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### Question: what are the BRCA1 gene mutations reported in Breast cancer patients?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological process... |
### Question: what are the BRCA1 gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other importa... |
### Question: what are the PIK3CA gene mutations reported in Breast cancer patients at stage iv?### Answer: Stage IV is the most advanced stage of breast cancer. It has spread to nearby lymph nodes and to distant parts of the body beyond the breastThe mutation with gene PIK3CA in stage iv are H1047R,H1047R,E545K,H104... |
### Question: what are the PIK3CA gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: PIK3CA is the most recurrently mutated gene in breast cancer, and has been found to important in a number of cancer types. An integral part of the PI3K pathway, PIK3CA has long been described as an ... |
### Question: what are the protein terminating mutations in BRCA1 gene of breast cancer patients?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiol... |
### Question: what are the protein terminating mutations in BRCA1 gene of breast cancer patients at stage iib?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other impo... |
### Question: what are the protein altering mutations in BRCA1 gene of breast cancer patients?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiolog... |
### Question: what are the ATM gene mutations reported in Breast cancer patients?### Answer: The ATM variants are associated with an increased risk of breast cancer. Mutations in the ATM gene caused Ataxia Telangiectasia (A-T), an autosomal recessive syndrome that patients have symptoms such as ionizing radiation sen... |
### Question: what are the ATM gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: The ATM variants are associated with an increased risk of breast cancer. Mutations in the ATM gene caused Ataxia Telangiectasia (A-T), an autosomal recessive syndrome that patients have symptoms such a... |
### Question: what are the protein altering mutations in BRCA1 gene of breast cancer patients?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiolog... |
### Question: what are the PALB2 gene mutations reported in Breast cancer patients?### Answer: The PALB2 gene makes a protein that interacts with the protein made by the BRCA2 gene. Mutations in this gene can lead to a higher risk of breast cancer.The mutation with gene PALB2G971R,Q1146*,K974K,L381V,G115E,S865S,I84I,... |
### Question: what are the PALB2 gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: The PALB2 gene makes a protein that interacts with the protein made by the BRCA2 gene. Mutations in this gene can lead to a higher risk of breast cancer. The mutation with gene PALB2 with stop_gained... |
### Question: what are the protein altering mutations in PALB2 gene of breast cancer patients?### Answer: The PALB2 gene makes a protein that interacts with the protein made by the BRCA2 gene. Mutations in this gene can lead to a higher risk of breast cancer.The protein altering mutation with gene PALB2 are G971R,L3... |
### Question: what are the BRCA2 gene mutations reported in Breast cancer patients?### Answer: BRCA2 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been shown to increase the risk for these can... |
### Question: what are the BRCA2 gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: BRCA2 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been shown to increas... |
### Question: what are the protein altering mutations in BRCA2 gene of breast cancer patients?### Answer: BRCA2 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been shown to increase the risk f... |
### Question: what are the CHEK2 gene mutations reported in Breast cancer patients?### Answer: The CHEK2 gene is an important gene that normally helps with DNA repair. A CHEK2 mutation increases breast cancer risk.The mutation with gene CHEK2 are I276N,R346C,Q69*,,L191L,,E308Q,D77H,D203E |
### Question: what are the CHEK2 gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: The CHEK2 gene is an important gene that normally helps with DNA repair. A CHEK2 mutation increases breast cancer risk.The mutation with gene CHEK2 with stop_gained effect is Q69* |
### Question: what are the protein altering mutations in CHEK2 gene of breast cancer patients?### Answer: The CHEK2 gene is an important gene that normally helps with DNA repair. A CHEK2 mutation increases breast cancer risk.The protein altering mutation with gene CHEK2 are I276N,R346C,E308Q,D77H,D203E |
### Question: what are the PTEN gene mutations reported in Breast cancer patients?### Answer: Phosphatase and tensin homolog deleted on chromosome ten (PTEN), the negative regulator of the proto-oncogenic phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, constitutes one of the most intriguing tumor... |
### Question: what are the PTEN gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: Phosphatase and tensin homolog deleted on chromosome ten (PTEN), the negative regulator of the proto-oncogenic phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, constitutes one of t... |
### Question: what are the protein altering mutations in PTEN gene of breast cancer patients?### Answer: The PTEN gene normally helps regulate cell growth. Inherited mutations in this gene can cause Cowden syndrome, a rare disorder that puts people at higher risk for both cancer and benign (non-cancer) tumors in the... |
### Question: what are the ARID1A gene mutations reported in Breast cancer patients?### Answer: The SWItch mating type/Sucrose Non-Fermenting (SWI/SNF) family, a member of chromatin remodeling complexes. A high prevalence of mutations in SWI/SNF chromatin remodeling complexes has been found in 20 25% of all human can... |
### Question: what are the protein altering mutations in ARID1A gene of breast cancer patients?### Answer: The SWItch mating type/Sucrose Non-Fermenting (SWI/SNF) family, a member of chromatin remodeling complexes. A high prevalence of mutations in SWI/SNF chromatin remodeling complexes has been found in 20 25% of a... |
### Question: what are the ARID1A gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: The SWItch mating type/Sucrose Non-Fermenting (SWI/SNF) family, a member of chromatin remodeling complexes. A high prevalence of mutations in SWI/SNF chromatin remodeling complexes has been found in... |
### Question: what are the TP53 gene mutations reported in Breast cancer patients with stop_gained effect at stage iib?### Answer: Stage II describes cancer that is in a limited region of the breast but has grown larger. It reflects how many lymph nodes may contain cancer cells.TP53 is the most frequently mutated gen... |
### Question: what are the protein altering mutations in TP53 gene at stage iib of breast cancer patients?### Answer: TP53 is the most frequently mutated gene in cancer. TP53 codes for the transcription factor p53, which initiates transcription of genes involved in processes such as cell cycle arrest, apoptosis, met... |
### Question: what are the ESR1 gene mutations reported in Breast cancer patients?### Answer: Preclinical and clinical studies have demonstrated that ESR1 mutations can pre-exist in primary tumors and can be enriched during metastasis. Furthermore, ESR1 mutations express a unique transcriptional profile that favors t... |
### Question: what are the protein altering mutations in ESR1 gene of breast cancer patients?### Answer: Preclinical and clinical studies have demonstrated that ESR1 mutations can pre-exist in primary tumors and can be enriched during metastasis. Furthermore, ESR1 mutations express a unique transcriptional profile t... |
### Question: what are the AKT1 gene mutations reported in Breast cancer patients?### Answer: AKT1 is a member of the serine-threonine kinase class that plays a key role in cellular processes, including growth, proliferation, survival, and angiogenesis. It is a downstream mediator of phosphatidylinositol 3-kinase whi... |
### Question: what are the protein altering mutations in AKT1 gene of breast cancer patients?### Answer: AKT1 is a member of the serine-threonine kinase class that plays a key role in cellular processes, including growth, proliferation, survival, and angiogenesis. It is a downstream mediator of phosphatidylinositol ... |
### Question: what are the RB1 gene mutations reported in Breast cancer patients?### Answer: The tumor suppressor RB1 is often lost by mutation, deletion or transcriptional silencing as well as by hyper-phosphorylation of its gene product, pRb, in many human malignancies. Indeed, it is deleted or rearranged in 20 25%... |
### Question: what are the RB1 gene mutations reported in Breast cancer patients with stop_gained effect?### Answer: The tumor suppressor RB1 is often lost by mutation, deletion or transcriptional silencing as well as by hyper-phosphorylation of its gene product, pRb, in many human malignancies. Indeed, it is deleted... |
### Question: what are the protein altering mutations in RB1 gene of breast cancer patients?### Answer: The tumor suppressor RB1 is often lost by mutation, deletion or transcriptional silencing as well as by hyper-phosphorylation of its gene product, pRb, in many human malignancies. Indeed, it is deleted or rearrang... |
### Question: what are the ORC1 gene mutations reported in Breast cancer patients?### Answer: ORC1 is the largest subunit of ORC complex required to initiate DNA replication.The mutation with gene ORC1 are Q369H,K739N,R477Q,V133A,D75Efs*13,N442D,Q556K,T455T,L176F,G534S,A592Qfs*41 |
### Question: what are the protein altering mutations in ORC1 gene of breast cancer patients?### Answer: ORC1 is the largest subunit of ORC complex required to initiate DNA replication.The protein altering mutation with gene ORC1 are Q369H,K739N,R477Q,V133A,N442D,Q556K,L176F,G534S |
### Question: what are the mutations in gene ESR1 for females with age 80 and above reported in breast cancer patients?### Answer: Preclinical and clinical studies have demonstrated that ESR1 mutations can pre-exist in primary tumors and can be enriched during metastasis. Furthermore, ESR1 mutations express a unique ... |
### Question: what are the mutations in gene ORC1 for females with age 80 and above reported in Breast cancer patients?### Answer: ORC1 is the largest subunit of ORC complex required to initiate DNA replication.The mutation with gene ORC1 for females with age 80 and above is R477Q |
### Question: what are the mutations in gene BRCA1 for females with age 80 and above reported in Breast cancer patients?### Answer: Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and ... |
### Question: what are the mutations in gene BRCA2 for females with age 80 and above reported in Breast cancer patients?### Answer: BRCA2 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been sho... |
### Question: what are the mutations in gene ATM for females with age 80 and above reported in Breast cancer patients?### Answer: The ATM variants are associated with an increased risk of breast cancer. Mutations in the ATM gene caused Ataxia Telangiectasia (A-T), an autosomal recessive syndrome that patients have sy... |
### Question: what are the mutations in gene CHEK2 for females with age 70 and above reported in breast cancer patients?### Answer: The CHEK2 gene is an important gene that normally helps with DNA repair. A CHEK2 mutation increases breast cancer risk.The mutation with gene CHEK2 for females with age 70 and above are ... |
### Question: what are the mutations in gene PTEN for females with age 80 and above reported in Breast cancer patients?### Answer: Phosphatase and tensin homolog deleted on chromosome ten (PTEN), the negative regulator of the proto-oncogenic phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, constit... |
### Question: what are the mutations in gene TP53 for females with age 80 and above reported in Breast cancer patients?### Answer: TP53 is the most frequently mutated gene in cancer. TP53 codes for the transcription factor p53, which initiates transcription of genes involved in processes such as cell cycle arrest, ap... |
### Question: what are the mutations in gene TP53 for females with age 80 and above reported in Breast cancer patients?### Answer: TP53 is the most frequently mutated gene in cancer. TP53 codes for the transcription factor p53, which initiates transcription of genes involved in processes such as cell cycle arrest, ap... |
### Question: what are the protein terminating mutations in ATM gene of breast cancer patients?### Answer: The ATM variants are associated with an increased risk of breast cancer. Mutations in the ATM gene caused Ataxia Telangiectasia (A-T), an autosomal recessive syndrome that patients have symptoms such as ionizing... |
### Question: what are the protein terminating mutations in CHEK2 gene of breast cancer patients?### Answer: The CHEK2 gene is an important gene that normally helps with DNA repair. A CHEK2 mutation increases breast cancer risk.The mutation with gene CHEK2 with protein terminating mutations is Q69* |
### Question: what are the protein terminating mutations in PTEN gene of breast cancer patients?### Answer: Phosphatase and tensin homolog deleted on chromosome ten (PTEN), the negative regulator of the proto-oncogenic phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, constitutes one of the most in... |
### Question: what are the protein terminating mutations in ARID1A gene of breast cancer patients?### Answer: The SWItch mating type/Sucrose Non-Fermenting (SWI/SNF) family, a member of chromatin remodeling complexes. A high prevalence of mutations in SWI/SNF chromatin remodeling complexes has been found in 20 25% of... |
### Question: what are the protein terminating mutations in BRCA2 gene of breast cancer patients?### Answer: BRCA2 mutations in the germline have become a hallmark for hereditary breast and ovarian cancers. Variants that have been demonstrated to reduce the function of the protein have been shown to increase the risk... |
### Question: what are the protein terminating mutations in PALB2 gene of breast cancer patients?### Answer: The PALB2 gene makes a protein that interacts with the protein made by the BRCA2 gene. Mutations in this gene can lead to a higher risk of breast cancer. The mutation with gene PALB2 with stop_gained effect is... |
### Question: what are the protein terminating mutations in PIK3CA gene of breast cancer patients?### Answer: PIK3CA is the most recurrently mutated gene in breast cancer, and has been found to important in a number of cancer types. An integral part of the PI3K pathway, PIK3CA has long been described as an oncogene, ... |
### Question: what are the protein terminating mutations in RB1 gene of breast cancer patients?### Answer: The tumor suppressor RB1 is often lost by mutation, deletion or transcriptional silencing as well as by hyper-phosphorylation of its gene product, pRb, in many human malignancies. Indeed, it is deleted or rearra... |
### Question: what are the gene associated with homologous recombination deficiency?### Answer: The genes associated with homologous recombination deficiency are ARID1A, ATM, ATRX, BAP1, BARD1, BLM, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, MRE11A, NBN, PALB2, RAD50, RAD51, ... |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: The most common cause of hereditary breast cancer is an inherited mutation in the BRCA1 or BRCA2 gene. In normal cells, these genes help make proteins that repair damaged DNA. Mutated versions of these genes can lead ... |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: The ATM gene normally helps repair damaged DNA (or helps kill the cell if the damaged can't be fixed). Inheriting 2 abnormal copies of this gene causes the disease ataxia-telangiectasia. Inheriting one abnormal copy o... |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: The PALB2 gene makes a protein that interacts with the protein made by the BRCA2 gene. Mutations in this gene can lead to a higher risk of breast cancer. |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: The TP53 gene helps stop the growth of cells with damaged DNA. Inherited mutations of this gene cause Li-Fraumeni syndrome. People with this syndrome have an increased risk of breast cancer, as well as some other canc... |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: The CHEK2 gene is another gene that normally helps with DNA repair. A CHEK2 mutation increases breast cancer risk. |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: The PTEN gene normally helps regulate cell growth. Inherited mutations in this gene can cause Cowden syndrome, a rare disorder that puts people at higher risk for both cancer and benign (non-cancer) tumors in the brea... |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: Inherited mutations in this gene cause hereditary diffuse gastric cancer, a syndrome in which people develop a rare type of stomach cancer. Women with mutations in this gene also have an increased risk of invasive lob... |
### Question: what are the inherited gene mutations that can increase breast cancer risk?### Answer: Defects in this gene can lead to Peutz-Jeghers syndrome. People affected with this disorder have pigmented spots on their lips and in their mouths, polyps (abnormal growths) in the urinary and digestive tracts, and a ... |
### Question: What are the FDA approved therapies and response rate available for metastatic triple negative breast cancer patient who had received two prior treatments for metastatic diasease?### Answer: The FDA approved Trodelvy based on the results of a clinical trial of 108 patients. The efficacy of Trodelvy was ... |
### Question: What are the FDA approved therapies available for metastatic triple negative breast cancer patient who is not responding to other treatments?### Answer: Metastatic triple-negative breast cancer is an aggressive form of breast cancer with limited treatment options. Chemotherapy has been the mainstay of t... |
### Question: What are the FDA approved therapies available for metastatic triple negative breast cancer patient who is not responding to other treatments?### Answer: Trodelvy is FDA approved therapy for metastatic triple negative breast cancer patient who is not responding to other treatments.Trodelvy is a Trop-2-di... |
### Question: What is the response rate of Trodelvy for metastatic triple negative breast cancer patient who had received two prior treatments for metastatic diasease?### Answer: a clinical trial of 108 patients showed The efficacy of Trodelvy was based on the overall response rate ORR) which reflects the percentag... |
### Question: What is the primary efficacy endpoint of sacituzumab govitecan for patients with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) who have received two or more prior systemic therapies, at least one of them for metastatic disease?### Answer: The primary efficacy endpoin... |
### Question: what is the FDA approved therapy for residual invasive HER2 positive breast cancer after neoadjuvant therapy?### Answer: Trastuzumab emtansine(T-DM1) for patients with early-stage high-risk HER2-positive breast cancer with residual disease after neoadjuvant therapy with trastuzumab and taxane-based trea... |
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