Mardiyyah/variant-tapt_freeze_llrd-LR_5e-05
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PMCID stringlengths 10 10 | Title stringlengths 46 162 | FullText stringlengths 17.4k 118k |
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PMC4802042 | A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation | Mitogen-activated protein kinases (MAPKs), important in a large array of signalling pathways, are tightly controlled by a cascade of protein kinases and by MAPK phosphatases (MKPs). MAPK signalling efficiency and specificity is modulated by protein–protein interactions between individual MAPKs and the docking motifs in... |
PMC4968113 | Structural diversity in a human antibody germline library | To support antibody therapeutic development, the crystal structures of a set of 16 germline variants composed of 4 different kappa light chains paired with 4 different heavy chains have been determined. All four heavy chains of the antigen-binding fragments (Fabs) have the same complementarity-determining region (CDR) ... |
PMC4854314 | RNA protects a nucleoprotein complex against radiation damage | Systematic analysis of radiation damage within a protein–RNA complex over a large dose range (1.3–25 MGy) reveals significant differential susceptibility of RNA and protein. A new method of difference electron-density quantification is presented.With the wide use of high-flux third-generation synchrotron sources, radia... |
PMC4792962 | A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome | Biogenesis of the 20S proteasome is tightly regulated. The N-terminal propeptides protecting the active-site threonines are autocatalytically released only on completion of assembly. However, the trigger for the self-activation and the reason for the strict conservation of threonine as the active site nucleophile remai... |
PMC4937829 | Visualizing chaperone-assisted protein folding | "Challenges in determining the structures of heterogeneous and dynamic protein complexes have greatl(...TRUNCATED) |
PMC4848761 | Predictive features of ligand‐specific signaling through the estrogen receptor | "Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue(...TRUNCATED) |
PMC4869123 | Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide | "IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory disea(...TRUNCATED) |
PMC4841544 | "Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococ(...TRUNCATED) | "Neisseria adhesin A (NadA) is present on the meningococcal surface and contributes to adhesion to a(...TRUNCATED) |
PMC4822561 | "Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae(...TRUNCATED) | "Crystal structures of the cleavage complexes of topoisomerase IV from Gram-negative (K. pneumoniae)(...TRUNCATED) |
PMC4850273 | Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont | "Polysaccharide utilization loci (PUL) within the genomes of resident human gut Bacteroidetes are ce(...TRUNCATED) |
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