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25985014
We investigated the role of surgical ablation targeting the autonomous nervous system during a Cox-Maze IV procedure in the maintenance of sinus rhythm at long-term follow-up. The patient population consisted of 519 subjects with persistent or long-standing persistent atrial fibrillation (AF) undergoing radiofrequency ...
Is ganglionated plexi ablation during Maze IV procedure beneficial for postoperative long-term stable sinus rhythm?
No. GP ablation did not prove to be beneficial for postoperative stable NSR. A complete left atrial lesion set and biatrial ablation are advisable for improving rhythm outcomes. Randomized controlled trials are necessary to confirm our findings.
PASS
pubmedQA
1
16195477
Obesity is associated with an increased risk for cardiovascular disease. Although it is known that white adipose tissue (WAT) produces numerous proinflammatory and proatherogenic cytokines and chemokines, it is unclear whether adipose-derived chemotactic signals affect the chronic inflammation in atherosclerosis. Histo...
Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis?
Yes. Human pWAT has chemotactic properties through the secretion of different chemokines, and we propose that pWAT might contribute to the progression of obesity-associated atherosclerosis.
PASS
pubmedQA
1
12848629
Tuberculosis has increased in parallel with the acquired immunodeficiency syndrome epidemic and the use of immunosuppressive therapy, and the growing incidence of extra-pulmonary tuberculosis, especially with intestinal involvement, reflects this trend. However, the duration of anti-tuberculous therapy has not been cla...
Is a 9-month treatment sufficient in tuberculous enterocolitis?
Yes. Tuberculous enterocolitis can be managed by 9-month chemotherapy without disease recurrence. Further investigations are needed in immunocompromised patients.
PASS
pubmedQA
1
20594006
Tethering of the spinal cord is thought to increase the chance of neurological injury when scoliosis correction is undertaken. All patients with myelomeningocele (MM) are radiographically tethered, and untethering procedures carry significant morbidity risks including worsening neurological function and wound complicat...
A patient with myelomeningocele: is untethering necessary prior to scoliosis correction?
No. The study results suggested that spinal cord untethering may be unnecessary in patients with MM who are undergoing scoliosis corrective surgery and do not present with clinical symptoms of a tethered cord, even though tethering is radiographically demonstrated.
PASS
pubmedQA
1
15995461
This article examines the hypothesis that the six U.S. states with the highest rates of road traffic deaths (group 1 states) also had above-average rates of other forms of injury such as falling, poisoning, drowning, fire, suffocation, homicide, and suicide, and also for the retail trade and construction industries. Th...
Do some U.S. states have higher/lower injury mortality rates than others?
Yes. Group 1 states are likely to exhibit above-average rates for most other categories of injury death, whereas group 2 states are even more likely to exhibit below-average rates for most other categories of injury death.
PASS
pubmedQA
1
24013712
Platelet count is inversely related to prognosis in many cancers; however, its role in esophageal cancer is still controversial. The purpose of this study was to determine the prognostic value of preoperative platelet count in esophageal squamous cell carcinoma (ESCC). From January 2006 to December 2008, a retrospectiv...
Preoperative platelet count in esophageal squamous cell carcinoma: is it a prognostic factor?
Yes. Preoperative platelet count is a predictive factor for long-term survival in ESCC, especially in nodal-positive patients. We conclude that 205 (×10(9)/L) may be the optimum cutoff point for platelet count in predicting survival in ESCC patients.
PASS
pubmedQA
1
25675614
Diabetes mellitus (DM) is undiagnosed in approximately half of the patients actually suffering from the disease. In addition, the prevalence of DM is more than twice as high as in patients with periodontitis when compared to periodontally healthy subjects. Thus, a high number of patients with periodontitis may have und...
Can gingival crevicular blood be relied upon for assessment of blood glucose level?
Yes. The data from this study has shown that GCB collected during diagnostic periodontal examination can be an excellent source of blood for glucometric analysis.
PASS
pubmedQA
1
24684514
Optimization of the preoperative hemoglobin (Hb) level is an effective way to reduce allogeneic transfusion in total knee arthroplasty (TKA) though the procedure is expensive, requires close monitoring and is often inconvenient for patients with reduced mobility. Our aim was to investigate the value of preoperative Hb ...
Should all patients be optimized to the same preoperative hemoglobin level to avoid transfusion in primary knee arthroplasty?
No. Not all the patients undergoing TKA who receive tranexamic acid need the same preoperative Hb optimization target. Two easily available factors, such as the ASA score and the Hb level, can help individualize the Hb optimization target.
PASS
pubmedQA
1
9142039
To assess the relationship between the experience of pediatric housestaff and tests ordered on infants in the neonatal intensive care unit (ICU). Prospective, cohort study over one full academic year. One academic Level III neonatal intensive care nursery. Data were collected prospectively on all 785 infants admitted t...
Does pediatric housestaff experience influence tests ordered for infants in the neonatal intensive care unit?
Yes. Interns order significantly more arterial blood gases per infant than junior and senior residents on-call in the neonatal ICU. Additional study is required to see if the experience of housestaff is associated with a broader array of neonatal outcomes, such as morbidity and mortality.
PASS
pubmedQA
1
17342562
Some patients with suspected common bile duct (CBD) stones are found to have sludge and no stones. Although sludge in the gallbladder is a precursor of gallbladder stones, the significance of bile duct sludge (BDS) is poorly defined. This study aimed to compare BDS with bile duct stones in terms of frequency, associate...
The clinical significance of bile duct sludge: is it different from bile duct stones?
No. The findings indicate that the clinical significance of symptomatic BDS is similar to that of CBD stones. Bile duct sludge seems to be an early stage of choledocholithiasis.
PASS
pubmedQA
1
20401819
Ultrasound is currently not established for the diagnosis of fractures. The aim of this study was to compare ultrasound and X-ray beyond their use solely for the identification of fractures, i. e., for the detection of fracture type and dislocation for pediatric fracture diagnosis. Limb bones of dead young pigs served ...
Is ultrasound equal to X-ray in pediatric fracture diagnosis?
Yes. Ultrasound not only has comparable sensitivity to that of X-ray for the identification of limb fractures but is also equally effective for the diagnosis of fracture type and dislocation. Thus, ultrasound can be used as an adequate alternative method to X-ray for pediatric fracture diagnosis.
PASS
pubmedQA
1
24073931
In recent years, many advances in pancreatic surgery have been achieved. Nevertheless, the rate of pancreatic fistula following pancreatic tail resection does not differ between various techniques, still reaching up to 30% in prospective multicentric studies. Taking into account contradictory results concerning the use...
Is the covering of the resection margin after distal pancreatectomy advantageous?
No. The results show no significant difference in the fistula rate after covering of the resection margin after distal pancreatectomy, which contributes to the picture of an unsolved problem.
PASS
pubmedQA
1
26471488
Limited and conflicting data exist on an association between mammographic density (MD) and re-excision rates after breast-conserving surgery (BCS). Additionally, the correlation of MD with resection of unnecessary margins during initial BCS is unknown. All women with a diagnosis of breast cancer from 2003 to 2012 and e...
Does Mammographic Density have an Impact on the Margin Re-excision Rate After Breast-Conserving Surgery?
No. Mammographic density is not associated with an increased need for re-excision or resection of unnecessary margins at initial BCS.
PASS
pubmedQA
1
17565137
To evaluate the effect of an antismoking advertisement on young people's perceptions of smoking in movies and their intention to smoke.SUBJECTS/ 3091 cinema patrons aged 12-24 years in three Australian states; 18.6% of the sample (n = 575) were current smokers.DESIGN/ Quasi-experimental study of patrons, surveyed after...
Out of the smokescreen II: will an advertisement targeting the tobacco industry affect young people's perception of smoking in movies and their intention to smoke?
Yes. This real-world study suggests that placing an antismoking advertisement before movies containing smoking scenes can help to immunise non-smokers against the influences of film stars' smoking. Caution must be exercised in the type of advertisement screened as some types of advertising may reinforce smokers' intent...
PASS
pubmedQA
1
17715311
The purpose of this study was to evaluate the clinical usefulness of a fetal anatomic survey on follow-up antepartum sonograms. A retrospective follow-up study was conducted at a low-risk maternity clinic from July 1, 2005, to June 30, 2006. Eligible women had at least 1 prior sonographic examination beyond 18 weeks' g...
Is fetal anatomic assessment on follow-up antepartum sonograms clinically useful?
Yes. A fetal anatomic survey on follow-up sonograms may identify unanticipated fetal anomalies, especially when the indication is for fetal growth.
PASS
pubmedQA
1
17551944
To determine whether spectral Doppler measurements obtained from bilateral uterine, arcuate, radial, and spiral arteries in early gestation correlate with adverse pregnancy outcome. One hundred five pregnant women underwent transvaginal Doppler sonographic examination of uteroplacental circulation at 6-12 weeks' gestat...
Doppler examination of uteroplacental circulation in early pregnancy: can it predict adverse outcome?
Yes. Transvaginal Doppler examination can detect hemodynamic changes in uteroplacental circulation associated with subsequent adverse pregnancy outcome.
PASS
pubmedQA
1
10456814
Although desflurane is commonly used to control surgically induced hypertension, its effects on left ventricular (LV) function have not been investigated in this clinical situation. The purpose of the present study was to evaluate the LV function response to desflurane, when used to control intraoperative hypertension....
Does desflurane alter left ventricular function when used to control surgical stimulation during aortic surgery?
No. This study demonstrates that in patients at risk for cardiac morbidity undergoing vascular surgery, desflurane is effective to control intraoperative hypertension without fear of major cardiac depressant effect.
PASS
pubmedQA
1
9582182
To investigate the relevance of the Symptom Checklist 90-R Obsessive-Compulsive subscale to cognition in individuals with brain tumor. A prospective study of patients assessed with a neuropsychological test battery. A university medical center. Nineteen adults with biopsy-confirmed diagnoses of malignant brain tumors w...
Does the SCL 90-R obsessive-compulsive dimension identify cognitive impairments?
Yes. Our data suggest that the SCL 90-R is best viewed as an indicator of unidimensional emotional distress and somatic effects of structural brain injury.
PASS
pubmedQA
1
24359102
Skin diseases are the most frequently recognized occupational diseases in Denmark. The prognosis for occupational contact dermatitis is often poor. To investigate the prognosis, assessed by eczema, job status and skin-related quality of life, among patients allergic to rubber chemicals and latex (ubiquitous allergens) ...
Two-year follow-up survey of patients with allergic contact dermatitis from an occupational cohort: is the prognosis dependent on the omnipresence of the allergen?
Yes. At follow-up, patients with contact urticaria had significantly poorer prognosis than those with contact allergy, and there was a trend towards a poorer prognosis for those with contact allergy to rubber chemicals than those with allergy to epoxy. A significant positive association between job change and improveme...
PASS
pubmedQA
1
22668712
The aim of this study was to assess the diagnostic value of articular sounds, standardized clinical examination, and standardized articular ultrasound in the detection of internal derangements of the temporomandibular joint. Forty patients and 20 asymptomatic volunteers underwent a standardized interview, physical exam...
Internal derangement of the temporomandibular joint: is there still a place for ultrasound?
No. The present study does not support the recommendation of ultrasound as a conclusive diagnostic tool for internal derangements of the temporomandibular joint.
PASS
pubmedQA
1
15708048
To determine the effect of prior benign prostate biopsies on the surgical and clinical outcomes of patients treated with radical perineal prostatectomy for prostate cancer. A total of 1369 patients with clinically localized prostate cancer underwent radical prostatectomy by a single surgeon between 1991 and 2001. A sub...
Does prior benign prostate biopsy predict outcome for patients treated with radical perineal prostatectomy?
Yes. A prior benign prostate biopsy may be independently associated with more favorable surgical and biochemical outcomes after prostatectomy. Additional studies are needed to confirm these findings.
PASS
pubmedQA
1
22513023
To assess whether Indigenous Australians age prematurely compared with other Australians, as implied by Australian Government aged care policy, which uses age 50 years and over for population-based planning for Indigenous people compared with 70 years for non-indigenous people. Cross-sectional analysis of aged care ass...
Do Indigenous Australians age prematurely?
No. The idea that Indigenous people age prematurely is not well supported by this study of a series of discrete conditions. The current focus and type of services provided by the aged care sector may not be the best way to respond to the excessive burden of chronic disease and disability of middle-aged Indigenous peopl...
PASS
pubmedQA
1
21194998
Minimal access surgery (MAS) in adults is associated with less postoperative pain in comparison to conventional 'open' surgery. It is not known whether this holds true for neonates as well. Less pain would imply that opioid consumption can be reduced, which has a beneficial effect on morbidity.AIM: To evaluate potentia...
Does minimal access major surgery in the newborn hurt less?
No. Minimal access surgery for the repair of esophageal atresia or congenital diaphragmatic hernia is not associated with less cumulative opioid doses.
PASS
pubmedQA
1
25521278
Identifying eating behaviors which contribute to excess weight gain will inform obesity prevention strategies. A tendency to clear one's plate when eating may be a risk factor for obesity in an environment where food is plentiful. Whether plate clearing is associated with increased body weight in a cohort of US partici...
Is plate clearing a risk factor for obesity?
Yes. The tendency to clear one's plate when eating is associated with increased body weight and may constitute a risk factor for weight gain.
PASS
pubmedQA
1
12153648
Women's experiences of childbirth may affect their future reproduction, and the model of care affects their experiences, suggesting that a causal link may exist between model of care and future reproduction. The study objective was to examine whether the birth center model of care during a woman's first pregnancy affec...
Does birth center care during a woman's first pregnancy have any impact on her future reproduction?
No. A woman's model of care, such as birth center care, during her first pregnancy does not seem to be a sufficiently important factor to affect subsequent reproduction in Sweden.
PASS
pubmedQA
1
22382608
The differential diagnosis between essential tremor (ET) and Parkinson's disease (PD) may be, in some cases, very difficult on clinical grounds alone. In addition, it is accepted that a small percentage of ET patients presenting symptoms and signs of possible PD may progress finally to a typical pattern of parkinsonism...
SPECT study with I-123-Ioflupane (DaTSCAN) in patients with essential tremor. Is there any correlation with Parkinson's disease?
No. Our results do not support the hypothesis of a link between essential tremor and Parkinson's disease. However, it appears that ET patients have a small degree of striatal dopaminergic degeneration. If this is due to alterations in the nigrostriatl pathway or of other origin it is not clear. Follow-up studies of ess...
PASS
pubmedQA
1
16564683
To evaluate the accuracy of ultrasonographic examination in boys with an undescended testis. All patients who were referred to the paediatric surgeon after detection of an undescended testis were evaluated prospectively between November 2001 and November 2004. Among these 377 patients, 87 were referred with an ultrason...
Is there any interest to perform ultrasonography in boys with undescended testis?
No. Sonography has no place in the diagnosis of undescended testis.
PASS
pubmedQA
1
18603989
Embalming is the through disinfection and art of preserving bodies after death using chemical substances. It keeps a body life like in appearance during the time it lies in a state prior to funeral. This study was undertaken to investigate the effectiveness of Raksi in sacrificed rats in arresting postmortem changes an...
Can homemade alcohol (Raksi) be useful for preserving dead bodies?
Yes. It is concluded from the study that this knowledge if applied to dead human subjects, may preserve dead bodies temporarily allowing delayed funeral.
PASS
pubmedQA
1
20130378
Congenital cytomegalovirus infection is currently the leading cause of congenital infection in 0.2-2.2% of live births worldwide leading to variable serious sequalae. The aim of the study was to determine if low birth weight is an indicator of CMV congenital infection evidenced by detecting CMV-DNA in umbilical cord bl...
Is low birth weight a risk indicator for congenital cytomegalovirus infection?
No. CMV-IgM and IgG antibodies assessment was not a potential discriminative test to identify congenitally infected newborns. In addition, low birth weight and small head circumference at birth failed to predict congenital CMV infection. CMV-DNA detection in umbilical cord blood at the time of delivery using real-time ...
PASS
pubmedQA
1
27832831
Poor bone quality and unstable fractures increase the cut-out rate in implants with gliding lag screws. The U-Blade (RC) lag screw for the Gamma3®nail was introduced to provide monoaxial rotational stability of the femoral head and neck fragment. The purpose of this study was to evaluate whether the use of the U-Blade ...
Does an additional antirotation U-Blade (RC) lag screw improve treatment of AO/OTA 31 A1-3 fractures with gamma 3 nail?
No. In our study the U-Blade (RC) lag screw did not reduce the cut-out in treatment of OTA/AO 31A1-3 fractures at all. Considering the longer duration of surgery and the higher costs of the U-Blade (RC) lag screw, our results do not justify its use. However, further prospective randomized studies will be necessary.
PASS
pubmedQA
1
23719685
The present analysis compares two palliative treatment concepts for lung cancer in terms of overall survival. Survival data from 207 patients were used in a retrospective analysis. All patients received palliative treatment comprising either 25 Gy applied in 5 fractions or 50 Gy in 20 fractions. A subgroup analysis was...
Does high-dose radiotherapy benefit palliative lung cancer patients?
No. The palliative treatment concept of 25 Gy applied in 5 fractions is sufficient for radiation of lung cancer, given that there was no obvious survival improvement in patients treated with the higher total dose regimen.
PASS
pubmedQA
1
24958650
Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID). Overall, 44 patients with PID and 44 healthy women were included in the study. The control group consisted of 44 women who applied to the clinic for a routine ...
May mean platelet volume levels be a predictor in the diagnosis of pelvic inflammatory disease?
Yes. Since the MPV value was significantly decreased in patients with PID, it may serve as an additional and even more valuable marker than leukocyte count in the diagnosis of PID.
PASS
pubmedQA
1
24739448
In January 2008, the Food and Drug Administration (FDA) communicated concerns and, in May 2009, issued a warning about an increased risk of suicidality for all antiepileptic drugs (AEDs). This research evaluated the association between the FDA suicidality communications and the AED prescription claims among members wit...
Have antiepileptic drug prescription claims changed following the FDA suicidality warning?
No. During the time period considered, the FDA AED-related suicidality warning does not appear to have significantly affected prescription claims of AED medications for the study population.
PASS
pubmedQA
1
25168472
The intent of this study was to determine if the use of a single or combination of static foot posture measurements can be used to predict rearfoot, midfoot, and forefoot plantar surface area in individuals with pronated or normal foot types. Twelve foot measurements were collected on 52 individuals (mean age 25.8 year...
Can static foot posture measurements predict regional plantar surface area?
Yes. The results indicate that clinicians can use a combination of simple, reliable and time efficient foot measures to explain 79% and 85% of the plantar surface area in the forefoot and midfoot, respectively.
PASS
pubmedQA
1
17445978
To evaluate renal damage and impairment of renal function 1 yr after laparoscopic partial nephrectomy (LPN) with warm ischemia>30 min. From July 2004 to June 2005, 18 patients underwent LPN with warm ischemia time>30 min. Kidney damage markers (daily proteinuria and tubular enzymes) and renal function (serum creatinine...
Is renal warm ischemia over 30 minutes during laparoscopic partial nephrectomy possible?
No. Our results demonstrate that kidney damage occurs during LPN when warm ischemia is>30 min. This damage is only partially reversible and efforts should be made to keep warm ischemia within 30 min.
PASS
pubmedQA
1
21368683
Patients diagnosed with serious mental illness (SMI) who qualify for nursing home placement tend to require high levels of both psychiatric and nursing care. However, it is unknown whether they are equally likely to be admitted to nursing homes with adequate quality of care compared with other patients. We analyzed a n...
Are patients with serious mental illness more likely to be admitted to nursing homes with more deficiencies in care?
Yes. Patients diagnosed with schizophrenia or bipolar disorder (ie, SMI) were more likely than other patients to be admitted to nursing homes with higher deficiency citations for both overall quality and clinical care quality. Further research is necessary to understand the reasons behind the disparity in quality of nu...
PASS
pubmedQA
1
18439500
To assess whether it is possible for an experienced laparoscopic surgeon to perform efficient laparoscopic myomectomy regardless of the size, number, and location of the myomas. Prospective observational study (Canadian Task Force classification II-1). Tertiary endoscopy center. A total of 505 healthy nonpregnant women...
Laparoscopic myomectomy: do size, number, and location of the myomas form limiting factors for laparoscopic myomectomy?
No. Laparoscopic myomectomy can be performed by experienced surgeons regardless of the size, number, or location of the myomas.
PASS
pubmedQA
1
15223779
This study was conducted to investigate the expression and functional impact of the proto-oncogene c-kit in uveal melanoma. Based on immunohistochemical (IHC) study of paraffin-embedded specimens from 134 uveal melanomas and Western blot analysis on eight fresh-frozen samples the expression of c-kit in uveal melanoma w...
c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target?
Yes. The results confirm that c-kit is vastly expressed in uveal melanoma, suggest that the c-kit molecular pathway may be important in uveal melanoma growth, and point to its use as a target for therapy with STI571.
PASS
pubmedQA
1
15488260
Rates of relapse and predictive relapse factors were studied over more than 4 years in a sample of Spanish outpatients with DSM-III-R criteria for unipolar major depressive episode. A final sample of 139 outpatient was followed monthly in a naturalistic study. The Structured Clinical Interview for DSM-III-R was used. P...
Is the type of remission after a major depressive episode an important risk factor to relapses in a 4-year follow up?
Yes. At medium term, relapse rates for a major depressive episode are high. Partial remission after a depressive episode seems to be an important predictive factor for relapses in a 4-year follow-up.
PASS
pubmedQA
1
14976655
The aim of this study was to evaluate poststapedectomy-delayed facial palsy etiopathogenesis, risk factors, evolution, and prevention. Seven hundred six stapedectomies performed in 580 patients were reviewed. In all patients who developed delayed facial palsy, the dates of onset and subside of facial palsy, the anatomi...
Delayed peripheral facial palsy in the stapes surgery: can it be prevented?
Yes. Poststapedectomy-delayed facial palsy is likely caused by a reactivation of HSV-1, latent within the geniculate ganglion. The activation of the latent virus is more frequent in patients with a history of herpes labialis and can be prevented by an adequate acyclovir therapy.
PASS
pubmedQA
1
21252642
Oncology literature cites that only 2% to 4% of patients participate in research. Up to 85% of patients are unaware that clinical trials research is being conducted at their treatment facility or that they might be eligible to participate. It was hypothesized that patients' satisfaction with information regarding clini...
Does increased patient awareness improve accrual into cancer-related clinical trials?
No. A set of educational interventions designed for cancer patients significantly improved their satisfaction with information on clinical research, but did not improve clinical trial enrollment of these participants as of 1 year after the study.
PASS
pubmedQA
1
19640728
Bias against operating on patients with prosthetic valve endocarditis (PVE) who have multiple prostheses may preclude the use of life-saving valve replacement. We investigated the accuracy of the preoperative diagnosis of PVE in patients with both mitral and aortic prosthesis and the safety of single-valve replacement ...
Surgical treatment of prosthetic valve endocarditis in patients with double prostheses: is single-valve replacement safe?
Yes. TEE allowed a diagnosis of site involvement that did correlate with the anatomic diagnosis obtained during the operation. This fact contributed to the management of patients and was of great help in guiding the surgical intervention. Echo-oriented single-valve replacement may be a safe strategy for patients with P...
PASS
pubmedQA
1
17916877
To determine the therapeutic effect (alleviation of vascular type headache) and side effects of a slow intravenous metoclopramide infusion over 15 min compared with those effects of a bolus intravenous metoclopramide infusion over 2 min in the treatment of patients with recent onset vascular type headache. All adults t...
Intravenous administration of metoclopramide by 2 min bolus vs 15 min infusion: does it affect the improvement of headache while reducing the side effects?
Yes. Slowing the infusion rate of metoclopramide is an effective strategy for the improvement of headache and reducing the incidence of akathisia in patients with vascular type headache.
PASS
pubmedQA
1
21558951
To ascertain whether level of intrauterine cocaine exposure (IUCE) is associated with early adolescent delinquent behavior, after accounting for prenatal exposures to other psychoactive substances and relevant psychosocial factors. Ninety-three early adolescents (12.5-14.5 years old) participating since birth in a long...
Are there effects of intrauterine cocaine exposure on delinquency during early adolescence?
No. In this cohort, prospectively ascertained prenatal exposure to cigarettes and childhood exposure to violence are associated with self-reported delinquent behaviors during early adolescence. Contrary to initial popular predictions, intrauterine cocaine is not a strong predictor of adolescent delinquent behaviors in ...
PASS
pubmedQA
1
21420186
Sporadic data present in literature report how preterm birth and low birth weight are risk factors for the development of cardiovascular diseases in later life. High levels of asymmetric dimethylarginine (ADMA), a strong inhibitor of nitric oxide synthesis, are associated with the future development of adverse cardiova...
Could ADMA levels in young adults born preterm predict an early endothelial dysfunction?
Yes. Our findings reveal a significant decrease in ADMA levels of ex-ELBW subjects compared to C, underlining a probable correlation with preterm birth and low birth weight. Taken together, these results may underlie the onset of early circulatory dysfunction predictive of increased cardiovascular risk.
PASS
pubmedQA
1
12632437
To investigate the association between primary systemic vasculitis (PSV) and environmental risk factors. Seventy-five PSV cases and 273 controls (220 nonvasculitis, 19 secondary vasculitis, and 34 asthma controls) were interviewed using a structured questionnaire. Factors investigated were social class, occupational an...
Are environmental factors important in primary systemic vasculitis?
Yes. A significant association between farming and PSV has been identified for the first time. Results also support previously reported associations with silica, solvents, and allergy.
PASS
pubmedQA
1
12630042
The long-term survival of patients with gastric cancer is governed by various factors, such as the clinical stage of the cancer, the patient's nutritional state, and the treatment and may be governed by the volume of intraperitoneal adipose tissue. The aim of this study is to clarify the relationship between the degree...
Does body mass index (BMI) influence morbidity and long-term survival in gastric cancer patients after gastrectomy?
Maybe. The body mass index is one of the prognostic factors of stage 2 and stage 3a gastric cancer. However, it does not appear to be useful for determining the prognosis of stage 1a, 1b, 3b, and 4a gastric cancers.
PASS
pubmedQA
1
25571931
Among patients with acute stroke symptoms, delay in hospital admission is the main obstacle for the use of thrombolytic therapy and other interventions associated with decreased mortality and disability. The primary aim of this study was to assess whether an elderly clinical population correctly endorsed the response t...
Do elderly patients call 911 when presented with clinical scenarios suggestive of acute stroke?
Maybe. These results suggest the need to provide interventions that are specifically designed to increase awareness of potential stroke signs and symptoms and appropriate subsequent clinical actions.
PASS
pubmedQA
1
22491528
To determine if composite measures based on process indicators are consistent with short-term outcome indicators in surgical colorectal cancer care. Longitudinal analysis of consistency between composite measures based on process indicators and outcome indicators for 85 Dutch hospitals. The Dutch Surgical Colorectal Au...
Combining process indicators to evaluate quality of care for surgical patients with colorectal cancer: are scores consistent with short-term outcome?
Maybe. For individual patients, a high score on the composite measures based on process indicators is not associated with better short-term outcome. However, at the hospital level, a good score on the composite measures based on process indicators was consistent with more favourable risk-adjusted short-term outcome rat...
PASS
pubmedQA
1
20605051
Reimbursement based on the total care of a patient during an acute episode of illness is believed to stimulate management and clinicians to reduce quality problems like waiting times and poor coordination of care delivery. Although many studies already show that this kind of case-mix based reimbursement leads to more e...
Does case-mix based reimbursement stimulate the development of process-oriented care delivery?
Yes. This study demonstrates that hospital management can stimulate the development of care programmes by the adoption of case-mix reimbursement within hospitals' budgeting processes. Future research is recommended to confirm this finding and to determine whether the establishment of care programmes will in time indeed...
PASS
pubmedQA
1
12377809
Dyschesia can be provoked by inappropriate defecation movements. The aim of this prospective study was to demonstrate dysfunction of the anal sphincter and/or the musculus (m.) puborectalis in patients with dyschesia using anorectal endosonography. Twenty consecutive patients with a medical history of dyschesia and a c...
Is anorectal endosonography valuable in dyschesia?
Yes. Linear anorectal endosonography demonstrated incomplete or even absent relaxation of the anal sphincter and the m. puborectalis during a defecation movement in the majority of our patients with dyschesia. This study highlights the value of this elegant ultrasonographic technique in the diagnosis of "pelvic floor d...
PASS
pubmedQA
1
23761381
Testosterone measurement by liquid chromatography tandem mass spectrometry (LC-MS/MS) is well accepted as the preferred technique for the analysis of testosterone. Variation is seen between assays and this may be due to differences in calibration as commercial calibrators for this assay are not readily available. We in...
Is calibration the cause of variation in liquid chromatography tandem mass spectrometry testosterone measurement?
No. The variation in results obtained could not be attributed to variations in calibrators. The differences in methodologies between laboratories must be the reason for this variation.
PASS
pubmedQA
1
15041506
Sources of reports about laparoscopic and percutaneous treatment of liver hydatid cysts are limited to just a few countries. To address the reason behind this, we carried out a survey of 30 surgeons in northern Jordan. A questionnaire was distributed to collect data regarding the surgical technique preferred by each su...
Is fear of anaphylactic shock discouraging surgeons from more widely adopting percutaneous and laparoscopic techniques in the treatment of liver hydatid cyst?
Yes. The seemingly exaggerated traditional fear of anaphylaxis seems to discourage surgeons from more widely adopting minimal access techniques for the treatment of hydatid cyst.
PASS
pubmedQA
1
23347337
To provide equality of cancer care to rural patients, Townsville Cancer Centre administers intensive chemotherapy regimens to rural patients with node-positive breast and metastatic colorectal cancers at the same doses as urban patients. Side-effects were usually managed by rural general practitioners locally.AIM: The ...
Is intensive chemotherapy safe for rural cancer patients?
Yes. It appears safe to administer intensive chemotherapy regimens at standard doses to rural patients without increased morbidity or mortality. Support for general practitioners through phone or videoconferencing may reduce the safety concerns.
PASS
pubmedQA
1
15369037
Regular inhalation of tobacco smoke, whether it be voluntary or not, may have profound negative effects on the body. Also intervertebral discs may be affected. The objective of the present study was to test the hypothesis that nurses' aides who were exposed to environmental tobacco smoke (ETS) at home during childhood ...
Do people who were passive smokers during childhood have increased risk of long-term work disability?
Yes. The study supports the hypothesis that nurses' aides who were exposed to ETS at home during childhood have an increased risk of long-term sickness absence.
PASS
pubmedQA
1
19615731
Epidemiologic findings support a positive association between asthma and obesity. Determine whether obesity or increasing level of body mass index (BMI) are associated with worse asthma control in an ethnically diverse urban population. Cross-sectional assessment of asthma control was performed in patients with asthma ...
Does higher body mass index contribute to worse asthma control in an urban population?
No. Using 4 validated asthma control questionnaires, we failed to find an association between obesity and asthma control in an urban population with asthma. Weight loss may not be an appropriate strategy to improve asthma control in this population.
PASS
pubmedQA
1
9347843
Because of the inflammatory nature of Crohn's disease, ileocolic resections are often difficult to perform, especially if an abscess, phlegmon, or recurrent disease at a previous ileocolic anastomosis is present. Our goal was to determine whether the above factors are contraindications to a successful laparoscopic-assi...
Laparoscopic-assisted ileocolic resections in patients with Crohn's disease: are abscesses, phlegmons, or recurrent disease contraindications?
No. The laparoscopic-assisted approach to Crohn's disease is feasible and safe with good outcomes. Co-morbid preoperative findings such as abscess, phlegmon, or recurrent disease at the previous ileocolic anastomosis are not contraindications to a successful laparoscopic-assisted ileocolic resection in select patients.
PASS
pubmedQA
1
20736672
To assess whether perspective-taking, which researchers in other fields have shown to induce empathy, improves patient satisfaction in encounters between student-clinicians and standardized patients (SPs). In three studies, randomly assigned students (N = 608) received either a perspective-taking instruction or a neutr...
Does perspective-taking increase patient satisfaction in medical encounters?
Maybe. Perspective-taking increased patient satisfaction in all three studies, across medical schools, clinical disciplines, and racially diverse students and SPs. Perspective-taking as a means for improving patient satisfaction deserves further exploration in clinical training and practice.
PASS
pubmedQA
1
17276801
The purpose of this study was to evaluate the value of elevated cardiac troponin I (cTnI) for prediction of complicated clinical course and in-hospital mortality in patients with confirmed acute pulmonary embolism (PE). This study was a retrospective chart review of patients diagnosed as having PE, in whom cTnI testing...
Can elevated troponin I levels predict complicated clinical course and inhospital mortality in patients with acute pulmonary embolism?
Yes. Our results indicate that elevated cTnI levels are associated with higher risk for inhospital mortality and complicated clinical course. Troponin I may play an important role for the risk assessment of patients with PE. The idea that an elevation in cTnI levels is a valuable parameter for the risk stratification o...
PASS
pubmedQA
1
10201555
Serum chloride level is routinely assayed in clinical laboratories in the management of patients with kidney disorders and with metabolic diseases. It is a biological parameter that is easily, precisely and relatively cheaply measured. The epidemiological features of serum chloride levels have not been studied before. ...
Is low serum chloride level a risk factor for cardiovascular mortality?
Yes. This s the first report from a population-based study to indicate that there is an association between serum chloride level and the incidence of total, CVD and non-CVD mortalities. The risk ratio for CVD mortality associated with a low serum chloride level was comparable to or higher than those observed for well-e...
PASS
pubmedQA
1
19237087
An unknown number of colorectal cancers could be due to missed adenomas during previous endoscopy. Data in the literature are sparse. A large cross-sectional study was done in a prospective database of all patients diagnosed with colorectal cancer. All consecutive endoscopies over a period of 15 years, in which colorec...
Are many colorectal cancers due to missed adenomas?
No. In normal daily practice, only a small number of clinically important adenomas are missed. The problem of missed adenomas probably is being exaggerated.
PASS
pubmedQA
1
26133538
Abdominal bloating is reported by a majority of irritable bowel syndrome (IBS) patients. Excess colonic fermentation may cause gaseous symptoms. Several foodstuffs contain oligosaccharides with an α-galactosidic linkage that is resistant to mammalian hydrolases. Assisted hydrolysis by exogenous α-galactosidase enzyme (...
Does oral α-galactosidase relieve irritable bowel symptoms?
No. We found no evidence to support the use of AG routinely in IBS patients. Improvement of clinical response at 4-week follow-up may suggest a long-term effect of unknown mechanism, but could also be attributed to non-responder drop out. Gastrointestinal (GI) side effects may be a coincidence in this study, but irrita...
PASS
pubmedQA
1
26516021
Evidence-based practice (EBP) is widely promoted, but does EBP produce better patient outcomes? We report a natural experiment when part of the internal medicine service in a hospital was reorganized in 2003 to form an EBP unit, the rest of the service remaining unchanged. The units attended similar patients until 2012...
Does evidence-based practice improve patient outcomes?
Yes. The EBP unit was associated with better patient outcomes and more efficient performance than achieved by the same physicians previously or by SP concurrently.
PASS
pubmedQA
1
27131771
The alterations of echocardiography and electrocardiogram (ECG) in patients received left atrial appendage LAA occlusion therapy are still unclear. The present study was to evaluate the influence of LAA occlusion device on echocardiography and ECG changes in patients with atrial fibrillation (AF). Seventy-three patient...
Does left atrial appendage (LAA) occlusion device alter the echocardiography and electrocardiogram parameters in patients with atrial fibrillation?
Yes. LAA occlusion device resulted in a slightly movement in QRS axis, reduced HR and increased the mean-mean QT interval duration. In addition, LA diameter and ARD seemed to be larger after device implantation.
PASS
pubmedQA
1
21342862
To evaluate the construct validity of the Turkish version of the EQ-5D in patients with acute coronary syndrome. The study was conducted as a cross-sectional study at the Trakya University Hospital between February and May 2008. All patients completed the Turkish version of the EQ-5D and MacNew heart-related quality of...
Is EQ-5D a valid quality of life instrument in patients with acute coronary syndrome?
Yes. The Turkish version of the EQ-5D-based utility score seems to be a valid instrument in the assessment of quality of life studies in patients with acute coronary syndrome.
PASS
pubmedQA
1
11438275
It is generally believed that positioning of the patient in a head-down tilt (Trendelenberg position) decreases the likelihood of a venous air embolism during liver resection. The physiological effect of variation in horizontal attitude on central and hepatic venous pressure was measured in 10 patients during liver sur...
Does patient position during liver surgery influence the risk of venous air embolism?
No. The effect on venous pressures caused by the change in patient positioning alone during liver surgery does not affect the risk of venous air embolism.
PASS
pubmedQA
1
28011794
Manual resuscitation devices for infants and newborns must be able to provide adequate ventilation in a safe and consistent manner across a wide range of patient sizes (0.5-10 kg) and differing clinical states. There are little comparative data assessing biomechanical performance of common infant manual resuscitation d...
Can Ambu self-inflating bag and Neopuff infant resuscitator provide adequate and safe manual inflations for infants up to 10 kg weight?
Maybe. The Ambu SIB was able to accurately deliver targeted pressures across all three models from preterm to infant. The Neopuff infant resuscitator was unable to deliver the targeted pressures in the infant model developing clinically significant levels of inadvertent PEEP which may pose risk during infant resuscitat...
PASS
pubmedQA
1
12690589
To compare the myoelectric onset of muscle fatigue in physically active trained young skiers with respect to elderly skiers and to test whether continuous training can counteract the selective loss of type II muscle fibers usually observed with aging. An observational, cross-sectional study of the myoelectric onset of ...
Can continuous physical training counteract aging effect on myoelectric fatigue?
Yes. It appears possible that aging skeletal muscles subjected to continuous exercise develop an adaptive response that counteracts the selective loss of type II muscle fibers usually observed in the muscles of elderly sedentary subjects. Our results suggest that physical activity could be considered in the elderly wit...
PASS
pubmedQA
1
9603166
Human immunodeficiency virus (HIV)-infected patients have generally been excluded from transplantation. Recent advances in the management and prognosis of these patients suggest that this policy should be reevaluated. To explore the current views of U.S. transplant centers toward transplanting asymptomatic HIV-infected...
Should all human immunodeficiency virus-infected patients with end-stage renal disease be excluded from transplantation?
No. The great majority of U.S. renal transplant centers will not transplant kidneys to HIV-infected patients with end-stage renal disease, even if their infection is asymptomatic. However, advances in the management of HIV infection and a review of relevant ethical issues suggest that this approach should be reconsider...
PASS
pubmedQA
1
16735905
To investigate polysomnographic and anthropomorphic factors predicting need of high optimal continuous positive airway pressure (CPAP). Retrospective data analysis. Three hundred fifty-three consecutive obstructive sleep apnea (OSA) patients who had a successful manual CPAP titration in our sleep disorders unit. The me...
Does the severity of obstructive sleep apnea predict patients requiring high continuous positive airway pressure?
Maybe. Severe OSA patients are much more likely to need high CPAP levels. However, because of the low positive predictive value (only 28.6%), the clinical value of such information is limited. ESS and MSLT did not increase the predictive value for the need for high CPAP.
PASS
pubmedQA
1
10834864
Avascular necrosis of bone (AVN) is a well known complication in patients with systemic lupus erythematosus (SLE). To investigate the role of antiphospholipid antibody status (IgM and IgG anticardiolipin antibodies and lupus anticoagulant) with adjustment for corticosteroid use as risk factors for the development of AV...
Risk factors for avascular necrosis of bone in patients with systemic lupus erythematosus: is there a role for antiphospholipid antibodies?
No. Incorporating an adjustment for corticosteroid use we were unable to show a link between the presence of aPL and the development of AVN in patients with SLE.
PASS
pubmedQA
1
24671913
SYNTAX score (SxS) has been demonstrated to predict long-term outcomes in stable patients with coronary artery disease. But its prognostic value for patients with acute coronary syndrome remains unknown.AIM: To evaluate whether SxS could predict in-hospital outcomes for patients admitted with ST elevation myocardial in...
Does SYNTAX score predict in-hospital outcomes in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention?
Yes. SxS is a useful tool that can predict in-hospital outcomes of patients with STEMI undergoing pPCI.
PASS
pubmedQA
1
24614851
The purpose of this study was to clarify the prognostic factors for cervical spondylotic amyotrophy (CSA). The authors retrospectively reviewed the medical records of 47 consecutive patients with CSA in whom the presence/absence of the pyramidal tract sign was noted. We analyzed whether the age, sex, presence of diabet...
Prognostic factors for cervical spondylotic amyotrophy: are signs of spinal cord involvement associated with the neurological prognosis?
Yes. The presence of a high signal intensity change on T2-weighted MRI and the pyramidal tract sign can be used as prognostic factors for patients with CSA.
PASS
pubmedQA
1
12855939
longitudinal descriptive study. 2 large nursing homes in Turin, Italy. 418 dependent elderly (83 males, 335 females, mean age 83.7+/-8.5 y, range 55-102) living in the nursing homes. the prevalence of peripheral arterial disease (PAD) was evaluated using a Doppler Ultrasound measurement of AAI (Ankle/Arm blood pressure...
Is ankle/arm pressure predictive for cardiovascular mortality in older patients living in nursing homes?
No. The prevalence of PAD is high in nursing home residents. AAI is not predictive for IHD mortality in this population. In very frail elderly traditional risk factors and PAD are less important predictors of death compared to poor functional status, nutritional factors and previous cardiovascular disease.
PASS
pubmedQA
1
18802997
Assessing the clinical course of inflammatory bowel disease (IBD) patients consists of periodical clinical evaluations and laboratory tests. We aimed to assess the role of calprotectin tests in predicting clinical relapse in IBD patients. Ninety-seven patients with ulcerative colitis (UC) and 65 with Crohn's disease (C...
Can calprotectin predict relapse risk in inflammatory bowel disease?
Maybe. Measuring calprotectin may help to identify UC and colonic CD patients at higher risk of clinical relapse.
PASS
pubmedQA
1
15774570
The use of the private sector for health care is increasing, but it is unclear whether this will reduce demand on the NHS. The aim of this study was to examine the relationship between private and NHS outpatient referral rates accounting for their association with deprivation. This is a prospective survey of general pr...
Does increased use of private health care reduce the demand for NHS care?
No. Increased private health care activity does not reduce the demand for NHS care: NHS and private referral rates were positively associated with each other after adjusting for age, deprivation and practice.
PASS
pubmedQA
1
8916748
To assess the risk of death associated with work based and non-work based measures of socioeconomic status before and after retirement age. Follow up study of mortality in relation to employment grade and car ownership over 25 years. The first Whitehall study. 18,133 male civil servants aged 40-69 years who attended a ...
Do socioeconomic differences in mortality persist after retirement?
Yes. Socioeconomic differences in mortality persist beyond retirement age and in magnitude increase with age. Social differentials in mortality based on an occupational status measure seem to decrease to a greater degree after retirement than those based on a non-work measure. This suggests that alongside other socioec...
PASS
pubmedQA
1
18399830
To evaluate whether robotically assisted laparoscopic prostatectomy (RALP) is less invasive than radical retropubic prostatectomy (RRP), as experimental studies suggest that the acute phase reaction is proportional to surgery-induced tissue damage. Between May and November 2006, all patients undergoing RRP or RALP in o...
Is robotically assisted laparoscopic radical prostatectomy less invasive than retropubic radical prostatectomy?
Yes. This study showed for the first time that RALP induces lower tissue trauma than RRP.
PASS
pubmedQA
1
27928673
The mode of delivery depends on multiple parameters. After assisted reproductive technology (ART), previous studies have shown elevated C-section rates but few studies differentiated between elective and emergency operations and different protocols of cryopreservation. Because these studies did not use multiparity as e...
Do ART patients face higher C-section rates during their stage of delivery?
Yes. Patients after ART treatment suffer from higher C-section rates during their stage of delivery.
PASS
pubmedQA
1
21739621
To examine longitudinal patterns in body mass index (BMI) over 14 years and its association with knee pain in the Chingford Study. We studied a total of 594 women with BMI data from clinic visits at years (Y) 1, 5, 10, and 15. Knee pain at Y15 was assessed by questionnaire. Associations between BMI over 14 years and kn...
Does obesity predict knee pain over fourteen years in women, independently of radiographic changes?
Yes. Over 14 years, a higher BMI predicts knee pain at Y15 in women, independently of radiographic knee OA. When adjusted, the association was significant in bilateral, not unilateral, knee pain, suggesting alternative pathologic mechanisms may exist. The longitudinal effect of BMI on knee pain at Y15 is equally import...
PASS
pubmedQA
1
25487603
The aim of this study was to describe the evolution and epidemiologic characteristics of shigellosis patients over a 25 year period in a large city. Shigellosis is a notifiable disease in Spain since 1988. Cases are analyzed in Barcelona residents included in the registry between 1988-2012. A descriptive analysis by se...
Analysis of the epidemiological pattern of Shigellosis in Barcelona between 1988 and 2012: Is it an emerging sexually transmitted infection?
Yes. An increased trend was detected in men who had no history of food poisoning or travel to endemic areas. This increase points to a change in the pattern of shigellosis, becoming predominantly male and its main mechanism probably by sexual transmission.
PASS
pubmedQA
1
11481172
The authors sought to determine whether the manic/mixed episode distinction in patients with bipolar disorder runs true over time. Over an 11-year period, the observed distribution of manic and mixed episodes (N=1,224) for patients with three or more entries in the management information system of a community mental he...
Does the manic/mixed episode distinction in bipolar disorder patients run true over time?
Yes. These data suggest a pattern of diagnostic stability over time for manic and mixed episodes in patients with bipolar disorder. Careful prospective studies of this issue are needed.
PASS
pubmedQA
1
23506394
Arterial calcification is a significant cardiovascular risk factor in hemodialysis patients. A series of factors are involved in the process of arterial calcification; however, the relationship between malnutrition and arterial calcification is still unclear. 68 hemodialysis patients were enrolled in this study. Nutrit...
Malnutrition, a new inducer for arterial calcification in hemodialysis patients?
Yes. Malnutrition is prevalent in hemodialysis patients and is associated with arterial calcification and the expressions of BMP2 and MGP in calcified radial arteries. Malnutrition may be a new inducer candidate for arterial calcification in hemodialysis patients.
PASS
pubmedQA
1
26175531
It is unclear whether intravenous glycoprotein IIb/IIIa inhibitors or ischemic time might modify any clinical benefits observed with aspiration thrombectomy before primary percutaneous coronary intervention (PCI) in patients with ST-segment-elevation myocardial infarction. Electronic databases were searched for trials ...
Is Aspiration Thrombectomy Beneficial in Patients Undergoing Primary Percutaneous Coronary Intervention?
No. Aspiration thrombectomy before primary PCI is not associated with any benefit on clinical end points and might increase the risk of stroke. Concomitant administration of intravenous glycoprotein IIb/IIIa inhibitors and ischemic time did not seem to influence any potential benefits observed with aspiration thrombect...
PASS
pubmedQA
1
24799031
The objective was to evaluate the efficacy of diffusion-weighted imaging (DWI) in predicting the development of vascularization in hypovascular hepatocellular lesions (HHLs). Forty-two HHLs that were diagnosed by computed tomographic (CT) arteriography were evaluated retrospectively. The lesion on DWI was classified as...
Is diffusion-weighted imaging a significant indicator of the development of vascularization in hypovascular hepatocellular lesions?
No. The signal intensity on DWI showed no significant difference in the development of vascularization.
PASS
pubmedQA
1
22349635
Treatment of elderly cancer patients has gained importance. One question regarding the treatment of metastatic spinal cord compression (MSCC) is whether elderly patients benefit from surgery in addition to radiotherapy? In attempting to answer this question, we performed a matched-pair analysis comparing surgery follow...
Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?
No. Elderly patients with MSCC did not benefit from surgery in addition to radiotherapy regarding functional outcome, local control of MSCC, or survival.
PASS
pubmedQA
1
24449622
This study aimed to show the relationship between serum paraoxonase 1 level and the epicardial fat tissue thickness. Two hundred and seven patients without any atherosclerotic disease history were included in this cross-sectional observational study. Correlation analysis was performed to determine the correlation betwe...
Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?
No. Serum PON 1 level is not correlated with the epicardial fat tissue thickness. But PON 1 level is lower in patients with epicardial fat tissue thickness 7 mm and over. Therefore, increased atherosclerosis progression can be found among patients with 7 mm and higher epicardial fat tissue thickness.
PASS
pubmedQA
1
15000338
To determine the cost of 46 commonly used investigations and therapies and to assess British Columbia family doctors' awareness of these costs. Mailed survey asking about costs of 23 investigations and 23 therapies relevant to family practice. A random sample of 600 doctors was asked to report their awareness of costs ...
Do family physicians know the costs of medical care?
No. Family doctors in British Columbia have little awareness of the costs of medical care.
PASS
pubmedQA
1
23455575
The so-called "globulomaxillary cyst", described as a fissural cyst, caused by entrapped epithelium between the nasal and maxillary process, is no longer considered for its own entity. Nevertheless, cystic lesions, which correspond to the previous image of globulomaxillary cysts, do still occur in daily practice. This ...
Globulomaxillary cysts--do they really exist?
No. According to the results of our study and the data from the international literature, the entity globulomaxillary cyst is no longer justified.
PASS
pubmedQA
1
17578985
In this prospective, randomized, double-blind study, we compared the tibial and the peroneal evoked motor response with regard to efficacy of sciatic nerve block using the parasacral approach. Twenty-six ASA I-III patients scheduled for elective lower limb surgery were randomized to receive a parasacral sciatic block, ...
Parasacral sciatic nerve block: does the elicited motor response predict the success rate?
Maybe. Eliciting a tibial motor response predicts a higher success rate than eliciting a peroneal motor response with parasacral sciatic nerve block.
PASS
pubmedQA
1
22849512
The aim of this study is to explore whether availability of sports facilities, parks, and neighbourhood social capital (NSC) and their interaction are associated with leisure time sports participation among Dutch adolescents. Cross-sectional analyses were conducted on complete data from the last wave of the YouRAction ...
Are neighbourhood social capital and availability of sports facilities related to sports participation among Dutch adolescents?
Maybe. The results of this study indicate that leisure time sports participation is associated with levels of NSC, but not with availability of parks or sports facilities. In addition, NSC and availability of parks in the zip code area interacted in such a way that leisure time sports participation is most likely among...
PASS
pubmedQA
1
19578820
Opioid-dependent patients often have co-occurring chronic illnesses requiring medications that interact with methadone. Methadone maintenance treatment (MMT) is typically provided separately from medical care. Hence, coordination of medical care and substance use treatment is important to preserve patient safety. To id...
Are opioid dependence and methadone maintenance treatment (MMT) documented in the medical record?
Maybe. Among patients receiving MMT and medical care at different sites, documentation of opioid dependence and MMT in the medical record occurs for the majority, but is missing in a substantial number of patients. Most of these patients are prescribed medications that potentially interact with methadone. This study hi...
PASS
pubmedQA
1
14627582
The purpose of our study was to determine the effectiveness, clinical impact, and feasibility of double reading barium enemas. Independent double readings of 1,003 consecutive barium enemas (822 double- and 181 single-contrast examinations) were prospectively performed. From this pool of 1,003 examinations, 994 were in...
Double reading of barium enemas: is it necessary?
No. Although feasible, double reading of barium enemas does not improve sensitivity for detection of polyps and produces a higher false-positive rate.
PASS
pubmedQA
1
23736032
A multidisciplinary team (MDT) approach to breast cancer management is the gold standard. The aim is to evaluate MDT decision making in a modern breast unit. All referrals to the breast MDT where breast cancer was diagnosed from 1 July 2009 to 30 June 2011 were included. Multidisciplinary team decisions were compared w...
Multidisciplinary decisions in breast cancer: does the patient receive what the team has recommended?
Yes. The vast majority of MDT decisions are implemented. Management alteration was most often due to patient choice or additional information available after the MDT. A minority of management alterations were 'unjustifiable' and the authors recommend that any patient whose treatment is subsequently changed should have ...
PASS
pubmedQA
1
22303473
Family caregivers of dementia patients are at increased risk of developing depression or anxiety. A multi-component program designed to mobilize support of family networks demonstrated effectiveness in decreasing depressive symptoms in caregivers. However, the impact of an intervention consisting solely of family meeti...
Does a family meetings intervention prevent depression and anxiety in family caregivers of dementia patients?
No. This study did not demonstrate preventive effects of family meetings on the mental health of family caregivers. Further research should determine whether this intervention might be more beneficial if provided in a more concentrated dose, when applied for therapeutic purposes or targeted towards subgroups of caregiv...
PASS
pubmedQA
1
17890090
The aim of this study was to determine whether bone scans (BS) can be avoided if pelvis was included in CT thorax and abdomen to detect bony metastases from breast cancer. Results of 77 pairs of CT (thorax, abdomen, and pelvis) and BS in newly diagnosed patients with metastatic breast cancer (MBC) were compared prospec...
Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer?
Yes. Our findings suggest routine BS of patients presenting with MBC is not required if CT (thorax, abdomen, and pelvis) is performed.
PASS
pubmedQA
1
17274051
The aim of the study was to evaluate the outcomes and patterns of failure in patients with metastatic carcinoma to cervical lymph nodes from an unknown head and neck primary origin, who were treated curatively with radiotherapy, with or without neck dissection. The study included 61 patients referred to the McGill Univ...
Metastatic carcinoma to the cervical nodes from an unknown head and neck primary site: Is there a need for neck dissection?
No. In our experience, definitive radiotherapy to the neck and the potential mucosal sites, whether preceded by neck dissection or not, is effective to achieve a good local control rate in the unknown primary cancer of the head and neck. The indication for neck dissection, in particular for early nodal stage, is contro...
PASS
pubmedQA
1
18801797
Fruit and vegetables are protective of a number of chronic diseases; however, their intakes have been shown to vary by socioeconomic position (SEP). Household and food shopping environmental factors are thought to contribute to these differences. To determine whether household and food shopping environmental factors ar...
Household and food shopping environments: do they play a role in socioeconomic inequalities in fruit and vegetable consumption?
No. Improving access to FV in the household and food shopping environments will only make a small contribution to improving population consumption levels, and may only have a limited effect in reducing socioeconomic inequalities in their consumption.
PASS
pubmedQA
1
25891436
Previous studies have reported that the total bilirubin (TB) level is associated with coronary artery disease, heart failure and atrial fibrillation. These heart diseases can produce cardiogenic cerebral embolism and cause cardioembolic stroke. However, whether the serum TB could be a biomarker to differentiate cardioe...
Is serum total bilirubin useful to differentiate cardioembolic stroke from other stroke subtypes?
Yes. Serum TB level was independently associated with cardioembolic stroke. The combination of clinical data and serum TB may be a feasible strategy to diagnose cardioembolic stroke in the acute phase.
PASS
pubmedQA
1
17682349
To identify gender differences in delay time and the reasons why African Americans delay in seeking medical care for symptoms of acute myocardial infarction (AMI). Cross-sectional. Five hospitals in the San Francisco and East Bay areas. Sixty-one African American men and women diagnosed with an AMI. Prehospital delay t...
Are there gender differences in the reasons why African Americans delay in seeking medical help for symptoms of an acute myocardial infarction?
Yes. Women compared to men often delay seeking treatment for an AMI, which further increases their risks. Our findings suggest specific characteristics that can serve as a profile to those African Americans most likely to delay seeking treatment for AMI.
PASS
pubmedQA
1
End of preview. Expand in Data Studio

PubMedQA subset of HaluBench

Dataset

This dataset contains the PubMedQA subset of HaluBench, created by Patronus AI and available from PatronusAI/HaluBench

The dataset was originally published in the paper PubMedQA: A Dataset for Biomedical Research Question Answering

The PubMedQA subset of HaluBench contains additional perturbations to the original dataset to generate hallucinated answers that appear plausible but are not faithful to the context as described in Lynx: An Open Source Hallucination Evaluation Model

Preprocessing

We mapped the original hallucination labels as follows:

  • "PASS" or no hallucination to 1
  • "FAIL" or hallucination to 0

Evaluation criteria and rubric

We aligned our evaluation criteria and rubric with the one used in the Lynx paper. These criteria and rubrics are used by the LM judge to produce the score for each response.

EVALUATION_CRITERIA =  "Evaluate whether the information provided in the answer is factually accurate and directly supported by the context given in the document, without any fabricated or hallucinated details."

RUBRIC = [
    { 
        "score": 0, 
        "description": "The answer is not supported by the document. It contains inaccuracies, fabrications, or details that are not present in the document."
    },
    { 
        "score": 1, 
        "description": "The answer is fully supported by the document. It is factually accurate and all details are directly derived from the document."
    } 

]  
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