input large_stringlengths 417 1.69k | output large_stringclasses 2
values | ntokens uint32 102 505 | task large_stringclasses 11
values | SMILES large_stringlengths 2 448 | embeddings sequence |
|---|---|---|---|---|---|
Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 151 | butkiewicz | Clc1cc(NC(=O)CCCCCN2C(=O)CCC2=O)ccc1OC | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 170 | butkiewicz | Clc1ccc(c2nc(sc2)n2[nH]c(c(c2=O)C(/O)=C/C(=O)C)C)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 159 | butkiewicz | S(=O)(=O)(c1c(n2ncc(c2nc1)c1ccc(F)cc1)N)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 172 | butkiewicz | S(=O)(=O)(Nc1nc2c(nc1Nc1c(n(n(c1=O)c1ccccc1)C)C)cccc2)c1sccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 145 | butkiewicz | S1C(CC(OC)=O)C(=O)NC1=O | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 150 | butkiewicz | O(CCCOc1c(OC)cccc1OC)c1c(OC)cccc1OC | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 154 | butkiewicz | O(C(C)C(OCC)=O)c1nn(c2ccccc2)c(=O)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 157 | butkiewicz | s1c(ccc1C)/C=N\NC(=O)c1c2c([nH]c1)cccc2 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 163 | butkiewicz | O(c1c(C(NC(=O)C)c2c(O)c3ncccc3cc2)ccc(OC)c1)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 169 | butkiewicz | s1c(NC(c2n(c3c(n2)cc(cc3)C(F)(F)F)CCOCCO)C)nc(c1)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 167 | butkiewicz | s1c2c(n(Cc3occc3)c1=S)nc(SCC#N)n(c2=O)c1ccc(F)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 143 | butkiewicz | O=C(NCCCN1CCCCCC1)/C=N\O | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 166 | butkiewicz | o1c2c(c(=O)c(Oc3c(OCC)cccc3)c1C)ccc(OC(=O)c1occc1)c2 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 170 | butkiewicz | O(c1n(c2c(n(c(=O)n(c2=O)C)C)n1)Cc1ccccc1)c1ccc(OC)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 167 | butkiewicz | FC(F)(F)c1cc(NC(=O)c2cc(NC(=O)c3ccc(nc3)N)cc(OC)c2)ccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 168 | butkiewicz | S(c1n(c2c(n(c(=O)[nH]c2=O)C)n1)CCOCC)CC(OCc1ccccc1)=O | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 155 | butkiewicz | S(c1n(c2c(OC)cccc2)cnn1)CC(=O)NCc1sccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 157 | butkiewicz | O=C(NCCCc1n(c2c(n1)cccc2)Cc1ccc(cc1)C)C | [
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0.1411124765... |
Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 172 | butkiewicz | FC(F)(F)c1n(N\C=C2\C(=O)CC(CC2=O)(C)C)c(=O)c2c(n1)cccc2 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 146 | butkiewicz | O1C(CCC1)Cn1c(c2ccccc2)cnc1N | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 155 | butkiewicz | s1cc(nc1Nc1ccc(cc1)C)c1n2c(nc1C)nccc2 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 163 | butkiewicz | S=C(NC1=C(C(Cc2c1cccc2)(C)C)C(OCC)=O)NC(=O)c1ccccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 158 | butkiewicz | O=c1n(CC(=O)NCCC(=O)NCc2ccc(cc2)C)ccc2c1cccc2 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 150 | butkiewicz | Brc1c(cc(OCC(=O)NCCN2CCOCC2)cc1C)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 184 | butkiewicz | FC(F)(F)C1(C2=C(N(C1=O)c1ccccc1)CC(CC2=O)(C)C)c1c([nH]n(c1=O)c1ccccc1)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 163 | butkiewicz | O=c1n(n(c(c1Nc1ncnc2n(ncc12)c1ccccc1)C)C)c1ccccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 187 | butkiewicz | O=C1C(C2C=3C(n4n(C(C13)C)c(=O)n(c4=O)c1ccccc1)CC(CC2C(OC)=O)C(OC)=O)(CC)CC | [
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0.0098190456628... |
Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 155 | butkiewicz | S(=O)(=O)(NC(CC)C)c1ccc(OCC(=O)N2CCCC2)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 169 | butkiewicz | FC(F)(F)C1(O)N(N=C(C1)C)C(=O)c1oc(Cn2nc(cc2C)C)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 155 | butkiewicz | Clc1ccc(COc2c(C(OCC(=O)NC3CC3)=O)cccc2)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 164 | butkiewicz | s1c(c(c(c1NC(=O)/C=C\c1cc2OCOc2cc1)C(OCC)=O)C)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 172 | butkiewicz | O=C(N1CCN(CC1)c1c(c(ccc1)C)C)Cn1nc(c2c(c1=O)cccc2)Cc1ccncc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 151 | butkiewicz | OC(=O)c1c(NCc2ccc(cc2)C(O)=O)cccc1 | [
0.20783200860023499,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 164 | butkiewicz | S(c1n(CCCCC)c2c(n(c(=O)[nH]c2=O)C)n1)CCc1ccccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 162 | butkiewicz | O1c2cc(CNc3n4c(nc3c3ccc(O)cc3)cc(cc4)C)ccc2OC1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 161 | butkiewicz | Clc1c(N(S(=O)(=O)C)CC(OC)=O)cc(cc1)C(F)(F)F | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 172 | butkiewicz | S(c1nc(N)c(c(C(C)C)c1C#N)C#N)CC(=O)c1cc2c(oc1=O)cccc2 | [
0.15885739028453827,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 176 | butkiewicz | O=C(N\N=C/c1c(n(nc1)CC)C)c1c2c(nc(c3c(cc(cc3)C)C)c1)cccc2 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 143 | butkiewicz | s1c(NC(=O)C2CCCC2)ncc1C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 156 | butkiewicz | S(=O)(=O)(NCC(O)=O)c1c(cc(c(c1)C)C)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 164 | butkiewicz | S(=O)(=O)(N(Cc1cccnc1)Cc1occc1)c1cc(OC)c(n2nnnc2)cc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 172 | butkiewicz | S(=O)(=O)(N1CCOCC1)c1cc2c(oc(c2C)C(=O)NCCc2cc(OC)c(OC)cc2)cc1 | [
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0.00938594... |
Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 158 | butkiewicz | O=c1n(nc2c3c(c4c2cccc4)cccc13)c1ccc(cc1)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 163 | butkiewicz | O(\N=C(/N)c1cc([N+]([O-])=O)ccc1)C(=O)c1cc(ccc1)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 164 | butkiewicz | s1c(nnc1NC(=O)c1c2c(nc(c1)c1ccccc1)cccc2)CC(C)(C)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 174 | butkiewicz | S(C(C(=O)Nc1c(n(n(c1=O)c1ccccc1)C)C)C)c1nc2c(c(c1)C)cccc2 | [
0.148593932390213,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 162 | butkiewicz | S(=O)(=O)(N1CC(CCC1)C(=O)NCCC=1CCCCC1)c1c2ncccc2ccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 150 | butkiewicz | Fc1ccc(c2nn3c(cc(nc3n2)C)C)cc1 | [
0.21095284819602966,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 158 | butkiewicz | O1CCN(CC1)c1[nH]c(c(CCC(C)C)c(=O)n1)C | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 160 | butkiewicz | S(c1n(c(nn1)Cc1sccc1)CC=C)CC(=O)Nc1cc(OC)ccc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 157 | butkiewicz | O=C(NC1CCCCC1)Nc1cc2nc(n(c2cc1)C)CCN1CCCCC1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 155 | butkiewicz | O=C(NCCO)C(/NC(=O)/C=C\c1ccccc1)=C\c1ccccc1 | [
0.06389021873474121,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 165 | butkiewicz | S(=O)(=O)(N(CCOC)CCOC)c1ccc(cc1)C(=O)Nc1scc(n1)c1ccncc1 | [
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 161 | butkiewicz | s1c2c(=O)n(CCC(=O)Nc3ccc(OCC)cc3)c(=O)[nH]c2cc1 | [
0.2689359784126282,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 156 | butkiewicz | o1c2c(c(c(CCC(OCC)=O)c1=O)C)ccc(O)c2 | [
0.5056257247924805,
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Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 170 | butkiewicz | S(CC(=O)c1ccc(C(C)C)cc1)c1[nH]c2nc(cc(c2c(=O)n1)C)C | [
0.15361587703227997,
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-0.334287822246... |
Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 174 | butkiewicz | O1CCN(CC1)c1c([N+]([O-])=O)cc(cc1)C(=O)Nc1ccc(c2oc3c(n2)cccc3)cc1 | [
0.3823945224285126,
-0.26523441076278687,
-0.12147869169712067,
0.21817593276500702,
-0.025907084345817566,
-0.10579338669776917,
-0.08493277430534363,
-0.004491137340664864,
-0.044233933091163635,
0.31535202264785767,
0.02036173641681671,
-0.05613582581281662,
-0.09902983158826828,
0.1210... |
Instructions: Answer the following question about drug properties.
Context: Cav3 T-type calcium channels are voltage-gated calcium channels that have low activation voltage, rapid inactivation, and small single channel conductance. They are found in neurons, cardiac tissue, and various other cell types. They are involv... | (A) | 172 | butkiewicz | O(c1c2C3(CC4N(CCc(c24)cc1OC)C(=O)c1ccccc1)C=CC(=O)C=C3)C | [
0.52895188331604,
-0.22238567471504211,
-0.35401496291160583,
0.17455583810806274,
0.03674359619617462,
-0.11078198999166489,
0.0909714475274086,
0.1868896186351776,
-0.1984233558177948,
0.11013700067996979,
0.11018016934394836,
-0.053552351891994476,
0.041826680302619934,
0.00641687214374... |
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