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39457696
The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults.
/objectives: An East Asian-specific 1382A>C polymorphism in the mitochondrial open reading frame of the 12S rRNA type-c results in an amino acid substitution from Lys (K) to Gln (Q) at the 14th amino acid residue. This study investigated the association between m.1382A>C polymorphism and sarcopenia, blood lipids, and m...
10.3390/biomedicines12102384
24610723
Strigolactone promotes degradation of DWARF14, an α/β hydrolase essential for strigolactone signaling in Arabidopsis.
Strigolactones (SLs) are phytohormones that play a central role in regulating shoot branching. SL perception and signaling involves the F-box protein MAX2 and the hydrolase DWARF14 (D14), proposed to act as an SL receptor. We used strong loss-of-function alleles of the Arabidopsis thaliana D14 gene to characterize D14 ...
10.1105/tpc.114.122903
36382258
Multiple sclerosis and computational biology (Review).
Multiple sclerosis (MS) is an autoimmune neurodegenerative disease whose prevalence has increased worldwide. The resultant symptoms may be debilitating and can substantially reduce the of patients. Computational biology, which involves the use of computational tools to answer biomedical questions, may provide the basis...
10.3892/br.2022.1579
14768856
Delayed rejection after initial engraftment in non-myeloablative bone marrow transplantation.
Non-myeloablative bone marrow transplantation (NM-BMT) is a newly developed therapeutic strategy for malignant and non-malignant hematological diseases, as well as immunotherapy-responsive solid tumors. The graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect is the major therapeutic effect of this procedure,...
38288263
Clinical Applications, Methodology, and Scientific Reporting of Electrocardiogram Deep-Learning Models: A Systematic Review.
The electrocardiogram (ECG) is one of the most common diagnostic tools available to assess cardio-vascular health. The advent of advanced computational techniques such as deep learning has dramatically expanded the breadth of clinical problems that can be addressed using ECG data, leading to increasing popularity of EC...
10.1016/j.jacadv.2023.100686
34278548
Microglia in the Pathophysiology of Hemorrhagic Stroke and the Relationship Between Microglia and Pain After Stroke: A Narrative Review.
Stroke is a leading cause of death worldwide, and about a quarter of stroke patients are dead within 1 month. The prognosis is even worse for those with hemorrhagic stroke because the 1-month mortality approaches 50%. Besides, most patients who survive experience complications such as nausea, vomiting, and chronic pain...
10.1007/s40122-021-00288-3
31344850
Evaluation of Diagnostic Performance of Three Indirect Enzyme-Linked Immunosorbent Assays for the Detection of IgG Antibodies to Ebola Virus in Human Sera.
Filovirus serological diagnosis and epidemiological investigations are hampered due to the unavailability of validated immunoassays. Diagnostic performance of three indirect enzyme-linked immunosorbent assays (I-ELISA) was evaluated for the detection of IgG antibody to Ebola virus (EBOV) in human sera. One I-ELISA was ...
10.3390/v11080678
38482641
Our Data, Our Question: Public-Centric Approaches to Administrative Data Analysis.
There is growing recognition of the importance of patient, public and community engagement in health research, which has not been used widely in analyzing health administrative datasets. In Ontario, health data are stewarded by ICES, whose strategic decision making is guided by a diverse Public Advisory Council (PAC). ...
10.12927/hcq.2024.27261
26719384
Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.
Aggregation and neuron-to-neuron transmission are attributes of α-synuclein relevant to its pathogenetic role in human synucleinopathies such as Parkinson's disease. Intraparenchymal injections of fibrillar α-synuclein trigger widespread propagation of amyloidogenic protein species via mechanisms that require expressio...
10.1093/brain/awv376
29230579
Prevalence of cysticercosis in Estonian pigs and cattle.
Taenia solium has been ranked as the most important foodborne parasite and Taenia saginata as the most commonly found human Taenia tapeworm worldwide. The last official reports of taeniosis from Estonia were in 2003 for T. solium and 2012 for T. saginata. By law, all animal cases of cysticercosis must be registered and...
10.1007/s00436-017-5710-9
35100348
Database of glutamate-gated chloride (GluCl) subunits across 125 nematode species: patterns of gene accretion and sequence diversification.
Glutamate-gated chloride channels belong to the Cys-loop receptor superfamily. Glutamate-gated chloride channels are activated by glutamate and form substrates for the antiparasitic drugs from the avermectin family. Glutamate-gated chloride channels are pentameric, and each subunit contains an N-terminal extracellular ...
10.1093/g3journal/jkab438
35845893
Survival Risk Prediction of Esophageal Squamous Cell Carcinoma Based on BES-LSSVM.
Esophageal squamous cell carcinoma (ESCC) is one of the highest incidence and mortality cancers in the world. An effective survival prediction model can improve the quality of patients' survival. In this study, ten indicators related to the survival of patients with ESCC are founded using genetic algorithm feature sele...
10.1155/2022/3895590
30266699
Technical Trick of Combined Embolization of Inaccessible Dural Arteriovenous Fistula by Endovascular Route Only.
Endovascular embolization of dural arteriovenous fistula may not be a feasible approach depending on the location and/or surrounding structures. Combined embolization comprising endovascular embolization by direct puncture of the sinus after small craniotomy under fluoroscopic guidance is a good treatment option for le...
10.1016/j.wneu.2018.09.122
28421094
Cucumber CsBPCs Regulate the Expression of CsABI3 during Seed Germination.
Cucumber seeds with shallow dormancy start to germinate in fruit that are harvested late. ABSCISIC ACID INSENSITIVE3 (ABI3), a transcription factor in the abscisic acid (ABA) signaling pathway, is one of the most important regulators in the transition from late embryogenesis to germination. Our analysis found a candida...
10.3389/fpls.2017.00459
9850455
Management of recipients of hepatic allografts harvested from donors with malignancy diagnosed shortly after transplantation.
Transmission of undiagnosed malignancy with the graft is a dramatic complication of liver transplantation. Alternatives in the management of the recipients of livers, harvested from donors with malignancy diagnosed shortly after transplantation, are either early re-transplantation or close follow-up without re-operatio...
15549843
New tin templates for the synthesis of macrocyclic polythiaether-polythiaester ligands.
The preparation of new tin templates, stannathianes 1-3 is described. New templates have been successfully applied to the synthesis of macrocyclic polythialactones 4-9 by cyclization of corresponding stannathianes 1-3 with pimeloyl dichloride.
10.1021/jo048712l
37300046
Machine-Learning-Based Indoor Localization under Shadowing Condition for P-NOMA VLC Systems.
The localization of agents for collaborative tasks is crucial to maintain the quality of the communication link for successful data transmission between the base station and agents. Power-domain Non-Orthogonal Multiple Access (P-NOMA) is an emerging multiplexing technique that enables the base station to accumulate sig...
10.3390/s23115319
1513148
Venoarterial extracorporeal membrane oxygenation--how safe is it? Evaluation with a new experimental model.
This study was undertaken to find out if about 25% right cardiac output is sufficient for preservation of lung function during prolonged periods of venoarterial extracorporeal membrane oxygenation. Six healthy pigs weighing 57 kg were subjected to 18-hour venoarterial extracorporeal membrane oxygenation. During this pe...
20666016
[French biomedical competitiveness clusters: opportunities for public-private partnerships].
A "competitive cluster" is a partnership between businesses, research units and training centers, working together to generate synergies for innovative projects in a particular geographic area. Since 2005, the first five calls for cluster projects have led to the funding of 645 R&D projects involving 13,000 researchers...
22733744
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
To protect the organism against autoimmunity, self-reactive effector/memory T cells (T(E/M)) are controlled by cell-intrinsic and -extrinsic regulatory mechanisms. However, how some T(E/M) cells escape regulation and cause autoimmune disease is currently not understood. Here we show that blocking IL-7 receptor-α (IL-7R...
10.1073/pnas.1203692109
21473166
Seeing Jay-Z in Taipei.
How does the newly arrived immigrant respond to the news that an identity already awaits him? How does an African American hip-hop artist translate his struggles and triumphs across oceanic divides? What significance do American demographic shifts have in a global context? Hsu's essay examines what happens once individ...
10.1162/daed_a_00068
22539946
Synthetic biology: mapping the scientific landscape.
This article uses data from Thomson Reuters Web of Science to map and analyse the scientific landscape for synthetic biology. The article draws on recent advances in data visualisation and analytics with the aim of informing upcoming international policy debates on the governance of synthetic biology by the Subsidiary ...
10.1371/journal.pone.0034368
36011618
Protection of Prisoners with Mental Health Disorders in Italy: Lights and Shadows after the Abolition of Judicial Psychiatric Hospitals.
In Italy, a person suffering from a mental disorder who commits a crime will be given a custodial security order and serve the period of admission at a Residenza per la esecuzione delle misure di sicurezza (REMS) (Residence for the Execution of Security Measures, hereinafter "REMS"). These institutions have been establ...
10.3390/ijerph19169984
6853622
[Secondary hyperparathyroidism. Modern concepts of its diagnosis and treatment. Apropos of 45 cases].
An analysis of different problems raised by secondary hyperparathyroidism. This condition most often follows chronic renal failure responsible for hyperphosphataemia followed by hypocalcaemia which causes parathyroid stimulation with hyperplasia. Clinical features are dominated by osteopathic manifestations and pruritu...
38684683
Spatial decoupling of bromide-mediated process boosts propylene oxide electrosynthesis.
The electrochemical synthesis of propylene oxide is far from practical application due to the limited performance (including activity, stability, and selectivity). In this work, we spatially decouple the bromide-mediated process to avoid direct contact between the anode and propylene, where bromine is generated at the ...
10.1038/s41467-024-48070-1
7287814
Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ.
After fixation with glutaraldehyde and impregnation with tannic acid, the membrane that underlies the nerve terminals in Torpedo marmorata electroplaque presents a typical asymmetric triple-layered structure with an unusual thickness; in addition, it is coated with electron-dense material on its inner, cytoplasmic face...
10.1083/jcb.90.2.418
38393038
Lipidome Plasticity Enables Unusual Photosynthetic Flexibility in Arctic vs. Temperate Diatoms.
The diatom lipidome actively regulates photosynthesis and displays a high degree of plasticity in response to a light environment, either directly as structural modifications of thylakoid membranes and protein-pigment complexes, or indirectly via photoprotection mechanisms that dissipate excess light energy. This accli...
10.3390/md22020067
17614210
Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures.
Recurring patterns of neural activity, a potential substrate of both information transfer and transformation in cortical networks, have been observed in the intact brain and in brain slices. Do these patterns require the inherent cortical microcircuitry of such preparations or are they a general property of self-organi...
10.1016/j.neuroscience.2007.05.025
20165936
Comparative study of the ramification patterns of the subclavian branches as the subclavian artery passes in front or behind the scalenus anterior muscle.
We investigated the ramification patterns of four subclavian branches (i. e., vertebral artery, internal thoracic artery, thyrocervical trunk, and costocervical trunk) as the subclavian artery passes in front or behind the scalenus anterior muscle. The investigation was carried out on 56 cadavers (112 cases) during stu...
10.1007/s12565-010-0072-8
20933393
Optimization of processing conditions for the fractionation of triticale straw using pressurized low polarity water.
Pressurized low polarity water (PLPW) fractionation of triticale straw was optimized to maximize hemicellulose and lignin yield, and to produce a cellulose rich fraction for biofuels production. The optimum PLPW conditions for hemicellulose yield was determined to be 165 °C, with a flow rate of 115 mL/min, and a solven...
10.1016/j.biortech.2010.09.064
37266786
Potential toxic effects of titanium oxide (TiO 2 ) nanoparticles on the biological, biochemical, and histological aspects of the land snail Helix aspersa.
Nanotechnology has come a long way in our lives. However, it maintains some negative effects on the environment. This study aims to use the land snail Helix aspersa as a bioindicator. Titanium dioxide nanoparticles (TiO 2 NPs) had been used at 70 and 140 µg/L for two weeks by the spraying method. The oxidative biomarke...
10.1007/s11356-023-27666-y
23074286
miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer.
The miRNAs have great potential as biomarkers and therapeutic agents owing to their ability to control multiple genes and potential to influence cellular behavior. Here, we identified that miR-23b is a methylation-silenced tumor suppressor in prostate cancer. We showed that miR-23b expression is controlled by promoter ...
10.1158/0008-5472.CAN-12-2181
36214842
Study on the Interaction between Four Typical Carotenoids and Human Gut Microflora Using an in Vitro Fermentation Model.
Recent studies indicated a strong relationship between carotenoids and gut microflora. However, their structure-activity relationship remains unclear. This study evaluated the interaction between four typical carotenoids (β-carotene, lutein, lycopene, and astaxanthin) and gut microflora using an in vitro fermentation m...
10.1021/acs.jafc.2c03464
19595160
[Long-term outcome of operatively and non-operatively managed high-grade intracranial arteriovenous malformations and factors influencing postoperative neurological deficits].
To compare the effects of surgical and non-surgical treatments for high-grade intracranial arteriovenous malformation (AVM), identify the determinants of neurological function deterioration after surgery, and calculate the annual hemorrhage rate. 98 high-grade intracranial AVM patients underwent surgery, and 44 high-gr...
24295705
Isolation and characterization of acid-soluble collagen from the scales of marine fishes from Japan and Vietnam.
Acid-soluble collagen (ASC) was successfully extracted from the scales of lizard fish (Saurida spp.) and horse mackerel (Trachurus japonicus) from Japan and Vietnam and grey mullet (Mugil cephalis), flying fish (Cypselurus melanurus) and yellowback seabream (Dentex tumifrons) from Japan. ASC yields were about 0.43-1.5%...
10.1016/j.foodchem.2013.10.094
34202302
Coil Combination of Multichannel Single Voxel Magnetic Resonance Spectroscopy with Repeatedly Sampled In Vivo Data.
Magnetic resonance spectroscopy (MRS), as a noninvasive method for molecular structure determination and metabolite detection, has grown into a significant tool in clinical applications. However, the relatively low signal-to-noise ratio (SNR) limits its further development. Although the multichannel coil and repeated s...
10.3390/molecules26133896
38715553
Empagliflozin and Dapagliflozin Therapies Favorably Alter QRS-T Angle and Cardiac Repolarization Parameters in Patients with Heart Failure.
Recent randomized clinical trials demonstrated that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2is) reduces the risk of cardiac mortality due to sudden cardiac death and progressive pump failure in patients with heart failure (HF). Mechanisms underlying the potential anti-arrhythmic effects of SGLT2i...
10.19102/icrm.2024.15044
25902165
Effect of NF- κ B inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer.
To investigate the effects of NF- κ B inhibitor pyrrolidine dithiocarbamate hydrochloride (PDTC) on vascular endothelial growth factor (VEGF) and endostatin expression in mice with Lewis lung cance; and its mechanism. Mice survival rate and anti-tumor effects were observed in different concentrations of NF- κ B inhibit...
10.1016/S1995-7645(14)60319-9
25296254
R-loops induce repressive chromatin marks over mammalian gene terminators.
The formation of R-loops is a natural consequence of the transcription process, caused by invasion of the DNA duplex by nascent transcripts. These structures have been considered rare transcriptional by-products with potentially harmful effects on genome integrity owing to the fragility of the displaced DNA coding stra...
10.1038/nature13787
2130743
Use of lower limb prosthesis among elderly amputees.
Forty-seven elderly patients (21 males and 26 females) with lower limb amputation, and with prostheses fitted were studied. Their ages ranged from 65 years to 91 years old, with an average of 75.4 years. The three most common contributory causes for amputation were diabetes mellitus, vascular occlusion and carcinoma of...
25232400
Expression of Indian hedgehog is negatively correlated with APC gene mutation in colorectal tumors.
The regulatory mechanism of Indian hedgehog (IHH) in colorectal carcinogenesis has not been elucidated. In the current study, the expression of IHH were investigated in 7 digestive tract cancer cell lines, and in 10 normal colorectal mucosas (NCs), 30 hyperplastic polyps (HPs), 35 colorectal adenomas (ADs), and 40 colo...
32129329
A facile strategy based on the metal-free design of carbon to deliver an insight into the active sites for liquid phase carbocatalysis.
An effective method to study the active sites for carbocatalysis is proposed based on designing a carbon catalyst in the absence of metal as the growth catalyst. The results suggest that the oxygenated groups on the aromatic carbons are mainly responsible for the catalytic reduction of nitrobenzene and some other react...
10.1039/c9cc09918b
20527828
Hydrogen bond-induced pair formation of glycine on the chiral Cu{531} surface.
Enantio-specific interactions on intrinsically chiral or chirally modified surfaces can be identified experimentally via comparison of the adsorption geometries of similar nonchiral and chiral molecules. Information about the effects of substrate-related and intermolecular interactions on the adsorption geometry of gly...
10.1021/la1012796
33135223
Ischemic stroke, obesity, and the anti-inflammatory role of melatonin.
Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of...
10.1002/biof.1690
32125046
Up-regulation of SNHG16 induced by CTCF accelerates cardiac hypertrophy by targeting miR-182-5p/IGF1 axis.
Long non-coding RNA (lncRNA) SNHG16 has been reported to be significant regulators in multiple cancers. However, never has the relationship between it and cardiac hypertrophy been studied until now. In this study, angiotensin II (Ang II)-treated cardiomyocytes isolated from neonatal mice were used as a model of cardiac...
10.1002/cbin.11333
26379369
Does Head Start differentially benefit children with risks targeted by the program's service model?
Data from the Head Start Impact Study ( N = 3540) were used to test for differential benefits of Head Start after one program year and after kindergarten on pre-academic and behavior outcomes for children at risk in the domains targeted by the program's comprehensive services. Although random assignment to Head Start p...
10.1016/j.ecresq.2015.08.001
4855391
Viral proteins formed in a cell-free rabbit reticulocyte system programmed with RNA from a temperature-sensitive mutant of Sindbis virus.
Viral messenger RNA was isolated from BHK cells infected with a temperature-sensitive mutant of Sindbis virus and was further purified using an oligo(dT) column. Addition of this mRNA cell-free extracts from rabbit reticulocytes led to formation of discrete authentic viral capsid protein when the reaction was performed...
10.1128/JVI.14.3.664-671.1974
25976944
Cardiac arrhythmias in stroke unit patients. Evaluation of the cardiac monitoring data.
Cardiac arrhythmias are frequent in acute stroke. Stroke units are widely equipped with cardiac monitoring systems. Pre-existing heart diseases and heart-brain interactions may be implicated in causing cardiac arrhythmias in acute stroke. This article analyses cardiac arrhythmias detected in patients hospitalised in a ...
10.1016/j.nrl.2015.03.013
21732168
Epidemiology and outcome following post-surgical admission to critical care.
To describe the factors related to outcome in patients admitted to the intensive care unit (ICU) after major surgery at a national level (in Austria). Analysis of a prospectively collected database of ICU admissions over an 11-year period. Factors associated with mortality and how this changed with time were explored u...
10.1007/s00134-011-2299-9
14764630
Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo.
The regulation of TRH gene expression in the paraventricular nucleus of the hypothalamus (PVH) by leptin is critical for normal function of the thyroid axis in rodents and humans. The TRH neuron in the PVH expresses both leptin and melanocortin-4 receptors, suggesting that both signaling systems may regulate TRH gene e...
10.1210/en.2003-1312
7096454
Dissociated occurrence of single-gene mutation and oncogenic transformation in C3H 10T1/2 cells exposed to ultraviolet light and caffeine.
We examined the relationship of cytotoxicity, mutagenesis, and malignant transformation by measuring in parallel clonogenic survival, mutation to ouabain resistance, and malignant transformation in cultured C3H mouse 10T1/2 cells. Exposure to caffeine alone for 48 hours was cytotoxic and induced transformation in a dos...
10.1002/jcp.1041110313
14531891
Innate immunity and biodefence vaccines.
Host defence in vertebrates is achieved by the integration of two distinct arms of the immune system: the innate and adaptive responses. The innate response acts early after infection (within minutes), detecting and responding to broad cues from invading pathogens. The adaptive response takes time (days to weeks) to be...
10.1046/j.1462-5822.2003.00318.x
25311121
Sequential recovery of macromolecular components of the nucleolus.
The nucleolus is involved in a number of cellular processes of importance to cell physiology and pathology, including cell stress responses and malignancies. Studies of macromolecular composition of the nucleolus depend critically on the efficient extraction and accurate quantification of all macromolecular components ...
10.1007/978-1-4939-1680-1_5
21793440
The relationship between the numbers of Salmonella Enteritidis, Salmonella Heidelberg, or Salmonella Hadar colonizing reproductive tissues of experimentally infected laying hens and deposition inside eggs.
Contamination of eggs by Salmonella Enteritidis has been a prominent cause of human illness for several decades and is the focus of a recently implemented national regulatory plan for egg-producing flocks in the United States. Salmonella Heidelberg has also been identified as an egg-transmitted pathogen. The deposition...
10.1637/9540-092810-Reg.1
8242163
Bond strength of composite to alloy treated with bonding systems.
The in-vitro bond strengths of a composite bonded to a nickel-chromium-beryllium alloy treated by eight bonding systems were measured after three storage conditions. Nickel-chromium-beryllium alloy samples were treated by eight commercial bonding systems including adhesive composite cements, all-purpose bonding agents,...
10.1111/j.1532-849x.1993.tb00391.x
28975281
Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery.
Postsurgical fibrosis is a critical determinant of the long-term success of glaucoma surgery, but no reliable biomarkers are currently available to stratify the risk of scarring. To compare the clinical phenotype of patients with conjunctival fibrosis after glaucoma surgery with candidate gene expression tissue biomark...
10.1001/jamaophthalmol.2017.3407
3191147
A re-evaluation of the molecular size of duck epsilon-crystallin and its comparison with avian lactate dehydrogenases.
A biochemical comparison of epsilon-crystallin isolated from the duck lens and lactate dehydrogenases of chicken heart has been made in order to establish the structural and functional identities of these two proteins. The native molecular weight of epsilon-crystallin was re-examined by combining sedimentation and gel-...
10.1016/0167-4838(88)90288-9
22707939
Information processing and integration with intracellular dynamics near critical point.
Recent experimental observations suggest that cells can show relatively precise and reliable responses to external signals even though substantial noise is inevitably involved in the signals. An intriguing question is the way how cells can manage to do it. One possible way to realize such response for a cell is to evol...
10.3389/fphys.2012.00203
24985538
Disparities in perceived unmet need for supportive services among patients with lung cancer in the Cancer Care Outcomes Research and Surveillance Consortium.
The authors investigated the prevalence, determinants of, and disparities in any perceived unmet need for 8 supportive services (home nurse, support group, psychological services, social worker, physical/occupational rehabilitation, pain management, spiritual counseling, and smoking cessation) by race/ethnicity and nat...
10.1002/cncr.28801
36454615
Preliminary Results of an Interdisciplinary Behavioral Program to Improve Access to Preventative Dental Care for Adults With Intellectual and Developmental Disabilities.
Adults with intellectual and developmental disabilities (AIDD) experience significant oral health disparities, partially due to perceived behavioral issues. This article describes the preliminary outcomes of a developing interdisciplinary (dental, medical, behavioral) program involving a behavioral intervention for AID...
10.1352/1934-9556-60.6.504
31101060
System within systems: challenges and opportunities for the Expanded Programme on Immunisation in Pakistan.
Pakistan has one of the highest infant and child mortality rates in the world, half of these occurring due to vaccine-preventable diseases. The country started its Expanded Programme on immunisation (EPI) in 1978. However, the programme's performance is often questioned, as the Immunisation rates have been chronically ...
10.1186/s12961-019-0452-z
15695479
Analysis of grain boundaries in CoCrTa and CoPtCrB HDD media by analytical transmission electron microscopy.
Crystallographic structures and elemental distributions of grain boundaries in cobalt (Co)-based hard disk drive (HDD) media of CoCrTa and CoPtCrB were analysed by analytical transmission electron microscopy (TEM). CoCrTa medium had crystalline grain boundaries with extremely distorted (0002) planes of hexagonal close-...
10.1093/jmicro/dfh047
2089122
A new prenylated isoflavone and triterpenoids from Erythrina eriotriocha.
In addition to known triterpenoids maniladiol [6] and serrat-14-ene-3 beta,21 alpha-diol [7], two new compounds, one oleanane derivative designated as 28-acetoxyerythrodiol [1] and one isoflavone designated as 5,4'-dimethoxy-3'-prenylbiochanin A [5], have been isolated and characterized from the CHCl3 extract of the st...
10.1021/np50072a024
10022031
Histaminergic ligands attenuate barrel rotation in rats following unilateral labyrinthectomy.
In this paper we present a unilateral labyrinthectomy (UL) surgical procedure in rats that was derived from previous techniques. The utility of this model to assess vestibular dysfunction was evaluated by examining the ability of clinically used histaminergic agents and more selective H3 receptor antagonists to attenua...
31489781
The Itinerant 2D Electron Gas of the Indium Oxide (111) Surface: Implications for Carbon- and Energy-Conversion Applications.
Transparent conducting oxides (TCO) have integral and emerging roles in photovoltaic, thermoelectric energy conversion, and more recently, photocatalytic systems. The functional properties of TCOs, and thus their role in these applications, are often mediated by the bulk electronic band structure but are also strongly ...
10.1002/smll.201903321
23205352
White coats as a vehicle for bacterial dissemination.
White coats are known to be potential transmitting agents of multi-drug resistant organisms. This study was conducted to determine the level and type of microbial contamination present on the white coats of medical students in order to assess the risk of transmission of pathogenic micro-organisms by this route in a hos...
10.7860/JCDR/2012/4286.2364
31121588
Touch Imprint Cytology: A Rapid and Accurate Method for Diagnosis of Oral Cancer.
Touch imprint cytology (TIC) is a rapid and cheap method and can be used as an adjunct to biopsy for the evaluation of suspected malignancy. We evaluated the advantages and limitations of TIC for the preoperative diagnosis of oral squamous cell carcinoma. We used 280 incisional biopsies of clinically suspected oral squ...
10.1159/000500006
26813620
Integrating palliative care with usual care of diabetic foot wounds.
Palliative care is a philosophy and a system for deciding care and can be used alone or integrated with usual chronic disease care. Palliative care encompasses end-of-life care. Palliative care aims to enhance quality of life, optimize function and manage symptoms including early in the course of chronic diseases. The ...
10.1002/dmrr.2758
33135675
Multi-crystal data collection using synchrotron radiation as exemplified with low-symmetry crystals of Dps.
Multi-crystal data collection using synchrotron radiation was successfully applied to determine the three-dimensional structure of a triclinic crystal form of Dps from Escherichia coli at 2.0 Å resolution. The final data set was obtained by combining 261 partial diffraction data sets measured from crystals with an aver...
10.1107/S2053230X20012571
25100301
Status of intestinal parasitic infections among residents of Jimma Town, Ethiopia.
Intestinal parasites cause considerable morbidity and mortality in the world, especially in developing countries like Ethiopia. Both urban and rural inhabitants are vulnerable to infection with intestinal parasites in developing countries. The aim of this study was to determine the status of intestinal parasitic infect...
10.1186/1756-0500-7-502
18564337
Antagonistic interplay of Swi1 and Tup1 on filamentous growth of Candida albicans.
Candida albicans is a polymorphic human opportunistic pathogen in which the Swi-Snf complex functions as an activator whereas Tup1 acts as a general repressor during the yeast-hyphae transition. In Saccharomyces cerevisiae, the interplay between the Swi-Snf complex and the Tup1-Ssn6 repressive complex regulates the bal...
10.1111/j.1574-6968.2008.01236.x
26020210
Individual variation in eating speed of dry sows.
We investigated the variation in eating speed by individual pregnant sows and the influence of feeding dry compared to wet feed. A total of 39 Norwegian Landrace × Yorkshire dry sows, 13 primiparous and 26 multiparous, were included in the experiment. In experimental period 1, each sow was offered 2.2 kg of a standard ...
10.2527/jas.2014-8438
30031243
Resolving host-microbe interactions in the gut: the promise of in vitro models to complement in vivo research.
While animal models remain essential for inferring causality, they exhibit important limitations, which restrict the direct translation of findings into new approaches aimed at steering host-microbe interactions for the improvement of human health. Different in vitro models have therefore been developed which incorpora...
10.1016/j.mib.2018.07.001
27399807
The combination of bleomycin with suicide or interferon-β gene transfer is able to efficiently eliminate human melanoma tumor initiating cells.
We explored the potential of a chemogene therapy combination to eradicate melanoma tumor initiating cells, key producers of recurrence and metastatic spread. Three new human melanoma cell lines, two obtained from lymph nodes and one from spleen metastasis were established and characterized. They were cultured as monola...
10.1016/j.biopha.2016.06.038
17930162
Stochastic electromagnetic radiation of complex sources.
The emission of electromagnetic radiation by localized complex electric charge and current distributions is studied. A statistical formalism in terms of general dynamical multipole fields is developed. The appearing coefficients are treated as stochastic variables. Hereby as much as possible a priori physical knowledge...
10.1103/PhysRevE.76.026602
30083418
Investing Early: Taking Stock of Outcomes and Economic Returns from Early Childhood Programs.
The past two decades have been characterized by a growing body of research from diverse disciplines-child development, psychology, neuroscience, and economics, among others-demonstrating the importance of establishing a strong foundation in the early years of life. The research evidence has served to document the range...
33917648
Room-Temperature Catalyst Enables Selective Acetone Sensing.
Catalytic packed bed filters ahead of gas sensors can drastically improve their selectivity, a key challenge in medical, food and environmental applications. Yet, such filters require high operation temperatures (usually some hundreds °C) impeding their integration into low-power (e. g., battery-driven) devices. Here, ...
10.3390/ma14081839
10729743
The number of nephrons in the mammalian kidney: environmental influences play a determining role.
Several lines of evidence, mostly derived from animal studies, indicate that changes in the fetal environment may affect the renal development. Fetal growth retardation is associated with a nephron deficit in both humans and animals. Changes in the supply of vitamin A to the fetus may be responsible for the variations ...
10.1159/000020649
26353815
A low-cost alternative for nasolaryngoscopy simulation training equipment: a randomised controlled trial.
Flexible nasolaryngoscopy is a key diagnostic procedure used in many specialities. Simulation-based teaching is beneficial for endoscopy training, but it is expensive. This study assessed whether an inexpensive simulation model is an effective training method for flexible nasolaryngoscopy. A three-armed, randomised, co...
10.1017/S0022215115002388
39182573
Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study.
To our knowledge, no large observational study has compared the incidence and risk factors for extubation failure within 48 h and during ICU stay in the same cohort of unselected critically ill patients with and without obesity. What are the incidence and risk factors of extubation failure in patients with and without ...
10.1016/j.chest.2024.07.171
34274811
The Sleep Regularity Questionnaire: development and initial validation.
Sleep is a critically important behavior which influences diverse aspects of health, functioning, and longevity. An increasing literature suggests the importance of sleep regularity, also referred to as sleep inconsistency, sleep variability, or intraindividual variability in sleep. Given there is no brief, subjective ...
10.1016/j.sleep.2021.06.028
25922837
Survival of Mexican Children with Acute Lymphoblastic Leukaemia under Treatment with the Protocol from the Dana-Farber Cancer Institute 00-01.
Our aim in this paper is to describe the results of treatment of acute lymphoblastic leukaemia (ALL) in Mexican children treated from 2006 to 2010 under the protocol from the Dana-Farber Cancer Institute (DFCI) 00-01. The children were younger than 16 years of age and had a diagnosis of ALL de novo. The patients were c...
10.1155/2015/576950
23668697
Anti tumor necrosis factor - alpha adalimumab for complex regional pain syndrome type 1 (CRPS-I): a case series.
Evidence suggests tumor necrosis factor-alpha (TNF-α) mediates, at least in part, symptoms and signs in complex regional pain syndrome (CRPS). Here, we present a case series of patients with CRPS type 1, in whom the response to the anti-TNF-α adalimumab was assessed. Ten patients with CRPS type 1 were recruited. Assess...
10.1111/papr.12070
3492594
Cytologic transformation in cutaneous T cell lymphoma: a clinicopathologic entity associated with poor prognosis.
The clinical course of cutaneous T cell lymphoma (mycosis fungoides and Sezary syndrome) is generally indolent, but in occasional patients becomes fulminant. We found that biopsies from patients with accelerating disease can reveal cytologic transformation from previously observed small, convoluted lymphocytes to large...
10.1200/JCO.1987.5.2.208
17574564
Adsorption of Me-HEDP complexes onto gamma-Al2O3.
This work studies the adsorption of Me-1-hydroxiethane-(1,1-diphosphonic acid) (HEDP) complex onto alumina in the pH range from 5.0 to 9.5. The extent of HEDP adsorption is not significatively affected by the presence of Me(II), while, HEDP has an interesting effect on Me(II) adsorption. At high surface covering, Cu(II...
10.1016/j.jcis.2007.05.050
18276352
Cumulant-based parameter estimation using structured networks.
A two-level three-layer structured network is developed to estimate the moving-average model parameters based on second-order and third-order cumulant matching. The structured network is a multilayer feedforward network composed of linear summers in which the weights of these summers have a clear physical meaning. The ...
10.1109/72.80292
19996442
Association of Helicobacter pylori infection and height of Mexican children of low socioeconomic level attending boarding schools.
This study evaluated the association between Helicobacter pylori infection and height in a population of schoolchildren of a low socioeconomic level regarding growth-related micronutrient status. It was a cross-sectional study of 685 children 5-13 years of age. Height and weight were recorded, a (13)C urea breath test ...
10.4269/ajtmh.2009.09-0107
32962229
Identification of Acupoint Indication from Reverse Inference: Data Mining of Randomized Controlled Clinical Trials.
The specificity of acupoint indication (i. e., reverse inference-diseases for which an acupoint could be used) might differ from the specificity of acupoint selection (i. e., forward inference-acupoints used for a disease). In this study, we explore acupoint specificity through reverse inferences from the dataset of pr...
10.3390/jcm9093027
25697814
Farmedial versus anteromedial portal drilling of the femoral tunnel in ACL reconstruction: a computed tomography analysis.
The success of ACL reconstruction is predicated on a variety of factors. Tunnel placement plays one of the most significant roles in achieving knee kinematics and function. The purposes of this study were to compare femoral tunnel position, angle, length and posterior wall blow-out after ACL reconstruction with hamstri...
10.1007/s00402-015-2176-z
17228855
[Metabolomics and medical practice].
High resolution NMR spectroscopy, currently known as "metabolomics", is a technology enabling the rapid, noninvasive and low cost determination of low molecular weigh metabolites (e. g. aminoacids) in biological fluids such as plasma, urine, saliva, cerebrospinal fluid and others. According to Nicholson "Metabolomics i...
29038836
Automated DXA-based finite element analysis for hip fracture risk stratification: a cross-sectional study.
Fracture risk indices (FRIs) generated from DXA-based finite element analysis were associated with hip fracture independent of FRAX score computed with femoral neck bone mineral density (BMD). Prospective studies are warranted to determine whether FRIs represent an improvement over BMD for predicting incident hip fract...
10.1007/s00198-017-4232-8
36175288
Racial and ethnic disparities in the timing of orchiopexy for cryptorchidism.
Many children do not undergo surgery for cryptorchidism in a timely fashion, increasing risk of infertility and malignancy. Racial and ethnic disparities in surgery timing has been suggested in other specialties, but has not been well-explored in Pediatric Urology. Our aim was to investigate the association of race and...
10.1016/j.jpurol.2022.09.004
28882426
Statistical analysis of solid waste composition data: Arithmetic mean, standard deviation and correlation coefficients.
Data for fractional solid waste composition provide relative magnitudes of individual waste fractions, the percentages of which always sum to 100, thereby connecting them intrinsically. Due to this sum constraint, waste composition data represent closed data, and their interpretation and analysis require statistical me...
10.1016/j.wasman.2017.08.036
32863575
Destructive Creation at Work: How Financial Distress Spurs Entrepreneurship.
Using U. S. Census firm-worker data, I document that firms' financial distress has an economically important effect on employee departures to entrepreneurship. The impact is amplified in the high-tech and service sectors, where employees are key assets. In states with enforceable noncompete contracts, the effect is mit...
10.1093/rfs/hhz110
37668007
Digest: Urbanization shapes selection altering food webs.
How has urbanization altered the relationships between species and selection on phenotypes? To address this question, Palacio and Ordano measured trait and frugivore selection in blue passionflower (Passiflora caerulea) in three different localities. Their analysis revealed changes in avian selection with urbanization,...
10.1093/evolut/qpad161
12453780
Model Predictive Impedance Control: A Model for Joint Movement.
Impedance control has been suggested as the strategy employed by the central nervous system to control human postures and movements. A realization of this strategy is presented that uses a model predictive control algorithm as a higher motor controller. External disturbances are explicitly included in the model. The co...
10.1080/00222899709600836
26333663
Long-lasting modification of soil fungal diversity associated with the introduction of rabbits to a remote sub-Antarctic archipelago.
During the late nineteenth century, Europeans introduced rabbits to many of the sub-Antarctic islands, environments that prior to this had been devoid of mammalian herbivores. The impacts of rabbits on indigenous ecosystems are well studied; notably, they cause dramatic changes in plant communities and promote soil ero...
10.1098/rsbl.2015.0408
20682533
Sleep and hypertension.
Ambulatory BP studies indicate that even small increases in BP, particularly nighttime BP levels, are associated with significant increases in cardiovascular morbidity and mortality. Accordingly, sleep-related diseases that induce increases in BP would be anticipated to substantially affect cardiovascular risk. Both sl...
10.1378/chest.09-2954
12527381
The transmembranous domain of CD40 determines CD40 partitioning into lipid rafts.
Stimulation of CD40 has been previously shown to result in a release of ceramide in small sphingolipid-enriched rafts in the cell membrane [Grassmé et al., J. Immunol. 168 (2002) 298-307]. Those rafts fused to larger signaling platforms that served to cluster CD40. Here, we defined molecular mechanisms of CD40 clusteri...
10.1016/s0014-5793(02)03784-5
7015599
Pathogenesis and prevention of graft arteriosclerosis in an experimental heart transplant model.
Accelerated graft arteriosclerosis is a major cause of death in human heart transplantation. Despite many investigations, the pathogenesis of this disease remains undetermined and its control inadequate. In this study using a rat heart transplant model and cyclosporin A, a new immunosuppressant, acute rejection was pre...
10.1097/00007890-198101000-00010
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SODA-VEC Clean Dataset

This is a cleaned and filtered version of the SODA-VEC dataset, containing high-quality biomedical title-abstract pairs from PubMed Central (PMC) articles.

Dataset Overview

  • Total examples: 26,573,900
  • Training set: 26,473,900 examples (99.6%)
  • Validation set: 50,000 examples (0.2%)
  • Test set: 50,000 examples (0.2%)

Quality Filtering Applied

This dataset has been processed with the following quality filters:

Abstract Length Filtering

  • Minimum length: 128 characters
  • Maximum length: 6,000 characters
  • Rationale: Removes fragments and overly long texts while preserving scientific abstracts

Retention Statistics

  • Original dataset: ~26.6M examples
  • After filtering: 26,573,900 examples
  • Retention rate: ~99.7%

Content Statistics (sample):

  • Title length: ~100 ± 50 chars
  • Abstract length: ~1,300 ± 600 chars
  • Title range: 10-500 chars
  • Abstract range: 128-6,000 chars

Length Distributions

Length Distributions

The dataset shows well-balanced length distributions:

  • Title lengths: Centered around 100 characters with good variance
  • Abstract lengths: Normally distributed around 1,300 characters
  • Quality filtering: Clearly removes outliers while preserving natural variation

Length Statistics

Data Fields

Each example contains:

  • title (string): The title of the scientific article
  • abstract (string): The abstract of the scientific article
  • pmcid (string): PubMed Central ID for the article

Intended Use

This dataset is designed for:

Primary Applications

  • Scientific text embeddings: Training domain-specific embedding models
  • Biomedical NLP: Fine-tuning language models on scientific literature
  • Semantic similarity: Learning representations for scientific text matching
  • Information retrieval: Building search systems for biomedical literature

Research Applications

  • Representation learning for scientific texts
  • Cross-modal learning (title-abstract relationships)
  • Domain adaptation for biomedical language models
  • Evaluation of scientific text understanding systems

Data Source & Methodology

Original Dataset

Based on the SODA-VEC dataset from PubMed Central articles.

Processing Pipeline

  1. Data loading: Combined train/validation/test splits from original dataset
  2. Quality filtering: Applied length-based filters to ensure high-quality pairs
  3. Split creation: Created new balanced train/validation/test splits
  4. Validation: Verified data integrity and distribution balance

Quality Assurance

  • Length distribution analysis
  • Duplicate detection and removal
  • Content quality validation
  • Statistical validation of splits

Usage Example

from datasets import load_dataset

# Load the dataset
dataset = load_dataset("EMBO/soda-vec-data-full_pmc_title_abstract")

# Access different splits
train_data = dataset["train"]
val_data = dataset["validation"] 
test_data = dataset["test"]

# Example usage
for example in train_data.take(1):
    print(f"Title: {example['title']}")
    print(f"Abstract: {example['abstract']}")
    print(f"PMC ID: {example['pmcid']}")

Citation

If you use this dataset in your research, please cite the original SODA-VEC paper:

@article{soda-vec-2024,
  title={SODA-VEC: Training Vector Representations of Scientific Literature},
  author={...},
  journal={...},
  year={2024}
}

License

This dataset is released under the CC-BY-4.0 license, consistent with PubMed Central's open access requirements.

Contact

For questions about this dataset, please contact the EMBO team or open an issue in the dataset repository.


Dataset processed with quality filters and balanced splits for optimal training performance.

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