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1589308 | Phospholipid composition and surface-active properties of tracheobronchial secretions from patients with cystic fibrosis and chronic obstructive pulmonary diseases. | Among the various components of tracheobronchial secretions, lipids and particularly phospholipids have been shown to influence rheological properties of airway secretions in patients with cystic fibrosis. We studied the phospholipid composition of tracheobronchial secretions, collected from patients suffering from cys... | [
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"Aged, 80 and over",
"Bronchiectasis",
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"Cystic Fibrosis",
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"Lung Diseases, Obstructive",
"Middle Aged",
"Mucus",
"Phospholipids",
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25510694 | Addition of parity to the risk of malignancy index score in evaluating adnexal masses. | OBJECTIVE: The aim of our study was to evaluate the individual contribution of parity when incorporated as another parameter into the four risk of malignancy indices (RMI 1-4) to differentiate noninvasive benign lesions from invasive malignant ovarian lesions.MATERIALS AND METHODS: After calculating RMI 1-4 for each pa... | [
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11308019 | Cloning and expression of Drosophila melanogaster UDP-GlcNAc:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I. | A TBLASTN search of the Drosophila melanogaster expressed sequence tag (EST) database with the amino acid sequence of human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I, EC 2.4.1.101) as probe yielded a clone (GM01211) with 56% identity over 36 carboxy-terminal amino aci... | [
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"Carbohydrate Sequence",
"Cloning, Molecular",
"Drosophila melanogaster",
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"Molecular Sequence Data",
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15135636 | Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. | The pKZ1 recombination mutagenesis model has provided a sensitive assay where we study somatic intrachromosomal recombination (SICR) as a mutation end-point. SICR is associated with non-homologous end-joining repair of double-strand breaks and can result in chromosomal inversions and deletions, both of which are common... | [
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2861630 | Broxaterol: a double-blind clinical trial comparing broxaterol and salbutamol. | 10 patients with reversible bronchospasm received by the oral route in a double-blind fashion broxaterol, Z. 1170, 0.250 and 0.500 mg in comparison with salbutamol 4 mg as base and a placebo. Measurements of FEV1, heart rate and arterial pressure were performed before and 0.5, 1, 2, 4, 6 h after each treatment. Z. 1170... | [
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19798462 | Validation and application of a method for the determination of total chromium in rat tissues by inductively coupled plasma mass spectrometry. | The validation of a method for the determination of chromium (Cr) in F-344/N rat tissues by inductively coupled plasma-mass spectrometry is described. Samples were analyzed after a rapid, open-vessel microwave digestion procedure. Performance of the method was evaluated using kidney tissue across a concentration range ... | [
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2808128 | The perversions in analysis. | The perversions are initially defined as sexual behaviours which in our culture are generally regarded as corrupt, fearful, and forbidden. The effect of this attitude upon the way they are handled in analysis is considered, and the work of the late German psychoanalyst, Fritz Morgenthaler, is cited as presenting a way ... | [
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9096784 | Scanning electron microscopic evaluation of the skin surface after ultrasound exposure. | BACKGROUND: Transdermal drug-delivery systems have become widely accepted clinically for the administration of several systemic drugs. Recently, research on ultrasound irradiation to facilitate the penetration of drugs through the skin have been reported. The present study investigated the morphological changes induced... | [
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9367004 | Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage. | Recent studies demonstrated the role of antioxidants in preventing organ damage caused by free radicals. The present study was conducted to find out the modulatory effect of some antioxidants on lipid patterns in experimentally-induced liver damage. Rats chronically intoxicated with carbon tetrachloride (CCl4) were use... | [
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30720960 | [Clinical value of multiplex immune assay of antinuclear antibodies in systemic lupus erythematosus.] | A promising trend in the diagnosis of systemic autoimmune diseases is the multiplex immune assay (MIA) of autoantibodies and other laboratory biomarkers using microchips. The aim of the work was to study the diagnostic and prognostic significance of MIA antinuclear antibody (ANA) profiles in systemic lupus erythematosu... | [
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16856595 | Cell structure of barb ridges in down feathers and juvenile wing feathers of the developing chick embryo: barb ridge modification in relation to feather evolution. | The present study deals with the cell structure and three-dimensional organization of barb and barbule cells within barb ridges of down feathers and juvenile feathers in the chick embryo. Juvenile feathers represent the second generation of feathers in the wing, and replace down feathers some weeks after hatching. With... | [
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25972896 | Classification of Two Class Motor Imagery Tasks Using Hybrid GA-PSO Based K-Means Clustering. | Transferring the brain computer interface (BCI) from laboratory condition to meet the real world application needs BCI to be applied asynchronously without any time constraint. High level of dynamism in the electroencephalogram (EEG) signal reasons us to look toward evolutionary algorithm (EA). Motivated by these two f... | [
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24917057 | Uncalibrated continuous cardiac output measurement in liver transplant patients: LiDCOrapid™ system versus pulmonary artery catheter. | OBJECTIVE: The aim of the study was to assess the level of agreement between continuous cardiac output estimated by uncalibrated pulse-power analysis (PulseCOLiR) and intermittent (ICO) and continuous cardiac output (CCO) obtained using a pulmonary artery catheter (PAC).DESIGN: Prospective cohort study.SETTING: Univers... | [
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21968021 | Osteopontin and endostatin concentrations in peripheral blood of patients with adrenal tumors undergoing unilateral adrenalectomy. | Peripheral blood osteopontin (OPN) and endostatin (END) levels were studied in 35 patients with adrenal cortex tumors and 10 patients with pheochromocytoma before unilateral adrenalectomy, as well as in 10 healthy subjects (controls). Thirty days after surgery, OPN and END were evaluated again in 16 patients with adren... | [
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8517866 | The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine. | The effects of 1,2-dichlorovinyl-cysteine (DCVC) on the intracellular free calcium concentration ([Ca2+]i) and the mitochondrial membrane potential (delta phi) were investigated in freshly isolated rat kidney proximal tubular cells (PTC). Prior to cell death, DCVC induced a rise in [Ca2+]i and a decrease in the delta p... | [
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15130049 | Modeling event times with multiple outcomes using the Wiener process with drift. | Length of stay in hospital (LOS) is a widely used outcome measure in Health Services research, often acting as a surrogate for resource consumption or as a measure of efficiency. The distribution of LOS is typically highly skewed, with a few large observations. An interesting feature is the presence of multiple outcome... | [
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624899 | The permeability of the skin of the aquatic anuran Xenopus laevis (Pipidae). | The undirectional transcutaneous fluxes of Na, Cl, water and urea were measured, in vitro, in the pipoid anuran Xenopus laevis. An active uptake (outside to inside) of Na was observed but Cl movements appeared to be passive. The effluxes of Na and Cl were low compared to those measured in other species of amphibians. T... | [
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8596692 | Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton. | The role of the cytoskeleton in the rundown and reactivation of adenosine triphosphate (ATP) sensitive K+ channels (KATP channels) was examined by perturbing selectively the intracellular surface of inside-out membrane patches excised from guinea-pig ventricular myocytes. Actin filament-depolymerizing agents (cytochala... | [
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24664976 | Local area cartilage segmentation: a semiautomated novel method of measuring cartilage loss in knee osteoarthritis. | OBJECTIVE: To assess the responsiveness and reader time of a novel semiautomated tool to detect knee cartilage loss over 2 years in subjects with knee osteoarthritis.METHODS: A total of 122 subjects from the Osteoarthritis Initiative progression cohort were selected. A reader used the software method to segment cartila... | [
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17997050 | Barriers associated with the treatment of hepatitis C virus infection among illicit drug users. | BACKGROUND: Illicit drug users account for the majority of cases of HCV infection in the developed world, but few have received treatment.METHODS: We evaluated barriers to initiating HCV treatment -- including general treatment willingness -- and factors associated with these among HCV infected illicit drug users. Part... | [
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15849543 | Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients. | BACKGROUND: Chronic kidney disease patients have a high prevalence of inflammation and oxidative stress, and this has been associated with the excess cardiovascular morbidity and mortality observed in this population. Because maintenance hemodialysis is ineffective in controlling these factors, we hypothesized that res... | [
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970661 | Liver hepatocyte mitotic activity after a single injection of phenobarbital in immature male rats. | In contrast to multiple injections of phenobarbital, a single injection of 50 mg/kg body wt of phenobarbital into immature male rats results, after a transient increase in hepatocyte mitotic activity, in a marked decrease in hepatocyte mitotic activity to below control levels by day 3, followed by a return to control l... | [
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18835038 | Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia. | Tyrosine kinase inhibitors (TKIs) directed against the Bcr-Abl kinase have revolutionized the treatment of chronic myelogenous leukemia (CML). Relatively little is known regarding the effects of these agents on the kidney. Clinically, there have been a handful of reports associating imatinib with acute renal failure. P... | [
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18953511 | Beta-D-xylosidase from Selenomonas ruminantium: thermodynamics of enzyme-catalyzed and noncatalyzed reactions. | Beta-D-Xylosidase/alpha-L-arabinofuranosidase from Selenomonas ruminantium is the most active enzyme known for catalyzing hydrolysis of 1,4-beta-D: -xylooligosaccharides to D-xylose. Temperature dependence for hydrolysis of 4-nitrophenyl-beta-D-xylopyranoside (4NPX), 4-nitrophenyl-alpha-L-arabinofuranoside (4NPA), and ... | [
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6409673 | Action of tamoxifen on folliculogenesis in the menstrual cycle of infertile patients. | Daily estimations of follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, and progesterone were made in the serum of eight infertile patients from day 1 through the follicular phase during menstrual cycles before and after tamoxifen therapy. Tamoxifen therapy was found to shorten the follicular phas... | [
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22624309 | Can rare positive interactions become common when large carnivores consume livestock? | Livestock populations in protected areas are viewed negatively because of their interaction with native ungulates through direct competition for food resources. However, livestock and native prey can also interact indirectly through their shared predator. Indirect interactions between two prey species occur when one pr... | [
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24852500 | Association between intraoperative electroencephalographic suppression and postoperative mortality. | BACKGROUND: Low bispectral index values frequently reflect EEG suppression and have been associated with postoperative mortality. This study investigated whether intraoperative EEG suppression was an independent predictor of 90 day postoperative mortality and explored risk factors for EEG suppression.METHODS: This obse... | [
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11990002 | Nutritional and metabolic consequences of the early Maillard reaction of heat treated milk in the pig. Significance for man. | BACKGROUND: During the processing of foods, the Maillard reaction may occur contributing to altering the nutritional value of proteins. In dairy products the formation of lactuloselysine reduces the availability of lysine but the effects on the other nutrients are not very well known.AIM OF THE STUDY: Determination of ... | [
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3628679 | Evaluation of therapeutic outcome: some reflections on methodology. | Problems connected with choice of outcome-criteria are discussed. Some results from an outcome study of student-conducted dynamic psychotherapies are presented. The discussion is focused on discrepancies between subjective data and more objective measures, as reflected in Rorschach test results. It is claimed that in o... | [
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22929853 | Late presentations of congenital diaphragmatic hernia. | The occurrence of congenital diaphragmatic hernia in adults is rare and misleading even to experienced clinicians. In contrast to neonatal diaphragmatic hernias, most of the adult patients present with vague gastrointestinal and respiratory symptoms mimicking other diseases. Hence high index of suspicion is required. W... | [
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"Hernias, Diaphragmatic, Congenital",
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"Male",
"Radiography"
] | {
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16382948 | Relationship between mercury accumulation in young-of-the-year yellow perch and water-level fluctuations. | A three-year (2001-2003) monitoring effort of 14 northeastern Minnesota lakes was conducted to document relationships between water-level fluctuations and mercury bioaccumulation in young-of-the-year (YOY) yellow perch (Perca flavescens) collected in the fall of each year at fixed locations. Six of those lakes are loca... | [
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22999287 | Short communication: Characterization of Shiga toxin 2-carrying bacteriophages induced from Shiga-toxigenic Escherichia coli isolated from Italian dairy products. | Forty samples of raw milk cheese and 25 samples of raw milk itself were subjected to enrichment culture for Shiga-toxigenic Escherichia coli (STEC), and a single Shiga toxin 2- (Stx(2)) positive strain was obtained from one of the cheese samples. Thus, aged cheeses in which the curd is subsequently heat treated (48°C) ... | [
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"Milk",
"Molecular Sequence Data",
"Podoviridae",
"Shiga Toxin 2",
"Shiga-Toxigenic Escherichia coli"
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10759767 | Effects of anti-rheumatic gold salts on NF-kappa B mobilization and tumour necrosis factor-alpha (TNF-alpha)-induced neutrophil-dependent cytotoxicity for human endothelial cells. | We have previously shown that the gold-containing disease-modifying anti-rheumatic drugs, auranofin (AF) and gold sodium aurothiomalate (GSTM) reduce human umbilical vein endothelial cell (HUVEC) adhesion molecule expression and neutrophil (PMN) adherence. AF diminishes E-selectin and intercellular adhesion molecule-1 ... | [
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898456 | Testicular torsion in adults: plea for its consideration early in clinical evaluation of acute scrotum. | A case of a thirty-eight-year-old man with acute scrotum is presented. Past history of transient episodes of testicular pain, negative findings on urinalysis, and lack of symptomatic relief despite antibiotic therapy plus a high index of suspicion helped establish the correct diagnosis of testicular torsion. A long del... | [
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20820904 | PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. | Diabetes mellitus is a multifactorial metabolic disease, caused by the complete or relative absence of insulin hormone, which results in the deterioration of carbohydrate, protein, and lipid metabolism. The PON1 55 and 192 polymorphisms have been reported to be associated with type 2 diabetes and its complications. In ... | [
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26272639 | Determine the structure of phosphorylated modification of icariin and its antiviral activity against duck hepatitis virus A. | BACKGROUND: Our previous research showed that icariin (1) and its phosphorylated structural modification (2) improved the survival and attenuated oxidative stress and liver dysfunction induced by duck virus hepatitis. In this paper, we were one step closer to determine the structure of phosphorylation icariin (2) by th... | [
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26931180 | Evidence-based and unlicensed indications for proton pump inhibitors and patients' preferences for discontinuation: a pilot study in a sample of Italian community pharmacies. | WHAT IS KNOWN AND OBJECTIVE: Despite the widespread use of proton pump inhibitors (PPIs), little is known about the appropriateness of treatment according to the indications reported by patients and their involvement in the process of treatment discontinuation. In patients who are unlikely to benefit, the medication sh... | [
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3554066 | The role of antepartum testing in the management of postterm pregnancies with heavy meconium in early labor. | The documented association between heavy meconium in early labor and increased perinatal morbidity and mortality has alerted physicians to the presence of a potential high-risk fetal condition and to the possible need for immediate fetal blood pH determination. The purpose of this study was to determine whether antepar... | [
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30826490 | Risk of attempted suicide among adolescents and young adults with traumatic brain injury: A nationwide longitudinal study. | BACKGROUND: Traumatic brain injury (TBI) and suicidal behavior lead to serious morbidity and premature mortality. TBI in adulthood is associated with a higher incidence of suicide, but the risk in adolescents and young adults is not clear.METHODS: Longitudinal follow-up data were extracted from a National Health Insura... | [
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12028157 | Rhabdomyomatous mesenchymal hamartoma: an unusual dermal entity with a report of two cases and a review of the literature. | BACKGROUND: Rhabdomyomatous mesenchymal hamartoma (RMH) is a rare congenital lesion of the dermis and soft tissues consisting of a disordered and varied collection of mature adipose tissue, skeletal muscle, adnexal elements and nerve bundles. This entity exists under various names including striated muscle hamartoma, c... | [
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] | {
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} |
30941791 | The cingulum and cingulate U-fibers in children and adolescents with autism spectrum disorders. | The cingulum is the major fiber system connecting the cingulate and surrounding medial cortex and medial temporal lobe internally and with other brain areas. It is important for social and emotional functions related to core symptomatology in autism spectrum disorders (ASDs). While the cingulum has been examined in aut... | [
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] | {
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32530394 | Characterization of Ba813 | Introduction. Bacillus cereus harbouring Ba813, a specific chromosomal marker of Bacillus anthtacis, is found in patients with severe manifestations and causes nosocomial outbreaks.Aim. We assessed the genetic characteristics and virulence of Ba813(+) B. cereus in a hospital setting.Methodology. Three neutropenic patie... | [
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"Bacillus anthracis",
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31148108 | In Vitro Measurement of H2 | Isolated tissue chamber bath system and wire myograph were developed for "in vitro" investigation of vasoactive responses on isolated arteries from a variety of animal species and vascular beds. The chapter characterizes the main principles of mechanical measurement of the changes in isometric tension of vascular smoot... | [
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"Rats, Wistar",
"Vasodilation"
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15304102 | Development of UV-induced squamous cell carcinomas is suppressed in the absence of SPARC. | SPARC (Secreted Protein Acidic and Rich in Cysteine) is a multifunctional glycoprotein belonging to a group of matrix-associated factors that mediate cell-extracellular matrix interactions but have no structural roles. In the present study we investigated the contribution of SPARC to factors that influence the developm... | [
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31347312 | Implementing Competency-Based Medical Education in Internal Medicine Residency Training Program: the Process and Impact on Residents' Satisfaction. | BACKGROUND: Graduate medical education is shifting from the traditional apprenticeship model to a competency-driven model. Here we describe the design and implementation of competency-based medical education (CBME) in an internal medicine residency program, and report satisfaction survey results.METHODS: We redesigned ... | [
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2320395 | Stroke volume and left ventricular output in preterm infants with patent ductus arteriosus. | To assess the effect of patent ductus arteriosus (PDA) on left ventricular output (LVO) we studied stroke volume (SV), LVO, and heart rate (HR) in 21 very low birth wt preterm neonates with clinically symptomatic PDA before and after surgical ligation. Six additional infants were also studied before PDA with left-to-ri... | [
4171,
13231,
6763,
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229,
1485,
10795,
1239
] | [
"Cardiac Output",
"Ductus Arteriosus, Patent",
"Echocardiography, Doppler",
"Humans",
"Infant, Newborn",
"Infant, Premature",
"Respiratory Distress Syndrome, Newborn",
"Stroke Volume"
] | {
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} |
20618268 | Household smoking behaviours and exposure to environmental tobacco smoke among infants: are current strategies effectively protecting our young? | OBJECTIVE: To determine the prevalence of infant exposure to environmental tobacco smoke (ETS) among infants attending child health clinics in regional NSW; the association between such exposure and household smoking behaviours; and the factors associated with smoking restrictions in households with infants.METHODS: Pa... | [
204,
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21806469 | The antinociceptive effect of the asthma drug ibudilast in rat models of peripheral and central neuropathic pain. | Ibudilast, an asthma drug, has demonstrated antinociceptive effects in several rat models of peripheral neuropathic pain, and a proposed mechanism of action is the inhibition of release of the cytokine tumor necrosis factor-á (TNF-á) from activated spinal microglia. Spinal glial activation has also been demonstrated in... | [
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26092551 | Contrast pooling in videofluoroscopic swallowing study as a risk factor for pneumonia in children with dysphagia. | OBJECTIVE: To determine if laryngeal contrast pooling on a videofluoroscopic swallowing study increases the risk for pneumonia in the following 6 months in children with dysphagia. Secondarily, to determine in the same population, if laryngeal abnormalities or syndromic disorders increase the risk for pneumonia in the ... | [
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18666924 | Preterm delivery risk in migrants in Italy: an observational prospective study. | BACKGROUND: Various studies have ascertained different birth outcomes between resident and migrant populations in western countries. Considering preterm delivery (<37 complete weeks of gestation) as a perinatal risk condition, we assessed its rate in migrant and native Italian women who delivered in the main public hos... | [
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2523696 | Fifteen-year results of coronary artery bypass for isolated left anterior descending coronary artery disease. | During 1971 through 1975, 266 patients underwent primary coronary artery bypass grafting for occlusive disease confined to the left anterior descending coronary artery. Actuarial survival at 15 years was 72.7% with 60% of survivors being free from angina. Although the cause of death was cardiac related in 50% of the pa... | [
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32454417 | Induction chemotherapy followed by cisplatin or cetuximab concomitant to radiotherapy for laryngeal/hypopharyngeal cancer: Long-term results of the TREMPLIN randomised GORTEC trial. | BACKGROUND: In Europe, induction chemotherapy (ICT) followed by radiotherapy is preferred to conventional chemoradiotherapy to avoid total laryngectomy in patients with laryngeal/hypopharyngeal cancer. In comparison with conventional radiotherapy, bioradiotherapy with cetuximab significantly improves locoregional contr... | [
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25170959 | Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats. | Inflammation is a hallmark of several disease states ranging from neurodegeneration to sepsis but is also implicated in physiological processes like ageing. Non-resolving inflammation and prolonged neuroinflammation are unclear processes implicated in several conditions, including ageing. In this study we studied the l... | [
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27522090 | Beauty is in the belief of the beholder: cognitive influences on the neural response to facial attractiveness. | Judgments of facial attractiveness are central to decision-making in various domains, but little is known about the extent to which they are malleable. In this study, we used EEG/ERP methods to examine two novel influences on neural and subjective responses to facial attractiveness: an observer's expectation and repeti... | [
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23171123 | Entomological indices of malaria transmission in Chikhwawa district, Southern Malawi. | BACKGROUND: Although malaria is highly prevalent throughout Malawi, little is known of its transmission dynamics. This paper describes the seasonal activity of the different vectors, human biting indices, sporozoite rates and the entomological inoculation rate in a low-lying rural area in southern Malawi.METHODS: Vecto... | [
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22052654 | Antioxidant effect of propolis against exposure to chromium in Cyprinus carpio. | The aim of the present study was to investigate the ameliorative properties of propolis against the toxic effects of chromium (VI) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defence system components in carp (Cyprinus carpio). The fish were exposed to sublethal concentrations o... | [
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30021506 | How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial. | BACKGROUND: Depression in older people may have a prevalence as high as 20%, and is associated with physical co-morbidities, loss, and loneliness. It is associated with poorer health outcomes and reduced quality of life, and is under-diagnosed and under-treated. Older people may find it difficult to speak to their GPs ... | [
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7983018 | Molecular structure of redox metal centers of the cytochrome bo complex from Escherichia coli. Spectroscopic characterizations of the subunit I histidine mutant oxidases. | A site-directed mutagenesis study on the conserved subunit I histidines of the cytochrome bo complex in Escherichia coli identified ligands of the low spin heme B and CuB centers; however, the assignment of the proximal ligand of the high spin heme O was ambiguous (Minagawa, J., Mogi, T., Gennis, R. B., and Anraku, Y. ... | [
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9529265 | Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. | BACKGROUND: We compared cardiac mast cell (HHMC) density and the immunological and nonimmunological release of mediators from mast cells isolated from heart tissue of patients with idiopathic dilated (DCM) (n=24) and ischemic cardiomyopathy (ICM) (n = 10) undergoing heart transplantation and from control subjects (n = ... | [
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2687269 | Purification of a DNA replication terminus (ter) site-binding protein in Escherichia coli and identification of the structural gene. | In Escherichia coli cells, there is a protein that specifically binds to DNA replication terminus (ter) sites on the host and plasmid genome and then blocks progress of the DNA replication fork. We reported that extract of the cells carrying the plasmid with the tau gene, which was identified to be an essential gene fo... | [
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21293056 | A poly(å-caprolactone) device for sustained release of an anti-glaucoma drug. | Implantable dorzolamide-loaded discs were prepared by blending poly(å-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL... | [
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21859373 | Rapid access to ketones related to oleanolic and ursolic acids. | We describe in this article a process with which to obtain different ketones related to oleanolic and ursolic acids from a natural source, Salvia canariensis L., with minimal use of chromatography columns. Amongst the isolated compounds was 12á-bromo-3-oxo-olean-13, 28-olide (3), which was fully characterised, includin... | [
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2953308 | Stromal serine protein kinase activity in spinach chloroplasts. | At least twelve 32P-labeled stromal proteins were detected by electrophoresis under denaturing conditions when intact chloroplasts were incubated with 32Pi, in the light but only three were detected in the presence of 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU) or in the dark. Incubation of isolated stroma with [gam... | [
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11312059 | Nitric oxide synthase neurons in the rodent spinal cord: distribution, relation to Substance P fibers, and effects of dorsal rhizotomy. | The indirect immunofluorescent method was employed to investigate the distribution of neuronal nitric oxide synthase-like immunoreactivity(nNOS-LI) in the spinal cord of the golden hamster and to compare it to data obtained from rats. Immunoreactive neurons were found throughout the cervico-sacral extent in the dorsal ... | [
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27649390 | Immunopathological characterization of cryptoglandular anal fistula: a pilot study investigating its pathogenesis. | AIM: The pathogenesis of cryptoglandular anal fistula (AF) is still under debate. Tissue inflammation could play a primary role. The pathological process of epithelial mesenchymal transition (EMT) might be involved but has never been investigated.METHOD: In a prospective pilot study, 12 patients with an AF had a fistul... | [
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6534843 | [The antisera avidity]. | In a LN-equivalence point titration system the modulation of immune complex formation of high avide antisera by specific and unspecific factors is measurable. Protamine-Cl is a potent enhancer of complex formation. | [
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1867758 | The acquisition of self-stimulation of the medical prefrontal cortex following exposure to escapable or inescapable footshock. | The effect of acute stress on the acquisition of an instrumental action reinforced by electrical stimulation of the medial prefrontal cortex (MPC) was investigated by exposing rats to either escapable, inescapable or no footshock prior to daily self-stimulation training sessions. Treatment with inescapable footshock di... | [
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29364394 | Arquivos de Neuro-Psiquiatria: 75 years. | This year marks the 75th year of publication of Arquivos de Neuro-Psiquiatria (ANP), the official journal of the Brazilian Academy of Neurology and one of the most important neuroscience journals in Latin America. ANP was initially edited by Oswaldo Lange, its founder, and subsequently by Antonio Spina-Fran?a Netto and... | [
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27332955 | Right ventricle dimensions and function in response to acute hypoxia in healthy human subjects. | AIM: Acute hypoxia produces acute vasoconstriction in the pulmonary circulation with consequences on right ventricular (RV) structure and function. Previous investigations in healthy humans have been restricted to measurements after altitude acclimatization or were interrupted by normoxia. We hypothesized that immediat... | [
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4084215 | Biochemistry and genetics of esterase-20 (ES-20), a second trimeric carboxylesterase of the house mouse (Mus musculus). I. Purification and characterization of ES-20C1 from male kidney. | ES-20 was isolated from male mouse kidney and purified 350-fold by ion-exchange chromatography, isoelectric focusing, and gel filtration. The resultant product was apparently homogeneous by the criteria of polyacrylamide gel electrophoresis and immunodiffusion and represented a major fraction of male mouse kidney ester... | [
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11042264 | Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation. | The X gene product of the human hepatitis B virus (HBx), a major factor responsible for hepatitis and hepatocellular carcinoma, modulates transactivation by a variety of transcription factors. Herein, expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene was found to be regulated transcriptionally by HBx thr... | [
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31093648 | Evolution of Insect Iridescence: Origins of Three-Dimensional Photonic Crystals in Weevils (Coleoptera: Curculionoidea). | A variety of photonic mechanisms give rise to iridescence and other structural colors in insects. In weevils (Coleoptera: Curculionoidea), iridescence is created by the most complex of these mechanisms, the three-dimensional photonic crystal. These self-assembling crystals take the form of triply periodic networks with... | [
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22500292 | Use of a potentiometric vital dye to determine the effect of the herbicide bromoxynil octanoate on mitochondrial bioenenergetics in Chlamydomonas reinhardtii. | BACKGROUND: The aims of the present study were to validate a vital mitochondrial potentiometric staining method in Chlamydomonas reinhardtii and to utilise this method to examine the effect of the herbicide bromoxynil octanoate on mitochondrial potential in this species. A range of stains was investigated, including Rh... | [
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26520121 | Three-dimensional Mammary Epithelial Cell Morphogenesis Model for Analysis of TGF? Signaling. | Culturing mammary epithelial cells in laminin-rich extracellular matrices (three dimensional or 3D culture) offers significant advantages over that in the conventional two-dimensional (2D) tissue culture system in that it takes into considetation the impact of extracellular matrix (ECM) microenvironment on the prolifer... | [
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27717109 | Follicular development and morphological changes in the vaginal epithelium during the estrous cycle of Galea spixii. | The current study aimed to determine if characteristics observed in vaginal cytology during the estrous cycle of female SYT cavies corresponded with proliferation of the vaginal epithelium, characterized by proliferating cell nuclear antigen (PCNA) immunolocalization, and with follicular development at different phases... | [
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15986442 | Survivin expression by metastatic melanoma predicts poor disease outcome in patients receiving adjuvant polyvalent vaccine. | Survivin and livin are members of the inhibitor of apoptosis protein (IAP) family. We hypothesized that elevated expression levels of these 2 IAP genes in resected advanced-stage metastatic melanoma lesions would be associated with poor disease outcome in patients receiving a polyvalent therapeutic cancer vaccine (Canv... | [
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21400916 | [Survey of severe contact lens-associated microbial keratitis in Japan]. | PURPOSE: To understand the current state of severe contact lens (CL)-associated microbial keratitis in Japan.METHOD: The survey was conducted by the Japan Contact Lens Society and the Japanese Association for Ocular Infection in 224 facilities from April 2007 to March 2009. Patients who were diagnosed with CL-associate... | [
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22900372 | Mutation analysis in spinal muscular atrophy using allele-specific polymerase chain reaction. | Polymerase chain reaction (PCR), followed by restriction digestion is universally used for molecular diagnosis of spinal muscular atrophy (SMA). In the present study, we have used a modified strategy based on amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) to develop a rapid and reliable m... | [
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19703974 | Mouse eosinophils possess potent antibacterial properties in vivo. | Eosinophils are best known as the predominant cellular infiltrate associated with asthma and parasitic infections. Recently, numerous studies have documented the presence of Toll-like receptors (TLRs) on the surfaces of eosinophils, suggesting that these leukocytes may participate in the recognition and killing of viru... | [
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17083859 | A case of factitious subcutaneous emphysema. | A 13-year-old girl presented with a 2-month history of recurrent soft tissue swelling of her right upper extremity. Dermatological examination revealed soft tissue crepitation and a small ulcer on the dorsum of her right hand. After several investigations including radiographic and systemic blood tests the diagnosis of... | [
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22089320 | Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behavior. | Drug abstinence is frequently compromised when addicted individuals are re-exposed to environmental stimuli previously associated with drug use. Research with human addicts and in animal models has demonstrated that extinction learning (non-reinforced cue-exposure) can reduce the capacity of such stimuli to induce rela... | [
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23011625 | Prospective evaluation of Doppler sonography to detect the twinkling artifact versus unenhanced computed tomography for identifying urinary tract calculi. | OBJECTIVES: The twinkling artifact is an emerging tool for identifying urinary tract calculi. The purpose of this prospective study was to evaluate the diagnostic accuracy of the twinkling artifact compared to unenhanced computed tomography in detecting urolithasis.METHODS: After Research Ethics Board approval, 51 pati... | [
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6688589 | Cell surface glycoproteins of 13762NF mammary adenocarcinoma clones of differing metastatic potentials. | Rat 13762NF mammary adenocarcinoma cell surface glycoproteins from s.c. tumor- or lung metastases-derived cell clones of differing spontaneous metastatic potentials were examined for their relationship to metastasis. After treatment with neuraminidase, lectin-binding assays showed that highly metastatic clone MTLn3 cel... | [
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434059 | Opticociliary veins in a primary optic nerve sheath meningioma. | A 59-year-old man developed painless visual loss in his left eye over a one-year period, with rapid progression to blindness over three months. Ocular examination of the left eye revealed proptosis, marked optic disk pallor, dilated retinal veins, and congeries of vessels at the disk margin (opticociliary veins). His r... | [
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2231147 | Squamous cell carcinoma-antigen for detection of squamous cell and mucoepidermoid carcinoma after primary treatment: a preliminary report. | This study evaluated the efficacy of using the periodic measurement of the serum level of squamous cell carcinoma antigen (SCC-antigen) for determining the local recurrence and/or metastasis of squamous cell and mucoepidermoid carcinomas after primary treatment. It was found that at the time of clinical recognition of ... | [
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1688788 | Neonatal auditory brain-stem response threshold and latency: 1 hour to 5 months. | Auditory brain-stem evoked responses were recorded in normal neonates and infants ranging in age from less than 1 h to 5.5 months. The average threshold in neonates 0-5 h old was 29 dB greater than that in adults, reaching the adult threshold range within 2 weeks. The latency of wave I in 0-5 h neonates was 1.81 msec a... | [
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16601301 | Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women. | The purpose of this study was to investigate mRNA expression of several key skeletal muscle myogenic controllers; myogenic differentiation factor (MyoD), muscle regulatory factor 4 (MRF4), myogenic factor 5 (Myf5), myogenin, myostatin, and myocyte enhancer factor 2 (MEF2) at rest and 4 h after a single bout of resistan... | [
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27984094 | Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites. | The goal of the present work was to characterise the effects of selegiline on the rat sleep pattern. Furthermore, for comparative purposes, the pharmacokinetics of selegiline and its metabolites in brain and plasma were investigated, and microdialysis experiments were performed to examine the resulting effect on dopami... | [
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19359686 | Effects of time-specific F-strain Mycoplasma gallisepticum inoculation overlays on prelay ts-11-strain M. gallisepticum vaccination on digestive and reproductive organ characteristics of commercial egg-laying hens. | Two trials were conducted to determine the effects of a prelay ts-11-strain Mycoplasma gallisepticum (ts-11MG) vaccination alone or in conjunction with F-strain M. gallisepticum (FMG) inoculation overlays at 2 different age periods during lay on the digestive and reproductive organ characteristics of commercial egg-lay... | [
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998102 | [Pathogenesis of central mechanisms of speech function disorders in children with alalia]. | A study of special synchronization of brain biopotentials in EEG registrations by a correlational analysis permitted to establish that in children with alalia there was a complex defect in intercentral relations of the associative infraparietal areas with auditory, visual and motor analyzers in the left hemisphere. In ... | [
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13976
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24530852 | Thermal decomposition of ammonium perchlorate in the presence of Al(OH)(3)·Cr(OH)(3) nanoparticles. | An Al(OH)(3)·Cr(OH)(3) nanoparticle preparation procedure and its catalytic effect and mechanism on thermal decomposition of ammonium perchlorate (AP) were investigated using transmission electron microscopy (TEM), X-ray diffraction (XRD), thermogravimetric analysis and differential scanning calorimetry (TG-DSC), X-ray... | [
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25450099 | A phylogenomic analysis of turtles. | Molecular analyses of turtle relationships have overturned prevailing morphological hypotheses and prompted the development of a new taxonomy. Here we provide the first genome-scale analysis of turtle phylogeny. We sequenced 2381 ultraconserved element (UCE) loci representing a total of 1,718,154bp of aligned sequence.... | [
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17341123 | Synergetic effects of nanoporous support and urea on enzyme activity. | We report synergetic effects of functionalized mesoporous silica (FMS) and urea to promote favorable protein conformational changes. The specific activity of glucose isomerase (GI) entrapped in FMS in the presence of urea was approximately double that of GI in solution in the absence of urea. Rather than losing all act... | [
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"Particle Size",
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23956270 | Arterial grafts do not counteract target vessel occlusion. | OBJECTIVES: Grafted, non-occluded coronary arteries might contribute substantially to the myocardial blood supply and serve as a basis for vascular collateralization which preserves the myocardium in the event of graft occlusion. Early studies indicated that grafting with saphenous vein, but not internal mammary arteri... | [
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"Coronary Artery Bypass",
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"Female",
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9745220 | [A familial outbreak of verotoxin-producing Escherichia coli O103:H2 infection in which a calf was the suspected infectious source]. | A familial outbreak of Verotoxin-producing Escherichia coli (VTEC) infection occurred in July 1996 in AKITA prefecture. Four VTEC strains harboring VT-1 and eaeA genes were isolated from three patients and a calf, breeding farm for which was located as close as 4 meters from the house where the patients lived in. All o... | [
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"Child, Preschool",
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"Escherichia coli",
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12056651 | Histochemical and biochemical studies on the secretory mechanisms of some glands of guinea-pigs treated with histamine. | The experiments were carried out on 60 mature male guinea-pigs, randomly allocated into six groups. Animals from Group I (control) received intracardiac injections of 0.25 cm3 0.9% NaCl, while animals from all other groups received intracardiac injections of histamine after the intraperitoneal application of H1, H2 and... | [
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"Endocrine Glands",
"Exocrine Glands",
"Guinea Pigs",
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"Histamine H1 Antagonists",
"Histamine H2 Antagonists",
"Ipratropium",
"Male",
"Muscarinic Antagonists",
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"Pyrilamine",
"Ranitidine",
"Thyroid Gland",
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7523253 | Identification of a ToxR-activated gene, tagE, that lies within the accessory colonization factor gene cluster of Vibrio cholerae O395. | The nucleotide (nt) sequence has been determined for a Vibrio cholerae ToxR-activated gene designated tagE that is located within a cluster of genes required for efficient intestinal colonization. The tagE gene encompasses 909 nt and is predicted to encode a 303-amino-acid (aa) protein with an estimated molecular mass ... | [
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20609270 | Cognitive test performance predicts change in functional status at the population level: the MYHAT Project. | In the community at large, many older adults with minimal cognitive and functional impairment remain stable or improve over time, unlike patients in clinical research settings, who typically progress to dementia. Within a prospective population-based study, we identified neuropsychological tests predicting improvement ... | [
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27525889 | Cloning and characterization of the UBC gene from lotus (Nelumbo nucifera). | Protein ubiquitination is extensively involved in the regulation of a considerable number of physiological processes in plant cells. E2 (ubiquitin-conjugating enzyme, UBC), one of the essential enzymes of eukaryotic ubiquitination, catalyzes protein ubiquitination together with E1 and E3. In this study, we cloned four ... | [
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439,
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"Arabidopsis",
"Base Sequence",
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"Gene Expression",
"Nelumbo",
"Phylogeny",
"Plant Proteins",
"Sequence Homology, Amino Acid",
"Stress, Physiological",
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18989771 | Synergistic effect of bisphosphonate and docetaxel on the growth of bone metastasis in an animal model of established metastatic bone disease. | Bisphosphonates decrease bone resorption and reduce significantly the rate of skeletal complications in patients with metastatic bone disease. Bisphosphonates have also been shown to exhibit antitumor activity in vitro but in vivo results have been equivocal. In the present study, we investigated the effects of bisphos... | [
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"Bone Density Conservation Agents",
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"Docetaxel",
"Drug Synergism",
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"Mice",
"Mice, Nude",
"Neoplasm Metastasis",
"Taxoids",
"Xenograft Model Antitumo... | {
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