id stringlengths 24 24 | contexts_ids listlengths 1 157 | split stringclasses 1
value | question stringlengths 13 215 | type stringclasses 4
values | answer stringlengths 2 3.15k | exact_answer stringlengths 1 3.15k | contexts listlengths 1 157 | concepts stringlengths 3 7.42k |
|---|---|---|---|---|---|---|---|---|
5c71648b7c78d69471000067 | [
8877308,
10760494
] | train | Can Diazepam be beneficial in the treatment of traumatic brain injury? | yesno | Diazepam treatment improved cognitive recovery and mortality in brain injured rats. | yes | [
"A 34-year-old woman with a severe closed-head injury had many impairments \nincluding apparent global aphasia. After a diazepam premedication for a motor \npoint block she was heard to speak a few words. A trial of oral diazepam \nsucceeded in restoring speech adequate to make her needs known, which persisted \non... | nan |
52b2ec944003448f55000002 | [
19861158,
18208360,
21076489,
15126506,
21114762,
20874444,
19408108,
18193389,
22438832,
15942449,
18371346,
22187289,
20592766,
21431325,
19066462
] | train | Can FOXOs modulate longevity? | yesno | FOXOs are reliable markers of longevity. | yes | [
"GH/insulin/IGF-1 signaling is a vital pathway e.g. in the regulation of protein \nsynthesis and glucose metabolism. However, mouse dwarf strains which exhibit \nreduced GH secretion and subsequently a decline in IGF-1 signaling can live \nlonger than their wild type counterparts. There is striking evidence indicat... | ['http://www.uniprot.org/uniprot/FOXO_DROME', 'http://www.uniprot.org/uniprot/FOXO_DROSE', 'http://www.uniprot.org/uniprot/FOXO_DROPE', 'http://www.uniprot.org/uniprot/FOXO_DROMO', 'http://www.uniprot.org/uniprot/FOXO_CAEEL', 'http://www.uniprot.org/uniprot/FOXO_DROPS', 'http://www.uniprot.org/uniprot/FOXO_DROGR', 'htt... |
60328f351cb411341a000145 | [
32043729,
31721330,
32048253,
31857078
] | train | Can Freund's complete adjuvant induce arthritis? | yesno | Yes, Rheumatoid arthritis (RA) was induced by Freund's Complete Adjuvant (FCA; 1 mg/0.1 ml paraffin oil), injected subcutaneously on days 0, 30 and 40 | yes | [
"BACKGROUND: Rheumatoid arthritis (RA) is associated with joint damage. \nEffectiveness of embelin has been established in a wide variety of inflammatory \ndisorders, but its utility as a therapeutic agent is limited by its poor \nabsorption, rapid metabolism, and fast systemic elimination. To apprehend these \nlim... | nan |
5ad3013d0340b9f058000019 | [
27974345
] | train | Can GDF15 be a biomarker for metformin treatment? | yesno | Yes, GDF15 levels are a biomarker for the use of metformin in people with dysglycemia, and its concentration reflects the dose of metformin. | yes | [
"OBJECTIVE: Metformin is a commonly used glucose-lowering drug. However, apart \nfrom glycemic measures, no biomarker for its presence or dose has been \nidentified.\nRESEARCH DESIGN AND METHODS: A total of 237 biomarkers were assayed in baseline \nserum from 8,401 participants (2,317 receiving metformin) in the Ou... | nan |
6217d9bf3a8413c653000024 | [
22396896,
30050535,
20811799,
23613752,
34819931
] | train | Can IFNg induce the expression of IDO? | yesno | Yes,
IFNG-induce up-regulation of indoleamine 2,3-dioxygenase (IDO) | yes | [
"Aging is associated with the chronic, low grade, Th-1 type inflammation. The key \nTh-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally \ninduces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, \nindoleamine 2,3- dioxygenase (IDO). Activation of IDO shunts TRY m... | nan |
61f93c38882a024a1000004b | [
33460320,
34766657,
33716705,
32227247
] | train | Can Isradipine slow progression of Early Parkinson Disease? | yesno | No. In a multicenter, randomized, parallel-group, double-blind, placebo-controlled trial Isradipine did not slow progression of Early Parkinson Disease. | no | [
"OBJECTIVES: Isradipine is a dihydropyridine calcium channel inhibitor that has \ndemonstrated concentration-dependent neuroprotective effects in animal models of \nParkinson's disease (PD) but failed to show efficacy in a phase 3 clinical \ntrial. The objectives of this study were to model the plasma pharmacokinet... | nan |
5e2a04feaa19d74431000009 | [
28588271
] | train | Can LB-100 downregulate miR-33? | yesno | No, LB-100 has been reported to modulate (upregulate) only miR-181b-1. | no | [
"Author information:\n(1)Department of Hematology, The First Affiliated Hospital, College of Medicine, \nZhejiang University, Hangzhou, 310003, People's Republic of China.\n(2)Department of Hematology, Hangzhou First People's Hospital, Hangzhou, 310006, \nZhejiang Province, People's Republic of China.\n(3)Myelodysp... | nan |
5e29f959aa19d74431000004 | [
25376608
] | train | Can LB-100 sensitize ovarian carcinoma to cisplatin? | yesno | Yes, LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. | yes | [
"Despite early positive response to platinum-based chemotherapy, the majority of \novarian carcinomas develop resistance and progress to fatal disease. Protein \nphosphatase 2A (PP2A) is a ubiquitous phosphatase involved in the regulation of \nDNA-damage response (DDR) and cell-cycle checkpoint pathways. Recent stu... | nan |
52b2ec744003448f55000001 | [
19701833
] | train | Can Levoxyl (levothyroxine sodium) cause insomnia? | yesno | Levoxyl monotherapy is associated with increased insomnia compared to a combination of levothyroxine and liothyronine. | yes | [
"OBJECTIVES: To examine the efficacy of combination therapy with levothyroxine \nand liothyronine in improvement of general health, psychological problems, and \nmetabolic status in primary hypothyroidism.\nMETHODS: Seventy-one patients diagnosed with primary hypothyroidism were \nrandomly allocated into two study ... | ['http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013974', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007319'] |
5a75f1f383b0d9ea66000006 | [
26664519
] | train | Can Logic Alignment Free (LAF) be used for bacterial genomes classification? | yesno | Yes. Logic Alignment Free (LAF), a method that combines alignment-free techniques and rule-based classification algorithms can be used in order to assign biological samples to their taxa. | yes | [
"Alignment-free algorithms can be used to estimate the similarity of biological \nsequences and hence are often applied to the phylogenetic reconstruction of \ngenomes. Most of these algorithms rely on comparing the frequency of all the \ndistinct substrings of fixed length (k-mers) that occur in the analyzed \nseq... | ['https://meshb.nlm.nih.gov/record/ui?ui=D008128', 'https://meshb.nlm.nih.gov/record/ui?ui=D016680', 'https://meshb.nlm.nih.gov/record/ui?ui=D002965'] |
622662e13a8413c653000085 | [
34505967
] | train | Can METTL3 methylate long noncoding RNAs? | yesno | Yes, METTL3 can modulate methylation and expression of lncRNA. | yes | [
"OBJECTIVES: This study aimed to explore the regulatory mechanism of \nmethyltransferase3 (METTL3) -mediated long non-coding RNA (lncRNA) \nN6-methyladenosine (m6A) modification in the osteogenic differentiation of human \nadipose-derived stem cells (hASCs) induced by NEL-like 1 protein (NELL-1).\nMATERIALS AND MET... | nan |
5e776541835f4e4777000009 | [
25726088
] | train | Can MVA85A confer immunity against smallpox? | yesno | No MVA85A is a candidate tuberculosis vaccine. | no | [
"BACKGROUND: HIV-1 infection is associated with increased risk of tuberculosis \nand a safe and effective vaccine would assist control measures. We assessed the \nsafety, immunogenicity, and efficacy of a candidate tuberculosis vaccine, \nmodified vaccinia virus Ankara expressing antigen 85A (MVA85A), in adults \ni... | nan |
58a5924060087bc10a000020 | [
16393992,
16741139,
15845907,
17046555,
25666589,
12424096,
17341601,
24794531,
1324836,
25920934,
22134950,
3800872,
19281832,
19819434,
15308331,
19892012,
21159852,
22503982,
12867501,
21693104,
15271858,
26728380,
24037962,
11755128,
18195159,
23229789,
153466... | train | Can NADPH oxidase be inhibited by apocynin and diphenylene iodonium? | yesno | Yes, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase can be inhibited by apocynin or diphenylene iodonium (DPI). | yes | [
"Microglia are resident brain macrophages that become activated and proliferate \nfollowing brain damage or stimulation by immune mediators, such as IL-1beta or \nTNF-alpha. We investigated the mechanisms by which microglial proliferation is \nregulated in primary cultures of rat glia. We found that basal prolifera... | ['http://amigo.geneontology.org/amigo/term/GO:0016174', 'http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4251947', 'https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019255', 'http://www.biosemantics.org/jochem#4270191', 'http://www.biosemantics.org/jochem#http://... |
54d62faf3706e89528000003 | [
21651461,
22709256,
17579658,
17068304,
11239186,
18369171,
19074479,
18673209,
17420989,
17975102,
12848592,
23419732,
17478741,
16467546,
17687131,
18416999,
19167593,
17408618,
17244778,
23109881,
19631615
] | train | Can NXY-059 be used for treatment of acute ischemic stroke patients? | yesno | No. 2,4-disulfonylphenyl PBN derivative, called NXY-059 in the stroke studies, was shown to be safe in humans and was taken all the way through clinical phase 3 trials and then was deemed to be ineffective. | no | [
"The nitrone compound PBN, α-phenyl-tert-butylnitrone, and closely related \nnitrones have anti-cancer activity in several experimental cancer models. The \nthree experimental models most extensively studied include A) the rat choline \ndeficiency liver cancer model, B) the rat C6 glioma model and C) the mouse \nAP... | nan |
5e2a0eb1aa19d7443100000c | [
31171773
] | train | Can PRL3-zumab inhibit PRL3+ cancer cells in vitro and in vivo? | yesno | PRL3-zumab specifically inhibits PRL3+ cancer cells in vivo, but not in vitro. | no | [
"Author information:\n(1)Institute of Molecular and Cell Biology, Agency for Science, Technology and \nResearch (A*STAR), Singapore, 138673, Singapore.\n(2)Department of Haematology-Oncology, National University Cancer Institute, \nSingapore (NCIS), Singapore, 119082, Singapore.\n(3)Division of Cellular and Molecul... | nan |
601cb7a61cb411341a000026 | [
23010833,
20726623,
33028137
] | train | Can Panitumumab cause trichomegaly? | yesno | Yes. Panitumumab is EGFR inhibitor that is associated with eyelash trichomegaly. | yes | [
"A wide spectrum of skin toxicities has been described in patients receiving \nepidermal growth factor receptor (EGFR), inhibitors, including papulopustular \nrash, xerosis and fissures, pruritus, mucositis, paronychia, and hair \nchanges.Trichomegaly of the eyelashes is a rare adverse effect of EGFR inhibitor \nth... | nan |
5e371a1db5b409ea53000015 | [
29472484,
30629588
] | train | Can Patient-derived organoids (PDOs) recapitulate patient responses in the clinic? | yesno | Yes. Phenotypic and genotypic profiling of PDOs showed a high degree of similarity to the original patient tumors. Molecular profiling of tumor organoids was matched to drug-screening results, suggesting that PDOs could complement existing approaches in defining cancer vulnerabilities and improving treatment responses.... | yes | [
"Author information:\n(1)Division of Molecular Pathology, The Institute of Cancer Research, London, \nUK.\n(2)Centre for Evolution and Cancer, The Institute of Cancer Research, London, \nUK.\n(3)Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and \nImaging, The Institute of Cancer Research and Ro... | nan |
5890eb22621ea6ff7e000006 | [
25001601,
11445697,
22278372,
25591437,
24958171,
23341967,
25048752,
15977234,
21423699,
26872435,
26982005,
26717657,
25227610,
25530683,
27864924,
24039869,
20119647
] | train | Can Pentraxin 3 predict outcomes of sepsis? | yesno | Yes, Pentraxin 3 s an objective biochemical marker in diagnosis of sepsis; it is helpful in assessment of severity and prognosis of sepsis; it also has a certain clinical value in the assessment of sepsis cardiovascular function damage. | yes | [
"Multidrug-resistant Acinetobacter baumannii is among the most prevalent \nbacterial pathogens associated with trauma-related wound and bloodstream \ninfections. Although septic shock and disseminated intravascular coagulation \nhave been reported following fulminant A. baumannii sepsis, little is known \nabout the... | ['https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018805', 'http://www.biosemantics.org/jochem#4264880', 'https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000066891'] |
52b2ed144003448f55000004 | [
19294755,
19891844,
18222917,
12470342,
20638568,
9329835,
19251775,
18829009,
20102489,
18667646,
12615807
] | train | Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection? | yesno | Preimplantation Genetic Diagnosis can be used for gender selection. | yes | [
"OBJECTIVES: To investigate Hong Kong couples' attitudes and concerns about using \npreimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) \ntyping to conceive a disease-free and tissue-compatible 'Saviour Child (SC)' to \nsave an afflicted sibling.\nMETHODS: Two cohorts of Chinese couples, one ... | ['http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012743', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005783', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019836'] |
56ed08062ac5ed1459000005 | [
23808545,
21391905,
22753001,
23084521,
25082860,
23400593,
24869939,
24900694,
24812409,
24309210
] | train | Can RG7112 inhibit MDM2? | yesno | Yes, RG7112 is a small molecule MDM2 antagonist. | yes | [
"Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been \nconsidered an attractive approach for cancer treatment. However, the hydrophobic \nprotein-protein interaction surface represents a significant challenge for the \ndevelopment of small-molecule inhibitors with desirable pharmacologica... | ['http://www.uniprot.org/uniprot/MDM2_DANRE', 'http://www.uniprot.org/uniprot/MDM2_MOUSE', 'http://www.uniprot.org/uniprot/MDM2_MESAU', 'http://www.uniprot.org/uniprot/MDM2_CANLF', 'http://www.uniprot.org/uniprot/MDM2_HUMAN', 'http://www.uniprot.org/uniprot/MDM2_FELCA', 'http://www.uniprot.org/uniprot/MDM2_XENLA'] |
571696d9cb4ef8864c000009 | [
18004386,
15964997,
16624367,
17132145,
17855633,
20943989,
23395899,
15827195
] | train | Can RNAPolII function as an RNA-dependent RNA-polymerase? | yesno | RNA polymerase II (Pol II) is a well-characterized DNA-dependent RNA polymerase, which has also been reported to have RNA-dependent RNA polymerase (RdRP) activity. Pol II can use a homopolymeric RNA template, can extend RNA by several nucleotides in the absence of DNA, and has been implicated in the replication of the ... | yes | [
"RNA polymerase (Pol) II catalyses DNA-dependent RNA synthesis during gene \ntranscription. There is, however, evidence that Pol II also possesses \nRNA-dependent RNA polymerase (RdRP) activity. Pol II can use a homopolymeric RNA \ntemplate, can extend RNA by several nucleotides in the absence of DNA, and has \nbee... | ['http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012319'] |
601c1a271cb411341a000011 | [
32499606
] | train | Can SMAD6 variants cause craniosynostosis? | yesno | Yes, SMAD6 variants can cause craniosynostosis. | yes | [
"Author information:\n(1)MRC Weatherall Institute of Molecular Medicine, University of Oxford, John \nRadcliffe Hospital, Oxford, UK.\n(2)Department of Pediatrics, University of California-Davis, Sacramento, CA, \nUSA.\n(3)Departments of Pathology and Bioinformatics, Erasmus MC, University Medical \nCenter Rotterda... | nan |
56cc947b5795f9a73e000033 | [
10995744,
24290762,
21900893,
23510938
] | train | Can SUMO affect calcium homeostasis? | yesno | Yes, SUMO proteins can affect calcium homeostasis. | yes | [
"Drosophila Uba2 and Ubc9 SUMO-1 conjugation enzyme homologs (DmUba2 and DmUbc9) \nwere isolated as calcium/calmodulin-dependent kinase II (CaMKII) interacting \nproteins by yeast two-hybrid screening of an adult head cDNA library. We found \nthat at least one isoform of Drosophila neuronal CaMKII is conjugated to ... | ['http://amigo.geneontology.org/amigo/term/GO:0055074', 'http://www.uniprot.org/uniprot/SUMO_CAEEL'] |
5e4c06d96d0a27794100002e | [
18813701,
22492779,
29208845,
29103182,
15985581,
28387089,
15557494,
17875548
] | train | Can Systemic Lupus Erythematosus cause seizures? | yesno | In the extant literature, an increased risk of seizures has been described in several inflammatory/autoimmune disorders, including systemic lupus erythematosus (SLE) | yes | [
"INTRODUCTION: Juvenile systemic lupus erythematosus is more incident in female \naffecting different systems including the central nervous system. The aim of \nthis study was to check the incidence of seizures and electroencephalographic \nfeatures in these patients.\nMETHOD: It was analyzed all patients with juve... | nan |
5ca61176ecadf2e73f00004e | [
26862051,
22495304,
30374058,
29990539,
30241613,
28408976,
27111891,
30086749,
25959774
] | train | Can TAD disruption lead to disease? | yesno | TAD boundaries are insulators of genomic neighborhoods. Τhe disruption of these structures by genomic rearrangements can result in gene misexpression and disease. | yes | [
"Author information:\n(1)Max Planck Institute for Molecular Genetics, RG Development and Disease, \n14195 Berlin, Germany; Institute for Medical and Human Genetics, Charité - \nUniversitätsmedizin Berlin, 13353 Berlin, Germany; Berlin-Brandenburg Center for \nRegenerative Therapies (BCRT), Charité - Universitätsmed... | nan |
5a895a96fcd1d6a10c000003 | [
27892769,
29028266,
27255916,
26649774,
28344080,
26874353,
28344082,
27617908,
28903484,
27612318
] | train | Can a circRNA be translated into protein? | summary | Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes.
Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of ... | Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes.
Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have recently emerged as regulators of ... | [
"Circular RNAs (circRNAs) are highly abundant and evolutionarily conserved \nnon-coding RNAs produced by circularization of specific exons. Since their \nre-discovery as potential regulators of gene expression, thousands of circRNAs \nwere detected in different tissues and cell types across most organisms. \nAccumu... | nan |
53443b13aeec6fbd0700000e | [
10439043,
21296653,
24130701,
19150354,
20842131,
20191379,
17917077,
12123800,
16581027,
22714536,
22533554,
19389625,
16139842,
16815302,
18195017,
22811618,
22956136,
18186614,
24188027
] | train | Can a peptide aptamer be used as protein inhibitor? | yesno | Yes, peptide aptamers can be used as inhibitors. | yes | [
"The p16-cyclin D-pRB-E2F pathway is frequently deregulated in human tumors. This \ncritical regulatory pathway controls the G1/S transition of the mammalian cell \ncycle by positive and negative regulation of E2F-responsive genes required for \nDNA replication. To assess the value of the transcription factors E2Fs... | ['http://www.uniprot.org/uniprot/INH_BPT4', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D010455', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011500', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D052158'] |
5890e762621ea6ff7e000005 | [
8456713,
21082060,
21289580,
27651774,
24094991,
25459742
] | train | Can acupuncture cause spinal epidural hematoma? | yesno | Yes, acupuncture can cause spinal epidural hematoma. | yes | [
"Unintentional acupuncture needling of the thoracic spinal canal produced a \nspinal epidural hematoma and subarachnoid hemorrhage. This case demonstrates \nthat patients are sometimes reluctant to disclose folk medical treatments to \nWestern physicians, and the proper diagnosis may depend upon the prowess of the ... | ['https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D046748', 'https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D026881'] |
5314d0e4dae131f84700000e | [
19761698,
23387883,
21947558
] | train | Can administration of the thyrotropin releasing hormone reduce fatigue in cancer patients? | yesno | yes, in cancer patients, thyrotropin releasing hormone (TRH) administration was associated with significant improvement in cancer related fatigue levels as measured by the Visual Analog Scale-Energy, fatigue and vigor subscales of the POMS, and the fatigue subscale of FACIT-F. TRH administration was safe and tolerable ... | yes | [
"Fatigue in cancer patients is highly prevalent, predominantly idiopathic, \ndifficult to manage, and has a significant negative impact on quality of life. \nThyrotropin-releasing hormone (TRH) exerts normotrophic, state-dependent \ntherapeutic effects in a variety of experimental and clinical situations. To \neval... | ['http://www.uniprot.org/uniprot/TRH_NOTVI', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013973', 'http://www.uniprot.org/uniprot/TRHA_XENLA', 'http://www.uniprot.org/uniprot/TRH_BOMOR', 'http://www.disease-ontology.org/api/metadata/DOID:162', 'http://www.uniprot.org/uniprot/TRH_P... |
531481ade3eabad021000016 | [
24222332,
11929793,
7541126,
14594506,
10908330,
16939628,
16735596,
17456718,
23997901,
17486495,
22460946,
17041717,
10575541,
21415990,
11144280,
20305142,
20201948,
18379999
] | train | Can adult humans be induced to produce fetal hemoglobin? | yesno | Fetal hemoglobin, or foetal haemoglobin, is the main oxygen transport protein in the human fetus during the last seven months of development in the uterus and in the newborn until roughly 6 months old. Functionally, fetal hemoglobin differs most from adult hemoglobin in that it is able to bind oxygen with greater affi... | yes | [
"Fetal hemoglobin (HbF) modulates the phenotype of sickle cell anemia by \ninhibiting deoxy sickle hemoglobin (HbS) polymerization. The blood concentration \nof HbF, or the number of cells with detectable HbF (F-cells), does not measure \nthe amount of HbF/F-cell. Even patients with high HbF can have severe disease... | ['http://www.biosemantics.org/jochem#4249367', 'http://www.uniprot.org/uniprot/GLB_APLLI', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006454', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055545', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?... |
5c900779ecadf2e73f000001 | [
22726826
] | train | Can antisense threapy be used for Huntington's disease? | yesno | Yes, antisense oligonucleotide therapy has been shown to lower Huntingtin mRNA levels and be beneficial against Huntington's disease. | yes | [
"Lowering mutant Huntingtin is a consensus therapeutic strategy for Huntington's \ndisease. In this issue of Neuron, Kordasiewicz et al. (2012) show the benefit of \ntransient antisense oligonucleotide (ASO) therapy to degrade Huntingtin mRNA and \nelicit sustained therapeutic benefit in HD mice."
] | nan |
58efa66070f9fc6f0f000005 | [
27289249,
27817122,
26940135,
27543497,
26926089,
27268656,
26510933,
26712086,
26433247
] | train | Can aspirin be used in cancer prevention? | summary | Long-term aspirin use was associated with a modest but significantly reduced risk for overall cancer, especially gastrointestinal tract tumors. Regular aspirin use may prevent a substantial proportion of colorectal cancers and complement the benefits of screening. | Long-term aspirin use was associated with a modest but significantly reduced risk for overall cancer, especially gastrointestinal tract tumors. Regular aspirin use may prevent a substantial proportion of colorectal cancers and complement the benefits of screening. | [
"Considerable interest has emerged over the last decade regarding the role of \naspirin in prevention of colorectal cancer. This disease is one of the commonest \ncancers in the Western World, therefore, the existence of a simple \"everyday\" \nagent, which could have the ability to prevent the disease, represents ... | nan |
62266c353a8413c65300008a | [
34692467
] | train | Can autophagy related lncRNAs be used for colorectal cancer prognosis? | yesno | Yes, a prognostic prediction model of CRC was built based on nine ARlncRNAs (NKILA, LINC00174, AC008760.1, LINC02041, PCAT6, AC156455.1, LINC01503, LINC00957, and CD27-AS1). The 5-year overall survival rate was significantly lower in the high-risk group than in the low-risk group among train set, validation set, and al... | yes | [
"INTRODUCTION: Colorectal cancer (CRC) is the most common gastrointestinal cancer \nand has a low overall survival rate. Tumor-node-metastasis staging alone is \ninsufficient to predict patient prognosis. Autophagy and long noncoding RNAs \nplay important roles in regulating the biological behavior of CRC. Therefor... | nan |
58bca1c202b8c6095300000b | [
22524832,
26769089,
15527074,
22916808,
25997867,
15302513,
26290674,
23194196,
19723093,
23027830,
23394551,
24952025
] | train | Can beans induce apoptosis? | yesno | White kidney bean lectin has been shown to exert anti-proliferative and apoptotic effects on cancer cells | yes | [
"Non-toxic stimulation of dendritic cells (DCs), which are central \nimmunomodulators, may aid the prevention of cancer. Furthermore, induction of \napoptosis in cancer cells by anticancer agents contributes to the induction of \nDC maturation. We previously reported that extracts from Pinus parviflora Sieb. \net Z... | ['https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D017209'] |
620588f9c9dfcb9c09000033 | [
34347307
] | train | Can bergapten cause phototoxicity? | yesno | Yes, phototoxicity is a side effect of bergapten. | yes | [
"Bergapten is a natural furocoumarin, also known as 5-methoxypsoralen, and its \nmedicinal value has been paid more and more attention. By sorting out the \npharmacological literature of bergapten, we found that bergapten has a wide \nrange of pharmacological effects, including neuroprotection, organ protection, \n... | nan |
620586a8c9dfcb9c09000032 | [
34347307
] | train | Can bergapten cross the blood-brain barrier? | yesno | Yes, bergapten can cross the blood-brain barrier. | yes | [
"Bergapten is a natural furocoumarin, also known as 5-methoxypsoralen, and its \nmedicinal value has been paid more and more attention. By sorting out the \npharmacological literature of bergapten, we found that bergapten has a wide \nrange of pharmacological effects, including neuroprotection, organ protection, \n... | nan |
571394141174fb175500000b | [
24887553,
21527813,
25130390,
23260439,
25242654,
22394017,
24903714,
24998183,
24758832,
25457969,
21504055,
22436025,
24334142,
22767299,
24695367,
23411530,
23184715,
20546891,
25047630,
23719889,
22508498,
24961492,
21358040,
23380571,
24188635,
25048797,
2035... | train | Can bioprinting use human cells? | yesno | Yes, human cells can be used for bioprinting | yes | [
"Author information:\n(1)1] Department of Mechanical Engineering, Pohang University of Science and \nTechnology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784, South \nKorea [2].\n(2)1] Division of Integrative Biosciences and Biotechnology, Pohang University \nof Science and Technology (POSTECH), 77 Ch... | ['http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D062028', 'http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006801', 'http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002477'] |
554763f0f35db75526000002 | [
23735780,
24235190
] | train | Can botulism poisoning of a pregnant woman harm her fetus? | yesno | Botulinum toxin, which causes botulism, is not expected to be present in systemic circulation following proper intramuscular or intradermal injection. Moreover, botulinum toxin has a high molecular weight, and does not appear to cross the placenta. Based on the study cases reported in the literature, botulism poisoning... | no | [
"During 1985-2005, a total of 91 laboratory-confirmed outbreaks of foodborne \nbotulism occurred in Canada; these outbreaks involved 205 cases and 11 deaths. \nOf the outbreaks, 75 (86.2%) were caused by Clostridium botulinum type E, \nfollowed by types A (7, 8.1%) and B (5, 5.7%). Approximately 85% of the \noutbre... | ['http://www.disease-ontology.org/api/metadata/DOID:11976', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005333', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014930', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term... |
5be44f50133db5eb78000017 | [
21348815
] | train | Can breastfeeding confer protection from type I diabetes? | yesno | In the neonate and infant lactation confers protection from future type 1 diabetes. | yes | [
"The present review outlines the role of breastfeeding in diabetes. In the \nmother, breastfeeding has been suggested to reduce the incidence of type 2 \ndiabetes mellitus, the metabolic syndrome and cardiovascular disease. Moreover, \nit appears to reduce the risk of premenopausal breast cancer and ovarian cancer.... | nan |
57135fae1174fb1755000004 | [
23581568,
22937795,
24603453,
18234572,
24352524,
21207386,
24204719,
23690098,
22863603,
24834709,
24482806,
22720727,
23024794,
20840219,
22261468,
22192861,
15859391
] | train | Can cffDNA be used for non-invasive testing? | yesno | Yes, cell-free fetal DNA (cffDNA) has made non-invasive prenatal testing possible. | yes | [
"OBJECTIVE: The aim of this study is to prevent false positive results in \nnon-invasive foetal sex determination from pregnant women's plasma following \nstrict anti-contamination criteria.\nMETHODS: cffDNA from 200 pregnant women (mean gestational age of 8.3 ± 0.2 \nweeks) was analyzed based on genetic forensic a... | nan |
56d34fbcf22319765a000009 | [
18378481,
23167566
] | train | Can chronological age be predicted by measuring telomere length? | yesno | No, telomere length measurement by real-time quantitative PCR cannot be used to predict age of a person, due to the presence of large inter-individual variations in telomere lengths. | no | [
"Currently DNA profiling methods only compare a suspect's DNA with DNA left at \nthe crime scene. When there is no suspect, it would be useful for the police to \nbe able to predict what the person of interest looks like by analysing the DNA \nleft behind in a crime scene. Determination of the age of the suspect is... | nan |
515df89e298dcd4e5100002f | [
14977793,
18095969,
21150631,
17416907,
12173195,
23394604,
16632814,
16301230,
17986032,
16677266,
17019218,
20514964,
11473855
] | train | Can clonidine be used to reduce agitation in children. | yesno | Yes, clonidine is effective in prevention of post-anesthesia agitation in children. | yes | [
"BACKGROUND: This double-blind randomized study was undertaken to assess \nagitation, Bispectral Index (BIS) and EEG changes during induction of \nanaesthesia with sevoflurane in children premedicated with midazolam or \nclonidine.\nMETHODS: Children were allocated randomly to receive rectal midazolam 0.4 mg \nkg(-... | ['http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011595', 'http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002648', 'http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003000'] |
54d762653706e89528000014 | [
25083010,
20651011,
24971014,
22926087,
21372697,
20890148,
18310181,
24419112,
20930100,
19450037,
25299140,
18246853,
23557323,
24650832,
25150812,
19090531,
24458595,
19900778,
20656618,
25233905,
21538678,
23707383,
17050873
] | train | Can cognitive behavioral therapy improve fatigue in cancer patients? | yesno | Yes, it has been documented that cognitive behavioral therapy reduces fatigue symptom severity in cancer patients. In addition, cognitive behavioral therapy has been also shown to improve mood and overall quality of life, and it can be successfully delivered through a variety of treatment modalities in patients with c... | yes | [
"STUDY OBJECTIVE: To assess the short-term efficacy of a video-based cognitive \nbehavioral therapy for insomnia (CBT-I) as compared to a professionally \nadministered CBT-I and to a no-treatment group.\nDESIGN: Randomized controlled trial.\nSETTING: Radio-oncology department of a public hospital affiliated with \n... | nan |
530cf4fe960c95ad0c00000c | [
20107296,
23881185,
22173281,
21067460,
23473348,
23517291,
23587982,
19407730,
18507895,
19407711
] | train | Can desvenlafaxine be used at a dose of 50mg/day? | yesno | Yes, desvenlafaxine can be at 50mg/day to treat patients with major depressive disorder. Studies suggest that 50 mg is the minimum effective dose of desvenlafaxine for the treatment of major depressive disorder. The recommended dose of DVS ranges from 50 to 100 mg. | yes | [
"Desvenlafaxine succinate (DVS) is one of several serotonin-norepinephrine \nreuptake inhibitors (SNRIs). Others are venlafaxine hydrochloride, milnacipran, \nand duloxetine. Desvenlafaxine has been approved by the US Food and Drug \nAdministration (FDA) for the treatment of major depressive disorder (MDD) based \n... | ['http://www.biosemantics.org/jochem#4266016', 'http://www.biosemantics.org/jochem#4243854'] |
5e2b0d71fbd6abf43b000001 | [
29788192,
31327649,
26305296,
25106801,
24717404
] | train | Can discharge destinations be accurately predicted using the Risk Assessment and Prediction Tool (RAPT)? | yesno | Yes. The Risk Assessment and Prediction Tool (RAPT) appears to be a valuable predictor of discharge destination after orthopedic surgery and neurosurgical procedures. | yes | [
"BACKGROUND: Bundled care payments are increasingly being explored for \nneurosurgical interventions. In this setting, skilled nursing facility (SNF) is \nless desirable from a cost perspective than discharge to home, underscoring the \nneed for better preoperative prediction of postoperative disposition.\nOBJECTIV... | nan |
5a69031bb750ff445500001e | [
17160610,
10233667,
15262663,
17315050,
23182067,
26299894,
28291967,
26189561,
29083100,
26816569
] | train | Can doxycycline cause photosensitivity? | yesno | Yes, one of the most important dermatologic side effects of doxycycline is photosensitivity. Clinical symptoms vary from light sunburn-like sensation (burning, erythema) to large-area photodermatitis. | yes | [
"BACKGROUND: Therapeutic guidelines for treatment of late manifestations of Lyme \nborreliosis have not yet become well established. Patients with symptoms \nsuggesting central nervous system involvement are often treated with courses of \nintravenous ceftriaxone. This is an expensive treatment approach with \npote... | ['http://www.biosemantics.org/jochem#4069681', 'http://www.biosemantics.org/jochem#4272840', 'https://meshb.nlm.nih.gov/record/ui?ui=D004318'] |
5c6587d77c78d69471000005 | [
29770715
] | train | Can enasidenib be used for the treatment of acute myeloid leukemia? | yesno | Yes, enasidenib has been approved for the treatment of adults with relapsed and refracctory acture myelogenous leukemia with an IDH2 mutation. | yes | [
"In August 2017, the United States Federal Drug Administration (FDA) approved \nenasidenib (Idhifa, Celgene/Agios) for adults with relapsed and refractory acute \nmyelogenous leukemia (AML) with an IDH2 mutation. Enasidenib targets cells with \nmutant copies of isocitrate dehydrogenase-2 (IDH2), inhibiting the \non... | nan |
626aaaa8e764a5320400003a | [
32868918
] | train | Can epigenetic modifications be heritable? | yesno | Epigenetic alterations (epimutations) could thus contribute to heritable variation within populations and be subject to evolutionary processes such as natural selection and drift. | yes | [
"Epigenetic regulation involves changes in gene expression independent of DNA \nsequence variation that are inherited through cell division. In addition to a \nfundamental role in cell differentiation, some epigenetic changes can also be \ntransmitted transgenerationally through meiosis. Epigenetic alterations \n(e... | nan |
550895c12e93f0133a000002 | [
24205503,
24060994,
24196483,
24069349,
23585095,
24250247,
24058411,
24044569,
24101370,
24315007
] | train | Can exosomes be detected in urine? | yesno | Yes, urinary exosomes can be detected in urine. | yes | [
"Exosomes are small (30-150 nm) vesicles containing unique RNA and protein cargo, \nsecreted by all cell types in culture. They are also found in abundance in body \nfluids including blood, saliva, and urine. At the moment, the mechanism of \nexosome formation, the makeup of the cargo, biological pathways, and resu... | ['http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014556', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055354'] |
5c571f7607647bbc4b000017 | [
30515690,
29053963
] | train | Can exposure to heavy metals like lead(Pb) or cadmium(Cd) cause changes in DNA methylation patterns in Isoetes sinensis? | yesno | Changes in DNA methylation of the endangered plant, Isoetes sinensis, have be shown to be affected by both Pb and Cd | yes | [
"To investigate the molecular response of ancient plants to heavy metal stress \nand to explore the feature of DNA methylation in endangered plants after \nexposure to heavy metals, the Isoetes sinensis, an endangered plant, was \nstressed with three different concentrations of two heavy metals lead (Pb) and \ncadm... | nan |
530cf4fe960c95ad0c00000d | [
18371137,
20648930,
22179489,
22023204,
21479141,
21340038,
23889159,
23078888,
24081613,
21699794,
19787830,
23644823,
24114623
] | train | Can ferric carboxymaltose be used to treat anemia in inflammatory bowel disease patients? | yesno | Ferric carboxymaltose can be used to treat anemia in patients with inflammatory bowel disease, and prevents recurrence of anemia in these patients, compared with placebo. Treatment with ferric carboxymaltose is efficious, safe and well tolerated in iron-deficient IBD patients. | yes | [
"BACKGROUND AIMS: Anemia is a common complication of inflammatory bowel diseases \n(IBD) This multicenter study tested the noninferiority and safety of a new \nintravenous iron preparation, ferric carboxymaltose (FeCarb), in comparison with \noral ferrous sulfate (FeSulf) in reducing iron deficiency anemia (IDA) in... | ['http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D003093', 'http://www.disease-ontology.org/api/metadata/DOID:2355', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005290', 'http://www.disease-ontology.org/api/metadata/DOID:0050589', 'http://www.nlm.... |
5a9d30241d1251d03b00001b | [
27351374
] | train | Can gas vesicles be detected by ultrasound? | yesno | Gas vesicles have been identified as nanoscale reporters for ultrasound. | yes | [
"Ultrasound is among the most widely used biomedical imaging modalities, but has \nlimited ability to image specific molecular targets due to the lack of suitable \nnanoscale contrast agents. Gas vesicles-genetically encoded protein \nnanostructures isolated from buoyant photosynthetic microbes-have recently been \... | nan |
5be94b87133db5eb78000020 | [
28165476
] | train | Can gene therapy restore auditory function? | yesno | Yes, gene therapy can restore auditory function. | yes | [
"Because there are currently no biological treatments for hearing loss, we sought \nto advance gene therapy approaches to treat genetic deafness. We focused on \nUsher syndrome, a devastating genetic disorder that causes blindness, balance \ndisorders and profound deafness, and studied a knock-in mouse model, Ush1c... | nan |
588482f5e56acf517600000a | [
24552576,
23633925,
24193798,
26268138,
24072459,
26463916,
17673715,
25422710,
24671831
] | train | Can glyburide reduce cerebral edema? | yesno | Yes. Glyburide, a selective inhibitor of sulfonylurea receptor 1-transient receptor potential melastatin 4, is effective in preventing and attenuating cerebral edema. | yes | [
"Metastatic disease to the brain results in significant morbidity because of \nedema in the central nervous system. Current anti-edema therapies are either \nexpensive or result in unwanted long-term side effects. Sulfonylurea receptor 1 \n(Sur1) is a transmembrane protein that, when activated in the central nervou... | ['https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D001929', 'http://www.biosemantics.org/jochem#4275786', 'http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4275786', 'http://www.disease-ontology.org/api/metadata/DOID:4724', 'https://www.nlm.nih.gov/cgi/mesh/2017/M... |
52f88a972059c6d71c000033 | [
23185200,
23105513,
21150342,
19031760
] | train | Can life style changes reduce oxidative stress | yesno | Our results suggested that life style changes which related to migration might reduce DNA damage in Hasake nationalities. | yes | [
"INTRODUCTION: Chronic fatigue syndrome (CFS) is a widely recognized problem, \ncharacterized by prolonged, debilitating fatigue and a characteristic group of \naccompanying symptoms, that occurs four times more frequently in women than in \nmen. The aim of the study was to determine the existence of oxidative stre... | ['http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D008019', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018384'] |
58d8d0cc8acda34529000008 | [
2629632,
12673793,
16629766,
10679944,
14656017,
10923034,
22521626,
23095199,
27130656,
17457696,
23533858,
9781030,
17349292,
21626167,
9453374,
8124871,
20236116,
20532821,
10980581,
24461181,
11592438,
9490685,
11181567
] | train | Can methylenetetrahydrofolate reductase (MTHFR) gene mutations cause homocystinuria? | yesno | Yes, several methylenetetrahydrofolate reductase (MTHFR) gene mutations can cause homocystinuria and hyperhomocysteinemia. | yes | [
"A 24 day old girl with homocystinuria and hypomethioninaemia caused by \nmethylenetetrahydrofolate reductase deficiency presented with rapidly \nprogressing encephalopathy and myopathy. An almost complete recovery was \nachieved by treatment with betaine.",
"Methylenetetrahydrofolate reductase (MTHFR) synthesize... | ['http://www.uniprot.org/uniprot/MTHR_MOUSE', 'https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006712', 'http://www.uniprot.org/uniprot/MTHR_BOVIN', 'http://www.disease-ontology.org/api/metadata/DOID:9263', 'http://www.uniprot.org/uniprot/MTHR_MACFA', 'https://www.nlm.nih.gov/cgi/mesh... |
5c6583117c78d69471000002 | [
29487059
] | train | Can midostaurin inhibit angiogenesis? | yesno | Yes, midostaurin can inhibit angiogenesis through the inhibition of ithe vascular endothelial growth factor receptor. | yes | [
"Midostaurin was a prototype kinase inhibitor, originally developed as a protein \nkinase C inhibitor and subsequently as an angiogenesis inhibitor, based on its \ninhibition of vascular endothelial growth factor receptor. Despite promising \npreclinical data, early clinical trials in multiple diseases showed only ... | nan |
5c9e766becadf2e73f000038 | [
29335691,
29362447
] | train | Can mitochondria pass through membrane nanotubes? | yesno | Yes,
Membrane nanotubes (MNTs) act as "highways" between cells to facilitate the transfer of multiple signals and play an important role in many diseases. Our previous work reported on the transfer of mitochondria via MNTs between cardiomyocytes (CMs) and cardiac myofibroblasts (MFs). | yes | [
"Membrane nanotubes play important functional roles in numerous cell activities \nsuch as cellular transport and communication. By exerting an external pulling \nforce over a finite region in a membrane patch, here we investigate the size \ndependence of the membrane nanotube formation under the continuum and atomi... | nan |
5c9e738decadf2e73f000037 | [
29158129,
29357914
] | train | Can mitochondria transfer from cell to cell? | yesno | Yes,
the recently discovered phenomenon of mitochondrial transfer between mammalian cells has gained momentum since it was first described in cell culture systems more than a decade ago. | yes | [
"Interest in the recently discovered phenomenon of mitochondrial transfer between \nmammalian cells has gained momentum since it was first described in cell culture \nsystems more than a decade ago. Mitochondria-targeting fluorescent dyes have \nbeen repurposed and are now widely used in these studies and in acute ... | nan |
5c65484ee842deac6700001f | [
29298770
] | train | Can mogamulizumab be used for the treatment of cutaneous T-cell lymphoma? | yesno | Yes, mogamulizumab can be used for the treatment of cutaneous T-cell lymphoma. | yes | [
"In the large international phase III MAVORIC trial, patients with previously \ntreated cutaneous T-cell lymphoma who received the anti-CCR4 monoclonal antibody \nmogamulizumab experienced significantly longer progression-free survival and \nhigher response rates, as well as better quality of life, than those who \... | nan |
5a6f829eb750ff4455000054 | [
2385441,
29159010,
7699907,
9046114,
28116769,
26181153,
25778852,
26623375,
27079282,
28983379,
25383860,
29136724,
6155195,
28550239
] | train | Can multiple myeloma patients develop hyperviscosity syndrome? | yesno | Yes, multiple myeloma patients can develop hyperviscosity syndrome. Multiple myeloma is a neoplastic plasma-cell disorder resulting from malignant plasma cells in the bone marrow. It can cause a hyperviscosity syndrome secondary to the paraproteinaemia associated with the disease. The increased hyperviscosity can lead ... | yes | [
"A case of IgA (kappa type) myeloma complicated by fractures of the bones and \nhyperviscosity syndrome is presented. A 56-year-old woman who had been followed \nas an outpatient with diabetes mellitus for about 16 years, developed multiple \nmyeloma. She also showed symptoms and signs of hyperviscosity syndrome; \... | ['https://meshb.nlm.nih.gov/record/ui?ui=D009101', 'http://www.disease-ontology.org/api/metadata/DOID:9538'] |
5a992eac1d1251d03b00000c | [
27503909
] | train | Can non ubiquitinated Tomm20 promote mitophagy? | yesno | The translocase of outer mitochondrial membrane 20 (Tomm20), is a mitochondrial translocase that, when ubiquitinated, promotes mitophagy. | no | [
"Fbxo7 is a clinically relevant F-box protein, associated with both cancer and \nParkinson's disease (PD). Additionally, SNPs within FBXO7 are correlated with \nalterations in red blood cell parameters. Point mutations within FBXO7 map \nwithin specific functional domains, including near its F-box domain and its \n... | nan |
5c890c3375a4a5d21900000e | [
29571746
] | train | Can oleuropein aglycone interfere with amyloid aggregation? | yesno | Yes, oleuropein aglycone interferes in vitro and in vivo with amyloid aggregates. | yes | [
"Author information:\n(1)Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', \nUniversity of Florence, Viale Morgagni, 50 50134 Florence, Italy; Department of \nNeuroscience, Psychology, Area of Medicine and Health of the Child of the \nUniversity of Florence, Viale Pieraccini, 6, 50139 Flor... | nan |
622f6ad13a8413c6530000aa | [
34703270,
26840774,
28614408,
31496071,
18654798,
17042799,
34169075,
18824533,
34358648
] | train | Can parasite infections by Schistosoma japonicum prevent or improve asthma? | yesno | A peptide named as SJMHE1 from Schistosoma japonicum can suppress asthma in mice. | yes | [
"PURPOSE: Helminths and their products can regulate immune response and offer new \nstrategies to control and alleviate inflammation, including asthma. We \npreviously found that a peptide named as SJMHE1 from Schistosoma japonicum can \nsuppress asthma in mice. This study mainly investigated the molecular mechanis... | nan |
5c72bd047c78d69471000077 | [
26497655,
29396065,
30236511,
22374327
] | train | Can pazopanib be used for treatment von Hippel-Lindau disease? | yesno | Yes, pazopanib is used for treatment von Hippel-Lindau disease. | yes | [
"Hemangioblastoma is a rare benign neoplasm, accounting for less than 2% of all \nprimitive brain tumors. It may arise sporadically in a solitary form, or \nassociated with Von Hippel-Lindau (VHL) disease with multiple tumors. Surgery is \nthe mainstay treatment, but management is challenging in case of recurrent \... | nan |
5be47bff133db5eb78000018 | [
28381231
] | train | Can pets affect infant microbiomed? | yesno | Yes, exposure to household furry pets influences the gut microbiota of infants. | yes | [
"BACKGROUND: Early-life exposure to household pets has the capacity to reduce \nrisk for overweight and allergic disease, especially following caesarean \ndelivery. Since there is some evidence that pets also alter the gut microbial \ncomposition of infants, changes to the gut microbiome are putative pathways by \n... | nan |
5c915e51ecadf2e73f00000c | [
22045904
] | train | Can prevnar 13 be used in children? | yesno | Yes, PCV13 is approved for routine vaccination of all infants as a 4-dose series at age 2, 4, 6, and 12-15 months for children who previously received 1 or more doses of the 7-valent pneumococcal conjugate vaccine (PCV7), and for children with underlying medical conditions that increase their risk for pneumococcal dise... | yes | [
"OBJECTIVE: To review the immunogenicity, efficacy, and safety of the 13-valent \npneumococcal conjugate vaccine (PCV13) for use in pediatric patients.\nDATA SOURCES: A MEDLINE search (2000-September 2011) was conducted using the key \nwords Streptococcus pneumoniae and pneumococcal conjugate vaccine for clinical \... | nan |
601c3f041cb411341a000018 | [
30809505,
23326690,
14738690,
27871556,
25394533,
7851359,
26673613,
30625744,
28733841,
10999506,
31094132,
28396792,
17484185,
21083675,
25332856,
27900925,
28543518,
21623455
] | train | Can propofol cause green urine? | yesno | Yes, propofol can cause green discoloration of urine. It is a rare and benign condition, which occurs when clearance of propofol exceeds the hepatic and extrahepatic elimination. | yes | [
"Propofol is commonly used for induction and maintenance of anesthesia, and \nsedation in the intensive care unit. In addition, it is also used as an \nanesthetic coma treatment for refractory status epilepticus. We present the case \nof a 52-year-old man, who developed green urine following propofol coma therapy \... | nan |
51763a278ed59a060a000030 | [
15099521,
19393186,
18047649,
19324900,
12764196,
23374342,
16027113,
23303787,
17594509,
21282640,
21188497,
20803091,
18332115,
15901843,
15328599,
17204284,
20532223
] | train | Can protein coding exons originate from ALU sequences? | yesno | Yes. Intronic ALUs can evolve into exons by the activation of splice signals residing within the ALU sequence. While most ALU exons do not add or modify the coding capacity of the resulting transcript, examples have been identified of ALU exons becoming protein coding. | yes | [
"Alu exonization, which is an evolutionary pathway that creates primate-specific \ntranscriptomic diversity, is a powerful tool for studying alternative-splicing \nregulation. Through bioinformatic analyses combined with experimental \nmethodology, we identified the mutational changes needed to create functional 5'... | ['http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020087', 'http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005091'] |
601c44ab1cb411341a00001c | [
28868186,
17240596
] | train | Can radiosurgery be used for the DNET tumors? | yesno | Yes, radiosurgery is used for the DNET (Dysembryoplastic neuroepithelial) tumors. However, the level of evidence is limited. | yes | [
"BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNT/DNET) are rare \nepileptogenic tumors. Microsurgery remains the best treatment option, although \ncase reports exist on the use of gamma knife radiosurgery (GKRS) in selected \ncases. We investigated the long-term outcome of GKRS-treated DNTs at our \ninstit... | nan |
5e3247f1fbd6abf43b00005b | [
16434828,
21523724,
23172499,
12558870,
23397792,
21046312,
29330865,
27906102,
27866298,
27729091,
26927177,
16855507,
12199765,
22908888,
26605276,
8865500,
26009571,
20952292,
11449317,
1771248,
31637750
] | train | Can radiotherapy cause radiation induced osteosarcoma? | yesno | Yes, Radiation-induced osteosarcomas are a recognized complication of radiation therapy. | yes | [
"A 35-year-old man developed osteosarcoma of the left parietal and occipital \nbones 16 years after radiotherapy for glioma in the right occipital lobe. \nRadiotherapy of the primary neoplasm used 50 Gy administered to a localized \nfield through two lateral ports. The secondary neoplasm arose contralateral to \nth... | nan |
5a72284b2dc08e987e000001 | [
26566562,
28336098,
23026468,
28638948,
21505639,
10207976,
28511570,
27454517,
21786553,
29169594,
25920637
] | train | Can radius fracture cause carpal tunnel syndrome? | yesno | Yes, carpal tunnel syndrome is a common complication associated with distal radius fractures. | yes | [
"Although the rupture of extensor tendons after distal radius fractures is well \ndescribed, acute flexor tendon ruptures are much less common. We report a case \nof acute rupture of the flexor pollicis longus and flexor carpi radialis tendons \nwith acute carpal tunnel syndrome after a Gustilo-Anderson type II ope... | ['https://meshb.nlm.nih.gov/record/ui?ui=D002349', 'http://www.disease-ontology.org/api/metadata/DOID:12169'] |
603291f21cb411341a000146 | [
32062145,
32012760,
32101001,
32098409,
31833496
] | train | Can saponins be used as adjuvant? | yesno | Yes,
saponin is an ideal adjuvant candidate. | yes | [
"Author information:\n(1)Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina \nTropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo \nHorizonte, Minas Gerais, Brazil.\n(2)Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências \nBiológicas/NUPEB, Departamento de Ciê... | nan |
5e323d79fbd6abf43b000058 | [
29713762,
31088835,
9810442,
22102955,
18373067,
17786001,
17583602,
32649812,
2028149,
32938807,
23227384,
29526937,
10845210,
14714135,
12853693,
23571774,
15685439
] | train | Can secondary glioblastoma be caused by brain irradiation? | yesno | Yes, brain irradiation can cause secondary glioblastoma. | yes | [
"BACKGROUND: Glioblastoma multiforme (GBM), the most common malignant brain \ntumor, mainly manifests as a primary de novo and less frequently as a secondary \nglial neoplasm. GBM has been demonstrated to overexpress the NK-1 receptor and \nsubstance P can be used as a ligand for targeted therapy. Alpha emitters, e... | nan |
54297ed2289fd6cb07000001 | [
23555954,
23266614,
22436374
] | train | Can siRNA affect response to afatinib treatment? | yesno | When afatinib was combined with an EGFR-specific siRNA there was a strong biological effect on growth inhibition and induction of apoptosis. | yes | [
"Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved \nin the development and progression of various types of cancers. However, its \nrole in non-small cell lung cancer (NSCLC) has not been elucidated. The aim of \nthis study was to investigate the contribution of miR-146a to various as... | ['http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030422', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D034741', 'http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090065'] |
58cd675c02b8c6095300003b | [
27154402,
27029895,
27401551,
26903545,
27483324
] | train | Can telomere length shortening be reversed by telomerase? | yesno | Yes, telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia. | yes | [
"Telomerase-mediated telomere elongation provides cell populations with the \nability to proliferate indefinitely. Telomerase is capable of recognizing and \nextending the shortest telomeres in cells; nevertheless, how this mechanism is \nexecuted remains unclear. Here, we show that, in the fission yeast \nSchizosa... | nan |
530cf4fe960c95ad0c000009 | [
5447715,
737550,
1410257,
3855899,
6829791
] | train | Can tetracycline affect tooth formation? | yesno | Tetracycline is incorporated in the teeth during their formation and leads to their permanent staining. A definite relationship between total dosage and staining and duration of administration and staining was established; the condition occurred with greater frequency (in more than one-third of the children) when the t... | yes | [
"In this investigation an attempt has been made to determine the relationship \nbetween the staining of permanent teeth by tetracycline administered during the \nperiod of tooth formation with the dosage of the drug and the duration of \ntherapy. Of 238 subjects whose hospital records indicated ingestion of stated ... | ['http://www.biosemantics.org/jochem#4272839', 'http://www.disease-ontology.org/api/metadata/DOID:1091', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013752', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013754', 'http://www.nlm.nih.gov/cgi/mes... |
5a75fec383b0d9ea6600000b | [
28109959
] | train | Can the CEP290 gene mutations be targeted by AAV-mediated gene therapy? | yesno | The large size of the CEP290 gene prevents its use in adeno-associated virus (AAV)-mediated gene augmentation therapy. | no | [
"As the most common subtype of Leber congenital amaurosis (LCA), LCA10 is a \nsevere retinal dystrophy caused by mutations in the CEP290 gene. The most \nfrequent mutation found in patients with LCA10 is a deep intronic mutation in \nCEP290 that generates a cryptic splice donor site. The large size of the CEP290 \n... | nan |
587dfde9ae05ffb474000001 | [
27723753
] | train | Can the Micro-C XL method achieve mononucleosome resolution? | yesno | Yes. Micro-C XL is an improved method for analysis of chromosome folding at mononucleosome resolution. | yes | [
"We present Micro-C XL, an improved method for analysis of chromosome folding at \nmononucleosome resolution. Using long crosslinkers and isolation of insoluble \nchromatin, Micro-C XL increases signal-to-noise ratio. Micro-C XL maps of \nbudding and fission yeast genomes capture both short-range chromosome fiber \... | nan |
5717bacacb4ef8864c00000d | [
25116390,
23567751,
22116711,
23954445,
25524600,
25619640,
21307199
] | train | Can the apoptosis regulator BAX trigger the release of cytochrome c? | yesno | Yes, altered Bax conformation trigger its redistribution from the cytosol to mitochondria. Subsequently, cytochrome c is released from mitochondria to cytosol. | yes | [
"Apoptosis is frequently induced to inhibit virus replication during infection of \nEnterovirus 71 (EV71). On the contrary, anti-apoptotic pathway, such as PI3K/Akt \npathway, is simultaneously exploited by EV71 to accomplish the viral life cycle. \nThe relationship by which EV71-induced apoptosis and PI3K/Akt sign... | nan |
54edef0594afd6150400000d | [
19483674,
20224565
] | train | Can the iPS cell technology be used in Fanconi anemia therapy? | yesno | iPS cell technology can be used for the generation of disease-corrected, patient-specific cells with potential value for cell therapy applications in Fanconi anemia. | yes | [
"The generation of induced pluripotent stem (iPS) cells has enabled the \nderivation of patient-specific pluripotent cells and provided valuable \nexperimental platforms to model human disease. Patient-specific iPS cells are \nalso thought to hold great therapeutic potential, although direct evidence for \nthis is ... | ['http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D057026', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D051856', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D005199', 'http://www.nlm.nih.gov/cgi/mesh/2015/MB_cg... |
5a857bfffaa1ab7d2e000030 | [
12200417
] | train | Can the yeast protein Abf1 act as insulator? | yesno | Saccharomyces cerevisiae Rap1p and Abf1p proteins are endowed with a potent insulating capacity | yes | [
"Insulators are sequences that uncouple adjacent chromosome domains. Here we have \nshown that Saccharomyces cerevisiae Rap1p and Abf1p proteins are endowed with a \npotent insulating capacity. Insulating domains in Rap1p coincide with previously \ndescribed transcription activation domains, whereas four adjacent s... | nan |
5c9f7bb6ecadf2e73f00003e | [
28961712
] | train | Can therapeutic levels of Vedolizumab be found in the breast milk of nursing mothers following treatment for Inflammatory bowel disease? | yesno | vedolizumab can be detected in the breast milk of nursing mothers. although more data are imperative, the concentrations of vedolizumab in breast milk are minute and are therefore unlikely to result in systemic or gastro-intestinal immune-suppression of the infant. | no | [
"INTRODUCTION: There are no data on the transfer of vedolizumab in breast milk of \nnursing mothers. We aimed to assess the presence of vedolizumab in breast milk \nof nursing inflammatory bowel disease [IBD] patients.\nMETHODS: This was a prospective observational study of vedolizumab-treated \nbreastfeeding patie... | nan |
6025e2641cb411341a0000bb | [
24672280,
31838406
] | train | Can thiotepa be recommended for treatment of osteosarcoma? | yesno | No. Thiotepa did not improve survival of patients with osteosarcoma and therefore can not be recommended for treatment of osteosarcoma. | no | [
"Introduction. Osteosarcoma relapse has a poor prognosis, with less than 25% \nsurvival at 5 years. We describe the experience of the French Society of \nPaediatric Oncology (SFCE) with high dose (HD) thiotepa and autologous stem cell \ntransplantation (ASCT) in 45 children with relapsed osteosarcoma. Patients and ... | nan |
52f89ee42059c6d71c00004d | [
24105977,
23889921
] | train | Can valproic acid act as an activator of AMPK? | yesno | Yes, valproic acid canact as an activator of AMPK. | yes | [
"Valproic acid (VPA) is a widely prescribed anticonvulsant for the treatment of \nepilepsy. Here we demonstrate that VPA is a novel activator of AMP-activated \nprotein kinase (AMPK), a key regulator of cellular metabolism, using primary \nmouse and human hepatocytes. Incubation of primary mouse hepatocytes with VP... | ['http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031588', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D055372', 'http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004679', 'http://www.uniprot.org/uniprot/AAKB1_HUMAN', 'http://amigo.geneontology.or... |
5884755ce56acf5176000007 | [
26420896,
21880994,
25648357,
18751431,
22168970,
27889835,
26976976,
26786929,
24328881,
23523186,
26194676,
25066904,
26925628
] | train | Can valproic acid prolong survival of glioblastoma patients? | yesno | Yes, there is evidence to suggest that valproic acid (VPA) is associated with prolonged survival of glioblastoma patients. Several studies have indicated that VPA has radiosensitizing effects for gliomas and radioprotective influence on normal brain tissue or hippocampal neurons. | yes | [
"BACKGROUND: Epileptogenic glioblastomas are thought to convey a favorable \nprognosis, either due to early diagnosis or potential antitumor effects of \nantiepileptic drugs. We investigated the relationship between survival and \nepilepsy at presentation, early diagnosis, and antiepileptic drug therapy in \ngliobl... | ['https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016019', 'http://www.disease-ontology.org/api/metadata/DOID:3073', 'http://www.disease-ontology.org/api/metadata/DOID:3068', 'http://www.biosemantics.org/jochem#4271063', 'https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Fi... |
56cf32e23975bb303a000006 | [
23090625,
10490914,
11524036,
9400006,
11454918,
12784104,
9252010,
18923402,
10884561,
18538356,
16140280,
15989562,
18418363
] | train | Can venlafaxine block NET and SERT? | yesno | Yes, venlafaxine inhibits both the NET and SERT. | yes | [
"INTRODUCTION: Serotonin and norepinephrine reuptake inhibitors (SNRIs) are \nantidepressants which have high affinity to both serotonin transporter (SERT) \nand norepinephrine transporter (NET). In studies in vitro, SNRIs have been \nreported to show a large variability in the affinity ratio between SERT and NET. ... | ['http://www.biosemantics.org/jochem#http://www.biosemantics.org/jochem#:4277061'] |
572211540fd6f91b68000016 | [
22703872,
11304071,
20943242,
24701066,
24620429,
23042832,
24117525,
23935638,
23715222,
25515801,
9279523,
21217196,
25276464,
23278769,
24973622,
7695937,
16254404,
24379094,
14644703,
2361826,
25050351,
23090806
] | train | Can vitamin B1 deficiency cause encephalopathy? | yesno | Wernicke's encephalopathy (WE) is a severe neurological syndrome caused by thiamine (vitamin B1) deficiency and clinically characterized by the sudden onset of mental status changes, ocular abnormalities, and ataxia. It is commonly associated with heavy alcohol consumption. Other clinical associations are with hypereme... | yes | [
"INTRODUCTION: Wernicke's encephalopathy caused by thiamine deficiency is \ntypically characterised by a mental-status change, oculomotor dysfunction and an \nataxia. Pellagra is the clinical presentation of niacin deficiency comprising \ncutaneous, gastrointestinal and neuropsychiatric manifestations.\nOBSERVATION... | nan |
55435aeced966d112c000007 | [
15046306,
10430918,
15716010,
9294192,
9520433,
12171605,
9190805,
18799480,
10066522,
7482779
] | train | Can we detect DNA strand asymmetries using dinucleotide relative abundance "genomic signatures"? | yesno | The set of dinucleotide relative abundances can be regarded as a genomic signature because, despite diversity between species, it varies little between 50 kilobase or longer windows on a given genome. Thus, dinucleotide relative abundance profiles are species-type specific. These profiles are computed from the base ste... | no | [
"In this study we investigated the correlation between dinucleotide relative \nabundance values (the genomic signature) obtained from bacterial whole-genome \nsequences and two parameters widely used for bacterial classification, 16S rDNA \nsequence similarity and DNA-DNA hybridisation values. Twenty-eight complete... | nan |
530b4f49970c65fa6b00000a | [
22579745,
22674539,
24175175
] | train | Can we use platelet biomarkers to study Alzheimer's disease? | yesno | Yes, platelet biomarkers can be used to study Alzheimer's disease. | yes | [
"Platelets play a fundamental role in hemostasis. Because they do not have a \nnucleus, proteomics is an ideal way to approach their biochemistry. Platelet \nproteomics is still a young field that emerged a decade ago. Initial platelet \nproteomic research focused on general proteome mapping followed by the \nexplo... | ['http://www.disease-ontology.org/api/metadata/DOID:10652', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015415', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000544'] |
534289851eccfd0633000001 | [
10963843,
8656260,
15330181,
17602063,
16267025,
11336600,
19956889,
17661222,
12469164,
20021044,
16015542,
8783671,
10731970,
18204866,
15064010,
12538828,
10553165,
23626702,
9099346,
8952658,
11368288,
15345895,
9703784,
10348266,
9389935,
16116597,
10808697
] | train | Can we use prodrug amifostine to protect healthy cell during chemotherapy? | summary | Effective radiotherapy for patients with cancer should include maximal tumor cell killing with minimal injury to normal tissue. However, current radiation doses that can be delivered without causing severe damage to surrounding normal tissues are often insufficient to eradicate a tumor. Recently, a number of agents hav... | Effective radiotherapy for patients with cancer should include maximal tumor cell killing with minimal injury to normal tissue. However, current radiation doses that can be delivered without causing severe damage to surrounding normal tissues are often insufficient to eradicate a tumor. Recently, a number of agents hav... | [
"Experimental studies have shown that vinorelbine is a powerful radiosensitizer \nin vitro. To date, no reports on clinical activity of the single agent \nvinorelbine as radiosensitizer have been published. The aim of the present phase \nI study was to determine the maximum tolerated dose (MTD) of vinorelbine \nadm... | ['http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004358', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004999', 'http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020011', 'http://www.biosemantics.org/jochem#4217067... |
62068e67c9dfcb9c09000038 | [
34732400
] | train | Can whole genome sequencing be used for diagnosis of mitochondrial disease? | yesno | Yes. Whole genome sequencing is a useful diagnostic test in patients with suspected mitochondrial disorders, yielding a diagnosis in a further 31% after exclusion of common causes. Most diagnoses were non-mitochondrial disorders and included developmental disorders with intellectual disability, epileptic encephalopathi... | yes | [
"Author information:\n(1)Department of Clinical Neurosciences, School of Clinical Medicine, University \nof Cambridge, Cambridge, UK.\n(2)Medical Research Council Mitochondrial Biology Unit, University of Cambridge, \nCambridge, UK.\n(3)East Anglian Medical Genetics Service, Cambridge University Hospitals NHS \nFou... | nan |
5c6d9a157c78d69471000041 | [
29042212,
30298407,
26517836,
25637562,
30324701,
29360926
] | train | Can you computationally predict Molecular Recognition Features (MoRFs) regions in Intrinsically Disordered Proteins (IDPs)? | yesno | Yes. There are various tools available in the literature that enable computational identification of Molecular Recognition Features (MoRFs) regions in intrinsically disordered protein sequences. | yes | [
"MOTIVATION: Intrinsically Disordered Proteins (IDPs) lack stable tertiary \nstructure and they actively participate in performing various biological \nfunctions. These IDPs expose short binding regions called Molecular Recognition \nFeatures (MoRFs) that permit interaction with structured protein regions. Upon \ni... | nan |
58a342e760087bc10a00001c | [
12561154,
21481093,
2534534,
417541,
2240392,
21701137,
10979347,
17091219,
25600788,
8608668,
22197283,
2173098,
26767158,
133304,
18176826,
20650043,
24719163,
21610562,
26386902,
355046,
8642152,
18242414,
8133999,
19063792,
3961454,
17497458,
17470323,
25660... | train | Can you define iatrogenic disease? | factoid | An iatrogenic disease is one that arises from treatment of another illness, such as an arrythmia that results from surgery or and hospital aquired infection in an immunocompromised patient. | illness caused by treatment | [
"PURPOSE: A rare complication of laparoscopic cholecystectomy is defined: \niatrogenic injuries to hepatic artery system which may evolve to pseudoaneurysms \nin the late postoperative period. This rare phenomenon may be overlooked and \npose a challenge to surgeons.\nMATERIAL AND METHODS: We will describe three ca... | ['https://www.nlm.nih.gov/cgi/mesh/2017/MB_cgi?field=uid&exact=Find+Exact+Term&term=D007049'] |
603bc1a81cb411341a000159 | [
20067169,
21087811,
28654435,
22428294,
33223079,
16155434,
16037773,
31998320,
27690672,
11886578,
19209651,
28941526,
31937334,
24141560,
32859770
] | train | Can you summarize Myasthenia Gravis? | summary | Myasthenia gravis (MG) is a neuromuscular disease which affects the central nervous system, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas. Two thirds of MG cases result from sporadic genetic mutations, not inheritance, but their offspring may inherit it from them. | Myasthenia gravis (MG) is a neuromuscular disease which affects the central nervous system, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas. Two thirds of MG cases result from sporadic genetic mutations, not inheritance, but their offspring may inherit it from them. | [
"Myasthenia gravis is an autoimmune neuromuscular disorder characterized by \nskeletal muscle involvement, causing muscle weakness and fatigue. The prevalence \nof the disease is approximately 1:7500 with a maximal prevalence during the \nsecond and third decade in women and the fifth and sixth decade in men, altho... | nan |
56f15c5a2ac5ed1459000012 | [
16082368,
20594338,
20846404,
23161061,
18511461,
22318089,
24223114,
20389291,
21631241,
21411759,
15806097,
23451191,
24557916,
24808958
] | train | Can zinc finger nucleases be used to combat disease? | yesno | Yes, zinc finger nucleases are a useful tool for treating disease. | yes | [
"The ability to achieve site-specific manipulation of the mammalian genome has \nwidespread implications for basic and applied research. Gene targeting is a \nprocess in which a DNA molecule introduced into a cell replaces the \ncorresponding chromosomal segment by homologous recombination, and thus presents \na pr... | ['http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016335', 'http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D015032', 'http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004194', 'http://www.disease-ontology.org/api/metada... |
515870cdd24251bc0500008f | [
19386850,
17594211,
17227206,
20686438,
20960935,
20649801,
23114438,
20237104,
18070960,
22553235,
22383444,
20534805,
20542902,
22796889
] | train | Carbapenemase-producing gram-negative bacteria is a major health concern because their resistance to antibiotics.
List the most frequent carbapenemases found in Enterobacteriaceae. | list | The most frequent carbapenemases in Enterobacteriaceae are OXA-48, KPC, VIM, NDM, IMP, SME, NMC, GES, IMI and MBL. | ['OXA-48', 'KPC', 'VIM', 'NDM', 'IMP', 'SME', 'NMC', 'GES', 'IMI', 'MBL'] | [
"The detection of class A serine-carbapenemases among species of \nEnterobacteriaceae remains a challenging issue. Methods of identification for \nroutine use in clinical microbiology laboratories have not been standardized to \ndate. We developed a novel screening methodology suitable for countries with \nhigh bas... | ['http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004352', 'http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D000903', 'http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0046677', 'http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=F... |
5c58b99586df2b9174000012 | [
20007090,
29863979,
30456447,
30377167
] | train | Cemiplimab is used for treatment of which cancer? | factoid | Cemiplimab is a PD-1 inhibitor that is approved for treatment of metastatic or locally advanced cutaneous squamous cell carcinoma. | cutaneous squamous cell carcinoma | [
"1. ",
"Author information:\n(1)From the Departments of Dermatology and Head and Neck Surgery, University of \nTexas MD Anderson Cancer Center, Houston (M.R.M.), and South Texas Accelerated \nResearch Therapeutics (START), San Antonio (K.P.P.) - both in Texas; the \nDepartment of Medical Oncology, Peter MacCallum... | nan |
5e4601293f54159529000002 | [
29565219,
29514948,
29369733,
29328521,
31424490,
30213803,
28820013,
31796822,
27834394,
31668125,
27300318
] | train | Central Vein Sign is characteristic to which disease? | factoid | Central vein sign on FLAIR* magnetic resonance imaging is highly specific and sensitive for multiple sclerosis. | multiple sclerosis | [
"Purpose The aim of this study was to determine the occurrence and distribution \nof the 'central vein' sign in white matter lesions on susceptibility-weighted \nmagnetic resonance images in patients with multiple sclerosis (MS) and cerebral \nsmall vessel disease (CSVD). Materials and methods T2-weighted and \nflu... | nan |
5c6b810e7c78d6947100002e | [
30205177,
28589525,
28890641,
29688815
] | train | Cerliponase alfa is apprived for treatment of which disease? | factoid | Cerliponase alfa is a recombinant human tripeptidyl peptidase-1 (TPP1) approved for use in patients with neuronal ceroid lipofuscinosis type 2 (CLN2), a paediatric neurodegenerative disease caused by a deficiency in TPP1. | 2 | [
"Treatment with intracerebroventricular (ICV)-delivered cerliponase alfa enzyme \nreplacement therapy (ERT) in a Phase 1/2 study of 24 subjects with CLN2 disease \nresulted in a meaningful preservation of motor and language (ML) function and \nwas well tolerated. Treatment was associated with anti-drug antibody (AD... | nan |
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