| dataset_evidence,demonstration_file,judging_criterion,notes,status |
| "oligos, chemistry, dose/exposure, assays, toxicity_readouts, controls, generated_records, source-specific modules, and model-readiness fields",model_readiness_report.csv; validation_summary.csv; toxicity_readouts.csv,Ability to Solve the Challenge,"Dataset is structured for in silico oligo-toxicity modeling with predictors, readouts, labels, controls, and source/module stratification.",demonstrated |
| "information_gap_map.csv maps each source/module to public-domain gaps such as sequence toxicity, PS burden, delivery targeting, human liver systems, liver injury context, DNA damage response, and carrier-free RNAi platforms",information_gap_map.csv,Potential Impact,Emphasizes gaps not well covered by single public datasets.,demonstrated |
| "validation_summary.csv, control profiles, source roles, provenance labels, assumptions, schema/data dictionary, and generated QC fields",validation_summary.csv; data_dictionary.csv; assumptions.csv; controls.csv,Feasibility and Rigor,Reviewer-facing checks are generated with every run.,demonstrated |
| "single-file generator, fixed random seed, manifest, reproducibility_manifest.json, source_triage_log.csv, provenance.csv, assumptions.csv, license/readme",reproducibility_manifest.json; dataset_manifest.json; source_triage_log.csv; provenance.csv,Transparency and Reproducibility,All generated values remain synthetic/harmonized and labeled by provenance.,demonstrated |
| v1.0 adds GalNAc-siRNA liver modules for CIDEB/MASH and CEBPB/MASLD plus ASO toxicity-mitigation chemistry,galnac_sicidEB_mash_safety.csv; galnac_sicebpb_masld_liver_homeostasis.csv; aso_late_onset_neurotox_chemical_modifications.csv,Ability to Solve the Challenge,"Adds direct liver-targeted siRNA target-engagement, off-target/safety, disease-stress, and liver-function readouts.",demonstrated |
| "v1.0 expands public-domain gaps around MASH/MASLD GalNAc-siRNA safety, ASO late-onset toxicity, and non-LNP/non-GalNAc ODN delivery chemistry",information_gap_map.csv; source_triage_log.csv,Potential Impact,Broader coverage improves model stress testing and mechanistic diversity.,demonstrated |
| v1.0 tracks direct vs supporting vs deferred papers and labels non-liver/CNS toxicity modules as cross-organ safety context,source_triage_log.csv; validation_summary.csv; data_dictionary.csv,Feasibility and Rigor,Avoids adding unrelated NSCLC survival marker study into the core generator.,demonstrated |
| "v1.0 adds MASH macrophage pyroptosis, Cspg4/NG2 siRNA fibrosis, and LNP liver de-targeting modules",mptp_oxmtdna_mash_pyroptosis.csv; ng2_cspg4_sirna_liver_fibrosis.csv; hnscc_lnp_liver_detargeting.csv,Ability to Solve the Challenge,"Adds additional liver-injury mechanisms, direct siRNA fibrosis rescue context, and delivery-biodistribution controls.",demonstrated |
| v1.0 cleans up redundant Fig. 5 files and replaces weak duplicate/similar plots with a control/readout heatmap,figures/fig05a_control_readout_heatmap.png; validation_summary.csv; dataset_manifest.json,Feasibility and Rigor,Improves reviewer-facing figure purpose and removes a duplicated compact-overview figure.,demonstrated |
| "v1.0 continues explicit source triage, deferring review-only sources while documenting why",source_triage_log.csv; information_gap_map.csv; dataset_manifest.json,Transparency and Reproducibility,Review-only nanoparticle and ASO evolution papers are tracked but not converted into noisy row-level modules.,demonstrated |
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