id stringlengths 7 9 | document_id stringlengths 7 8 | passages list | entities list | events list | coreferences list | relations list |
|---|---|---|---|---|---|---|
IEPA.d132 | 10563891 | [
{
"id": "IEPA.d132.s319",
"type": "",
"text": [
"The effects of the fluorinated analogues were evaluated on inhibition of cress seed germination and inhibition of gibberellin-inducible alpha-amylase induction in embryoless barley half-seeds"
],
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0,
191
... | [
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"id": "IEPA.d132.s319.e0",
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"gibberellin"
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"id": "IEPA.d132.s319.e1",
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"text": [
"alpha-amylase"
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136,
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IEPA.d133 | 10579314 | [
{
"id": "IEPA.d133.s321",
"type": "",
"text": [
"Neurotransmitters and hormones, such as arginine vasopressin (AVP) and bombesin, evoke frequency-modulated repetitive Ca2+ transients in insulin-secreting HIT-T15 cells by binding to receptors linked to phospholipase C (PLC)"
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"id": "IEPA.d133.s321.e0",
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"insulin"
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"id": "IEPA.d133.s321.e1",
"type": "",
"text": [
"phospholipase C"
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203,
... | [] | [] | [] |
IEPA.d134 | 10604763 | [
{
"id": "IEPA.d134.s322",
"type": "",
"text": [
"Isolation and characterization of gibbestatin B, an inhibitor of gibberellin-induced expression of alpha-amylase, and gibbestatin C from streptomycetaes"
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0,
152
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"id": "IEPA.d134.s322.e0",
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"gibberellin"
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65,
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"id": "IEPA.d134.s322.e1",
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"alpha-amylase"
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99,
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IEPA.d137 | 10679516 | [
{
"id": "IEPA.d137.s325",
"type": "",
"text": [
"We previously showed that arginine vasopressin (AVP) stimulates heat shock protein 27 (HSP27) induction through protein kinase C activation in aortic smooth muscle A10 cells"
],
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0,
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... | [
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"id": "IEPA.d137.s325.e0",
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"arginine vasopressin"
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"id": "IEPA.d137.s325.e1",
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"protein kinase C"
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... | [] | [] | [
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] |
IEPA.d138 | 10684630 | [
{
"id": "IEPA.d138.s327",
"type": "",
"text": [
"Insulin-like signaling in yeast: modulation of protein phosphatase 2A, protein kinase A, cAMP-specific phosphodiesterase, and glycosyl-phosphatidylinositol-specific phospholipase C activities"
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0,
191
... | [
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"id": "IEPA.d138.s327.e0",
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"Insulin"
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0,
7
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"id": "IEPA.d138.s327.e1",
"type": "",
"text": [
"phospholipase C"
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165,
1... | [] | [] | [
{
"id": "IEPA.d138.s328.i0",
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{
"id": ... |
IEPA.d139 | 10702765 | [
{
"id": "IEPA.d139.s333",
"type": "",
"text": [
"Leptin and UCP (1 and 2) mRNA levels were determined by reverse transcription-polymerase chain reaction (RT-PCR) methodology in adipose tissue and gastrocnemius muscle"
],
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0,
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... | [
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"Leptin"
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"id": "IEPA.d139.s333.e1",
"type": "",
"text": [
"UCP"
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11,
14
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... | [] | [] | [] |
IEPA.d140 | 10704947 | [
{
"id": "IEPA.d140.s335",
"type": "",
"text": [
"Arginine vasopressin (AVP) and lysophosphatidic acid (LPA) have been shown to stimulate protein kinase C (PKC) and mitogen-activated protein (MAP) kinases and the proliferation of vascular smooth muscle cells"
],
"offsets": [
[
... | [
{
"id": "IEPA.d140.s335.e0",
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"Arginine vasopressin"
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"id": "IEPA.d140.s335.e1",
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"protein kinase C"
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... | [] | [] | [
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{
"id": ... |
IEPA.d141 | 10751197 | [
{
"id": "IEPA.d141.s338",
"type": "",
"text": [
"Tolbutamide and diazoxide modulate phospholipase C-linked Ca(2+) signaling and insulin secretion in beta-cells"
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0,
110
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{
"id": "IEPA.d141.s339",
"type": "",
"text": [
... | [
{
"id": "IEPA.d141.s338.e0",
"type": "",
"text": [
"phospholipase C"
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35,
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{
"id": "IEPA.d141.s338.e1",
"type": "",
"text": [
"insulin"
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79,
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{
"id": "IEPA.d141.s338.i0",
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"id": "IEPA.d141.s339.i0",
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"arg2_id": "IEPA.d141.s339.e2",
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},
{
"id": ... |
IEPA.d143 | 10758829 | [
{
"id": "IEPA.d143.s343",
"type": "",
"text": [
"Oxytocin central injections to intact animals stimulated insulin synthesis and secretion without changing of islets area"
],
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0,
120
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{
"id": "IEPA.d143.s344",
"type": "",
"... | [
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"id": "IEPA.d143.s343.e0",
"type": "",
"text": [
"Oxytocin"
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0,
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"id": "IEPA.d143.s343.e1",
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"insulin"
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57,
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{
"id": "IEPA.d143.s344.i0",
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"arg1_id": "IEPA.d143.s344.e0",
"arg2_id": "IEPA.d143.s344.e1",
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}
] |
IEPA.d144 | 10767942 | [
{
"id": "IEPA.d144.s345",
"type": "",
"text": [
"Hypothalamic neuropeptide Y and its neuroendocrine regulation by leptin"
],
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[
0,
71
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]
}
] | [
{
"id": "IEPA.d144.s345.e0",
"type": "",
"text": [
"neuropeptide Y"
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13,
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"id": "IEPA.d144.s345.e1",
"type": "",
"text": [
"leptin"
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65,
71... | [] | [] | [
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}
] |
IEPA.d146 | 10790161 | [
{
"id": "IEPA.d146.s351",
"type": "",
"text": [
"Ca2+ signalling in rat vascular smooth muscle cells: a role for protein kinase C at physiological vasoconstrictor concentrations of vasopressin"
],
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0,
143
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},
{
"id": "IEPA.d146.s352"... | [
{
"id": "IEPA.d146.s351.e0",
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"protein kinase C"
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64,
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"id": "IEPA.d146.s351.e1",
"type": "",
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"vasopressin"
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132,
... | [] | [] | [
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{
"id": ... |
IEPA.d147 | 10799298 | [
{
"id": "IEPA.d147.s357",
"type": "",
"text": [
"Ten protein kinases have been assayed for their ability to phosphorylate in vitro the recombinant bovine PrP (25-242) (rbPrP)"
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0,
125
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},
{
"id": "IEPA.d147.s358",
"type": "",
... | [
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"id": "IEPA.d147.s357.e0",
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"protein kinases"
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4,
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{
"id": "IEPA.d147.s357.e1",
"type": "",
"text": [
"recombinant bovine PrP"
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[
... | [] | [] | [
{
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] |
IEPA.d148 | 10805498 | [
{
"id": "IEPA.d148.s359",
"type": "",
"text": [
"In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues"
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[
0,
126
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},
{
"id": "IEPA.d148.s360",
"type": "",... | [
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"id": "IEPA.d148.s359.e0",
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"leptin"
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50,
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"id": "IEPA.d148.s359.e1",
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"text": [
"uncoupling protein"
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61,
... | [] | [] | [] |
IEPA.d149 | 10806392 | [
{
"id": "IEPA.d149.s362",
"type": "",
"text": [
"Furthermore, in SN-56/OBR cells both CNTF and leptin produce changes in neurotransmitter and neuropeptide phenotype characteristic of cholinergic neurons, such as an increase in choline acetyltransferase and vasoactive intestinal polypeptide, and a ... | [
{
"id": "IEPA.d149.s362.e0",
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"leptin"
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46,
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"id": "IEPA.d149.s362.e1",
"type": "",
"text": [
"neuropeptide Y"
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261,
2... | [] | [] | [
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"id": "IEPA.d149.s362.i0",
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"arg2_id": "IEPA.d149.s362.e1",
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] |
IEPA.d150 | 10808082 | [
{
"id": "IEPA.d150.s363",
"type": "",
"text": [
"Possible central nervous system (CNS) mechanisms could mediate these responses in that leptin receptors are located on hypothalamic neurons that coexpress neuropeptide-Y (NPY) or proopiomelanocortin (POMC) and both peptides that have been implicated... | [
{
"id": "IEPA.d150.s363.e0",
"type": "",
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"neuropeptide-Y"
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155,
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{
"id": "IEPA.d150.s363.e1",
"type": "",
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"leptin"
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284,
... | [] | [] | [
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}
] |
IEPA.d151 | 10810959 | [
{
"id": "IEPA.d151.s365",
"type": "",
"text": [
"Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women [see comments]"
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0,
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{
"id": "IEPA.d151.s366",
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"text": [... | [
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19,
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"id": "IEPA.d151.s365.e1",
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"neuropeptide Y"
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27,
41... | [] | [] | [
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] |
IEPA.d152 | 10818263 | [
{
"id": "IEPA.d152.s368",
"type": "",
"text": [
"We examined for the first time in young men effects of intravenous injections of NPY (4x50 or 100 microg, n = 9 and 11, respectively, at 22.00, 23.00, 24.00 and 01.00 compared to saline) on the sleep electroencephalogram (EEG; recorded from 23.00 to... | [
{
"id": "IEPA.d152.s368.e0",
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"id": "IEPA.d152.s368.e1",
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"leptin"
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... | [] | [] | [] |
IEPA.d153 | 10821329 | [
{
"id": "IEPA.d153.s369",
"type": "",
"text": [
"Interestingly, both 5-HT and leptin modulate the action of NPY, which may form a part of a common output pathway for the expression of appetite"
],
"offsets": [
[
0,
143
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]
}
] | [
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"id": "IEPA.d153.s369.e0",
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"leptin"
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"id": "IEPA.d153.s369.e1",
"type": "",
"text": [
"NPY"
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59,
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... | [] | [] | [
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}
] |
IEPA.d154 | 10824737 | [
{
"id": "IEPA.d154.s370",
"type": "",
"text": [
"The glycosyl-phosphatidylinositol anchored protein, membrane dipeptidase (EC 3.4.13.19) is released from the surface of 3T3-L1 adipocytes in response to insulin treatment through the action of a phospholipase C"
],
"offsets": [
[
... | [
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"id": "IEPA.d154.s370.e0",
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"text": [
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153,
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"id": "IEPA.d154.s370.e1",
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"text": [
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195,
... | [] | [] | [
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}
] |
IEPA.d155 | 10830302 | [
{
"id": "IEPA.d155.s372",
"type": "",
"text": [
"However, neither progesterone nor insulin increased phosphotyrosine on PLCgamma"
],
"offsets": [
[
0,
79
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]
}
] | [
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"id": "IEPA.d155.s372.e0",
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"id": "IEPA.d155.s372.e1",
"type": "",
"text": [
"PLCgamma"
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71,
79
... | [] | [] | [] |
IEPA.d156 | 10842667 | [
{
"id": "IEPA.d156.s373",
"type": "",
"text": [
"Leptin is a satiety factor which acts within the hypothalamus to decrease the levels of several neuropeptides stimulating food intake (among them, neuropeptide Y [NPY]), while increasing those that inhibit food intake"
],
"offsets": [
... | [
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"id": "IEPA.d156.s373.e1",
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147,
161... | [] | [] | [
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] |
IEPA.d157 | 10845452 | [
{
"id": "IEPA.d157.s374",
"type": "",
"text": [
"We have studied the effects of neomycin, a potent inhibitor of inositol phospholipid-specific phospholipase C (PLC), on the germination of rice seed and the gibberellin-induced expression of alpha-amylase in the aleurone layer and the scutellar tiss... | [
{
"id": "IEPA.d157.s374.e0",
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"id": "IEPA.d157.s374.e1",
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191,
... | [] | [] | [
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{
"id": ... |
IEPA.d158 | 10848532 | [
{
"id": "IEPA.d158.s377",
"type": "",
"text": [
"NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior"
],
"offsets": [
[
0,
98
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]
},
{
"id": "IEPA.d158.s378",
"type": "",
"text": [
"Many st... | [
{
"id": "IEPA.d158.s377.e0",
"type": "",
"text": [
"NPY"
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0,
3
]
],
"normalized": []
},
{
"id": "IEPA.d158.s377.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
4,
10
]
]... | [] | [] | [] |
IEPA.d159 | 10852469 | [
{
"id": "IEPA.d159.s382",
"type": "",
"text": [
"In the fasting state UCP-2 expression correlated inversely with body mass index (r = -0.45; P = 0.026), percent body fat (r = -0.41; P = 0.05), plasma insulin (r = -0.47; P = 0.02), epigastric venous fatty acids (r = -0.45; P = 0.04), and leptin (r ... | [
{
"id": "IEPA.d159.s382.e0",
"type": "",
"text": [
"UCP-2"
],
"offsets": [
[
21,
26
]
],
"normalized": []
},
{
"id": "IEPA.d159.s382.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
239,
245
... | [] | [] | [
{
"id": "IEPA.d159.s382.i0",
"type": "PPI",
"arg1_id": "IEPA.d159.s382.e0",
"arg2_id": "IEPA.d159.s382.e1",
"normalized": []
},
{
"id": "IEPA.d159.s383.i0",
"type": "PPI",
"arg1_id": "IEPA.d159.s383.e0",
"arg2_id": "IEPA.d159.s383.e1",
"normalized": []
},
{
"id": ... |
IEPA.d160 | 10858507 | [
{
"id": "IEPA.d160.s385",
"type": "",
"text": [
"Thus, highly expressed in human adipocytes, the Y(1) receptor sustains the strong antilipolytic effect of NPY and exerts a positive action on leptin secretion"
],
"offsets": [
[
0,
158
]
]
}
] | [
{
"id": "IEPA.d160.s385.e0",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
106,
109
]
],
"normalized": []
},
{
"id": "IEPA.d160.s385.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
142,
148
... | [] | [] | [] |
IEPA.d161 | 10868951 | [
{
"id": "IEPA.d161.s386",
"type": "",
"text": [
"Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion"
],
"offsets": [
... | [
{
"id": "IEPA.d161.s386.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
93,
99
]
],
"normalized": []
},
{
"id": "IEPA.d161.s386.e1",
"type": "",
"text": [
"uncoupling proteins 2"
],
"offsets": [
[
101,
... | [] | [] | [] |
IEPA.d162 | 10868965 | [
{
"id": "IEPA.d162.s390",
"type": "",
"text": [
"We previously reported that adiposity and serum leptin levels increase with age in male F-344xBN rats and that when physiological levels of serum leptin are manipulated by fasting, there is a corresponding reciprocal change in hypothalamic neuropept... | [
{
"id": "IEPA.d162.s390.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "IEPA.d162.s390.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
146,
152
... | [] | [] | [
{
"id": "IEPA.d162.s391.i0",
"type": "PPI",
"arg1_id": "IEPA.d162.s391.e0",
"arg2_id": "IEPA.d162.s391.e1",
"normalized": []
},
{
"id": "IEPA.d162.s393.i0",
"type": "PPI",
"arg1_id": "IEPA.d162.s393.e0",
"arg2_id": "IEPA.d162.s393.e1",
"normalized": []
}
] |
IEPA.d163 | 10875926 | [
{
"id": "IEPA.d163.s395",
"type": "",
"text": [
"C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl-coenzyme A"
],
"offsets": [
[
0,
174
]
]
}
... | [
{
"id": "IEPA.d163.s395.e0",
"type": "",
"text": [
"neuropeptide Y"
],
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[
49,
63
]
],
"normalized": []
},
{
"id": "IEPA.d163.s395.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
99,
10... | [] | [] | [] |
IEPA.d164 | 10878420 | [
{
"id": "IEPA.d164.s396",
"type": "",
"text": [
"The aims of this study were: (1) to assess the effects of maternal undernutrition during pregnancy on adult offspring with regard to growth, body composition and plasma levels of glucose, insulin and corticosterone, and (2) to investigate whether ox... | [
{
"id": "IEPA.d164.s396.e0",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
188,
195
]
],
"normalized": []
},
{
"id": "IEPA.d164.s396.e1",
"type": "",
"text": [
"oxytocin"
],
"offsets": [
[
247,
255
... | [] | [] | [] |
IEPA.d165 | 10879675 | [
{
"id": "IEPA.d165.s397",
"type": "",
"text": [
"Interactions between leptin and NPY affecting lipid mobilization in adipose tissue"
],
"offsets": [
[
0,
82
]
]
},
{
"id": "IEPA.d165.s398",
"type": "",
"text": [
"The aim of the current ... | [
{
"id": "IEPA.d165.s397.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
21,
27
]
],
"normalized": []
},
{
"id": "IEPA.d165.s397.e1",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
32,
35
]
... | [] | [] | [
{
"id": "IEPA.d165.s397.i0",
"type": "PPI",
"arg1_id": "IEPA.d165.s397.e0",
"arg2_id": "IEPA.d165.s397.e1",
"normalized": []
},
{
"id": "IEPA.d165.s401.i0",
"type": "PPI",
"arg1_id": "IEPA.d165.s401.e0",
"arg2_id": "IEPA.d165.s401.e1",
"normalized": []
}
] |
IEPA.d166 | 10898738 | [
{
"id": "IEPA.d166.s402",
"type": "",
"text": [
"The protein kinase C specific inhibitor Go-6983 further enhanced the inhibitory effect of VACM-1 on AVP-stimulated cAMP production"
],
"offsets": [
[
0,
130
]
]
}
] | [
{
"id": "IEPA.d166.s402.e0",
"type": "",
"text": [
"protein kinase C"
],
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[
4,
20
]
],
"normalized": []
},
{
"id": "IEPA.d166.s402.e1",
"type": "",
"text": [
"AVP"
],
"offsets": [
[
100,
103... | [] | [] | [] |
IEPA.d168 | 10909965 | [
{
"id": "IEPA.d168.s404",
"type": "",
"text": [
"Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle"
],
"offsets": [
[
0,
137
]
]
},
{
"id": "IEPA.d168.s405",
... | [
{
"id": "IEPA.d168.s404.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "IEPA.d168.s404.e1",
"type": "",
"text": [
"uncoupling protein-3"
],
"offsets": [
[
92,
... | [] | [] | [
{
"id": "IEPA.d168.s404.i0",
"type": "PPI",
"arg1_id": "IEPA.d168.s404.e0",
"arg2_id": "IEPA.d168.s404.e1",
"normalized": []
},
{
"id": "IEPA.d168.s405.i0",
"type": "PPI",
"arg1_id": "IEPA.d168.s405.e0",
"arg2_id": "IEPA.d168.s405.e1",
"normalized": []
},
{
"id": ... |
IEPA.d169 | 10921449 | [
{
"id": "IEPA.d169.s409",
"type": "",
"text": [
"The body mass index (BMI), leptin, plasma neuropeptide Y (NPY), serotonin, thyroxine (T4), triiodothyronine (T3) and reverse triiodothyronine (rT3) in serum were evaluated for each subject"
],
"offsets": [
[
0,
188
... | [
{
"id": "IEPA.d169.s409.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
27,
33
]
],
"normalized": []
},
{
"id": "IEPA.d169.s409.e1",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
42,
56... | [] | [] | [] |
IEPA.d171 | 10930542 | [
{
"id": "IEPA.d171.s415",
"type": "",
"text": [
"Phospholipase C (PLC) activity was investigated by stimulation of membrane preparations obtained from insulin (beta-TC3)-, somatostatin (Rin 1027-B2)-, and glucagon (INR1-G9)-producing pancreatic cell lines using the non-hydrolyzable GTP analogue GT... | [
{
"id": "IEPA.d171.s415.e0",
"type": "",
"text": [
"Phospholipase C"
],
"offsets": [
[
0,
15
]
],
"normalized": []
},
{
"id": "IEPA.d171.s415.e1",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
102,
... | [] | [] | [] |
IEPA.d172 | 10947866 | [
{
"id": "IEPA.d172.s416",
"type": "",
"text": [
"Therefore, it was examined whether stimulation of Swiss 3T3 cells with insulin causes changes in the subcellular distribution of EGF receptors and phospholipase Cgamma1 that could potentially explain the observed synergy or costimulation."
],
... | [
{
"id": "IEPA.d172.s416.e0",
"type": "",
"text": [
"insulin"
],
"offsets": [
[
71,
78
]
],
"normalized": []
},
{
"id": "IEPA.d172.s416.e1",
"type": "",
"text": [
"phospholipase Cgamma1"
],
"offsets": [
[
147,
... | [] | [] | [
{
"id": "IEPA.d172.s416.i0",
"type": "PPI",
"arg1_id": "IEPA.d172.s416.e0",
"arg2_id": "IEPA.d172.s416.e1",
"normalized": []
},
{
"id": "IEPA.d172.s417.i0",
"type": "PPI",
"arg1_id": "IEPA.d172.s417.e0",
"arg2_id": "IEPA.d172.s417.e1",
"normalized": []
},
{
"id": ... |
IEPA.d173 | 10952979 | [
{
"id": "IEPA.d173.s419",
"type": "",
"text": [
"We have established that the recovery of secreted N1 is increased by the protein kinase C agonists PDBu and PMA in a time- and dose-dependent manner in both cell lines"
],
"offsets": [
[
0,
167
]
]
},
{
... | [
{
"id": "IEPA.d173.s419.e0",
"type": "",
"text": [
"N1"
],
"offsets": [
[
50,
52
]
],
"normalized": []
},
{
"id": "IEPA.d173.s419.e1",
"type": "",
"text": [
"protein kinase C"
],
"offsets": [
[
73,
89
... | [] | [] | [
{
"id": "IEPA.d173.s421.i0",
"type": "PPI",
"arg1_id": "IEPA.d173.s421.e0",
"arg2_id": "IEPA.d173.s421.e1",
"normalized": []
}
] |
IEPA.d174 | 10958819 | [
{
"id": "IEPA.d174.s422",
"type": "",
"text": [
"Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration"
],
"offsets": [
[
0,
166
]
]
},
{
... | [
{
"id": "IEPA.d174.s422.e0",
"type": "",
"text": [
"flavonols"
],
"offsets": [
[
19,
28
]
],
"normalized": []
},
{
"id": "IEPA.d174.s422.e1",
"type": "",
"text": [
"flavones"
],
"offsets": [
[
30,
38
... | [] | [] | [
{
"id": "IEPA.d174.s422.i0",
"type": "PPI",
"arg1_id": "IEPA.d174.s422.e0",
"arg2_id": "IEPA.d174.s422.e3",
"normalized": []
},
{
"id": "IEPA.d174.s422.i1",
"type": "PPI",
"arg1_id": "IEPA.d174.s422.e1",
"arg2_id": "IEPA.d174.s422.e3",
"normalized": []
},
{
"id": ... |
IEPA.d175 | 10967095 | [
{
"id": "IEPA.d175.s424",
"type": "",
"text": [
"Although the above data are consistent with a direct ability of leptin to promote TRH biosynthesis through actions on TRH neurons, addition of a-MSH produced a 3.5 fold increase in TRH biosynthesis and release, whereas NPY treatment suppressed ~3 fo... | [
{
"id": "IEPA.d175.s424.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
64,
70
]
],
"normalized": []
},
{
"id": "IEPA.d175.s424.e1",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
219,
222
]
... | [] | [] | [] |
IEPA.d176 | 10969914 | [
{
"id": "IEPA.d176.s425",
"type": "",
"text": [
"For example, leptin suppresses neuropeptide Y (NPY) expression in the arcuate nucleus"
],
"offsets": [
[
0,
85
]
]
}
] | [
{
"id": "IEPA.d176.s425.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
13,
19
]
],
"normalized": []
},
{
"id": "IEPA.d176.s425.e1",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
31,
45... | [] | [] | [
{
"id": "IEPA.d176.s425.i0",
"type": "PPI",
"arg1_id": "IEPA.d176.s425.e0",
"arg2_id": "IEPA.d176.s425.e1",
"normalized": []
}
] |
IEPA.d177 | 10971807 | [
{
"id": "IEPA.d177.s426",
"type": "",
"text": [
"As expected, in fusion of NPY alone (18 microg/day) augmented food intake (191.6% over the initial control, P < 0.05) and produced a 25.1% weight gain in conjunction with a 10-fold increase in serum leptin concentrations at the end of the 7-day peri... | [
{
"id": "IEPA.d177.s426.e0",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "IEPA.d177.s426.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
199,
205
]
... | [] | [] | [
{
"id": "IEPA.d177.s426.i0",
"type": "PPI",
"arg1_id": "IEPA.d177.s426.e0",
"arg2_id": "IEPA.d177.s426.e1",
"normalized": []
},
{
"id": "IEPA.d177.s427.i0",
"type": "PPI",
"arg1_id": "IEPA.d177.s427.e0",
"arg2_id": "IEPA.d177.s427.e1",
"normalized": []
}
] |
IEPA.d178 | 10988071 | [
{
"id": "IEPA.d178.s429",
"type": "",
"text": [
"A caveolin-1-dependent coupling of PrPc to the tyrosine kinase Fyn was observed"
],
"offsets": [
[
0,
79
]
]
}
] | [
{
"id": "IEPA.d178.s429.e0",
"type": "",
"text": [
"PrPc"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "IEPA.d178.s429.e1",
"type": "",
"text": [
"tyrosine kinase Fyn"
],
"offsets": [
[
47,
... | [] | [] | [
{
"id": "IEPA.d178.s429.i0",
"type": "PPI",
"arg1_id": "IEPA.d178.s429.e0",
"arg2_id": "IEPA.d178.s429.e1",
"normalized": []
}
] |
IEPA.d179 | 10997289 | [
{
"id": "IEPA.d179.s430",
"type": "",
"text": [
"Recently several significant advances have been made in this area, including the identification of the appetite regulating hormone, leptin, and a detailed understanding of its targets in the central nervous system (CNS), such as neuropeptide Y (NPY)... | [
{
"id": "IEPA.d179.s430.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
132,
138
]
],
"normalized": []
},
{
"id": "IEPA.d179.s430.e1",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
229,
... | [] | [] | [
{
"id": "IEPA.d179.s430.i0",
"type": "PPI",
"arg1_id": "IEPA.d179.s430.e0",
"arg2_id": "IEPA.d179.s430.e1",
"normalized": []
}
] |
IEPA.d180 | 10997599 | [
{
"id": "IEPA.d180.s431",
"type": "",
"text": [
"A loop system exists between hypothalamic neuropeptide Y (NPY) and peripheral adipose tissue leptin to maintain normal body homeostasis"
],
"offsets": [
[
0,
135
]
]
},
{
"id": "IEPA.d180.s432",
"t... | [
{
"id": "IEPA.d180.s431.e0",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
42,
56
]
],
"normalized": []
},
{
"id": "IEPA.d180.s431.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
93,
99... | [] | [] | [
{
"id": "IEPA.d180.s431.i0",
"type": "PPI",
"arg1_id": "IEPA.d180.s431.e0",
"arg2_id": "IEPA.d180.s431.e1",
"normalized": []
},
{
"id": "IEPA.d180.s432.i0",
"type": "PPI",
"arg1_id": "IEPA.d180.s432.e0",
"arg2_id": "IEPA.d180.s432.e1",
"normalized": []
},
{
"id": ... |
IEPA.d181 | 10997617 | [
{
"id": "IEPA.d181.s435",
"type": "",
"text": [
"Activity and expression of the three UCP's are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin"
],
"offsets": [
[
0,
148
]
]
}
] | [
{
"id": "IEPA.d181.s435.e0",
"type": "",
"text": [
"UCP"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "IEPA.d181.s435.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
142,
148
]
... | [] | [] | [
{
"id": "IEPA.d181.s435.i0",
"type": "PPI",
"arg1_id": "IEPA.d181.s435.e0",
"arg2_id": "IEPA.d181.s435.e1",
"normalized": []
}
] |
IEPA.d182 | 10997621 | [
{
"id": "IEPA.d182.s436",
"type": "",
"text": [
"The effect of leptin in adult rats appears to be exerted at hypothalamic level by regulating growth hormone releasing hormone (GHRH), somatostatin and neuropeptide Y (NPY)-producing neurones"
],
"offsets": [
[
0,
190
... | [
{
"id": "IEPA.d182.s436.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
14,
20
]
],
"normalized": []
},
{
"id": "IEPA.d182.s436.e1",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
151,
1... | [] | [] | [
{
"id": "IEPA.d182.s436.i0",
"type": "PPI",
"arg1_id": "IEPA.d182.s436.e0",
"arg2_id": "IEPA.d182.s436.e1",
"normalized": []
}
] |
IEPA.d183 | 10997641 | [
{
"id": "IEPA.d183.s437",
"type": "",
"text": [
"Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus"
],
"offsets": [
[
0,
131
]
]
},
{
"id": "IEPA.d183.s438",
"type"... | [
{
"id": "IEPA.d183.s437.e0",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
42,
56
]
],
"normalized": []
},
{
"id": "IEPA.d183.s437.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
61,
67... | [] | [] | [] |
IEPA.d184 | 10997646 | [
{
"id": "IEPA.d184.s441",
"type": "",
"text": [
"These results suggest that T3 may increase UCP family expression independent of leptin action"
],
"offsets": [
[
0,
93
]
]
}
] | [
{
"id": "IEPA.d184.s441.e0",
"type": "",
"text": [
"UCP"
],
"offsets": [
[
43,
46
]
],
"normalized": []
},
{
"id": "IEPA.d184.s441.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
80,
86
]
... | [] | [] | [] |
IEPA.d185 | 10997654 | [
{
"id": "IEPA.d185.s442",
"type": "",
"text": [
"The ARC NPY neurones are stimulated by starvation, probably mediated by falls in circulating leptin and insulin (which both inhibit these neurones), and contribute to the increased hunger in this and other conditions of energy deficit"
],
"o... | [
{
"id": "IEPA.d185.s442.e0",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
8,
11
]
],
"normalized": []
},
{
"id": "IEPA.d185.s442.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
93,
99
]
... | [] | [] | [] |
IEPA.d186 | 11016897 | [
{
"id": "IEPA.d186.s444",
"type": "",
"text": [
"Insulin secretion, inositol phosphate levels, and phospholipase C isozymes in rodent pancreatic islets"
],
"offsets": [
[
0,
102
]
]
},
{
"id": "IEPA.d186.s445",
"type": "",
"text": [
"Th... | [
{
"id": "IEPA.d186.s444.e0",
"type": "",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "IEPA.d186.s444.e1",
"type": "",
"text": [
"phospholipase C"
],
"offsets": [
[
50,
65... | [] | [] | [
{
"id": "IEPA.d186.s445.i0",
"type": "PPI",
"arg1_id": "IEPA.d186.s445.e0",
"arg2_id": "IEPA.d186.s445.e1",
"normalized": []
}
] |
IEPA.d187 | 11021637 | [
{
"id": "IEPA.d187.s446",
"type": "",
"text": [
"Gibbestatin B inhibits the GA-induced expression of alpha-amylase expression in cereal seeds [In Process Citation]"
],
"offsets": [
[
0,
114
]
]
},
{
"id": "IEPA.d187.s447",
"type": "",
"text":... | [
{
"id": "IEPA.d187.s446.e0",
"type": "",
"text": [
"GA"
],
"offsets": [
[
27,
29
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],
"normalized": []
},
{
"id": "IEPA.d187.s446.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
52,
65
... | [] | [] | [
{
"id": "IEPA.d187.s446.i0",
"type": "PPI",
"arg1_id": "IEPA.d187.s446.e0",
"arg2_id": "IEPA.d187.s446.e1",
"normalized": []
},
{
"id": "IEPA.d187.s447.i0",
"type": "PPI",
"arg1_id": "IEPA.d187.s447.e0",
"arg2_id": "IEPA.d187.s447.e1",
"normalized": []
},
{
"id": ... |
IEPA.d188 | 11024558 | [
{
"id": "IEPA.d188.s451",
"type": "",
"text": [
"We also determined whether well known hypothalamic neuropeptide targets, e.g. neuropeptide Y (NPY), proopiomelanocortin (POMC), agouti-related peptide (AGRP) and cocaine and amphetamine-regulated transcript (CART) were regulated in a pattern consist... | [
{
"id": "IEPA.d188.s451.e0",
"type": "",
"text": [
"neuropeptide Y"
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78,
92
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],
"normalized": []
},
{
"id": "IEPA.d188.s451.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
295,
3... | [] | [] | [
{
"id": "IEPA.d188.s451.i0",
"type": "PPI",
"arg1_id": "IEPA.d188.s451.e0",
"arg2_id": "IEPA.d188.s451.e1",
"normalized": []
},
{
"id": "IEPA.d188.s452.i0",
"type": "PPI",
"arg1_id": "IEPA.d188.s452.e0",
"arg2_id": "IEPA.d188.s452.e1",
"normalized": []
}
] |
IEPA.d190 | 11024560 | [
{
"id": "IEPA.d190.s454",
"type": "",
"text": [
"Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y [In Process Citation]"
],
"offsets": [
[
... | [
{
"id": "IEPA.d190.s454.e0",
"type": "",
"text": [
"Leptin"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "IEPA.d190.s454.e1",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
179,
193... | [] | [] | [
{
"id": "IEPA.d190.s454.i0",
"type": "PPI",
"arg1_id": "IEPA.d190.s454.e0",
"arg2_id": "IEPA.d190.s454.e1",
"normalized": []
},
{
"id": "IEPA.d190.s455.i0",
"type": "PPI",
"arg1_id": "IEPA.d190.s455.e0",
"arg2_id": "IEPA.d190.s455.e1",
"normalized": []
}
] |
IEPA.d191 | 11024567 | [
{
"id": "IEPA.d191.s459",
"type": "",
"text": [
"Similarly, central leptin treatment also had a greater effect in suppressing hypothalamic NPY mRNA expression in young (-23+/-4%) than in old (-8+/-4%) rats compared with their age-matched pair-fed treated rats"
],
"offsets": [
[
... | [
{
"id": "IEPA.d191.s459.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
19,
25
]
],
"normalized": []
},
{
"id": "IEPA.d191.s459.e1",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
90,
93
]
... | [] | [] | [
{
"id": "IEPA.d191.s459.i0",
"type": "PPI",
"arg1_id": "IEPA.d191.s459.e0",
"arg2_id": "IEPA.d191.s459.e1",
"normalized": []
}
] |
IEPA.d192 | 11027362 | [
{
"id": "IEPA.d192.s460",
"type": "",
"text": [
"Compared with the wild type, GA induction of alpha-amylase activity in aleurone cells of d1 was greatly reduced"
],
"offsets": [
[
0,
111
]
]
},
{
"id": "IEPA.d192.s461",
"type": "",
"text": [
... | [
{
"id": "IEPA.d192.s460.e0",
"type": "",
"text": [
"GA"
],
"offsets": [
[
29,
31
]
],
"normalized": []
},
{
"id": "IEPA.d192.s460.e1",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
45,
58
... | [] | [] | [
{
"id": "IEPA.d192.s460.i0",
"type": "PPI",
"arg1_id": "IEPA.d192.s460.e0",
"arg2_id": "IEPA.d192.s460.e1",
"normalized": []
},
{
"id": "IEPA.d192.s461.i0",
"type": "PPI",
"arg1_id": "IEPA.d192.s461.e0",
"arg2_id": "IEPA.d192.s461.e1",
"normalized": []
},
{
"id": ... |
IEPA.d193 | 11033311 | [
{
"id": "IEPA.d193.s464",
"type": "",
"text": [
"Finally, recent evidences suggest that melanocortins could be involved in mediating the effects of leptin, and in controlling the expression of neuropeptide Y (NPY)"
],
"offsets": [
[
0,
164
]
]
}
] | [
{
"id": "IEPA.d193.s464.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
99,
105
]
],
"normalized": []
},
{
"id": "IEPA.d193.s464.e1",
"type": "",
"text": [
"neuropeptide Y"
],
"offsets": [
[
144,
... | [] | [] | [] |
IEPA.d194 | 11042115 | [
{
"id": "IEPA.d194.s465",
"type": "",
"text": [
"Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase Cgamma and protein kinase Calpha signalling cascade."
],
"offsets": [
[
0,
181
]
... | [
{
"id": "IEPA.d194.s465.e0",
"type": "",
"text": [
"Insulin"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "IEPA.d194.s465.e1",
"type": "",
"text": [
"phospholipase Cgamma"
],
"offsets": [
[
115,
... | [] | [] | [
{
"id": "IEPA.d194.s465.i0",
"type": "PPI",
"arg1_id": "IEPA.d194.s465.e0",
"arg2_id": "IEPA.d194.s465.e1",
"normalized": []
},
{
"id": "IEPA.d194.s468.i0",
"type": "PPI",
"arg1_id": "IEPA.d194.s468.e0",
"arg2_id": "IEPA.d194.s468.e1",
"normalized": []
}
] |
IEPA.d196 | 11054597 | [
{
"id": "IEPA.d196.s476",
"type": "",
"text": [
"Both receive information about the nutritional status and the level of energy storage through insulin and leptin signaling mediated by specific receptors located on POMC and NPY neurons present predominantly in the arcuate nucleus (ARC)."
],
... | [
{
"id": "IEPA.d196.s476.e0",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
106,
112
]
],
"normalized": []
},
{
"id": "IEPA.d196.s476.e1",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
174,
177
... | [] | [] | [] |
IEPA.d197 | 11062072 | [
{
"id": "IEPA.d197.s478",
"type": "",
"text": [
"Bovine prion protein as a modulator of protein kinase CK2"
],
"offsets": [
[
0,
57
]
]
},
{
"id": "IEPA.d197.s479",
"type": "",
"text": [
"On the basis of far-Western blot and plasmon res... | [
{
"id": "IEPA.d197.s478.e0",
"type": "",
"text": [
"Bovine prion protein"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "IEPA.d197.s478.e1",
"type": "",
"text": [
"protein kinase CK2"
],
"offsets": [
[
... | [] | [] | [
{
"id": "IEPA.d197.s478.i0",
"type": "PPI",
"arg1_id": "IEPA.d197.s478.e0",
"arg2_id": "IEPA.d197.s478.e1",
"normalized": []
},
{
"id": "IEPA.d197.s479.i0",
"type": "PPI",
"arg1_id": "IEPA.d197.s479.e0",
"arg2_id": "IEPA.d197.s479.e1",
"normalized": []
},
{
"id": ... |
IEPA.d198 | 11068095 | [
{
"id": "IEPA.d198.s483",
"type": "",
"text": [
"Arcuate nucleus NPY mRNA increased in rats given protein-free diet, correlating with leptin rather than decreased feeding"
],
"offsets": [
[
0,
121
]
]
}
] | [
{
"id": "IEPA.d198.s483.e0",
"type": "",
"text": [
"NPY"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "IEPA.d198.s483.e1",
"type": "",
"text": [
"leptin"
],
"offsets": [
[
85,
91
]
... | [] | [] | [
{
"id": "IEPA.d198.s483.i0",
"type": "PPI",
"arg1_id": "IEPA.d198.s483.e0",
"arg2_id": "IEPA.d198.s483.e1",
"normalized": []
}
] |
IEPA.d199 | 11094982 | [
{
"id": "IEPA.d199.s484",
"type": "",
"text": [
"The induction of alpha-amylase triggered by gibberellic acid in barley embryos is repressed by sugars"
],
"offsets": [
[
0,
101
]
]
},
{
"id": "IEPA.d199.s485",
"type": "",
"text": [
"Our... | [
{
"id": "IEPA.d199.s484.e0",
"type": "",
"text": [
"alpha-amylase"
],
"offsets": [
[
17,
30
]
],
"normalized": []
},
{
"id": "IEPA.d199.s484.e1",
"type": "",
"text": [
"gibberellic acid"
],
"offsets": [
[
44,
... | [] | [] | [
{
"id": "IEPA.d199.s484.i0",
"type": "PPI",
"arg1_id": "IEPA.d199.s484.e0",
"arg2_id": "IEPA.d199.s484.e1",
"normalized": []
}
] |
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