metadata/model_readiness_report.csv

include_in_baseline_model,modeling_role,recommended_use,table_name
yes,primary_entity_table,"oligo-level features, IDs, modality, target, sequence, and source stratification",oligos.csv
yes,predictor_table,"PS burden, sugar chemistry, backbone, ligand/conjugation variables",chemical_modifications.csv
yes,predictor_table,"GC, Tm, off-target and sequence-derived predictors",biophysical_properties.csv
yes,predictor_table,"dose, duration, frequency, and exposure context",dose_exposure.csv
yes,assay_context_table,"model system, species, cell type, timepoint, replicate context",assays.csv
yes_label,label_or_outcome_table,"toxicity class, ALT/AST-like proxies, viability/stress/apoptosis/transcriptomic readouts",toxicity_readouts.csv
validation_only,validation_control_table,positive/negative/context control separation and control-behavior checks,controls.csv
metadata_only,transparency_metadata,exclude from model training; use for audit and source stratification,provenance.csv
no,reviewer_evidence,maps package components to official judging criteria,challenge_alignment_scorecard.csv
optional,source_specific_feature_module,optional source/module-specific predictors for sensitivity analyses and expanded modeling,rna_nanoparticle_hcc_multitarget.csv
optional,source_specific_feature_module,optional source/module-specific predictors for sensitivity analyses and expanded modeling,myc_asirna_dca_design_safety.csv
optional,source_specific_feature_module,optional source/module-specific predictors for sensitivity analyses and expanded modeling,multifunctional_hdo_delivery.csv
optional,source_specific_feature_module,optional source/module-specific predictors for sensitivity analyses and expanded modeling,scpBNA2_aso_chemistry_safety.csv
optional,source_specific_feature_module,optional source/module-specific predictors for sensitivity analyses and expanded modeling,siCyp2e1_lnp_apap_aili.csv
optional,source_specific_feature_module,optional source/module-specific predictors for sensitivity analyses and expanded modeling,ps_aso_dna_damage_response.csv
yes_high_priority_clinical_context,direct_ASO_clinical_ALT_biomarker_module,"high-priority clinical ASO module for ALT interpretation, immune activation, hepatocyte-killing context, HBsAg decline, and response stratification demonstrations",bepirovirsen_immunomodulation_alt.csv
optional_context_sensitivity_analysis,supporting_ASO_chemistry_systemic_safety_module,"use for ASO modification, systemic organ distribution, kidney uptake, PD duration, and liver-safety comparison sensitivity analyses",sna_aso_kidney_systemic_safety.csv
optional_delivery_feature_module,supporting_LNP_delivery_safety_module,"use for LNP formulation variables, endosomal escape, RNA delivery efficacy, ED50 improvement context, and liver-toxicity-safe delivery features",polyamine_plnp_rna_delivery_safety.csv
yes_high_priority_safety_module,direct_ASO_multiomics_safety_module,"high-priority ASO safety module for modeling toxic vs non-toxic ASO separation, RNA/protein off-target discordance, time-resolved safety signatures, and ALT-linked risk",aso_multiomics_time_resolved_safety.csv
yes_high_priority_preclinical_module,direct_GalNAc_siRNA_preclinical_safety_module,"high-priority GalNAc-siRNA preclinical toxicology module for off-target filtering, tissue distribution, species relevance, platform effects, reversibility, cytokine/complement/genotoxicity checks",sln360_galnac_sirna_preclinical_toxicology.csv
optional_delivery_liver_injury_module,supporting_siRNA_liver_injury_delivery_module,"use for targeted siRNA nanoparticle delivery, Kupffer-cell uptake, inflammatory liver injury, BRCC3/NLRP1 mechanism, and liver-injury rescue context",kupffer_biomimetic_sirna_srli.csv
optional_liver_ASO_mechanism_module,supporting_liver_ASO_splice_switching_module,"use for splice-switching ASO design, liver/HCC ASO efficacy, exon-skipping dose context, non-RNase-H mechanism, and epigenetic pathway readouts",ezh2_exon_skipping_hcc_aso.csv
optional_delivery_distribution_module,supporting_extrahepatic_HDO_delivery_module,"use for oligo biodistribution and tissue-specific exposure modeling beyond liver, including HDO vs parent ASO potency and systemic regimen effects",systemic_hdo_drg_sciatic_delivery.csv
optional_liver_fibrosis_RNA_axis_module,supporting_RNA_perturbation_liver_fibrosis_module,"use for HSC activation, ferroptosis, lncRNA/miRNA/GPX4 axis, fibrosis marker logic, and ALT/AST/HYP liver-injury context",xist_hsc_ferroptosis_fibrosis.csv
optional_direct_liver_siRNA_module,direct_GalNAc_siRNA_MASH_safety_module,"use for CIDEB knockdown, GalNAc hepatocyte delivery, isoGNA/off-target mitigation, steatosis/fibrosis benefit, and no-observed-toxicity context",galnac_sicidEB_mash_safety.csv
optional_cross_organ_ASO_safety_module,supporting_ASO_structure_toxicity_module,"use for ASO chemistry, late-onset toxicity, 5prime-CP/2prime-OMe gap modification, p53/paraspeckle stress, and knockdown-preservation tradeoffs",aso_late_onset_neurotox_chemical_modifications.csv
optional_direct_liver_siRNA_module,direct_GalNAc_siRNA_MASLD_liver_homeostasis_module,"use for CEBPB knockdown, HFD/MASLD stress, steatosis/metabolic/liver-function readouts, and ALT/AST unchanged safety context",galnac_sicebpb_masld_liver_homeostasis.csv
optional_delivery_module,supporting_alternative_ODN_delivery_chemistry_module,"use for cellular uptake, thiol-exchange dependence, cytotoxicity, and liver-distribution context outside GalNAc/LNP platforms",trivalent_disulfide_odn_delivery.csv
optional_liver_injury_mechanism_module,supporting_MASH_macrophage_pyroptosis_module,"use for Ox-mtDNA, mPTP, ITPR3/Ca2+/NLRP3, macrophage pyroptosis, ALT/AST, and MASH progression context",mptp_oxmtdna_mash_pyroptosis.csv
optional_direct_liver_siRNA_module,direct_siRNA_liver_fibrosis_rescue_module,"use for NG2/CSPG4 expression, Cspg4 siRNA rescue, myofibroblast activation, collagen/fibrosis, ALT/AST, steatosis and inflammation context",ng2_cspg4_sirna_liver_fibrosis.csv
optional_delivery_biodistribution_module,supporting_LNP_biodistribution_liver_detargeting_module,"use for LNP nucleic-acid delivery, in vivo screening, tumor delivery versus liver hepatocyte off-target delivery, and delivery-related safety context",hnscc_lnp_liver_detargeting.csv