query stringclasses 320
values | supports listlengths 5 64 | candidates listlengths 2 9 | answer stringclasses 100
values | id stringlengths 10 13 |
|---|---|---|---|---|
interacts_with DB04844? | [
"Agonists and antagonists for P2 receptors . Recent work has identified nucleotide agonists selective for P47900 , P41231 and Q15077 receptors and nucleotide antagonists selective for P47900 , Q9H244 and P51575 receptors . Selective non - nucleotide antagonists have been reported for P47900 , P41231 , Q15077 , Q9H2... | [
"___MASK100___",
"___MASK14___",
"___MASK25___",
"___MASK41___",
"___MASK50___",
"___MASK60___",
"___MASK63___",
"___MASK69___",
"___MASK82___"
] | ___MASK100___ | MH_train_1600 |
interacts_with DB00834? | [
"A new clinical evidence - based gene - environment interaction model of depression . In our current understanding of mood disorders , the role of genes is diverse including the mediation of the effects of provoking and protective factors . Different or partially overlapping gene sets play a major role in the devel... | [
"___MASK24___",
"___MASK40___",
"___MASK53___",
"___MASK56___",
"___MASK65___",
"___MASK67___",
"___MASK70___",
"___MASK91___",
"___MASK93___"
] | ___MASK40___ | MH_train_1601 |
interacts_with DB00215? | [
"Local control of alpha1 - proteinase inhibitor levels : regulation of alpha1 - proteinase inhibitor in the human cornea by growth factors and cytokines . Alpha 1 - proteinase inhibitor is a major serine proteinase inhibitor in the human cornea involved in the protection of the avascular corneal tissue against prot... | [
"___MASK16___",
"___MASK26___",
"___MASK37___",
"___MASK41___",
"___MASK48___",
"___MASK67___",
"___MASK76___",
"___MASK99___",
"___MASK9___"
] | ___MASK41___ | MH_train_1602 |
interacts_with DB06684? | [
"P09917 pathway promotes cell proliferation in human glioma cell lines . OBJECTIVE : P09917 ( P09917 ) is a key enzyme in the synthesis of leukotrienes ( LTs ) , that might promote carcinogenesis . We investigated P09917 expression and examined whether the P09917 pathway is associated with the proliferation of huma... | [
"___MASK12___",
"___MASK51___",
"___MASK52___",
"___MASK53___",
"___MASK57___",
"___MASK60___",
"___MASK64___",
"___MASK73___",
"___MASK84___"
] | ___MASK51___ | MH_train_1603 |
interacts_with DB00072? | [
"15 - Deoxy - delta ( 12 , 14 )- prostaglandin J ( 2 ) inhibits IL - 1beta - induced IKK enzymatic activity and P25963 degradation in rat chondrocytes through a PPARgamma - independent pathway . P37231 ( PPARgamma ) ligands have been shown to inhibit the effects of proinflammatory cytokines such as interleukin - 1b... | [
"___MASK23___",
"___MASK41___",
"___MASK50___",
"___MASK68___",
"___MASK73___",
"___MASK76___",
"___MASK83___",
"___MASK85___",
"___MASK95___"
] | ___MASK41___ | MH_train_1604 |
interacts_with DB06643? | [
"Expression of vitamin D receptor and 25 - hydroxyvitamin D3 - 1 { alpha }- hydroxylase in normal and malignant human colon . Considerable evidence exists to support the use of vitamin D to prevent and / or treat colorectal cancer . However , the routine use of bioactive vitamin D , 1 , 25 - dihydroxyvitamin D3 , i... | [
"___MASK18___",
"___MASK20___",
"___MASK25___",
"___MASK49___",
"___MASK72___",
"___MASK82___",
"___MASK87___",
"___MASK94___",
"___MASK95___"
] | ___MASK18___ | MH_train_1605 |
interacts_with DB00864? | [
"Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin . ___MASK79___ ( VP ) binds to the vasopressin type 2 receptor ( P30518 ) to trigger physiological effects including body fluid homeostasis and blood pressure regulation . Signaling is terminated by receptor downregulation involvi... | [
"___MASK100___",
"___MASK17___",
"___MASK23___",
"___MASK25___",
"___MASK27___",
"___MASK70___",
"___MASK79___",
"___MASK82___",
"___MASK86___"
] | ___MASK86___ | MH_train_1606 |
interacts_with DB00834? | [
"___MASK73___ in pediatric rheumatology : the clinical experience . During the last two decades , clinical use of novel biological therapy has led to increased mechanistic understanding of complex rheumatological diseases . Conversely , basic and translational studies have led to development of new and varied thera... | [
"___MASK2___",
"___MASK40___",
"___MASK54___",
"___MASK60___",
"___MASK66___",
"___MASK67___",
"___MASK73___",
"___MASK8___",
"___MASK9___"
] | ___MASK73___ | MH_train_1607 |
interacts_with DB00864? | [
"Nox2 and Nox4 mediate tumour necrosis factor - α - induced ventricular remodelling in mice . Reactive oxygen species ( ROS ) and pro - inflammatory cytokines are crucial in ventricular remodelling , such as inflammation - associated myocarditis . We previously reported that tumour necrosis factor - α ( P01375 - α ... | [
"___MASK11___",
"___MASK21___",
"___MASK25___",
"___MASK38___",
"___MASK3___",
"___MASK40___",
"___MASK56___",
"___MASK69___",
"___MASK8___"
] | ___MASK3___ | MH_train_1608 |
interacts_with DB01211? | [
"Recombinant human prothrombin kringles have potent anti - angiogenic activities and inhibit Lewis lung carcinoma tumor growth and metastases . P00734 , a protein involved in blood coagulation , is a plasma glycoprotein composed of the Gla domain , two adjacent kringle domains , and a serine protease domain . Kring... | [
"___MASK16___",
"___MASK24___",
"___MASK32___",
"___MASK39___",
"___MASK43___",
"___MASK45___",
"___MASK48___",
"___MASK49___",
"___MASK62___"
] | ___MASK16___ | MH_train_1609 |
interacts_with DB06643? | [
"β - cryptoxanthin regulates bone resorption related - cytokine production in human periodontal ligament cells . OBJECTIVE : β - cryptoxanthin ( β - cry ) is a type of carotenoid found in certain fruits and vegetables . Although it has been shown that β - cry inhibits alveolar bone resorption , the molecular mechan... | [
"___MASK100___",
"___MASK15___",
"___MASK16___",
"___MASK33___",
"___MASK39___",
"___MASK54___",
"___MASK63___",
"___MASK70___",
"___MASK95___"
] | ___MASK70___ | MH_train_1610 |
interacts_with DB00215? | [
"Calcineurin - inhibitor - free immunosuppression based on the JAK inhibitor CP - 690 , 550 : a pilot study in de novo kidney allograft recipients . This randomized , pilot study compared the Janus kinase inhibitor CP - 690 , 550 ( 15 mg P55957 [ CP15 ] and 30 mg P55957 [ CP30 ] , n = 20 each ) with tacrolimus ( n ... | [
"___MASK23___",
"___MASK46___",
"___MASK47___",
"___MASK52___",
"___MASK60___",
"___MASK68___",
"___MASK82___",
"___MASK84___",
"___MASK8___"
] | ___MASK82___ | MH_train_1611 |
interacts_with DB04844? | [
"P01308 - like growth factor - I treatment of children with Laron syndrome ( primary growth hormone insensitivity ) . Laron syndrome ( LS , congenital primary GH insensitivity ) is caused by deletions or mutations in the P10912 gene , resulting in an inability to generate insulin - like growth factor - I ( P05019 )... | [
"___MASK25___",
"___MASK29___",
"___MASK35___",
"___MASK36___",
"___MASK40___",
"___MASK48___",
"___MASK49___",
"___MASK57___",
"___MASK70___"
] | ___MASK29___ | MH_train_1612 |
interacts_with DB06643? | [
"Connexin 43 and P29323 regulate tension - induced signal transduction in human periodontal ligament fibroblasts . Periodontal ligament ( PDL ) fibroblasts play an important role in preserving periodontal homeostasis and transmitting mechanical signals to alveolar bone . Connexin 43 ( P17302 ) , a gap junction prot... | [
"___MASK17___",
"___MASK18___",
"___MASK3___",
"___MASK40___",
"___MASK42___",
"___MASK45___",
"___MASK59___",
"___MASK70___",
"___MASK95___"
] | ___MASK42___ | MH_train_1613 |
interacts_with DB01211? | [
"Traumatic brain injury - induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis . Proper CNS function depends on concerted expression of thousands of genes in a controlled and timely manner . Traumatic brain injury ( TBI ) in mammals results in neuronal death and neurological ... | [
"___MASK10___",
"___MASK23___",
"___MASK32___",
"___MASK43___",
"___MASK69___",
"___MASK79___",
"___MASK80___",
"___MASK81___",
"___MASK92___"
] | ___MASK43___ | MH_train_1614 |
interacts_with DB00834? | [
"Agonism at P41595 receptors is not a class effect of the ergolines . Restrictive cardiac valvulopathies observed in Parkinson patients treated with the ergoline dopamine agonist pergolide have recently been associated with the agonist efficacy of the drug at 5 - hydroxytryptamine2B ( P41595 ) receptors . To evalua... | [
"___MASK14___",
"___MASK21___",
"___MASK30___",
"___MASK41___",
"___MASK63___",
"___MASK73___",
"___MASK77___",
"___MASK83___",
"___MASK97___"
] | ___MASK41___ | MH_train_1615 |
interacts_with DB00864? | [
"beta - Carotene induces apoptosis and up - regulates peroxisome proliferator - activated receptor gamma expression and reactive oxygen species production in MCF - 7 cancer cells . Although the pharmacological role of beta - carotene in the prevention and treatment of many cancer cells has received increasing atten... | [
"___MASK14___",
"___MASK21___",
"___MASK23___",
"___MASK43___",
"___MASK54___",
"___MASK74___",
"___MASK93___",
"___MASK94___",
"___MASK97___"
] | ___MASK54___ | MH_train_1616 |
interacts_with DB00215? | [
"Whole blood lead concentration and erythrocyte delta - aminolevulinic acid dehydratase ( P13716 ) activity in selected canine populations in Greece . In a total number of 275 dogs of various ages , sex and breed , blood lead concentrations ( O43927 ) and erythrocyte P13716 activity were measured . Sixty - six of t... | [
"___MASK100___",
"___MASK38___",
"___MASK4___",
"___MASK58___",
"___MASK65___",
"___MASK6___",
"___MASK73___",
"___MASK77___",
"___MASK91___"
] | ___MASK73___ | MH_train_1617 |
interacts_with DB01211? | [
"DB00227 - stimulated superinduction of P16581 , P05362 and P19320 in P01375 activated human vascular endothelial cells . Inhibitors of P04035 ( statins ) reveal important pharmacological effects in addition to reducing the plasma LDL cholesterol level . In the pathogenesis of arteriosclerosis , transendothelial mi... | [
"___MASK15___",
"___MASK28___",
"___MASK3___",
"___MASK43___",
"___MASK49___",
"___MASK52___",
"___MASK81___",
"___MASK84___",
"___MASK93___"
] | ___MASK52___ | MH_train_1618 |
interacts_with DB01211? | [
"Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope - dilution LC - MS / MS : first evidence of DNA methylation in Caenorhabditis elegans . From 1986 to the present , the popular research model organism Caenorhabditis elegans has been thought to completely lack DNA methylation and seems ... | [
"___MASK19___",
"___MASK33___",
"___MASK34___",
"___MASK37___",
"___MASK54___",
"___MASK59___",
"___MASK67___",
"___MASK71___",
"___MASK96___"
] | ___MASK96___ | MH_train_1619 |
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