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10.1101/19000273 | Crohns disease and ulcerative colitis patient perspectives on clinical trials and participation | Orna G Ehrlich; James Testaverde; Caren Heller; Stuart Daman; Annick Anderson; Peter D.R. Higgins | Orna G Ehrlich | Crohn\'s & Colitis Foundation | 2019-06-25 | 1 | cc_by_nc_nd | gastroenterology | https://www.medrxiv.org/content/early/2019/06/25/19000273.source.xml | BackgroundClinical trial recruitment is often the rate-limiting step in the development of new treatments reaching patients across all disease states. With more than 1500 currently available clinical trials for inflammatory bowel diseases (IBD) patients, it is important to understand patient perceptions of clinical tri... | 10.1053/j.gastro.2017.11.058 | medrxiv | 1 | |
10.1101/19000463 | Updating Insights into Rosiglitazone and Cardiovascular Risk through Shared Data: Individual Patient-and-Summary-Level Meta-Analyses | Joshua D Wallach; Kun Wang; Audrey D Zhang; Deanna Chang; Holly K Grossetta Nardini; Haiqun Lin; Michael B Bracken; Mayur Desai; Harlan Krumholz; Joseph S. Ross | Joshua D Wallach | Yale School of Public Health | 2019-06-25 | 1 | cc_by_nc | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/06/25/19000463.source.xml | ObjectiveTo conduct a systematic review and meta-analysis of the effects of rosiglitazone therapy on cardiovascular risk and mortality using multiple data sources and varying analytical approaches.
DesignSystematic review and meta-analysis of randomized controlled trials.
Data sourcesGlaxoSmithKlines (GSK) Clinical S... | 10.1136/bmj.l7078 | medrxiv | 2 | |
10.1101/19000430 | Predicting epileptic seizures using nonnegative matrix factorization | Olivera Stojanovic; Gordon Pipa | Olivera Stojanovic | Institute of Cognitive Science, University of Osnabrueck | 2019-06-25 | 1 | cc_by | health informatics | https://www.medrxiv.org/content/early/2019/06/25/19000430.source.xml | This paper presents a procedure for the patient-specific prediction of epileptic seizures. To this end, a combination of nonnegative matrix factorization (NMF) and smooth basis functions with robust regression is applied to power spectra of intracranial electroencephalographic (iEEG) signals. The resulting time and fre... | 10.1371/journal.pone.0228025 | medrxiv | 3 | |
10.1101/19000133 | Prospective and External Evaluation of a Machine Learning Model to Predict In-Hospital Mortality | Nathan Brajer; Brian Cozzi; Michael Gao; Mike Revoir; Marshall Nichols; Joseph Futoma; Jonathan Bae; Noppon Setji; Suresh Balu; Adrian Hernandez; Mark Sendak | Nathan Brajer | Duke University School of Medicine | 2019-06-25 | 1 | cc_by_nc_nd | health systems and quality improvement | https://www.medrxiv.org/content/early/2019/06/25/19000133.source.xml | The ability to accurately predict in-hospital mortality for patients at the time of admission could improve clinical and operational decision-making and outcomes. Few machine learning models have been developed to predict in-hospital death that are both broadly applicable to all adult patients across a health system an... | 10.1001/jamanetworkopen.2019.20733 | medrxiv | 4 | |
10.1101/19000596 | 18F-AV1451 PET imaging and white matter changes in progressive supranuclear palsy | Nicolas Nicastro; Patricia Vazquez Rodriguez; Maura Malpetti; W. Richard Bevan-Jones; P. Simon Jones; Luca Passamonti; Franklin I Aigbirhio; John T O'Brien; James B Rowe | Nicolas Nicastro | University of Cambridge | 2019-06-25 | 1 | cc_by_nc_nd | neurology | https://www.medrxiv.org/content/early/2019/06/25/19000596.source.xml | IntroductionProgressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter of deep nuclei and cerebellum. White matter changes are increasingly documented as a feature of degenerative parkinsonism. We therefore examined the relationship between tau pathology (... | 10.1007/s00415-019-09566-9 | medrxiv | 6 | |
10.1101/19000265 | Perception of whole-body motion during balance perturbations is impaired in Parkinson's disease and is associated with balance impairment | Sistania M Bong; JL McKay; Stewart A Factor; Lena H Ting | Lena H Ting | Emory University | 2019-06-25 | 1 | cc_by | neurology | https://www.medrxiv.org/content/early/2019/06/25/19000265.source.xml | BackgroundIn addition to motor deficits, Parkinsons disease (PD) may cause perceptual impairments. The role of perceptual impairments in sensorimotor function is unclear, and has typically been studied in single-joint motions. Research Question: We hypothesized that perception of whole-body motion is impaired in PD and... | 10.1016/j.gaitpost.2019.10.029 | medrxiv | 7 | |
10.1101/19000638 | Transfer of Statistical Innovations of the 1990s-2000s in Oncology to the Biomedical Literature | Alexandre Vivot; Vincent Levy; Sylvie Chevret | Alexandre Vivot | APHP | 2019-06-25 | 1 | cc_no | oncology | https://www.medrxiv.org/content/early/2019/06/25/19000638.source.xml | IntroductionInnovations in the fields of clinical studies require time to generate and disseminate new knowledge. We aimed to specifically explore lag times between the introduction and widespread use of innovative statistical methods in oncology using the competing risks and phase I model-based clinical trials setting... | NA | medrxiv | 9 | |
10.1101/19000174 | Histopathologist Features Predictive of Diagnostic Concordance at Expert Level Amongst a Large International Sample of Pathologists Diagnosing Barrett′s Dysplasia Using Digital Pathology | Myrtle J Van der Wel; Helen G Coleman; Jacques JGHM Bergman; Marnix Jansen; Sybren L Meijer | Marnix Jansen | UCL Cancer Institute | 2019-06-25 | 1 | cc_no | oncology | https://www.medrxiv.org/content/early/2019/06/25/19000174.source.xml | ObjectiveGuidelines recommend expert pathology review of Barretts oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance amongst a large internatio... | 10.1136/gutjnl-2019-318985 | medrxiv | 10 | |
10.1101/19000166 | Gait differences in patients with multiple sclerosis who have low and high levels of disability. | John J Fraser; Jeannie Stephensen | John J Fraser | Physical Therapy Program, Department of Biology, The College of Staten Island City University of New York, Staten Island, NY | 2019-06-25 | 1 | cc0 | rehabilitation medicine and physical therapy | https://www.medrxiv.org/content/early/2019/06/25/19000166.source.xml | BackgroundMultiple Sclerosis (MS) often results in gait impairment and disability.
ObjectiveTo investigate differences in spatiotemporal gait characteristics of people with MS who have low versus high levels of disability. Between trial and inter-limb consistency and the association of gait variables with level of dis... | NA | medrxiv | 13 | |
10.1101/19000356 | Metabolomics in juvenile-onset SLE: identifying new biomarkers to predict cardiovascular risk | George A Robinson; Leda Coelewij; Ania Radziszewska; Chris Wincup; Hannah Peckham; Kirsty Waddington; David A Isenberg; Yiannis Ioannou; Coziana Ciurtin; Ines Pineda-Torra; Elizabeth C Jury | Elizabeth C Jury | University College London | 2019-06-25 | 1 | cc_no | rheumatology | https://www.medrxiv.org/content/early/2019/06/25/19000356.source.xml | BACKGROUNDJuvenile-onset systemic lupus erythematosus (JSLE) is an autoimmune disorder characterised by immune dysregulation, chronic inflammation and increased cardiovascular risk (CVR). Cardiovascular disease is the leading cause of mortality in JSLE patients not attributable to disease flares. However, it is not pos... | 10.1016/j.ebiom.2021.103243 | medrxiv | 14 | |
10.1101/19000687 | Electrocardiographic Changes After Completion of a Triathlon | Caroline Hosatte-Ducassy; Jose Correa; Francois Lalonde; Rohit Mohindra; Michael Chetrit; Gregory Marton; Audrey Marcotte; Francois Tournoux; Eileen Bridges | Caroline Hosatte-Ducassy | McGill University, Department of Emergency Medicine | 2019-06-25 | 1 | cc_by_nc_nd | sports medicine | https://www.medrxiv.org/content/early/2019/06/25/19000687.source.xml | ObjectivesGiven the increasing popularity of long-distance triathlon events amongst amateur athlete and the difficulty for emergency physician to address cardiovascular complaints in the context of exercise, this study aims to:
- Identify the prevalence of electrocardiographic abnormalities before and after a long dis... | 10.1002/tsm2.134 | medrxiv | 15 | |
10.1101/19000786 | Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review | Abdulelah Aldhahir; John Hurst; Swapna Mandal; Ahmed Alrajeh; Yousef Aldabayan; Jaber Alqahtani; Salifu Drammeh; Vanitha Subbu | Abdulelah Aldhahir | University College London | 2019-06-28 | 1 | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/06/28/19000786.source.xml | BackgroundUptake of nutritional supplementation during pulmonary rehabilitation (PR) for people with chronic obstructive pulmonary disease (COPD) has been limited by an absence of rigorous evidence-based studies supporting use. Our objective were to report and summarise the current evidence supporting use of nutritiona... | 10.1177/1479973120904953 | medrxiv | 17 | |
10.1101/19000661 | Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels | Dona M. Kanavy; Shannon M. McNulty; Meera K. Jairath; Sarah E. Brnich; Chris Bizon; Bradford C. Powell; Jonathan S. Berg | Jonathan S. Berg | University of North Carolina at Chapel Hill | 2019-06-28 | 1 | cc_by_nc_nd | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/06/28/19000661.source.xml | BackgroundThe 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines for clinical sequence variant interpretation state that "well-established" functional studies can be used as evidence in variant classification. These guidelines articulated key attribute... | 10.1186/s13073-019-0683-1 | medrxiv | 18 | |
10.1101/19000521 | Association of puberty timing with Type 2 diabetes: Systematic review and meta-analysis | Tuck Seng Cheng; Felix R. Day; Rajalakshmi Lakshman; Ken K. Ong | Tuck Seng Cheng | University of Cambridge | 2019-06-28 | 1 | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/06/28/19000521.source.xml | OBJECTIVEWe aimed to systematically review published evidence on the association between puberty timing and Type 2 diabetes or impaired glucose tolerance (T2D/IGT), with and without adjustment for adiposity, and to estimate its potential contribution to the burden of T2D.
RESEARCH DESIGN AND METHODSWe searched PubMed,... | 10.1371/journal.pmed.1003017 | medrxiv | 19 | |
10.1101/19001123 | Epigenetic prediction of major depressive disorder | Miruna C Barbu; Rosie M Walker; David M Howard; Kathryn L Evans; Heather C Whalley; David J Porteous; Stewart W Morris; Ian J Deary; Riccardo E Marioni; Toni-Kim Clarke; Andrew M McIntosh | Andrew M McIntosh | University of Edinburgh | 2019-06-28 | 1 | cc_by | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/06/28/19001123.source.xml | ObjectiveDNA methylation (DNAm) is associated with environmental risk factors for major depressive disorder (MDD) but has not yet been tested for its ability to discriminate individuals with MDD from unaffected individuals.
MethodsUsing penalized regression based on genome-wide CpG methylation, we trained a DNAm risk ... | 10.1038/s41380-020-0808-3 | medrxiv | 20 | |
10.1101/19001115 | Forecasting the impact of population ageing on tuberculosis incidence | Chu-Chang Ku; Peter J Dodd | Chu-Chang Ku | School of Health and Related Research, University of Sheffield | 2019-06-28 | 1 | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/06/28/19001115.source.xml | BackgroundTuberculosis (TB) disease reactivates from distant latent infection or recent (re)infection. Progression risks increase with age. Across the World Health Organisation Western Pacific region, many populations are ageing and have the highest per capita TB incidence rates in older age groups. However, methods fo... | 10.1371/journal.pone.0222937 | medrxiv | 21 | |
10.1101/19001008 | Current characteristics and outcomes of Cytomegalovirus Reactivation in kidney transplant seropositive recipients in the era of prophylaxis treatment. Lesson from single Moroccan center experience. | REZZOUK, B.; Bouattar, T.; Belkadi, B.; Razine, R.; Bayahia, R.; Ouzeddoun, N.; Benamar, L.; Rhou, H.; Bouihat, N.; Ibrahimi, A.; Seffar, M.; Kabbaj, H. | Bouchra REZZOUK | Laboratory of Microbiology and Molecular Biology, Faculty of Science, University Mohammed V, Rabat, Morocco. | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | infectious diseases | https://www.medrxiv.org/content/early/2019/06/28/19001008.source.xml | Despite the use of antiviral prophylaxis, the active cytomegalovirus (CMV) replication is still occurred in the seropositive kidney recipients. The aim of this study was to assess the incidence of CMV reactivation and potential risk factors associated with CMV disease. Data of sixty kidney transplant recipients who had... | 10.2147/trrm.s278655 | medrxiv | 24 |
10.1101/19000422 | The nature of clusters of multimorbid patients in the UK: a latent class analysis. | Zhu, Y.; Edwards, D.; Payne, R. A.; Kiddle, S. | Yajing Zhu | MRC Biostatistics Unit, University of Cambridge | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/06/28/19000422.source.xml | BackgroundMultimorbidity is one of the principal challenges facing health systems worldwide. To help understand the changes to services and policies that are required to deliver better care, we used a novel approach to investigate which diseases co-occur and how combinations are associated with mortality and service us... | 10.1016/S0140-6736(19)32899-5 | medrxiv | 26 |
10.1101/19000646 | Big Five Personality Traits Influence Tinnitus Improvement Over Time | Simoes, J. P.; Schlee, W.; Schecklmann, M.; Langguth, B.; Farahmand, D.; Neff, P. | Jorge Piano Simoes | University of Regensburg | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/06/28/19000646.source.xml | Previous studies investigating the relation between personality and tinnitus distress showed that high neuroticism and low extraversion scores are related to higher tinnitus distress measured by the Tinnitus Handicap Inventory (THI) and the Tinnitus Questionnaire (TQ). However, little is known about the role of persona... | 10.1038/s41598-019-53845-4 | medrxiv | 27 |
10.1101/19000190 | Cost-Sensitive Machine Learning Classification for Mass Tuberculosis Screening | Septiandri, A. A.; Aditiawarman, A.; Tjiong, R.; Burhan, E.; Shankar, A. H. | Ali Akbar Septiandri | Inovasi Sehat Indonesia | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | health informatics | https://www.medrxiv.org/content/early/2019/06/28/19000190.source.xml | Active screening for Tuberculosis (TB) is needed to optimize detection and treatment. However, current algorithms for verbal screening perform poorly, causing misclassification that leads to missed cases and unnecessary and costly laboratory tests for false positives. We investigated the role of machine learning to imp... | NA | medrxiv | 28 |
10.1101/19000554 | Integrating Online Georeferenced Epidemiological Analysis and Visualization into a Telemedicine Infrastructure - First Results | von Wangenheim, A.; Savaris, A.; Borgatto, A. F.; Inacio, A. D. S. | Aldo von Wangenheim | Federal University of Santa Catarina - UFSC | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | health informatics | https://www.medrxiv.org/content/early/2019/06/28/19000554.source.xml | With the objective to perform a first evaluation of the impact of the integration of a graphic spatial epidemiology tool that allows quasi-realtime georeferenced data visualization into a telemedicine infrastructure, this work presents GISTelemed, an online module specialized on indexing structured and semi-structured ... | NA | medrxiv | 29 |
10.1101/19000570 | Maternal Mortality and Women's Political Participation | Bhalotra, S. R.; Clarke, D.; Gomes, J.; Venkataramani, A. S. | Atheendar S Venkataramani | University of Pennsylvania | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_no | health policy | https://www.medrxiv.org/content/early/2019/06/28/19000570.source.xml | We show that large declines in maternal mortality can be achieved by raising womens political participation. We estimate that the recent wave of quotas for women in parliament in low income countries has resulted in a 9 to 12% decline in maternal mortality. Among mechanisms are that gender quotas lead to an 8 to 10% in... | NA | medrxiv | 30 |
10.1101/19000844 | An acute bleomycin inflammatory and fibrotic mouse model of morphea is dependent upon CXCL9 and CXCR3 | Richmond, J. M.; Patel, D.; Watanabe, T.; Garelli, C.; Garg, M.; Dresser, K.; Deng, A.; Feghali-Bostwick, C. A.; Harris, J. E.; Jacobe, H. T. | Heidi T Jacobe | University of Texas Southwestern Medical Center | 2019-06-28 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | dermatology | https://www.medrxiv.org/content/early/2019/06/28/19000844.source.xml | Morphea, or localized scleroderma, is characterized by an inflammatory phase followed by cutaneous fibrosis, which may lead to disfigurement and/or disability. Previous work from our group showed that the CXCR3 ligands CXCL9 and CXCL10 are highly upregulated in lesional skin of morphea patients. Here, we used an acute ... | 10.1016/j.jid.2022.11.025 | medrxiv | 31 |
10.1101/19000109 | Molecular profiling of neonatal dried blood spots reveals changes in innate and adaptive immunity following fetal inflammatory response | Costa, D.; Bonet, N.; Sole, A.; Gonzalez de Aledo-Castillo, J. M.; Sabido, E.; Casals, F.; Rovira, C.; Nadal, A.; Marin, J. L.; Cobo, T.; Castelo, R. | Robert Castelo | Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; Research Programme on Biomedical Informatics, Institut Hospita | 2019-07-09 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/07/09/19000109.source.xml | The fetal inflammatory response (FIR) increases the risk of perinatal brain injury, particularly in extremely low gestational age newborns (ELGANs, < 28 weeks of gestation). One of the mechanisms contributing to such a risk is a postnatal intermittent or sustained systemic inflammation (ISSI) following FIR. The link be... | 10.1111/febs.15578 | medrxiv | 0 |
10.1101/19000919 | Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care. | MacKenna, B.; Curtis, H. J.; Walker, A. J.; Croker, R.; Bacon, S.; Goldacre, B. | Ben Goldacre | University of Oxford | 2019-07-02 | 2 | PUBLISHAHEADOFPRINT | cc_by | health systems and quality improvement | https://www.medrxiv.org/content/early/2019/07/02/19000919.source.xml | ObjectiveTo describe trends and geographical variation in methotrexate prescribing that breaches national safety recommendations; deaths from methotrexate poisoning; and associated litigation.
MethodsA retrospective cohort study of English NHS primary care prescribing data, complemented by information obtained through... | 10.3399/bjgp20X710993 | medrxiv | 1 |
10.1101/19000497 | Proximal and distal factors predicting timely initiation of breastfeeding in Ethiopia: a systematic review and meta-analysis | Habtewold, T. D.; Mohammed, S. H.; Endalamaw, A.; Mulugeta, H.; Dessie, G.; Berhe, D. F.; Birhanu, M. M.; Islam, M. A.; Teferra, A. A.; Asefa, N. G.; Alemu, S. M. | Tesfa Dejenie Habtewold | Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands | 2019-07-08 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/07/08/19000497.source.xml | BackgroundIn Ethiopia, the current coverage of timely initiation of breast feeding (TIBF) has fallen short of the national Health Sector Transformation Plan 2016-2020, National Nutrition Program 2016-2020 and WHO global target. This calls for the need to assess relevant proximal and distal factors that affect the rate ... | 10.1111/apa.15278 | medrxiv | 2 |
10.1101/19001024 | Disease overarching mechanisms that explain and predict outcome of patients with high cardiovascular risk: rationale and design of the Berlin Long-term Observation of Vascular Events (BeLOVE) study | Siegerink, B.; Weber, J.; Ahmadi, M.; Eckardt, K.-U.; Edelmann, F.; Endres, M.; Gerhardt, H.; Haubold, K.; Hübner, N.; Landmesser, U.; Leistner, D.; Mai, K.; Müller, D. N.; Pieske, B.; Rauch, G.; Schmidt, S.; Schmidt-Ott, K. M.; Schulz-Menger, J.; Spranger, J.; Pischon, T. | Tobias Pischon | Berlin Institute of Health (BIH) & German Center for Cardiovascular Research (DZHK) & Charité Universitätsmedizin & Max-Delbrück Center for Molecular Medicine i | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/07/15/19001024.source.xml | BackgroundCardiovascular disease (CVD) is the leading cause of premature death worldwide. Effective and individualized treatment requires exact knowledge about both risk factors and risk estimation. Most evidence for risk prediction currently comes from population-based studies on first incident cardiovascular events. ... | NA | medrxiv | 4 |
10.1101/19000232 | Optimising the use of molecular tools for the diagnosis of yaws | Munson, M.; Cresswell, B.; Kondobala, K.; Gainwu, B.; Lomotey, R. D.; Oppong, P.; Agyeman, F. O.; Kotye, N.; Diwura, M.; Ako, E. P.; Simpson, S. V.; Addo, K. K.; Pickering, H.; Handley, R.; Houghton, J.; Kwakye, C.; Marks, M. | Michael Marks | London School of Hygiene and Tropical Medicine | 2019-07-15 | 3 | PUBLISHAHEADOFPRINT | cc_by | infectious diseases | https://www.medrxiv.org/content/early/2019/07/15/19000232.source.xml | IntroductionYaws is a neglected tropical disease and results in lesions of skin, soft tissues and bones. PCR plays an important part in surveillance.
MethodsChildren suspected to have yaws were enrolled. From the largest lesion paired swabs were collected; one into transport medium and one as a dry swab. In children w... | 10.1093/trstmh/trz083 | medrxiv | 6 |
10.1101/19000851 | SEXUAL BEHAVIOURS AND EXPERIENCE OF SEXUAL COERCION AMONG IN-SCHOOL FEMALE ADOLESCENT IN SOUTHWESTERN NIGERIA | Owolodun, B. S.; Sanusi, R. A. | Babatunde Samuel Owolodun | University of Ibadan | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | public and global health | https://www.medrxiv.org/content/early/2019/07/03/19000851.source.xml | Most people begin their sexual relationship during adolescence and some get involved in risky life threatening behaviors such as unwanted pregnancies, abortions and sexually transmitted infections. This study was therefore designed to understand the patterns of female adolescents sexual behaviours and sexual coercion e... | NA | medrxiv | 7 |
10.1101/19000711 | Robotic middle ear access for cochlear implantation: first in man | Caversaccio, M.; Wimmer, W.; Anso, J.; Mantokoudis, G.; Gerber, N.; Rathgeb, C.; Schneider, D.; Hermann, J.; Wagner, F.; Scheidegger, O.; Huth, M.; Anschuetz, L.; Kompis, M.; Williamson, T.; Bell, B.; Gavaghan, K.; Weber, S. | Wilhelm Wimmer | Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | otolaryngology | https://www.medrxiv.org/content/early/2019/07/03/19000711.source.xml | To demonstrate the feasibility of robotic middle ear access in a clinical setting, nine adult patients with severe-to-profound hearing loss indicated for cochlear implantation were included in this clinical trial. A keyhole access tunnel to the tympanic cavity and targeting the round window was planned based on preoper... | 10.1371/journal.pone.0220543 | medrxiv | 8 |
10.1101/19000414 | The effectiveness of digital technology interventions to reduce loneliness in adult people: A protocol for a systematic review and meta-analysis | Shah, S. G. S.; Nogueras, D.; van Woerden, H. C.; Kiparoglou, V. | Syed Ghulam Sarwar Shah | NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | public and global health | https://www.medrxiv.org/content/early/2019/07/03/19000414.source.xml | IntroductionLoneliness is an emerging public health problem, which is associated with social, emotional, mental and physical health issues. The application of digital technology (DT) interventions to reduce loneliness has increased in recent years. The effectiveness of DT interventions needs to be assessed systematical... | 10.1136/bmjopen-2019-032455 | medrxiv | 10 |
10.1101/19000927 | Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing | Lohoefer, F. K.; Kaissis, G. A.; Mueller-Leisse, C.; Franz, D.; Katemann, C.; Hock, A.; Peeters, J. M.; Rummeny, E. J.; Karampinos, D.; Braren, R. | Rickmer Braren | TU Muenchen, Institute for diagnostic and interventional Radiology | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | radiology and imaging | https://www.medrxiv.org/content/early/2019/07/03/19000927.source.xml | ObjectivesTo evaluate proton density fat fraction (PDFF) and T2* measurements of the liver with combined parallel imaging (sensitivity encoding, SENSE) and compressed sensing (CS) accelerated chemical shift encoding-based water-fat separation.
MethodsSix-echo Dixon imaging was performed in the liver of 89 subjects. Th... | 10.1371/journal.pone.0224988 | medrxiv | 12 |
10.1101/19001149 | Aerobic capacity predicts skeletal but not cardiac muscle damage after a full distance Ironman triathlon - the Iron(wo)man-study | Danielsson, T.; Carlsson, J.; Ten Siethoff, L.; Ahnesjo, J.; Bergman, P. | Patrick Bergman | Linnaeus University | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | sports medicine | https://www.medrxiv.org/content/early/2019/07/03/19001149.source.xml | PurposeThis study examines the association between aerobic capacity and biomarkers of skeletal- and cardiac muscle damage among amateur triathletes after a full distance Ironman.
MethodsMen and women (N=55) were recruited from local sport clubs. One month before an Iron-man triathlon, they conducted a 20m shuttle run ... | 10.1038/s41598-020-57842-w | medrxiv | 13 |
10.1101/19001073 | Machine learning to predict early recurrence after oesophageal cancer surgery | Rahman, S.; Walker, R. C.; LLoyd, M. A.; Grace, B. L.; van Boxel, G. I.; Kingma, F. B.; Ruurda, J. P.; van Hillegersberg, R.; Harris, S.; Parsons, S.; Mercer, S.; Griffiths, E. A.; O'Neill, J. R.; Turkington, R.; Fitzgerald, R.; Underwood, T. J.; OCCAMS Consortium, | Timothy J Underwood | Cancer Sciences Unit, University of Southampton, Southampton, UK | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | surgery | https://www.medrxiv.org/content/early/2019/07/03/19001073.source.xml | ObjectiveTo develop a predictive model for early recurrence after surgery for oesophageal adenocarcinoma using a large multi-national cohort.
Summary Background DataEarly cancer recurrence after oesophagectomy is a common problem with an incidence of 20-30% despite the widespread use of neoadjuvant treatment. Quantifi... | 10.1002/bjs.11461 | medrxiv | 14 |
10.1101/19001222 | Predicting Residual Function in Hemodialysis and Hemodiafiltration : A Population Kinetic, Decision Analytic Approach | Achakzai, M.; Argyropoulos, C.; Roumelioti, M. - E. | Christos Argyropoulos | Department of Internal Medicine, Division of Nephrology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA | 2019-07-09 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nephrology | https://www.medrxiv.org/content/early/2019/07/09/19001222.source.xml | In this study, we introduce a novel framework for the estimation of residual renal function (RRF), based on the population compartmental kinetic behavior of Beta 2 Microglobulin (B2M) and its dialytic removal. Using this model, we simulated a large cohort of patients with various levels of RRF receiving either conventi... | 10.3390/jcm8122080 | medrxiv | 16 |
10.1101/19001362 | The impact of involving young children in improving the understanding of a new eye test | Casanova, T.; Black, C.; Rafiq, S.; Hugill, J.; Read, J. C. A.; Vancleef, K. | Kathleen Vancleef | Newcastle University, University of Oxford | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | ophthalmology | https://www.medrxiv.org/content/early/2019/07/03/19001362.source.xml | BackgroundAlthough considered important, the involvement of young children in research is rare and its impact has never been measured. We aim to provide a good practice example of involvement of young children in the development of a tablet-based 3D eye test or stereotest, ASTEROID. We focus on improving understanding ... | 10.1186/s40900-020-00194-6 | medrxiv | 17 |
10.1101/19000877 | A Needs Analysis of Parents Following Sudden Cardiac Death in the Young | McDonald, K.; Sharpe, L.; Yeates, L.; Semsarian, C.; Ingles, J. | Jodie Ingles | Centenary Institute, The University of Sydney | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | cardiovascular medicine | https://www.medrxiv.org/content/early/2019/07/03/19000877.source.xml | The sudden cardiac death (SCD) of a young person is a devastating event for any parent. Inherited heart disease is often either identified or assumed to be the cause. Few studies have explored the psychosocial impact to the surviving at-risk family members. We sought to investigate the needs of parents who have experie... | 10.1136/openhrt-2019-001120 | medrxiv | 18 |
10.1101/19001321 | Accuracy of ECG Chest Electrode Placements by Paramedics; an observational study | Gregory, P.; Lodge, S.; Kilner, T.; Paget, S. | Pete Gregory | University of Wolverhampton | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | emergency medicine | https://www.medrxiv.org/content/early/2019/07/03/19001321.source.xml | BackgroundThe use of the 12-lead ECG is common in UK paramedic practice but its value depends upon accurate placement of the ECG-electrodes. Several studies have shown widespread variation in the placement of chest electrodes by other health professionals but no studies have addressed the accuracy of paramedics. The ma... | 10.29045/14784726.2019.12.4.3.51 | medrxiv | 19 |
10.1101/19000539 | Health workers experiences of coping with the Ebola epidemic in the Democratic Republic of the Congo health system: a qualitative study of variables of hospital activities on infection control practices in Kinshasa city | Tshima, G. K.; Kalala, K. T. | Guyguy Kabundi Tshima | Universite de Kinshasa | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/03/19000539.source.xml | Health workers play an important role during epidemics, but there is limited research on hospital activities on infection control practices in the Democratic Republic of the Congo and how health workers can cope during a probable health epidemic in Kinshasa city. The determinants of the current Ebola Virus Disease in t... | NA | medrxiv | 20 |
10.1101/19000539 | Show solidarity with the Congolese people in the 10th Ebola outbreak declared a health emergency of international concern: understand a qualitative study of variables of hospital activities on infection control practices in Kinshasa city | Tshima, G. K.; Kalala, K. T. | Guyguy Kabundi Tshima | Universite de Kinshasa | 2019-07-23 | 2 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/23/19000539.source.xml | Health workers play an important role during epidemics, but there is limited research on hospital activities on infection control practices in the Democratic Republic of the Congo and how health workers can cope during a probable health epidemic in Kinshasa city. The determinants of the current Ebola Virus Disease in t... | NA | medrxiv | 21 |
10.1101/19000968 | Liver function tests and fibrosis scores in a rural population in Africa: estimation of the burden of disease and associated risk factors | O'Hara, G.; Mokaya, J.; Hau, J. P.; Downs, L. O.; McNaughton, A. L.; Karabarinde, A.; Asiki, G.; Seeley, J.; Matthews, P. C.; Newton, R. | Philippa C Matthews | Nuffield Department of Medicine, University of Oxford, Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_by | gastroenterology | https://www.medrxiv.org/content/early/2019/07/03/19000968.source.xml | IntroductionLiver disease is a major cause of morbidity and mortality in sub-Saharan Africa. However, its prevalence, distribution and aetiology have not been well characterised. We examined liver function tests (LFTs) and calculated liver fibrosis scores in a rural population in Uganda.
MethodologyA cross-sectional s... | 10.1136/bmjopen-2019-032890 | medrxiv | 22 |
10.1101/19001255 | A CALCIUM-RICH MULTI-MINERAL INTERVENTION TO MODULATE COLONIC MICROBIAL COMMUNITIES AND METABOLOMIC PROFILES IN HUMANS:Results from a 90-day trial | Aslam, M. N.; Bassis, C. M.; Bergin, I. L.; Knuver, K.; Zick, S.; Sen, A.; Turgeon, D. K.; Varani, J. | Muhammad N Aslam | University of Michigan Medical School | 2019-07-03 | 1 | PUBLISHAHEADOFPRINT | cc_no | gastroenterology | https://www.medrxiv.org/content/early/2019/07/03/19001255.source.xml | Aquamin, a calcium-, magnesium-, and multiple trace element-rich natural product has polyp prevention efficacy based on preclinical studies. The overall goal of this study was to determine the safety and tolerability of Aquamin when used as a dietary chemopreventative in humans. Additionally, we determined the effects ... | 10.1158/1940-6207.CAPR-19-0325 | medrxiv | 23 |
10.1101/19000489 | Misclassification of a whole genome sequence reference defined by the Human Microbiome Project: a detrimental carryover effect to microbiome studies | Bandoy, D. D. R.; Huang, B. C.; Weimer, B. C. | Bart C Weimer | UC Davis | 2019-07-06 | 1 | PUBLISHAHEADOFPRINT | cc_no | infectious diseases | https://www.medrxiv.org/content/early/2019/07/06/19000489.source.xml | Taxonomic classification is an essential step in the analysis of microbiome data that depends on a reference database of whole genome sequences. Taxonomic classifiers are built on established reference species, such as the Human Microbiome Project database, that is growing rapidly. While constructing a population wide ... | NA | medrxiv | 24 |
10.1101/19001230 | The effect of the genetic liability to autism spectrum disorder on emotion recognition in young unaffected probands from a population-based cohort | Wendt, F. R.; Muniz Carvalho, C.; Gelernter, J.; Polimanti, R. | Renato Polimanti | Yale School of Medicine | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_no | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/07/08/19001230.source.xml | We investigated how ASD genetic risk relates to neurodevelopmental features (491 traits tested) via polygenic risk scoring (PRS) in 4,309 young non-ASD probands from the Philadelphia Neurodevelopmental Cohort. ASD PRS most strongly associated with the ability to correctly identify angry facial emotions in youths aged 1... | 10.1016/j.euroneuro.2019.08.213 | medrxiv | 26 |
10.1101/19001156 | Intermittent Lactobacilli-containing Vaginal Probiotic or Metronidazole Use to Prevent Bacterial Vaginosis Recurrence: Safety and Preliminary Efficacy by Microscopy and Sequencing | van de Wijgert, J.; Verwijs, M. C.; Agaba, S. K.; Bronowski, C.; Mwambarangwe, L.; Uwineza, M.; Lievens, E.; Nivoliez, A.; Ravel, J.; Darby, A. | Janneke van de Wijgert | Institute of Infection and Global Health, University of Liverpool, Liverpool, UK | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | sexual and reproductive health | https://www.medrxiv.org/content/early/2019/07/08/19001156.source.xml | Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n=17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), or ... | 10.1038/s41598-020-60671-6 | medrxiv | 27 |
10.1101/19001511 | Cluster analysis successfully identifies clinically meaningful knee valgus moment patterns: Frequency of early peaks reflects sex-specific ACL injury incidence | Sigurthsson, H. B.; Briem, K. | Haraldur Björn Sigurðsson | University of Iceland | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | sports medicine | https://www.medrxiv.org/content/early/2019/07/08/19001511.source.xml | BackgroundBiomechanical studies of ACL injury risk factors report heterogenous results, analyze only a fraction of the data, and do not analyze data in accordance with the injury mechanism. Extracting a peak value of relevance to ACL injuries is challenging due to differences in the relative timing of the peak value.
... | 10.1186/s40634-019-0205-5 | medrxiv | 28 |
10.1101/19001537 | Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and senile systemic amyloidoses | De Lillo, A.; De Angelis, F.; Di Girolamo, M.; Luigetti, M.; Frusconi, S.; Manfellotto, D.; Fuciarelli, M.; Polimanti, R. | Renato Polimanti | Yale University | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/07/08/19001537.source.xml | Transthyretin (TTR) gene has a causal role in a hereditary form of amyloidosis (ATTRm) and is potentially involved in the risk of senile systemic amyloidosis (SSA). To understand the genetics of ATTRm and SSA, we conducted a phenome-wide association study of TTR gene in 361,194 participants of European descent testing ... | 10.1007/s00439-019-02078-6 | medrxiv | 29 |
10.1101/19001545 | Bayesian spatial modelling of childhood cancer incidence in Switzerland using exact point data: A nationwide study during 1985-2015. | Konstantinoudis, G.; Schuhmacher, D.; Ammann, R.; Diesch, T.; Kuehni, C.; Spycher, B. D. | Ben Daniel Spycher | Institute of social and preventive medicine, University of Bern | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_by | epidemiology | https://www.medrxiv.org/content/early/2019/07/15/19001545.source.xml | BackgroundThe aetiology of most childhood cancers is largely unknown. Spatially varying environmental factors such as traffic-related air pollution, background radiation and agricultural pesticides might contribute to the development of childhood cancer. We investigated the spatial variation of childhood cancers in Swi... | 10.1186/s12942-020-00211-7 | medrxiv | 32 |
10.1101/19001578 | Public knowledge and attitude towards epilepsy and its associated factors in Debre Berhan, North Shoa, Amhara Region, Ethiopia, 2018/19. Community based cross sectional study | dargie, a. w.; engidaw, n. a.; basha, e. a. | abate wubetu dargie Jr. | Debre Berhan University | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/07/15/19001578.source.xml | IntroductionEpilepsy is chronic brain disorder characterized by recurrent derangement of the nervous system due to the sudden excessive disorderly discharge of the cerebral neurons. People living with epilepsy continue to suffer from enacted or perceived stigma that is based on myths, misconceptions, and misunderstandi... | NA | medrxiv | 34 |
10.1101/19001719 | Antihypertensive medications as repurposed treatments for mood disorders: analysis of linked healthcare data for 1.8 million patients | Shaw, R. J.; Mackay, D.; Pell, J. P.; Padmanabhan, S.; Bailey, D. S.; Smith, D. J. | Richard John Shaw | University of Glasgow | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_no | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/07/08/19001719.source.xml | BackgroundRecent work suggests that antihypertensive medications may be useful as repurposed treatments for mood disorders. Using large-scale linked healthcare data we investigated whether certain classes of antihypertensive, such as angiotensin antagonists and calcium channel blockers, were associated with reduced ris... | 10.1017/S0033291719004094 | medrxiv | 35 |
10.1101/19001610 | Impact of a regional educational advertising campaign on harm perceptions of e-cigarettes, prevalence of e-cigarette use, and quit attempts among smokers | Tattan-Birch, H.; Jackson, S. E.; Ide, C.; Bauld, L.; Shahab, L. | Harry Tattan-Birch | University College London, UK | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc | public and global health | https://www.medrxiv.org/content/early/2019/07/08/19001610.source.xml | BackgroundWe evaluated how effective an advertising campaign that was piloted by Cancer Research UK in January/February 2018 was at promoting quit attempts by increasing awareness of the relative harms of e-cigarettes compared with smoking.
MethodsAdults ([≥]16 years, n = 2217) living in Greater Manchester (campaig... | 10.1093/ntr/ntz236 | medrxiv | 36 |
10.1101/19001594 | Plasma Itaconate elevation following successful cDMARD treatment in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation | Daly, R.; Blackburn, G.; Mudaliar, M.; Burgess, K.; Stirling, A.; Porter, D.; McInnes, I.; Barrett, M. P.; Dale, J. | James Dale | University of Glasgow | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_no | rheumatology | https://www.medrxiv.org/content/early/2019/07/08/19001594.source.xml | ObjectiveTo characterize changes in the plasma metabolic profile in newly diagnosed rheumatoid arthritis (RA) patients upon commencement of conventional disease modifying anti-rheumatic drug (cDMARD) therapy.
MethodsPlasma samples collected in an early RA randomized strategy study (NCT00920478) that compared clinical ... | 10.3390/metabo10060241 | medrxiv | 37 |
10.1101/19000760 | Reduced survival in COPD patients who received long-term oxygen therapy without meeting prescription criteria: a preliminary study | Alexandre, F.; Varray, A.; Stephan, Y.; Hayot, M.; Heraud, N. | Francois Alexandre | Les Cliniques du Souffle, groupe 5-Sante | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | respiratory medicine | https://www.medrxiv.org/content/early/2019/07/08/19000760.source.xml | BackgroundRandomized clinical trials have provided clear evidence that long-term oxygen therapy (LTOT) increases life expectancy in severely hypoxemic COPD patients. However, in real-life settings, in global COPD cohorts, a paradoxical 2-3-fold increased risk of death has been reported in patients under LTOT. This disc... | NA | medrxiv | 38 |
10.1101/19000950 | Oncofetal Protein Cripto-1 in a new clinical role: a potential tumor marker for Oral Squamous Cell Carcinoma. | Jain, A.; Mallupattu, S. K.; Thakur, R.; Mohindra, S.; Bal, A.; Das, A.; Ghoshal, S.; Pal, A. | Arnab Pal | Department of Biochemistry, Post Graduate Institute of Medical Education and Research | 2019-07-08 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc | oncology | https://www.medrxiv.org/content/early/2019/07/08/19000950.source.xml | PURPOSECR-1 (CR-1) is an oncofetal protein with its role as a key factor in early process of carcinoma has been evaluated in cases of various cancers. However, very few studies have reported its role in oral cancers, which is the sixth most common cancer around the world, particularly with high prevalence in developing... | 10.1007/s12291-020-00898-2 | medrxiv | 39 |
10.1101/19001248 | Higher energy requirement during weight-loss maintenance on a low- versus high-carbohydrate diet: secondary analyses from a randomized controlled feeding study | Ebbeling, C. B.; Bielak, L.; Lakin, P. R.; Klein, G. L.; Wong, J. M.; Luoto, P. K.; Wong, W. W.; Ludwig, D. S. | David S Ludwig | Boston Children\'s Hospital, Harvard Med School | 2019-07-11 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/07/11/19001248.source.xml | BackgroundLonger-term feeding studies suggest that a low-carbohydrate diet increases energy expenditure, consistent with the carbohydrate-insulin model of obesity. However, the validity of methodology utilized in these studies, involving doubly-labeled water, has been questioned.
ObjectiveThe aim of this study was to ... | 10.1093/jn/nxaa150 | medrxiv | 40 |
10.1101/19001206 | Detection of malaria parasites in dried human blood spots using mid-infrared spectroscopy and logistic regression analysis | Mwanga, E. P.; Minja, E. G.; Mrimi, E.; Gonzalez Jimenez, M.; Swai, J. K.; Abbas, S.; Ngowo, H. S.; Siria, D. J.; Mapua, S. A.; Stica, C.; Maia, M. F.; Olotu, A.; Sikulu-Lord, M. T.; Baldini, F.; Ferguson, H. M.; Wynne, K.; Selvaraj, P.; Babayan, S. A.; Okumu, F. O. | Fredros O Okumu | Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Morogoro, Tanzania; Institute of Biodiversity, Animal Health and Comparative | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | infectious diseases | https://www.medrxiv.org/content/early/2019/07/12/19001206.source.xml | BackgroundEpidemiological surveys of malaria currently rely on microscopy, polymerase chain reaction assays (PCR) or rapid diagnostic test kits for Plasmodium infections (RDTs). This study shows that mid-infrared (MIR) spectroscopy coupled with supervised machine learning could constitute an alternative method for rapi... | 10.1186/s12936-019-2982-9 | medrxiv | 41 |
10.1101/19001396 | Post-Exposure Effects of Vaccines on Infectious Diseases | Gallagher, T. E.; Lipsitch, M. | Tara E Gallagher | Dartmouth College | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | infectious diseases | https://www.medrxiv.org/content/early/2019/07/12/19001396.source.xml | Many available vaccines have demonstrated post-exposure effectiveness, but no published systematic reviews have synthesized these findings. We searched the PubMed database for clinical trials and observational human studies concerning the post-exposure vaccination effects, targeting infections with an FDA-licensed vacc... | 10.1093/epirev/mxz014 | medrxiv | 42 |
10.1101/19002014 | Epigenetic field cancerization in breast cancer using subject-matched tumor, ipsilateral-normal, and contralateral-normal tissues | Muse, M. E.; Titus, A. J.; Salas, L. A.; Wilkins, O. M.; Mullen, C.; Gregory, K. J.; Schneider, S. S.; Crisi, G. M.; Jarwale, R. M.; Otis, C. N.; Christensen, B. C.; Arcaro, K. F. | Kathleen F. Arcaro | University of Massachusetts, Amherst, MA | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | epidemiology | https://www.medrxiv.org/content/early/2019/07/12/19002014.source.xml | BackgroundEmerging work has demonstrated that histologically normal (non-tumor) tissue adjacent to breast tumor tissue shows evidence of molecular alterations related to tumorigenesis, referred to as field cancerization effects. Although changes in DNA methylation are known to occur early in breast carcinogenesis and t... | NA | medrxiv | 43 |
10.1101/19001404 | The fecal microbiome in diverticulitis and asymptomatic diverticulosis: A case-control study in the US | Hullar, M. A.; Sandstrom, R. S.; Stamatoyannopoulos, J. A.; Lampe, J. W.; Strate, L. L. | Lisa L Strate | University of Washington School of Medicine | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_no | gastroenterology | https://www.medrxiv.org/content/early/2019/07/12/19001404.source.xml | ObjectiveThe intestinal microbiota are hypothesized to play a role in the pathogenesis of diverticulitis. We compared fecal microbial communities in individuals with diverticulitis to those with uncomplicated diverticulosis.
MethodsWe used 16S ribosomal RNA gene sequencing to assess and compare the microbiota composit... | NA | medrxiv | 44 |
10.1101/19001495 | Why so many significant Phase 3 results in clinical trials? | Adda, J.; Decker, C.; Ottaviani, M. | Marco Ottaviani | Bocconi University | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_no | health economics | https://www.medrxiv.org/content/early/2019/07/12/19001495.source.xml | Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold unfavorable results or even tamper with data in order to achieve desired outcome... | 10.1073/pnas.1919906117 | medrxiv | 45 |
10.1101/19001487 | Cardiac arrest outcomes after targeted temperature management with an esophageal cooling device | Wayne, M. A.; Anderson, C.; Fisher, R.; Berry, D.; Diestelhorst, J. B. | Marvin A Wayne | PeaceHealth St. Joseph Medical Center | 2019-07-15 | 2 | PUBLISHAHEADOFPRINT | cc_no | intensive care and critical care medicine | https://www.medrxiv.org/content/early/2019/07/15/19001487.source.xml | ObjectiveTo assess the efficacy of an esophageal device to provide TTM (Target Temperature Management) post Cardiac Arrest
DesignA chart review of all patients treated with ETTM, following cardiac arrest. Initial patient temperature, time to target, supplemental methods (water blankets, head wraps, or ice packs), and ... | NA | medrxiv | 47 |
10.1101/19001529 | Stem Cell Transplantation Patients and Situational Meaning: A Prospective and Longitudinal View | Blosser, J.; Sabo, R.; Candler, K.; Mullin, K.; Toor, A.; Chaber, D. | Jennifer Blosser | VCU Health | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | transplantation | https://www.medrxiv.org/content/early/2019/07/12/19001529.source.xml | BackgroundThough there is thorough examination of psychosocial issues in SCT, there are few longitudinal studies examining the meaning SCT patients attribute to their treatment.
ObjectiveThe object of this study was to examine change in situational appraisal over time, and to explore potential modifiers of that change... | NA | medrxiv | 48 |
10.1101/19001925 | Prediagnostic breast milk DNA methylation alterations in women who develop breast cancer | Salas, L. A.; Lundgren, S. N.; Browne, E. P.; Punska, E. C.; Anderton, D. L.; Karagas, M. R.; Arcaro, K. F.; Christensen, B. C. | Brock C. Christensen | Geisel School of Medicine at Dartmouth | 2019-07-12 | 1 | PUBLISHAHEADOFPRINT | cc_no | genetic and genomic medicine | https://www.medrxiv.org/content/early/2019/07/12/19001925.source.xml | BackgroundPrior candidate gene studies have shown tumor suppressor DNA methylation in breast milk related with history of breast biopsy, an established risk factor for breast cancer. To further establish the utility of breast milk as a tissue-specific biospecimen for investigations of breast carcinogenesis we measured ... | 10.1093/hmg/ddz301 | medrxiv | 49 |
10.1101/19002022 | The Genetic Links to Anxiety and Depression (GLAD) Study: online recruitment into the largest recontactable study of depression and anxiety | Davies, M. R.; Kalsi, G.; Brailean, A.; Cleare, A. J.; Coleman, J. R.; Curtis, C. J.; Curzons, S. C.; Davis, K. A. S.; Goldsmith, K. A.; Hammond Bennett, M.; Hotopf, M.; Hübel, C.; Leng, J.; Mason, B. D.; McAtarsney-Kovacs, M.; Monssen, D.; Palaiologou, E.; Pariante, C.; Parikh, S.; Peel, A. J.; Rimes, K.; Rogers, H.;... | Gerome Breen | Institute of Psychiatry, Psychology and Neuroscience, King\'s College London | 2019-07-22 | 2 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/07/22/19002022.source.xml | BackgroundAnxiety and depression are common, debilitating and costly. These disorders are influenced by multiple risk factors, from genes to psychological vulnerabilities and environmental stressors but research is hampered by a lack of sufficiently large comprehensive studies. We are recruiting 40,000 individuals with... | 10.1016/j.brat.2019.103503 | medrxiv | 51 |
10.1101/19002089 | Deficient goal-directed control in a population characterized by extreme goal pursuit | Foerde, K.; Daw, N.; Rufin, T.; Walsh, B. T.; Shohamy, D.; Steinglass, J. | Karin Foerde | NYSPI | 2019-07-14 | 1 | PUBLISHAHEADOFPRINT | cc_by_nd | psychiatry and clinical psychology | https://www.medrxiv.org/content/early/2019/07/14/19002089.source.xml | AO_SCPLOWBSTRACTC_SCPLOWComputational neuroscience has contributed to understanding compulsive behavior by distinguishing habitual from goal-directed choice through model-free and model-based learning. Yet, questions remain about applying this approach to psychiatric conditions that are characterized by complex behavio... | 10.1162/jocn_a_01655 | medrxiv | 52 |
10.1101/19001792 | Design of a computer model for the identification of adolescent swimmers with low BMD | Marin-Puyalto, J.; Gomez-Cabello, A.; Gomez-Bruton, A.; Matute-Llorente, A.; Gonzalez-Aguero, A.; Casajus, J. A.; Vicente-Rodriguez, G. | German Vicente-Rodriguez | Universidad de Zaragoza | 2019-07-13 | 1 | PUBLISHAHEADOFPRINT | cc_no | sports medicine | https://www.medrxiv.org/content/early/2019/07/13/19001792.source.xml | ObjectivesThis paper aims to elaborate a decision tree for the early detection of adolescent swimmers at risk of presenting low bone mineral density (BMD), based on easily measurable fitness and performance variables.
MethodsBone mineral status of 78 adolescent swimmers was determined using DXA scans at the hip and su... | NA | medrxiv | 53 |
10.1101/19001859 | Quantification of Conflicts of Interest in an Online Point-of-Care Clinical Support Website | Chopra, A. C.; Tilberry, S.; Sternat, K. E.; Chung, D. Y.; Nichols, S. D.; Piper, B. J. | Brian J Piper | Geisinger Commonwealth School of Medicine | 2019-07-14 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | medical ethics | https://www.medrxiv.org/content/early/2019/07/14/19001859.source.xml | Online medical reference websites are utilized by health care providers to enhance their education and decision making. However, these resources may not adequately reveal pharmaceutical-author interactions and their potential conflicts of interest (CoIs). This investigation: 1) evaluates the correspondence of two well-... | 10.1007/s11948-019-00153-9 | medrxiv | 54 |
10.1101/19001867 | Actigraphic Screening for Rapid Eye Movement Sleep Behavior Disorder | Sandala, K.; Dostalova, S.; Nepozitek, J.; Ibarburu, V.; Dusek, P.; Ruzicka, E.; Sonka, K.; Kemlink, D. | David Kemlink | First Faculty of Medicine, Charles University in Prague | 2019-07-14 | 1 | PUBLISHAHEADOFPRINT | cc_no | neurology | https://www.medrxiv.org/content/early/2019/07/14/19001867.source.xml | BackgroundThe patients suffering of the rapid eye movement sleep behavior disorder (RBD) are in high risk of developing a neurodegenerative disorder, most frequently from the group of alpha-synucleinopathies, such as Parkinsons disease (PD), Dementia with Lewy Bodies (DLB) or multiple system atrophy (MSA). The definiti... | NA | medrxiv | 55 |
10.1101/19001842 | Effects of vitamin D supplementation and seasonality on circulating cytokines in adolescents: analysis of data from a feasibility trial in Mongolia. | Yegorov, S.; Bromage, S.; Boldbaatar, N.; Ganmaa, D. | Sergey Yegorov | Suleyman Demirel University | 2019-07-14 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | nutrition | https://www.medrxiv.org/content/early/2019/07/14/19001842.source.xml | Vitamin D deficiency is prevalent in human populations and has been linked to immune dysfunction. Here we explored the effects of cholecalciferol supplementation on circulating cytokines in severely vitamin D deficient (blood 25(OH)D3 << 30 nmol/L) adolescents aged 12-15 from Mongolia. The study included 28 children re... | 10.3389/fnut.2019.00166 | medrxiv | 57 |
10.1101/19001917 | Reproducibility and transparency characteristics of oncology research evidence | Walters, C. G.; Harter, Z. J.; Wayant, C.; Vo, N.; Warren, M.; Chronister, J.; Tritz, D.; Vassar, M. | Corbin G Walters | Oklahoma State University Center for Health Sciences | 2019-07-14 | 1 | PUBLISHAHEADOFPRINT | cc_by | oncology | https://www.medrxiv.org/content/early/2019/07/14/19001917.source.xml | IntroductionAs much as 50%-90% of research is estimated to be irreproducible, costing upwards of $28 billion in the United States alone. Reproducible research practices are essential to improving the reproducibility and transparency of biomedical research, such as including pre-registering studies, publishing a protoco... | 10.1136/bmjopen-2019-033962 | medrxiv | 58 |
10.1101/19001958 | Redefining typhoid diagnosis: what would an improved test need to look like? | Mather, R.; Hopkins, H.; Parry, C.; Dittrich, S. | Richard Mather | London School of Hygiene and Tropical Medicine | 2019-07-14 | 1 | PUBLISHAHEADOFPRINT | cc_by | infectious diseases | https://www.medrxiv.org/content/early/2019/07/14/19001958.source.xml | IntroductionTyphoid fever is one of the most common bacterial causes of acute febrile illness in the developing world, with an estimated 10.9 million new cases and 116.8 thousand deaths in 2017. Typhoid point-of-care (POC) diagnostic tests are widely used but have poor sensitivity and specificity, resulting in antibiot... | 10.1136/bmjgh-2019-001831 | medrxiv | 59 |
10.1101/19002154 | Expert-validated estimation of diagnostic uncertainty for deep neural networks in diabetic retinopathy detection | Ayhan, M. S.; Kuehlewein, L.; Aliyeva, G.; Inhoffen, W.; Ziemssen, F.; Berens, P. | Philipp Berens | University of Tuebingen | 2019-07-15 | 1 | PUBLISHAHEADOFPRINT | cc_by_nc_nd | ophthalmology | https://www.medrxiv.org/content/early/2019/07/15/19002154.source.xml | Deep learning-based systems can achieve a diagnostic performance comparable to physicians in a variety of medical use cases including the diagnosis of diabetic retinopathy. To be useful in clinical practise, it is necessary to have well calibrated measures of the uncertainty with which these systems report their decisi... | 10.1016/j.media.2020.101724 | medrxiv | 64 |
10.1101/19002238 | An Assessment of Transparency and Reproducibility-related Research Practices in Otolaryngology | Johnson, A. L.; Torgerson, T.; Skinner, M.; Hamilton, T.; Tritz, D.; Vassar, M. | Austin L Johnson | Oklahoma State University Center for Health Science | 2019-07-15 | 1 | PUBLISHAHEADOFPRINT | cc_by | otolaryngology | https://www.medrxiv.org/content/early/2019/07/15/19002238.source.xml | IntroductionClinical research serves as the foundation for evidence-based patient care, and reproducibility of results is consequently critical. We sought to assess the transparency and reproducibility of research studies in otolaryngology by evaluating a random sample of publications in otolaryngology journals between... | 10.1002/lary.28322 | medrxiv | 65 |
10.1101/19001784 | Pain in clients attending a South African voluntary counselling and testing centre was frequent and extensive but did not depend on HIV status. | Wadley, A. L.; Lazarus, E.; Gray, G. E.; Mitchell, D.; Kamerman, P. R. | Peter R Kamerman | University of the Witwatersrand | 2019-07-15 | 1 | PUBLISHAHEADOFPRINT | cc_by | hiv aids | https://www.medrxiv.org/content/early/2019/07/15/19001784.source.xml | BackgroundThe frequency of pain is reported to be high in people living with HIV (PLWH), but valid comparisons between PLWH and HIV-negative cohorts are rare. We investigated whether HIV infection influenced frequency and characteristics of pain in adults undergoing voluntary testing for HIV.
MethodsParticipants were ... | 10.1097/qai.0000000000002248 | medrxiv | 66 |
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medRxiv Paper Metadata Dataset
This dataset includes metadata of all papers from medRxiv between June 25, 2019, and March 17, 2025.
Number of rows: 69,296 papers.
To access the full text, please visit the official website by searching the paper title or DOI: https://www.medrxiv.org/ , or retrieve the paper using the official API: https://api.medrxiv.org/ .
Dataset Fields
- doi: Digital Object Identifier.
- title: Paper title.
- authors: List of authors.
- author_corresponding: Corresponding author.
- author_corresponding_institution: Corresponding author's institution.
- date: Publication date.
- version: Version information.
- type: Paper type.
- license: License information.
- category: Subject category.
- jatsxml: Content in JATS XML format.
- abstract: Abstract.
- published: Publication status.
- server: Server information.
- index_level_0: Index.
Usage
You can load the dataset using the following code:
import pandas as pd
# Log in using huggingface-cli to access this dataset
df = pd.read_parquet("hf://datasets/jackkuo/medRxiv_meta/combined_medrxiv_data.parquet")
Update Log
- 2025-03-16: Dataset updated; future updates will occur monthly.
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