-01-30 | 2022-03-17 | 0021-9738 | The Journal of clinical investigation | Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death. | Krown K A, Page M T, Nguyen C, Zechner D, Gutierrez V, Comstock K L, Glembotski C C, Quintana P J, Sabbadini R A | eng | 2SO6 GM-45765 (NIGMS NIH HHS, United States); HL-25073 (NHLBI NIH HHS, United States); HL-46345 (NHLBI NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, P.H.S. | Benzoxazoles, Ceramides, Quinolinium Compounds, Sphingolipids, Tumor Necrosis Factor-alpha, 1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium, Hydrogen Peroxide, Sphingosine | IM | 8981934, 10.1172/JCI119114, PMC507753, 1508712, 6477583, 8521959, 7867010, 7511048, 1349327, 8609343, 7778672, 8335952, 8637856, 8027608, 7664414, 8051401, 8140617, 2195340, 7955152, 7644533, 7877644, 8390056, 8456305, 8512573, 7520371, 7878464, 7644501, 7654318, 3345800, 1376309, 7511719, 2732671, 8294493, 7635940, 76... | In the present study, it was shown that physiologically relevant levels of the proinflammatory cytokine TNFalpha induced apoptosis in rat cardiomyocytes in vitro, as quantified by single cell microgel electrophoresis of nuclei ("cardiac comets") as well as by morphological and biochemical criteria. It was also shown th... | Analysis of Variance, Animals, Apoptosis, Benzoxazoles, Cell Nucleus, Cells, Cultured, Ceramides, DNA Damage, Electrophoresis, Agar Gel, Hydrogen Peroxide, Image Processing, Computer-Assisted, Microscopy, Fluorescence, Myocardial Ischemia, Myocardium, Quinolinium Compounds, Rats, Signal Transduction, Sphingolipids, Sph... | null |
8,981,935 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome. | Sata M, Ikebe M | eng | AR41653 (NIAMS NIH HHS, United States); HL47530 (NHLBI NIH HHS, United States); HL56218 (NHLBI NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Actins, DNA Primers, DNA, Complementary, Myosin Light Chains, Recombinant Proteins, Adenosine Triphosphatases, Myosins | IM | 8981935, 10.1172/JCI119115, PMC507754, 4254541, 3547135, 2440339, 2969919, 3417683, 8611530, 8780515, 2466845, 2704627, 2614840, 2362820, 1975517, 2249844, 1552912, 1638703, 8509418, 8514894, 8316857, 8316858, 8370124, 8281650, 8282798, 8294404, 8182105, 7805259, 7731997, 7614728, 7619795, 7648684, 8618824, 8614836, 47... | More than 30 missense mutations in the beta-cardiac myosin heavy chain gene have been shown to be responsible for familial hypertrophic cardiomyopathy. To clarify the effects of these point mutations on myosin motor function, we expressed wild-type and mutant human beta-cardiac myosin heavy chains in insect cells with ... | Actins, Adenosine Triphosphatases, Baculoviridae, Binding Sites, Cardiomyopathies, Cloning, Molecular, DNA Primers, DNA, Complementary, Electrophoresis, Polyacrylamide Gel, Gene Expression, Genetic Vectors, Humans, Models, Molecular, Myocardium, Myosin Light Chains, Myosins, Point Mutation, Recombinant Proteins, Struct... | null |
8,981,939 | 1997-01-23 | 2020-08-24 | 0002-9297 | American journal of human genetics | 1996 ASHG Presidential Address. Toward the 21st century. | Epstein C J | eng | null | Address | null | IM | 8981939, PMC1712556, 7500515, 8250037, 7477396, 7500511 | null | Forecasting, Genetics, Medical, Humans, Science, Sociology | null |
8,981,937 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects. | Federici M, Zucaro L, Porzio O, Massoud R, Borboni P, Lauro D, Sesti G | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Insulin, Insulin-Like Growth Factor I, Receptor, IGF Type 1, Receptor, Insulin | IM | 8981937, 10.1172/JCI119117, PMC507756, 942051, 8522066, 2859121, 3894418, 3525587, 3021758, 2877871, 2435731, 3033021, 2824266, 3289989, 2645308, 2722845, 2546949, 2480779, 2557329, 1698059, 2211678, 1535055, 1469083, 8452530, 8463272, 8325952, 8227340, 8250456, 7895674, 7720646, 7781591, 7796985, 2983222 | Insulin receptors (IR) and IGF-I receptors (IGF-IR) have been shown to form hybrid receptors in tissues coexpressing both molecules. To date there is no information about the distribution of hybrids in tissues of normal or diabetic subjects. We developed a microwell-based immunoassay to quantitate hybrids in small huma... | Binding, Competitive, Blotting, Western, Diabetes Mellitus, Type 2, Humans, Immunoassay, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Muscle, Skeletal, Protein Conformation, Receptor, IGF Type 1, Receptor, Insulin | null |
8,981,938 | 1997-01-30 | 2022-03-09 | 0021-9738 | The Journal of clinical investigation | Particle-mediated gene transfer with transforming growth factor-beta1 cDNAs enhances wound repair in rat skin. | Benn S I, Whitsitt J S, Broadley K N, Nanney L B, Perkins D, He L, Patel M, Morgan J R, Swain W F, Davidson J M | eng | AG-06528 (NIA NIH HHS, United States); AR-41943 (NIAMS NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S. | DNA, Complementary, Transforming Growth Factor beta, alpha 1-Antitrypsin | IM | 8981938, 10.1172/JCI119118, PMC507757, 7798248, 7991604, 7849530, 7708743, 4170654, 5544593, 225559, 6426853, 3877308, 2424019, 2440339, 2442813, 3498859, 2461367, 3237091, 2708352, 2736960, 2137615, 1690918, 2350783, 2395327, 2119055, 2175906, 1654338, 1793583, 1314170, 1606665, 1322148, 8421714, 2562644, 8382374, 845... | Based on preliminary but variable results with direct DNA transfer into wounds, we evaluated in vivo gene transfer by particle-mediated DNA delivery to rat skin to determine whether overexpression of TGF-beta1 at the site of skin incisions would result in a significant improvement in repair. Optimization of the method ... | Animals, Biolistics, Blotting, Southern, DNA, Complementary, Diabetes Mellitus, Gene Expression Regulation, Gene Transfer Techniques, Genes, Reporter, HeLa Cells, Humans, Immunohistochemistry, Keratinocytes, Polymerase Chain Reaction, Promoter Regions, Genetic, Rats, Skin, Transforming Growth Factor beta, Wound Healing... | null |
8,981,936 | 1997-01-30 | 2018-11-13 | 0021-9738 | The Journal of clinical investigation | Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels. | Balser J R, Nuss H B, Orias D W, Johns D C, Marban E, Tomaselli G F, Lawrence J H | eng | K11 HL02639 (NHLBI NIH HHS, United States); R01 HL50411 (NHLBI NIH HHS, United States); R01 HL52768 (NHLBI NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Anesthetics, Local, Sodium Channels, Lidocaine | IM | 8981936, 10.1172/JCI119116, PMC507755, 5112659, 1375395, 4541340, 1081138, 300786, 334262, 21711, 591912, 271968, 306437, 687766, 728531, 6264305, 233568, 6270629, 6306139, 6207484, 6094703, 3881765, 2446150, 2448487, 3323813, 2458625, 2543931, 1321496, 1668345, 1332059, 1332060, 14343300, 7683789, 8391996, 8396459, 81... | Time- and voltage-dependent local anesthetic effects on sodium (Na) currents are generally interpreted using modulated receptor models that require formation of drug-associated nonconducting states with high affinity for the inactivated channel. The availability of inactivation-deficient Na channels has enabled us to t... | Allosteric Regulation, Anesthetics, Local, Animals, Cloning, Molecular, Electrophysiology, Lidocaine, Microinjections, Muscle, Skeletal, Mutagenesis, Site-Directed, Oocytes, Patch-Clamp Techniques, Rats, Sodium Channels, Xenopus | null |
8,981,940 | 1997-01-23 | 2020-08-24 | 0002-9297 | American journal of human genetics | Variable expressivity of patched mutations in flies and humans. | Bale A E | eng | null | Editorial | Drosophila Proteins, Hedgehog Proteins, Insect Hormones, Membrane Proteins, Patched Receptors, Proteins, Receptors, Cell Surface, Trans-Activators, ptc protein, Drosophila, hh protein, Drosophila | IM | 8981940, PMC1712536, 4960000, 5279523, 332332, 7446524, 2081453, 1910262, 1347096, 1347116, 1348213, 8483937, 8488837, 8042672, 7712637, 7743921, 7577671, 8528259, 8658128, 8681379, 8755929, 8782823 | null | Animals, Basal Cell Nevus Syndrome, Drosophila, Drosophila Proteins, Germ-Line Mutation, Hedgehog Proteins, Humans, Insect Hormones, Membrane Proteins, Patched Receptors, Proteins, Receptors, Cell Surface, Trans-Activators | null |
8,981,941 | 1997-01-23 | 2020-08-24 | 0002-9297 | American journal of human genetics | Using genetics to dissect cognition. | Pennington B F | eng | null | Comment, Editorial | null | IM | 8981941, PMC1712539, 4170865, 6828864, 2083497, 7939663, 7751558, 8981944, 14846691 | null | Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 6, Cognition, Dyslexia, Genetic Linkage, Humans, Speech, Visual Perception | null |
8,981,942 | 1997-01-23 | 2020-08-24 | 0002-9297 | American journal of human genetics | Empirical evidence that genetic counseling is directive: where do we go from here? | Bernhardt B A | eng | null | Editorial, Comment | null | IM | 8981942, PMC1712550, 8981945, 11654229, 11651283, 11651279, 11657407, 7645300, 1681352, 8500262, 8153035, 7801980, 3348219 | null | Genetic Counseling, Humans, Person-Centered Psychotherapy | null |
8,981,943 | 1997-01-23 | 2020-11-13 | 0002-9297 | American journal of human genetics | Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident. | Wicking C, Shanley S, Smyth I, Gillies S, Negus K, Graham S, Suthers G, Haites N, Edwards M, Wainwright B, Chenevix-Trench G | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Membrane Proteins, PTCH1 protein, human, Patched Receptors, Patched-1 Receptor, Receptors, Cell Surface | IM | 8981943, PMC1712561, 3547011, 1650914, 1653906, 1594239, 8326488, 8287482, 8306973, 8145818, 8042673, 8049467, 8075640, 8001963, 7493024, 8595881, 8647801, 8658145, 8681379, 8755919, 6209716 | The human homologue of the Drosophila segment polarity gene patched is implicated in the development of nevoid basal cell carcinoma syndrome (NBCCS) and in the genesis of sporadic basal cell carcinomas. In order to examine the phenotypic variability in NBCCS and to highlight functionally important domains of the PTCH p... | Basal Cell Nevus Syndrome, Exons, Female, Genotype, Germ-Line Mutation, Humans, Male, Membrane Proteins, Molecular Sequence Data, Mosaicism, Patched Receptors, Patched-1 Receptor, Pedigree, Phenotype, Polymorphism, Single-Stranded Conformational, Receptors, Cell Surface, Transcription, Genetic | null |
8,981,944 | 1997-01-23 | 2020-08-24 | 0002-9297 | American journal of human genetics | Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. | Grigorenko E L, Wood F B, Meyer M S, Hart L A, Speed W C, Shuster A, Pauls D L | eng | HD21887 (NICHD NIH HHS, United States); MH00508 (NIMH NIH HHS, United States); MH39239 (NIMH NIH HHS, United States) | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S. | Genetic Markers | IM | 8981944, PMC1712535, 6828864, 7425998, 6614001, 6616125, 6587361, 3741977, 3652490, 3657975, 3422543, 3344216, 3359167, 2465364, 2929597, 2703785, 2794763, 2589323, 2376893, 2377495, 2076492, 2017389, 2020562, 1861069, 1880884, 8101276, 8352272, 8314032, 8314036, 8006506, 8016089, 7545953, 4765237, 1158987, 7939663, 78... | Six extended dyslexic families with at least four affected individuals were genotyped with markers in three chromosomal regions: 6p23-p21.3, 15pter-qter, and 16pter-qter. Five theoretically derived phenotypes were used in the linkage analyses: (1) phonological awareness; (2) phonological decoding; (3) rapid automatized... | Adolescent, Adult, Chromosome Mapping, Chromosomes, Human, Pair 15, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 6, Dyslexia, Female, Genetic Linkage, Genetic Markers, Genetic Predisposition to Disease, Humans, Male, Pedigree | null |
8,981,945 | 1997-01-23 | 2020-08-24 | 0002-9297 | American journal of human genetics | Nondirectiveness in genetic counseling: an empirical study. | Michie S, Bron F, Bobrow M, Marteau T M | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 8981945, PMC1712566, 7241540, 6743923, 4031436, 3815882, 3348219, 1971875, 2282112, 1877608, 1393159, 7589944, 474624, 455018, 11651283, 11657407, 11653028, 843571, 874463 | Nondirectiveness is considered an essential part of genetic counseling, yet there is no generally accepted definition nor data documenting its impact on counselees. This study is an empirical investigation of directiveness, using ratings from transcripts of consultations and comparing these with counselor-reported and ... | Genetic Counseling, Humans, Person-Centered Psychotherapy | null |
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