section stringclasses 51
values | label stringclasses 9
values | Courses of Treatment stringlengths 6 98.9k ⌀ | Important Radiologic stringlengths 40 1.05k ⌀ | Patient History stringlengths 1 479 ⌀ |
|---|---|---|---|---|
Case 32 | HR(−) HER2(−) Breast Cancer | 32.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and . cyclophosphamide + #4 cycles. of docetaxel) + Operation + Post-operative. radiation therapy + Adjuvant capecitabine.. . . . HR(−) HER2(−) Breast Cancer. 694. . . Operation. 242. Pathology Report. Invasive Ductal Carcinoma. 1... | Important Radiologic. Findings. 234 235 236. 237. . HR(−) HER2(−) Breast Cancer. 692. . . . . . E. S. Lee et al.. 693. . After Neoadjuvant. Chemotherapy. 238 239 240. 241. 32.3. | Patient History and Progress. Female/49 years old, pre-menopause.. Self-detected mass lesion on left breast.. Family history of breast cancer, aunt and. cousin (paternal).. Family history of prostate cancer, father.. Hyperthyroidism.. BRCA 1 and 2 mutation: Not detected.. 32.2. |
Case 32 | Local Recurrence | 32.1. . Courses of Treatment. Right breast DCIS → Operation → Adjuvant. therapy → Right breast recurrence (tubular. carcinoma + DCIS).. Primary Treatment. Operation. Aug. 2014 Right breast wide excision (outside).. Pathology Report. Ductal carcinoma in situ involving intraductal. papilloma. . 1. Nuclear grade: low.. ... | null | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected mass lesion on right breast. . 12 o’clock direction.. Outside result of lumpectomy: Ductal carci. noma in situ.. No family history.. No comorbidities.. BRCA 2 VUS (variant of uncertain).. 32.2. |
Case 32 | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. receptor. Intermediate. (4/7). 2. 10%–1/3. Progesterone. receptor. Strong (6/7). 3. 1/3–2/3–. C-erbB2. Positive (3+). Ki-67. Positive in. 20% of tumor. cells. Y. Kwon et al.. & Doxorubicin & Cyclophosphamide)... | null | Patient History and Progress. Female/49 years old, peri-menopause.. No family history.. 32.2. |
Case 33 | Carcinoma In Situ | 33.1. . Courses of Treatment:. Operation. Operation. 155. 156. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary/cribriform.. . 5. ... | Important Radiologic. Findings. 153. 154. 33.3. | Patient History and Progress. Female/68 years old, post-menopause.. Bloody nipple discharge from right breast.. No family history.. S/P Hysterectomy.. 33.2. |
Case 33 | HR(+) HER2(+) Breast Cancer | Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 194. Pathology Report. Invasive ductal carcinoma, histologic grade 2.. No residual tumor with stromal ... | Important Radiologic. Findings. 190 191 192. 193. 33.3. | Self-detected palpable mass lesion on left. breast.. No family history.. No comorbidities.. 33.2. |
Case 33 | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. Y. Kim et al.. micropapillary/cribriform, extensive intra. ductal component: present).. 5. Skin: no involvement of tumor.. HR(+) HER2(−) Breast Cancer. . (e) deep margin: 3 mm.. . (f) superficial margin: 5 mm.. Y. Kim et... | Important Radiologic. Findings. See Figs. 180, 181, 182, 183 and 184.. 33.3. | Restless legs.. 33.2. |
Case 33 | HR(−) HER2(+) Breast Cancer | 33.1. . tion therapy + Trastuzumab.. Operation. 228. Pathology Report. . 1. No residual tumor with foamy histiocytic. collection.. . (a) Post-chemotherapy status.. . (b) Lymph nodes: no metastasis in four axil. lary lymph nodes (ypN0(sn)) (sentinel. LN: 0/4).. . (c) Microcalcification:. present,. tumoral/. non-tu... | Important Radiologic. Findings. 221 222 223. 224. HR(−) HER2(+) Breast Cancer. . HR(−) HER2(+) Breast Cancer. 552. . 33.3. . After Neoadjuvant. Chemotherapy. 225 226. 227. Y. Kwon et al. | Patient History and Progress. Female/63 years old, post-menopause.. Self-detected palpable mass lesion on left. breast 2 o’clock direction.. No family history.. Hypertension, chronic kidney disease, ven. tricular premature contraction.. 33.2. |
Case 33 | HR(−) HER2(−) Breast Cancer | 33.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy.. Operation. 251. Pathology Report. Atypical ductal hyperplasia, focal. . 1. Post-chemotherapy status.. . 2. Lymph nodes: no metast... | Important Radiologic. Findings. 243 244 245. 246. . . HR(−) HER2(−) Breast Cancer. 696. . . . . After Neoadjuvant. Chemotherapy. 247 248 249. 250. 33.3. | Patient History and Progress. Female/52 years old, post-menopause.. Screen detected mass lesion on left breast 11. o’clock direction.. No family history.. s/p cervical cancer (stage 0).. BRCA 1 and 2 mutation: Not detected.. 33.2. |
Case 33 | Local Recurrence | 33.1. . Courses of Treatmaent. Left breast IDC → Neoadjuvant chemotherapy. → Operation → Adjuvant therapy → Left breast. recurrence (IDC).. Primary Treatment. 225 226 227. 228. Neoadjuvant Chemotherapy. Neoadjuvant chemotherapy #6 cycles of trastu. zumab and pertuzumab and docetaxel and. carboplatin.. Operation. . 2... | null | Patient History and Progress. Female/45 years old, pre-menopause.. Screen detected mass lesion on upper inner. portion of left breast.. Outside result of biopsy: Invasive ductal. carcinoma.. Family history of breast cancer, mother at her. 50 years old.. S/P. Hysterectomy,. s/p. bilateral. breast. augmentation.. 33.2. |
Case 33 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Bone metastasis.. Primary Treatment. Estrogen. receptor. Strong (8/8). 3. >2/3. Progesterone. receptor. Intermediate. (5/8). 2. 10%–. 1/3. Result. Intensity. Positive %. C-erbB2. Equivocal (2+). Ki-67. Positive in 7%. of tumor cells. SISH. Posi... | null | |
Case 34 | Carcinoma In Situ | 34.1. . Courses of Treatment:. Operation. Operation. 161. 162. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary/cribriform.. . 5. ... | Important Radiologic. Findings. 157 158 159. 160. 34.3. | Patient History and Progress. Female/53 years old, pre-menopause.. Screen detected mass lesion on upper outer of. right breast.. No family history.. S/P Total gastrectomy (gastric cancer), micro. papillary thyroid carcinoma (follow-up).. BRCA 1 and 2: Not examination.. 34.2. |
Case 34 | HR(+) HER2(+) Breast Cancer | 34.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab. and Pertuzumab + Letrozole 2.5 mg/day.. 201. Pathology Report. Invasive ductal carcinoma, histologic grade 2.. No resid... | Important Radiologic. Findings. 195 196 197 198 199. 200. 34.3. | Patient History and Progress. Female/55 years old, post-menopause.. Self-detected palpable mass lesion on right. breast 9 o’clock direction.. No family history.. No comorbidities.. 34.2. |
Case 34 | HR(+) HER2(-) Breast Cancer | 34.1. . Courses of Treatment. Operation. Right nipple–areolar complex sparing mastec. tomy with immediate implant reconstruction,. sentinel lymph node biopsy, left nipple–areo. lar complex sparing mastectomy with immedi. ate implant reconstruction (Figs. 190, 191 and. 192).. Pathology Report. [Right]. Invasive Duct... | Important Radiologic. Findings. See Figs. 186, 187, 188 and 189.. 34.3. | Patient History and Progress. Female/43 years old, pre-menopause.. Screen for high risk for breast cancer.. Family history of breast cancer, mother.. Pancreatic cancer, maternal uncle.. No comorbidities.. BRCA 1 mutation carrier.. 34.2. |
Case 34 | HR(−) HER2(+) Breast Cancer | 34.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4 cycles. of. doxorubicin. +. cyclophosphamide). +. Operation + Trastuzumab.. Operation. 233. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c(Paget)).. 2. Histologic grade: 3/3 (tubule formation: 3/3,. nuclear pleomorphism:... | Important Radiologic. Findings. 229 230 231. 232. . HR(−) HER2(+) Breast Cancer. 556. . . . . 34.3. | Patient History and Progress. Female/54 years old, post-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. S/P. unilateral. salpingo-oophorectomy,. dyslipidemia.. HR(−) HER2(+) Breast Cancer. 554. a. b. . Y. Kwon et al.. 555. 34.2. |
Case 34 | HR(−) HER2(−) Breast Cancer | 34.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#1. cycles of docetaxel and cyclophosphamide,. stop d/t mucositis).. Operation. 255. Pathology Report. Invasive Ductal Carcinoma associated with. paraffinoma. 1. Size of tumor: 3.0 cm (pT2).. . . E. S. Lee et al.. 701. 2. Histologic grade: 3/3 (tubul... | Important Radiologic. Findings. 252 253. 254. . . HR(−) HER2(−) Breast Cancer. 700. 34.3. | Patient History and Progress. Female/79 years old, post-menopause.. Screen detected mass lesion on left breast 12. o’clock direction.. No family history.. S/P paraffin injection, s/p appendectomy, s/p. hysterectomy, s/p hemicolectomy (colon cancer).. S/P radical total gastrostomy (advanced gas. tric cancer).. BRCA 1 a... |
Case 34 | Local Recurrence | 34.1. . Courses of Treatment. Right breast IDC → Operation → Adjuvant. therapy → Right breast recurrence (IDC).. Primary Treatment. 233 234. 235. Operation. 236. Pathology Report. Invasive Ductal Carcinoma. 1. Size of invasive component: 0.7 cm (pT1b).. 2. Size of intraductal component: 1.0 cm.. 3. Histologic grade... | null | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected microcalcification on upper. outer portion of right breast.. Family history of ovarian cancer mother.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 34.2. |
Case 34 | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Right pleural, liver, right adrenal. gland, bone metastasis → Brain metastasis.. Primary Treatment. (0/8). 0. 0. Progesterone. receptor. Negative. (0/8). 0. 0. C-erbB2. Equivocal. (2+). Ki-67. Positive. in 46% of. tumor. cells. SISH. Positive. A... | null | No family history.. 34.2. |
Case 35 | Carcinoma In Situ | 35.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 165. 166. Pathology Report. Lobular carcinoma in situ, pathological TN. category (AJCC 2017): pTis. . 1. Size of tumor: 0.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. ... | Important Radiologic. Findings. 163. 164. 35.3. | Patient History and Progress. Female/59 years old, post-menopause.. Screen detected ductal dilatation on left breast. 12 o’clock direction.. No family history.. S/P Hysterectomy and bilateral salpingo-. oophorectomy, S/P total thyroidectomy (thyroid. cancer), hypertension.. 35.2. |
Case 35 | HR(+) HER2(+) Breast Cancer | 35.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. S. Park et al.. 209. 210. Pathology Report. Invasive ductal carcinoma, histologic grade 3.. No residual tumor with stromal degeneration.. . 1. Post-chemotherapy status.. . 2. Lymph nodes: no metastasis in... | Important Radiologic. Findings. 202 203 204 205 206 207. 208. 35.3. | Patient History and Progress. Female/39 years old, pre-menopause.. Self-detected skin change and palpable mass. lesion on right breast 9:30 o’clock direction.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 35.2. |
Case 35 | HR(+) HER2(-) Breast Cancer | 35.1. . cribriform/solid/comedo, extensive intra. ductal component: present).. 5. Skin: no involvement of tumor.. 6. Surgical margins:. . (a) superior margin: 15 mm.. . (b) inferior margin: 15 mm.. . (c) medial margin: 10 mm.. . (d) lateral margin: 10 mm.. . (e) deep margin: 2 mm.. . (f) superficial margin: 2... | Important Radiologic. Findings. See Figs. 193, 194, 195, 196 and 197.. Y. Kim et al. | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected mass lesion on left breast 4. o’clock direction.. Family history of breast cancer, maternal aunt.. No comorbidities.. BRCA 1 and 2 mutation: no examination.. 35.2. |
Case 35 | HR(−) HER2(+) Breast Cancer | 35.1. . Courses of Treatment. Neoadjuvant chemotherapy (#5 cycles of. docetaxel. and. trastuzumab. and. pertu. zumab) + Operation + Post-operative radiation. therapy + Trastuzumab and pertuzumab.. Operation. 242. Pathology Report. Microinvasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of invasive... | Important Radiologic. Findings. 234 235 236. 237. Y. Kwon et al.. 559. . . . HR(−) HER2(+) Breast Cancer. 560. . . Y. Kwon et al.. 561. 35.3. . After Neoadjuvant. Chemotherapy. 238 239 240. 241. 35.4. | Patient History and Progress. Female/73 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. Family history of breast cancer, cousin. (maternal).. s/p cholecystectomy, s/p unilateral salpingo-. oophorectomy, hypertension, diabetes mellitus.. BRCA 1 and 2 mutation: Not detected.. 35.2. |
Case 35 | HR(−) HER2(−) Breast Cancer | 35.1. . Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of doxorubicin and cyclophospha. mide) + Post-operative radiation therapy.. Operation. 259. Pathology Report. Invasive Ductal Carcinoma with apocrine. differentiation. 1. Size of tumor: 1.1 cm (pT1c).. 2. Histologic grade: 3/3 (tubule f... | Important Radiologic Findings. 256 257. 258. 35.3. | Patient History and Progress. Female/75 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. Hypertension, Hyperlipidemia, s/p hysterec. tomy, arrhythmia (s/p operation).. 35.2. |
Case 35 | Local Recurrence | 35.1. . Courses of Treatment. Right breast IDC → Neoadjuvant chemotherapy. → Operation → Adjuvant therapy → Right. breast recurrence (DCIS).. Primary Treatment. Operation. First Operation (Aug. 2004) Left breast conserv. ing surgery, sentinel lymph node biopsy.. Pathology Report. Invasive Ductal Carcinoma. 1. Size o... | null | Patient History and Progress. Female/53 years old, peri-menopause.. Screen detected mass lesion on left breast. subareola.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 35.2. |
Case 35 | Metastatic Breast Cancer | 35.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Bone metastasis.. Primary Treatment. Strong (8/8). 3. >2/3. Progesterone. receptor. Negative (0/8). 0. 0. C-erbB2. Negative (1+). Ki-67. Positive in. 16% of tumor. cells. Oncotype Dx test: 23 (Recurrence Score).. Adjuvant Therapy. Post... | null | Patient History and Progress. Female/51 years old, pre-menopause.. No family history.. S/p. hysterectomy. &. Left. salpingo-. oophorectomy (benign), s/p total hip replacement. arthroplasty.. 35.2. |
Case 36 | Carcinoma In Situ | 36.1. . Courses of Treatment:. Operation. Operation. 169. 170. Pathology Report. Lobular carcinoma in situ. . 1. Size of tumor: 0.5 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. Skin: no involvement of tumor.. . 6. Surgical margins:. . (a) superior margin: 10 mm... | Important Radiologic. Findings. 167. 168. 36.3. | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on right breast. 11 o’clock direction.. No family history.. No comorbidities.. 36.2. |
Case 36 | HR(+) HER2(+) Breast Cancer | 36.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel and cyclophosphamide and. trastuzumab) + Post-operative radiation ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 215. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 (t... | Important Radiologic. Findings. 211 212 213. 214. 36.3. | Patient History and Progress. Female/42 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast 5:30 o’clock direction.. No family history.. S/P Right pneumonectomy (lung cancer).. BRCA 1 and 2 mutation: Not examination.. 36.2. |
Case 36 | HR(+) HER2(-) Breast Cancer | 36.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. Operation. Right breast conserving surgery, sentinel lymph. micropapillary/cribri. form, extensive intraductal component:. present).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margi... | Important Radiologic. Findings. See Figs. 199, 200, 201, 202 and 203.. 36.3. | Patient History and Progress. Female/50 years old, pre-menopause.. Screen detected mass lesion on right breast 10. o’clock direction.. No family history.. s/p endometrial curettage.. 36.2. |
Case 36 | HR(−) HER2(+) Breast Cancer | 36.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab.. 245. Pathology Report. . 1. No residual tumor with foamy histiocytic. collection.. . (a) Post-chemotherapy status.. . ... | Important Radiologic. Findings. 243. 244. 36.3. | Patient History and Progress. Female/63 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. Hypertension, chronic renal failure, ventricu. lar premature contraction.. S/P cholecystectomy (due to stone).. 36.2. |
Case 36 | HR(−) HER2(−) Breast Cancer | 36.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and . cyclophosphamide + #4 cycles. of docetaxel) + Operation + Post-operative. radiation therapy.. Operation. 267. Pathology Report. . 1. No residual tumor with foamy histiocytic. collection.. . (a) Post-chemotherapy status.. . ... | Important Radiologic Findings. 260 261 262. 263. HR(−) HER2(−) Breast Cancer. 704. . . . . E. S. Lee et al.. 705. . HR(−) HER2(−) Breast Cancer. 706. . After Neoadjuvant Chemotherapy. 264 265. 266. 36.3. | Patient History and Progress. Female/46 years old, pre-menopause.. Self-detected palpable mass lesion on left. axillary.. Family history of breast cancer, aunt. (maternal).. Hepatitis B virus carrier.. BRCA 1 and 2 mutation: Not detected, RET. VUS (variant of uncertain).. 36.2. |
Case 36 | Local Recurrence | 36.1. . Courses of Treatment. Right breast DCIS → Operation → Left breast. recurrence (DCIS).. Primary Treatment. 244. Operation. 245. Pathology Report. Ductal Carcinoma In Situ. . 1. Post mammotome biopsy status.. Local Recurrence. 818. . a. b. . . 2. Size of tumor: 0.2 cm, residual.. . 3. Nuclear grade: low.. . 4... | null | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected mass lesion on right breast 10. o’clock direction.. Outside result of biopsy: Papillary carcinoma. in situ.. No family history.. s/p bilateral breast augmentation.. BRCA 1 and 2 mutation: Not detected.. 36.2. |
Case 36 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. Estrogen. receptor. Strong (7/7). 3. >2/3. Progesterone. receptor. Intermediate. (5/7). 2. 1/3–2/3. Result. Intensity. Positive %. C-erbB2. Equivocal. (2+). Ki-67. Positive in. 10% of tumor. cells. SISH. Neg... | null | mellitus.. 36.2. |
Case 37 | Carcinoma In Situ | 37.1. . Courses of Treatment:. Operation. Operation. 173. 174. Pathology Report. Lobular carcinoma in situ. . 1. Size of tumor: 2.0 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. Skin: no involvement of tumor.. . 6. Surgical margins:. . (a) superior margin: posit... | Important Radiologic. Findings. 171. 172. 37.3. | Patient History and Progress. Female/46 years old, pre-menopause.. Screen detected mass lesion on left breast. 12 o’clock direction.. Outside result of biopsy: Lobular carcinoma. in situ.. No family history.. No comorbidities.. 37.2. |
Case 37 | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel & cyclophosphamide) +. Post-operative radiation therapy + Tamoxifen. 20 mg/day.. Operation. Left breast conserving surgery, sentinel lymph. ductal component: present).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) sup... | Important Radiologic. Findings. See Figs. 205, 206, 207 and 208.. 37.3. | 4–5 o’clock direction.. No family history.. Hypertension,. s/p. Lumbar. spine. disc. operation.. 37.2. |
Case 37 | HR(−) HER2(+) Breast Cancer | 37.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab. and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab.. 253. Pathology Report. Ductal Carcinoma In Situ. 1. Post-chemotherapy status.. 2. Size of tumor: 0.5 cm (ypTis).. 3. ... | Important Radiologic. Findings. 246 247. 248. Y. Kwon et al.. 567. . . . HR(−) HER2(+) Breast Cancer. 568. 37.3. . After Neoadjuvant. Chemotherapy. 249 250 251. 252. . Y. Kwon et al.. 569. . . . 37.4. | Patient History and Progress. Female/63 years old, post-menopause.. Self-detected nipple discharge on left breast.. No family history.. S/P Total hysterectomy, s/p right lung lobec. tomy (benign), diabetes mellitus.. 37.2. |
Case 37 | HR(−) HER2(−) Breast Cancer | 37.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Adjuvant. capecitabine.. Operation. 276. Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy status.. 2. Size of ... | Important Radiologic. Findings. 268 269 270. 271. . . . . . E. S. Lee et al.. 709. . After Neoadjuvant. Chemotherapy. 272 273 274. 275. 37.3. | Patient History and Progress. Female/46 years old, pre-menopause.. Self-detected palpable mass lesion on right breast.. Family history of breast cancer, aunt (maternal).. s/p myomectomy.. BRCA 1 and 2 mutation: Not detected.. 37.2. |
Case 37 | Local Recurrence | 37.1. . Courses of Treatment. Left breast DCIS→ Operation → Adjuvant ther. apy → Left breast recurrence (DCIS).. Primary Treatment. 249 250. 251. Operation. 252. Local Recurrence. 820. Pathology Report. Ductal Carcinoma In Situ. . 1. Size of tumor: 3.0 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: present..... | null | Patient History and Progress. Female/43 years old, pre-menopause.. Screen detected mass lesion on left breast 7. o’clock direction.. Outside result of biopsy: ductal carcinoma in. situ.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 37.2. |
Case 37 | Metastatic Breast Cancer | 37.1. . Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. Estrogen. receptor. Intermediate. (6/8). 2. 1/3–2/3. Progesterone. receptor. Intermediate. (6/8). 2. 1/3–2/3. C-erbB2. Positive (3+). Ki-67. Positive in. 27% of tumor. cells. Metastatic Breast Cance... | null | Patient History and Progress. Female/59 years old, post-menopause.. No family history.. Hypertension, s/p right vertebral artery, tran. sient ischemic attack.. 37.2. |
Case 38 | Carcinoma In Situ | 38.1. . Courses of Treatment. Neoadjuvant chemotherapy #6 cycles (Docetaxel. and. Carboplatin. and. Trastuzumab. and. Pertuzumab) + Operation + Postoperative radia. tion therapy + Tamoxifen 20 mg/day for 5 years. + Trastuzumab for 1 year.. Operation. 180. 181. Pathology Report. Right.. Lobular carcinoma in situ. . 1.... | Important Radiologic. Findings. 175 176 177 178. 179. 38.3. | Patient History and Progress. Female/51 years old, pre-menopause.. Screen detected mass and microcalcification. on upper outer left breast.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected, POLE. VUS (variant of uncertain).. 38.2. |
Case 38 | HR(+) HER2(-) Breast Cancer | 38.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Letrozole 2.5 mg/day.. HR(+) HER2(−) Breast Cancer. extensive intraductal component: present).. 5. Skin: no involvement of tumor.. 6. Surgical margins:. . (a) superior margin: 20 mm.. . (b) inferior margin: 7 mm.. . (c) medial margi... | Important Radiologic. Findings. See Figs. 210, 211, 212, 213 and 214.. 38.3. | Patient History and Progress. Female/57 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. No family history.. Diabetes mellitus, dyslipidemia, s/p cataract. operation.. 38.2. |
Case 38 | HR(−) HER2(+) Breast Cancer | 38.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of docetaxel and cyclophosphamide) +. Post-operative. radiation. therapy. +. Trastuzumab.. 258. Y. Kwon et al.. 571. . . . HR(−) HER2(+) Breast Cancer. 3. Intraductal component: present, intratu. moral/extratumoral (60%) (nuclear grade:. h... | Important Radiologic. Findings. 254 255 256. 257. 38.3. | Patient History and Progress. Female/55 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. Family history of breast cancer, sister.. Dyslipidemia.. BRCA 1 and 2 mutation: Not detected,. MUTYH. and. RAD50 VUS. (variant. of. uncertain).. 38.2. |
Case 38 | HR(−) HER2(−) Breast Cancer | 38.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy.. Operation. . 285. 286. Pathology Report. No residual tumor with stromal degeneration. . 1. Post-chemotherapy status.. . 2. Lymph... | Important Radiologic. Findings. 277 278 279. 280. . . . . E. S. Lee et al.. 713. . After Neoadjuvant. Chemotherapy. 281 282 283. 284. 38.3. | Patient History and Progress. Female/52 years old, post-menopause.. Self-detected palpable mass lesion on right. breast.. No family history.. s/p bilateral salpingo-oophorectomy.. BRCA 1 mutation carrier.. 38.2. |
Case 38 | Local Recurrence | 38.1. . Courses of Treatment. Right breast IDC→ Operation → Adjuvant ther. apy → Right breast DCIS.. Primary Treatment. Operation. Jun. 2012 Right breast conserving surgery, senti. nel lymph node biopsy (outside).. Pathology Report. Invasive Ductal Carcinoma. . 1. Size of tumor: 0.9 cm (pT1b).. . 2. Lymph nodes: n... | null | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. Outside result of Lumpectomy: Invasive duc. tal carcinoma.. No family history.. Y. Kim et al.. 823. 38.2. |
Case 38 | Metastatic Breast Cancer | Courses of Treatment. Both breasts cancer → Operation → Adjuvant. therapy → Liver metastasis.. Primary Treatment. See Figs. 119 and 120.. Operation. Dec. 2008 Bilateral breast conserving surgery,. axillary lymph node dissection.. Pathology:. Right breast> Invasive ductal carcinoma, stage. pT2N2a, size of tumor: 4.5 cm,... | null | |
Case 39 | Carcinoma In Situ | 39.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 6 months.. Operation. 184. 185. Pathology Report. Lobular carcinoma in situ. . 1. Size of tumor: 2.0 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. E. S. Lee et al.. 137. . 4. Architectural pattern: solid.. . 5. Skin: no involvement of tumo... | Important Radiologic. Findings. 182. 183. 39.3. | Patient History and Progress. Female/47 years old, pre-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. Outside result of biopsy: lobular carcinoma in. situ.. No family history.. Hypertension.. 39.2. |
Case 39 | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & cyclophospha. mide) + Tamoxifen 20 mg/day.. Operation. Right nipple–areolar complex sparing mastec. tomy with immediate implant reconstruction, left. breast mass excision (Figs. 220, 221 and 222).. Pathology Report. [Right]. Invasi... | Important Radiologic. Findings. See Figs. 216, 217, 218 and 219.. 39.3. | No comorbidities.. 39.2. |
Case 39 | Local Recurrence | 39.1. . Courses of Treatment. Left breast IDC→ Operation → Adjuvant ther. apy → Left breast recurrence (IDC).. Primary Treatment. 258 259 260. 261. Operation. 262. Pathology Report. Invasive Ductal Carcinoma. 1. Size of invasive tumor: 3 cm (pT2).. 2. Size of intraductal component: 4.5 cm.. 3. Histologic grade: 1/... | null | Patient History and Progress. Female/42 years old, post-menopause.. Bloody discharge from left nipple.. No family history.. 39.2. |
Case 39 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Left. breast and lung metastasis.. Primary Treatment. Estrogen. receptor. Negative(0/7). 0. 0. Progesterone. receptor. Negative(0/7). 0. 0. C-erbB2. Equivocal (2+). Ki-67. Positive in. 10% of tumor. cells. SISH. Neg... | null | Patient History and Progress. Female/51 years old, peri-menopause.. No family history.. BRCA 1 & 2 mutation: Not detected.. Hepatitis B virus carrier, hypertension.. 39.2. |
Case 4 | Benign and Proliferative | 4.1. . Courses of Treatment. → 2021-12-14 Excision, Lt.. Benign and Proliferative Case Series. 22. . 4.3.1. . Pathology Report. Diagnosis. • Breast, left, excision:. –. – Intraductal papilloma.. 5. | Important Radiologic. Findings. 6. 4.3. | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass lesion on left breast. 12 o’clock direction.. Family history of pancreatic cancer, mother.. Hypertension, dyslipidemia (taking medication).. 4.2. |
Case 4 | Carcinoma In Situ | 4.1. . Courses of Treatment. Operation + Postoperative radiation therapy (left. side) + Tamoxifen 20 mg/day for 5 years.. 4.3.1. . Operation. 19. 20. 4.3.2. . Pathology Report. Right.. <First operation>. Lobular carcinoma in situ. . 1. Size of tumor: 0.2 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4.... | Important Radiologic. Findings. 15 16 17. 18. 4.3. | Patient History and Progress. Female/46 years old, pre-menopause.. Self-detected palpable mass on right breast 8. and 9 o’clock direction.. No family history.. No comorbidities.. BRCA 1 and 2: No detected mutation,. RAD51C VUS (variant of uncertain).. 4.2. |
Case 4 | HR(+) HER2(+) Breast Cancer | 4.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Letrozole 2.5 mg/day.. 23. 4.3.1. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 0.6 cm (pT1b).. 2. Histologic grade: 3/3 (tubule formati... | Important Radiologic. Findings. 19 20 21. 22. 4.3. | Patient History and Progress. Female/56 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. No family history.. S/P Thyroid radiofrequency ablation.. 4.2. |
Case 4 | HR(+) HER2(-) Breast Cancer | high, necrosis: present, architectural pattern:. solid/comedo, extensive intraductal compo. nent: absent).. 4. Skin: no involvement of tumor.. 5. Surgical margins:. . (a) superior margin: 10 mm,. . (b) inferior margin: (see note),. . (c) medial margin: 10 mm,. . (d) lateral margin: 15 mm,. . (e) deep margin: 2 ... | Important Radiologic. Findings. See Figs. 15, 16, 17 and 18.. HR(+) HER2(−) Breast Cancer | Dyslipidemia.. 4.2. |
Case 4 | HR(−) HER2(+) Breast Cancer | 4.1. . Courses of Treatment. Neoadjuvant chemotherapy (#6 cycles of. docetaxel and carboplatin and trastuzumab and. pertuzumab) + Operation + Post-operative radia. tion therapy.. 4.4.1. . Operation. 35. 4.4.2. . Pathology Report. . 1. No residual tumor with stromal fibrosis.. . (a) Post-chemotherapy status.. . (b... | Important Radiologic. Findings. 27 28 29. 30. . Y. Kwon et al.. 443. . . . F. ig. 30. 34. . . . . . . Y. Kwon et al.. 445. 4.4. | Patient History and Progress. Female/58 years old, post-menopause.. Self-detected mass lesion on left breast 3:30. o’clock direction.. No family history.. No comorbidities.. 4.2. |
Case 4 | HR(−) HER2(−) Breast Cancer | 4.1. . Courses of Treatment. Operation + adjuvant chemotherapy (#4 cycles. of docetaxel and cyclophosphamide) + Post-. operative radiation therapy.. 4.3.1. . Operation. 26. 4.3.2. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 (tubule formation: 2/3,. n... | Important Radiologic. Findings. 22 23 24. 25. HR(−) HER2(−) Breast Cancer. 586. . . . E. S. Lee et al.. 587. . 4.3. | Patient History and Progress. Female/52 years old, post-menopause.. Self-detected palpable mass lesion on left. breast 1–2 o’clock direction.. No family history.. Hyperthyroidism.. 4.2. |
Case 4 | Local Recurrence | 4.1. . Courses of Treatment. Left breast Invasive cribriform carcinoma →. Operation → Adjuvant therapy → Left chest. wall recurrence (IDC).. 4.2.1. . Primary Treatment. 22 23. 24. Operation. . 25. 26. Pathology Report. Invasive Cribriform Carcinoma. 1. Size of invasive component: 1.5 cm and. 0.5 cm (pT1c).. 2. Si... | null | Patient History and Progress. Female/41 years old, pre-menopause.. Screen detected mass lesion on left breast 1. and 2 o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 4.2. |
Case 4 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Left breast and pleural effusion. recurrence.. 4.2.1. . Primary Treatment. Operation. Oct. 2008 Right breast conserving surgery, axil. lary lymph node dissection.. Pathology: Invasive ductal carcinoma, stage. T1(m)N1 (2/25).. Size of tumor: 1... | null | BRCA 1 mutation: detected.. s/p Appendectomy, s/p myomectomy.. 4.2. |
Case 40 | Carcinoma In Situ | 40.1. . Courses of Treatment:. Operation. Operation. 189. 190. Pathology Report. Lobular carcinoma in situ. . 1. Post-stereotactic excision status.. . 2. Size of tumor: 1.0 cm, residual.. . 3. Nuclear grade: low.. E. S. Lee et al.. 139. . 4. Necrosis: absent.. . 5. Architectural pattern: solid.. . 6. Skin: no in... | Important Radiologic. Findings. 186 187. 188. 40.3. | Patient History and Progress. Female/47 years old, post-menopause.. Screen detected mass and microcalcification. on right breast 10 o’clock direction.. No family history.. No comorbidities.. 40.2. |
Case 40 | Local Recurrence | 40.1. . Courses of Treatment. Right breast DCIS→ Operation → Right breast. recurrence (microinvasive ductal carcinoma).. Primary Treatment. 266. Local Recurrence. 828. . . Operation. 267. Pathology Report. Ductal Carcinoma In Situ. . 1. Size of tumor: 0.3 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.... | null | Patient History and Progress. Female/60 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock and 9 o’clock direction.. Outside result of biopsy: right breast 12. o’clock, Atypical ductal hyperplasia.. Right breast 9:30 o’clock, Fibrocystic change.. Family history of breast cancer, older s... |
Case 40 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Lung. metastasis.. Primary Treatment. 3. >2/3. Progesterone. receptor. Strong (8/8). 3. >2/3. C-erbB2. Negative (0). Ki-67. Positive in. 76% of tumor. cells. Neoadjuvant Chemotherapy. Neoadjuvant chemotherapy #8 cyc... | null | |
Case 41 | Carcinoma In Situ | 41.1. . Courses of Treatment. 194. 195. Operation + Tamoxifen 20 mg/day for 5 years.. Operation. 194. 195. Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 1.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Archite... | Important Radiologic. Findings. 191 192. 193. 41.3. | Patient History and Progress. Female/46 years old, pre-menopause.. Screen detected mass lesion on left breast. 2 o’clock direction.. Outside result of biopsy: R/O Atypical ductal. hyperplasia or ductal carcinoma in situ.. No family history.. No comorbidities.. 41.2. |
Case 41 | Local Recurrence | 41.1. . Courses of Treatment. Left breast IDC → Operation → Adjuvant ther. apy → Right breast recurrence (DCIS).. Primary Treatment. 272 273. 274. Operation. 275. Pathology Report. Invasive Ductal Carcinoma. 1. Size of invasive tumor: 1.2 cm (pT1c).. 2. Size of ductal carcinoma in situ: 3.5 cm.. 3. Histologic grad... | null | Patient History and Progress. Female/62 years old, post-menopause.. Screen detected mass lesion on left breast sub. areolar and retraction of left nipple.. No family history.. No comorbidities.. 41.2. |
Case 41 | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Lung, liver, and bone metastasis.. Primary Treatment. Strong (7/8). 3. 1/3–2/3. Progesterone. receptor. weak (4/8). 2. 1–10%. C-erbB2. Positive. (+3). Ki-67. Positive in. 19% of. tumor cells. Adjuvant Therapy. Adjuvant chemotherapy # 8 cycles (D... | null | Patient History and Progress. Female/52 years old, peri-menopause.. No family history.. S/p Tuberculosis.. 41.2. |
Case 42 | Carcinoma In Situ | 42.1. . Courses of Treatment. Operation + Postoperative radiation therapy.. Operation. 200. 201. Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTisNx. . 1. Size of tumor: 1.5 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: papillary/c... | Important Radiologic. Findings. 196 197 198. 199. 42.3. | Patient History and Progress. Female/57 years old, post-menopause.. Screen detected microcalcification on left. breast 6 o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. Diabetes mellitus.. 42.2. |
Case 42 | Local Recurrence | 42.1. . Courses of Treatment. Left breast ILC → Operation → Adjuvant ther. apy → Right breast recurrence (IDC).. Primary Treatment. 280. Operation. Aug. 2017 Left nipple-areolar complex sparing. mastectomy with transverse rectus abdominis. muscles flap reconstruction (outside).. Pathology Report. Invasive Lobular Car... | null | Patient History and Progress. Female/52 years old, pre-menopause.. Screen detected mass lesion on right breast 10. o’clock direction.. Outside result of biopsy: Invasive ductal. carcinoma.. Family history of breast cancer, younger sister. at her 44 years old.. s/p Left breast Nipple sparing mastectomy. (invasive lobula... |
Case 42 | Metastatic Breast Cancer | . Courses of Treatment. Left breast cancer → Operation → Adjuvant. therapy → Lung metastasis.. Primary Treatment. Progesterone. receptor. Strong (7/7). 3. >2/3. C-erbB2. Equivocal (2+). Ki-67. Positive in 5%. of tumor cells. FISH. Negative. Adjuvant Therapy. Adjuvant chemotherapy # 6 cycles (Fluorouracil-5. & Doxorubi... | null | Patient History and Progress. Female/57 years old, post-menopause.. No family history.. Arrhythmia (taking on medicine).. 42.2. |
Case 43 | Brief Overview of Breast Cancer Treatment | Brief Overview of Breast Cancer Treatment. 150. . (b) Multicentric or multifocal lesions or with. an extensive intraductal component of. 25% or greater and tumor size that is sig. nificantly reduced after neoadjuvant. therapy.. . (c) A lesion significantly reduced in size. after neoadjuvant therapy that is a T1 or. ... | null | null |
Case 43 | Carcinoma In Situ | 43.1. . Courses of Treatment. Operation + Postoperative radiation therapy (left).. E. S. Lee et al.. 145. . . . . Operation. 206. 207. Pathology Report. Right.. Lobular carcinoma in situ. . 1. Size of tumor: 0.3 cm.. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: solid.. . 5. Skin... | Important Radiologic. Findings. 202 203 204. 205. 43.3. | Patient History and Progress. Female/67 years old, post-menopause.. Screen detected mass lesion on left breast 4. o’clock direction.. Outside result of biopsy: Ductal carcinoma in. situ.. No family history.. Diabetes mellitus, hypertension.. 43.2. |
Case 43 | Local Recurrence | 43.1. . Courses of Treatment. Right breast ILC→ Operation → Adjuvant ther. apy → Left breast recurrence (microinvasive. ductal carcinoma).. Primary Treatment. 285. 286. Operation. . 287. Pathology Report. Invasive Lobular Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 2/3 (tubule formation: 3/3,... | null | Patient History and Progress. Female/64 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. Outside result of biopsy: Invasive ductal. carcinoma.. Family history of breast cancer, older sister.. Diabetes mellitus, fatty liver, dyslipidemia.. BRCA 1 and 2 mutation: Not detecte... |
Case 43 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Operation → Adjuvant. therapy → Brain metastasis.. Primary Treatment. receptor. Strong (7/7). 3. >2/3. Progesterone. receptor. Strong (7/7). 3. >2/3. C-erbB2. Negative. (1+). Ki-67. Positive in. 8% of tumor. cells. Adjuvant Therapy. Post-operation radiation to right breast +.... | null | BRCA 1 & 2 mutation: Not detected.. S/p bilateral salpingo-oophorectomy.. 43.2. |
Case 44 | Local Recurrence | 44.1. . Courses of Treatment. Left breast microinvasive ductal carcinoma →. Operation → Adjuvant therapy → Right breast. recurrence (IDC).. Primary Treatment. 293 294 295. 296. . . . . . . Local Recurrence. 840. Operation. . 297. Pathology Report. Microinvasive Ductal Carcinoma. 1. Size of invasive component: <0.1 ... | null | Patient History and Progress. Female/54 years old, post-menopause.. Screen detected mass lesion on left breast 2. o’clock direction.. Outside result of biopsy: Ductal carcinoma.. No family history.. No comorbidities.. 44.2. |
Case 44 | Metastatic Breast Cancer | 44.1. . Courses of Treatment. Right breast cancer with bone metastasis →. Palliative therapy.. Progesterone. receptor. Negative. (0/8). 0. 0. C-erbB2. Negative. (1+). Ki-67. Positive in. 57% of. dissection.. Pathology: Invasive ductal carcinoma, stage. ypT1cN1a.. Size of tumor: 2.0 cm, lymph node: 3/7. (2 mm).. Resul... | null | Patient History and Progress. Female/49 years old, post-menopause.. No family history.. S/p bilateral salpingo-oophorectomy.. 44.2. |
Case 45 | Local Recurrence | 45.1. . Courses of Treatment. Right breast LCIS→ Operation → Right breast. recurrence (DCIS).. Primary Treatment. 303. Operation. 304. 305. Pathology Report. <Right>. Y. Kim et al.. 843. . 1. Lobular Carcinoma In Situ. . (a) Size of tumor: up to 0.4 cm, multifocal. (pTis).. . (b) Surgical margins:. • Superior marg... | null | Patient History and Progress. Female/57 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. Outside result of biopsy: Lobular carcinoma. in situ.. Family history of breast cancer, older sister.. Panic disorder.. BRCA 1 and 2 mutation: Not detected.. 45.2. |
Case 45 | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer with lung and bone metas. tasis → Palliative therapy.. See Figs. 137, 138, and 139.. Left invasive ductal carcinoma, stage IV. (metastasis in lung, bone).. Result. Intensity. Positive %. Estrogen. receptor. Strong (8/8). 3. >2/3. Progesterone. receptor. Negative. (2/8). 1. <1%.... | null | |
Case 46 | Local Recurrence | 46.1. . Courses of Treatment. Right breast papillary carcinoma in situ →. Operation → Adjuvant therapy → Right breast. recurrence (IDC).. Primary Treatment. Operation. 308. Pathology Report. Papillary Carcinoma In Situ in background of. multiple papilloma (see note). . 1. Size of intraductal carcinoma: 0.5 cm. (pTis... | null | Patient History and Progress. Female/69 years old, post-menopause.. Screen detected mass lesion on upper outer. portion of right breast.. No family history.. No comorbidities.. 46.2. |
Case 46 | Metastatic Breast Cancer | 46.1. . Courses of Treatment. Right breast cancer with bone metastasis →. Palliative therapy.. See Figs. 140 and 141.. Metastatic Breast Cancer. 934. Right invasive ductal carcinoma, Stage IV. (R/O metastasis in bone, T-spine 10).. Result. Intensity. Positive %. Estrogen. receptor. Strong (8/8). 3. >2/3. Progesterone.... | null | Patient History and Progress. Female/61 years old, post-menopause.. No family history.. s/p appendectomy, hypertension.. 46.2. |
Case 47 | Local Recurrence | 47.1. . Courses of Treatment. Right breast Infiltrating ductal carcinoma→. Operation → Adjuvant therapy → Left breast. recurrence (IDC).. Primary Treatment. 314. 315. Operation. Aug. 2003 Right breast conserving surgery, axil. lary lymph node dissection.. Pathology Report. Infiltrating ductal carcinoma.. 1. Size of ... | null | Patient History and Progress. Female/72 years old, post-menopause.. Screen detected mass lesion on right breast 1. o’clock direction.. No family history.. Diabetes mellitus.. BRCA 1 and 2 mutation: Not detected, ATM. VUS (variant of uncertain).. POLE VUS (variant of uncertain).. 47.2. |
Case 47 | Metastatic Breast Cancer | 47.1. . Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Ipsilateral. breast recurrence → Lung metastasis.. Primary Treatment. receptor. Negative 0/8). 0. 0. C-erbB2. Positive (3+). Ki-67. Positive in 5%. Operation. Aug. 2013 Left breast conserving surgery, senti... | null | Patient History and Progress. Female/46 years old, pre-menopause.. No family history.. 47.2. |
Case 48 | Local Recurrence | 48.1. . Courses of Treatment. Left breast Mucinous carcinoma → Operation. → Adjuvant therapy → Left breast recurrence. (mucinous carcinoma).. Primary Treatment. 320. 321. Operation. 322. Pathology Report. Mucinous Carcinoma. 1. Size of invasive carcinoma: 0.6 cm (pT1b).. 2. Size of intraductal carcinoma: 1.5 cm.. 3.... | null | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected mass lesion on left breast 9. o’clock direction.. Outside. result. of. biopsy:. Mucinous. carcinoma.. No family history.. No comorbdities.. 48.2. |
Case 48 | Metastatic Breast Cancer | 48.1. . Courses of Treatment. Right breast cancer with mediastinum and. bone metastasis → Palliative therapy.. Progesterone. receptor. Intermediate. (5/8). 2. 10%–1/3. C-erbB2. Negative (0). Ki-67. Positive in. 54% of tumor. cells. Neoadjuvant. chemotherapy. #8. cycles. (Doxorubicin + Cyclophosphamide #4 →. Docetaxel ... | null | Patient History and Progress. Female/45 years old, post-menopause.. No family history.. BRCA 1 & 2 mutation: Not detected.. S/p bilateral salpingo-oophorectomy.. 48.2. |
Case 49 | Local Recurrence | 49.1. . Courses of Treatment. Right breast IDC→ Operation → Adjuvant ther. apy → Left breast recurrence (IDC).. Primary Treatment. 328. 329. Operation. Apr. 2004 Right breast conserving surgery, senti. nel lymph node biopsy.. Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histolo... | null | Patient History and Progress. Female/63 years old, post-menopause.. Self-detected mass lesion on right breast. . 2 o’clock direction.. No family history.. No comorbidities.. BRCA 1 and 2 mutation: No examination.. Local Recurrence. 854. 49.2. |
Case 49 | Metastatic Breast Cancer | 49.1. . Courses of Treatment. Right breast cancer with bone metastasis →. Palliative therapy.. See Figs. 148 and 149.. Right invasive ductal carcinoma, stage IV. (metastasis in bone).. Metastatic Breast Cancer. Strong(8/8). 3. >2/3. C-erbB2. Negative. (1+). Ki-67. Positive in. 75% of. tumor cells. Clinical trial: Tamo... | null | Patient History and Progress. Female/55 years old, post-menopause.. No family history.. S/p bilateral salpingo-oophorectomy, s/p Left. pelvis cementoplasty.. 49.2. |
Case 5 | Benign and Proliferative | 5.1. . Courses of Treatment. →2021-12-17 Excision, Lt. (11H, 1H).. 5.3.1. . Pathology Report. • Breast, left, excision:. –. – Atypical ductal hyperplasia (#1. 1 o’clock. & #2. 11 o’clock) involving intraductal. papilloma with microcalcification.. C. W. Lee et al.. 23. . . 6. | Important Radiologic. Findings. 7. 8. 5.3. | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected microcalcification on upper. outer portion of left breast.. Family history of breast cancer, mother and. sister.. No comorbidities.. BRCA 1 and 2 mutation: Not detected.. 5.2. |
Case 5 | Carcinoma In Situ | Courses of Treatment. Operation + Postoperative radiation therapy.. 5.3.1. . Operation. 25. 26. 5.3.2. . Pathology Report. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.3 cm (pTis).. . 2. Nuclear grade: low.. . 3. Necrosis: absent.. . 4. Architectural pattern: crib... | Important Radiologic. Findings. 21 22 23. 24. 5.3. | Screen detected mass lesion on left breast 11,. 3 and 2 o’clock direction.. Outside result of biopsy:. Left breast 11 o’ clock: Intraductal prolifera. tive lesion.. Left breast 3 o’ clock: Adenosis and fibrocys. tic change.. Left breast 2 o’clock: Fibrocystic change.. No family history.. No comorbidities.. 5.2. |
Case 5 | HR(+) HER2(+) Breast Cancer | 5.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles. of. docetaxel. and. cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 28. 5.3.1. . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 1.5 cm (pT1c).. 2. Histologic grade: 3/3 ... | Important Radiologic. Findings. 24 25 26. 27. 5.3. | Patient History and Progress. Female/53 years old, peri-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. No family history.. Hypothyroidism, dyslipidemia, s/p cold knife. conization of cervix.. 5.2. |
Case 5 | HR(+) HER2(-) Breast Cancer | Courses of Treatment. Operation. +. Adjuvant. chemotherapy. (#4 cycles of docetaxel & cyclophospha. mide). +. Post-operative. radiation. ther. apy + Letrozole 2.5 mg/day.. 5.3.1. . Operation (1st, Dec. 2020). Right breast conserving surgery, sentinel lymph. low, necrosis: present, architectural pattern:. micropapil... | Important Radiologic. Findings. See Figs. 20, 21, 22 and 23.. 5.3. | o’clock direction.. No family history.. No comorbidities.. 5.2. |
Case 5 | HR(−) HER2(+) Breast Cancer | 5.1. . Courses of Treatment. Operation + Post-operative radiation therapy.. 5.3.1. . Operation. 40. 5.3.2. . Pathology Report. . 1. Invasive ductal carcinoma.. . (a) Size of invasive component: 0.2 cm. (pT1a).. . (b) Size of intraductal component: 2.0 cm.. . (c) Histologic grade: 3/3 (tubule formation:. 3/3, nu... | Important Radiologic. Findings. 36 37 38. 39. Y. Kwon et al.. 447. . . . HR(−) HER2(+) Breast Cancer. 448. . 5.3. | Patient History and Progress. Female/58 years old, post-menopause.. Screen detected mass lesion on upper inner. portion of left breast 8 o’clock.. No family history.. S/P myomectomy, dyslipidemia.. 5.2. |
Case 5 | HR(−) HER2(−) Breast Cancer | 5.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Adjuvant. capecitabine (refuse).. 5.3.1. . Operation. 35. 5.3.2. . Pathology Report. Invasive Ductal Carcinoma. 1. Post-chemotherapy st... | Important Radiologic. Findings. 27 28 29. 30. E. S. Lee et al.. 589. . . . HR(−) HER2(−) Breast Cancer. 590. . 5.2.1. . After Neoadjuvant. Chemotherapy. 31 32 33. 34. 5.3. | Patient History and Progress. Female/57 years old, post-menopause.. Screen detected a mass lesion on left breast 9. o’clock direction.. Family history of breast cancer, sister and. niece.. Family history of ovarian cancer, mother.. S/P. Hysterectomy,. s/o. bilateral. salpingo-oophorectomy.. BRCA 1 mutation carrier.. 5.... |
Case 5 | Local Recurrence | 5.1. . Courses of Treatment. Left breast IDC → Operation → Adjuvant ther. apy → Right breast recurrence (IDC).. 5.2.1. . Primary Treatment. 30 31. 32. Operation. 33. Y. Kim et al.. 729. . . . . . Pathology Report. Invasive Ductal Carcinoma. 1. Size of tumor: 2.0 cm (pT1c).. 2. Histologic grade: 3/3 (tubule format... | null | Patient History and Progress. Female/69 years old, post-menopause.. Screen detected mass lesion on left breast. . 2 o’clock direction.. No family history.. No other history of disease, operation, or. medication.. BRCA 1 VUS (variant of uncertain).. 5.2. |
Case 5 | Metastatic Breast Cancer | Courses of Treatment. Left breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy → Lung. and liver metastasis.. 5.2.1. . Primary Treatment. Jun. 2015 breast, left, needle biopsy:. Invasive ductal carcinoma, histologic grade 2. with apocrine differentiation.. Result. Intensity. Positive %. Estrogen... | null | 5.2. |
Case 50 | Local Recurrence | 50.1. . Courses of Treatment. Right breast IDC → Operation → Adjuvant. therapy → Right breast recurrence (IDC).. Primary Treatment. 334 335. 336. Operation. 337. 338. Pathology Report. <Right>. . 1. Invasive Ductal Carcinoma. . (a) Size of tumor: 1.8 cm (pT1c).. . (b) Histologic grade: 2/3 (tubule formation:. 2/3, ... | null | Patient History and Progress. Female/72 years old, post-menopause.. Screen detected mass lesion on right breast 12. o’clock and 8 o’clock direction, left breast 12. o’clock direction.. No family history.. Hypertension, hepatitis B virus carrier,. claustrophobia.. 50.2. |
Case 50 | Metastatic Breast Cancer | 50.1. . Courses of Treatment. Left breast cancer with lung metastasis →. Palliative therapy.. See Figs. 150 and 151.. Left invasive ductal carcinoma, stage IV. (metastasis. in. ovary,. s/p. bilateral. salpingo-oophorectomy).. Result. Intensity Positive %. Estrogen. receptor. Negative (0/8). 0. 0. Progesterone. recepto... | null | Patient History and Progress. Female/47 years old, post-menopause.. No family history.. S/p bilateral salpingo-oophorectomy, diabetes. mellitus.. 50.2. |
Case 6 | Benign and Proliferative | 6.1. . Courses of Treatment. → 2021-12-31 excision, both.. Benign and Proliferative Case Series. 24. . . 6.3.1. . Pathology Report. • Breast, right, excision:. –. – Intraductal papilloma with (1) usual ductal. hyperplasia, (2) microcalcification.. • Breast, left, excision:. –. – Intraductal papilloma with (1) usual... | Important Radiologic. Findings. 9. 10. 6.3. | Patient History and Progress. Female/48 years old, pre-menopause.. Bloody discharge from right nipple.. No family history.. Hypertension.. 6.2. |
Case 6 | Carcinoma In Situ | 6.1. . Courses of Treatment. Operation + Tamoxifen 20 mg/day for 5 years.. E. S. Lee et al.. 65. 6.3.1. . Operation. 28. 29. 6.3.2. . Pathology Report. <First operation>. Ductal carcinoma in situ, pathological TN cat. egory (AJCC 2017): pTis. . 1. Size of tumor: 0.3 cm (pTis).. . 2. Nuclear grade: low.. . 3. Nec... | Important Radiologic. Findings. 27. 6.3. | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected microcalcification on left. breast upper outer.. No family history.. s/p Lt mammotome biopsy in 2018 (result:. benign).. 6.2. |
Case 6 | HR(+) HER2(+) Breast Cancer | 6.1. . Courses of Treatment. Operation + Adjuvant chemotherapy (#4. cycles of doxorubicin and cyclophospha. mide). +. Post-operative. radiation. ther. apy + Trastuzumab + Tamoxifen 20 mg/day.. 35. 6.3.1. . Pathology Report. . 1. Invasive ductal carcinoma.. . (a) Size of tumor: 1.5 cm (pT1c).. . (b) Histologic ... | Important Radiologic. Findings. 29 30 31 32 33. 34. 6.3. | Patient History and Progress. Female/42 years old, pre-menopause.. Screen detected mass lesion on right breast 12. o’clock direction.. No family history.. Hypertension.. 6.2. |
Case 6 | HR(+) HER2(-) Breast Cancer | 6.1. . Courses of Treatment. Operation + Post-operative radiation ther. apy + Tamoxifen 20 mg/day.. 6.3.1. . Operation. Right breast conserving surgery, sentinel lymph. moral/extratumoral (60%) (nuclear grade:. low, necrosis: present, architectural pattern:. solid/comedo, extensive intraductal compo. nent: presen... | Important Radiologic. Findings. See Figs. 26, 27, 28 and 29.. 6.3. | Patient History and Progress. Female/51 years old, pre-menopause.. Screen detected mass lesion on right breast 2. o’clock direction.. No family history.. S/P Thyroid benign mass, excision.. 6.2. |
Case 6 | HR(−) HER2(+) Breast Cancer | Courses of Treatment. Neoadjuvant. chemotherapy. (#1. cycle. of. docetaxel and carboplatin and #6 cycles of trastu. zumab and pertuzumab) + Operation + Post-. operative radiation therapy + Trastuzumab +. Letrozole 2.5 mg.. 6.4.1. . Operation. 47. 6.4.2. . Pathology Report. . 1. No residual tumor with stroma... | Important Radiologic. Findings. 41 42. 43. HR(−) HER2(+) Breast Cancer. . Y. Kwon et al.. 451. 6.3. . After Neoadjuvant. Chemotherapy. 44 45. . HR(−) HER2(+) Breast Cancer. 452. 6.4. | S/P. cholecystectomy,. hypertension,. dyslipidemia.. BRCA 1 and 2 mutation: Not detected.. 6.2. |
Case 6 | HR(−) HER2(−) Breast Cancer | 6.1. . Courses of Treatment. Neoadjuvant chemotherapy (#4 cycles of. doxorubicin and cyclophosphamide + #4. cycles of docetaxel) + Operation + Post-. operative radiation therapy + Letrozole. 2.5 mg + Adjuvant capecitabine.. 6.3.1. . Operation. 43. . E. S. Lee et al.. 597. . 6.3.2. . Pathology Report. Ductal... | Important Radiologic. Findings. 36 37 38. 39. . HR(−) HER2(−) Breast Cancer. 594. . . . E. S. Lee et al.. 595. . . . . 6.2.1. . After Neoadjuvant. Chemotherapy. 40 41. 42. HR(−) HER2(−) Breast Cancer. 596. 6.3. | Patient History and Progress. Female/49 years old, pre-menopause.. Self-detected palpable mass lesion on left. breast.. No family history.. Panic disorder, lumbar spine disc.. 6.2. |
Case 6 | Local Recurrence | 6.1. . Courses of Treatment. Both breasts IDC→ Operation → Adjuvant. therapy → Left breast recurrence (IDC).. 6.2.1. . Primary Treatment. 38 39 40 41 42. 43. Operation. . 44. 45. Local Recurrence. 732. . . . . . . . Pathology Report. <Right>. Invasive Ductal Carcinoma. 1. Size of tumor: 1.2 cm (pT1c).. 2. Histol... | null | Patient History and Progress. Female/60 years old, post-menopause.. Bloody nipple discharge on left breast.. Screen detected mass lesion on right breast 6. o’clock direction and left breast 12 o’clock. direction.. No family history.. Hypertension.. 6.2. |
Case 6 | Metastatic Breast Cancer | Courses of Treatment. Right breast cancer → Neoadjuvant chemother. apy → Operation → Adjuvant therapy →. Ipsilateral breast and chest wall recurrence →. Palliative therapy → Progression on the skin. and contralateral axillary lymph nodes.. 6.2.1. . Primary Treatment. Aug. 2017 breast, left, needle biopsy:. Invasive d... | null | 6.2. |
Case 7 | Benign and Proliferative | 7.1. . Courses of Treatment. →2021-10-29 Rt upper, stereotactic biopsy.. 7.3.1. . Pathology Report. Diagnosis. • Breast, right upper, stereotactic biopsy:. –. – Atypical ductal hyperplasia (#1. Ca++). with microcalcification.. –. – Flat epithelial atypia (#2. no Ca++) with. microcalcification.. →2021-11-26 excision,... | Important Radiologic. Findings. 11. 7.3. | Patient History and Progress. Female/58 years old, post-menopause.. Screen detected microcalcification on upper. portion of right breast.. No family history.. No comorbidities.. 7.2. |
Case 7 | Carcinoma In Situ | 7.1. . Courses of Treatment. Operation + Postoperative radiation therapy +. Tamoxifen 20 mg/day for 5 years.. 7.3.1. . Operation. 32. 33. 7.3.2. . Pathology Report. Ductal carcinoma in situ. . 1. Post-mammotome excision status.. . 2. Size of tumor: 0.3 cm, residual.. . . . Carcinoma In Situ. 68. . 3. Nuclear grad... | Important Radiologic. Findings. 30. 31. E. S. Lee et al.. 67. 7.3. | Patient History and Progress. Female/48 years old, pre-menopause.. Screen detected mass lesion on right breast 1. and 9 o’clock direction.. Outside result of mammotome excision:. Right breast 1 o’clock, DCIS.. Right breast 9 o’clock, intraductal papilloma. with atypical ductal hyperplasia.. No family history.. No comor... |
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