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26,233,553 | Are non-absorbable sutures associated with lower recurrence rates in laparoscopic percutaneous inguinal hernia ligation? | Laparoscopic hernia repair with percutaneous ligation of the patent processes vaginalis is a minimally invasive alternative to open inguinal herniorrhaphy in children. With the camera port concealed at the umbilicus, this technique offers an excellent cosmetic result. It is also faster than the traditional laparoscopic... | Our review of consecutive hernia repairs using the single port percutaneous ligation revealed a significantly higher recurrent hernia rate with absorbable (26%) versus non-absorbable (4%) suture. This finding remained significant in a logistic regression model irregardless of number of sutures placed, age, and weight. ... |
20,839,011 | Do depressive symptoms during the first chemotherapy cycle predict mortality in patients with advanced non-small cell lung cancer? | Depressive symptoms are commonly experienced by cancer patients, especially those with advanced disease. The link between depression and survival outcome in cancer patients has received increasing attention. The purpose of this study was to determine, after adjusting the known covariates, whether the depressive symptom... | The finding supports that depressive symptoms at the early phase of treatment can predict shorter survival in patients with advanced NSCLC. |
26,987,051 | Do utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant? | The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with contralateral acoustic hearing and the electrical stimulation provided by the cochlear implant. Measures of spatial and non-spatial hearing abilities were obtained to... | Access to bilateral acoustic hearing after cochlear implantation provides significant benefit on a range of functional measures. |
23,563,835 | Tetracycline and trimethoprim/sulfamethoxazole at clinical laboratory: can they help to characterize Staphylococcus aureus carrying different SCCmec types? | Methicillin-resistant Staphylococcus aureus (MRSA) can be difficult to detect at the clinical practice. We analyzed 140 MRSA isolates from inpatients to correlate the antimicrobial susceptibility with the SCCmec types. Type III (n = 63) isolates were more resistant to ciprofloxacin, clindamycin, cloramphenicol, erythro... | In regions where these SCCmec types are prevalent, the detection of specific resistant phenotypes could help to predict them, mainly when there are no technical conditions to SCCmec typing. |
27,390,994 | Is post-operative atrial fibrillation associated with a pre-existing structural and electrical substrate in human right atrial myocardium? | Post-operative atrial fibrillation (POAF) is a major health economic burden. However, the precise mechanisms in POAF remain unclear. In other forms of AF, sites of high dominant frequency (DF) in sinus rhythm (SR) may harbour 'AF nests'. We studied AF inducibility in relation to substrate changes using epicardial elect... | Human atrial electrograms prolong and reduce in amplitude in induced peri-operative AF vs. NSR or pacing. In those sustaining AF, high DF sites in NSR may indicate 'AF nests'. This electrical remodelling is accompanied by structural remodelling with altered expression of cardiomyocyte calcium handling detectable before... |
8,905,601 | Is estrogen deprivation , rather than age , responsible for the poor lipid profile and carbohydrate metabolism in women? | The protective effect of estrogen against cardiovascular diseases (CVD) in women disappears after menopause. However, it is not clear whether the change in risk factors after menopause is related to aging or estrogen deprivation. To assess the risks for CVD and the contribution of aging in estrogen-deprived women. Fort... | Risk factors for CVD are related to estrogen deprivation. Aging does not have an important impact on CVD within the age range of this study group. |
16,096,461 | Does delayed ascorbate bolus protect against maldistribution of microvascular blood flow in septic rat skeletal muscle? | Although early administration of ascorbate has been shown to protect against the microvascular dysfunction in sepsis, it is not clear if a delayed introduction of ascorbate also yields beneficial effects. The main objective was to determine the therapeutic window for treatment of an animal model of sepsis with bolus in... | Despite volume resuscitation, the present model of sepsis resulted in maldistribution of capillary blood flow within 24 hrs and hypotension within 48 hrs. Our finding that intravenous bolus of ascorbate can protect against these deficits even if delayed 6-24 hrs after the septic insult shows, for the first time, that a... |
9,872,613 | Diagnosis of gluten-sensitive enteropathy: is exclusive reliance on histology appropriate? | Coeliac disease is a prevalent disorder but frequently remains undiagnosed because of varied modes of clinical presentation. In this study, methods for the detection of coeliac disease were evaluated in a clinical practice setting. Small intestinal histology, IgA anti-endomysial and IgG anti-gliadin antibody tests were... | In unselected patients attending a gastroenterology clinic, small bowel histology and endomysial antibody serology show similar predictive value in the diagnosis of coeliac disease. These results emphasize that a combination of clinical, histological and serological criteria are required for effective diagnosis of this... |
21,362,305 | Does dexamethasone protect airway epithelial cell line NCI-H292 against lipopolysaccharide induced endoplasmic reticulum stress and apoptosis? | Endoplasmic reticulum (ER) stress and ER stress-mediated apoptosis were reported to be involved in the pathogenesis of several diseases. In a recent study, it was reported that the ER stress pathway was activated in the lungs of lipopolysaccharide (LPS)-treated mice. It was also found that the C/EBP homologous protein ... | LPS may activate ER stress through the overexpression of MUC5AC. Dexamethasone may protect human airway epithelial cells against ER stress-related apoptosis by attenuating the overload of MUC5AC. |
20,809,923 | Does multi-locus sequence typing of Salmonella enterica serovar Typhimurium isolates from wild birds in northern England suggest host-adapted strain? | Recent studies have suggested that Salmonella Typhimurium strains associated with mortality in UK garden birds are significantly different from strains that cause disease in humans and livestock and that wild bird strains may be host adapted. However, without further genomic characterization of these strains, it is not... | Results of MLST analysis suggest that there is a predominant strain of Salm. Typhimurium circulating among garden bird populations in the United Kingdom, which is rarely detected in other species, supporting the hypothesis that this strain is host adapted. |
23,575,307 | Is mir-17-92 cluster required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts? | Cardiomyocytes in adult mammalian hearts are terminally differentiated cells that have exited from the cell cycle and lost most of their proliferative capacity. Death of mature cardiomyocytes in pathological cardiac conditions and the lack of regeneration capacity of adult hearts are primary causes of heart failure and... | Our studies therefore identify miR-17-92 as a critical regulator of cardiomyocyte proliferation, and suggest this cluster of microRNAs could become therapeutic targets for cardiac repair and heart regeneration. |
18,474,537 | Is stroke volume increase to exercise in chronic obstructive pulmonary disease limited by increased pulmonary artery pressure? | This study was designed to investigate the mechanisms by which the right ventricle is able to increase stroke volume (SV) during exercise in chronic obstructive pulmonary disease (COPD). A second aim was to determine whether resting pulmonary artery pressure (Ppa) is predictive of exercise SV. 16 COPD patients (GOLD st... | As a consequence of unaltered pulmonary vascular resistance to exercise in COPD patients, Ppa increases and SV response to exercise is limited and results from an increased preload only. Ppa at rest predicts exercise SV. |
25,784,095 | Does symptomatic Reactivation of HSV Infection correlate with Decreased Serum Levels of TNF-α? | Herpes simplex viruses (HSV) are human pathogens that establish lytic and latent infections. Reactivation from latency occurs intermittently, which represents a life-long source for recurrent infection. The role of immune factors in the control of recurrent symptomatic HSV lesions is complex and the exact role of cytok... | The decreased level of TNF-α and increased levels of IgG in individuals with a history of symptomatic reactivation of HSV infection is suggestive of a probable shift in favor of the Th2 immune response. |
16,322,483 | Is regular aspirin-use preceding the onset of primary intracerebral hemorrhage an independent predictor for death? | Hematoma volume and impaired level of consciousness are the most potent predictors of outcome after spontaneous intracerebral hemorrhage (ICH). The effect of preceding aspirin-use on outcome after ICH is poorly investigated. We investigated short-term mortality and hematoma enlargement in subjects with ICH to find the ... | We observed poor short-term outcomes and increased mortality, probably attributable to rapid enlargement of hematomas, in the subjects with ICH who had been taking regularly moderate doses of aspirin (median 250 mg) immediately before the onset of the stroke. |
26,000,253 | Do isotopic evidence for dietary niche overlap between barking deer and four-horned antelope in Nepal? | Morphologically similar sympatric species may have a high degree of niche overlap. Barking deer Muntiacus vaginalis and four-horned antelope Tetracerus quadricornis are solitary ungulates of the Indian sub-continent. Limited information is available regarding their trophic ecology, particularly of the endemic four-horn... | Barking deer and four-horned antelope both are browsers; their dietary sources overlapped during monsoon but differed during the dry season. Conservation actions focused on resource management during the dry season to reduce food scarcity and competition over limited resources is likely to be the most effective. |
23,756,862 | Are both STAT1 and STAT3 favourable prognostic determinants in colorectal carcinoma? | Aberrant activities of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathways have been implicated in the development and spread of various cancer entities, among them colorectal carcinoma (CRC). Transcription factors STAT3 and STAT1, both downstream effectors of interleukin (IL)... | By multivariate data analysis, we could show that STAT3 expression and activity constitutes an independent favourable prognostic marker for CRC. |
12,822,719 | Do physicians ' reports of their experience with health plan care management practices? | To determine the availability of care management practices in various practice settings, the degree to which physicians report that these practices are useful, and whether physicians' reports vary by their relationships with health plans. Cross-sectional survey. In 2001, we surveyed generalist and specialist physicians... | The stronger a physician's relationship with a health plan, the more positive the physician's experience with care management practices and policies was. The concordance between the types of available practices and physicians' ratings suggests that health plans and physicians agree about how to improve the quality of c... |
21,996,703 | Does imatinib mesylate-incorporated nanoparticle-eluting stent attenuate in-stent neointimal formation in porcine coronary arteries? | The use of currently marketed drug-eluting stents (DES) presents safety concerns, including an increased risk for late thrombosis in the range of 0.6% per year in patients, including acute coronary syndrome, which is thought to result from delayed endothelial healing effects. A new DES system targeting vascular smooth ... | These data suggest that suppression of neointima formation by a imatinib-NP-eluting stent holds promise as a molecular-targeting NP delivery system for preventing in-stent restenosis. |
21,799,167 | Does serum low-density lipoprotein cholesterol level predict hematoma growth and clinical outcome after acute intracerebral hemorrhage? | Lower serum low-density lipoprotein cholesterol (LDL-C) levels have been associated with increased risk of death after intracerebral hemorrhage (ICH). Nevertheless, their link with hematoma growth (HG) is unknown. Therefore, we aimed to investigate the relationship between LDL-C levels, HG, and clinical outcome in pati... | Lower serum LDL-C level independently predicts HG, early neurological deterioration, and 3-month mortality after acute ICH. |
23,689,964 | Deep partial rotator cuff tear: transtendon repair or tear completion and repair? | The purpose of this study is to compare the clinical and subjective difference between transtendon repair or complete/repair in two homogeneous groups of patients affected by deep partial articular supraspinatus tear. Seventy-four patients were randomized in two groups of 37 patients each. The first group (A) was treat... | Both repairing techniques of deep partial supraspinatus tear provide good results in terms of function and pain. There were no statistically significant differences between the two techniques. |
27,056,206 | Do microRNA-206 and its down-regulation of Wilms'Tumor-1 dictate podocyte health in adriamycin-induced nephropathy? | Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease characterized by destabilization of podocyte foot processes. Emerging evidence suggests that microRNAs play crucial roles in podocyte homeostasis. The aim of the present study was to determine the role of miR-206 in podocyte injury an... | Over expression of miR-206 promotes podocyte injury via downregulation of WT1, which provides a new pathogenic mechanism for FSGS and miR-206 may be a potential therapeutic target. |
10,622,014 | Are postal questionnaire surveys of reported activity valid? | Postal questionnaire surveys are commonly used in general practice and often ask about self-reported activity. The validity of this approach is unknown.AIM: To explore the criterion validity of questions asking about self-reported activity in a self-completion questionnaire. A comparison was made between (a) the self-r... | There is a variable relationship between what responders report that they do in self-completion questionnaires, and what they actually do as judged by the contents of their patients' medical records. In the absence of prior, knowledge of the validity of questions on reported activity, or of concurrent attempts to estab... |
26,843,232 | Can conclusions drawn from phantom-based image noise assessments be generalized to in vivo studies for the nonlinear model-based iterative reconstruction method? | Phantom-based objective image quality assessment methods are widely used in the medical physics community. For a filtered backprojection (FBP) reconstruction-based linear or quasilinear imaging system, the use of this methodology is well justified. Many key image quality metrics acquired with phantom studies can be dir... | Despite the nonlinear nature of the MBIR method, the power-law relationship, σ(2) ∝ (mAs)(-0.4), found from phantom studies can be applied to in vivo animal and human subject studies. |
15,181,979 | Are neuropeptide Y and Y2-receptor involved in development of diabetic retinopathy and retinal neovascularization? | Neuropeptide Y is a sympathetic neurotransmitter, a potent endothelium-derived angiogenic factor and a vascular mitogen. We have studied the role of the functional leucine7 to proline7 polymorphism of the signal peptide region of preproneuropeptide Y (prepro-NPY) as a genetic susceptibility factor for diabetic retinopa... | NPY and Y2-receptor play important roles in diabetic retinopathy and retinal neovascularization and are thus potential new targets for drug molecules for treatment of retinopathy. |
17,412,519 | Is postmenopause associated with recurrence of differentiated papillary thyroid carcinoma? | Differentiated papillary thyroid carcinoma (D-PTC) is the most common malignancy arising in the thyroid gland. There are gender differences in the incidence of PTC being mainly observed in females. Low-risk groups consisted of men younger than 40-year-old and women younger than 50-year-old, whereas the high-risk group ... | Postmenopause is an adverse factor for tumor evolution in women with D-PTC and is associated with EGFR expression. It's introduction in thyroid tumor stratification could be a fine tuning in predicting papillary thyroid carcinoma behavior. |
24,488,828 | Does health-related quality of life worsen disproportionately to objective signs of psoriasis after withdrawal of adalimumab therapy? | Health-related quality of life (HRQoL) is an important part of the clinical assessment and management of psoriasis. Few studies have investigated the effects of withdrawing treatment on the relationship between HRQoL and objective clinical manifestations of psoriasis. This post hoc subanalysis of a clinical trial (REVE... | Discontinuing therapy in patients who initially responded to treatment, as seen in this analysis with adalimumab, disproportionately worsened patient-reported HRQoL relative to the worsening of PASI. |
19,110,807 | Are long-term safety and efficacy observed after implantation of Zotarolimus-Eluting stent in real-world clinical practice? | Zotarolimus-eluting stents (ZESs) have been shown to be safe and effective in randomised trials. We sought to report the clinical outcomes after implantation of ZES in real-world clinical practice. ZES have been approved for clinical use in Singapore since April 2005. Until December 31, 2007, a total of 219 patients ha... | In this real-world clinical experience, ZES was associated with a low incidence of adverse cardiac events at a medium follow-up of one and half years. |
16,008,221 | Do effects of aerosolized class C fly ash in weanling goats? | To determine effects of repeated aerosol exposures to fly ash dust on respiratory tracts of tent-confined goats. 12 weanling Boer-Spanish crossbred goats. Goats were randomly assigned to 2 groups: fly ash treatment group (principal goats, n = 6) or control group (control goats, 6). Aerosolized fly ash dust was provided... | An increase in atelectatic lung lesions was observed in principal goats, compared with control goats; however, overall, fly ash dust effects were nontoxic. |
27,022,061 | Does precollegiate Knee Surgery predict Subsequent Injury Requiring Surgery in NCAA Athletes? | The effect of precollegiate orthopaedic surgery on injury risk in the elite collegiate athlete is unknown. To (1) assess the relationship between precollegiate surgery and subsequent injury requiring surgery in National Collegiate Athletic Association (NCAA) Division I athletes at a single institution and (2) compare t... | Precollegiate knee surgery in the Division I athlete is associated with subsequent injury requiring surgery in college. Athletes with a history of precollegiate surgery are at higher risk of subsequent surgery in their ipsilateral extremity compared with other extremities. |
16,403,672 | Do neuromagnetic responses to vowels vs. tones reveal hemispheric lateralization? | To evaluate whether a simple auditory paradigm could demonstrate a difference in cortical lateralization between right- and left-handed subjects. Such information would be important for later development of clinical noninvasive tests of hemispheric language dominance in candidates for brain surgery. Healthy subjects (1... | Our results demonstrate difference in hemispheric dominance for processing of vowels between right-handed and left-handed subjects. This difference resembles language lateralization suggested by previous invasive studies as well as by anatomical and functional comparisons in left- and right-handed subjects. |
20,223,095 | Does prior use of angiotensin-converting enzyme inhibitors affect outcome in patients with intracerebral hemorrhage? | Angiotensin-converting enzyme inhibitors (ACEI) exert protective effects in patients with stroke but their effects remain unknown in patients with intracerebral hemorrhage (ICH). We recruited consecutive patients with acute ICH and analysed pre-admission demographic variables and drug therapy as well as clinical and ra... | In conclusion, our study does not support a possible neuroprotective effect for ACEI use prior to the occurrence of ICH. |
26,676,089 | Does anterolateral Portal be Less Painful than Superolateral Portal in Knee Intra-Articular Injection? | Intra-articular knee injections are commonly performed in clinical practice for treating various knee joint disorders such as osteoarthritis and rheumatoid arthritis. When selecting the portal for injection, not only intra-articular needle accuracy but also procedural pain should be taken into consideration. The purpos... | We recommend the use of anterolateral portal for intra-articular knee injection as it provokes less pain and comparably short-term pain relief than the superolateral portal. |
18,340,101 | Do whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21? | Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes. Given that stroke is a common complication after myocardial infarction, we investigated if the same SNPs were associated with ischemic ... | These data are important for 3 reasons: first, they suggest a genetic association for stroke; second, they suggest that this association shares pathogenic mechanisms with heart disease and diabetes; and third, they illustrate, that public release of data can facilitate rapid risk locus discovery. |
19,126,299 | Does andrographolide inhibit growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis? | The growth inhibiting potential of andrographolide was evaluated in three acute promyelocytic leukaemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2). In elucidating the mechanisms of growth inhibition, a special emphasis was placed on assessing the induction of differentiation and a... | Taken together, these results suggest andrographolide and its derivatives, apparently with a novel cell differentiating mechanism and with ability to induce apoptosis, might be beneficial in the treatment of primary and ATRA-resistant acute promyelocytic leukaemia. |
12,488,271 | Do epilepsy patients treated with vigabatrin exhibit reduced ocular blood flow? | Reduced cerebral blood flow and decreased glucose metabolism have been identified in epilepsy patients receiving vigabatrin. It is likely that such a change may extend to the eye and may be linked to previously reported irreversible visual field defects. The aim of this study was to determine whether patients who have ... | A significant reduction in POBF and PA is apparent in epilepsy patients treated with AEDs when compared to normal subjects. A further reduction in POBF and PA is apparent between vigabatrin treated and conventionally treated patients. The reduction in ocular perfusion, which is more pronounced in patients previously tr... |
18,767,916 | Rural placements in Tasmania: do experiential placements and background influence undergraduate health science student's attitudes toward rural practice? | Each year growing numbers of undergraduate health science students, from a variety of disciplines, participate in a University of Tasmania Department of Rural Health supported rural placement program in Tasmania. This study aimed to investigate the influence rural placement and rural background had on students' intenti... | The value of rural placements as a method for increasing health science students' intentionality to take up rural practice as a positive and viable career option is considerable. |
24,138,138 | Is airway hyperresponsiveness associated with airway remodeling but not inflammation in aging Cav1-/- mice? | Airway inflammation and airway remodeling are the key contributors to airway hyperresponsiveness (AHR), a characteristic feature of asthma. Both processes are regulated by Transforming Growth Factor (TGF)-β. Caveolin 1 (Cav1) is a membrane bound protein that binds to a variety of receptor and signaling proteins, includ... | A lack of Cav1 contributed to the thickness of the subepithelial layer in mice as they aged resulting in an increase in AHR independent of inflammation, demonstrating the important contribution of airway structural changes to AHR. In addition, age in the Cav1-/- mice is a contributing factor to airway remodeling in the... |
8,039,039 | Do the reticulocyte maturation fractions and bone marrow reticulocyte count further help the classification of anemias? | Reticulocyte count plays a major role in anemic evaluation. The conventional method done by the manual supravital staining cannot subclassify the group of less than 2% of corrected reticulocyte count. The newly-developed flow cytometer provides different maturation fractions by measuring its fluorescent intensity. The ... | The automated reticulocyte count with maturation fractions helps classify anemias, particularly for those with low reticulocyte count by the manual method. |
24,815,141 | Does inhibition of inducible nitric oxide synthesis ameliorate liver ischemia and reperfusion injury induced transient increase in arterial stiffness? | Hemodynamic instability is a frequent scenario after reperfusion of ischemic liver due to major liver resection and liver transplantation. Previously, we showed that liver ischemia/reperfusion (I/R) injury induced increases in reactive oxygen/nitrogen species and inducible nitric oxide synthase (iNOS) expression impair... | I/R-induced arterial stiffening was strongly associated with increased systemic inflammation. Comparable effects with treatments of 1,400W and L-NAME suggested that iNOS plays a dominant role in I/R-induced transient arterial stiffening. |
26,333,305 | Is dll4 in the DCs isolated from OVA-sensitized mice involved in Th17 differentiation inhibition by 1,25-dihydroxyvitamin D3 in vitro? | T helper 17 cell (Th17) cells play an important role in neutrophilic asthma, and 1,25(OH)2D3 has been reported to modulate the proliferation and differentiation of T cells. In this study, we examined the effects of 1,25(OH)2D3 on the dendritic cell (DC)-mediated regulation of Th17differentiation from OVA-sensitized mic... | These result suggest that Dll4 in the DCs isolated from OVA-sensitized mice is involved in Th17 differentiation inhibition by 1,25(OH)2D3. |
26,016,886 | Does novel keratin preparation support growth and differentiation of odontoblast-like cells? | To fabricate a keratin hydrogel, characterize its functionality as a biomaterial and investigate the effects of keratin on growth and differentiation of odontoblast-like cells. Keratins were extracted from sheep wool using a well-established technique. The extracted proteins were purified by dialysis, quantified by gel... | The presence of keratin enhanced odontoblast cell behaviour. Keratin hydrogels may be a potential scaffold for pulp-dentine regen-eration. |
21,802,767 | Does serum killing of Ureaplasma parvum show serovar-determined susceptibility for normal individuals and common variable immuno-deficiency patients? | Many Gram-negative bacteria, unlike Gram-positive, are directly lysed by complement. Ureaplasma can cause septic arthritis and meningitis in immunocompromised individuals and induce premature birth. Ureaplasma has no cell wall, cannot be Gram-stain classified and its serum susceptibility is unknown. Survival of Ureapla... | Only the classical complement pathway mediated Ureaplasma-cidal activity, sometimes in the absence of observable immunoblot reactive bands. |
14,993,575 | Can we predict which children with clinically suspected pneumonia will have the presence of focal infiltrates on chest radiographs? | To determine predictive factors for the presence of focal infiltrates in children with clinically suspected pneumonia in a pediatric emergency department. Children (1-16 years) with clinically suspected pneumonia were studied prospectively. The presenting features were compared between the children with and without foc... | Multiple predictive factors for children with suspected pneumonia have been identified. Patients with focal infiltrates were more likely in our study to have a history of fever, tachypnea, increased heart rate, retractions, grunting, crackles, or decreased breath sounds. A multivariate prediction rule shows promise for... |
14,662,714 | Does vagal nerve stimulation markedly improve long-term survival after chronic heart failure in rats? | Diminished cardiac vagal activity and higher heart rate predict a high mortality rate of chronic heart failure (CHF) after myocardial infarction. We investigated the effects of chronic electrical stimulation of the vagus nerve on cardiac remodeling and long-term survival in an animal model of CHF after large myocardial... | Vagal nerve stimulation markedly improved the long-term survival of CHF rats through the prevention of pumping failure and cardiac remodeling. |
23,042,313 | Do statins influence platelet reactivity on acetylsalicylic acid therapy in patients with type 2 diabetes? | Type 2 diabetes (T2DM) patients are at increased risk of cardiovascular events despite long-term acetylsalicylic acid (ASA) therapy. This study was performed to establish the prevalence of high platelet reactivity (HPR) on ASA in T2DM and to identify its predictors. The study included 185 T2DM on chronic ASA therapy an... | Our study provides indirect evidence that the beneficial effect of statins on platelet activity may be related to their non-lipid-mediated, pleiotropic mechanisms of action. This might have been partly related to decreased platelet reactivity in patients receiving statin therapy. In our study in patients with T2DM, pla... |
17,553,035 | Is hairdressing associated with scalp disease in African schoolchildren? | Anecdotal reports suggest that certain disorders are common in African hair and may be associated with hairstyles. A cross-sectional study of 1042 schoolchildren was performed to test this hypothesis. A questionnaire was administered and scalp examinations performed, after ethics approval. Participants included 45% boy... | We found associations between hairstyle and disease in our population of schoolchildren. AKN appears to be associated with frequently cut natural hair and TA with relaxed hair. These associations need further study for purposes of disease prevention. |
17,673,697 | Does cathepsin S deficiency confer protection from neonatal hyperoxia-induced lung injury? | Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. In... | Cathepsin S deficiency improves alveolarization, and attenuates macrophage influx and fibroproliferative changes in hyperoxia-induced neonatal mouse lung injury. |
24,145,577 | Is eR stress in rodent islets of Langerhans concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes? | The objective of this study was to determine whether ER stress correlates with β-cell dysfunction in obesity-associated diabetes. Quantitative RT-PCR and western blot analysis were used to investigate changes in the expression of markers of ER stress, the unfolded protein response (UPR) and β-cell function in islets is... | These results provide evidence that obesity-induced activation of the UPR is an adaptive response for increasing the ER folding capacity to meet the increased demand for insulin. As ER stress is not exacerbated in high-fat-diet-induced diabetes, we suggest that failure of the islet to mount an effective adaptive UPR in... |
10,412,771 | Does lysophosphatidylcholine induce platelet-derived growth factor gene expression in a human mesangial cell line? | Oxidized low-density lipoprotein (oxLDL) has been considered important in the pathogenesis of progressive renal injury. Lysophosphatidylcholine (lysoPC) is a major phospholipid component of oxLDL. On the other hand, platelet-derived growth factor (PDGF) has also been implicated in proliferative disease of the kidney. T... | LysoPC may induce DNA synthesis in a mesangial cell through the induction of PDGF BB as an autocrine and paracrine growth factor. |
15,747,030 | Preoperative portal vein embolization: is it useful? | Portal vein embolization (PVE) before hepatectomy is aimed to induce an atrophy of the embolized lobe to be resected, with a compensatory hypertrophy of the counterlobe to be preserved. To answer the question "Is it useful?," we reviewed the clinical outcome in 161 patients undergoing major hepatectomy after PVE for va... | PVE is useful for performing extensive hepatectomy in patients with mild hepatic dysfunction, in those with bilobar tumors, or in those undergoing hepatopancreato duodenectomy. |
8,311,926 | Are amniotic fluid interleukin-6 determinations of diagnostic and prognostic value in preterm labor? | The purpose of this study was to determine if amniotic fluid concentrations of the interleukin-6 (IL-6) are of value in diagnosis of microbial invasion of the amniotic cavity and in the prediction of failure of tocolysis, preterm delivery and perinatal morbidity and mortality. Amniotic fluid was obtained by transabdomi... | IL-6 is a sensitive and rapid test for the detection of microbial invasion of the amniotic cavity and for identifying women at risk for spontaneous preterm delivery and neonates at risk for morbidity and mortality. |
15,845,890 | Does cannabidiol prevent cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism? | Cannabidiol has been reported to be a neuroprotectant, but the neuroprotective mechanism of cannabidiol remains unclear. We studied the neuroprotective mechanism of cannabidiol in 4-hour middle cerebral artery (MCA) occlusion mice. Male MCA occluded mice were treated with cannabidiol, abnormal cannabidiol, anandamide, ... | Cannabidiol and abnormal cannabidiol reduced the infarct volume. Furthermore, the neuroprotective effect of cannabidiol was inhibited by WAY100135 but not capsazepine, and the CBF increased by cannabidiol was partially reversed by WAY100135. These results suggested that the neuroprotective effect of cannabidiol may be ... |
11,107,130 | Does betulinic acid induce apoptosis through a direct effect on mitochondria in neuroectodermal tumors? | We identified BetA as a new cytotoxic agent active against neuroectodermal tumor cells including neuroblastoma, medulloblastoma, glioblastoma and Ewing sarcoma cells, representing the most common solid tumors of childhood. BetA induced apoptosis by a direct effect on mitochondria independent of accumulation of wild-typ... | Thus, BetA may be a promising new agent in the treatment of neuroectodermal tumors including neuroblastoma in vivo. |
23,897,106 | Is albumin concentration determined by the modified bromocresol purple method superior to that by the bromocresol green method for assessing nutritional status in malnourished patients with inflammation? | The controlling nutritional status (CONUT) score (CS), a simple score for assessing nutritional status, is calculated using laboratory data, including serum albumin concentration. Although dye-binding assays such as the bromocresol green (BCG) and modified bromocresol purple (mBCP) methods are widely used for albumin m... | The choice of albumin assay affected the assessment of nutritional status using CSs in patients with inflammation. We recommend that the modified BCP assay be used to assess nutritional status, particularly in patients with inflammation. |
18,201,705 | Are lp-PLA2 activity and mass associated with increased incidence of ischemic stroke : a population-based cohort study from Malmö , Sweden? | Data regarding the association between lipoprotein-associated phospholipase A2 (Lp-PLA(2)) level and incidence of cardiovascular (CV) events are conflicting. This prospective urban population-based study explored the relationship between baseline Lp-PLA(2) activity and mass, respectively, levels and incidence of first ... | Elevated levels of Lp-PLA(2) activity and mass, respectively, were in this study, independently of established risk factors related to the incidence of ischemic stroke but after adjustment for lipids not significant related to incident CHD. |
27,863,990 | Are cytochrome P450 enzymes but not NADPH oxidases the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays? | Measuring NADPH oxidase (Nox)-derived reactive oxygen species (ROS) in living tissues and cells is a constant challenge. All probes available display limitations regarding sensitivity, specificity or demand highly specialized detection techniques. In search for a presumably easy, versatile, sensitive and specific techn... | the cytochrome P450 system accounts for the majority of the signal of Nox activity chemiluminescence based assays. |
24,220,118 | Does alpha-linolenic acid intake prevent endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms? | Endothelial dysfunction is an important factor in the pathogenesis of diabetes related vascular complications, and acute alpha-linolenic acid (ALA) intake can increase flow-mediated dilation of the diabetic artery at 4 h postprandially. However, whether chronic ALA supplementation may prevent endothelial dysfunction in... | We concluded that ALA prevents diabetes-induced endothelial dysfunction by enhancing eNOS activity and attenuates oxidative/nitrative stress by inhibiting iNOS and NADPH oxidase expression and ONOO- production. |
20,347,079 | Is crinone vaginal gel equally effective and better tolerated than intramuscular progesterone for luteal phase support in in vitro fertilization-embryo transfer cycles : a prospective randomized study? | To compare the efficacy of Crinone vaginal gel and intramuscular progesterone (IMP) for luteal phase support in in vitro fertilization-embryo transfer (IVF-ET) with respect to pregnancy rates and outcomes, and to assess patient satisfaction with both products. Prospective randomized trial. University-affiliated IVF uni... | Crinone vaginal gel and IMP are equally effective for luteal phase support in IVF, but Crinone is better tolerated by patients. |
17,070,480 | Do lower oxygen saturation alarm limits decrease the severity of retinopathy of prematurity? | To determine whether lowering oxygen saturation alarm limits for infants at risk for retinopathy of prematurity (ROP) reduces its incidence and/or severity. Oximetry alarm limits were lowered to 85% and 93% for all infants with a birth weight 1250 g or less and/or gestational age 28 weeks or less, and maintained until ... | A simple change in oximeter alarm parameters in the first weeks of life for infants with a birth weight 1250 g or less may decrease the incidence of prethreshold ROP. |
23,859,255 | Is sexual functioning impaired in adults with congenital heart disease? | To investigate the overall sexual functioning and disease specific sexual problems in congenital heart disease (ConHD) patients, for both genders and different cardiac diagnostic groups, and compare these with Dutch normative data. Also disease specific sexual problems were investigated. From a longitudinal cohort of p... | This study shows that sexual functioning is impaired in adults with ConHD. Providing information to patients about sexuality, pregnancy, delivery and heredity should be improved, and given at young age. |
9,929,749 | Does emergency department thrombolysis critical pathway reduce door-to-drug times in acute myocardial infarction? | Rapid time to treatment with thrombolytic therapy is an important determinant of survival in acute myocardial infarction (AMI). We hypothesized that establishment of an AMI thrombolysis critical pathway in the Emergency Department could successfully reduce the "door-to-drug" time, the time between patient arrival and s... | Our critical pathway was successful in reducing door-to-drug times. We observed a "gender gap" in door-to-drug times, with longer mean times for women, which was reduced by the AMI critical pathway. Thus, our data provide support for the use of critical pathways to reduce door-to-drug times, as recommended by the Natio... |
21,055,728 | Does cyclic adenosine monophosphate-independent tyrosine phosphorylation of NR2B mediate cocaine-induced extracellular signal-regulated kinase activation? | Activation of the extracellular signal-regulated kinase (ERK) in the striatum is crucial for long-term behavioral alterations induced by drugs of abuse. In response to cocaine, ERK phosphorylation (i.e., activation) is restricted to medium-sized spiny neurons expressing dopamine D1 receptor (D1R) and depends on a conco... | Our results show that potentiation of NR2B-containing NMDAR by D1R is necessary and sufficient to trigger cocaine-induced ERK activation. They highlight a new cyclic adenosine monophosphate-independent pathway responsible for the integration of dopamine and glutamate signals by the ERK cascade in the striatum and for l... |
21,119,545 | Do treatment-by-histology interaction analyses in three phase III trials show superiority of pemetrexed in nonsquamous non-small cell lung cancer? | Recently, histology has emerged as a predictive factor for pemetrexed efficacy in non-small cell lung cancer (NSCLC). These analyses evaluate whether the differential efficacy of pemetrexed by NSCLC histology is reproducible and consistent across three registration studies of different lines of therapy (first-line/seco... | These analyses demonstrate a statistically significant interaction between treatment effect and NSCLC histology, indicating superior efficacy of pemetrexed in nonsquamous patients compared with other standard treatment options. Thus, histology is consistently predictive of the improved efficacy of pemetrexed in patient... |
9,858,292 | Can the C-14 urea breath test replace follow-up endoscopic biopsies in patients treated for Helicobacter pylori infection? | The C-14 urea breath test (UBT) is the most specific noninvasive test to detect Helicobacter pylori, with reported sensitivity and specificity rates of 90% and 95%, respectively. This test has not been evaluated for eradication after a therapeutic trial. The goal of this study was to assess the accuracy of C-14 UBT in ... | The C-14 UBT was an accurate, rapid, and easily administered test to diagnose initial H. pylori infection and to monitor its eradication, thereby obviating the need for repeated endoscopic biopsies. |
20,538,300 | Does dietary restriction modify certain aspects of the postoperative acute phase response? | Lifespan extension is achieved through long-term application of dietary restriction (DR), and benefits of short-term dietary restriction on acute stress and inflammation have been observed. So far, the effects of short-term DR in humans are relatively unknown. We hypothesized that short-term DR in humans reduces the ac... | A relatively short preoperative dietary restriction regimen was able to modify certain aspects of the postoperative acute phase response. These data warrant further studies into the dietary conditions that improve stress resistance in humans. (Dutch Trial Registry number: NTR1875). |
17,976,039 | Are secondary sexual coloration and CSF 5-HIAA correlated in vervet monkeys ( Cercopithecus aethiops sabaeus )? | Identifying indirect markers of the physiology or neuroendocrinology of a primate can provide a powerful tool to scientists. Anecdotal descriptions and recent experimental evidence suggests that the colorful sexual skin in adult male vervet monkeys (Cercopithecus aethiops sabaeus) might be sensitive to social changes, ... | These preliminary data are compatible with the hypothesis that scrotal coloration serves as an indirect marker of serotonergic activity. These findings suggest that color assessments might be useful to consider for study design, as well as for animal welfare and captive management. |
25,945,525 | Do results of pars plana vitrectomy after complicated phacoemulsification surgery? | To identify the causes and outcomes of pars plana vitrectomy (PPV) in patients undergoing phacoemulsification with intraoperative complication and to analyze whether the interval between phacoemulsification and PPV interferes with best-corrected final visual acuity. This descriptive and retrospective analytical study w... | This study is in agreement with worldwide literature, asserting that major complications of phacoemulsification are posterior capsule rupture and capsular bag detachment, and in addition, there is an improvement in the final visual acuity in almost half the cases, even when there are complications during modern catarac... |
26,680,311 | Does survival in Patients With Esophageal Adenocarcinoma Undergoing Trimodality Therapy be Independent of Regional Lymph Node Location? | The American Joint Committee on Cancer Cancer Staging Manual 7th Edition esophageal cancer staging was derived from outcomes of patients undergoing esophagectomy alone and eliminated nodal location from its schema. A limitation of this staging system is that it has not been validated in the setting of multimodality the... | The location of cN+ regional node disease in patients with distal esophageal or GEJ adenocarcinoma was not predictive of survival after trimodality therapy. Age, sex, pathologic tumor depth, and the number of involved nodes were independent predictors of survival. Patients with cN+ cancers should not be deprived of pot... |
26,549,913 | Can Visual Field Progression be Predicted by Confocal Scanning Laser Ophthalmoscopic Imaging of the Optic Nerve Head in Glaucoma? | To determine whether confocal scanning laser ophthalmoscopic imaging (Heidelberg retinal tomography [HRT]) can predict visual field change in glaucoma. The study included 561 patients with glaucoma or ocular hypertension whose clinical course was followed at the Mount Sinai Faculty practice. Humphrey visual fields (HVF... | Trend-based analysis of HRT parameters has poor sensitivity and specificity in predicting HVF change. This may be related specifically to HRT imaging or may reflect the fact that in some patients with glaucoma, functional changes precede structural alterations. |
27,239,425 | Are skeletal muscle satellite cells located at a closer proximity to capillaries in healthy young compared with older men? | Skeletal muscle satellite cells (SC) are instrumental in maintenance of muscle fibres, the adaptive responses to exercise, and there is an age-related decline in SC. A spatial relationship exists between SC and muscle fibre capillaries. In the present study, we aimed to investigate whether chronologic age has an impact... | We demonstrate that there is a greater distance between capillaries and type II fibre-associated SC in OM as compared with YM. Furthermore, quiescent SC are located significantly further away from capillaries than active SC after single bout of exercise. Our data have implications for how muscle adapts to exercise and ... |
24,694,020 | Does lactobacillus helveticus-fermented milk improve learning and memory in mice? | To investigate the effects of Calpis sour milk whey, a Lactobacillus helveticus-fermented milk product, on learning and memory. We evaluated improvement in scopolamine-induced memory impairment using the spontaneous alternation behaviour test, a measure of short-term memory. We also evaluated learning and working memor... | These results suggest that Calpis sour milk whey may be useful for the prevention of neurodegenerative disorders, such as Alzheimer's disease, and enhancing learning and memory in healthy human subjects; however, human clinical studies are necessary. |
21,450,334 | Does curcumin disrupt uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition? | Uterine leiomyosarcoma generally has an unfavorable response to standard chemotherapy. The loss of PTEN which results in constitutive AKT-mTOR activation causes an increase in leiomyosarcoma formation in mice. The active ingredient derived from the herb Curcuma longa, curcumin, shows antitumor properties in a variety o... | Curcumin inhibited uterine leiomyosarcoma cells' growth by targeting the AKT-mTOR pathway for inhibition. However, rapamycin, a specific mTOR inhibitor, did not induce apoptosis in SKN cells unlike curcumin that also has a pro-apoptotic potential in SKN cells. |
17,668,049 | Does obstetrician-assessed maternal health at pregnancy predict offspring future health? | We aimed to examine the association between obstetrician assessment of maternal physical health at the time of pregnancy and offspring cardiovascular disease risk. We examined this association in a birth cohort of 11,106 individuals, with 245,000 person years of follow-up. We were concerned that any associations might ... | These findings demonstrate that a simple assessment of physical health (based on the appearance of eyes, skin, hair and teeth) of mothers at the time of pregnancy is a strong indicator of the future health risk of their offspring for common conditions that are associated with poor socioeconomic position and unhealthy b... |
22,610,850 | Does novel small molecule α9α10 nicotinic receptor antagonist prevent and reverses chemotherapy-evoked neuropathic pain in rats? | Peripheral neuropathy is a common dose-limiting side effect of chemotherapy. There are no clinically proven analgesics for the treatment of this condition. Drugs from different classes have been tested with mixed results. Identification of novel molecular targets for analgesic(s) is important. Antagonism of the α9α10 n... | This study suggests that ZZ1-61c, a novel compound with a unique mechanism of antagonistic action at the α9α10 nAChR, may be a potential drug candidate for prevention and attenuation of neuropathic pain resulting from chemotherapy. Such a strategy may provide effective treatment that circumvents toxicity of centrally a... |
17,302,699 | Does heart rate turbulence after atrial premature complexes depend on coupling interval and atrioventricular nodal conduction? | Positive Turbulence onset (TO) after atrial premature complexes (APCs) was found temporally related to spontaneous episodes of atrial fibrillation. This study tested the hypothesis that heart rate turbulence (HRT) after APCs is influenced by APC prematurity independently of the prematurity of conducted ventricular comp... | The early phase of HRT is strongly influenced by the coupling interval of APCs, independently of the prematurity of conducted ventricular complexes. Consequently, the more positive TO preceding spontaneous atrial fibrillation episodes might be an epiphenomenon of incidental short-coupled APCs with delayed AV conduction... |
11,379,350 | Does hepatocyte growth factor promote liver regeneration and protein synthesis after hepatectomy in cirrhotic rats? | Hepatocyte growth factor, a potent mitogen for hepatocytes has been reported to be a hepatrophic factor in normal livers. In this study, the effect of exogenous hepatocyte growth factor on liver regeneration in cirrhotic rats was investigated, in vitro and in vivo. Liver cirrhosis was induced by intraperitoneal injecti... | These results indicate that exogenous hepatocyte growth factor may promote DNA synthesis and protein synthesis during liver regeneration after Hx with cirrhosis. |
17,272,775 | Does quantified corticospinal tract diffusion restriction predict neonatal stroke outcome? | Neonatal arterial ischemic stroke occurs in > or =1:4000 births. Many children experience motor deficits but acute predictors of outcome are lacking. Diffusion-weighted MRI changes in descending corticospinal tracts remote from arterial ischemic stroke may represent pre-Wallerian degeneration. We verify and quantify th... | Descending corticospinal tracts diffusion-weighted MRI signal is predictive of motor outcome from neonatal arterial ischemic stroke. This accurate, reliable, and simple tool will impact decision making in acute neonatal stroke. |
12,962,288 | Do cell-cycle alterations underlie cyclophosphamide-induced teratogenesis in the chick embryo? | Cyclophosphamide (CP) embryotoxicity was documented in several studies on different experimental models. We investigate quantitatively the relationship between the embryotoxic effect of CP and the disturbance of the cell-cycle using flow cytometry. Chick embryos on Days 2-4 were treated with 0.5, 1, 2, 4, 8, and 16 mic... | CP-induced cytotoxicity manifested by dose-dependent disturbance of cell-cycle resulted in an overall depression of proliferation activity clearly associated with the occurrence of malformations and embryonic death. Although a non-significant depression of mitotic activity appeared sufficient to produce malformations o... |
20,385,918 | Is it ADEM, POLG, or both? | To describe a child with apparent brain biopsy-confirmed acute disseminated encephalomyelitis (ADEM) but genetic confirmation of compound heterozygosity for DNA mutations of the polymerase gamma (POLG) gene. Case report. Tertiary referral center. A 4-year-old boy presented with ataxia and encephalopathy. Magnetic reson... | This case raises interesting questions about whether ADEM triggered severe neurologic degeneration in a patient with mitochondrial disease, whether mitochondrial disease predisposed to a pathologic immune response, or whether mitochondrial disease can mimic an autoimmune disease. Mitochondrial disease-causing mutations... |
16,448,388 | Are rho/ROCK-dependent pseudopodial protrusion and cellular blebbing regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation? | The c-Met-dependent, beta-actin-rich, blebbed pseudopodia of MSV-MDCK-INV (invasive Moloney-sarcoma-virus-transformed Madin-Darby canine kidney) cells are induced by Rho/ROCK (Rho kinase) activation, and are morphologically distinct from flat extended lamellipodia. Microtubules were shown to extend to these actin-rich ... | The localized activation of an autocrine HGF/c-Met loop regulates Rho/ROCK activation of p38 MAPK signalling to stimulate both membrane blebbing and pseudopod formation. |
27,613,891 | Does chronic Nicotine Treatment During Adolescence attenuate the Effects of Acute Nicotine in Adult Contextual Fear Learning? | Adolescent onset of nicotine abuse is correlated with worse chances at successful abstinence in adulthood. One reason for this may be due to enduring learning deficits resulting from nicotine use during adolescence. Previous work has indicated that chronic nicotine administration beginning in late adolescence (PND38) c... | These results suggest that adolescent nicotine exposure impairs learning in adulthood, which could increase the risk for continued nicotine use in adulthood by requiring administration of higher doses of nicotine to reverse learning impairments caused by adolescent nicotine exposure. |
21,868,705 | Does calcification in major vessel beds relate to vascular brain disease? | Calcification in atherosclerotic plaques is a novel marker of atherosclerosis and is related to cardiovascular disease. However, its relationship with cerebrovascular disease has not been investigated extensively. We investigated the relationship between calcification in various vessel beds outside the brain and imagin... | Arterial calcification in major vessel beds is associated with vascular brain disease on magnetic resonance imaging. Most notably, larger intracranial carotid calcification load relates to larger WML volumes, and larger extracranial carotid calcification load relates to the presence of cerebral infarcts, independently ... |
15,869,764 | Is angiotensin converting enzyme-independent angiotensin ii production by chymase up-regulated in the ischemic kidney in renovascular hypertension? | Tissue angiotensin II (ANG II) levels are elevated in both kidneys in renovascular hypertension (RVH). It has been demonstrated previously that intrarenal ANG II is augmented by an angiotensin converting enzyme (ACE) dependent mechanism in the non-ischemic kidney, but the role of ACE-independent production of ANG II in... | Chymase activity is up-regulated in the ischemic kidney of 2K1C rats. Plasma ANG II does not appear to regulate intrarenal chymase activity, suggesting that ischemia per se up-regulates chymase activity in the kidney. ACE-independent ANG II production by chymase may provide a mechanism for augmenting intrarenal ANG II ... |
24,400,704 | Do steroid users and the unique challenge they pose to needle and syringe program workers? | Needle and syringe programs (NSP), which provide sterile injecting equipment, are a cornerstone of Australia's drug harm reduction strategy and assist in reducing the spread of blood-borne virus infections, such as HIV and hepatitis C, among people who inject drugs. Some reports suggest that steroid users are an increa... | PIED users pose unique challenges for NSP workers compared with other NSP client groups. The PIEDs used and the way in which they are used are substantially different compared with other NSP clients, and there appears to be a lack of knowledge within the workforce about these substances. This study highlights the need ... |
19,587,781 | Does a novel tandem reporter quantify RNA polymerase II termination in mammalian cells? | Making the correct choice between transcription elongation and transcription termination is essential to the function of RNA polymerase II, and fundamental to gene expression. This choice can be influenced by factors modifying the transcription complex, factors modifying chromatin, or signals mediated by the template o... | The tandem construct provides a sensitive measure of transcription termination in human cells. Decreased Xrn2 or Senataxin levels produced only a modest release from termination. Our data support overlap in allosteric and torpedo mechanisms of transcription termination and suggest that efficient termination is ensured ... |
10,976,813 | Does painting Qa-2 onto Ped slow preimplantation embryos increase the rate of cleavage? | Qa-2 protein, the Ped gene product, is linked to the cell surface by a glycosylphosphatidylinositol (GPI) anchor. Some GPI-linked proteins can be spontaneously incorporated into the membranes of cells via a technique called "protein painting."We investigated whether Qa-2 could be painted onto T cells and embryos and wh... | GPI-linked Qa-2 protein "painted" onto both T cells and preimplantation embryos is functional, as shown by increased proliferation of T cells after cross-linking with anti-Qa-2 antibody, and increased rate of cleavage division of the embryos. |
11,014,540 | Do telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker? | Telomerase activity is responsible for cell immortality. To examine the role of telomerase in the carcinogenesis of human glioblastomas multiforme (GBMs), the authors studied telomerase activity, telomerase component expression, and telomere lengths in 42 GBM samples. In all samples, EGFR and MDM2 amplifications and ov... | These results suggest that telomerase activity and p53 mutations both play important roles in the multistep carcinogenesis of GBMs. Telomerase activity and hTERT expression may be considered as novel distinctive factors in human GBMs. |
16,955,614 | Do a new device in immediately loaded implant treatment in the edentulous mandible? | This article reports preliminary clinical results of the Speed Master system, a method for immediate loading of implants for the treatment of mandibular edentulism. Fifteen patients with edentulous mandibles were consecutively included in the study. Each received 4 implants between the mental foramina placed using the ... | The immediate loading of implants placed in the edentulous mandible with the Speed Master surgical and prosthetic protocol reduces treatment time and number of surgical procedures in comparison to classic delayed loading protocols. |
25,935,870 | Does thromboxane A2 induce blood flow recovery via platelet adhesion to ischaemic regions? | Thromboxane A2 (TXA2) induces platelet adhesion through thromboxane prostanoid (TP) receptor. Platelets contain many pro-angiogenic factors and are recruited to the site of vascular injury. However, the cellular and molecular mechanisms of platelet-dependent angiogenesis, especially the involvement of TP signalling, ha... | These results indicated that TP signalling facilitates ischaemia-induced angiogenesis via P-selectin-mediated platelet adhesion to PSGL-1 on the ECs at ischaemic sites and the supply of pro-angiogenic factors by the adherent platelets. |
27,809,878 | Is synuclein-γ ( SNCG ) expression in ovarian cancer associated with high-risk clinicopathologic disease? | Synuclein gamma (SNCG) expression is associated with advanced disease and chemoresistance in multiple solid tumors. Our goal was to determine if SNCG protein expression in ovarian cancer was correlated with clinicopathologic variables and patient outcomes. Tissue microarrays from primary tumors of 357 ovarian, fallopia... | SNCG expression in ovarian cancer is frequent in patients with high-risk features, but it does not correlate with chemotherapy response, overall survival, or progression-free survival. |
24,156,734 | Does procalcitonin biomarker kinetics fail to predict treatment response in perioperative abdominal infection with septic shock? | Procalcitonin (PCT) biomarker is suggested to tailor antibiotic therapy in the medical intensive care unit (ICU) but studies in perioperative medicine are scarce. The aim of this study was to determine whether PCT reported thresholds are associated with the initial treatment response in perioperative septic shock secon... | In perioperative intra-abdominal infections with shock, PCT decrease to 0.5 ng/ml lacked sensitivity to predict treatment response and its decrease of at least 80% from its peak failed to accurately predict treatment response. Studies in perioperative severe infections are needed before using PCT to tailor antibiotic u... |
22,691,411 | Is a novel role for APOBEC3 : susceptibility to sexual transmission of murine acquired immunodeficiency virus ( mAIDS ) aggravated in APOBEC3 deficient mice? | APOBEC3 proteins are host factors that restrict infection by retroviruses like HIV, MMTV, and MLV and are variably expressed in hematopoietic and non-hematopoietic cells, such as macrophages, lymphocytes, dendritic, and epithelia cells. Previously, we showed that APOBEC3 expressed in mammary epithelia cells function to... | Our data indicate that genital tissue intrinsic APOBEC3 restricts genital tract infection and limits sexual transmission of LP-BM5 virus. |
25,713,589 | Does low dose aminophylline effectively decrease the risk of post-operative apnea in premature infants? | Retinopathy of prematurity (ROP) is the most common reason behind surgical procedures in premature newborns. Anesthesia in these patients is life-threatening due to post-operative apnea of prematurity (POA). This study aimed to determine the predisposing factors to POA in premature infants and to explore the role of pr... | Aminophylline can be used prophylactically to decrease the risk of postoperative apnea with no major adverse effects. |
10,951,352 | Is use of complementary and alternative medicine by cancer patients associated with perceived distress or poor compliance with standard treatment but with active coping behavior : a survey? | Complementary and alternative medicine (CAM) is often used by cancer patients. Data on characteristics of users, concomitant psychologic disturbance, and compliance with standard treatment continue to be controversial. Use of and interest in CAM and their correlation with psychologic disturbance, ways of coping with il... | Use of CAM by cancer patients is not associated with perceived distress or poor compliance with medical treatment but with active coping behavior. Patients seem to consider CAM as supplementary to standard medical methods and one way of avoiding passivity and of coping with feelings of hopelessness. |
8,933,762 | Does lens-specific expression of PDGF-A in transgenic mice result in retinal astrocytic hamartomas? | To investigate the possibility that platelet-derived growth factor (PDGF) might regulate aspects of mouse retinal development in vivo. In situ hybridization was used to study the expression patterns of PDGF-A and PDGF-B and their receptors during normal mouse eye development. Transgenic mice that express human PDGF-A i... | These findings suggest that proliferation of retinal astrocytes is regulated by PDGF during normal eye development. The authors speculate that proliferation of retinal astrocytes is mediated through a PDGF signaling pathway, which may involve the TSC gene product. |
22,605,914 | Does retinol dehydrogenase 13 protect the mouse retina from acute light damage? | To investigate whether retinol dehydrogenase 13 (RDH13) can protect the retina from acute light-induced damage. We generated Rdh13 knockout mice using molecular biologic methods and assessed the associated morphological and functional changes under room-light conditions by hematoxylin-eosin (H&E), transmission electron... | Rdh13 can protect the retina against acute light-induced retinopathy. The mechanism may involve inhibition of the mitochondrial apoptosis pathway. |
18,337,634 | Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease? | Components of the metabolic syndrome are highly prevalent in chronic kidney disease (CKD) patients--some of which paradoxically appear to predict an improved outcome in this population. We hypothesized that the circulating calcification inhibitor fetuin-A/AHSG, which is also a natural inhibitor of the tyrosine kinase i... | The present, explorational, study supports further, mechanistic, studies into a physiological link between AHSG and body fat mass in patients with CKD. As we observed an association between higher fat mass and elevated AHSG levels, these preliminary results may form the basis of further study to establish if the observ... |
27,209,066 | Is chronic Cystoisospora belli infection in an immunocompetent Myanmar refugee - microscopy sensitive enough? | Cystoisosporiasis is an opportunistic infection seen more commonly in patients with acquired immunodeficiency syndrome. Although uncommon, Cystoisospora infection can occur in immunocompetent individuals but tend to be benign and self-limiting. Chronic infection however, has been described but diagnosis can often be ch... | In the appropriate clinical context we suggest molecular testing for C. belli or an empirical therapeutic trial. |
23,643,818 | Are common two-dimensional echocardiographic estimates of aortic linear dimensions interchangeable? | To compare two echocardiographic methods of measuring aortic diameter in short-axis projections. Right-parasternal short-axis 2-dimensional projections of the left atrium and aorta were obtained from dogs and cats undergoing routine cardiac evaluation. Two investigators measured the aortic valve linear dimension using ... | Our results show sufficient agreement between two common methods used to measure aortic linear dimensions to suggest that these methods are interchangeable. |
23,225,418 | Does overexpression of CD9 in human breast cancer cells promote the development of bone metastases? | Bone is a preferred target for circulating metastatic breast cancer cells. We found that the CD9 protein was up-regulated in the B02 osteotropic cell line, derived from the aggressive parental MDA-MB-231 breast cancer cell line. Here, we investigated the putative relationship between CD9 expression and the osteotropic ... | Our study reveals a potential implication of CD9 in the formation of bony metastases from breast cancer cells. |
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