doi stringlengths 28 28 | title stringlengths 19 311 | abstract stringlengths 217 5.08k | plain language summary stringlengths 115 4.83k | article stringlengths 3.87k 161k |
|---|---|---|---|---|
10.1371/journal.ppat.1004874 | Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive Fitness | Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and selective mechanisms that are incompletely understood. Defining how natural selection shapes RNA virus populations is crit... | Viruses are constantly emerging into new areas and pose significant challenges to public health. Chikungunya and West Nile viruses (WNV), both mosquito-borne RNA viruses, are quintessential examples of how increased globalization has facilitated the expansion of viruses into new territories. Rapid evolution of both of ... | RNA viruses pose some of the most complex, persistent and challenging problems facing public health and medicine. The ongoing outbreaks of avian influenza A(H7N9) virus (Orthomyxoviridae) in China [1], Ebola virus (Filoviridae) in West Africa [2], and chikungunya virus (CHIKV, Togaviridae, Alphavirus) and West Nile vir... |
10.1371/journal.pntd.0007210 | Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals | Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental a... | West Nile virus (WNV) is a mosquito-borne virus that causes significant disease and death every year in humans, domesticated animals, and wildlife. Control of WNV transmission is focused on controlling the mosquito vector through applications of insecticides directly to the environment. In this study, we evaluate a nov... | West Nile virus (WNV) is an arthropod-borne flavivirus, and the leading cause of domestically acquired arboviral disease in the United States [1,2], resulting in significant disease and death every year in humans, domesticated animals, and wildlife. From 1999–2017, >48,000 cases of human WNV disease and >2000 deaths we... |
10.1371/journal.pntd.0005622 | Rapid deployment of a mobile biosafety level-3 laboratory in Sierra Leone during the 2014 Ebola virus epidemic | Ebola virus emerged in West Africa in December 2013. The high population mobility and poor public health infrastructure in this region led to the development of the largest Ebola virus disease (EVD) outbreak to date.
On September 26, 2014, China dispatched a Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) and a well-t... | A Mobile Biosafety Level-3 Laboratory (MBSL-3 Lab) and a well-trained diagnostic team were dispatched to Sierra Leone to assist in Ebola virus disease (EVD) diagnosis when the largest outbreak of EVD to date emerged in West Africa in 2014. This setup allowed for the diagnosis of suspected EVD cases in less than 4 hours... | Ebola virus belongs to the Filoviridae family of enveloped viruses and contains a non-segmented negative-strand RNA genome [1,2]. Infection in humans can cause Ebola hemorrhagic fever, with exceptionally high case-fatality rates of more than 50% [3,4]. The incubation period of Ebola virus disease (EVD) is 2 to 21 days ... |
10.1371/journal.ppat.0030058 | Identification of a CCR5-Expressing T Cell Subset That Is Resistant to R5-Tropic HIV Infection | Infection with HIV-1 perturbs homeostasis of human T cell subsets, leading to accelerated immunologic deterioration. While studying changes in CD4+ memory and naïve T cells during HIV-1 infection, we found that a subset of CD4+ effector memory T cells that are CCR7−CD45RO−CD45RA+ (referred to as TEMRA cells), was signi... | HIV-1 infection profoundly perturbs the immune system and is characterized by depletion of CD4+ T cells and chronic immune activation, which lead to AIDS. Although HIV-1 targets CD4+ T cells, it also requires a second receptor in order to infect the target cells. The majority of HIV-1 strains that are transmitted use a... | Chronic immune activation and homeostatic disturbance of T cell subsets that accompany viral replication are hallmarks of HIV-1 infection [1–4]. The cause and implications of these profound quantitative and qualitative changes in CD4+ memory T cell subsets during HIV-1 infection are still not well understood [2]. Eluci... |
10.1371/journal.ppat.1007876 | Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8 | The guanylate-binding proteins (GBPs) belong to the dynamin superfamily of GTPases and function in cell-autonomous defense against intracellular pathogens. IpaH9.8, an E3 ligase from the pathogenic bacterium Shigella flexneri, ubiquitinates a subset of GBPs and leads to their proteasomal degradation. Here we report the... | Shigella flexneri is a Gram-negative bacteria that causes diarrhea in humans and leads to a million deaths every year. Once inside the cell, S. flexneri injects the host cell cytoplasm with effector proteins to suppress host defense. The guanylate-binding proteins (GBPs) have potent antimicrobial functions against a nu... | The guanylate-binding proteins (GBPs) play critical roles in cell-autonomous immunity against a diverse range of bacterial, viral, and protozoan pathogens. The charter member of this family is GBP1, which was identified as a protein that is strongly induced by the interferons and can specifically bind to the guanylate ... |
10.1371/journal.pgen.1003185 | Genetic Disruption of the Copulatory Plug in Mice Leads to Severely Reduced Fertility | "Seminal fluid proteins affect fertility at multiple stages in reproduction. In many species, a male(...TRUNCATED) | "Male reproductive fitness is strongly affected by seminal fluid. In many animals, the male's ejacul(...TRUNCATED) | "The non-sperm component of an ejaculate can have large effects on male reproductive fitness. In int(...TRUNCATED) |
10.1371/journal.pbio.2006601 | Heterogeneity and longevity of antibody memory to viruses and vaccines | "Determining the duration of protective immunity requires quantifying the magnitude and rate of loss(...TRUNCATED) | "Immunological memory, mediated by antibodies, is a hallmark of immunity. A key problem for determin(...TRUNCATED) | "Immune memory is a cardinal feature of the adaptive immune response of vertebrates and is the princ(...TRUNCATED) |
10.1371/journal.ppat.1002062 | Bacteria-Induced Dscam Isoforms of the Crustacean, Pacifastacus leniusculus | "The Down syndrome cell adhesion molecule, also known as Dscam, is a member of the immunoglobulin su(...TRUNCATED) | "Invertebrate animals lack an adaptive immune system and have no antibodies. Vertebrate antibodies b(...TRUNCATED) | "The immunoglobulin super family (IgSF) is composed of proteins that contain at least one immunoglob(...TRUNCATED) |
10.1371/journal.ppat.1005075 | "Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administrati(...TRUNCATED) | "Vaginal HIV transmission accounts for the majority of new infections worldwide. Currently, multiple(...TRUNCATED) | "When taken consistently, PrEP has been shown to reduce the risk of HIV infection by up to 92% in pe(...TRUNCATED) | "Although the annual number of new HIV infections continues to decline, the global HIV-1 pandemic re(...TRUNCATED) |
10.1371/journal.ppat.1002361 | Signal Transduction through CsrRS Confers an Invasive Phenotype in Group A Streptococcus | "The CsrRS (or CovRS) two component system controls expression of up to 15% of the genome of group A(...TRUNCATED) | "Group A Streptococcus (S. pyogenes or GAS) is exclusively a human pathogen that can inhabit the hum(...TRUNCATED) | "Human beings are thought to be the principal if not exclusive host for group A Streptococcus (S. py(...TRUNCATED) |
End of preview. Expand in Data Studio
This is the dataset used in the paper "Readability Controllable Biomedical Document Summarization" by Zheheng Luo, Qianqian Xie, Sophia Ananiadou. Every instance in the dataset contains a technical summary(abstract), a plain language summary, and the whole article text. All the data are from the PLOS journals.
Detailed format is as following:
{
"doi": str, # unique doi identifier
"title": str, # title
"abstract": str, # abstract
"plain language summary": str, # plain language summary
"article": str # whole text
}
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