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id string | label int64 | article dict |
|---|---|---|
10709885 | 1 | {
"id": "10709885",
"text": "Coeliac disease has emerged as a public health problem. The aim of the present study was to analyse trends in the occurrence of symptomatic coeliac disease in Swedish children from 1973 to 1997, and to explore any temporal relationship to changes in infant dietary patterns. We establish... |
11080708 | 1 | {
"id": "11080708",
"text": "BACKGROUND:\nEvents occurring during fetal life may affect the development of the immune and respiratory systems and increase the risk of asthma and allergic diseases.\n\nOBJECTIVES:\nWe sought to elaborate the relations between the occurrence of pregnancy complications and other pregna... |
11312420 | 1 | {
"id": "11312420",
"text": "BACKGROUND:\nOral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is a highly effective therapy for psoriasis and many other skin conditions. It is carcinogenic. Previously we reported an increased risk of melanoma that first emerged 15 years after first treatment.\n\nOBJECTIV... |
11522737 | 1 | {
"id": "11522737",
"text": "BACKGROUND & AIMS:\nResults concerning an association between cholecystectomy and right-sided colon cancer are inconsistent. Little is known about the relation between cholecystectomy and small bowel cancer. Therefore, we evaluated cholecystectomy and risk of bowel cancer.\n\nMETHODS:\n... |
11976167 | 1 | {
"id": "11976167",
"text": "BACKGROUND:\nCeliac disease, or permanent gluten-sensitive enteropathy, is an immunologic disease strictly dependent on exposure to wheat gluten or related proteins in rye and barley.\n\nOBJECTIVE:\nThe aim of this study was to explore whether breast-feeding and the mode of introducing ... |
12093765 | 1 | {
"id": "12093765",
"text": "BACKGROUND:\nInterleukin (IL)-18 plays a central role in orchestrating the cytokine cascade and accelerates atherosclerosis and plaque vulnerability in animal models. However, epidemiological data evaluating the role of IL-18 levels in atherosclerosis are lacking.\n\nMETHODS AND RESULTS... |
14519706 | 1 | {
"id": "14519706",
"text": "CONTEXT:\nDietary factors modifying type 1 diabetes mellitus (DM) risk have been proposed, but little is known if they trigger the islet autoimmunity that precedes clinical disease.\n\nOBJECTIVE:\nTo determine whether breastfeeding duration, food supplementation, or age at introduction ... |
15898094 | 1 | {
"id": "15898094",
"text": "BACKGROUND:\nExposure to occupational hazards among firefighters may lead to increased mortality from cancer, lung, or heart disease.\n\nMETHODS:\nAge- and gender-adjusted mortality rates of 34,796 male and 2,017 female Florida professional firefighters between 1972 and 1999 were compar... |
16364180 | 0 | {
"id": "16364180",
"text": "Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis (CRS) differential diagnosis. However, the classification and mechanisms of different CRS phenotypes remains problematic."
} |
16434451 | 1 | {
"id": "16434451",
"text": "CONTEXT:\nPolycystic ovary syndrome (PCOS) is associated with menstrual and reproductive abnormalities, insulin resistance, and obesity.\n\nOBJECTIVE:\nThe objective of this study was to determine the prevalence of diagnosed PCOS and its association with cardiovascular risk factors.\n\n... |
16495934 | 1 | {
"id": "16495934",
"text": "We directly compared risk factors between 214 histologically confirmed melanomas (CMM), 215 basal-cell carcinomas (BCC) and 139 squamous-cell carcinomas (SCC) in a multiple case-case-control study with 349 controls from patients without dermatological disease admitted to the same hospit... |
16845665 | 1 | {
"id": "16845665",
"text": "BACKGROUND:\nThe familial risk of bladder cancer (BC) is not well understood and, to date, little attention has been paid to the joint effect of smoking and family history in modifying the risk of BC. The authors investigated the role of family history in association with the risk of BC... |
16864817 | 1 | {
"id": "16864817",
"text": "OBJECTIVE:\nTo assess the influence of the body mass index (BMI) on the prevalence and severity of chronic daily headache (CDH) and its most frequent subtypes, transformed migraine (TM) and chronic tension-type headache (CTTH).\n\nMETHODS:\nThe authors gathered information on headache, ... |
17040332 | 1 | {
"id": "17040332",
"text": "Review of epidemiological and clinical studies suggests that sleep disorders are disproportionately observed in specific headache diagnoses (eg, migraine, tension-type, cluster) and other nonspecific headache patterns (ie, chronic daily headache, \"awakening\" or morning headache). Inte... |
17164760 | 1 | {
"id": "17164760",
"text": "In a prospective cohort study, a close to two-fold elevated risk of bladder cancer was found among men reporting a history of gonorrhoea (relative risk=1.92, 95% CI=1.10-3.33). Our finding warrants further examination of the role of gonorrhoea in bladder carcinogenesis."
} |
17311987 | 0 | {
"id": "17311987",
"text": "Perforin is a cytolytic protein expressed mainly in activated cytotoxic lymphocytes and natural killer cells. Inherited perforin mutations account for 20% to 40% of familial hemophagocytic lymphohistiocytosis, a fatal disease of early childhood characterized by the absence of functional... |
17427485 | 0 | {
"id": "17427485",
"text": "Clinically silent adrenal masses (incidentaloma) are incidentally discovered lesions when noninvasive imaging methods (ultrasonography--USG, computer tomography--CT, magnetic resonance imaging--MRI) are performed for the reason other than known or suspected adrenal disease. Most of stud... |
17634245 | 1 | {
"id": "17634245",
"text": "OBJECTIVES:\nAir pollution has been associated with an increased risk for lung cancer. We examined whether long-term air pollution is associated with bladder cancer risk.\n\nMETHODS:\nInformation from a case-control study in Spain that included 1219 incident cases and 1271 hospital cont... |
17646581 | 1 | {
"id": "17646581",
"text": "BACKGROUND:\nConsumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals.\n\nMETHODS AND RESULTS:\nWe related the incidence of metabolic syndrome and its components to soft drink cons... |
17671226 | 1 | {
"id": "17671226",
"text": "Cigarette smoking is a major risk factor for bladder cancer and a prominent point source of 4-aminobiphenyl (4-ABP), a recognized human bladder carcinogen. 4-ABP-hemoglobin (Hb) adducts are established biomarkers of 4-ABP exposure in humans. The role of environmental tobacco smoke (ETS)... |
17684133 | 1 | {
"id": "17684133",
"text": "The relationship between family history of cancer in first-degree relatives and risk of bladder cancer was examined in the Spanish Bladder Cancer Study. Information on family history of cancer was obtained for 1,158 newly diagnosed bladder cancer cases and 1,244 controls included in 18 ... |
17891891 | 1 | {
"id": "17891891",
"text": "Using the fixed-effect model, the author quantitatively estimated the risks of cancers of the colon, bladder, kidneys, and brain as well as non-Hodgkin's lymphoma and leukemia among firefighters. The risk of these six cancers was not markedly elevated when cohort mortality studies were ... |
17932376 | 1 | {
"id": "17932376",
"text": "RATIONALE:\nRisk factors for asthma among farm women are understudied.\n\nOBJECTIVES:\nWe evaluated pesticide and other occupational exposures as risk factors for adult-onset asthma.\n\nMETHODS:\nStudying 25,814 farm women in the Agricultural Health Study, we used self-reported history ... |
18311140 | 1 | {
"id": "18311140",
"text": "Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in an additional 1,643 cases and 3,406 controls. Through joint analysi... |
1833349 | 1 | {
"id": "1833349",
"text": "Case-control studies of Alzheimer's disease were re-analysed to examine the association of Alzheimer's disease with family history in first degree relatives of dementia, Down's syndrome and Parkinson's disease. Overall, the relative risk of Alzheimer's disease for those with at least one... |
18591432 | 1 | {
"id": "18591432",
"text": "BACKGROUND:\nPrediction of coronary heart disease (CHD) and cerebrovascular disease (CeVD) can aid healthcare providers and prevention programs. Previous reports have focused on traditional cardiovascular risk factors; less information has been available on the role of overweight and ob... |
19240061 | 1 | {
"id": "19240061",
"text": "OBJECTIVE:\nOur previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more... |
19244173 | 1 | {
"id": "19244173",
"text": "BACKGROUND:\nWith the exception of breast cancer, little is known about the effect of moderate intakes of alcohol, or of particular types of alcohol, on cancer risk in women.\n\nMETHODS:\nA total of 1,280,296 middle-aged women in the United Kingdom enrolled in the Million Women Study we... |
19454285 | 1 | {
"id": "19454285",
"text": "BACKGROUND & AIMS:\nCeliac disease (CD) is a common chronic disorder of the small intestine, resulting from aberrant cellular responses to gluten peptides, and often remains undiagnosed. It is a complex genetic disorder, although 95% of the patients carry the risk heterodimer human leuk... |
19500688 | 1 | {
"id": "19500688",
"text": "BACKGROUND & AIMS:\nSusceptibility to celiac disease (CD) is related to HLA-DQ2 and DQ8 alleles and the heterodimers they encode. The objective of this study was to stratify risk for CD on the basis of HLA-DQ genotype.\n\nMETHODS:\nDNA from 10,191 subjects who are at risk for CD was ana... |
19515369 | 0 | {
"id": "19515369",
"text": "Familial LCAT deficiency (FLD) is a disease characterized by a defect in the enzyme lecithin:cholesterol acyltransferase (LCAT) resulting in low HDL-C, premature corneal opacities, anemia as well as proteinuria and renal failure. We have identified the first French Canadian kindred with... |
19789839 | 1 | {
"id": "19789839",
"text": "Although the risk for most cancers appears to be relatively low in patients with Parkinson's disease (PD), skin cancers and melanomas occur more frequently in the PD population as compared to controls. This article summarizes the findings of cohort studies on skin cancer in Parkinson's ... |
20212233 | 1 | {
"id": "20212233",
"text": "OBJECTIVE:\nTo evaluate the possible association of Parkinson disease (PD) and melanoma in North America.\n\nDESIGN, SETTING, AND PATIENTS:\nThirty-one centers enrolled patients with idiopathic PD. At visit 1, a neurologist obtained a medical history. At visit 2, a dermatologist recorde... |
20231496 | 1 | {
"id": "20231496",
"text": "OBJECTIVE:\nTo quantify the risk of subsequent primary cancers among patients with primary cutaneous malignant melanoma.\n\nDESIGN:\nPopulation-based registry study.\n\nSETTING:\nWe evaluated data from 9 cancer registries of the Surveillance, Epidemiology, and End Results program from 1... |
20548022 | 1 | {
"id": "20548022",
"text": "We previously investigated bladder cancer risk in a cohort of dyestuff workers who were heavily exposed to aromatic amines from 1922 through 1972. We updated the follow-up by 14 years (through 2003) for 590 exposed workers to include more than 30 years of follow-up since last exposure t... |
20798970 | 1 | {
"id": "20798970",
"text": "Patients with longstanding extensive colitis, both ulcerative colitis and Crohn's colitis, have an increased risk of developing colorectal cancer. Because of this risk, colonoscopic surveillance for neoplasia is recommended by most authorities. Although there has been no randomised cont... |
21447005 | 0 | {
"id": "21447005",
"text": "Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis. It is characterized by non-malignant lymphoproliferation autoimmunity mostly directed toward blood cells and increased risk of lymphoma. Majority of patients with ALPS harbor heterozygous germline mu... |
22294430 | 1 | {
"id": "22294430",
"text": "Evidence concerning the role of Helicobacter pylori infection in the development of colorectal cancer remains controversial. The authors assessed the association of H. pylori seroprevalence with risk of colorectal cancer in a large population-based case-control study from Germany in 200... |
22833605 | 1 | {
"id": "22833605",
"text": "OBJECTIVE:\nTo estimate the burden of melanoma resulting from sunbed use in western Europe.\n\nDESIGN:\nSystematic review and meta-analysis.\n\nDATA SOURCES:\nPubMed, ISI Web of Science (Science Citation Index Expanded), Embase, Pascal, Cochrane Library, LILACS, and MedCarib, along with... |
22905651 | 1 | {
"id": "22905651",
"text": "BACKGROUND:\nPREVENTCD, Prevent Coeliac Disease, is an international project investigating the hypothesis of possible induction of tolerance to gluten in genetically predisposed children through introducing small quantities of gluten during the period of breastfeeding.\n\nAIM:\nTo summa... |
23155333 | 1 | {
"id": "23155333",
"text": "Celiac disease (CD) is one of the most common diseases, resulting from both environmental (gluten) and genetic factors [human leukocyte antigen (HLA) and non-HLA genes]. The prevalence of CD has been estimated to approximate 0.5%-1% in different parts of the world. However, the populati... |
23204143 | 1 | {
"id": "23204143",
"text": "A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer's disease. This study investigated the frequency and severity of atherosclerotic plaques in the circle of Willis in Alzheimer's disease and multiple other neurodegenerative diseases. Semi-... |
23531950 | 0 | {
"id": "23531950",
"text": "Alveolar soft-part sarcoma (ASPS) is a translocation-associated sarcoma that occurs most commonly in the lower extremities and rarely in orbit. Only 34 orbital cases have been reported in the literature, and it is often misdiagnosed due to its rare occurrence and nonspecific clinical fi... |
23569324 | 1 | {
"id": "23569324",
"text": "PURPOSE:\nSite-specific risk of colorectal cancer (CRC) among survivors of endometrial cancer (EC) is not known. The objective of the present study was to assess the risk of CRC (overall and subsite specific) among EC survivors.\n\nMETHODS:\nA historical cohort study was performed by li... |
23620537 | 1 | {
"id": "23620537",
"text": "BACKGROUND:\nHyperuricemia is known to be a risk factor for incident type 2 diabetes mellitus, but the absolute magnitude of the association is not known. We aimed to evaluate the strength of association between hyperuricemia and the risk of developing diabetes among the US veterans wit... |
24101761 | 1 | {
"id": "24101761",
"text": "OBJECTIVES:\nTiming of gluten introduction has been associated with the risk of celiac disease (CD) in children, but the optimal time window is unknown. We aimed to study the effect of age of gluten introduction on the risk of CD, adjusting for continued breastfeeding.\n\nMETHODS:\nIn T... |
24164287 | 1 | {
"id": "24164287",
"text": "BACKGROUND:\nRecent studies reported increased risks for the development of asthma in children after prenatal exposure to acid-suppressive drugs. As a result of common pathogenesis, associations could also be present for other allergic diseases.\n\nMETHODS:\nUsing the prescription datab... |
24190118 | 1 | {
"id": "24190118",
"text": "PURPOSE:\nSteroid hormones, particularly androgens, play a major role in prostatic carcinogenesis. Personal history of severe acne, a surrogate for higher androgen activity, has been associated with an increased risk of prostate cancer (PCa), and one recent study indicated that severe t... |
24444654 | 1 | {
"id": "24444654",
"text": "We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks through 70 years of age of 7.2% for male carriers of monoallelic mutations (95% confidence interval [CI], 4.6%-11.3%) a... |
24876226 | 1 | {
"id": "24876226",
"text": "BACKGROUND:\nFew prospective studies have examined the relationship between sun exposure, other potential risk factors, and risk of different skin cancers [including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma] simultaneously.\n\nMETHODS:\nWe evaluated the as... |
24881994 | 1 | {
"id": "24881994",
"text": "BACKGROUND:\nThe associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared. In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascul... |
25104173 | 1 | {
"id": "25104173",
"text": "BACKGROUND:\nPosttraumatic stress disorder (PTSD) is associated with endocrine and immune abnormalities that could increase risk for autoimmune disorders. However, little is known about the risk for autoimmune disorders among individuals with PTSD.\n\nMETHODS:\nWe conducted a retrospect... |
25208536 | 1 | {
"id": "25208536",
"text": "OBJECTIVES:\nTo investigate the relation between the risk of Alzheimer's disease and exposure to benzodiazepines started at least five years before, considering both the dose-response relation and prodromes (anxiety, depression, insomnia) possibly linked with treatment.\n\nDESIGN:\nCase... |
25422909 | 1 | {
"id": "25422909",
"text": "BACKGROUND:\nAlcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.\n\nMETHODS:\nWe investigated the effect of alcohol on 23 cancer types through a meta-analytic... |
25623697 | 1 | {
"id": "25623697",
"text": "OBJECTIVE:\nTo investigate the association of cannabis use and tobacco smoking on the incidence of bladder cancer within the California Men's Health Study cohort.\n\nMETHODS:\nWe evaluated the records of 84,170 participants in a multiethnic cohort of men aged 45-69 years. Information on... |
25671687 | 1 | {
"id": "25671687",
"text": "IMPORTANCE:\nThe risk of next melanoma in patients with 2 or more previous melanomas stratified by familial and sporadic cases separately has not yet been reported, although a few population-based studies have assessed the risk of second melanoma.\n\nOBJECTIVE:\nTo assess the risk of ne... |
26103029 | 1 | {
"id": "26103029",
"text": "IMPORTANCE:\nThe target for the oral erectile dysfunction drugs, phosphodiesterase type 5 (PDE5) inhibitors, is part of a pathway implicated in the development of malignant melanoma. An increased risk of melanoma in sildenafil users was recently reported.\n\nOBJECTIVE:\nTo examine the a... |
26124488 | 1 | {
"id": "26124488",
"text": "PURPOSE:\nCitrus products are widely consumed foods that are rich in psoralens and furocoumarins, a group of naturally occurring chemicals with potential photocarcinogenic properties. We prospectively evaluated the risk of cutaneous malignant melanoma associated with citrus consumption.... |
26416192 | 1 | {
"id": "26416192",
"text": "OBJECTIVES:\nFirst-degree relatives (FDRs) of patients with celiac disease (CD) are at high risk for CD and prevalence among them varies from 1.6 to 38%. The risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, or daughter of index patient with CD is not know... |
26426533 | 1 | {
"id": "26426533",
"text": "BACKGROUND:\nThe risk of periodontitis (PD) is increased in the patient group of rheumatoid arthritis (RA). RA and PD also shared some pathological mechanism. The aim of this study is to investigate the risk of RA associated with PD exposure.\n\nMETHODS AND FINDINGS:\nThis study identif... |
26453630 | 1 | {
"id": "26453630",
"text": "There are conflicting data regarding the magnitude and determinants of chronic obstructive pulmonary disease (COPD) risk in farmers.In a cross-sectional study of 917 nonfarming working controls and 3787 farmers aged 40-75 years, we assessed respiratory symptoms, tobacco exposure, job hi... |
26541532 | 1 | {
"id": "26541532",
"text": "Recent studies suggest that males with chronic obstructive pulmonary disease (COPD) have more emphysema than females. It is not known if these differences persist across degrees of COPD severity. Our aim was to identify sex-specific differences in quantitative emphysema within COPD subg... |
26586037 | 1 | {
"id": "26586037",
"text": "BACKGROUND:\nPrevious studies investigating the relationship between Mycoplasma pneumoniae and incident asthma in the general population have been inconclusive.\n\nOBJECTIVE:\nWe conducted a nationwide cohort study to clarify this relationship.\n\nMETHODS:\nUsing the National Health Ins... |
26815017 | 1 | {
"id": "26815017",
"text": "BACKGROUND:\nThe European Society for Paediatric Gastroenterology, Hepatology and Nutrition recommended in 2008, based on observational data, to avoid both early (<4 months) and late (≥7 months) introduction of gluten and to introduce gluten while the infant is still being breast-fed. N... |
27050141 | 1 | {
"id": "27050141",
"text": "IMPORTANCE:\nDespite the unquestioned relationship of UV radiation (UVR) exposure and melanoma development, UVR-independent development of melanoma has only recently been described in mice. These findings in mice highlight the importance of the genetic background of the host and could b... |
27171547 | 0 | {
"id": "27171547",
"text": "BACKGROUND:\nEarly infantile Krabbe disease is rapidly fatal, but hematopoietic stem cell transplantation (HSCT) may improve outcomes if performed soon after birth. New York State began screening all newborns for Krabbe disease in 2006.\n\nMETHODS:\nInfants with abnormal newborn screen ... |
27286779 | 1 | {
"id": "27286779",
"text": "To summarize the principal findings on risk and protective factors for childhood asthma, we retrieved systematic reviews on these topics in children (aged 1 to 18 years), up to January 2016, through MEDLINE, EMBASE, CINAHL, SCOPUS, and CDSR. A total of 227 studies were searched from dat... |
27626972 | 1 | {
"id": "27626972",
"text": "RATIONALE:\nPreeclampsia reflects an unusual increase in systemic inflammation during pregnancy.\n\nOBJECTIVES:\nWe studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) and in national registries.\n\n... |
27629559 | 1 | {
"id": "27629559",
"text": "OBJECTIVES:\nTo evaluate the risk of BlCa developing after radiation for PCa, stratified by ethnicity and follow-up duration.\n\nMETHODS:\nThe 1973-2011 surveillance, epidemiology and end results database was used to determine the observed and expected number of BlCa after PCa radiation... |
28166365 | 0 | {
"id": "28166365",
"text": "Perampanel (PER) was used in 12 patients with Unverricht-Lundborg disease (ULD) to evaluate its efficacy against myoclonus and seizures."
} |
28228423 | 1 | {
"id": "28228423",
"text": "We previously found that the introduction of small quantities of gluten at 4-6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consumption of high amounts of gluten early in life has been suggested to increase CD risk. The aim of t... |
28579413 | 0 | {
"id": "28579413",
"text": "OBJECTIVE:\nTo study pregnancy chance in adult women with classic galactosemia and primary ovarian insufficiency. Despite dietary treatment, >90% of women with classic galactosemia develop primary ovarian insufficiency, resulting in impaired fertility. For many years, chance of spontane... |
28586371 | 1 | {
"id": "28586371",
"text": "OBJECTIVE:\nThe association between opium use and bladder cancer has been investigated in many studies, with varying reporting results reported. This study aims to estimate the total odds ratio for the association between bladder cancer and opium consumption using meta-analysis.\n\nMETH... |
28746700 | 1 | {
"id": "28746700",
"text": "IMPORTANCE:\nMelanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians.\n\nOBJECTIVE:\nTo determine risk factors and characteristics of renal transplant recipients who develop melanoma.\n\nDESIGN, SETTING, AND PARTICIP... |
28770319 | 1 | {
"id": "28770319",
"text": "AIMS/HYPOTHESIS:\nRespiratory infections and onset of islet autoimmunity are reported to correlate positively in two small prospective studies. The Environmental Determinants of Diabetes in the Young (TEDDY) study is the largest prospective international cohort study on the environmenta... |
28832212 | 0 | {
"id": "28832212",
"text": "BACKGROUND:\nSoft tissue sarcomas (STS) of the hand are exceedingly rare. The aim of this study was to review our institution's experience with STS of the hand to identify factors affecting outcomes and survivorship.\n\nMETHODS:\nWe retrospectively reviewed the records of 46 hand STS tr... |
29055934 | 0 | {
"id": "29055934",
"text": "Sitosterolemia is an autosomal recessive metabolic disease caused by mutations in ABCG5 or ABCG8 genes which encode for the (ATP)-binding cassette (ABC) transporters that are responsible for the trafficking of xenosterols. Liver involvement is not a recognized manifestation of this dise... |
29128935 | 1 | {
"id": "29128935",
"text": "AIMS/HYPOTHESIS:\nWith genetics thought to explain only 40-50% of the total risk of type 1 diabetes, environmental risk factors in early life have been proposed. Previous findings from studies of type 1 diabetes incidence by birthweight and gestational age at birth have been inconsisten... |
29228305 | 1 | {
"id": "29228305",
"text": "BACKGROUND:\nFamily history of bladder cancer confers an increased risk for concordant and discordant cancers in relatives. However, previous studies investigating this relationship lack any correction for smoking status of family members. We conducted a population-based study of cancer... |
29344584 | 0 | {
"id": "29344584",
"text": "Leukodystrophies (LD) are devastating inherited disorders leading to rapid neurological deterioration and premature death. Hematopoietic stem cell transplantation (HSCT) can halt disease progression for selected LD. Cord blood is a common donor source for transplantation of these patien... |
29551552 | 0 | {
"id": "29551552",
"text": "The endothelial lining can be viewed as the first line of defense against risk factors of vascular disease. Endothelial dysfunction is regarded as an initial event for atherogenesis since defects in vascular integrity and homeostasis are responsible for lipid infiltration and recruitmen... |
29650248 | 1 | {
"id": "29650248",
"text": "BACKGROUND:\nAlthough exposure to cigarette smoking and air pollution is common, the current prevalence of chronic obstructive pulmonary disease (COPD) is unknown in the Chinese adult population. We conducted the China Pulmonary Health (CPH) study to assess the prevalence and risk facto... |
29706374 | 1 | {
"id": "29706374",
"text": "BACKGROUND:\nThe management and life expectancy of patients with cystic fibrosis have improved substantially in the past three decades, which has resulted in an increased number of these patients being diagnosed with malignancies. Our aim was to assess the risk of gastrointestinal cance... |
29941778 | 1 | {
"id": "29941778",
"text": "Celiac disease is a small intestinal inflammatory disease with autoimmune features that is triggered and maintained by the ingestion of the storage proteins (gluten) of wheat, barley, and rye. Prevalence of celiac disease is increased in patients with mono- and/or polyglandular autoimmu... |
29972110 | 0 | {
"id": "29972110",
"text": "With the increase in long-term survival of post-transplant children, there is a paradigm shift in the emphasis of post-transplant care."
} |
30124939 | 1 | {
"id": "30124939",
"text": "OBJECTIVES:\nTo investigate the link between smoking status, including childhood and adult passive exposure, and the risk of incident RA.\n\nMETHODS:\nThe French E3N cohort includes 98 995 female volunteers prospectively followed since 1990. Self-administered questionnaires sent every 2... |
30267597 | 0 | {
"id": "30267597",
"text": "OBJECTIVE AND METHODS:\nPediatric-inspired regimens have been adopted by several groups as the treatment strategy for adult patients with acute lymphoblastic leukemia (ALL). Whether subsequent modifications of these protocols have led to an improvement in the outcome of patients is unce... |
30477003 | 1 | {
"id": "30477003",
"text": "IMPORTANCE:\nTwo pathways have been hypothesized for the development of cutaneous melanoma: one typically affects the head and neck, a site with chronic sun damage, and the other affects the trunk, which is less exposed to the sun. However, the possible cause of limb melanomas is less s... |
30760441 | 1 | {
"id": "30760441",
"text": "OBJECTIVE:\nTo determine whether infection with human enterovirus or adenovirus, both common intestinal viruses, predicts development of coeliac disease.\n\nDESIGN:\nCase-control study nested within Norwegian birth cohort recruited between 2001 and 2007 and followed to September 2016.\n... |
30760605 | 1 | {
"id": "30760605",
"text": "OBJECTIVES:\nFarming has been associated with rheumatoid arthritis (RA). Some studies have evaluated the effects of pesticides, but other agricultural exposures may also affect immune response.\n\nMETHODS:\nWe investigated non-pesticide agricultural exposures in relation to RA in licens... |
30790475 | 1 | {
"id": "30790475",
"text": "OBJECTIVE:\nTo investigate the impact and timing of smoking cessation on developing rheumatoid arthritis (RA) and serologic phenotypes.\n\nMETHODS:\nWe investigated smoking cessation and RA risk in the Nurses' Health Study (NHS) (1976-2014) and the NHS II (1989-2015). Smoking exposures ... |
30792131 | 0 | {
"id": "30792131",
"text": "Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease."
} |
30922351 | 0 | {
"id": "30922351",
"text": "BACKGROUND:\nExtremity myxoid liposarcoma (MLS) is a rare soft tissue sarcoma in adults. We performed this study to define distinctive clinical features of extremity MLS by assessing prognostic factors.\n\nMETHODS:\nBetween 1973 and 2015, 1756 patients with extremity MLS who underwent s... |
31250012 | 1 | {
"id": "31250012",
"text": "BACKGROUND:\nThe role of Helicobacter pylori (H. pylori) infection in the development of colorectal neoplasia has been a matter of scientific debate with controversial findings.\n\nAIMS:\nThis study examined the association between H. pylori infection and colorectal cancer (CRC) in a na... |
31371090 | 0 | {
"id": "31371090",
"text": "Herein it is hypothesized that M2-like macrophages or pre-macrophages of fetal origin might play a central role in development and closure of the neural tube. Early in embryonic development, pre-macrophages arise from the fetal yolk sac and track through the bloodstream to reach diverse... |
31665782 | 0 | {
"id": "31665782",
"text": "Analyses of the global spatial and temporal distribution of enteric fever outbreaks worldwide are important factors to consider in estimating the disease burden of enteric fever disease burden."
} |
31804006 | 0 | {
"id": "31804006",
"text": "Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of acute leukemias that account for about one third of all cases of Philadelphia chromosome (Ph)-negative ALL. Recently, a molecular classifier using the mutational status of NOTCH1, FBXW7, RAS, and PTEN (NFRP) h... |
31939580 | 0 | {
"id": "31939580",
"text": "Hereditary spastic paraplegias (HSP) are a group of genetic diseases characterized by lower limb spasticity with or without additional neurological features. Swallowing dysfunction is poorly studied in HSP and its presence can lead to significant respiratory and nutritional complication... |
32210617 | 0 | {
"id": "32210617",
"text": "Phosphoinositide 3-kinase (PI3K) and the downstream Akt/mammalian target of rapamycin (mTOR) pathway are central to the control of cell proliferation and survival. Although abnormal activation of this pathway has been well established in a variety of tumours, limited studies are availab... |
32816888 | 0 | {
"id": "32816888",
"text": "BACKGROUND AND OBJECTIVES:\nC3 glomerulopathy is a complement-mediated disease arising from abnormalities in complement genes and/or antibodies against complement components. Previous studies showed that treatment with corticosteroids plus mycophenolate mofetil (MMF) was associated with... |
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