id stringlengths 1 3 | document_id stringlengths 11 13 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
100 | PMID-9648911 | [
{
"id": "PMID-9648911__text",
"type": "abstract",
"text": [
"Induction of Ets-1 in endothelial cells during reendothelialization after denuding injury.\n\nEts-1, a transcription factor, is induced in endothelial cells (ECs) during angiogenesis. Here, we investigated the expression of Ets-1 during ... | [
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"Ets-1"
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13,
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{
"id": "PMID-9648911_T3",
"type": "Cell",
"text": [
"endothelial cells"
],
"offsets": [
[
... | [
{
"id": "PMID-9648911_E1",
"type": "Positive_regulation",
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"text": [
"Induction"
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0,
9
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},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-9648911_T2"
}
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},
... | [
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{
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},
{
"id": "PMID-9648911_3",
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"PMID-9648911_T40",
"PMID-... | [
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}
] |
101 | PMID-9891506 | [
{
"id": "PMID-9891506__text",
"type": "abstract",
"text": [
"Effect of U-995, a potent shark cartilage-derived angiogenesis inhibitor, on anti-angiogenesis and anti-tumor activities.\n\nBACKGROUND: A potent angiogenesis inhibitor, U-995, has been purified from the cartilage of the blue shark (Prio... | [
{
"id": "PMID-9891506_T2",
"type": "Gene_or_gene_product",
"text": [
"U-995"
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10,
15
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"normalized": []
},
{
"id": "PMID-9891506_T3",
"type": "Tissue",
"text": [
"cartilage"
],
"offsets": [
[
... | [
{
"id": "PMID-9891506_E7",
"type": "Negative_regulation",
"trigger": {
"text": [
"activities"
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110,
120
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},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-9891506_T2"
},
{... | [
{
"id": "PMID-9891506_1",
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"PMID-9891506_T19",
"PMID-9891506_T21"
]
},
{
"id": "PMID-9891506_2",
"entity_ids": [
"PMID-9891506_T24",
"PMID-9891506_T25"
]
}
] | [] |
102 | PMID-10586954 | [
{
"id": "PMID-10586954__text",
"type": "abstract",
"text": [
"Insulin-induced vascular endothelial growth factor expression in retina.\n\nPURPOSE: Clinical studies have demonstrated that intensive insulin therapy causes a transient worsening of retinopathy. The mechanisms underlying the initial in... | [
{
"id": "PMID-10586954_T2",
"type": "Gene_or_gene_product",
"text": [
"Insulin"
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0,
7
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{
"id": "PMID-10586954_T3",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth facto... | [
{
"id": "PMID-10586954_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expression"
],
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51,
61
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10586954_T3"
}
]
},
... | [
{
"id": "PMID-10586954_1",
"entity_ids": [
"PMID-10586954_T7",
"PMID-10586954_T8"
]
}
] | [
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"type": "frag",
"arg1_id": "PMID-10586954_T37",
"arg2_id": "PMID-10586954_T39",
"normalized": []
}
] |
103 | PMID-19636328 | [
{
"id": "PMID-19636328__text",
"type": "abstract",
"text": [
"Targeting angiogenesis: progress with anti-VEGF treatment with large molecules.\n\nAngiogenesis--one of the hallmarks of cancer--has emerged as a valid therapeutic target in oncology. The VEGF system represents a key mediator of tumor-i... | [
{
"id": "PMID-19636328_T2",
"type": "Gene_or_gene_product",
"text": [
"VEGF"
],
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43,
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"normalized": []
},
{
"id": "PMID-19636328_T5",
"type": "Gene_or_gene_product",
"text": [
"VEGF"
],
"offsets": [
... | [
{
"id": "PMID-19636328_E1",
"type": "Planned_process",
"trigger": {
"text": [
"treating"
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},
"arguments": [
{
"role": "Instrument",
"ref_id": "PMID-19636328_T17"
},
... | [] | [] |
104 | PMID-18245558 | [
{
"id": "PMID-18245558__text",
"type": "abstract",
"text": [
"Suppression of lung tumor growth and metastasis in mice by adeno-associated virus-mediated expression of vasostatin.\n\nPURPOSE: Angiogenesis inhibitors have strong therapeutic potential as antitumor agents in suppressing tumor growth a... | [
{
"id": "PMID-18245558_T4",
"type": "Pathological_formation",
"text": [
"lung tumor"
],
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15,
25
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"normalized": []
},
{
"id": "PMID-18245558_T6",
"type": "Gene_or_gene_product",
"text": [
"vasostatin"
],
"of... | [
{
"id": "PMID-18245558_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Suppression"
],
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[
0,
11
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]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-18245558_E5"
},
{... | [
{
"id": "PMID-18245558_1",
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"PMID-18245558_T1002",
"PMID-18245558_T17"
]
},
{
"id": "PMID-18245558_2",
"entity_ids": [
"PMID-18245558_T8",
"PMID-18245558_T20"
]
}
] | [
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},
{
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"type": "frag",
"arg1_id": "PMID-18245558_T67",
"arg2_id": "PMID-18245558_T22",
"normalized": []
}
] |
105 | PMID-19574426 | [
{
"id": "PMID-19574426__text",
"type": "abstract",
"text": [
"Angiogenesis in platelet endothelial cell adhesion molecule-1-null mice.\n\nPlatelet endothelial cell adhesion molecule (PECAM)-1 has been previously implicated in endothelial cell migration; additionally, anti-PECAM-1 antibodies have b... | [
{
"id": "PMID-19574426_T2",
"type": "Gene_or_gene_product",
"text": [
"platelet endothelial cell adhesion molecule-1"
],
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[
16,
61
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"normalized": []
},
{
"id": "PMID-19574426_T3",
"type": "Gene_or_gene_product",
"text": [
... | [
{
"id": "PMID-19574426_E5",
"type": "Localization",
"trigger": {
"text": [
"migration"
],
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[
179,
188
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19574426_T6"
}
]
},
{... | [] | [] |
106 | PMID-18505892 | [
{
"id": "PMID-18505892__text",
"type": "abstract",
"text": [
"Adenomatoid tumour of the liver.\n\nAn unusual primary adenomatoid tumour arising in the normal liver is described. Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery. Grossly, the tumour showed a... | [
{
"id": "PMID-18505892_T1",
"type": "Pathological_formation",
"text": [
"Adenomatoid tumour"
],
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[
0,
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"normalized": []
},
{
"id": "PMID-18505892_T2",
"type": "Organ",
"text": [
"liver"
],
"offsets": [
... | [
{
"id": "PMID-18505892_E13",
"type": "Growth",
"trigger": {
"text": [
"proliferated"
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[
543,
555
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18505892_T15"
}
]
},
{
... | [] | [] |
107 | PMID-7586219 | [
{
"id": "PMID-7586219__text",
"type": "abstract",
"text": [
"VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo.\n\nTo evaluate the concept that localized delivery of angiogenic factors via virus-mediated gene transfer may be useful in the treat... | [
{
"id": "PMID-7586219_T2",
"type": "Gene_or_gene_product",
"text": [
"VEGF165"
],
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[
0,
7
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],
"normalized": []
},
{
"id": "PMID-7586219_T6",
"type": "Gene_or_gene_product",
"text": [
"VEGF165"
],
"offsets": [
... | [
{
"id": "PMID-7586219_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"expressed"
],
"offsets": [
[
8,
17
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-7586219_T2"
}
]
},
{
... | [
{
"id": "PMID-7586219_1",
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"PMID-7586219_T7",
"PMID-7586219_T8"
]
},
{
"id": "PMID-7586219_2",
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"PMID-7586219_T13",
"PMID-7586219_T14"
]
},
{
"id": "PMID-7586219_3",
"entity_ids": [
"PMID-7586219_T16",
"PMID-75... | [] |
108 | PMID-11387198 | [
{
"id": "PMID-11387198__text",
"type": "abstract",
"text": [
"Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism.\n\nThe angiogenic switch during tumorigenesis is thought to be induced by a change in the balance of pro- angiogenic and an... | [
{
"id": "PMID-11387198_T1",
"type": "Gene_or_gene_product",
"text": [
"Thrombospondin-2"
],
"offsets": [
[
0,
16
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],
"normalized": []
},
{
"id": "PMID-11387198_T2",
"type": "Pathological_formation",
"text": [
"tumor"
],
"of... | [
{
"id": "PMID-11387198_E12",
"type": "Positive_regulation",
"trigger": {
"text": [
"upregulated"
],
"offsets": [
[
524,
535
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-11387198_E13"
}
... | [
{
"id": "PMID-11387198_1",
"entity_ids": [
"PMID-11387198_T8",
"PMID-11387198_T9"
]
}
] | [] |
109 | PMID-18194650 | [
{
"id": "PMID-18194650__text",
"type": "abstract",
"text": [
"Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.\n\nVascular endothelial growth factor (VEGF) and Angiopoietin 1 (Ang1) are both potent proangiogenic factors, but, whereas VEGF causes vascu... | [
{
"id": "PMID-18194650_T1",
"type": "Gene_or_gene_product",
"text": [
"Angiopoietin-1"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "PMID-18194650_T2",
"type": "Gene_or_gene_product",
"text": [
"VEGF"
],
"offsets... | [
{
"id": "PMID-18194650_E17",
"type": "Positive_regulation",
"trigger": {
"text": [
"induce"
],
"offsets": [
[
473,
479
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18194650_E19"
},
{... | [
{
"id": "PMID-18194650_1",
"entity_ids": [
"PMID-18194650_T5",
"PMID-18194650_T6"
]
},
{
"id": "PMID-18194650_2",
"entity_ids": [
"PMID-18194650_T7",
"PMID-18194650_T8"
]
}
] | [] |
110 | PMID-17608264 | [
{
"id": "PMID-17608264__text",
"type": "abstract",
"text": [
"An assay to measure angiogenesis in human fat tissue.\n\nBACKGROUND: Inhibition of angiogenesis reverses rodent obesity. A validated assay in human fat tissue is needed to study the role of angiogenesis in human obesity. METHODS: Human ... | [
{
"id": "PMID-17608264_T3",
"type": "Tissue",
"text": [
"fat tissue"
],
"offsets": [
[
42,
52
]
],
"normalized": []
},
{
"id": "PMID-17608264_T5",
"type": "Tissue",
"text": [
"fat tissue"
],
"offsets": [
[
146,... | [
{
"id": "PMID-17608264_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Inhibition"
],
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[
67,
77
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17608264_E22"
}
]
... | [
{
"id": "PMID-17608264_1",
"entity_ids": [
"PMID-17608264_T37",
"PMID-17608264_T38"
]
}
] | [] |
111 | PMID-10417401 | [
{
"id": "PMID-10417401__text",
"type": "abstract",
"text": [
"Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor.\n\nA marked coronary angiogenesis is known to occur with chronic bradycardia. We tested the hypothesis that vascular endothelial growth factor... | [
{
"id": "PMID-10417401_T3",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor"
],
"offsets": [
[
58,
92
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],
"normalized": []
},
{
"id": "PMID-10417401_T6",
"type": "Gene_or_gene_product",
"text": [
"vasc... | [
{
"id": "PMID-10417401_E5",
"type": "Positive_regulation",
"trigger": {
"text": [
"upregulated"
],
"offsets": [
[
313,
324
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-10417401_T6"
}
]... | [
{
"id": "PMID-10417401_1",
"entity_ids": [
"PMID-10417401_T6",
"PMID-10417401_T7"
]
}
] | [] |
112 | PMID-18188789 | [
{
"id": "PMID-18188789__text",
"type": "abstract",
"text": [
"[Photodynamic therapy in severe chronic central serous chorioretinopaty]\n\nOBJECTIVE: To determine the efficacy of Photodynamic Therapy (PDT) in chronic Central Serous Chorioretinopathy (CSC). METHODS: Patients diagnosed with chronic C... | [
{
"id": "PMID-18188789_T1",
"type": "Drug_or_compound",
"text": [
"fluorescein"
],
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[
489,
500
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],
"normalized": []
},
{
"id": "PMID-18188789_T2",
"type": "Drug_or_compound",
"text": [
"indocyanine"
],
"offsets"... | [
{
"id": "PMID-18188789_E7",
"type": "Positive_regulation",
"trigger": {
"text": [
"increase"
],
"offsets": [
[
1105,
1113
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18188789_T8"
}
]
... | [
{
"id": "PMID-18188789_1",
"entity_ids": [
"PMID-18188789_T8",
"PMID-18188789_T9"
]
}
] | [] |
113 | PMID-18852899 | [
{
"id": "PMID-18852899__text",
"type": "abstract",
"text": [
"M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo.\n\nBACKGROUND: M-CSF recruits mononuclear phagocytes which regulate processes such as angiogenesis and metastases in tumors. ... | [
{
"id": "PMID-18852899_T1",
"type": "Gene_or_gene_product",
"text": [
"M-CSF"
],
"offsets": [
[
0,
5
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],
"normalized": []
},
{
"id": "PMID-18852899_T3",
"type": "Gene_or_gene_product",
"text": [
"MAPK"
],
"offsets": [
... | [
{
"id": "PMID-18852899_E6",
"type": "Gene_expression",
"trigger": {
"text": [
"production"
],
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[
66,
76
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-18852899_T7"
}
]
},
... | [] | [] |
114 | PMID-15029197 | [
{
"id": "PMID-15029197__text",
"type": "abstract",
"text": [
"The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.\n\nGliomas are the most common primary tumours of the central nervous system, with nearly 15,000 diagnosed annually in the United States and a ... | [
{
"id": "PMID-15029197_T1",
"type": "Pathological_formation",
"text": [
"tumour"
],
"offsets": [
[
14,
20
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],
"normalized": []
},
{
"id": "PMID-15029197_T2",
"type": "Gene_or_gene_product",
"text": [
"ING4"
],
"offsets": [
... | [
{
"id": "PMID-15029197_E3",
"type": "Regulation",
"trigger": {
"text": [
"regulates"
],
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[
45,
54
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]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-15029197_T2"
},
{
"... | [
{
"id": "PMID-15029197_1",
"entity_ids": [
"PMID-15029197_T40",
"PMID-15029197_T41"
]
}
] | [] |
115 | PMID-15723619 | [
{
"id": "PMID-15723619__text",
"type": "abstract",
"text": [
"Novel biological agents for the treatment of hormone-refractory prostate cancer (HRPC).\n\nHormone-refractory prostate cancer (HRPC) is an inevitable evolution of prostate carcinogenesis, through which the normal dependence on hormones ... | [
{
"id": "PMID-15723619_T1",
"type": "Pathological_formation",
"text": [
"hormone-refractory prostate cancer"
],
"offsets": [
[
45,
79
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],
"normalized": []
},
{
"id": "PMID-15723619_T3",
"type": "Pathological_formation",
"text": [
"... | [
{
"id": "PMID-15723619_E1",
"type": "Planned_process",
"trigger": {
"text": [
"treatment"
],
"offsets": [
[
32,
41
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15723619_T1"
}
]
},
... | [
{
"id": "PMID-15723619_1",
"entity_ids": [
"PMID-15723619_T1",
"PMID-15723619_T3"
]
},
{
"id": "PMID-15723619_2",
"entity_ids": [
"PMID-15723619_T4",
"PMID-15723619_T6"
]
}
] | [] |
116 | PMID-19760065 | [
{
"id": "PMID-19760065__text",
"type": "abstract",
"text": [
"Targeting TNF for Treatment of Cancer and Autoimmunity.\n\nTumor necrosis factor-alpha (TNF-alpha) was first isolated two decades ago as a macrophageproduced protein that can effectively kill tumor cells. TNF-alpha is also an essential ... | [
{
"id": "PMID-19760065_T2",
"type": "Gene_or_gene_product",
"text": [
"TNF"
],
"offsets": [
[
10,
13
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],
"normalized": []
},
{
"id": "PMID-19760065_T3",
"type": "Gene_or_gene_product",
"text": [
"Tumor necrosis factor-alpha"
],... | [
{
"id": "PMID-19760065_E5",
"type": "Death",
"trigger": {
"text": [
"kill"
],
"offsets": [
[
185,
189
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]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19760065_T6"
}
]
},
{
"id": "... | [
{
"id": "PMID-19760065_1",
"entity_ids": [
"PMID-19760065_T3",
"PMID-19760065_T4"
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},
{
"id": "PMID-19760065_2",
"entity_ids": [
"PMID-19760065_T22",
"PMID-19760065_T23"
]
},
{
"id": "PMID-19760065_3",
"entity_ids": [
"PMID-19760065_T25",
... | [] |
117 | PMID-17311993 | [
{
"id": "PMID-17311993__text",
"type": "abstract",
"text": [
"Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.\n\nVascular development is dependent on various growth factors and certain modifiers critical for providing arterial o... | [
{
"id": "PMID-17311993_T3",
"type": "Gene_or_gene_product",
"text": [
"Dll4"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "PMID-17311993_T7",
"type": "Multi-tissue_structure",
"text": [
"vessels"
],
"offsets": [... | [
{
"id": "PMID-17311993_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"Inhibition"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17311993_E34"
}
]
... | [] | [] |
118 | PMID-15034302 | [
{
"id": "PMID-15034302__text",
"type": "abstract",
"text": [
"TGFbeta1, back to the future: revisiting its role as a transforming growth factor.\n\nTGFbeta1 was initially identified in culture media from transformed cells as part of a factor that could produce a transformed phenotype in a nontrans... | [
{
"id": "PMID-15034302_T1",
"type": "Gene_or_gene_product",
"text": [
"TGFbeta1"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "PMID-15034302_T2",
"type": "Gene_or_gene_product",
"text": [
"TGFbeta1"
],
"offsets": ... | [
{
"id": "PMID-15034302_E17",
"type": "Gene_expression",
"trigger": {
"text": [
"overexpress"
],
"offsets": [
[
653,
664
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15034302_T19"
}
]
... | [] | [] |
119 | PMID-16485028 | [
{
"id": "PMID-16485028__text",
"type": "abstract",
"text": [
"NF-kappaB and IKK as therapeutic targets in cancer.\n\nThe transcription factor NF-kappaB and associated regulatory factors (including IkappaB kinase subunits and the IkappaB family member Bcl-3) are strongly implicated in a variety of ... | [
{
"id": "PMID-16485028_T1",
"type": "Gene_or_gene_product",
"text": [
"NF-kappaB"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "PMID-16485028_T2",
"type": "Gene_or_gene_product",
"text": [
"IKK"
],
"offsets": [
... | [
{
"id": "PMID-16485028_E12",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibition"
],
"offsets": [
[
529,
539
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16485028_T13"
}
... | [] | [] |
120 | PMID-19542562 | [
{
"id": "PMID-19542562__text",
"type": "abstract",
"text": [
"Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase.\n\nSmooth muscle-rich tissues respond to mechanical overload by an adaptive... | [
{
"id": "PMID-19542562_T3",
"type": "Gene_or_gene_product",
"text": [
"CCN1"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "PMID-19542562_T4",
"type": "Gene_or_gene_product",
"text": [
"CYR61"
],
"offsets": [
... | [
{
"id": "PMID-19542562_E1",
"type": "Regulation",
"trigger": {
"text": [
"regulation"
],
"offsets": [
[
11,
21
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19542562_T3"
}
]
},
{
... | [
{
"id": "PMID-19542562_1",
"entity_ids": [
"PMID-19542562_T22",
"PMID-19542562_T23"
]
},
{
"id": "PMID-19542562_2",
"entity_ids": [
"PMID-19542562_T27",
"PMID-19542562_T26"
]
},
{
"id": "PMID-19542562_3",
"entity_ids": [
"PMID-19542562_T3",
... | [
{
"id": "PMID-19542562_R1",
"type": "frag",
"arg1_id": "PMID-19542562_T30",
"arg2_id": "PMID-19542562_T45",
"normalized": []
}
] |
121 | PMID-9728053 | [
{
"id": "PMID-9728053__text",
"type": "abstract",
"text": [
"Store-operated calcium entry promotes shape change in pulmonary endothelial cells expressing Trp1.\n\nActivation of Ca2+ entry is known to produce endothelial cell shape change, leading to increased permeability, leukocyte migration, and... | [
{
"id": "PMID-9728053_T1",
"type": "Drug_or_compound",
"text": [
"calcium"
],
"offsets": [
[
15,
22
]
],
"normalized": []
},
{
"id": "PMID-9728053_T2",
"type": "Cell",
"text": [
"pulmonary endothelial cells"
],
"offsets": [
... | [
{
"id": "PMID-9728053_E17",
"type": "Regulation",
"trigger": {
"text": [
"reconfiguration"
],
"offsets": [
[
798,
813
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-9728053_T18"
}
]
},... | [
{
"id": "PMID-9728053_1",
"entity_ids": [
"PMID-9728053_T18",
"PMID-9728053_T19"
]
},
{
"id": "PMID-9728053_2",
"entity_ids": [
"PMID-9728053_T21",
"PMID-9728053_T22"
]
}
] | [] |
122 | PMID-15975645 | [
{
"id": "PMID-15975645__text",
"type": "abstract",
"text": [
"Thalidomide and angiostatin inhibit tumor growth in a murine xenograft model of human cervical cancer.\n\nOBJECTIVE: To determine the impact of thalidomide and angiostatin on tumor growth, angiogenesis, and apoptosis in a xenograft mode... | [
{
"id": "PMID-15975645_T1",
"type": "Drug_or_compound",
"text": [
"Thalidomide"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "PMID-15975645_T2",
"type": "Gene_or_gene_product",
"text": [
"angiostatin"
],
"offsets... | [
{
"id": "PMID-15975645_E3",
"type": "Negative_regulation",
"trigger": {
"text": [
"inhibit"
],
"offsets": [
[
28,
35
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15975645_T5"
},
{
... | [] | [] |
123 | PMID-17289834 | [
{
"id": "PMID-17289834__text",
"type": "abstract",
"text": [
"Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.\n\nHyperforin (Hyp), a polyphenol-derivative of St. John's wort (Hyper... | [
{
"id": "PMID-17289834_T2",
"type": "Drug_or_compound",
"text": [
"Hyperforin"
],
"offsets": [
[
0,
10
]
],
"normalized": []
},
{
"id": "PMID-17289834_T4",
"type": "Cell",
"text": [
"neutrophil"
],
"offsets": [
[
... | [
{
"id": "PMID-17289834_E1",
"type": "Negative_regulation",
"trigger": {
"text": [
"blocks"
],
"offsets": [
[
11,
17
]
]
},
"arguments": [
{
"role": "Cause",
"ref_id": "PMID-17289834_T2"
},
{
... | [
{
"id": "PMID-17289834_1",
"entity_ids": [
"PMID-17289834_T17",
"PMID-17289834_T18"
]
},
{
"id": "PMID-17289834_2",
"entity_ids": [
"PMID-17289834_T10",
"PMID-17289834_T11"
]
},
{
"id": "PMID-17289834_3",
"entity_ids": [
"PMID-17289834_T58",
... | [] |
124 | PMID-16045802 | [
{
"id": "PMID-16045802__text",
"type": "abstract",
"text": [
"Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis.\n\nBACKGROUND: The effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second,... | [
{
"id": "PMID-16045802_T2",
"type": "Pathological_formation",
"text": [
"breast cancer xenograft"
],
"offsets": [
[
72,
95
]
],
"normalized": []
},
{
"id": "PMID-16045802_T5",
"type": "Pathological_formation",
"text": [
"MDA MB231 b... | [
{
"id": "PMID-16045802_E1",
"type": "Growth",
"trigger": {
"text": [
"growth"
],
"offsets": [
[
96,
102
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-16045802_T2"
}
]
},
{
"id":... | [
{
"id": "PMID-16045802_1",
"entity_ids": [
"PMID-16045802_T14",
"PMID-16045802_T15"
]
}
] | [] |
125 | PMID-7897308 | [
{
"id": "PMID-7897308__text",
"type": "abstract",
"text": [
"Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells.\n\nMetastatic disease is one of the major causes of death from cancer in human beings. Several enzyme systems have been implicated i... | [
{
"id": "PMID-7897308_T1",
"type": "Drug_or_compound",
"text": [
"doxycycline"
],
"offsets": [
[
11,
22
]
],
"normalized": []
},
{
"id": "PMID-7897308_T4",
"type": "Cell",
"text": [
"breast carcinoma cells"
],
"offsets": [
... | [
{
"id": "PMID-7897308_E2",
"type": "Cell_proliferation",
"trigger": {
"text": [
"growth"
],
"offsets": [
[
35,
41
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-7897308_T4"
}
]
},
{
... | [
{
"id": "PMID-7897308_1",
"entity_ids": [
"PMID-7897308_T6",
"PMID-7897308_T7"
]
}
] | [] |
126 | PMID-19742300 | [
{
"id": "PMID-19742300__text",
"type": "abstract",
"text": [
"Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.\n\nBACKGROUND: Inflammation followed by fibrosis is a component of islet dysfunction in both rodent and huma... | [
{
"id": "PMID-19742300_T2",
"type": "Tissue",
"text": [
"Islet endothelial"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "PMID-19742300_T3",
"type": "Drug_or_compound",
"text": [
"IL-1Ra"
],
"offsets": [
[
... | [
{
"id": "PMID-19742300_E1",
"type": "Positive_regulation",
"trigger": {
"text": [
"activation"
],
"offsets": [
[
18,
28
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-19742300_T2"
}
]
... | [
{
"id": "PMID-19742300_1",
"entity_ids": [
"PMID-19742300_T15",
"PMID-19742300_T18"
]
},
{
"id": "PMID-19742300_2",
"entity_ids": [
"PMID-19742300_T20",
"PMID-19742300_T21"
]
}
] | [
{
"id": "PMID-19742300_R1",
"type": "frag",
"arg1_id": "PMID-19742300_T16",
"arg2_id": "PMID-19742300_T46",
"normalized": []
},
{
"id": "PMID-19742300_R2",
"type": "frag",
"arg1_id": "PMID-19742300_T71",
"arg2_id": "PMID-19742300_T1003",
"normalized": []
}
] |
127 | PMID-15715968 | [
{
"id": "PMID-15715968__text",
"type": "abstract",
"text": [
"Expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 for inhibitor screening.\n\nVascular endothelial growth factor (VEGF), an endothelial cell-specific mitogen, can act in tumor-ind... | [
{
"id": "PMID-15715968_T2",
"type": "Gene_or_gene_product",
"text": [
"vascular endothelial growth factor receptor 2"
],
"offsets": [
[
61,
106
]
],
"normalized": []
},
{
"id": "PMID-15715968_T3",
"type": "Gene_or_gene_product",
"text": [... | [
{
"id": "PMID-15715968_E1",
"type": "Gene_expression",
"trigger": {
"text": [
"Expression"
],
"offsets": [
[
0,
10
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15715968_T2"
}
]
},
... | [
{
"id": "PMID-15715968_1",
"entity_ids": [
"PMID-15715968_T3",
"PMID-15715968_T4"
]
}
] | [] |
128 | PMID-12167423 | [
{
"id": "PMID-12167423__text",
"type": "abstract",
"text": [
"Molecular characterization of angiogenic properties of human oral squamous cell carcinoma cells.\n\nLittle is known about the specificity of angiogenic properties of oral cancer cells and the possible mechanisms. Stimulatory effects on ... | [
{
"id": "PMID-12167423_T2",
"type": "Cell",
"text": [
"oral squamous cell carcinoma cells"
],
"offsets": [
[
61,
95
]
],
"normalized": []
},
{
"id": "PMID-12167423_T4",
"type": "Cell",
"text": [
"oral cancer cells"
],
"offse... | [
{
"id": "PMID-12167423_E8",
"type": "Cell_proliferation",
"trigger": {
"text": [
"proliferation"
],
"offsets": [
[
234,
247
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-12167423_T11"
}
... | [
{
"id": "PMID-12167423_1",
"entity_ids": [
"PMID-12167423_T34",
"PMID-12167423_T35"
]
},
{
"id": "PMID-12167423_2",
"entity_ids": [
"PMID-12167423_T19",
"PMID-12167423_T20"
]
},
{
"id": "PMID-12167423_3",
"entity_ids": [
"PMID-12167423_T11",
... | [] |
129 | PMID-17306711 | [
{
"id": "PMID-17306711__text",
"type": "abstract",
"text": [
"Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease.\n\nOBJECTIVES: This study sought to assess the cellular and histologic... | [
{
"id": "PMID-17306711_T2",
"type": "Cell",
"text": [
"pulmonary endothelial cells"
],
"offsets": [
[
22,
49
]
],
"normalized": []
},
{
"id": "PMID-17306711_T4",
"type": "Organ",
"text": [
"heart"
],
"offsets": [
[
... | [
{
"id": "PMID-17306711_E1",
"type": "Death",
"trigger": {
"text": [
"apoptosis"
],
"offsets": [
[
9,
18
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-17306711_T2"
}
]
},
{
"id":... | [] | [
{
"id": "PMID-17306711_R1",
"type": "frag",
"arg1_id": "PMID-17306711_T9",
"arg2_id": "PMID-17306711_T11",
"normalized": []
}
] |
130 | PMID-15510518 | [
{
"id": "PMID-15510518__text",
"type": "abstract",
"text": [
"[Glaucoma and ocular ischemic syndrome--case report]\n\nPURPOSE: Ocular ischemic syndrome (OIS) is often poorly diagnosed and treated as primary open angle glaucoma or later on, as neovascular glaucoma. We present a 54 year old male, tr... | [
{
"id": "PMID-15510518_T2",
"type": "Organ",
"text": [
"eye"
],
"offsets": [
[
364,
367
]
],
"normalized": []
},
{
"id": "PMID-15510518_T3",
"type": "Multi-tissue_structure",
"text": [
"iris"
],
"offsets": [
[
... | [
{
"id": "PMID-15510518_E2",
"type": "Planned_process",
"trigger": {
"text": [
"treated"
],
"offsets": [
[
232,
239
]
]
},
"arguments": [
{
"role": "Theme",
"ref_id": "PMID-15510518_T21"
}
]
},
... | [] | [] |
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