prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of D830030K20Rik in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | D830030K20Rik | protein/peptide accumulation | Embryonic Cell Line | Gene: D830030K20Rik (RIKEN cDNA D830030K20 gene)
Type: protein-coding
Summary: RIKEN cDNA D830030K20 gene
Gene Ontology:
Pathways:
UniProt: E9PYQ5, Q8BGG1
Entrez ID: 320333 |
Does Knockout of Herpud1 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Herpud1 | cell proliferation | Embryonic Stem Cell Line | Gene: Herpud1 (homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, endoplasmic reticulum calcium ion homeostasis, endoplasmic reticulum unfolded protein response, int... |
Does Knockout of Qpct in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Qpct | protein/peptide distribution | myoblast cell line | Gene: Qpct (glutaminyl-peptide cyclotransferase (glutaminyl cyclase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: acyltransferase activity, glutaminyl-peptide cyclotransferase activity, metal ion binding, transferase activity, zinc ion binding
Pathways: Immun... |
Does Knockout of Lhfpl1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Lhfpl1 | protein/peptide distribution | myoblast cell line | Gene: Lhfpl1 (lipoma HMGIC fusion partner-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane
Pathways:
UniProt: Q80SV1
Entrez ID: 237091 |
Does Knockout of Ubn2 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Ubn2 | protein/peptide distribution | myoblast cell line | Gene: Ubn2 (ubinuclein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q80WC1
Entrez ID: 320538 |
Does Knockout of Ice1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Ice1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Ice1 (interactor of little elongation complex ELL subunit 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of intracellular protein transport, positive regulation of protein-containing complex assembly, positive regulation of transcription by R... |
Does Knockout of Rbp2 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Rbp2 | cell cycle progression | breast epithelium | Gene: Rbp2 (retinol binding protein 2, cellular)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid transport, retinoid metabolic process, triglyceride biosynthetic process; MF: binding, enzyme-substrate adaptor activity, fatty acid binding, lipid binding, molecul... |
Does Knockout of Tuba1a in Immortal mouse chromaffin cells causally result in cell viability? | 1 | 2,469 | Knockout | Tuba1a | cell viability | Immortal mouse chromaffin cells | Gene: Tuba1a (tubulin, alpha 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adult behavior, adult locomotory behavior, cellular response to calcium ion, centrosome cycle, cerebellar cortex morphogenesis, cerebral cortex development, dentate gyrus development, flagell... |
Does Knockout of Tspan13 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Tspan13 | cell proliferation | Colonic Cancer Cell Line | Gene: Tspan13 (tetraspanin 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium channel regulator activity, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9D8C2
Entrez ID: 66109 |
Does Knockout of Taf1c in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Taf1c | phagocytosis | macrophage | Gene: Taf1c (TATA-box binding protein associated factor, RNA polymerase I, C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-speci... |
Does Knockout of Cachd1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 82 | Knockout | Cachd1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cachd1 (cache domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transport; CC: membrane, voltage-gated calcium channel complex
Pathways:
UniProt: Q6PDJ1
... |
Does Knockout of Cd1d2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Cd1d2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cd1d2 (CD1d2 antigen)
Type: protein-coding
Summary: This gene encodes a MHC class I-like molecule involved in the presentation of lipid antigens to T cells, and is involved in the activation of Natural Killer T (NKT) cells. The gene is highly similar to the CD1d1 antigen gene, which is located adj... |
Does Knockout of Ppp2r3a in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,181 | Knockout | Ppp2r3a | tumorigenicity | Colonic Cancer Cell Line | Gene: Ppp2r3a (protein phosphatase 2, regulatory subunit B'', alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eye photoreceptor cell differentiation, negative regulation of canonical Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, pos... |
Does Knockout of Upf1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 684 | Knockout | Upf1 | cell proliferation | Acute Myeloid Leukemia Cell Line | Gene: Upf1 (UPF1 RNA helicase and ATPase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, DNA repair, DNA replication, cell cycle phase transition, cellular response to interleukin-1, cellular response to lipopolysaccharide, histone m... |
Does Knockout of Gpnmb in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Gpnmb | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gpnmb (glycoprotein (transmembrane) nmb)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone mineralization, cell adhesion, cell-cell signaling, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of T cell activation, negative regulat... |
Does Knockout of Klra10 in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Klra10 | response to chemicals | Pancreatic Cancer Cell Line | Gene: Klra10 (killer cell lectin-like receptor subfamily A, member 10)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ont... |
Does Knockout of Mterf3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,289 | Knockout | Mterf3 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mterf3 (mitochondrial transcription termination factor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial ribosome assembly, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of mitochondrial tran... |
Does Knockout of Pde6a in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Pde6a | cell proliferation | Embryonic Stem Cell Line | Gene: Pde6a (phosphodiesterase 6A, cGMP-specific, rod, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cAMP/PKA signal transduction, photoreceptor cell maintenance, retina development in camera-type eye, signal transduction, visual perception... |
Does Knockout of Rpl31-ps12 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 684 | Knockout | Rpl31-ps12 | cell proliferation | Acute Myeloid Leukemia Cell Line | Gene: Rpl31-ps12 (ribosomal protein L31, pseudogene 1 2)
Type: protein-coding
Summary: ribosomal protein L31, pseudogene 1 2
Gene Ontology:
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt:
Entrez ID: 665562 |
Does Knockout of Sec63 in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,271 | Knockout | Sec63 | cell proliferation | Mouse kidney carcinoma cell | Gene: Sec63 (SEC63 homolog, protein translocation regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, liver development, nitrogen cycle metabolic process, post-translational protein targeting to endoplasm... |
Does Knockout of Tpd52l2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Tpd52l2 | cell proliferation | Colonic Cancer Cell Line | Gene: Tpd52l2 (tumor protein D52-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: molecular_function, protein homodimerization activity; CC: cytoplasm, perinuclear region of cytoplasm
Pathways:
UniProt: Q9CYZ2
Entrez ID: 66314 |
Does Knockout of Gak in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,270 | Knockout | Gak | cell proliferation | Melanoma Cell Line | Gene: Gak (cyclin G associated kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, Golgi to lysosome transport, clathrin coat assembly, clathrin coat disassembly, clathrin-dependent endocytosis, endoplasmic reticulum organization, epidermal cell di... |
Does Knockout of Khnyn in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Khnyn | cell viability | Immortal mouse chromaffin cells | Gene: Khnyn (KH and NYN domain containing)
Type: protein-coding
Summary: This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common ... |
Does Knockout of Etl4 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,684 | Knockout | Etl4 | protein/peptide distribution | myoblast cell line | Gene: Etl4 (enhancer trap locus 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton
Pathways:
UniProt: A2AQ25
Entrez ID: 208618 |
Does Knockout of Kcng2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 1 | 2,174 | Knockout | Kcng2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Kcng2 (potassium voltage-gated channel, subfamily G, member 2)
Type: protein-coding
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be part of voltage-gated potassium channel com... |
Does Knockout of Cachd1 in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 2,477 | Knockout | Cachd1 | cell proliferation | Embryonic Stem Cell Line | Gene: Cachd1 (cache domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transport; CC: membrane, voltage-gated calcium channel complex
Pathways:
UniProt: Q6PDJ1
... |
Does Knockout of Cebpz in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Cebpz | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607 |
Does Knockout of Rhd in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Rhd | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rhd (Rh blood group, D antigen)
Type: protein-coding
Summary: Predicted to enable ammonium channel activity. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Located in membrane. Is expressed in several s... |
Does Knockout of Pknox2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Pknox2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Pknox2 (Pbx/knotted 1 homeobox 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA... |
Does Knockout of Polr2m in Mouse cell causally result in protein/peptide accumulation? | 0 | 1,047 | Knockout | Polr2m | protein/peptide accumulation | Mouse cell | Gene: Polr2m (polymerase (RNA) II (DNA directed) polypeptide M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maintenance of ER location, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, molecular_function, transcription elongation f... |
Does Knockout of Esco2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Esco2 | phagocytosis | macrophage | Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2)
Type: protein-coding
Summary: Enables L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Acts upstream of or within several processes, including double-strand break repair; hematopoietic progenitor ce... |
Does Knockout of Rnf111 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Rnf111 | cell proliferation | Mouse kidney carcinoma cell | Gene: Rnf111 (ring finger 111)
Type: protein-coding
Summary: Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein ubiquitination; positive regulation of transforming growth factor beta receptor signaling pathway; and protein po... |
Does Knockout of Hnrnpf in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Hnrnpf | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Hnrnpf (heterogeneous nuclear ribonucleoprotein F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, regulation of RNA splicing; MF: RNA binding, TBP-class protein binding, nucleic acid binding, single-stranded RNA binding; CC: catalytic... |
Does Knockout of Babam2 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 684 | Knockout | Babam2 | cell proliferation | Acute Myeloid Leukemia Cell Line | Gene: Babam2 (BRISC and BRCA1 A complex member 2)
Type: protein-coding
Summary: Enables tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; mitotic G2 DNA damage checkpoint signaling; and positive regulation o... |
Does Knockout of Crtap in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Crtap | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Crtap (cartilage associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: collagen fibril organization, negative regulation of post-translational protein modification, protein folding, protein stabilization, spermatogenesis; MF: collagen binding, protein ... |
Does Knockout of Cd44 in Melanoma Cell Line causally result in cell proliferation? | 1 | 1,157 | Knockout | Cd44 | cell proliferation | Melanoma Cell Line | Gene: Cd44 (CD44 antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, Wnt signaling pathway, anatomical structure morphogenesis, branching involved in prostate gland morphogenesis, branching involved in ureteric bud morphogenesis, cell adhesion, cel... |
Does Knockout of Rcor1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 2,477 | Knockout | Rcor1 | cell proliferation | Embryonic Stem Cell Line | Gene: Rcor1 (REST corepressor 1)
Type: protein-coding
Summary: Enables chromatin binding activity; enzyme binding activity; and transcription corepressor activity. Involved in erythrocyte differentiation; negative regulation of gene expression; and positive regulation of megakaryocyte differentiation. P... |
Does Knockout of Prss34 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Prss34 | cell proliferation | Mouse kidney carcinoma cell | Gene: Prss34 (serine protease 34)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: glycosaminoglycan binding, heparin binding, hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular mat... |
Does Knockout of Rps7 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Rps7 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Rps7 (ribosomal protein S7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of ubiquitin-dependent protein catabolic process, neural crest cell differentiation, neural tube closure, positive regulation of gene expression,... |
Does Knockout of Tas2r103 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Tas2r103 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tas2r103 (taste receptor, type 2, member 103)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sens... |
Does Knockout of Tmem39a in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Tmem39a | response to virus | Embryonic Fibroblast Cell Line | Gene: Tmem39a (transmembrane protein 39a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, negative regulation of autophagosome assembly, negative regulation of autophagosome maturation, positive regulation of viral genome replication; CC: endoplasmic reticulum,... |
Does Knockout of Pgm5 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Pgm5 | protein/peptide distribution | Microglial Cell Line | Gene: Pgm5 (phosphoglucomutase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell adhesion, myofibril assembly, striated muscle tissue development; MF: magnesium ion binding, phosphoglucomutase activity, protein binding; CC: Z disc, ad... |
Does Knockout of Rprd1b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Rprd1b | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rprd1b (regulation of nuclear pre-mRNA domain containing 1B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, mRNA 3'-end processing, positive regulation of cell population proliferation, positive regulation of transcription by R... |
Does Knockout of Clec3a in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Clec3a | cell proliferation | Regulatory T cell | Gene: Clec3a (C-type lectin domain family 3, member a)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q9EPW4
Entrez ID: 403395 |
Does Knockout of Btnl9 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Btnl9 | cell proliferation | Mouse kidney carcinoma cell | Gene: Btnl9 (butyrophilin-like 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, regulation of cytokine production; CC: external side of plasma membrane, membrane
Pathways: Adaptive Immune System, Butyrophilin (BTN) family inte... |
Does Knockout of Ssty1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 1 | 165 | Knockout | Ssty1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Ssty1 (spermiogenesis specific transcript on the Y 1)
Type: protein-coding
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in cytosol and nucleoplasm. [provided by Alliance of Genome Res... |
Does Knockout of Gpi1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,681 | Knockout | Gpi1 | protein/peptide distribution | myoblast cell line | Gene: Gpi1 (glucose-6-phosphate isomerase 1)
Type: protein-coding
Summary: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm,... |
Does Knockout of Lonp1 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Lonp1 | cell proliferation | Regulatory T cell | Gene: Lonp1 (lon peptidase 1, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, chaperone-mediated protein complex assembly, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of ins... |
Does Knockout of F2rl3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | F2rl3 | cell proliferation | Mouse kidney carcinoma cell | Gene: F2rl3 (F2R like thrombin or trypsin receptor 3)
Type: protein-coding
Summary: This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-termina... |
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