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I don't see how to do that. Thank you. The NANDS, ME/CFS working group of council is composed of diverse
<|0.00|>I don't see how to do that.<|1.70|><|1.70|>Thank you. The NANDS, ME/CFS<|5.50|><|5.50|>working group of council is composed of diverse<|8.96|>
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a final report for the council in May of next year. In the meantime, after each of these
<|0.00|>a final report for the council<|3.72|><|3.72|>in May of next year.<|5.90|><|5.90|>In the meantime, after each of these<|9.16|>
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the webinar for our long discussion. With that introduction, I'd like to take this opportunity to introduce the
<|0.00|>the webinar for our long discussion.<|2.48|><|2.48|>With that introduction, I'd like to take this<|6.10|><|6.10|>opportunity to introduce the<|8.18|>
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by selecting the Q&A button at the bottom of the screen. We will be taking those questions. If you have a question specific to a
<|0.00|>by selecting the Q&A button at the bottom of the screen.<|3.58|><|3.58|>We will be taking those questions.<|7.20|><|7.20|>If you have a question specific to a<|9.52|>
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9.841
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and she much later continues to meet those challenges. She's a wife, mother of two children, and the
<|0.00|>and she much later continues to meet<|3.54|><|3.54|>those challenges. She's a wife, mother of two children,<|7.06|><|7.06|>and the<|8.24|>
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done tremendous work for many years on periphery brain cross talk, mechanisms pertaining to energy homeostasis, feeding behaviour. And recently, Lori was also
<|0.00|>done tremendous work for many years on periphery<|4.60|><|4.60|>brain cross talk, mechanisms pertaining to energy<|8.32|><|8.32|>homeostasis, feeding behaviour.<|10.06|><|10.06|>And recently, Lori<|13.84|><|13.84|>was also<|14.34|>
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sympathetic nervous system regulation of brown adipose tissue function. So please, Lori, the stage is yours. So I'd like to thank the organisers for
<|0.00|>sympathetic nervous system regulation of brown adipose tissue function.<|3.08|><|3.08|>So please, Lori, the stage is yours.<|6.42|><|6.42|>So I'd like to thank the organisers for<|9.20|>
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professor. So this little bit of an update to the introduction, and congratulations, and today we're going to hear about some interesting work. And I look forward to
<|0.00|>professor. So this little bit of an update to the<|3.54|><|3.54|>introduction, and congratulations, and today<|7.22|><|7.22|>we're going to hear about some interesting work.<|10.16|><|10.16|>And I look forward to<|11.52|>
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the trials and tribulations and progress that we've made in developing the tools and assays that are actually needed to study this appropriately. So I don't need to
<|0.00|>the trials and tribulations and progress that we've made in developing<|3.70|><|3.70|>the tools and assays that are actually needed to study this appropriately.<|8.32|><|8.32|>So I don't need to<|9.80|>
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observation really set off a whole cottage cottage industry of people who were looking to use bat activators as therapeutic anti obesity targets. And both
<|0.00|>observation really set off a whole cottage cottage<|3.74|><|3.74|>industry of people who were looking to use bat<|7.88|><|7.88|>activators as therapeutic anti obesity<|11.40|><|11.40|>targets. And both<|13.08|>
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shown here in brown, so they had lower glucose at baseline. Now this effect on glycaemia, was really pretty modest.
<|0.00|>shown here in brown, so they had lower<|3.50|><|3.50|>glucose at baseline. Now this effect on glycaemia, was<|7.50|><|7.50|>really pretty modest.<|8.90|>
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this coal stimulated glucose, glucose uptake was decreased in people with elevated BMI and obesity. And so this
<|0.00|>this coal stimulated glucose, glucose uptake was<|3.94|><|3.94|>decreased in people with elevated<|8.16|><|8.16|>BMI and obesity. And so this<|11.00|>
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published last a couple years ago now by Paul Cohen at Rockefeller. And what he did is they did a huge rent retrospective study of over 50,000 PET scans for
<|0.00|>published last a couple years ago now by Paul<|3.62|><|3.62|>Cohen at Rockefeller. And what he did is they did a huge<|7.18|><|7.18|>rent retrospective study of over 50,000<|11.82|><|11.82|>PET scans for<|13.94|>
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brown, brown adipose tissue activators are not sufficient to prevent obesity. As you can see, there are plenty of people who had BMI over 30 That in fact also have active fat.
<|0.00|>brown, brown adipose tissue activators are not sufficient<|3.62|><|3.62|>to prevent obesity.<|5.78|><|5.78|>As you can see, there are plenty of people who had BMI over<|9.50|><|9.50|>30 That in fact also have active fat.<|12.60|>
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is activated, it also generates heat. And so this is also been used. But while these studies have been really interesting and intriguing in humans, in the end, if you
<|0.00|>is activated, it also generates heat.<|2.14|><|2.14|>And so this is also been used.<|4.00|><|4.00|>But while these studies have been really<|7.54|><|7.54|>interesting and intriguing in humans, in the end, if you<|11.02|>
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he stratified by BMI, now you can see an interaction between the bat and the elevated BMI we're at. At low BMI eyes,
<|0.00|>he stratified by BMI, now you can see<|3.52|><|3.52|>an interaction between the bat and the elevated<|7.30|><|7.30|>BMI we're at. At low BMI<|11.22|><|11.22|>eyes,
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only see you don't really see any effect of the brown adipose tissue activity, but at the high BMI, now, you will start to see a protective effect where those individuals had lower
<|0.00|>only see you don't really see any effect of the brown<|3.76|><|3.76|>adipose tissue activity, but at the high BMI, now,<|7.26|><|7.26|>you will start to see a protective effect where<|10.78|><|10.78|>those individuals had lower<|14.04|>
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been done in thermo regulatory circuits has either focused on the circuits in the brain which have been written now the populations in some populations regulating thermal
<|0.00|>been done in thermo regulatory circuits has either focused<|3.50|><|3.50|>on the circuits in the brain which have been written now<|7.16|><|7.16|>the populations in some populations regulating thermal<|11.58|>
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hypothalamus, this, these signals then get relayed into the hindbrain and out through the intermediate lateral
<|0.00|>hypothalamus, this, these signals then get relayed<|4.08|><|4.08|>into the hindbrain and out<|7.86|><|7.86|>through the intermediate lateral<|10.98|>
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rather the projection from the sympathetic ganglion out to brown adipose tissue. And so there have been because of this link between BMI, elevated BMI, diabetes, impaired
<|0.00|>rather the projection from the sympathetic ganglion<|3.82|><|3.82|>out to brown adipose tissue.<|5.46|><|5.46|>And so there have been because of this link between<|9.44|><|9.44|>BMI, elevated BMI, diabetes, impaired<|12.72|>
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tissue functioning. So there have been many groups that have used animal models to try to understand what is the link between elevated BMI and impaired at impaired
<|0.00|>tissue functioning. So there have been many groups that have<|3.62|><|3.62|>used animal models to try to understand what is<|7.26|><|7.26|>the link between elevated BMI and impaired<|12.08|><|12.08|>at impaired<|13.36|>
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bring new gene therapies to market. The research is focused on understanding the molecular basis of neurodegenerative disorders and development of novel therapies to treat inherited
<|0.00|>bring new gene therapies to market.<|2.22|><|2.22|>The research is focused on understanding the molecular<|6.22|><|6.22|>basis of neurodegenerative disorders and development<|9.72|><|9.72|>of novel therapies to treat inherited<|11.72|>
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to reduce the presence of that toxic protein and the messenger RNA that encodes it. There's a number of different approaches that are out there. I'm not going to
<|0.00|>to reduce the presence of that toxic protein<|4.06|><|4.06|>and the messenger RNA that encodes it.<|6.70|><|6.70|>There's a number of different approaches that are out there.<|10.08|><|10.08|>I'm not going to<|10.74|>
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all of these, but I think it's important to know that various groups are targeting the mutant protein for enhancing degradation. Examples include shepherding it to the
<|0.00|>all of these, but I think it's important to know that various<|5.04|><|5.04|>groups are targeting the mutant protein for enhancing<|8.74|><|8.74|>degradation. Examples include shepherding<|12.96|><|12.96|>it to the
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as well as therapeutics have since put on hold and no longer moving forward. There are clinical trials using RNA interference in a non allele specific way, which will
<|0.00|>as well as therapeutics have since put on hold<|3.82|><|3.82|>and no longer moving forward.<|6.78|><|6.78|>There are clinical trials using RNA interference<|10.46|><|10.46|>in a non allele specific way, which<|14.02|><|14.02|>will
00:00:00.000
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very, very large expansions such as seen in Fragile X and myotonic dystrophy, and the smaller expansions we see in the coding axons for Huntington's disease and
<|0.00|>very, very large expansions such as seen in Fragile X and<|3.68|><|3.68|>myotonic dystrophy, and the smaller expansions we<|7.26|><|7.26|>see in the coding axons for Huntington's<|11.34|><|11.34|>disease and<|12.50|>
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There are a number of approaches up until recently that; were in the clinic that involved antisense ASOs. As some may be aware, antisense oligonucleotide programs spearheaded by
<|0.00|>There are a number of approaches up<|4.14|><|4.14|>until recently that; were in the clinic that involved antisense ASOs.<|8.28|><|8.28|>As some may be aware, antisense<|12.90|><|12.90|>oligonucleotide programs spearheaded by<|15.98|>
00:00:00.443
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therapies for mental health disorders. These are my disclosures. As mentioned briefly by Alexander. So I want to focus the first part of my presentation on repeat expansion
<|0.00|>therapies for mental health disorders.<|2.28|><|2.28|>These are my disclosures.<|5.22|><|5.22|>As mentioned briefly by Alexander.<|8.50|><|8.50|>So I want to focus the<|12.84|><|12.84|>first part of my presentation on repeat expansion<|16.82|>
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provide reduction in the transcripts and hopeful this will be therapeutically relevant to HD patients. But what I want to focus on today is not going after the protein
<|0.00|>provide reduction in the transcripts and hopeful this<|4.78|><|4.78|>will be therapeutically relevant to HD patients.<|8.44|><|8.44|>But what I want to focus on today is not going<|12.00|><|12.00|>after the protein<|12.96|>
00:00:00.000
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thought it very important to think about where we should focus the deletions of the mutant gene. There were two recent papers that came out of Joe Bait's lab and David House's
<|0.00|>thought it very important to think about where we<|3.62|><|3.62|>should focus the deletions of the mutant gene.<|7.16|><|7.16|>There were two recent papers that came out of Joe<|10.76|><|10.76|>Bait's lab and David House's<|14.32|>
00:00:00.000
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regions similar to what occurs in other microsatellite diseases, these repeat expansions can actually give rise to aberrant transcription and translation. This is known as RAN translation
<|0.00|>regions similar to what occurs in other microsatellite<|3.70|><|3.70|>diseases, these repeat expansions can actually give rise<|7.30|><|7.30|>to aberrant transcription and translation.<|11.08|><|11.08|>This is known as RAN translation<|13.14|>
00:00:00.000
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this mutant exon 1 protein that may be pathogenic. In addition to David and Julie's studies was the finding from Laura Random's lab where she identified that these repeat
<|0.00|>this mutant exon 1 protein that may be pathogenic.<|3.40|><|3.40|>In addition to David<|7.24|><|7.24|>and Julie's studies was the finding from Laura<|10.84|><|10.84|>Random's lab where she identified that these repeat<|14.44|>
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guides as you can see indicated by intro 3 and 4 guides or upstream guides steps 1 through 6. You can see very effective silencing of Huntington expression levels on
<|0.00|>guides as you can see indicated by intro 3<|3.72|><|3.72|>and 4 guides or upstream guides steps 1 through 6.<|7.46|><|7.46|>You can see very effective silencing of Huntington<|11.02|><|11.02|>expression levels on<|12.30|>
00:00:00.000
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lines that just happened to contain many SNPs that were surveyed among HD patient samples. And so we tested a number of different guide pairs, upstream guides and downstream
<|0.00|>lines that just happened to contain many SNPs that<|4.18|><|4.18|>were surveyed among HD patient samples.<|7.54|><|7.54|>And so we tested a number of different guide pairs,<|11.52|><|11.52|>upstream guides and downstream<|14.20|>
00:00:00.000
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denoted by the red arrows. And then the simultaneous decrease in the protein that you see on the western blot over on the right and quantified in the lower bar graph below. This was
<|0.00|>denoted by the red arrows.<|1.60|><|1.60|>And then the simultaneous<|6.02|><|6.02|>decrease in the protein that you see on the western blot<|9.88|><|9.88|>over on the right and quantified in the lower bar<|13.82|><|13.82|>graph below. This was<|16.18|>
00:00:01.178
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editing. Fortunately we found a number of SNPs that seemed to be linked to mutant allele that would give us a handle for allele specific editing. So if we combine the upstream
<|0.00|>editing. Fortunately we found a number of<|3.58|><|3.58|>SNPs that seemed to be linked to mutant<|7.10|><|7.10|>allele that would give us a handle for allele specific editing.<|10.90|><|10.90|>So if we combine the upstream<|13.30|>
00:00:00.464
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UTR very close to the promoter region and look for single nucleotide polymorphisms that were linked to mutant allele that would give rise to a PAM motif that would allow
<|0.00|>UTR very close to the promoter region and look for single<|3.76|><|3.76|>nucleotide polymorphisms that were linked to<|7.40|><|7.40|>mutant allele that would give rise to a PAM<|11.02|><|11.02|>motif that would allow<|12.24|>
00:00:00.000
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with the downstream PAM, the idea would be that would promote exon 1 deletion in the mutant allele only and leaving the normal allele intact. We first tested in
<|0.00|>with the downstream PAM, the idea would be that would promote<|3.56|><|3.56|>exon 1 deletion in the mutant allele only and leaving<|7.42|><|7.42|>the normal allele intact. We first<|10.98|><|10.98|>tested in<|11.76|>
00:00:00.000
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11.829
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suggested that the SNPs were useful and could be used for active editing. And next we moved into Huntington cells. So these are cells derived from Huntington patients that
<|0.00|>suggested that the SNPs were useful and could be used for active<|3.88|><|3.88|>editing. And next we moved<|7.52|><|7.52|>into Huntington cells.<|9.58|><|9.58|>So these are cells derived from Huntington patients that<|13.34|>
00:00:00.000
00:00:13.459
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This is high-energy X-rays, photons that's capable of ionizing atoms and molecules, and breaking chemical
<|0.00|>This is high-energy X-rays,<|3.52|><|3.52|>photons that's capable of ionizing atoms and<|7.08|><|7.08|>molecules, and breaking chemical<|8.42|>
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This can be rays that come from the cosmos, this can be rays that are generated by electricity, and equipment,
<|0.00|>This can be rays that come from the cosmos,<|3.54|><|3.54|>this can be rays that are generated by electricity, and<|7.30|><|7.30|>equipment,<|8.10|>
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Before I delve into the secrets and principles of CNS radiotherapy, I want to give an overview of radiotherapy
<|0.00|>Before I delve into the secrets and<|3.58|><|3.58|>principles of CNS radiotherapy, I want to give an<|7.14|><|7.14|>overview of radiotherapy<|8.42|>
00:00:00.527
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that I'm going to make later. When we talk about radiation, specifically medical radiotherapy, we're talking about ionizing
<|0.00|>that I'm going to make later. When we talk about radiation,<|3.80|><|3.80|>specifically medical radiotherapy, we're talking<|7.64|><|7.64|>about ionizing<|9.18|>
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which is shown on the bottom on the x-axis, on the figure on your left, you see dose
<|0.00|>which is shown on the bottom on the x-axis, on the figure on<|4.38|><|4.38|>your left, you see dose<|6.82|>
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I'll be very specific because I'm talking about treating tumors for the most part. As a function of
<|0.00|>I'll be very specific because I'm talking about treating tumors for<|3.92|><|3.92|>the most part. As a function of<|5.68|>
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on causing damage to DNA. The means by which we can actually use this, or harnesses as a medical
<|0.00|>on causing damage to DNA.<|2.66|><|2.66|>The means by which we can actually use this, or harnesses as a medical<|6.48|>
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is that different tissues have different sensitivity to that DNA damage. What I show here is a very important slide
<|0.00|>is that different tissues have different sensitivity to that<|3.72|><|3.72|>DNA damage. What I show here is a very important<|7.70|><|7.70|>slide
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features of children syndrome how Sjogren's can impact the autonomic nervous system and then ultimately to review some of the treatment options in folks with Sjogren's
<|0.00|>features of children syndrome how Sjogren's can<|3.68|><|3.68|>impact the autonomic nervous system and<|7.18|><|7.18|>then ultimately to review some of the treatment options in<|11.24|><|11.24|>folks with Sjogren's<|12.32|>
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system in general Sjogren's syndrome can do about anything to the central and peripheral nervous system including autonomic pathways Sjogren's is an under-recognized cause of
<|0.00|>system in general Sjogren's syndrome can do about anything<|3.80|><|3.80|>to the central and peripheral nervous<|8.14|><|8.14|>system including autonomic pathways Sjogren's<|12.10|><|12.10|>is an under-recognized cause of<|15.12|>
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talk SS will refer to Sjogren's syndrome so just so that we're speaking the same language Sjogren's syndrome frequently affects the the autonomic nervous system early to
<|0.00|>talk SS will refer to Sjogren's<|4.06|><|4.06|>syndrome so just so that we're speaking the same language Sjogren's<|8.36|><|8.36|>syndrome frequently affects the the<|12.34|><|12.34|>autonomic nervous system early to<|13.86|>
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system impairment and the manifestations of Sjogren's can range from a person being asymptomatic that is someone with say dry eyes dry mouth and fatigue without any
<|0.00|>system impairment and the manifestations<|4.44|><|4.44|>of Sjogren's can range from a person being asymptomatic<|8.84|><|8.84|>that is someone with say dry eyes<|12.36|><|12.36|>dry mouth and fatigue without any<|14.88|>
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is I wouldn't recommend further testing because it won't change management a ridiculous statement right but that's something that I hear quite frequently I also hear immunotherapy
<|0.00|>is I wouldn't recommend further testing because it<|3.50|><|3.50|>won't change management a ridiculous statement right but that's<|7.12|><|7.12|>something that I hear quite frequently I also hear immunotherapy<|10.88|>
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proven to help these different forms of nervous system impairment and childrens the problem there is if nobody's interested in treating and nobody's treating then how in
<|0.00|>proven to help these different forms of nervous<|3.82|><|3.82|>system impairment and childrens the problem there is<|7.46|><|7.46|>if nobody's interested in treating and nobody's treating then<|11.18|><|11.18|>how in
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but yet have abnormalities on autonomic testing to full-blown autonomic failure where the different autonomic systems are not only dysfunctional but failing really important to
<|0.00|>but yet have abnormalities on autonomic testing to<|3.56|><|3.56|>full-blown autonomic failure where the different autonomic systems<|7.28|><|7.28|>are not only dysfunctional<|10.94|><|10.94|>but failing really important to<|14.20|>
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to argue that there isn't therapeutic nihilism so what this means is that there's a contention that it's impossible to cure or treat people with a particular condition
<|0.00|>to argue that there isn't therapeutic nihilism<|3.86|><|3.86|>so what this means is that there's<|7.58|><|7.58|>a contention that it's impossible to cure or treat<|11.46|><|11.46|>people with a particular condition<|14.00|>
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green I can find the pointer here in green is heart rate so we tilt the person up and we see an excessive rise in heart rate and so this meets criteria for pots we tilt
<|0.00|>green I can find the pointer here in<|3.76|><|3.76|>green is heart rate so we tilt<|7.44|><|7.44|>the person up and we see an excessive rise<|11.36|><|11.36|>in heart rate and so this meets criteria<|14.86|><|14.86|>for pots we tilt<|15.84|>
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again important to make sure that we're speaking the same language so we'll be talking about pots talk about dissident Omiya autonomic neuropathy and gastrointestinal dismal 'ti
<|0.00|>again important to make sure that we're speaking the same language so<|4.22|><|4.22|>we'll be talking about pots talk about dissident Omiya<|7.78|><|7.78|>autonomic neuropathy and gastrointestinal dismal<|11.40|><|11.40|>'ti
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who have an autonomic neuropathy without having pots but it may refer to GI dysmotility where the gastrointestinal system is not emptying in a normal fashion an autonomic neuropathy
<|0.00|>who have an autonomic neuropathy without having pots<|3.64|><|3.64|>but it may refer to GI dysmotility<|7.18|><|7.18|>where the gastrointestinal system is<|10.74|><|10.74|>not emptying in a normal fashion an autonomic<|14.30|><|14.30|>neuropathy<|15.04|>
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pressure so what do we mean by neuropathic pots so neuropathic pots refers to the presence of that abnormal increase in heart rate along with an autonomic neuropathy and this is an
<|0.00|>pressure so what do we mean by neuropathic pots so<|3.88|><|3.88|>neuropathic pots refers to the presence of that abnormal<|8.56|><|8.56|>increase in heart rate along with an autonomic<|12.44|><|12.44|>neuropathy and this is an<|14.78|>
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biologists and you're making more and more intricate disease models. It's important to verify that those models are functionally active and understand how they impact neural
<|0.00|>biologists and you're making more and more intricate disease models.<|3.84|><|3.84|>It's important to verify that those models are functionally<|7.48|><|7.48|>active and understand how they impact neural<|10.34|>
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Thank you all for joining our session today titled Modeling neural activity in a dish: Advancing our understanding of nervous system disorders. My name is Stacie Chvatal and I'm the Product Manager here at Axion Biosystems. We know that all of you are
<|0.00|>Thank you all for joining our session today titled Modeling neural activity<|4.04|><|4.04|>in a dish: Advancing our understanding of nervous system disorders.<|8.10|><|8.10|>My name is Stacie Chvatal and I'm the Product Manager here<|11.80|><|11.80|>at Axion Biosystems. We know that all of you are<|15.12|>
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epileptic drug for it for each individual and often resort to a trial and error approach we can which can have detrimental effects for babies that are in developmentally very sensitive
<|0.00|>epileptic drug for it for each individual and often<|3.54|><|3.54|>resort to a trial and error approach we can which can have detrimental<|7.12|><|7.12|>effects for babies that are in developmentally very sensitive<|10.40|>
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Pediatric epilepsy has extensive genetic diversity with 50 percent of cases caused by the de novo mutations in ion channel genes which of course control neuron excitability.
<|0.00|>Pediatric epilepsy has extensive genetic diversity with<|3.82|><|3.82|>50 percent of cases caused by the de novo mutations<|7.76|><|7.76|>in ion channel genes which of course control neuron excitability.<|12.00|>
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Pediatric epilepsy is a major public health concern. Each year between one to five in every one thousand children born are affected by some sort of seizure. In the most severe cases
<|0.00|>Pediatric epilepsy is a major public health concern.<|2.92|><|2.92|>Each year between one to five in<|6.68|><|6.68|>every one thousand children born are affected<|10.48|><|10.48|>by some sort of seizure. In the most severe cases<|14.20|>
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start seizing within hours or days after they're born. The seizures which result from aberrant electrical activity in the brain are multiform, relentless, and sometimes
<|0.00|>start seizing within hours or days after they're born.<|2.60|><|2.60|>The seizures which result from aberrant electrical activity<|6.44|><|6.44|>in the brain are multiform, relentless, and<|10.06|><|10.06|>sometimes<|10.58|>
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automated wholesale patch instrumentation. This approach relies on the heterologous expression of either the wild type or the mutant KCNQ2 protein in a cell line that stably expresses
<|0.00|>automated wholesale patch instrumentation.<|2.94|><|2.94|>This approach relies on the heterologous expression<|7.00|><|7.00|>of either the wild type or the mutant KCNQ2 protein<|10.72|><|10.72|>in a cell line that stably expresses<|13.24|>
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18 through 64 years I think that's important they assessed the relative vaccine efficacy against cardio
<|0.00|>18 through 64 years I think that's important they<|4.52|><|4.52|>assessed the relative vaccine efficacy against cardio<|8.40|>
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last two weeks that we found interesting or entertaining so on to the literature shall we all right I will be starting off
<|0.00|>last two weeks that we found interesting or entertaining so on<|3.80|><|3.80|>to the literature shall we all right I will be<|7.36|><|7.36|>starting off<|7.96|>
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at microbe.tv the home of our growing multimedia Empire what is your bow tie today Daniel I can't tell so I'm I'm anthrax
<|0.00|>at microbe.tv the home of our growing multimedia Empire<|3.74|><|3.74|>what is your bow tie today Daniel I can't tell<|7.24|><|7.24|>so I'm I'm anthrax<|9.22|>
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adaptation well here the authors conducted a retrospective cohort study using electronic medical records linked to claims data of U.S individuals
<|0.00|>adaptation well here the authors conducted a retrospective<|3.80|><|3.80|>cohort study using electronic medical records<|7.30|><|7.30|>linked to claims data of U.S individuals<|10.38|>
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hospitalizations and against subcategories of this outcome including influence hospitalizations pneumonia hospitalizations myocardial
<|0.00|>hospitalizations and against subcategories of this outcome<|3.60|><|3.60|>including influence hospitalizations pneumonia hospitalizations<|7.60|><|7.60|>myocardial<|8.38|>
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not so great you know we covered this on this week in virology and it's a little concerning right because everyone has this whole idea oh if it was a flu pandemic well that you know we've got vaccines we've got effective drugs
<|0.00|>not so great you know we covered this on this week in virology and<|3.64|><|3.64|>it's a little concerning right because everyone has this whole idea oh if it was<|7.16|><|7.16|>a flu pandemic well that you know we've got vaccines we've got effective<|10.96|><|10.96|>drugs<|11.66|>
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097 so almost like 1.5 million a year 25 of the individuals receive the cell-based vaccine about 75 percent received the egg based vaccine
<|0.00|>097 so almost like 1.5 million<|3.70|><|3.70|>a year 25 of the individuals receive the<|7.36|><|7.36|>cell-based vaccine about 75 percent<|11.08|><|11.08|>received the egg based vaccine<|13.86|>
00:00:00.000
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and ischemic stroke hospitalizations and respiratory hospitalization so big numbers here with a total of 1 million 491
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aged 18 through 64 years of age and uh thinking about flu I this one I kept pretty short and Jama Internal Medicine the article evaluation of
<|0.00|>aged 18 through 64 years of<|3.64|><|3.64|>age and uh thinking about flu I this one<|7.14|><|7.14|>I kept pretty short and Jama Internal Medicine the<|10.80|><|10.80|>article evaluation of<|12.16|>
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antibodies isolated from mice immunized with recombinant vesicular stomatitis virus-based filovirus vaccines both Maps recognize the glycoproteins of
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maybe not um right the article a pan Ebola virus monoclonal antibody cocktail provides protection against Ebola and
<|0.00|>maybe not um right the article<|3.62|><|3.62|>a pan Ebola virus monoclonal antibody cocktail<|7.26|><|7.26|>provides protection against Ebola and<|9.38|>
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out patient children in three low and middle and income countries a multi-centric community-based cohort study was recently published
<|0.00|>out patient children in three low and middle and income<|4.10|><|4.10|>countries a multi-centric community-based cohort study was<|7.96|><|7.96|>recently published<|8.86|>
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protection against Sudan virus challenge in guinea pigs all right I wasn't sure so I was excited about that is that yes but okay
<|0.00|>protection against Sudan virus challenge in guinea<|3.66|><|3.66|>pigs all right I wasn't sure so I was excited about that<|7.24|><|7.24|>is that yes but okay<|8.48|>
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viruses was recently published in jid wishing I was wearing my Ebola bow tie today but here the authors describe two distinct cross-reactive
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762 outpatient consultations in Madagascar Cambodia and Senegal and noted that 29 resulted in the antibiotic prescription and of those
<|0.00|>762 outpatient consultations in Madagascar Cambodia<|4.54|><|4.54|>and Senegal and noted that 29 resulted<|9.08|><|9.08|>in the antibiotic prescription and of those<|12.12|>
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0.1567
fireworks/whisper-v3
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from the idsa so the 2023 guidance on the treatment of antimicrobial resistant gram-negative infections is updated and out and so people are probably
<|0.00|>from the idsa so the 2023 guidance on the treatment<|3.50|><|3.50|>of antimicrobial resistant gram-negative infections<|7.08|><|7.08|>is updated and out and so people<|10.86|><|10.86|>are probably<|11.36|>
00:00:00.000
00:00:13.321
11.511
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row_000287.wav
en
0.1477
fireworks/whisper-v3
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76.5 were associated with diagnoses that did not require an antibiotic the proportion of consultations that involved the diagnosis did require
<|0.00|>76.5 were associated with diagnoses that did<|3.56|><|3.56|>not require an antibiotic the proportion of consultations<|7.12|><|7.12|>that involved the diagnosis did require<|8.90|>
00:00:00.000
00:00:11.440
8.958
[{"word": "76.5", "start": 0.0, "end": 1.47}, {"word": "were", "start": 1.659, "end": 1.743}, {"word": "associated", "start": 1.806, "end": 2.268}, {"word": "with", "start": 2.331, "end": 2.415}, {"word": "diagnoses", "start": 2.499, "end": 3.087}, {"word": "that", "start": 3.192, "end": 3.318}, {"word": "did", "start"...
row_000283.wav
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fireworks/whisper-v3
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Dropped Samples

Samples removed during filtering of None.

These had CER >= 47% against filter model fireworks/whisper-v3, indicating unreliable reference transcriptions.

Columns

Column Description
audio Audio sample
text Original reference transcription
filter_prediction Filter model prediction
filter_cer CER between filter prediction and reference
filter_model Model used for filter CER computation
filter_confidence Geometric mean word confidence (if available)

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