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# Developments in local anaesthetic drugs
<|conv|>
## 65 88 The commercial preparation has an enantiomeric purity of 99.5%. 44 Ropivacaine Ropivacaine ( N- n- propyl 2 ¢,6 ¢- pipecoloxylidide) is an amino- amide local anaesthetic, some important basic aspects of which have been described already. It was ®rst registere... |
# Microinvasive squamous carcinoma of the cervix: treatment modalities.
<|conv|>
## In 1994 FIGO ( International Federation of Gynecology and Obstetrics) defined microinvasive squamous cell carcinoma of the uterine cervix as a microscopic lesion that invaded below the basement membrane to a maximum depth of 5 mm and ... |
# Microinvasive squamous carcinoma of the cervix: treatment modalities.
<|conv|>
## Therefore, it seems prudent to treat patients exhibiting such adverse parameters more aggressively. Some authors consider confluent tumor growth and poor cell differentiation as risk factors for nodal metastases and recurrence. Howeve... |
# Microinvasive squamous carcinoma of the cervix: treatment modalities.
<|conv|>
## Alternatively, a safer option in the presence of extensive LVSI may be to perform a radical trachelectomy and pelvic lymph node dissection ( Fig. 1) .
In a review of the literature, Ostor (3) reported on 674 patients with microinva... |
# Diagnosis of invasive candidiasis in the ICU
<|conv|>
## reported a significant decrease of the colonization index in critically ill patients empirically treated with caspofungin after recurrent gastrointestinal perforation/anastomotic leakage or acute necrotizing pancreatitis [60] .
Although these observations s... |
# ELECTROCARDIOGRAPHIC CHANGES IN CHRONIC COR PULMONALE
<|conv|>
## Electrocardiographic abnormalities have long been noted in cases of heart failure due to chronic cor pulmonale but there has been much discussion about their diagnostic importance and their causation. This paper is a study of a small series of cases o... |
# ELECTROCARDIOGRAPHIC CHANGES IN CHRONIC COR PULMONALE
<|conv|>
## (1948) (1949) showed by intracardiac and cesophageal leads that aVR showed an R wave in right ventricular hypertrophy which they suggested was probably due to late activation of the right ventricular wall and the observations of Sodi- Pallares et al. ... |
# ELECTROCARDIOGRAPHIC CHANGES IN CHRONIC COR PULMONALE
<|conv|>
## In the remaining case the tracing was not diagnostic, showing only rather low voltage curves, right axis deviation, a vertical heart with moderate clockwise rotation, and a small R in aVR only half the size of the Q wave; no V3 R was taken: this case ... |
# Correlates of Urinary Albumin Excretion in Young Adult Blacks and Whites: The Coronary Artery Risk Development in Young Adults Study
<|conv|>
## Microalbuminuria, the excretion of albumin in the urine at a level above the normal range but below the level of macroalbuminuria, is common in both hypertension and diabet... |
# Correlates of Urinary Albumin Excretion in Young Adult Blacks and Whites: The Coronary Artery Risk Development in Young Adults Study
<|conv|>
## Based on the average of the year 10 A/kC and the year 15 A/kC, 2,400 of the 2,582 participants included in these analyses had normal albuminuria and 182 had higher albumin ... |
# Treatment recommendations from the Eighth International Workshop on Waldenstroms Macroglobulinemia
<|conv|>
## Waldenström macroglobulinemia ( WM) is a lymphoplasmacytic lymphoma in which the bone marrow ( BM) is infiltrated by immunoglobulin M ( IgM)- producing clonal lymphoplasmacytic cells. 1 At the Second Intern... |
# Treatment recommendations from the Eighth International Workshop on Waldenstroms Macroglobulinemia
<|conv|>
## 21 An association between a specific polymorphism in the IgG Fc receptor ( FcgRIIIa- V158 F) and LON has been described. 22 Ofatumumab. Ofatumumab is a fully human CD20- directed monoclonal antibody that ta... |
# Treatment recommendations from the Eighth International Workshop on Waldenstroms Macroglobulinemia
<|conv|>
## After a minimum follow- up of 32 months, the median PFS was 42 months, 3- year DOR for patients with PR was 70%, and 3- year survival was 81%.
In the previous IWWM recommendations, the panel noted that n... |
# Treatment recommendations from the Eighth International Workshop on Waldenstroms Macroglobulinemia
<|conv|>
## Among patients who received reducedintensity allogeneic SCT, similar PFS and OS rates were observed (49% and 64%, respectively). NRM at 3 years was high at 33% for myeloablative transplantation and 23% for ... |
# Optimal protocol for total body irradiation for allogeneic bone marrow transplantation in mice
<|conv|>
## It is unlikely that the ( B6 →C3 H) mice died of severe GVHD caused by donor T cells, because no T cell infiltration was observed in recipient tissues, such as the spleen, liver or skin ( data not shown). As sh... |
# Repeated treatments with rituximab in a patient with amyloid- like IgM deposition neuropathy
<|conv|>
## Amyloid- like immunoglobulin M ( IgM) deposition neuropathy associated with Waldenström macroglobulinemia is a rare phenotype of IgM- related neuropathy. The prominent clinical features are painful sensory- domin... |
# Age related cognitive decline: a clinical entity? A longitudinal study of cerebral blood flow and memory performance.
<|conv|>
## These two ROIs corresponded to the posterior regions of pronounced hypoperfusion in patients with Alzheimer' s disease, and their delineation was based on the experience of one of us ( P... |
# Phospholipase D- derived phosphatidic acid is involved in the activation of the CD11 b/CD18 integrin in human eosinophils
<|conv|>
## Human eosinophils are potent effector cells in the host defence against invading ( micro)- organisms, particularly in the killing of helminths [1, 2] . It has also been demonstrated t... |
# Phospholipase D- derived phosphatidic acid is involved in the activation of the CD11 b/CD18 integrin in human eosinophils
<|conv|>
## [13] , with minor modifications. In short, eosinophils (5 i10' \ml) in incubation medium without HSA were incubated for 60 min at 37 mC with 5 µCi\ml of [$ H] lyso- PAF. Thereafter, t... |
# Phospholipase D- derived phosphatidic acid is involved in the activation of the CD11 b/CD18 integrin in human eosinophils
<|conv|>
## Taken together, we have found that elevation of intracellular PA leads to enhanced adhesiveness of eosinophils via the CD11 b\CD18 integrin. Several other lipids were tested for their... |
# Breast cancer chemoprevention: little progress in practice?
<|conv|>
## In The Lancet, Jack Cuzick and colleagues report the fi rst results from IBIS- II ( International Breast cancer Intervention Study II), 1 in which 3864 postmenopausal women at high risk of breast cancer were randomly assigned to receive the pot... |
# Endovascular versus Surgical Preemptive Repair of Forearm Arteriovenous Fistula Juxta- Anastomotic Stenosis: Analysis of Data Collected Prospectively from 1999 to 2004
<|conv|>
## oth surgical revision and endovascular management are established treatment modalities for the preemptive repair of stenosis in arteriov... |
# Endovascular versus Surgical Preemptive Repair of Forearm Arteriovenous Fistula Juxta- Anastomotic Stenosis: Analysis of Data Collected Prospectively from 1999 to 2004
<|conv|>
## Intravascular stent deployment took place with self- expanding Wallstent- Uni stents ( Boston Scientific Medi- Tech, Natick, MA). Stent ... |
# Quality of life in adolescent patients with idiopathic scoliosis after brace treatment: A meta- analysis
<|conv|>
## Unexplained adolescents with idiopathic scoliosis ( AIS), a deformity of spine, presents as spinal scoliosis, vertebral rotation, and a flexible or rigid deformity of the spine in the frontal plane. [... |
# Quality of life in adolescent patients with idiopathic scoliosis after brace treatment: A meta- analysis
<|conv|>
## When relevant data had not been reported, we contacted the authors by email or in other ways to attempt to obtain the missing information.
The Newcastle- Ottawa Scale ( NOS), [17] a tool to assess ... |
# Benjamin Alcock and the Pudendal Canal
<|conv|>
## The anatomy of the pudendal nerve is complex and difficult to visualize ( Fig. 1 ). Similar to median nerve compression in the carpal tunnel at the wrist, entrapment of the pudendal nerve is believed to occur in a canal, the pudendal canal or Alcock' s canal, but th... |
# Benjamin Alcock and the Pudendal Canal
<|conv|>
## At the anterior border of the ischial tuberosity, the junction with the inferior pubic ramus, the nerve exits from the obturator fascial sheath ( exit of Alcock' s canal, or beginning of the anterior portion of the third stage of the pudendal artery) and proceeds su... |
# Prediction of BRCA1 germline mutation status in women with ovarian cancer using morphology- based criteria: identification of a BRCA1 ovarian cancer phenotype.
<|conv|>
## omen with BRCA1 germline mutation are at an increased risk of developing breast and ovarian cancer. Current management of mutation carriers requ... |
# Prediction of BRCA1 germline mutation status in women with ovarian cancer using morphology- based criteria: identification of a BRCA1 ovarian cancer phenotype.
<|conv|>
## One potential criterion for patient selection for BRCA1 mutation testing, besides age at onset and family history, is tumor histology. This can ... |
# Single- Port Bilateral Thoracscopic Dorsal Sympathectmy for Primary Hyperhidrosis: Long- Term Outcome
<|conv|>
## Preoperative planning was done by revision of the operative technique details, confirmation of the side for operation and preparation of the surgical tools.
In the majority of cases, the diagnosis of ... |
# Single- Port Bilateral Thoracscopic Dorsal Sympathectmy for Primary Hyperhidrosis: Long- Term Outcome
<|conv|>
## In our study, the incidence of compensatory hyperhidrosis was 2% ( n = 2) we investigate this very low rate of CS in our series but we couldn' t find any reasonable explanation for that.
Compensatory ... |
# Single- Port Bilateral Thoracscopic Dorsal Sympathectmy for Primary Hyperhidrosis: Long- Term Outcome
<|conv|>
## [4] reported four cases (0.3%), Schmidt et al. [46] , one case (0.5%). Lin et al. [47] reported on two cases (0.1%) of hemothorax, with one requiring chest tube drainage. Doolabh et al. [48] reported on ... |
# Paliperidone extended- release: does it have a place in antipsychotic therapy?
<|conv|>
## Paliperidone is the active metabolite of the widely used second- generation antipsychotic, risperidone, is the generic name for 9- hydroxy- risperidone. On December 20, 2006 , palperidone was approved for the acute and mainte... |
# Paliperidone extended- release: does it have a place in antipsychotic therapy?
<|conv|>
## Their efficacy, as well as their side effect profile, is variable. In relation to first- generation antipsychotics, each second- generation antipsychotic needs to be seen on its own merits. A number of credible studies and me... |
# Paliperidone extended- release: does it have a place in antipsychotic therapy?
<|conv|>
## 25 Due to looser binding to D 2 receptors and lower fluctuations of levels in plasma, 26 PER is theoretically associated with a lower risk of extrapyramidal side effects than risperidone. 23 Therefore, PER can be seen as havi... |
# Paliperidone extended- release: does it have a place in antipsychotic therapy?
<|conv|>
## 34, 38 Although hepatic metabolism is present to some degree, renal excretion seems to be the primary route of elimination for paliperidone, with 59% of the oral dose excreted unchanged in the urine. 38 About half of the rena... |
# Paliperidone extended- release: does it have a place in antipsychotic therapy?
<|conv|>
## 52, 53 The accumulated study population was divided into two groups with either recently diagnosed schizophrenia ( defined as time since diagnosis up to three years) or not recently diagnosed schizophrenia ( defined as time s... |
# Paliperidone extended- release: does it have a place in antipsychotic therapy?
<|conv|>
## Furthermore, prolactin shows lower peaks on PER than on risperidone. Lower serum peak levels of the active substance, as well as of prolactin, may be the reason for the low incidence of prolactin- related side effects in spit... |
# Using laser capture microdissection to study fiber specific signaling in locomotor muscle in COPD: A pilot study
<|conv|>
## ABSTRACT: Introduction: Quadriceps dysfunction is important in chronic obstructive pulmonary disease ( COPD), with an associated increased proportion of type II fibers. Investigation of protei... |
# Using laser capture microdissection to study fiber specific signaling in locomotor muscle in COPD: A pilot study
<|conv|>
## Whole muscle sample analyses did not reveal significant differences between COPD and control subjects for any of the target genes analyzed ( Fig. 3) . For laser captured samples, we analyzed e... |
# Using laser capture microdissection to study fiber specific signaling in locomotor muscle in COPD: A pilot study
<|conv|>
## In addition, this technique provides more sensitive analyses, showing differences in gene expression in specimens enriched by fiber type where no significant differences could be detected in w... |
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