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5,134,561 | Comparison between thermography and fluorescein test in the detection of incompetent perforating veins. | Elem B B, Shorey B A BA, Williams K L KL | British medical journal . Vol. 4, No. 5788, 1971 Dec 11 | Incompetent perforating veins of the legs were located by dynamic thermography at 69 sites and by the fluorescein test at 31. All the sites were explored by multiple local incisions. Incompetence of the veins was determined by demonstrating retrograde blood flow through these veins when severed. Explorations of these s... | https://pubmed.ncbi.nlm.nih.gov/5134561/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 5134561 |
5,135,250 | Clinical trial of mefruside, a new diuretic. | Auld W H WH, Murdoch W R WR | British medical journal . Vol. 4, No. 5790, 1971 Dec 25 | A controlled clinical trial of a new diuretic-mefruside-is reported, in which it was compared with frusemide in 15 normal subjects and 15 patients with fluid retention. It was found to be an effective diuretic which, in the patients, produced a significantly greater excretion of water and electrolytes than an equal dos... | https://pubmed.ncbi.nlm.nih.gov/5135250/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5135250 |
5,531,862 | The effect of ethyl alcohol and chlorpromazine on the response of the hand blood vessels to cold. | Downey J A JA, Frewin D B DB | British journal of pharmacology . Vol. 40, No. 3, 1970 Nov | 1. The response of hand blood flow to a measured cold stimulus was determined using venous occlusion plethysmography in normal subjects, before and after orally administered alcohol, and in patients on chlorpromazine therapy.2. The average resting hand blood flow of the patients taking chlorpromazine, as well as the co... | https://pubmed.ncbi.nlm.nih.gov/5531862/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 5531862 |
5,539,179 | A within-patient comparison of debrisoquine and methyldopa in hypertension. | Heffernan A A, Carty A A, O'Malley K K, Bugler J J | British medical journal . Vol. 1, No. 5740, 1971 Jan 09 | In a titrated dose cross-over trial of debrisoquine and methyldopa in 38 hypertensive patients neither drug was superior in lowering supine or standing diastolic pressure with a minimum of side effects. Methyldopa caused significantly greater reduction of supine (P<0.001) and standing (P<0.02) systolic pressure but cau... | https://pubmed.ncbi.nlm.nih.gov/5539179/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 5539179 |
5,540,117 | Comparison of the effects of chlorpromazine, dextroamphetamine and methylphenidate on the behaviour and intellectual functioning of hyperactive children. | Weiss G G, Minde K K, Douglas V V, Werry J J, Sykes D D | Canadian Medical Association journal . Vol. 104, No. 1, 1971 Jan 09 | Chlorpromazine, dextroamphetamine and methylphenidate were significantly superior to placebo in producing overall improvement in the behaviour of hyperactive children. Chlorpromazine was effective for the majority of the children, but reduced only hyperactivity, having no demonstrable effect on distractibility, aggress... | https://pubmed.ncbi.nlm.nih.gov/5540117/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 5540117 |
5,543,994 | Myocardial infarction and deep-vein thrombosis. | Nicolaides A N AN, Kakkar V V VV, Renney J T JT, Kidner P H PH, Hutchison D C DC, Clarke M B MB | British medical journal . Vol. 1, No. 5746, 1971 Feb 20 | In a study of 52 patients admitted into the coronary intensive care unit the incidence of deep-vein thrombosis was measured with the (125)I-fibrinogen test. Of these patients 31 were eventually confirmed to be suffering from acute myocardial infarction. This preliminary study showed that in patients with a confirmed in... | https://pubmed.ncbi.nlm.nih.gov/5543994/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5543994 |
5,338,884 | A clinical trial of four hypnotic drugs. | le Riche W H WH, Csima A A, Dobson M M | Canadian Medical Association journal . Vol. 95, No. 7, 1966 Aug 13 | A CLINICAL TRIAL OF FOUR HYPNOTIC DRUGS WAS CARRIED OUT: Ro 4-5360, 10 mg. (Mogadon), methyprylon, 200 mg. (Noludar), Ro 4-5360, 5 mg. (Mogadon), secobarbital sodium, 100 mg. (Seconal), and a placebo. The study was on the usual double-blind basis, and all observations were made by a full-time nurse. Capsules were given... | https://pubmed.ncbi.nlm.nih.gov/5338884/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 5338884 |
5,341,676 | Oxyphenbutazone (tandearil) in rhinoplasty. A clinical evaluation of effectiveness. | Bailey B J BJ, Nahum A M AM | California medicine . Vol. 105, No. 4, 1966 Oct | To evaluate the effectiveness of Oxyphenbutazone as an anti-inflammatory agent, a double-blind study of Oxyphenbutazone and a placebo in a group of 42 patients who had nasal cosmetic operations involving osteotomy was carried out. The observations included direct objective measurement of the width of the palpebral fiss... | https://pubmed.ncbi.nlm.nih.gov/5341676/ | [
"Clinical Trial",
"Journal Article"
] | 5341676 |
5,343,357 | The metabolism of orally administered L-Dopa in Parkinsonism. | Calne D B DB, Karoum F F, Ruthven C R CR, Sandler M M | British journal of pharmacology . Vol. 37, No. 1, 1969 Sep | 1. Gas-liquid chromatographic methods were used to measure urinary acidic and alcoholic metabolites of L-DOPA, which had been administered in high oral dosage to patients with postencephalitic and idiopathic Parkinsonism.2. The output of these compounds was normal before treatment. During drug therapy, large quantities... | https://pubmed.ncbi.nlm.nih.gov/5343357/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5343357 |
5,345,935 | Earlier diagnosis and survival in lung cancer. | Brett G Z GZ | British medical journal . Vol. 4, No. 5678, 1969 Nov 01 | In a controlled investigation the survival prospects of lung cancer in a population of men aged 40 and over who had been offered six-monthly chest radiographs over a period of three years were compared with lung cancer in a similar population without such x-ray facilities. The five-year survival rate of lung cancer in ... | https://pubmed.ncbi.nlm.nih.gov/5345935/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5345935 |
5,350,103 | Gastric acid secretion in patients with duodenal ulcer treated for one year with anticholinergic drugs. | Kaye M D MD, Beck P P, Rhodes J J, Sweetnam P M PM | Gut . Vol. 10, No. 10, 1969 Oct | Ninety patients with duodenal ulcer, divided randomly into three groups, were treated continuously for one year with either glycopyrronium, 1-hyoscyamine (as a sustained-release preparation) or inert tablets. Dosage with active tablets was so adjusted that the patient experienced definite but tolerable side-effects. Ba... | https://pubmed.ncbi.nlm.nih.gov/5350103/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 5350103 |
5,354,851 | Absorption of therapeutic preparations of iron measured with a whole body counter. | Callender S T ST, Warner G T GT | British medical journal . Vol. 4, No. 5682, 1969 Nov 29 | The Oxford Whole Body Counter was used to measure absorption from various therapeutic preparations of iron in five groups of subjects. Succinic acid enhanced absorption of iron when added to a solution of ferrous fumarate, but not when given with tablets of ferrous fumarate or ferrous sulphate. Ferrous fumarate plus as... | https://pubmed.ncbi.nlm.nih.gov/5354851/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 5354851 |
5,354,874 | Renal excretion of calcium and sodium in acute nephritis. | Wilson R J RJ | British medical journal . Vol. 4, No. 5685, 1969 Dec 20 | Hypocalciuria was found in the early stages of illness in six patients aged 12 to 30 with acute nephritis. The hypocalciuria does not appear to be due to hypocalcaemia, lowered glomerular filtration rate, or hypoparathyroidism. It is suggested that the hypocalciuria is due in part to decreased intestinal absorption of ... | https://pubmed.ncbi.nlm.nih.gov/5354874/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5354874 |
5,354,877 | Effect on airways resistance of prostaglandin E1 given by aerosol to healthy and asthmatic volunteers. | Cuthbert M F MF | British medical journal . Vol. 4, No. 5685, 1969 Dec 20 | The forced expiratory volume in one second (F.E.V.(1)) was measured in healthy and asthmatic volunteers and the inhalation of prostaglandin E(1) (PGE(1)) was compared with that of isoprenaline, using metered aerosols.In healthy volunteers PGE(1), either as the free acid or the neutral triethanolamine salt, did not affe... | https://pubmed.ncbi.nlm.nih.gov/5354877/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 5354877 |
5,356,547 | Effect of drugs on urate binding to plasma proteins. | Bluestone R R, Kippen I I, Klinenberg J R JR | British medical journal . Vol. 4, No. 5683, 1969 Dec 06 | The effect of various drugs on urate binding to plasma proteins was investigated in normal subjects. Whereas allopurinol, aspirin, phenylbutazone, probenecid, and sulphinpyrazone all significantly reduced plasma urate concentrations, only aspirin, phenylbutazone, and probenecid significantly impaired urate binding. Col... | https://pubmed.ncbi.nlm.nih.gov/5356547/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5356547 |
5,356,549 | Proteins and insulin release: a dual role of amino-acids and intestinal hormones. | Jarrett R J RJ, Graver H J HJ, Cohen N M NM | British medical journal . Vol. 4, No. 5683, 1969 Dec 06 | In two subjects concurrent infusion of amino-acids and the hormones secretin and pancreozymin provoked much higher plasma insulin levels than did administration of amino-acids or hormones individually. It is suggested that this may be a physiological phenomenon, augmenting the release of insulin from the pancreas after... | https://pubmed.ncbi.nlm.nih.gov/5356549/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 5356549 |
3,954,392 | Intralesional recombinant alpha-2 interferon for the treatment of patients with condyloma acuminatum or verruca plantaris. | Vance J C JC, Bart B J BJ, Hansen R C RC, Reichman R C RC, McEwen C C, Hatch K D KD, Berman B B, Tanner D J DJ | Archives of dermatology . Vol. 122, No. 3, 1986 Mar | We conducted a multicenter double-blind study comparing human recombinant intralesional alpha-2 interferon (IFN) and placebo in 237 patients with the clinical diagnosis of condyloma acuminatum or verruca plantaris. A single wart on each patient was injected with 0.1 mL containing 10(6) IU of IFN, 10(5) IU of IFN, or pl... | https://pubmed.ncbi.nlm.nih.gov/3954392/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3954392 |
3,954,551 | Signs and symptoms of tobacco withdrawal. | Hughes J R JR, Hatsukami D D | Archives of general psychiatry . Vol. 43, No. 3, 1986 Mar | To test the validity, magnitude, and clinical significance of the signs and symptoms of tobacco withdrawal defined by DSM-III, both observed and reported signs and symptoms were measured in 50 smokers during two days of ad lib smoking and then during the first four days of abstinence. Observer and subject ratings of th... | https://pubmed.ncbi.nlm.nih.gov/3954551/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] | 3954551 |
3,954,590 | Shoulder harness traction for roentgenographic assessment of the cervical spine. | Norris C S CS, Silva W E WE, Dodson T F TF, Darrow J J | Archives of surgery (Chicago, Ill. : 1960) . Vol. 121, No. 4, 1986 Apr | We evaluated the clinical usefulness of a new shoulder traction device to facilitate a rapid complete cervical spine examination in an uncooperative patient population with multiple trauma. Forty-eight patients were randomly designated to receive the shoulder traction device or the standard technique (manual traction o... | https://pubmed.ncbi.nlm.nih.gov/3954590/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3954590 |
3,954,815 | Influence of tasuldine and acetylcysteine on mucociliary clearance in patients with chronic airways obstruction. | Dorow P P, Weiss T T, Felix R R, Köhler M M | Arzneimittel-Forschung . Vol. 36, No. 1, 1986 | In a single-blind intraindividual cross-over comparative study the influence of two systemic-mucolytic agents, 2-(pyridyl-3-methylthio)pyrimidine (tasuldine, HE 10004-succinate) vs. N-acetyl-L-cysteine (acetylcysteine) on the mucociliary clearance and lung function was investigated in 15 patients with chronic obstructi... | https://pubmed.ncbi.nlm.nih.gov/3954815/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3954815 |
3,954,834 | Alcohol enhances vitamin C excretion in the urine. | Faizallah R R, Morris A I AI, Krasner N N, Walker R J RJ | Alcohol and alcoholism (Oxford, Oxfordshire) . Vol. 21, No. 1, 1986 | Urinary ascorbic acid excretion was measured on four consecutive days in 9 normal male volunteers for 4 hr before and after drinking nothing (control), 0.58 g alcohol/kg body wt as whisky or lager or water (11./70 kg body wt). The normal reduction in ascorbic acid excretion under control conditions was abolished by dri... | https://pubmed.ncbi.nlm.nih.gov/3954834/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3954834 |
3,954,918 | Isoflurane and halothane for outpatient dental anaesthesia in children. | Cattermole R W RW, Verghese C C, Blair I J IJ, Jones C J CJ, Flynn P J PJ, Sebel P S PS | British journal of anaesthesia . Vol. 58, No. 4, 1986 Apr | A trial was undertaken in children to compare the use of halothane and isoflurane in outpatient dental anaesthesia. A wholly inhalation technique was chosen and nitrous oxide in oxygen was delivered from a Boyle's machine via a coaxial (Bain) breathing system and was supplemented with either halothane or isoflurane. Is... | https://pubmed.ncbi.nlm.nih.gov/3954918/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3954918 |
3,954,920 | Comparison of the incidence and nature of cardiac arrhythmias occurring during isoflurane or halothane anaesthesia. Studies during dental surgery. | Rodrigo M R MR, Moles T M TM, Lee P K PK | British journal of anaesthesia . Vol. 58, No. 4, 1986 Apr | Seventy-six Chinese patients aged between 15 and 30 yr, undergoing 3rd molar extraction, were randomly allocated to two groups. One group received halothane and the other isoflurane. The incidence of arrhythmia during surgery under anaesthesia with isoflurane was significantly less than with halothane. Sinus tachycardi... | https://pubmed.ncbi.nlm.nih.gov/3954920/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3954920 |
3,954,919 | Comparison of isoflurane and halothane in outpatient paediatric dental anaesthesia. | McAteer P M PM, Carter J A JA, Cooper G M GM, Prys-Roberts C C | British journal of anaesthesia . Vol. 58, No. 4, 1986 Apr | Isoflurane was compared with halothane as the sole supplement to anaesthesia with nitrous oxide and oxygen for outpatient dental extractions in 80 children. Induction and maintenance of anaesthesia were satisfactory with both agents, although there was a higher incidence of coughing, salivation and laryngospasm in the ... | https://pubmed.ncbi.nlm.nih.gov/3954919/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3954919 |
3,954,933 | Intra- and inter-individual variation in pharmacokinetics of intravenously infused amoxycillin and ampicillin to elderly volunteers. | Sjövall J J, Alván G G, Huitfeldt B B | British journal of clinical pharmacology . Vol. 21, No. 2, 1986 Feb | The purpose of this study was to investigate the disposition of two aminopenicillins and their intra- and inter-individual variation in pharmacokinetic parameters in healthy, elderly volunteers. Two groups, each of 12 active, community-dwelling volunteers between 69 and 83 years of age participated. One group was given... | https://pubmed.ncbi.nlm.nih.gov/3954933/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3954933 |
3,954,937 | Hypnotic activity of an imidazo-pyridine (zolpidem). | Nicholson A N AN, Pascoe P A PA | British journal of clinical pharmacology . Vol. 21, No. 2, 1986 Feb | Effects of an imidazo-pyridine (zolpidem: 10, 20 and 30 mg) on overnight sleep and on performance the next day were studied in young adults and in middle aged individuals. The young adults were used particularly as an homogenous group to establish any possible adverse effects of the drug on sleep and on performance the... | https://pubmed.ncbi.nlm.nih.gov/3954937/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3954937 |
3,954,936 | Kinetic and dynamic interaction of brotizolam and ethanol. | Scavone J M JM, Greenblatt D J DJ, Harmatz J S JS, Shader R I RI | British journal of clinical pharmacology . Vol. 21, No. 2, 1986 Feb | Thirteen healthy male volunteers ingested a single 0.25 mg dose of the thienodiazepine hypnotic, brotizolam, on two occasions: once with a typical social cocktail (containing 60 ml of vodka), and in a second trial with an 'ethanol-placebo' cocktail. Brotizolam kinetics were determined from multiple plasma concentration... | https://pubmed.ncbi.nlm.nih.gov/3954936/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] | 3954936 |
3,954,967 | Use of leucocyte-poor blood components and HLA-matched-platelet donors to prevent HLA alloimmunization. | Murphy M F MF, Metcalfe P P, Thomas H H, Eve J J, Ord J J, Lister T A TA, Waters A H AH | British journal of haematology . Vol. 62, No. 3, 1986 Mar | Recent studies have shown that the incidence of alloimmunization due to repeated platelet transfusions from random donors may be reduced by the use of leucocyte-poor blood components. These results were confirmed by this study, where 16% of patients with acute leukaemia undergoing initial chemotherapy and receiving leu... | https://pubmed.ncbi.nlm.nih.gov/3954967/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3954967 |
3,955,198 | Evaluation of two new megestrol acetate tablet formulations in humans. | Gaver R C RC, Pittman K A KA, Reilly C M CM, Goodson P J PJ, Breault G O GO, Fenzl E E | Biopharmaceutics & drug disposition . Vol. 7, No. 1 | The bioequivalence of two new investigational 160 mg tablets, one containing the regular form and the other a micronized form of megestrol acetate, was determined relative to a commercially available 40 mg tablet (Megace). The tablets were administered to 24 male subjects in a three-way cross-over study, balanced for s... | https://pubmed.ncbi.nlm.nih.gov/3955198/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3955198 |
3,955,199 | The pharmacokinetics of oral and intravenous prenalterol in young, healthy volunteers. | Clarke A F AF, Jack D B DB, Kendall M J MJ, Smith S R SR | Biopharmaceutics & drug disposition . Vol. 7, No. 1 | The pharmacokinetics of prenalterol in healthy young volunteers after i.v. and oral dosing has been studied. There is evidence of non-linearity following the i.v. dosing. Evidence of dose-dependent pharmacokinetics following i.v. dosing has been obtained. The sustained-release formulation is very effective: almost 12 h... | https://pubmed.ncbi.nlm.nih.gov/3955199/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3955199 |
3,955,441 | Check ligaments: surgical effects in infantile esotropia. | Noel L P LP, Clarke W N WN | Canadian journal of ophthalmology. Journal canadien d'ophtalmologie . Vol. 21, No. 1, 1986 Feb | In a prospective randomized study, we compared the results of surgical treatment of 25 patients with infantile esotropia, using bilateral medial rectus muscle recession of a graded amount without severing the check ligaments, to results obtained with a similar group of 23 patients in whom check ligaments were severed a... | https://pubmed.ncbi.nlm.nih.gov/3955441/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3955441 |
3,955,536 | Beta-carotene levels in exfoliated human mucosa cells following its oral administration. | Stich H F HF, Hornby A P AP, Dunn B P BP | Cancer letters . Vol. 30, No. 2, 1986 Feb | Beta-carotene levels of exfoliated oral mucosa cells can be increased severalfold by the oral administration of this provitamin. Beta-carotene was estimated by HPLC analysis in pronase-treated exfoliated cells obtained by brushing the entire oral mucosa with a toothbrush. A small percentage of individuals did not respo... | https://pubmed.ncbi.nlm.nih.gov/3955536/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3955536 |
3,955,779 | Comparative clinical evaluation of ceftriaxone in treating lower respiratory tract infections. | Abbate G F GF, Alagia I I, Giaquinto E E, Leonessa V V, Caputi M M, Guarino C C, Micillo E E, Catena E E, Altucci P P | Chemioterapia : international journal of the Mediterranean Society of Chemotherapy . Vol. 5, No. 1, 1986 Feb | To evaluate the clinical and microbiological efficacy and safety of ceftriaxone in comparison with cefotaxime in treating acute lower respiratory tract infections two open randomized trials were performed. Sixty-two adult hospital in-patients were entered and 58 completed the study. The patients suffered from either ac... | https://pubmed.ncbi.nlm.nih.gov/3955779/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3955779 |
3,956,052 | Comparison of four beta-blockers as assessed by 24-hour ECG recording. | Escoubet B B, Leclercq J F JF, Maison-Blanche P P, Poirier J M JM, Gourmel B B, Delhotal-Landes B B, Coumel P P | Clinical pharmacology and therapeutics . Vol. 39, No. 4, 1986 Apr | beta-Blockers are used as if they were equivalent. With ECG recordings in 42 patients we investigated the effect on sinus heart rate of four beta-blockers given at three successive daily doses. Heart rate was dose-dependently decreased by all drugs except acebutolol, the effect of which decreased at a higher dosage. Th... | https://pubmed.ncbi.nlm.nih.gov/3956052/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3956052 |
3,956,056 | Cardiovascular effects of enprofylline and theophylline. | Esquivel M M, Burns R J RJ, Ogilvie R I RI | Clinical pharmacology and therapeutics . Vol. 39, No. 4, 1986 Apr | The cardiovascular effects of enprofylline (with no adenosine receptor antagonism) and of theophylline (with adenosine receptor antagonism) were compared in six normal subjects in a double-blind trial at steady-state concentrations of theophylline (12.5 +/- 1.6 mg/L) and enprofylline (2.7 +/- 0.3 mg/L). The mean (+/- S... | https://pubmed.ncbi.nlm.nih.gov/3956056/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3956056 |
3,956,105 | The measurement of breathlessness induced in normal subjects: individual differences. | Adams L L, Chronos N N, Lane R R, Guz A A | Clinical science (London, England : 1979) . Vol. 70, No. 2, 1986 Feb | Normal subjects show wide variability in their sensory scaling of breathlessness for equivalent degrees of ventilatory stimulation and behave "characteristically' irrespective of stimulus type. Observed differences are not explained by physical characteristics, ventilatory sensitivity or pattern of breathing although t... | https://pubmed.ncbi.nlm.nih.gov/3956105/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 3956105 |
3,956,107 | Haemodynamic effects of vasopressin in man are related to posture. | Simpson H C HC, Zubillaga J E JE, Collier J G JG, Bennett E D ED, Ang V T VT, Mehta N N, Jenkins J S JS | Clinical science (London, England : 1979) . Vol. 70, No. 2, 1986 Feb | Ten healthy volunteers received intravenous infusions of arginine vasopressin (AVP) at 0.1 m-unit min-1 kg-1 and 5% D-glucose on separate days. AVP caused a small fall in forearm blood flow and small rises in mean arterial pressure and systemic vascular resistance. Cardiac output was unaffected. When subjects were tilt... | https://pubmed.ncbi.nlm.nih.gov/3956107/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3956107 |
3,956,111 | Activation of human muscle pyruvate dehydrogenase with activity and immobilization. | Ward G R GR, MacDougall J D JD, Sutton J R JR, Toews C J CJ, Jones N L NL | Clinical science (London, England : 1979) . Vol. 70, No. 2, 1986 Feb | The activity of pyruvate dehydrogenase (PDH) was measured in samples of triceps muscle obtained in 15 males, before and after immobilization for 5 weeks and 5 months of strength training carried out in random order with cross-over of treatment. Although the total PDH activity was unchanged at 300 nmol min-1 g-1, the pr... | https://pubmed.ncbi.nlm.nih.gov/3956111/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3956111 |
3,956,116 | A double-blind study on the effect of discontinuation of gold therapy in patients with rheumatoid arthritis. | Van der Leeden H H, Dijkmans B A BA, Hermans J J, Cats A A | Clinical rheumatology . Vol. 5, No. 1, 1986 Jan | To assess the benefit of further gold treatment of rheumatoid arthritis (RA) patients who had already received more than 6 g of this metal, 24 such patients were included in a double-blind trial. Besides this "gold group" comprising 11 patients who received gold (Auromyose) in the same dosage schedule as before the stu... | https://pubmed.ncbi.nlm.nih.gov/3956116/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3956116 |
3,956,211 | Functional equality of coordinating centers in a multicenter clinical trial. Experience of the International Mexiletine and Placebo Antiarrhythmic Coronary Trial (IMPACT). | Alamercery Y Y, Wilkins P P, Karrison T T | Controlled clinical trials . Vol. 7, No. 1, 1986 Mar | The International Mexiletine and Placebo Antiarrhythmic Coronary Trial (IMPACT) included clinical centers in both Europe and North America. The clinics were monitored by two Regional Coordinating Centers: one located in Baltimore, Maryland, for North American clinics; the other in Lyon, France, for European clinics. Th... | https://pubmed.ncbi.nlm.nih.gov/3956211/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3956211 |
3,956,275 | Suppression of gastric H2-receptor mediated function in patients with bronchial asthma and ragweed allergy. | Gonzalez H H, Ahmed T T | Chest . Vol. 89, No. 4, 1986 Apr | We have previously demonstrated a depression of airway, vascular, and cutaneous H2-histamine receptor function in sheep with experimental allergic asthma. In the present investigation, we wished to determine if there is a depression of gastric H2-receptor function in subjects with allergic bronchial asthma. In eight no... | https://pubmed.ncbi.nlm.nih.gov/3956275/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3956275 |
3,956,454 | A comparison of the toxicity effects of the anticonvulsant eterobarb (antilon, DMMP) and phenobarbital in normal human volunteers. | Smith D B DB, Goldstein S G SG, Roomet A A | Epilepsia . Vol. 27, No. 2 | Renewed corporate interest in the anticonvulsant drug eterobarb justified renewed clinical and experimental interest in this drug. The unique and clinically intriguing feature of eterobarb is that while sharing the anticonvulsant properties of other barbiturates, the hypnotic side effects usually associated with barbit... | https://pubmed.ncbi.nlm.nih.gov/3956454/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3956454 |
3,956,521 | Intrinsic sympathomimetic activity (ISA) of pindolol in patients with sinus node dysfunction. | Viersma J W JW, van den Berg M P MP, van Gilst W H WH, Lie K I KI | European heart journal . Vol. 7, No. 1, 1986 Jan | The effects of pindolol treatment on mean heart rate (MHR) and the number of paced heart beats were investigated in a group of 12 patients, with frequency programmable pacemakers implanted to control symptomatic bradyarrhythmias resulting from sinus node dysfunction. In a randomized double blind cross over experiment t... | https://pubmed.ncbi.nlm.nih.gov/3956521/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3956521 |
3,956,558 | Extradural and parenteral pethidine as analgesia after total hip replacement: effects and kinetics. A controlled clinical study. | Gustafsson L L LL, Johannisson J J, Garle M M | European journal of clinical pharmacology . Vol. 29, No. 5, 1986 | Twenty-one patients who had undergone total hip replacement were randomly assigned to one of three groups in order to compare a single dose of 1 mg/kg of pethidine im (I) and 20 mg (II) or 60 mg of extradural pethidine (III) in a double-blind design. The degree of analgesia, the adverse effects, and the kinetics were s... | https://pubmed.ncbi.nlm.nih.gov/3956558/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3956558 |
3,956,820 | Treatment of hyperhidrosis by a battery-operated iontophoretic device. | Hölzle E E, Ruzicka T T | Dermatologica . Vol. 172, No. 1, 1986 | A new iontophoretic device was utilized in the treatment of hyperhidrosis axillaris (5 patients), hyperhidrosis manuum (12 patients) and hyperhidrosis pedum (10 patients). Unilateral treatment was carried out daily for 3 weeks. Degree of sweat inhibition was assessed quantitatively in relation to the untreated control ... | https://pubmed.ncbi.nlm.nih.gov/3956820/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3956820 |
3,956,833 | Bladder wall mechanics and micturition before and after subtotal and total hysterectomy. | Lalos O O, Bjerle P P | European journal of obstetrics, gynecology, and reproductive biology . Vol. 21, No. 3, 1986 Mar | Twenty-two women were assigned at random to subtotal (n = 11) or total (n = 11) hysterectomy. The frequency of micturition was recorded and urodynamic investigation was performed before, and 6 weeks and 6 months after the operation. After hysterectomy the frequency of diurnal micturition decreased and the urethral cond... | https://pubmed.ncbi.nlm.nih.gov/3956833/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3956833 |
3,956,889 | 24-hour intragastric pH: continuous monitoring or nasogastric aspiration? | Reynolds J R JR, Walt R P RP, Hardcastle J D JD, Clark A G AG, Smart H L HL, Langman M J MJ | Digestion . Vol. 33, No. 4, 1986 | Hourly gastric aspiration has commonly been used to assess the efficacy of antisecretory compounds. We have compared continuous ambulatory 24-hour pH monitoring using a radiotelemetry capsule with standard nasogastric aspiration. Eight studies were performed on four male duodenal ulcer patients in remission receiving e... | https://pubmed.ncbi.nlm.nih.gov/3956889/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 3956889 |
3,956,895 | Long-term physical training in female type 1 (insulin-dependent) diabetic patients: absence of significant effect on glycaemic control and lipoprotein levels. | Wallberg-Henriksson H H, Gunnarsson R R, Rössner S S, Wahren J J | Diabetologia . Vol. 29, No. 1, 1986 Jan | No objective evidence has been presented to support the beneficial effect of physical training on glycaemic control in Type 1 (insulin-dependent) diabetic patients trained two to three times a week for several months. In the present study we examined the possibility that a daily exercise programme would be more suitabl... | https://pubmed.ncbi.nlm.nih.gov/3956895/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3956895 |
3,956,939 | Bile reflux is increased in cigarette smokers. | Müller-Lissner S A SA | Gastroenterology . Vol. 90, No. 5 Pt 1, 1986 May | The effect of cigarette smoking on gastric emptying, gastric secretion, and bile salt reflux was measured in 19 healthy habitual cigarette smokers (greater than or equal to 20 cigarettes per day) and 18 nonsmokers. They were studied both in the fasting state and after being fed a mixed liquid meal. Ten of the smokers w... | https://pubmed.ncbi.nlm.nih.gov/3956939/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3956939 |
3,956,940 | Effects of cisapride on jejunal motor activity in fasting healthy humans. | Stacher G G, Steinringer H H, Schneider C C, Winklehner S S, Mittelbach G G, Gaupmann G G | Gastroenterology . Vol. 90, No. 5 Pt 1, 1986 May | The effects of cisapride on jejunal interdigestive motor activity were studied in 12 healthy men participating in three experiments each. Five minutes after an activity front (phase III) they received, in random double-blind fashion, 10 mg of cisapride, 4 mg of cisapride, or saline placebo by intravenous injection. Mot... | https://pubmed.ncbi.nlm.nih.gov/3956940/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3956940 |
3,957,482 | Downgrading of biochemical and cardiovascular responses to an intravenous infusion of terbutaline following chronic treatment with oral terbutaline. | Smith S R SR, Kendall M J MJ | International journal of clinical pharmacology, therapy, and toxicology . Vol. 24, No. 1, 1986 Jan | Beta 2-agonists are known to cause a range of unwanted biochemical and cardiovascular responses. The present study was designed to investigate the effect of chronic exposure to beta 2-stimulation on the magnitude of these responses produced by an acute challenge with a beta 2-agonist. In this single blind placebo contr... | https://pubmed.ncbi.nlm.nih.gov/3957482/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 3957482 |
3,957,487 | Assessment of bio(in)equivalence of deriphyllin-digoxin in human volunteers. | Bansinath M M, Ghosh S S SS, Shafiqa A A, Shukla V K VK, Chopra K S KS, Mathur V S VS | International journal of clinical pharmacology, therapy, and toxicology . Vol. 24, No. 1, 1986 Jan | Bioavailability of digoxin from the formulations of a fixed dose combination of the glycoside with xanthines was compared with that of "Lanoxin". The in vitro analysis of the fixed dose "Deriphyllin-Digoxin" tablets showed that these tablets had low dissolution even at the end of four hours. The in vivo study had a ran... | https://pubmed.ncbi.nlm.nih.gov/3957487/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3957487 |
3,957,502 | Effectiveness of flunarizine in altering electronystagmographic patterns in migraine patients: a preliminary report. | Pini L A LA, Ferrari A A, Guidetti G G, Galetti G G, Barbieri L L, Sternieri E E | International journal of clinical pharmacology research . Vol. 6, No. 1, 1986 | In this double-blind study versus placebo, the anti-migraine efficacy of flunarizine 20 mg/per os/day for 14 days, followed by 10 mg/per os/day up to 120 days has been evaluated in 30 patients suffering from common and classical migraine. During the trial the vestibular function (slow phase velocity (SPV) and number of... | https://pubmed.ncbi.nlm.nih.gov/3957502/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3957502 |
3,957,518 | Mechanical efficiency of pure positive and pure negative work with special reference to the work intensity. | Aura O O, Komi P V PV | International journal of sports medicine . Vol. 7, No. 1, 1986 Feb | The mechanical efficiencies of pure positive (eta) and pure negative (eta-) work were investigated on a special "sledge ergometer" with 25 and 36 subjects, respectively. The work intensities varied in positive work between 40% and 90% and in negative work from 30% to 120% of the maximum concentric exercise. In 54 exerc... | https://pubmed.ncbi.nlm.nih.gov/3957518/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 3957518 |
3,957,541 | An analysis of the mortality effect in a breast cancer screening study. | Aron J L JL, Prorok P C PC | International journal of epidemiology . Vol. 15, No. 1, 1986 Mar | In order to better understand the effect of breast cancer screening on mortality, we use the theory of competing risks to analyse deaths from the long-term follow-up of the HIP breast cancer screening trial. We conclude that some, but not all, of the breast cancer cases detected early as a result of screening realized ... | https://pubmed.ncbi.nlm.nih.gov/3957541/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3957541 |
3,957,683 | Skills methods to prevent smoking. | Schinke S P SP, Gilchrist L D LD, Schilling R F RF, Snow W H WH, Bobo J K JK | Health education quarterly . Vol. 13, No. 1, 1986 | School health educators have devoted much attention to cigarette smoking. Recent years have seen the testing of interventions to prevent smoking. To date, controlled studies have not evaluated the added value of skills methods for preventing smoking. This article describes such an evaluation with sixth-grade students f... | https://pubmed.ncbi.nlm.nih.gov/3957683/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] | 3957683 |
3,957,686 | Computerized health education: a comparison with traditional formats. | Deardorff W W WW | Health education quarterly . Vol. 13, No. 1, 1986 | The present study compared a computerized health education format to face-to-face and written methods. The effects of delivery method on the retention of health information and on participant evaluation of the condition were assessed. College student participants (N = 200) were randomly assigned to one of four conditio... | https://pubmed.ncbi.nlm.nih.gov/3957686/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3957686 |
3,957,710 | Investigation of vitamin A nutrition in pregnant British Asians and their infants. | Howells D W DW, Haste F F, Rosenberg D D, Brown I R IR, Brooke O G OG | Human nutrition. Clinical nutrition . Vol. 40, No. 1, 1986 Jan | Plasma retinol and retinol-binding protein (RBP) concentrations were lower in 23 South London Asian women of Indo-Pakistani origin than in 21 non-Asian controls during pregnancy (P less than 0.01 and P less than 0.05 respectively). Cord blood concentrations of retinol and RBP were the same in Asians and non-Asians. Pla... | https://pubmed.ncbi.nlm.nih.gov/3957710/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3957710 |
3,957,880 | Atropine and glycopyrrolate as ECT preanesthesia. | Kramer B A BA, Allen R E RE, Friedman B B | The Journal of clinical psychiatry . Vol. 47, No. 4, 1986 Apr | Twenty-four patients receiving ECT were systematically studied to compare the effects of two dosages of atropine and two dosages of glycopyrrolate as preanesthetic agents. Glycopyrrolate resulted in more cardiac arrhythmias, nausea and vomiting, and episodes of bradycardia than atropine (p = .4). More patients receivin... | https://pubmed.ncbi.nlm.nih.gov/3957880/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3957880 |
3,958,225 | Enhanced bioavailability of triazolam following sublingual versus oral administration. | Scavone J M JM, Greenblatt D J DJ, Friedman H H, Shader R I RI | Journal of clinical pharmacology . Vol. 26, No. 3, 1986 Mar | The rate and extent of the absorption of triazolam following sublingual and oral administration were evaluated in this study. Eight healthy volunteers received triazolam 0.5 mg in a commercially available tablet, by sublingual and oral routes on two occasions in random sequence. Plasma triazolam concentrations during 2... | https://pubmed.ncbi.nlm.nih.gov/3958225/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] | 3958225 |
3,958,345 | Comparison of high pulse repetition frequency and continuous wave Doppler echocardiography for velocity measurement and gradient prediction in children with valvular and congenital heart disease. | Snider A R AR, Stevenson J G JG, French J W JW, Rocchini A P AP, Dick M M, Rosenthal A A, Crowley D C DC, Beekman R H RH, Peters J J | Journal of the American College of Cardiology . Vol. 7, No. 4, 1986 Apr | To compare the ability of high pulse repetition frequency and continuous wave Doppler echocardiography to detect the peak velocity of a jet flow disturbance and to predict pressure gradients accurately, two groups of children with valvular or congenital heart disease were examined using both Doppler techniques. The use... | https://pubmed.ncbi.nlm.nih.gov/3958345/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3958345 |
3,958,384 | Theophylline partially inhibits bronchoconstriction caused by inhaled histamine in subjects with asthma. | Cartier A A, Lemire I I, L'Archevêque J J, Ghezzo H H, Martin R R RR, Malo J L JL | The Journal of allergy and clinical immunology . Vol. 77, No. 4, 1986 Apr | Sixteen adult subjects in a clinical steady state had four consecutive histamine inhalation tests on the same day when they were not receiving oral theophylline medication. The provocative concentration of histamine causing a 20% fall in FEV1 (PC20) was used to assess the response. They were then administered active or... | https://pubmed.ncbi.nlm.nih.gov/3958384/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3958384 |
3,958,660 | Human coffee drinking: manipulation of concentration and caffeine dose. | Griffiths R R RR, Bigelow G E GE, Liebson I A IA, O'Keeffe M M, O'Leary D D, Russ N N | Journal of the experimental analysis of behavior . Vol. 45, No. 2, 1986 Mar | In a residential research ward coffee drinking was studied in 9 volunteer human subjects with histories of heavy coffee drinking. A series of five experiments was undertaken to characterize adlibitum coffee consumption and to investigate the effects of manipulating coffee concentration, caffeine dose per cup, and caffe... | https://pubmed.ncbi.nlm.nih.gov/3958660/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] | 3958660 |
3,958,683 | A randomized trial of special packaging of antihypertensive medications. | Becker L A LA, Glanz K K, Sobel E E, Mossey J J, Zinn S L SL, Knott K A KA | The Journal of family practice . Vol. 22, No. 4, 1986 Apr | This article reports a randomized controlled trial designed to test the effects of special packaging of antihypertensive medication on compliance and blood pressure control. One hundred eighty subjects who had exhibited elevated blood pressure greater than 90 mmHg in the two years prior to the study were recruited from... | https://pubmed.ncbi.nlm.nih.gov/3958683/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] | 3958683 |
3,958,753 | Recombinant interferon alpha-2 (INTRON A) in a phase II study of renal cell carcinoma. | Kempf R A RA, Grunberg S M SM, Daniels J R JR, Skinner D G DG, Venturi C L CL, Spiegel R R, Neri R R, Greiner J M JM, Rudnick S S, Mitchell M S MS | Journal of biological response modifiers . Vol. 5, No. 1, 1986 Feb | Because two of five patients with renal cell carcinoma in a Phase I study had partial response to recombinant alpha-2 interferon (IFN), we treated 26 patients with advanced renal cell carcinoma with a 3-month regimen of IFN. Patients were randomized to receive IFN either subcutaneously (2 X 10(6) IU/m2 3 times a week) ... | https://pubmed.ncbi.nlm.nih.gov/3958753/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3958753 |
3,958,828 | Improved erythrocyte survival with combined vitamin E and selenium therapy in children with glucose-6-phosphate dehydrogenase deficiency and mild chronic hemolysis. | Hafez M M, Amar E S ES, Zedan M M, Hammad H H, Sorour A H AH, el-Desouky E S ES, Gamil N N | The Journal of pediatrics . Vol. 108, No. 4, 1986 Apr | To study the antioxidant effect of high-dose vitamin E alone and in combination with selenium in patients with glucose-6-phosphate dehydrogenase deficiency with mild chronic hemolysis, 36 male children with such manifestations were enrolled consecutively into two equal groups. Group 1 received 800 IU vitamin E daily, a... | https://pubmed.ncbi.nlm.nih.gov/3958828/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3958828 |
3,958,952 | A prospective comparison of Amvisc and Healon in cataract surgery. | Sharpe E D ED, Simmons R J RJ | Journal of cataract and refractive surgery . Vol. 12, No. 1, 1986 Jan | A prospective, randomly assigned, double-masked study was designed to compare two solutions of sodium hyaluronate--Amvisc and Healon. All cases were planned extracapsular cataract extractions with posterior chamber intraocular lenses performed by a single surgeon in glaucomatous and nonglaucomatous eyes. Subjective per... | https://pubmed.ncbi.nlm.nih.gov/3958952/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3958952 |
3,959,099 | Measurement of therapy outcome and maintenance of gains in the behavioral treatment of secondary orgasmic dysfunction. | Fichten C S CS, Libman E E, Brender W W | Journal of sex & marital therapy . Vol. 12, No. 1, 1986 | Choice of therapeutic goals and criteria used for evaluation of therapeutic outcome represent fundamental conceptual and methodological issues. The present investigation examined the relationship between how data were obtained (by retrospective questionnaire or ongoing daily self-monitoring), what outcome criteria were... | https://pubmed.ncbi.nlm.nih.gov/3959099/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3959099 |
3,959,249 | Oxybutynin versus propantheline in patients with multiple sclerosis and detrusor hyperreflexia. | Gajewski J B JB, Awad S A SA | The Journal of urology . Vol. 135, No. 5, 1986 May | Hyperreflexia is the most common urological finding in patients with multiple sclerosis. A prospective randomized study was done to compare the effectiveness of 2 commonly used drugs, oxybutynin and propantheline. Of the 34 patients entered into the trial 19 were treated with oxybutynin and 15 with propantheline. The u... | https://pubmed.ncbi.nlm.nih.gov/3959249/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3959249 |
3,959,273 | Surgical management of synchronous carotid and coronary artery disease. | Cosgrove D M DM, Hertzer N R NR, Loop F D FD | Journal of vascular surgery . Vol. 3, No. 4, 1986 Apr | To determine the safest method of treating simultaneously occurring coronary artery disease and asymptomatic carotid stenosis, patients were randomly assigned to either combined operation or a staged procedure with coronary artery surgery done first, followed by carotid endarterectomy. In the initial 70 patients, there... | https://pubmed.ncbi.nlm.nih.gov/3959273/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3959273 |
3,959,323 | Lack of modulation of postoperative immunosuppression by isotonic amino acid infusion. | Neuvonen P P, Salo M M, Perttilä J J, Havia T T | JPEN. Journal of parenteral and enteral nutrition . Vol. 10, No. 2 | Effects of an isotonic amino acid solution on the immune defence systems of surgical patients were studied. Twenty-two patients admitted for major abdominal operations were randomly allocated into two groups. Eleven of them received 1 liter of 3% amino acid solution daily for 5 days postoperatively, while 11 control pa... | https://pubmed.ncbi.nlm.nih.gov/3959323/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3959323 |
3,959,558 | The effect of alcohol on self-evaluation and perception of negative interpersonal feedback. | Yankofsky L L, Wilson G T GT, Adler J L JL, Hay W M WM, Vrana S S | Journal of studies on alcohol . Vol. 47, No. 1, 1986 Jan | Recent theories of alcohol use and misuse assume that alcohol alters cognitive-perceptual mediating processes that indirectly reduce emotional distress. One view is that alcohol enhances perceptions of control and power. Alternatively, it has been suggested that alcohol is used to reduce self-awareness, perceptions of ... | https://pubmed.ncbi.nlm.nih.gov/3959558/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] | 3959558 |
3,959,564 | The perception of empathy in alcoholism counselors. | Kirk W G WG, Best J B JB, Irwin P P | Journal of studies on alcohol . Vol. 47, No. 1, 1986 Jan | Alcoholic inpatients evaluated the level of empathy demonstrated by a purported alcoholism counselor. Forty-two detoxified subjects viewed a 15-min videotape of a simulated alcoholism counseling session. Subjects had been randomly assigned to one of two groups: Group 1 was told that the counselor they were about to see... | https://pubmed.ncbi.nlm.nih.gov/3959564/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3959564 |
3,959,571 | Arterial line filtration during cardiopulmonary bypass. Neurologic, neuropsychologic, and hematologic studies. | Aris A A, Solanes H H, Cámara M L ML, Junqué C C, Escartin A A, Caralps J M JM | The Journal of thoracic and cardiovascular surgery . Vol. 91, No. 4, 1986 Apr | One hundred patients who underwent elective cardiac operations were randomized into two groups. Group 1 had a 20 micron nylon screen filter in the arterial line. In Group 2 no filter was used in the arterial line. Neurologic and neuropsychologic examination of the patients was performed with seven psychometric tests of... | https://pubmed.ncbi.nlm.nih.gov/3959571/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3959571 |
3,959,854 | Effect of blood pH on peripheral and central signals of perceived exertion. | Robertson R J RJ, Falkel J E JE, Drash A L AL, Swank A M AM, Metz K F KF, Spungen S A SA, LeBoeuf J R JR | Medicine and science in sports and exercise . Vol. 18, No. 1, 1986 Feb | Ten male subjects underwent exercise testing in three modes, arms (A), legs (L), and arms + legs (A + L), after ingesting 0.3 g X kg-1 body weight of either NaHCO3 to induce alkalosis or CaCO3 as a placebo (i.e., six exercise trials). Ratings of perceived exertion (RPE: Borg, 15-pt scale) for the arms (RPE-A), legs (RP... | https://pubmed.ncbi.nlm.nih.gov/3959854/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3959854 |
3,959,968 | Buprenorphine: a new maintenance opiate? | Seow S S SS, Quigley A J AJ, Ilett K F KF, Dusci L J LJ, Swensen G G, Harrison-Stewart A A, Rappeport L L | The Medical journal of Australia . Vol. 144, No. 8, 1986 Apr 14 | Heroin-dependent out-patients who had been prescribed buprenorphine by general practitioners took part in a controlled study in which 2 mg or 4 mg of buprenorphine were administered by the sublingual route to assess its acceptability as a maintenance opiate and to determine the effects of its abrupt withdrawal and rein... | https://pubmed.ncbi.nlm.nih.gov/3959968/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3959968 |
3,960,242 | Exercise training reduces coronary risk and effectively rehabilitates hemodialysis patients. | Goldberg A P AP, Geltman E M EM, Gavin J R JR, Carney R M RM, Hagberg J M JM, Delmez J A JA, Naumovich A A, Oldfield M H MH, Harter H R HR | Nephron . Vol. 42, No. 4, 1986 | This study examines the effects of 12 months of endurance exercise training (cycling, walking and jogging) on lipid profiles, glucose metabolism, blood pressure, anemia and psychological function in 14 hemodialysis patients. Maximal aerobic capacity (VO2max) increased 18% in the exercisers (p less than 0.01), but did n... | https://pubmed.ncbi.nlm.nih.gov/3960242/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] | 3960242 |
3,960,427 | Effect of irrigation or intravenous antibiotic prophylaxis on infectious morbidity at cesarean section. | Gonen R R, Samberg I I, Levinski R R, Levitan Z Z, Sharf M M | Obstetrics and gynecology . Vol. 67, No. 4, 1986 Apr | The efficacy of intraoperative irrigation with cefamandole nafate at cesarean section was evaluated in a prospective, randomized double-blind study. Two hundred and eight patients were treated with antibiotic irrigation and intravenous placebo or with perioperative intravenous cefamandole and irrigated with normal sali... | https://pubmed.ncbi.nlm.nih.gov/3960427/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3960427 |
3,960,476 | Experiences with the Neodymium: YAG laser: interruption of anterior hyaloid membrane of the vitreous and cystoid macular edema. | Alpar J J JJ | Ophthalmic surgery . Vol. 17, No. 3, 1986 Mar | Patients who needed posterior capsulectomy at different times following cataract surgery were treated with: The Meditec OPL3 mode-locked Nd:YAG laser; The LASAG Microruptor 2 Q-switched Nd:YAG laser. Random selection determined which instrument should be used for which patient. Further random selection determined the u... | https://pubmed.ncbi.nlm.nih.gov/3960476/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3960476 |
3,960,619 | Zinc and copper balances in preterm infants. | Tyrala E E EE | Pediatrics . Vol. 77, No. 4, 1986 Apr | Preterm infants are at risk for copper and zinc depletion if sufficient quantities of these nutrients are not provided in a bioavailable form in postnatal life. The purpose of this study was to determine whether the use of a whey-predominant, 50% medium chain triglyceride formula with relatively high concentrations of ... | https://pubmed.ncbi.nlm.nih.gov/3960619/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3960619 |
3,960,944 | A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma. | Dawson K P KP | Pharmatherapeutica . Vol. 4, No. 7, 1986 | Sixty-one chronic asthmatic children received either a new slow-release sprinkle format of theophylline, twice daily, or theophylline liquid, 4-times per day. Over a study period of three months, there was no measurable difference in compliance or symptom control between the two groups. The sprinkle-treated patients, h... | https://pubmed.ncbi.nlm.nih.gov/3960944/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3960944 |
3,960,979 | Influence of aerobic fitness on cardiovascular responses during slow head-down tilting. | Sobush D C DC, Nosse L J LJ, Davis A S AS | Physical therapy . Vol. 66, No. 4, 1986 Apr | This study examined the influence of cardiorespiratory fitness (CRF) on mean heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) responses to slow head-down tilting. Twenty-four young, healthy volunteers were tilted randomly from the horizontal plane to -30, -60, and -90 degrees with lowe... | https://pubmed.ncbi.nlm.nih.gov/3960979/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3960979 |
3,961,002 | Dose-dependent effects of hydrocortisone on memory in human males. | Beckwith B E BE, Petros T V TV, Scaglione C C, Nelson J J | Physiology & behavior . Vol. 36, No. 2, 1986 | Eighty male undergraduates were administered either glucose or 5, 10, 20, or 40 mg of hydrocortisone in a double-blind procedure. After 60 min they were asked to listen to eight 12 word lists and then asked to recall the words. In addition to the expected effects of rate of presentation, serial position, and practice t... | https://pubmed.ncbi.nlm.nih.gov/3961002/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 3961002 |
3,961,029 | Effects of S-adenosyl-methionine on plasma norepinephrine, blood pressure, and heart rate in healthy volunteers. | Sherer M A MA, Cantoni G L GL, Golden R N RN, Rudorfer M V MV, Potter W Z WZ | Psychiatry research . Vol. 17, No. 2, 1986 Feb | S-adenosyl-methionine (SAMe) is currently undergoing trials as a possible antidepressant. Because SAMe's mechanism of action is obscure and norepinephrine (NE) is often implicated in affective disorders, we studied the effects of SAMe on this neurotransmitter in volunteers. Plasma NE and 3-methoxy-4-hydroxyphenylglycol... | https://pubmed.ncbi.nlm.nih.gov/3961029/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] | 3961029 |
3,961,308 | An intervention study among elderly people. Methodological and practical experiences. | Hendriksen C C | Scandinavian journal of primary health care . Vol. 4, No. 1, 1986 Feb | Based on a three years controlled intervention study among elderly subjects, aged 75 years or more and living in their own homes, the methodological and practical experiences achieved through interdisciplinary cooperation is described. The combination of social, medical and psychological interventions within the framew... | https://pubmed.ncbi.nlm.nih.gov/3961308/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3961308 |
3,961,633 | Effects of nifedipine on the peri-operative ECG, as determined by continuous Holter monitoring. A double-blind study. | du Toit H J HJ, Weich H F HF, Weymar H W HW, Przybojewski J Z JZ | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde . Vol. 69, No. 7, 1986 Mar 29 | A double-blind study was performed on 50 elderly patients undergoing hip-replacement surgery under general anaesthesia; 26 were given nifedipine and the remaining 24 placebo to determine effects on the continuously monitored (Holter) ECG during the 4 peri-operative days. Drugs were only administered during the latter 3... | https://pubmed.ncbi.nlm.nih.gov/3961633/ | [
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3961633 |
3,962,451 | In vitro production of anti-influenza virus antibody after simultaneous administration of H3N2 and H1N1 cold-adapted vaccines in seronegative children. | Edwards K M KM, Snyder P P, Thompson J M JM, Johnson P R PR, Wright P F PF | Vaccine . Vol. 4, No. 1, 1986 Mar | Sixteen doubly seronegative (H3N2 and H1N1) young children were recently enrolled in a study of live, attenuated cold-adapted influenza A vaccines. Twelve children received simultaneously H3N2 and H1N1 live, attenuated influenza vaccine intranasally and four received saline as placebo controls. Peripheral blood lymphoc... | https://pubmed.ncbi.nlm.nih.gov/3962451/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3962451 |
3,962,571 | Inaccuracy of peranesthetic gastric intubation for emptying liquid stomach contents. | Adelhøj B B, Petring O U OU, Hagelsten J O JO | Acta anaesthesiologica Scandinavica . Vol. 30, No. 1, 1986 Jan | To assess the accuracy of the method of peranesthetic gastric intubation for emptying the liquid stomach contents, this procedure was tried on 80 patients undergoing general anesthesia. Half of the patients had a double-barrelled 16F-Argyle Salem sump tube, length 120 cm, size 16 CH, and the other half had a single-bar... | https://pubmed.ncbi.nlm.nih.gov/3962571/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3962571 |
3,962,622 | The effect of polyvinylpyrrolidone-iodine as an disinfectant in eye surgery. | Klie F F, Bøge-Rasmussen I I, Jensen O L OL | Acta ophthalmologica . Vol. 64, No. 1, 1986 Feb | 105 patients admitted for cataract surgery were treated pre-operatively with polyvinylpyrrolidone-iodine (PVP-I) as a disinfectant, and consecutive bacterial cultures were obtained before initiating surgery and at the end of the operation. A control group (n = 99) only had a standard disinfection procedure of the eye (... | https://pubmed.ncbi.nlm.nih.gov/3962622/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] | 3962622 |
3,962,623 | Topical anaesthetic and tear film stability. | Mengher L S LS, Pandher K S KS, Bron A J AJ | Acta ophthalmologica . Vol. 64, No. 1, 1986 Feb | The effect of unpreserved topical anaesthetic on tear film stability (0.4% oxybuprocaine hydrochloride) was investigated in a double masked randomised study in 12 healthy volunteers, using a noninvasive tear film break up technique (NIBUT). It was found that the topical anaesthetic did not reduce the pre-corneal tear f... | https://pubmed.ncbi.nlm.nih.gov/3962623/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3962623 |
3,962,762 | Low-dose subcutaneous heparin in the prevention of deep-vein thrombosis and pulmonary emboli following acute stroke. | McCarthy S T ST, Turner J J | Age and ageing . Vol. 15, No. 2, 1986 Mar | Venous thrombo-embolism is a major and often unrecognized cause of morbidity and mortality in patients after acute strokes. Three hundred and five elderly patients were randomly allocated to either control (161) or treatment (144) with 5000 units calcium heparin subcutaneously 8-hourly for two weeks. A reduction in dee... | https://pubmed.ncbi.nlm.nih.gov/3962762/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3962762 |
3,963,017 | Flurbiprofen in the treatment of ankylosing spondylitis. A comparison with phenylbutazone. | Lomen P L PL, Turner L F LF, Lamborn K R KR, Brinn E L EL, Sattler L P LP | The American journal of medicine . Vol. 80, No. 3A, 1986 Mar 24 | Flurbiprofen (Ansaid, Upjohn), a potent new analgesic and anti-inflammatory agent, was compared with phenylbutazone in 90 patients with ankylosing spondylitis. In this double-blind, randomized, 26-week study, a total daily dose of 200 mg of flurbiprofen, administered three times daily, was as effective as 300 mg of phe... | https://pubmed.ncbi.nlm.nih.gov/3963017/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3963017 |
3,963,018 | Flurbiprofen in the treatment of ankylosing spondylitis. A comparison with indomethacin. | Lomen P L PL, Turner L F LF, Lamborn K R KR, Brinn E L EL | The American journal of medicine . Vol. 80, No. 3A, 1986 Mar 24 | In this randomized, double-blind study, 57 patients with ankylosing spondylitis were evaluated after 26 weeks of treatment with either flurbiprofen (Ansaid, Upjohn) or indomethacin. Flurbiprofen administered four times a day in a total daily dose of 200 mg was effective in controlling the pain and associated symptoms o... | https://pubmed.ncbi.nlm.nih.gov/3963018/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3963018 |
3,963,025 | Effects of flurbiprofen and aspirin on the gastric and duodenal mucosa. An endoscopic comparison. | Lanza F L FL, Royer G L GL, Nelson R S RS, Seckman C E CE, Schwartz J H JH, Rack M F MF, Gernaat C M CM | The American journal of medicine . Vol. 80, No. 3A, 1986 Mar 24 | A single-blind, randomized endoscopic tolerance study was conducted to compare daily doses of flurbiprofen (Ansaid, Upjohn) at 100, 150, and 200 mg per day with 2,600 mg of aspirin per day. Ten normal volunteers were enrolled in each of the flurbiprofen groups, and five were enrolled in the aspirin group. Analysis of t... | https://pubmed.ncbi.nlm.nih.gov/3963025/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] | 3963025 |
3,963,028 | Flurbiprofen in the treatment of rheumatoid arthritis. A comparison with aspirin. | Lomen P L PL, Turner L F LF, Lamborn K R KR, Brinn E L EL | The American journal of medicine . Vol. 80, No. 3A, 1986 Mar 24 | This large-scale, double-blind study compared 200 mg per day of flurbiprofen (Ansaid, Upjohn) with 4,000 mg per day of aspirin in 822 patients with definite or classical rheumatoid arthritis who were evaluated for up to 52 weeks. Overall response to therapy was similar in both groups. By the end of the study, however, ... | https://pubmed.ncbi.nlm.nih.gov/3963028/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3963028 |
3,963,030 | Treatment of osteoarthritis of the knee. A comparison of flurbiprofen and aspirin. | Lomen P L PL, Lamborn K R KR, Porter G H GH, Turner L F LF, Brinn E L EL | The American journal of medicine . Vol. 80, No. 3A, 1986 Mar 24 | The analgesic efficacy of flurbiprofen (Ansaid, Upjohn) and aspirin were compared in a 12-week, double-blind, randomized, parallel, multicenter study of 147 patients with osteoarthritis of the knee. Flurbiprofen (73 patients) was administered two, three, or four times a day in total daily doses of 100, 150, or 200 mg; ... | https://pubmed.ncbi.nlm.nih.gov/3963030/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3963030 |
3,963,031 | Effects of long-term administration of buspirone and diazepam on driver steering control. | Smiley A A, Moskowitz H H | The American journal of medicine . Vol. 80, No. 3B, 1986 Mar 31 | The effects of buspirone, diazepam, and placebo on tracking control were investigated over a nine-day period, using three groups of subjects, each with eight females and eight males. Subjects were tested using an interactive, computer-based driving simulator on days one, eight, and nine of the treatment period. On day ... | https://pubmed.ncbi.nlm.nih.gov/3963031/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] | 3963031 |
3,963,032 | Investigation of the abuse liability of buspirone in alcohol-dependent patients. | Griffith J D JD, Jasinski D R DR, Casten G P GP, McKinney G R GR | The American journal of medicine . Vol. 80, No. 3B, 1986 Mar 31 | By use of the Addiction Research Center Inventory, the Amphetamine Self-Rating Scale, the Single-Dose Questionnaire, and selected physiologic measures (blood pressure, pulse and respiratory rates, oral temperature, and pupil diameter), the abuse liability of buspirone (10, 20, and 40 mg) was compared with that of diaze... | https://pubmed.ncbi.nlm.nih.gov/3963032/ | [
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] | 3963032 |
3,963,039 | Effect of alcohol ingestion on breathing and oxygenation during sleep. Analysis of the influence of age and sex. | Block A J AJ, Hellard D W DW, Slayton P C PC | The American journal of medicine . Vol. 80, No. 4, 1986 Apr | Breathing and oxygenation were monitored in 78 asymptomatic volunteers on two successive nights of sleep. Four groups of subjects were recruited: 20 young men, 20 young women, 20 men older than 40 years, and 18 postmenopausal women. In random order, subjects ingested either 2 ml/kg (body weight) of 100-proof vodka in o... | https://pubmed.ncbi.nlm.nih.gov/3963039/ | [
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, Non-P.H.S."
] | 3963039 |
3,963,089 | Lactation suppression and puerperal fever. | Almeida O D OD, Kitay D Z DZ | American journal of obstetrics and gynecology . Vol. 154, No. 4, 1986 Apr | Seventy-five puerperal women who did not wish to breast-feed were treated with bromocriptine mesylate (Parlodel) or placebo in a prospective, randomized, double-blind study. Results revealed a puerperal fever incidence of 18.6%, 13.3% of which was due to breast engorgement and 5.3% to an infectious process. Parlodel pr... | https://pubmed.ncbi.nlm.nih.gov/3963089/ | [
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] | 3963089 |
End of preview. Expand in Data Studio
PubMed Medline
Overview
This dataset contains metadata and abstracts extracted from biomedical research publications indexed in PubMed (Date Accessed: 05/02/2025). The dataset is filtered to include only MEDLINE-indexed articles in the English language. Each record represents a single research publication with key metadata fields that provide insights into the article's content, authorship, and publication details.
Dataset Structure
Each record in the dataset represents a single PubMed article and contains the following fields:
- id: The unique identifier for the article (integer PubMed ID)
- pubmed_id: The PubMed ID as a string format (for compatibility with external systems)
- title: The full title of the research article
- authors: Comma-separated list of author names
- journal: Publication details including journal name, volume, issue, and publication date
- content: The article abstract text
- source_url: Direct link to the article on PubMed (format: https://pubmed.ncbi.nlm.nih.gov/{id}/)
- publication_types: Array of publication types (e.g., "Journal Article", "Review", "Clinical Trial")
Acknowledgements
We acknowledge the National Library of Medicine (NLM) for maintaining PubMed and making biomedical literature metadata accessible for research purposes.
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