pmid stringlengths 8 8 | title stringlengths 9 343 | abstract stringlengths 10 6.95k | pub_date stringdate 2022-01-01 00:00:00 2026-04-01 00:00:00 |
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41163695 | Clinical and Demographic Correlates of Pornography Addiction: A Cross-sectional Study from India. | Pornography addiction is a growing public health concern worldwide, with increasing recognition of its prevalence and consequences in India. This study explores the onset, manifestation, and impact of pornography addiction within the Indian context, addressing the need for culturally relevant research. A retrospective,... | 2025-10-26 |
41165541 | Wellness Curriculum to Promote Resilience. | Burnout as a public health crisis has gained attention in recent years. Integrating a wellness curriculum into training programs can reduce burnout and cultivate the awareness and skills needed to support a sustainable career in health care. The faculty midwives within the residency program in obstetrics and gynecology... | 2025-10-30 |
41197969 | Burden Beyond the Bedside: A Global Synthesis of Depression in Informal Cancer Caregivers: An Umbrella Review. | The aim of this umbrella review is to synthesize pooled prevalence of existing evidence on depressive morbidity among informal cancer caregivers. This umbrella review was conducted in accordance with PRISMA guidelines, and the protocol was registered in PROSPERO (CRD420251032522). A comprehensive search of major databa... | 2025-11-04 |
41198258 | Pulmonary Disease in the Older Adult: A Review of Interstitial Lung Disease. | Interstitial lung diseases (ILDs) are a group of diverse conditions of critical importance to the care of the older adult that can cause pulmonary fibrosis, respiratory failure, and death. Aging and geriatric principles are key factors in the epidemiology, pathogenesis, and management of ILD. Effective management of IL... | 2025-11-01 |
41197662 | Impact of liver cirrhosis on postoperative outcomes following total hip and knee arthroplasty : a systematic review and meta-analysis. | Cirrhosis is a known comorbidity that may influence outcomes following total joint replacement (TJR). This meta-analysis evaluates the impact of cirrhosis on postoperative complications and mortality after TJR. A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. Four databases wer... | 2025-11-07 |
41190951 | CCD2MD: A Suite of Packages for Preparing Co-Folded Outputs for Molecular Dynamics Simulations. | Protein-lipid interactions play a crucial role in the stability and function of membrane proteins. While experimental approaches to characterize these interactions in a native-like membrane environment can be challenging, computational techniques offer a powerful alternative for identifying and analyzing potential bind... | 2025-11-05 |
41175797 | Computed tomography (CT) structured reporting generation based on the intelligent assisted diagnosis system for rectal cancer staging and evaluation of its clinical application. | To evaluate the clinical utility of the intelligent assisted diagnosis system for rectal cancer staging (IADS-R) in aiding radiologists of varying levels of experience to produce computed tomography (CT) structured reporting (SR). Six hundred fifty abdominal enhanced CT datasets from rectal cancer patients were collect... | 2025-10-06 |
41165208 | An optimized, high-throughput workflow for the collection, processing, and visualization of histology data in comparative vertebrate morphogenesis. | In an era where the diversity and quality of imaging modalities is rapidly increasing, it may seem counterintuitive to promote classical histology as a critical skill. It is a mistake, however, to assume that the heuristic potential of these high-resolution histological data is stagnant. Deep learning algorithms have e... | 2025-10-30 |
41187392 | Antineoplastic and antibacterial activity of new copper(II) complexes with H₂salbu and H₄salbu Schiff base-type ligands. | This study explores the structural, electronic, and biological properties of ten copper(II) complexes with Schiff bases (N,N'-bis(5,5'-R-salicylidene)-1,4-butanediamine)) ([Cu<sub>2</sub>(MeO-L1)<sub>2</sub>], [Cu<sub>2</sub>(Me-L2)<sub>2</sub>], [Cu(H-L3)], [Cu(Cl-L4)] and [Cu(NO<sub>2</sub>-L5)]), and their hydrogena... | 2025-10-24 |
41201708 | Evaluation of coronary artery calcium score by age and sex: a multicenter study. | To evaluate coronary artery calcium (CAC) scores in a large Turkish cohort using age- and sex-specific percentiles, and to assess the agreement between CAD-RADS plaque burden scores and percentile-based CAC classification. A total of 4,887 clinically referred patients who underwent coronary CT angiography (CCTA) with n... | 2025-11-07 |
41173334 | Streamlined construction of episomal vectors for rapid assessment of fusion phytase display in Saccharomyces cerevisiae. | We developed a fusion phytase combining acid- and alkaline-active phytases, displayed on Saccharomyces cerevisiae cells. Recombinant replicative vectors were constructed to harbor phytase expression cassettes, enabling rapid screening of fusion enzyme constructs. This system provides a preliminary approach for optimizi... | 2025-10-29 |
41173039 | Centralization for reducing medial meniscal extrusion after root tear repair appears effective but is technique-dependent : a systematic review. | The aim of this systematic review was to examine whether meniscal centralization techniques, including posteromedial suture anchor (PMA) and posteromedial transtibial pullout repair (PMP), when added to conventional medial meniscus root repair, could affect the outcomes. A systematic search was conducted in four electr... | 2025-11-01 |
41166858 | Predicting oxcarbazepine-induced hyponatremia in adult epilepsy patients: A multicenter machine learning analysis using real-world CDM data. | Oxcarbazepine (OXC) is a widely used antiseizure medication (ASM) associated with hyponatremia. This study aimed to assess the prevalence and risk factors for OXC-induced severe hyponatremia using machine learning (ML) models applied to multicenter real-world data standardized within the Observational Medical Outcomes ... | 2025-10-16 |
41174088 | Improving timing of early neonatal hypoglycemia screening in the well-baby nursery. | Neonatal hypoglycemia can impair neurodevelopment. Timely glucose screening, aligned with AAP guidelines, may enable prompt detection of hypoglycemia. This initiative, conducted from November 2021 to April 2023, aimed to improve the timing of screening without negatively impacting breastfeeding. Key drivers included ti... | 2025-10-31 |
41199315 | Berberine and berberrubine promote the expression of CYP3A4 via enhancing the binding of nuclear receptor PXR. | Berberine is currently co-administered with statins in clinical practice for hyperlipidemia management. This study aimed to investigate the effects of berberine and berberrubine on CYP3A4 expression and the regulatory mechanism. Using rifampicin as a positive control group, HepG2 cells were treated with different conce... | 2025-11-06 |
41191359 | Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study. | Age-related hearing loss is a potentially modifiable risk factor for cognitive impairment and dementia. To investigate the association of hearing loss with brain structure changes, cognitive function, and incident dementia. This cohort study included Framingham Heart Study Offspring Study participants attending their s... | 2025-11-03 |
41208775 | Modular Synthesis of Diverse <i>gem</i>-Difluoroalkenes from Trifluoroacetic Anhydride via Phosphorus-Assisted Fluoride Elimination. | Here we report a modular strategy for constructing structurally diverse <i>gem</i>-difluoroalkenes via phosphorus-assisted fluoride elimination using trifluoroacetic anhydride as the fluorine source. The protocol provides access to fully substituted architectures with unprecedented generality across alkyl, aryl, alkeny... | 2025-11-10 |
41168084 | Lysine demethylase 4A: from chromatin to centrosomes. | The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome. KDM4A interacts with centrosome proteins, and its l... | 2025-10-30 |
41184967 | Targeted test evaluation: five suggestions for refining the framework for designing diagnostic accuracy studies with clear study hypotheses. | Five years ago, Korevaar and colleagues proposed a framework for designing diagnostic accuracy studies, focusing on the definition of clear study hypotheses. This proposal filled a gap and was well received by the scientific community. In this commentary, I suggest five potential refinements. They aim at increasing the... | 2025-11-04 |
41207044 | A coumarin-benzothiazole probe-driven multimodal aptasensing platform for label-free analysis and portable visualization of kanamycin in milks. | Kanamycin (KANA) is an aminoglycoside antibiotic that widely adopted in foods safety and the excessive intake can cause various symptoms. Although conventional methods for KANA detection have been well-developed, they still remain challenges in real scenarios application. We here report a coumarin-benzothiazole probe a... | 2025-11-07 |
41180176 | Elevated pre-pregnancy testosterone is associated with gestational diabetes mellitus: an observational cohort study. | Pre-pregnancy testosterone increase may be closely related to the occurrence of gestational diabetes mellitus (GDM). Our aim is to explain the relationship between pre-pregnancy testosterone levels and the risk of GDM and provide evidence for early clinical warning. We conducted a retrospective cohort study on 4174 par... | 2025-01-01 |
41193350 | [Costs of informal caregiving for people with cognitive impairment: A cost study based on the Digital Dementia Registry Bavaria (digiDEM Bayern)]. | Informal care costs account for the largest share of the total costs of dementia. The informal care costs of dementia have been well researched in Germany, but the group of family caregivers of people with MCI ("mild cognitive impairment") has not been taken into account so far. The aim of this study is the evaluation ... | 2025-11-04 |
41170807 | Maternal and neonatal outcomes of ultrasound-guided percutaneous nephrostomy for symptomatic hydronephrosis in pregnancy: a retrospective cohort study. | To evaluate the maternal and neonatal outcomes of pregnant patients who underwent ultrasound-guided percutaneous nephrostomy for the management of symptomatic hydronephrosis. This retrospective cohort study evaluated 85 pregnant patients with symptomatic hydronephrosis (≥ Grade 2) managed at a tertiary center between J... | 2025-11-03 |
41179665 | Concurrent esophageal squamous cell carcinoma with gastric mucosa-associated lymphoid tissue lymphoma: a case report. | Double primary malignant tumors are infrequently encountered, with esophageal squamous cell carcinoma (ESCC) co-occurring with malignancies in other organs, representing a rare clinical entity. The concomitant presence of ESCC and lymphoma is even more uncommon, posing substantial diagnostic and therapeutic challenges.... | 2025-01-01 |
41185107 | EBV-associated Vulvar Ulcer Following Receptive Oral Sex in an Adolescent: A Case Suggesting Possible Sexual Transmission. | We report a case of Epstein-Barr virus (EBV)-associated vulvar ulcer in a 17-year-old girl, with EBV DNA confirmed by polymerase chain reaction (PCR) in both blood and ulcer swab. A history of receptive orogenital exposure raises the possibility of local viral inoculation. This case highlights the value of EBV testing ... | 2025-11-04 |
41183572 | mRNA nanomedicine reprograms the cell cycle to increase the effectiveness of targeted therapy for HER2-low breast cancers. | Over 70 % of breast cancer patients present with tumors exhibiting low or undetectable HER2 expression, making them largely unresponsive to current HER2-targeted therapies. To address this, we developed an innovative lipid nanoparticle (LNP)-based mRNA nanomedicine that reprograms tumor cell cycle by restoring expressi... | 2025-11-01 |
41211727 | Reactivity of Nanoconfined Water Is Modulated by the Properties of Confining Materials. | The autoionization of water, a fundamental process in aqueous chemistry, is profoundly altered under nanoconfinement. The properties of the confining material determine the layer dependence of autoionization, dictating whether reactions are stabilized at the interface or in the subsurface. Under weak water-wall interac... | 2025-11-10 |
41194049 | Surgical outcomes of Ahmed valve implantation with mitomycin C in glaucoma with and without high myopia. | This study aimed to assess the surgical outcomes of Ahmed glaucoma valve (AGV) implantation in high myopic eyes (axial length [AL] of ≥ 26.0 mm) and to determine whether high myopia independently poses a risk of surgical failure. We retrospectively reviewed 68 eyes from 59 patients with refractory glaucoma who underwen... | 2025-11-05 |
41178751 | TGFβ Participation in the Remyelination Process Through Microglial Modulation and Oligodendrocyte Maturation. | Central nervous system (CNS) diseases occur in the context of inflammation and demyelination. Demyelination is a pathological process in which myelin sheaths are lost from around axons, while remyelination is the restoration of myelin sheaths by oligodendrocytes. TGFβ is an anti-inflammatory cytokine that participates ... | 2025-01-01 |
41200631 | The Significance of Emergency Surgical Operations for Severe Elderly Patients Considering Medical Costs and Activities of Daily Life. | Purpose The global population is aging rapidly, and physicians increasingly face challenges in determining the appropriateness of emergency surgery for elderly patients. This study aimed to evaluate the clinical significance of emergency operations in elderly patients. Methods This retrospective clinical study include... | 2025-10-01 |
41173734 | Seeing More, Treating Smarter: Role of Long-axial Field-of-view PET/Computed Tomography in the Evolution of Theranostics. | Long-axial field-of-view (LAFOV) PET/computed tomography has the potential to redefine the role of molecular imaging in theranostics by making multiparametric whole-body imaging and predictive dosimetry more clinically feasible. Compared to conventional PET systems, LAFOV scanners provide dramatic gains in sensitivity ... | 2025-10-30 |
41174827 | Next-generation specimen digitization: capturing reflectance spectra from the world's herbaria for modeling plant biology across time, space, and taxa. | Spectral reflectance measured from herbarium specimens represents a potentially vast source of information relevant to plant taxon identification and functional traits, which has inspired many laboratories world-wide to initiate next-generation spectral digitization from specimens. Combining these datasets into a coord... | 2025-10-31 |
41172029 | [Not Available]. | Introducción: La depresión es el principal trastorno mental en América Latina. Su etiología es multifactorial, abarcando desde factores genéticos, sociodemográficos, culturales e incluso ambientales. Se ha evidenciado en algunos estudios que el vivir en regiones de gran altitud puede estar relacionado con la depresión.... | 2025-10-10 |
41203090 | Impact of microplastics and nanoplastics on human health: Mechanistic insights and exposure pathways. | Microplastics (MPs) and nanoplastics (NPs) have emerged as critical environmental contaminants with potential adverse effects on human health. This review examines the various ways MPs and NPs can be spread in the environment and their potential impact on humans. They can be introduced into the environment through mult... | 2025-11-05 |
41202742 | Global recreational consumption of non-native inland fish: higher economic benefits, but lower nutritional value and climate resilience. | Inland recreational fisheries are globally significant leisure pursuits, with well-documented benefits to human health and well-being, but also one of the principal drivers of non-native fish introductions to enhance fishing opportunities, whether for sport or sustenance. In this study, we assess the relative reliance ... | 2025-11-06 |
41176604 | The influence of incorporation of hydroxyapatite/collagen nanocomposite into glass ionomer cement on surface roughness, microhardness, and fluoride-ion release potential. | To investigate the effect of incorporation of 5 and 10 weight% of hydroxyapatite /collagen (HA/Col) nanocomposite with different ratios (50:50) and (70:30) to conventional glass ionomer cement (C-GIC) on surface roughness, microhardness, and fluoride-ion release. Seventy-five specimens were prepared using split Teflon ... | 2025-11-01 |
41164613 | Influence of Polishing Systems on Surface Roughness of Lithium Disilicate Ceramics Following Dental Bleaching. | The alteration of surface texture of lithium disilicate materials through the application of carbamide peroxide gels, which are frequently utilized as home bleaching agents, presents significant implications that remain contentious, and the enhancement of this phenomenon via polishing techniques is additionally subject... | 2025-09-01 |
41196708 | How digital reading habits shape reading motivation and comprehension over time: Longitudinal associations in primary school. | Nowadays, children's reading habits extend beyond traditional printed texts, embracing new practices and forms through digital devices. The influence of such new digital reading habits on reading motivation and comprehension development remains largely underexplored. This study aimed to explore reciprocal causal paths ... | 2025-11-06 |
41211684 | Reducing internalized HIV stigma with Intervention Mapping: the design, implementation, and evaluation of RESET (RESilience and Empowerment Training). | HIV is a highly stigmatized condition, and negative beliefs about HIV and people with HIV are frequently internalized. This paper describes how we designed, implemented, and evaluated RESET, an intervention aiming to reduce internalized HIV stigma among people with HIV in the Netherlands. This face-to-face, three-sessi... | 2025-11-10 |
41210678 | Aneurysmal Coronary Artery Disease: A Contemporary and Comprehensive Review. | Coronary artery aneurysm (CAA) is a focal enlargement of the coronary artery exceeding 1.5 times the diameter of the adjacent normal segment of the vessel. The reported prevalence of CAA varies widely from 0.2 to 10%, with male predominance and a predilection for the right coronary artery. Atherosclerosis is the main c... | 2025-12-01 |
41187863 | Correlates of antibiotic use in U.S. adults: An analysis of medical expenditure panel survey data, 2017-2022. | To identify sociodemographic and health-related correlates of antibiotic use in U.S. adults and determine whether racial/ethnic and regional disparities persisted throughout and after the COVID-19 pandemic. Using data from the Medical Expenditure Panel Survey (2017-2022) for 118,110 U.S. adults aged 18 years or older, ... | 2025-11-02 |
41188976 | Engineering hypoimmune stem cell-derived beta cells. | In type 1 diabetes (T1D), autoimmune targeting destroys insulin-producing β cells in the pancreas, creating a chronic state of insulin deficiency. Islet transplantation presents a regenerative cell therapy approach that can re-establish insulin production and intrinsic glycemic control. However, islet transplantation i... | 2025-11-04 |
41197372 | Decadal changes in California's temperate mesophotic reef invertebrate community through the 2014-2016 northeast Pacific marine heatwave. | The 2014-2016 northeast Pacific marine heatwave (MHW) disrupted marine ecosystems in California, with well-documented impacts on kelp reef ecosystems, and deep reef fish assemblages. However, no studies have assessed the direct or indirect impacts on sessile benthic reef invertebrates inhabiting mesophotic rocky reefs ... | 2025-10-22 |
41165237 | TRPC6 effects on albumin permeation, nephrin shedding, and apoptosis in podocytes: Role of calcineurin and metalloproteases. | The effects of TRPC6 activation for various periods of time on three classes of functional outputs were examined in cultured podocytes: albumin permeation across a confluent layer; changes in nephrin dynamics; and cell death. Albumin permeation in transwell assays was significantly increased within 1 h in response to t... | 2025-11-01 |
41176318 | Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. | Cannabis consumption has increased among young adults, but its long-term cardiovascular impact remains unclear. This study assessed the association between cannabis use at admission for acute coronary syndrome (ACS) and long-term prognosis. A retrospective, single-centre cohort included patients under the age of 45 yea... | 2025-10-31 |
41182345 | Effect of renal denervation on the lipid profile in patients with or without coronary artery disease. | Sympathetic overactivation plays a critical role in the pathophysiology of various conditions, such as arterial hypertension, chronic kidney disease, coronary artery disease (CAD), diabetes, metabolic syndrome, and dyslipidemia. Initially developed for hypertension management, renal denervation (RDN) has also been asso... | 2025-11-03 |
41173959 | From performance to prediction: extracting aging data from the effects of base load aging on washing machines for a machine learning model. | The standard testing of washing machine performance faces reliability challenges, which stem from the uncontrollable degradation of base load. This study provided a quantified standard for base load age to enhance the reliability and stability of the washing machine performance testing process. First, the impact of bas... | 2025-10-31 |
41166697 | In Vitro Characterization of the Aromatic SAM-Dependent C-Methyltransferase NapB5. | Aromatic polyketide synthase (PKS) products undergo diverse tailoring reactions in the biosynthesis of natural products. <i>S</i>-Adenosyl-l-methionine (SAM)-dependent C-methyltransferases (C-MTs) play a key role in this diversification. In the biosynthesis of napyradiomycins, the C-MT NapB5 from <i>Streptomyces aculeo... | 2025-10-30 |
41208783 | Dual-Mode Thermal Response of Visible/NIR Emission in Er<sup>3+</sup>-Doped Layered Perovskite via Modulating Thermally Induced Oxygen Vacancies and Cross Relaxation. | Overcoming thermal quenching remains a pivotal challenge for the practical application of upconversion luminescence (UCL) materials. Herein, a novel UCL material based on Er<sup>3+</sup>-doped layered perovskite oxyhalide Bi<sub>4</sub>Ti<sub>0.5</sub>W<sub>0.5</sub>O<sub>8</sub>Cl is demonstrated to exhibit a unique d... | 2025-11-10 |
41201191 | Effective spot size parameters for Acuros dose calculation algorithm using enhanced leaf modelling: Estimation based on small rectangular MLC fields. | Small field dosimetry plays a critical role in stereotactic radiotherapy, particularly for elongated fields shaped by multileaf collimators (MLCs). This study aims to optimize the Effective Spot Size (ESS) parameters in the Acuros dose calculation algorithm (Eclipse v18.0, with the enhanced leaf modelling ELM for MLC m... | 2025-11-01 |
41194690 | Effects of Three Different Ureteral Stents on Stent-Related Symptoms in Patients Undergoing Ureteroscopic Lithotripsy: Assessment Using the Ureteral Stent Symptoms Questionnaire. | <b><i>Objective:</i></b> Ureteral stents are commonly used after ureteroscopic lithotripsy (URS) to prevent obstruction, but often cause stent-related symptoms (SRS), which can impact patients' quality of life. The Ureteral Stent Symptoms Questionnaire (USSQ) is a validated tool for assessing these symptoms. This study... | 2025-10-31 |
41210115 | Protective effects of <i>Lactobacillus casei</i> and <i>Chlorella vulgaris</i> on cardiac gene expression (<i>NF-κB</i>, <i>Nrf-2</i>) and structural alterations in a <i>C57BL/6</i> mouse model of MASLD. | Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most frequent chronic liver disease. The literature strongly links MASLD to increased epicardial fat thickness, left ventricular hypertrophy, and valvular calcifications. The effects of <i>Lactobacillus casei</i> and <i>Chlorella vulgaris</i> micro... | 2025-12-01 |
41185454 | Platelets During Myelin Repair in Multiple Sclerosis: Friend or Foe? | Multiple sclerosis (MS) is an autoimmune neuroinflammatory demyelinating disease of the central nervous system (CNS) that affects more than 2.5 million people worldwide. Remyelination represents a robust regenerative response to myelin damage; however, during the later stages of MS, this process largely fails. Upon dem... | 2025-11-01 |
41208180 | Efficiency Recalibrates Social-Emotional Trade-Offs Behind Partner Choice in Direct Reciprocity through Intention-Specific Neural Bases. | Direct reciprocity, in which beneficiaries return favors to benefactors, is a cornerstone of human cooperation. Previous empirical work addresses partner control-how individuals decide whether and how much to reciprocate-whereas the equally critical dimension of partner choice, deciding whom to reciprocate when aided b... | 2025-11-09 |
41176686 | Expansion of Variant Panels in Newborn Screening Algorithms to Identify Cystic Fibrosis: A Retrospective Analysis of 25 Years of Genotypes and Implications on Diagnosis. | We seek to understand the incremental value of applying expanded variant panels or sequencing in population-based screening algorithms for a well-understood condition like cystic fibrosis (CF). We compared newborn screening methods to determine at what point do attempts to increase sensitivity of second-tier testing me... | 2025-10-30 |
41182795 | Categorizing tasks around a break reduces rumination and improves task performance. | People often take short breaks from goal-related activities (e.g., at work, during exercise) to stay motivated and prevent burnout. The current research examines a novel factor influencing break effectiveness: task categorization. We suggest that the way people construe tasks around breaks influences their rumination a... | 2025-11-03 |
41195892 | Gradient Hydrogel Electrolyte Enables High Ionic Conductivity and Robust Mechanical Properties for Dendrite-Free Aqueous Zinc-Ion Battery. | Rechargeable aqueous Zinc-ion batteries (AZIBs) hold great promise for sustainable storage, yet their practical deployment is impeded by dendrite growth and hydrogen evolution reaction (HER). Hydrogel electrolytes offer a potential solution to stabilization but suffer from a trade-off in ionic conductivity and mechanic... | 2025-11-06 |
41200297 | Protective effect of capsaicin on AKT1 and MAPK1 expression in the liver of mice (<i>Mus musculus</i>) induced by aflatoxin B1. | The metabolism of toxins after ingestion by animals involves transformation into various metabolites with different levels of toxicity. Aflatoxin B1 undergoes biotransformation into various compounds in the mitochondria that are closely related to its toxic effects. <i>Capsicum annuum</i> L. or chili is a plant that pr... | 2025-09-01 |
41181140 | Retraction: Mast cells in skin scarring: a review of animal and human research. | [This retracts the article DOI: 10.3389/fimmu.2020.552205.]. | 2025-01-01 |
41168049 | Remnant cholesterol and associations with incidence, progression, and change in coronary artery calcium in South Asian Americans. | Remnant cholesterol (RC) may contribute to residual risk of atherosclerotic cardiovascular disease (ASCVD), but few studies have examined this in South Asian populations, who experience a disproportionately high incidence of ASCVD. Using data from the Mediators of Atherosclerosis in South Asians Living in America (MASA... | 2025-10-28 |
41172645 | Production, crystallographic studies, and functional profiling of γ-carbonic anhydrase from the probiotic Limosilactobacillus reuteri: In vitro and cell-based insights. | Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a probiotic bacterium involved in maintaining gut microbiota balance and modulating immune response. In this study, for the first time, we report the recombinant production and kinetic characterization of its γ-class carbonic anhydrase (CA, EC 4.2.1.1), re... | 2025-10-25 |
41189685 | Therapeutic potential of natural polymer-based transdermal drug delivery system for musculoskeletal disorders. | The transdermal drug delivery system is a highly safe and well-tolerated therapeutic approach with significant potential for treating musculoskeletal disorders. However, its clinical application is limited by the low skin permeability of many active drugs in its formulations. To overcome this challenge, advancements in... | 2025-01-01 |
41183181 | Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. | Patients with intermediate-high risk pulmonary embolism (PE) have an elevated right-to-left-ventricular (RV/LV) diameter ratio and are at risk of early clinical decompensation and mortality. Reperfusion therapy aims to rapidly relieve acute RV pressure overload and normalize hemodynamics. STORM-PE is the first reported... | 2025-11-03 |
41181722 | Safety of Sodium Zirconium Cyclosilicate in Critically Ill Patients With Impaired Gastric Motility: A Case of Persistent Intragastric Precipitation. | Sodium zirconium cyclosilicate (SZC) is a novel potassium-binding agent used to treat hyperkalemia. Although SZC is generally considered safe, its efficacy and safety in critically ill patients remain unclear. We report a novel adverse event of persistent intragastric SZC precipitation in a critically ill patient. A ma... | 2025-10-01 |
41172768 | Influence of resin structure on the prediction of two-component protein adsorption behavior in anion exchange resins from single component batch data. | Understanding the adsorption equilibria and kinetics of multicomponent mixtures is essential to developing and modeling separation processes. In our previous research, we demonstrated the significant impact of resin structure on the efficiency with which two components are separated in frontal chromatography. This stud... | 2025-10-24 |
41177558 | Neonatal glucose-6-phosphate dehydrogenase activity by gestational age and sex: evidence-based cut-offs for newborn screening in Saudi Arabia. | To characterise quantitative glucose-6-phosphate dehydrogenase (G6PD) activity in term and preterm neonates, compare activity by gestational age (GA) and sex and derive neonatal screening cut-offs using percentile and WHO methods. Retrospective cross-sectional analysis of cord blood screening programme. King Abdulaziz ... | 2025-11-02 |
41162403 | Microbiome and well-being: a meta-analysis. | The human microbiome may play a significant role in both health and disease. However, most studies to date have focused on the microbiome's role in pathogenesis, while its potential role in promoting well-being remains underexplored. We conducted the first meta-analysis synthesizing empirical evidence on associations b... | 2025-10-29 |
41172118 | Families' and therapists' experience of a telehealth programme for children and adolescents with cerebral palsy during the COVID-19 pandemic. | To understand how families and therapists perceived their participation in an individualized home telehealth programme implemented for children and adolescents with cerebral palsy (CP) during the COVID-19 pandemic in Brazil. This was a descriptive qualitative study that included 13 families of children and adolescents ... | 2025-10-31 |
41184865 | Risk stratification and healthcare disparities in COVID-19 outcomes: a retrospective cohort study of treatment pathways before and after infection. | COVID-19 infections continue globally post-pandemic. Analyzing treatment pathways and clinical outcomes remains essential for understanding prognostic factors. We reviewed medical records of COVID-19-positive outpatients and inpatients from Wenling Hospital of Traditional Chinese Medicine (January 2022-April 2024). Log... | 2025-11-03 |
41172526 | Population ecology of bivalve mollusks in beach sediments on the southern coast of Espírito Santo, Brazil. | This study examined the population ecology of bivalve mollusks on Central Beach in Piúma, southern Espírito Santo, Brazil, over one year (August 2018 to July 2019). Sampling was conducted along four transects perpendicular to the shoreline, with sediment characteristics and benthic community structure analyses. 2,104 i... | 2025-01-01 |
41191615 | Brain volumetric reductions in patients with thrombotic thrombocytopenic purpura. | Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disorder caused by a deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13). The recognition of increased morbidity and mortality in patients after recovery suggests that TTP may become a chronic disease ... | 2025-01-01 |
41171134 | gcMeta 2025: a global repository of metagenome-assembled genomes enabling cross-ecosystem microbial discovery and function research. | The rapid growth of metagenomic sequencing has generated an unprecedented wealth of metagenome-assembled genomes (MAGs), transforming opportunities for microbial discovery and functional characterization. Yet, full utilization of these resources has been constrained by heterogeneous data generation practices and incons... | 2025-10-31 |
41189699 | Overview of approved COVID-19 vaccines in the EU, recommendations for use in Sweden and vaccine uptake over time: Report from the Swedish Medical Products Agency and the Public Health Agency of Sweden. | The aim of this review is to describe the regulatory background of the COVID-19 vaccines, the national recommendations for use issued and vaccine uptake in Sweden. It includes an overview of licensing and relevant safety aspects identified by the European Medicines Agency (EMA) and the national vaccination plan issued ... | 2025-01-01 |
41197483 | Estimating the causal impact of the Paris agreement on the ESG market: A Bayesian structural time-series approach. | This study uses a Bayesian structural time-series model to examine the causal impact of the Paris Agreement on Environmental, Social, and Governance (ESG) markets across 18 countries. The research addresses key gaps in understanding the long-term effects of international climate agreements on sustainable finance. By an... | 2025-11-05 |
41185814 | Adiponectin Paradox in Coronary Artery Bypass Graft Patients: A Comparative Analysis of Pericardial Fluid and Plasma Levels. | Background Adiponectin is an anti-inflammatory and cardioprotective adipokine involved in the regulation of glucose and lipid metabolism. Although it has been extensively studied in blood, data on its concentrations in pericardial fluid remain scarce. Objectives This study aimed to assess adiponectin levels in plasma a... | 2025-10-01 |
41202890 | Prevalence and clinical impact of baseline atherosclerotic vascular disease in patients undergoing transcatheter aortic valve implantation: A meta-analysis. | Degenerative aortic valve disease and atherosclerotic vascular disease (ASCVD) frequently coexist. ASCVD may impact pre-procedural planning and patient outcomes. To systematically quantify the prevalence and prognostic significance of prior coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovasc... | 2025-11-05 |
41182510 | Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats. | For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models. These findings have given rise to a longstanding, y... | 2025-11-03 |
41198283 | Validation of the use of ToF-SIMS for analysis of glycosaminoglycans. | Glycosaminoglycans (GAGs) have a range of biological roles and are of particular interest for their pharmaceutical efficacy and their potential as biomarkers or drug targets. Heparin, used globally as an anticoagulant and an antithrombotic, is predominantly derived from porcine sources but bovine and ovine sources are ... | 2026-01-01 |
41211846 | Regulating the Li/Ni Mixing Ratio to Enhance Transition Metal-Lattice Oxygen Interaction for Achieving Long Life Lithium-Rich Layered Oxides. | Lithium-rich layered oxides (LLOs) emerge as promising cathode materials for next-generation high-performance Li-ion batteries (LIBs) due to their superior specific capacity characteristics. The similar ionic radii of Li<sup>+</sup> (0.72 Å) and Ni<sup>2+</sup> (0.69 Å) inevitably cause Li/Ni mixing. However, the relat... | 2025-11-10 |
41179853 | A One-Year Retrospective Observational Study of an Occupational Medicine Outpatient Clinic in a City Hospital. | <i>Background:</i> Occupational diseases (ODs) remain a major public health concern. Despite advances in occupational health (OH), many workers remain at risk due to insufficient preventive measures and limited access to specialized care. <i>Objective:</i> This study aimed to evaluate the sociodemographic and occupatio... | 2025-01-01 |
41191684 | A 5-Year Survey on Multiple Targeted Benzimidazole Hybrids. | Among heterocyclic compounds, the various biological activities and the easily modifiable chemical structure of benzimidazole compounds make them important in drug development. Currently, the demand for treatments targeting multiple biological pathways is increasing. In the treatment of multifaceted diseases, drugs exh... | 2025-11-05 |
41163192 | Non-linear association between Life's Essential 8 and diabetic retinopathy: mediating role of depression in US adults with diabetes. | Life's Essential 8 (LE8) is a comprehensive cardiovascular health (CVH) metric that is associated with chronic diseases. This study aimed to investigate the association between LE8 and diabetic retinopathy (DR) and the mediating role of depression in this association. We analyzed cross-sectional data from 3,815 adults ... | 2025-10-29 |
41173028 | Mid-term clinical outcomes of the unlinked type K-NOW total elbow arthroplasty. | This study aimed to evaluate the mid-term clinical outcomes, complications, and survival rates of the unlinked K-NOW (Teijin Nakashima Medical, Japan) total elbow arthroplasty (TEA), focusing on the use of cementless fixation. This retrospective study included 41 elbows in 37 patients who underwent primary TEA using un... | 2025-11-01 |
41190752 | Construction and validation of a risk prediction model for secondary acute kidney injury in patients with acute upper gastrointestinal bleeding. | Objective Acute upper gastrointestinal bleeding (AUGIB) is one of the most common critical conditions in clinical practice and is characterized by rapid progression and a high incidence of secondary acute kidney injury (AKI). This study aimed to analyze the clinical characteristics of patients with AUGIB, identify rela... | 2025-11-05 |
41193287 | Uniform and reliable assessment of bone union on radiographs in osteotomies around the knee: a novel classification system. | To evaluate the inter- and intra-rater reliability of the Unified Bone Union (UBU) classification for assessing time-dependent bone healing on radiographs in osteotomies around the knee, including negative union signs. Secondary aims included assessing union progression over time, applicability across osteotomy types, ... | 2025-11-04 |
41185286 | Neem oil emulsions stabilized by natural and synthetic emulsifiers: a study on physical stability and antifungal activity. | Neem oil (NO) is a plant-derived bioactive compound with known antimicrobial properties. Incorporating NO into oil-in-water (O/W) emulsions can improve its stability, bioavailability, and allow controlled release. This study developed and characterized O/W emulsions using NO as the dispersed phase and active agent. Emu... | 2025-12-01 |
41164666 | An <i>In-vitro</i> Assessment of Potassium Iodide and Glutathione on Color Change Caused by Silver Diamine Fluoride Treatment. | To assess and contrast the impact of glutathione (GSH) and potassium iodide (KI) on tooth discoloration brought on by silver diamine fluoride (SDF) treatment on primary incisors. Standardized 2 mm × 2 mm (depth × width) of cavities were made on labial surface of each specimen, and artificial caries was created on 40 ex... | 2025-09-01 |
41211647 | The association of periodontal inflammation and inflammatory markers with cognitive dysfunction: A case-control study. | This study investigated the association of inflammatory markers in saliva, plasma, and cerebrospinal fluid (CSF) with cognitive decline and periodontitis. Patients with Alzheimer disease (AD, n = 52), mild cognitive impairment (MCI, n = 51), subjective cognitive decline (SCD, n = 51), and controls (n = 76) between 50 a... | 2025-11-10 |
41191323 | Cerebral microbleeds aggravate severity of motor function, cognitive and emotional status in Parkinson's disease. | Cerebral microbleeds (CMBs) are highly prevalent in patients with Parkinson's disease (PD), but their impact on clinical symptom severity and genetic association remains unclear. This study investigates the relationship between CMBs and PD severity. We recruited patients with PD from the outpatient clinic and inpatient... | 2025-11-05 |
41180305 | Single-Nuclei RNA Sequencing Shows the Engagement of PPAR-Delta Target Genes Primarily in Hepatocytes and Cholangiocytes by the Selective PPAR-Delta Agonist Seladelpar. | The selective peroxisome proliferator-activated receptor delta (PPARD) agonist seladelpar reduces liver injury and modulates bile acid metabolism in preclinical models. Seladelpar was recently approved for the secondary treatment of primary biliary cholangitis (PBC). Despite its beneficial effects for liver diseases, t... | 2025-01-01 |
41175199 | Heterogeneity in clinically diagnosed type 1 diabetes: characterising a unique cohort with maintained C-peptide secretion in Ghana. | In sub-Saharan Africa, type 1 diabetes is typically diagnosed clinically, which can be challenging due to atypical diabetes presentations such as ketosis-prone type 2 diabetes or type 2 diabetes in the absence of overweight and obesity. C-peptide, a marker of residual insulin secretion capacity, is crucial for understa... | 2025-11-01 |
41188435 | Acute effect of light and time of day on thermal physiology, perception, and behavior. | Implementing novel, human-centric building control strategies that account for the interaction of multidomain factors, light, temperature, and time of day, can enhance occupant comfort and promote energy savings. However, their successful implementations require a robust framework that clearly explains the physiologica... | 2025-11-04 |
41167217 | Physical examinations and whole-body imaging versus physical examinations alone during follow-up after radical surgery of stage IIB-C and III cutaneous malignant melanoma (TRIM): an interim analysis of a multicentre, randomised, phase 3 trial in Sweden. | In several countries, whole-body imaging has been introduced in the routine follow-up of individuals with high-risk cutaneous malignant melanoma after surgery. However, there is scarce evidence that earlier detection of recurrent disease by regular scanning improves survival. In this interim analysis, we investigated w... | 2025-11-01 |
41169950 | Adverse events beyond the RUBY trial: reporting immunotherapy-associated myocarditis, myositis, and myasthenia gravis in a real-world endometrial cancer case. | To report a rare case of immune checkpoint inhibitor (ICI)-associated myocarditis, myositis, and myasthenia gravis (MMM syndrome) in a patient with advanced endometrial cancer treated with dostarlimab, highlighting the diagnostic and therapeutic challenges, in addition to the importance of biomarker-informed treatment ... | 2025-10-01 |
41180056 | Lived experiences of individuals with cyberviolence: Understanding the nature of the dark side of social media use. | The advancement in technology has given more people accessibility to internet and social media. Technological advances have led to the exponential rise of cybercrime, with an average of 7000 cases being reported in India every day in 2024. Given the potential harmful consequences, a thorough understanding of this pheno... | 2025-01-01 |
41196917 | Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β- and α+/γ- transmembrane subunit interfaces of synaptic GABAA receptors. | General anesthesia induced by etomidate, barbiturates and propofol is associated with positive modulation of synaptic αβγ GABAA receptors, inhibitory hetero-pentameric ligand-gated ion channels formed from homologous subunits arranged β-α-β-α-γ around a central gated chloride channel. Approaches based on mutations, ami... | 2025-01-01 |
41166054 | Measurement of gamma-ray dose rate distribution at the Kindai university reactor using the thermoluminescent properties of BeO ceramic plates. | The gamma-ray dose rate distribution at the Kindai University Reactor (UTR-KINKI) was measured using the thermoluminescent (TL) properties of beryllium oxide (BeO) ceramic plates. The reactor, operating at an extremely low thermal power of 1 W, is widely used for nuclear research, including radiation biology and detect... | 2025-10-30 |
41180005 | Thalidomide as an Adjunctive Therapy for HIV-Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome: A Case Series. | A small proportion of people living with human immunodeficiency virus (HIV) who have tuberculosis-related immune reconstitution inflammatory syndrome (tuberculosis-IRIS) have prolonged and complicated courses and experience poor response to corticosteroid therapy, relapse after withdrawing, or intolerability demonstrat... | 2025-11-01 |
41202991 | A virtual mind-body exercise program during breast radiation: Results from a randomized controlled basket trial. | National guidelines recommend fitness and mind-body exercise to reduce cancer-related fatigue, but substantial barriers to implementation exist. Virtual programs offer a scalable approach to address this gap. This study aims to evaluate efficacy of a virtual fitness and mind-body exercise program (Integrative Medicine ... | 2025-11-05 |
41171604 | Three-dimensional visualisation of human ovarian follicles using a whole-mount immunolabelling and optical tissue clearing method. | To more accurately classify human ovarian follicles by developing a novel methodology with three-dimensional visualisation using whole-mount immunolabelling and optical tissue clearing techniques. A whole-mount immunolabelling protocol combined with optical tissue clearing was applied to human ovarian tissue for three-... | 2025-10-01 |
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