IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels float64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q92542 | P49810 | 1 | binding | up-regulates | 0.941 | Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with presenilin 1 and presenilin 2. | SIGNOR-81936 |
P62873 | P59768 | 2 | binding | up-regulates activity | 0.94 | GNB1 dissociates from the receptor, bound with GNG2 as stable dimer | SIGNOR-251105 |
P12956 | P78527 | 2 | relocalization | up-regulates | 0.94 | Ku and dna-pkcs only interact in the presence of dna and recruitment of dna-pkcs to sites of dna damage in vivo is ku-dependent. Inward translocation of ku allows dna-pkcs to interact with the extreme termini of the dna, allowing two dna-pkcs molecules to interact across the dsb in a so-called synaptic complex . This i... | SIGNOR-183276 |
P59768 | P62873 | 2 | binding | up-regulates activity | 0.94 | GNG2 dissociates from the activated receptor, bound with GNB1 as stable dimer. | SIGNOR-251106 |
P78527 | P12956 | 2 | phosphorylation | up-regulates activity | 0.94 | Ku70 phosphorylation occurs within minutes of genotoxic stress and involves DNA-PKcs and/or ATM kinase activities.By using specific vectors enabling the simultaneous shRNA-mediated inhibition of endogenous Ku70 and the expression of exogenous Ku70 resistant to shRNA (i.e. S27-S33-Ku70 and A27-A33-Ku70 expressing cells)... | SIGNOR-274023 |
Q14289 | P49023 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.94 | P130Cas and paxillin can be phosphorylated by Fak or Pyk2, and bind directly to these kinases. | SIGNOR-279272 |
P34130 | Q16620 | 1 | binding | up-regulates | 0.94 | Its interactions with trkb can be distinguished from those of brain-derived neurotrophic factor (bdnf) with trkb. | SIGNOR-31644 |
Q15633 | Q9UPY3 | 1 | binding | up-regulates | 0.94 | Dicer and trbp interact in vivo and in vitro /our data indicate that trbp is primarily required for the assembly and/or functioning of si? Or mi?RISCs In mammalian cells, but it may also facilitate the cleavage of pre?miRNAs By dicer. | SIGNOR-140226 |
Q8WW43 | Q92542 | 1 | binding | up-regulates | 0.94 | By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and carboxyl-terminal fragments in human cell lines and in rat brain.These data ... | SIGNOR-93307 |
P98170 | P42574 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.939 | Xiap promotes the degradation of active-form caspase-3, but not procaspase-3, in living cells. Both the association of XIAP with caspase-3 and the RING finger domain of XIAP were essential for ubiquitination. XIAP promotes the degradation of caspase-3, which enhances its anti-apoptotic effect. | SIGNOR-109243 |
Q7RTN6 | Q15831 | 2 | phosphorylation | up-regulates quantity | 0.939 | Furthermore, interaction of STRAD with LKB1 promoted LKB1 phosphorylation at a PKA site S431 and elevated the LKB1 level, and overexpressing LKB1 with a serine-to-alanine mutation at S431 (LKB1 (S431A)) prevented axon differentiation. | SIGNOR-280149 |
Q15831 | Q7RTN6 | 2 | phosphorylation | up-regulates activity | 0.939 | Endogenous LKB1 and STRAD form a complex in which STRAD activates LKB1, resulting in phosphorylation of both partners.LKB1 phosphorylates STRAD at Thr329 and Thr419 | SIGNOR-261950 |
Q13541 | P06730 | 1 | binding | down-regulates activity | 0.939 | The rate-limiting factor for translation is eukaryotic translation initiation factor 4E (eIF4E), which is negatively regulated by eIF4E-binding protein 1 (4E-BP1). | SIGNOR-167176 |
Q99570 | Q8NEB9 | 1 | binding | up-regulates | 0.939 | Recombinant p150 associated with ptdins 3-kinase in vitro in a stable manner, resulting in a 2-fold increase in lipid kinase activity. | SIGNOR-45664 |
P51532 | Q8TAQ2 | 1 | binding | up-regulates | 0.939 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65444 |
P09603 | P07333 | 1 | binding | up-regulates activity | 0.938 | The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34) | SIGNOR-255568 |
O00512 | P35222 | 1 | binding | up-regulates | 0.938 | The transcriptional activity of beta-catenin depends on bcl-9. Bcl-9 functions in targeting beta-catenin to the nucleus and thus increases the transcriptional activity of beta-catenin | SIGNOR-126059 |
O14965 | Q9Y6A5 | 1 | phosphorylation | up-regulates activity | 0.937 | We show that this conserved serine on human TACC3 (Ser(558)) is also phosphorylated by Aurora A. Moreover, phosphorylation of TACC3 by Aurora A in human cells is essential for its proper localization to centrosomes and proximal mitotic spindles. Inhibition of Aurora A with the selective small molecule inhibitor MLN8054... | SIGNOR-262655 |
P13501 | P51681 | 1 | binding | up-regulates activity | 0.937 | CCL5, also known RANTES (regulated on activation, normal T cell expressed and secreted), is a potent chemoattractant for a variety of leukocytes, including T cells, mono- cytes, NK cells, and basophils, signaling via the CCR1, CCR3, and CCR5 cell surface receptors [59]. Among these receptors, CCL5 has the highest affin... | SIGNOR-277726 |
P23443 | P62753 | 1 | phosphorylation | up-regulates activity | 0.937 | A knockin mouse carrying mutations at all phosphorylation sites in the primary s6k substrate, ribosomal protein s6 (rps6), has provided insight into the physiological role of this protein phosphorylation event. Of the many known substrates of s6k1, it is rps6 that has been shown to be directly involved, via its phospho... | SIGNOR-135176 |
O95352 | O94817 | 1 | binding | up-regulates | 0.937 | Analogous to ubiquitination, atg12 is conjugated to atg5 by atg7--an e1-like protein--and atg10--an e2-like protein. | SIGNOR-180132 |
O95786 | Q7Z434 | 1 | binding | up-regulates activity | 0.937 | Initially, RIG-I and MDA5 sense dsRNA in the cytoplasm, produced as a by-product of RNA virus replication.Once one or both of these sensors are activated, they interact with a mitochondrial membrane protein called MAVS (mitochondrial antiviral) (also called IPS1, Cardif, and VISA). They signal to the mitochondrial memb... | SIGNOR-260139 |
P20827 | P29317 | 1 | binding | up-regulates | 0.937 | Ephrin-a1 binds and activates the tyrosine kinase activity of eph-a2, and has a dissociation constant of 20_30 nm | SIGNOR-56901 |
Q15628 | Q13546 | 1 | binding | up-regulates activity | 0.937 | We show that tradd interacts strongly with rip;rip is a serinethreonine kinase that is recruited by tradd to tnfr1 in a tnf-dependent process. | SIGNOR-40043 |
Q9NYJ8 | O43318 | 1 | binding | up-regulates activity | 0.936 | Our results indicate that two distinct TAK1 complexes are present in cells. One comprises TAK1 complexed with TAB1 and TAB2, and the other TAK1 complexed with TAB1 and TAB3. Both complexes are activated in response to tumour necrosis factor-alpha or interleukin-1 in human epithelial KB cells or bacterial lipopolysaccha... | SIGNOR-120268 |
P42336 | P27986 | 2 | phosphorylation | up-regulates activity | 0.936 | We find that p110 alpha phosphorylates p85 alpha Ser608 in vivo with significant stoichiometry. However, p110 beta is far less efficient at phosphorylating p85 alpha Ser608, identifying a potential difference in the mechanisms by which these two isoforms are regulated. The p85 alpha Ser608 phosphorylation was increased... | SIGNOR-276004 |
Q8NEB9 | Q14457 | 1 | binding | up-regulates activity | 0.936 | The beclin 1-vps34 interaction regulates autophagy. | SIGNOR-184521 |
P27986 | P42336 | 2 | binding | up-regulates activity | 0.936 | Signal transduction pathways triggered by Tie2 have been extensively examined. Tyr-1101of Tie2 directly associates in a phosphotyrosine (pTyr)-dependent manner with the p85 regulatory subunit of phosphatidylinositol (PI) 3-kinase, which in turn activate PI 3-kinase, leading to cell motility and survival | SIGNOR-242637 |
Q9NZQ7 | Q15116 | 1 | binding | up-regulates | 0.936 | Pd-l1, was found to bind pd-1 specifically. The functional significance of this interaction has been demonstrated in t cell assays, in which engagement of pd-1 by pd-l1 leads to the inhibition of tcr-mediated lymphocyte proliferation and cytokine secretion. | SIGNOR-82604 |
P51671 | P51677 | 1 | binding | up-regulates | 0.936 | Eotaxin (CCL11) is a specific ligand for CCR3 and serves as a potent chemoattractant for eosinophils | SIGNOR-254356 |
Q7LG56 | P23921 | 1 | binding | up-regulates activity | 0.935 | Taken together, we conclude that UV-induced activation of p53R2 transcription and binding of p53R2 to hRRM1 to form RR holoenzyme are impaired in the p53-mutant cell line PC3. | SIGNOR-259366 |
P01112 | P04049 | 1 | binding | up-regulates | 0.935 | We have examined whether the other two members of the Raf family, A-Raf and B-Raf, are regulated in a similar way to Raf-1. A-Raf behaves like Raf-1, being weakly activated by oncogenic Ras more strongly activated by oncogenic Src, and these signals synergize to give maximal activation. B-Raf by contrast is strongly ac... | SIGNOR-235786 |
P06493 | Q12834 | 1 | phosphorylation | down-regulates activity | 0.935 | Cdk1 phosphorylates Cdc20 to negatively regulate its ability to bind and activate the APC/C. | SIGNOR-279321 |
P49767 | P35916 | 1 | binding | up-regulates | 0.935 | Vegf-c, was isolated as a ligand for the tyrosine kinase vegfr-3 (flt4) | SIGNOR-55205 |
P21583 | P10721 | 1 | binding | up-regulates activity | 0.934 | The most relevant and still unique mast-cell growth factor is SCF, which is the ligand of KIT, a receptor with tyrosine-kinase activity that is expressed on the surface of all human and murine mast cells | SIGNOR-254946 |
P01308 | P06213 | 1 | binding | up-regulates activity | 0.934 | Our previous studies indicated that amino acid residues 240-250 in the cysteine-rich region of the human insulin receptor alpha-subunit constitute a site in which insulin binds. | SIGNOR-23001 |
P31948 | P07900 | 1 | binding | down-regulates activity | 0.934 | Hsp90 chaperone cycle is tightly regulated by another group of proteins referred to as ‘co-chaperones'. Their stability does not depend on Hsp90 function but they interact with distinct Hsp90 conformational states, providing directionality to the Hsp90 cycle. Furthermore, certain co-chaperones, such as HOP and Cdc37p50... | SIGNOR-261411 |
P50591 | O14763 | 1 | binding | up-regulates | 0.934 | Tumour necrosis factor-related apoptosis inducing ligand (trail) receptor 2 (trail-r2) also known as tnfrsf10b (tumour necrosis factor receptor (tnfr) super family 10b) or killer/dr5, a member of the tnfr family, is a promising candidate tumour suppressor gene at 8p21-22. | SIGNOR-134524 |
P50591 | O00220 | 1 | binding | up-regulates | 0.934 | Trail interacts with tril-r1 and trail-r2 and activetes them | SIGNOR-101082 |
O00566 | Q9NQZ2 | 1 | binding | up-regulates activity | 0.934 | Mpp10 is able to bind the ribosome biogenesis factor Utp3/Sas10 through two conserved motifs in its N-terminal region. In addition, Mpp10 interacts with the ribosomal protein S5/uS7 using a short stretch within an acidic loop region. Thus, our findings reveal that Mpp10 provides a platform for the simultaneous interact... | SIGNOR-261176 |
P49815 | Q92574 | 1 | binding | up-regulates activity | 0.934 | Furthermore, tsc2 is directly phosphorylated by akt, which is involved in stimulating cell growth and is activated by growth stimulating signals, such as insulin. Tsc2 is inactivated by akt-dependent phosphorylation, which destabilizes tsc2 and disrupts its interaction with tsc1. | SIGNOR-77400 |
Q9Y4K3 | Q9NYJ8 | 1 | binding | up-regulates activity | 0.933 | The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. | SIGNOR-205458 |
P49366 | P63241 | 1 | post translational modification | up-regulates activity | 0.933 | Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic translation initiation factor 5A (eIF5A). Hypusine is essential for eIF5A activation, which, in turn, plays a key role in regulating protein translation of selected mRNA that are associated ... | SIGNOR-266374 |
O43516 | O00401 | 1 | binding | up-regulates activity | 0.933 | Recruitment of N-WASP to vaccinia is mediated by WASP-interacting protein (WIP), whereas in Shigella WIP is recruited by N-WASP. Our observations show that vaccinia and Shigella activate the Arp2/3 complex to achieve actin-based motility, by mimicking either the SH2/SH3-containing adaptor or Cdc42 signalling pathways t... | SIGNOR-261880 |
P78352 | O14490 | 2 | relocalization | up-regulates activity | 0.932 | Similarly to CASK, PSD95 binds to intracellular adaptor proteins, and especially to GKAP (a protein that binds to the guanylate-kinase domain of PSD95), which, in turn, binds to SHANK proteins (Fig. 1b). | SIGNOR-264196 |
Q8IYD8 | Q9NPI8 | 1 | binding | up-regulates | 0.932 | Protein interaction motifs in fancm, designated mm1 and mm2, were identified. Mm1 interacts with the fa core complex by binding to fancf, whereas mm2 interacts with rm1 and topoisomerase iiialpha, components of the bs complex. | SIGNOR-163101 |
O14490 | P78352 | 2 | binding | up-regulates activity | 0.932 | SAPAPs are specifically expressed in neuronal cells and enriched in the PSD fraction. SAPAPs induce the enrichment of PSD-95/SAP90 to the plasma membrane in transfected cells. Thus, SAPAPs may have a potential activity to maintain the structure of PSD by concentrating its components to the membrane area. | SIGNOR-264209 |
Q13158 | Q14790 | 1 | binding | up-regulates activity | 0.931 | Fadd recruits caspase-8 through homotypic interactions of death-effector domains (deds), leading to caspase-8 activation and apoptosis. In turn, fadd recruits the zymogen form of the apoptosis-initiating protease caspase-8, through homophilic interaction of death effector domains. | SIGNOR-112061 |
P01375 | P20333 | 1 | binding | up-regulates activity | 0.93 | The binding of tnf to tnf-r1 triggers a series of intracellular events that ultimately result in the activation of two major transcription factors, nuclear factor kb (nf-kb) and c-jun. | SIGNOR-88216 |
P30990 | P30989 | 1 | binding | up-regulates | 0.93 | The rat neurotensin receptor cdna sequence was transfected in chinese hamster ovary cells and cellular clones which stably express the corresponding protein were isolated and characterized. The scatchard analysis of the specific binding of [3h]neurotensin indicated a kd value of 0.45 +/- 0.08 nm and a bmax value of 3.2... | SIGNOR-17369 |
O43318 | Q15750 | 2 | phosphorylation | up-regulates activity | 0.929 | We identified amino acids (aa) 452/453 and 456/457 of TAB1 as novel sites phosphorylated by TAK1 as well as by p38 MAPK in intact cells as well as in vitro. | SIGNOR-276365 |
P29965 | P25942 | 1 | binding | up-regulates activity | 0.929 | Ramos cells were mixed with increasing numbers of transfected cells that expressed cd70 (cd27l) or cd154 (cd40l), both of which are expressed by activated T cells, in the presence of anti-igm ab. Cd27 ligation as well as cd40 ligation inhibited bcr-mediated apoptosis in a dose-dependent manner. cd40 binds its ligand cd... | SIGNOR-93432 |
P11802 | P06400 | 1 | phosphorylation | down-regulates | 0.929 | Cyclin d1 is known to activate cdk4, which then phosphorylates the rb protein, leading to cell cycle progression. | SIGNOR-200487 |
O00273 | O76075 | 1 | binding | down-regulates | 0.929 | Dff is a heterodimer of 40 kda and 45 kda subunits. | SIGNOR-29729 |
P42345 | P31749 | 2 | phosphorylation | up-regulates activity | 0.929 | The rictor-mtor complex directly phosphorylated akt/pkb on ser473 in vitro and facilitated thr308 phosphorylation by pdk1 | SIGNOR-252599 |
Q15750 | O43318 | 2 | binding | up-regulates activity | 0.929 | The yeast two-hybrid system has now revealed two human proteins, termed tab1 and tab2 (for tak1 binding protein), that interact with tak1. Overproduction of tab1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by tgf-beta, and increased the kinase activity of tak1. Tab1 acti... | SIGNOR-153031 |
P12643 | P36894 | 1 | binding | up-regulates | 0.929 | BMP interacts with specific receptors on the cell surface, BMP receptor types 1 and 2 (BMPr1 and BMPr2). | SIGNOR-253547 |
O75381 | P50542 | 1 | binding | up-regulates activity | 0.929 | The peroxisomal docking complex is a key component of the import machinery for matrix proteins. The core protein of this complex, Pex14, is thought to represent the initial docking site for the import receptors Pex5 and Pex7. | SIGNOR-253027 |
P31749 | P42345 | 2 | phosphorylation | up-regulates | 0.929 | Once phosphorylated, Akt can act on a broad spectrum of substrates that can influence cell survival and proliferation and protein synthesis (65). Phosphorylation of mTOR by Akt leads to mTOR activation (40, 52) and the subsequent activation of p70S6K | SIGNOR-255107 |
P00797 | P01019 | 2 | cleavage | up-regulates activity | 0.928 | Angiotensinogen, an _-glycoprotein, is released from the liver (152, 250, 444) and is cleaved in the circulation by the enzyme renin that is secreted from the juxtaglomerular apparatus of the kidney (245, 250, 540, 631) to form the decapeptide angiotensin (ANG) I | SIGNOR-252297 |
P01019 | P00797 | 2 | binding | up-regulates activity | 0.928 | Renin is an aspartic protease that enzymatically cleaves its substrate angiotensinogen, which is produced by the liver, to form an inactive peptide: angiotensin (Ang)I or Ang (1–10). | SIGNOR-260224 |
P14210 | P08581 | 1 | binding | up-regulates | 0.928 | Hgf is the ligand for p190met, the receptor tyrosine kinase encoded by the met proto-oncogene. | SIGNOR-38429 |
Q15276 | P20339 | 1 | binding | up-regulates | 0.928 | We have previously shown that rab5, which regulates various steps of transport along the early endocytic pathway, is activated by a complex consisting of rabex-5, a rab5 nucleotide exchange factor, and the effector rabaptin-5. | SIGNOR-109352 |
P62826 | O14980 | 1 | binding | up-regulates activity | 0.928 | The nuclear export by CRM1 requires an interaction with the small GTPase Ras-related nuclear antigen (Ran), which cycles between GTP- and GDP-bound states. The binding of Ran GTP to CRM1 in the nucleus increases the affinity of CRM1 for cargo proteins | SIGNOR-275848 |
P46937 | Q15561 | 1 | binding | up-regulates activity | 0.927 | The multifunctional cytokine TGF-β has been identified as a potent inducer of CTGF expression, activating CTGF transcription through the canonical Smad signaling pathway. It is worth noting that TGF-β synergizes with Hippo–Yes-associated protein (YAP) signaling, a key regulator of tumorigenesis, to induce the expressio... | SIGNOR-277685 |
P60568 | P01589 | 1 | binding | up-regulates | 0.927 | Il-2 is a cytokine that functions as a growth factor and central regulator in the immune system and mediates its effects through ligand-induced hetero-trimerization of the receptor subunits il-2r alpha, il-2r beta, and gamma(c). | SIGNOR-144537 |
Q14242 | P16109 | 1 | binding | up-regulates | 0.927 | The major ligand for p-selectin on leukocytes is p-selectin glycoprotein ligand-1 (PSGL-1) | SIGNOR-47625 |
P42345 | Q13541 | 1 | phosphorylation | down-regulates activity | 0.926 | Specifically as part of mTORC1, mTOR directly phosphorylates the ribo- somal protein S6 kinases (S6K1 and S6K2) and the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BP1 and 4E-BP2), both of which control specific steps in the initiation of cap-dependent translation | SIGNOR-167184 |
P25791 | P17542 | 1 | binding | up-regulates | 0.926 | Transcriptional activity of tal1 in t cell acute lymphoblastic leukemia (t-all) requires rbtn1 or -2 | SIGNOR-46161 |
P01375 | P19438 | 1 | binding | up-regulates activity | 0.925 | For TNFR1, the cytokine TNFα binds to the receptor and triggers its trimerization, which leads to the assembly of the receptor complex and initiation of signaling. | SIGNOR-199091 |
Q13535 | O14757 | 1 | phosphorylation | up-regulates | 0.925 | Atr activation typically leads to chk1 phosphorylation and activation. In response to genotoxic stress, chk1 is phosphorylated on serines 317 (s317) and 345 (s345) by the ataxia-telangiectasia-related (atr) protein kinase. | SIGNOR-134716 |
Q13131 | Q9Y478 | 1 | phosphorylation | up-regulates | 0.925 | Mutation of serine 108 to alanine, an autophosphorylation site within the glycogen binding domain of the beta1 subunit, almost completely abolishes activation of ampk by a-769662 in cells and in vitro, while only partially reducing activation by amp | SIGNOR-157553 |
O95760 | Q01638 | 1 | binding | up-regulates activity | 0.925 | We report a member of the IL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pat... | SIGNOR-277711 |
Q969D9 | Q9HC73 | 1 | binding | up-regulates | 0.924 | Human tslp is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human tslp receptor and the il-7r alpha-chain. | SIGNOR-108920 |
Q16552 | Q96F46 | 1 | binding | up-regulates | 0.924 | Binding studies suggest that recombinant hil-17 binds to the hil-17r with low affinity. Monoclonal antibodies (mabs) generated against the hil-17r were able to block the il-17-induced production of cytokine from human foreskin fibroblast (hff) cells. | SIGNOR-53249 |
O15123 | Q02763 | 1 | binding | up-regulates | 0.924 | Angiopoietin-1 and -2, bound to tek with similar affinities, and angiopoietin-1 effectively induced tek phosphorylation in hematopoietic cells. Angiopoietin-2 also induced a low level of tek phosphorylation and weakened the phosphorylation induced by angiopoietin-1 | SIGNOR-59808 |
O43921 | P54764 | 1 | binding | up-regulates | 0.924 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). I... | SIGNOR-52203 |
Q12824 | P51531 | 1 | binding | up-regulates activity | 0.924 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65181 |
P01112 | P42336 | 1 | binding | up-regulates | 0.924 | In vivo, dominant negative ras mutant n17 inhibits growth factor induced production of 3' phosphorylated phosphoinositides in pc12 cells, and transfection of ras, but not raf, into cos cells results in a large elevation in the level of these lipids. Grb2 binds and activates sos, which then activates ras, and this activ... | SIGNOR-35878 |
P01236 | P16471 | 1 | binding | up-regulates | 0.924 | Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor (prlr). | SIGNOR-72810 |
Q15835 | P08100 | 1 | phosphorylation | up-regulates activity | 0.923 | That light-dependent phosphorylation of Rho is mediated primarily by RK. Addition of an inhibitory antibody against rhodopsin kinase (RK) lowered phosphorylation at Ser334, Ser338, and Ser343, without changing the ratio between phosphorylation sites. upon illumination, Ser334c, Ser338, and Ser343 are phosphorylated. | SIGNOR-251190 |
P00533 | P62993 | 1 | binding | up-regulates activity | 0.923 | Adaptor protein Grb2 binds phosphotyrosines in the epidermal growth factor (EGF) receptor (EGFR) and thereby links receptor activation to intracellular signaling cascades. | SIGNOR-267725 |
Q92585 | P46531 | 1 | binding | up-regulates | 0.923 | Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes1.Maml1 functions as a transcriptional co-activator for notch signalling. | SIGNOR-86117 |
Q96BI3 | P49810 | 1 | binding | up-regulates | 0.923 | Gamma secretase subunit. Leads to ps1/ps2 eterodimer complex stabilisation. By using co-immunoprecipitation and nickel affinity pull-down approaches, we now show that mammalian aph-1 (maph-1), a conserved multipass membrane protein, physically associates with nicastrin and the heterodimers of the presenilin amino- and ... | SIGNOR-93265 |
Q9UJ41 | P20339 | 1 | binding | up-regulates | 0.923 | We have previously shown that rab5, which regulates various steps of transport along the early endocytic pathway, is activated by a complex consisting of rabex-5, a rab5 nucleotide exchange factor, and the effector rabaptin-5. | SIGNOR-109398 |
P12931 | O60716 | 1 | phosphorylation | up-regulates activity | 0.922 | Identification of Src phosphorylation sites in the catenin p120ctn.Using selected tyrosine to phenylalanine p120 mutants as dominant negative reagents, it may now be possible to selectively block events postulated to be dependent on p120 tyrosine phosphorylation.combinations of Tyr _ Phe mutations at residues 96, 112, ... | SIGNOR-246484 |
P98170 | P55211 | 1 | binding | down-regulates quantity by destabilization | 0.922 | A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis | SIGNOR-105702 |
P53350 | P14635 | 1 | phosphorylation | up-regulates activity | 0.922 | Phosphorylation of cyclin b1 is central to its nuclear translocationduring cell-cycle progression in hela cells, a change in the kinase activity of endogenous plk1 toward s147 and/or s133 correlates with a kinase activity in the cell extractsa mutant cyclin b1 in which s133 and s147 are replaced by alanines remains in ... | SIGNOR-105719 |
P52803 | P29317 | 1 | binding | up-regulates | 0.922 | Members of the epha subfamily of receptor tyrosine kinases and their ephrin-a ligands have been implicated in the guidance of retinal axons along the anterior-posterior axis of the chick optic tectum. | SIGNOR-52467 |
O14920 | P25963 | 1 | phosphorylation | down-regulates activity | 0.922 | Tak1 become activated and then phosphorilates and activates ikk2 which in turn now phosphorylates ikba, marking it for k48-ubiquitination and proteasomal degradation | SIGNOR-235400 |
P61764 | Q16623 | 1 | binding | up-regulates activity | 0.922 | Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. | SIGNOR-264042 |
P49815 | Q15382 | 1 | gtpase-activating protein | down-regulates activity | 0.922 | Tsc2 functions as a gap to inhibit rheb activity. Tsc2 displays gap (gtpase-activating protein) activity specifically towards the small g protein rheb and inhibits its ability to stimulate the mtor signaling pathway. It has recently been shown that tsc2 has gtpase-activating protein (gap) activity towards the ras famil... | SIGNOR-128432 |
Q99836 | Q9Y4K3 | 1 | binding | up-regulates activity | 0.922 | In innate immunity, nearly all Toll-like receptors (TLRs), as well as the receptors of the interleukin 1 (IL-1) family of cytokines, initiate signaling by recruiting the adaptor protein MyD88. This is followed by the interaction of IL-1-receptor (IL-R)-associated kinase 4 (IRAK4) with MyD88 and then the interaction of ... | SIGNOR-260160 |
P20701 | P05362 | 1 | binding | up-regulates | 0.922 | This leads to further neutrophil-endothelial cell interactions through the binding of LFA-1 to its endothelial counterreceptor ICAM-1 during the slow rolling phase | SIGNOR-255040 |
P06400 | Q01094 | 1 | binding | down-regulates activity | 0.921 | E2f binds rb. E2f activation domain is the target for rb-induced repression. Rb can silence the 57 residue e2f activation domain. Rb can mask e2f residues involved in the activation process, possibly by mimicking a component of the transcriptional machinery | SIGNOR-37305 |
P23510 | P43489 | 1 | binding | up-regulates | 0.921 | Activation of nf-kappab in ox40-transfected hsb-2 cells was detected by electrophoretic mobility shift assay within 30 min after the binding of the ligand gp34. | SIGNOR-54927 |
P13984 | P19388 | 1 | binding | up-regulates activity | 0.921 | Direct Interaction Between the Subunit RAP30 of Transcription Factor IIF (TFIIF) and RNA Polymerase Subunit 5, Which Contributes to the Association Between TFIIF and RNA Polymerase II. we showed that RPB5 binds RAP30 but not RAP74 and associates to TFIIF through the binding to RAP30. | SIGNOR-261179 |
Q00978 | P52630 | 1 | binding | up-regulates activity | 0.921 | Coimmunoprecipitation assays demonstrate p48 association with STAT2 but not STAT1.The studies demonstrate the in vivo existence of a STAT2.p48 complex and a distinct STAT2.STAT1 complex after IFN-alpha stimulation. Data suggest that distinct bipartite complexes STAT2.p48 and STAT2.STAT1 translocate to the nucleus and a... | SIGNOR-217806 |
Q7L9L4 | O95835 | 1 | binding | up-regulates | 0.921 | Lats1/2 are activated by association with the highly homologous scaffold proteins mps one binder kinase activator-like 1a (mobkl1a) and 1b (mobkl1b), which are collectively referred to as mob1. | SIGNOR-169795 |
O43791 | Q13618 | 1 | binding | up-regulates activity | 0.921 | Here we show that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP binds Geminin at endogenous level and regulates DNA replication. SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at lysine residues 100 and 127. | SIGNOR-268927 |
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