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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | A large number of subunits of mammalian K ϩ channels expressed in the CNS have been identified after the cloning of the Shaker gene in Drosophila in 1987 (reviewed in. This work has revealed the existence of an extraordinary diversity of molecular components of voltage-gated K ϩ channels, predicting a functional divers... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | Among the cloned subunits are the members of the Kv and KCNQ (or KQT) families of K ϩ channel proteins, which are pore-forming components of voltage-gated K ϩ channels. The Kv family is divided into several subfamilies based on sequence similarities. Nearly 30 Kv proteins classified in eight subfamilies (Kv1-Kv6 and Kv... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | The goal of this study was to identify the currents mediated by channels containing proteins of the Kv3 subfamily in neurons. There are four known Kv3 genes (Kv3.1-Kv3.4). In heterologous expression systems, Kv3.1 and Kv3.2 proteins express tetraethylammonium (TEA)-sensitive delayed rectifier type currents, whereas Kv3... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | We have shown previously in a study combining immunohistochemical and electrophysiological analysis in slice preparations that drugs that block Kv3.1 currents in heterologous | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked ''advertisement'' in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. | [] | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | expression systems blocked a fraction of the K ϩ current from hippocampal interneurons expressing Kv3.1b proteins that resembles Kv3.1 currents in activation and deactivation properties. However, limitations associated with voltage clamping intact neurons in slices prevented a detailed comparison of the properties of t... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | We have used whole cell patch-clamp methods to analyze the voltage-dependent K ϩ currents of freshly dissociated rat GP neurons to determine whether they contain currents with properties similar to those carried by Kv3.1-Kv3.2 channels. Because of its central roles in movement control and perhaps also cognitive functio... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | Previous electrophysiological analysis of the K ϩ currents of pallidal neurons, in the same species, revealed a low voltageactivating fast inactivating current (I A ), a component with slower inactivation and slow recovery from inactivation that is blocked by micromolar concentrations of 4-AP (I As ), and two maintaine... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | In this study, we first analyzed the expression of Kv3.1 and Kv3.2 proteins in the rat GP with specific antibodies. We also determined the developmental expression of these proteins, allowing us to select tissue at developmental stages in which the proteins are robustly expressed in pallidal neurons. We used pharmacolo... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | Site-specific antibodies against Kv3.1b proteins were prepared by injecting into rabbits the peptide CKESPVIAKYMPTEAVRVT coupled via the cysteine to keyhole limpet hemocyanin (KLH). The peptide corresponds to the carboxyl terminal sequence of the Kv3.1b protein (residues 567-585). The characterization of this antibody ... | [
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{
"section": "INTRO",
"title": "Kv3.1-Kv3.2 Channels Underlie a High-Voltage-Activating Component of the Delayed Rectifier K ϩ Current in Projecting Neurons From the Globus Pallidus"
} | Male Sprague-Dawley rats (2-3 wk old) or male C57Bl6 mice (6 -8 wk old), as well as Kv3.1 Ϫ/Ϫ or Kv3.2 Ϫ/Ϫ ) mice, were anesthetized with an injection of pentobarbital sodium (120 mg/kg ip) and perfused transcardially with 10 -20 ml Heparin (1 U/ml) in phosphate-buffered saline (PBS: 0.06 M sodium phosphate buffer, 0.8... | [
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