validation_summary.csv

metric,status,table_name,value
row_count,ok,sources.csv,144
row_count,ok,controls.csv,161
row_count,ok,oligos.csv,1120
row_count,ok,chemical_modifications.csv,1120
row_count,ok,biophysical_properties.csv,1120
row_count,ok,dose_exposure.csv,1120
row_count,ok,nanoparticle_delivery.csv,1120
row_count,ok,rna_payload_systems.csv,1120
row_count,ok,lipid_homeostasis.csv,1120
row_count,ok,epigenetic_liver_context.csv,1120
row_count,ok,angptl3_liver_safety.csv,1120
row_count,ok,pnpla3_precision_context.csv,1120
row_count,ok,extrahepatic_delivery.csv,1120
row_count,ok,personalized_aso_workflow.csv,1120
row_count,ok,aso_metabolic_nafld_context.csv,1120
row_count,ok,sequence_modification_toxicity.csv,1120
row_count,ok,hsd17b13_rapirosiran_clinical_pd.csv,1120
row_count,ok,hbv_rnai_escplus_safety.csv,1120
row_count,ok,zilebesiran_raas_safety.csv,1120
row_count,ok,sirna_bulge_offtarget_tolerance.csv,1120
row_count,ok,fbll1_hcc_spatial_oncogenic_context.csv,1120
row_count,ok,galnac_lnp_mkk4_liver_regeneration.csv,1120
row_count,ok,ogt_sev_lsec_masld_context.csv,1120
row_count,ok,malat1_hbv_hcc_aso_context.csv,1120
row_count,ok,cd133_masld_hcc_sirna_context.csv,1120
row_count,ok,galnac_rbc_ev_liver_delivery.csv,1120
row_count,ok,meldplus_cirrhosis_risk_context.csv,1120
row_count,ok,formononetin_aldh2_nrf2_ald_context.csv,3
row_count,ok,hnp_hoxb7_tamoxifen_nanoparticle_context.csv,3
row_count,ok,pmevl_sev_rna_loading_pcsk9_context.csv,17
row_count,ok,preclinical_oligo_safety_assessment.csv,26
row_count,ok,ifna_disulfidptosis_hcc_context.csv,44
row_count,ok,galnac_sirna_nonclinical_safety.csv,319
row_count,ok,inclisiran_fh_realworld_context.csv,33
row_count,ok,reviewed_not_encoded_sources.csv,1
row_count,ok,galnac_liver_delivery_review_context.csv,196
row_count,ok,sirna_pharmacology_clinical_development_context.csv,4
row_count,ok,aso_gapmer_hepatotoxicity_screening.csv,43
row_count,ok,ago1_lnp_aso_endothelial_liver_vascular_context.csv,4
row_count,ok,assays.csv,5600
row_count,ok,toxicity_readouts.csv,16800
row_count,ok,generated_records.csv,17920
row_count,ok,assumptions.csv,76
row_count,ok,provenance.csv,144
row_count,ok,data_dictionary.csv,259
hepatotoxicity_label_count,ok,toxicity_readouts.csv,low:1712
hepatotoxicity_label_count,ok,toxicity_readouts.csv,moderate:4505
hepatotoxicity_label_count,ok,toxicity_readouts.csv,high:10583
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_VEHICLE_MOCK
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_LOW_RISK_OLIGO
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSIRAN
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_HUMAN_LIVER_SPHEROID_TOLERATED
control_present_in_oligos,ok,oligos.csv,CTRL_POS_HIGH_PS_HIGH_DOSE
control_present_in_oligos,ok,oligos.csv,CTRL_POS_HIGH_OFFTARGET
control_present_in_oligos,ok,oligos.csv,CTRL_POS_TRANSCRIPTOMIC_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_POS_LNA_GAPMER_HIGH_RISK
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_TARGETED_LNP_ASGPR_SAFE_WINDOW
control_present_in_oligos,ok,oligos.csv,CTRL_POS_DELIVERY_RELATED_NP_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_BALANCED_HYBRID_RNA_LNP
control_present_in_oligos,ok,oligos.csv,CTRL_POS_IMMUNE_ACTIVATING_RNA_LNP_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_APOB_ASO_LOW_LIPID_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_POS_APOB_ASO_LIPID_EXPORT_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_SULT1B1_SIRNA_LIPID_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_POS_MASLD_EPIGENETIC_LIPID_ACCUMULATION
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_ANGPTL3_SIRNA_LIVER_SAFETY
control_present_in_oligos,ok,oligos.csv,CTRL_POS_ANGPTL3_ASO_HEPATIC_FAT_ALT_SIGNAL
control_present_in_oligos,ok,oligos.csv,CTRL_POS_PNPLA3_I148M_HOMOZYGOUS_LIPID_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_PNPLA3_SIRNA_HOMOZYGOTE_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PNPLA3_HETEROZYGOUS_UNCERTAIN_RESPONSE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_CHOLESTEROL_SIRNA_MUSCLE_TOLERATED
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_EXTRAHEPATIC_SIRNA_LIVER_EXPOSURE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_PERSONALIZED_ASO_ACCEPTABLE_SAFETY_PROFILE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_CUSTOM_ASO_TOX_WORKFLOW
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_GALNAC_ASO_NAFLD_TARGETED_LIVER_SAFE_WINDOW
control_present_in_oligos,ok,oligos.csv,CTRL_POS_HIGH_AFFINITY_GAPMER_HEPATOTOX_SEQUENCE_MOTIF
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ASO_TYPE_I_IFN_OFFTARGET
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_LNA_GAPMER_SEQUENCE_REDESIGN_LOW_TOX
control_present_in_oligos,ok,oligos.csv,CTRL_POS_LNA_GAPMER_SEQUENCE_PATTERN_HIGH_TOX
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_DISTANCE_LIMITED_SEQUENCE_TOX_PREDICTION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_HSD17B13_RAPIROSIRAN_NO_DILI_PD
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_HSD17B13_HEPATITIS_E_CONFOUNDED_ALT_AST
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_HSD17B13_PLACEBO_MASH_ALT_AST_REFERENCE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_VIR2218_ESCPLUS_LOW_ALT
control_present_in_oligos,ok,oligos.csv,CTRL_POS_ALNHBV_SEED_OFFTARGET_ALT
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_VIR2218_CHBV_HBSAG_REDUCTION
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_ZILEBESIRAN_GALNAC_AGT_PLATFORM_LOW_HEPATIC_INJURY
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ZILEBESIRAN_RAAS_HYPERKALEMIA_RENAL_MONITORING
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ZILEBESIRAN_LONG_PD_ENDOSOMAL_DEPOT
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_TTR_GALNAC_SIRNA_BULGE14_ACTIVE_LOW_TOX
control_present_in_oligos,ok,oligos.csv,CTRL_POS_TERMINAL_BULGE_OFFTARGET_REPRESSION_RISK
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_SEED_REGION_BULGE_ACTIVITY_LOSS
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_FBLL1_HIGH_HCC_MALIGNANT_STATE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_FBLL1_SIRNA_KNOCKDOWN_HCC_GROWTH_SUPPRESSION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_FBLL1_CMYC_EGFR_MAPK_ACTIVATION
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_GALNAC_LNP_SIMKK4_BIOCOMPATIBLE_LOW_HEMOLYSIS
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_LNP_SIMKK4_ACLF_REGENERATION
control_present_in_oligos,ok,oligos.csv,CTRL_POS_CCL4_PHX_ACLF_INJURY_CONTEXT
control_present_in_oligos,ok,oligos.csv,CTRL_POS_OGT_SEV_LSEC_CAPILLARIZATION_MASLD
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_OGT_KNOCKDOWN_SEV_REDUCED_CAPILLARIZATION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_BAGN_OGLCNAC_INHIBITOR_MASLD_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_POS_HBX_MALAT1_IGF2BP3_HCC_ONCOGENIC_STATE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_ASO_MALAT1_HBV_HCC_TUMOR_SUPPRESSION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_MALAT1_M6A_IGF2BP3_SHUTTLING
control_present_in_oligos,ok,oligos.csv,CTRL_POS_CD133_CSC_MASLD_HCC_MKI_RESISTANCE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_VNP_SICD133_MKI_TUMOR_SUPPRESSION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_CD133_MYH9_BCATENIN_STEMNESS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_GALNAC_RBC_EV_HEPATOCYTE_TARGETED_SAFE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_RBC_EV_GALNAC_MIR155_ASO_ALF_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_RBC_EV_PJ34_NAFLD_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_RBC_EV_RAB7_SIRNA_PJ34_HCC
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_MELD_PLUS_HIGH_RISK_CIRRHOSIS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_MELD_PLUS_LOW_RISK_CIRRHOSIS
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_MELD_PLUS_EMR_VARIABLES
control_present_in_oligos,ok,oligos.csv,CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDRIAL_STRESS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOPROTECTION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_SIGNAL
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN_COTREATMENT
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE_ENDOSOMAL_ESCAPE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_PMEVL_SEV_SIPCSK9_LOW_SYSTEMIC_TOX
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PMEVL_N_MYRISTOYLATION_RNA_LOADING
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PMEVL_ERK_AMPK_ANXA2_ESCRT_MECHANISM
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PRECLINICAL_OLIGO_SAFETY_FRAMEWORK
control_present_in_oligos,ok,oligos.csv,CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RISK
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_HYBRIDIZATION_OFFTARGET_SCREENING
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_PRODUCTIVE_UPTAKE_HEPATOCYTE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_CMAX_COMPLEMENT_COAGULATION_MONITORING
control_present_in_oligos,ok,oligos.csv,CTRL_POS_IFNA_DISULFIDPTOSIS_HCC
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_DPEN_DISULFIDPTOSIS_RESCUE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_SLC7A11_KD_IFNA_AGGRAVATION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_IFNA_ISG_B2M_USP18_PSME1
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_GALNAC_ESC_SIRNA_PLATFORM_LOW_TOX
control_present_in_oligos,ok,oligos.csv,CTRL_POS_GALNAC_SIRNA_SEED_OFFTARGET_RAT_HEPATOTOX
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_SIRNA_LIVER_KIDNEY_RES_DISTRIBUTION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_INCLISIRAN_FH_LDL_PWV_RESPONSE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALWORLD
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_ASGPR_LIVER_DELIVERY_REVIEW
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_ASO_HEPATOCYTE_UPTAKE_POTENCY
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_SIRNA_ESCPLUS_SEED_SAFETY
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GALNAC_REVERSIR_REVERSAL_SAFETY
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHANISM
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_SIRNA_PKPD_BARRIERS
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGET_SCREENING
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_APPROVED_GALNAC_SIRNA_CLINICAL_TRANSLATION
control_present_in_oligos,ok,oligos.csv,CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_LNA_GAPMER_SELECTIVE_LOW_HEPATOX
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ACUTE_MOUSE_ASO_HEPATOX_SCREEN
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_TRANSCRIPTOME_WIDE_OTE_SELECTIVITY
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLAMMATION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVER_FUNCTION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_EC_HEPATOCYTE_PARACRINE_METABOLISM
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTION_POMPE
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GYS1_ASO_ERT_COMBINATION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_GYS1_GYS2_ISOFORM_SPECIFICITY
control_present_in_oligos,ok,oligos.csv,CTRL_POS_DDC_CHOLESTATIC_LIVER_INJURY_ALT_ALP_BILI
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_CHOLESTASIS_RECOVERY_R15_RESOLUTION
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_CX3CL1_CX3CR1_MACROPHAGE_RECRUITMENT
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_NFYA_TGFB1_CHOLANGIOCYTE_FIBROSIS
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_PCDHA11_AMNA_2255_LOW_REVERSIBLE_LIVER_SIGNAL
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_PCDHA11_AMNA_3319_LOW_OFFTARGET_LIVER_SIGNAL
control_present_in_oligos,ok,oligos.csv,CTRL_POS_PCDHA11_AMNA_3969_SEQUENCE_DEPENDENT_LIVER_INJURY
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PCDHA11_AMNA_OFFTARGET_MICROARRAY_SCREEN
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PCDHA11_KO_TARGET_SPECIFICITY_APOPTOSIS
control_present_in_oligos,ok,oligos.csv,CTRL_POS_PS_ASO_DDR_HIGH_CONDENSATE
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_PO_ASO_LOW_DDR_NO_PS_BODY
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ASO_REPAIR_PROTEIN_BINDING
control_present_in_oligos,ok,oligos.csv,CTRL_NEG_SIRUBICON_ROS_GALNAC_LIVER_FUNCTION_IMPROVED
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_ROS_GALNAC_HEPATOCYTE_TARGETING
control_present_in_oligos,ok,oligos.csv,CTRL_CONTEXT_PEI_NANOCARRIER_SAFETY_MONITORING
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_SCPBNA2_ASO_LOW_HEPATOTOX_RETAINED_KD
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_LNA_BNA_ASO_HEPATOTOX_PARENT
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_REDUCED_PS_PO_LINKAGE_LOWER_ACTIVITY_RISK
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_SICYP2E1_LNP_APAP_ALT_AST_RESCUE
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_APAP_AILI_UNTREATED_HIGH_ALT_AST
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_DELAYED_SICYP2E1_LIMITED_EARLY_RESCUE_RECOVERY
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_CHOLESTEROL_NANP_HEPATOCYTE_UPTAKE
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_TRIGALNAC_NANP_WEAK_ASGPR_UPTAKE
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_NANP_KUPFFER_SCAVENGER_ASSOCIATION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_RNA_NP_NON_TARGETED_LOW_OFFTARGET
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_RNA_NP_MULTITARGET_HCC_ACTIVITY
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_RNA_NP_VERO_DOSE_WINDOW
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_DCA_ASIRNA_NO_VISIBLE_TOX_DURABLE_KD
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_ASIRNA_SEED_OFFTARGET_REDUCTION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_HEAVY_2F_PS_MODIFICATION_OFFTARGET_RISK
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_MULTIFUNCTIONAL_HDO_DELIVERY
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_HDO_SCRAMBLED_CONTROL
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_AGT_GALNAC_SIRNA_SAFE_CANDIDATE
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_AGT_SIRNA_OFFTARGET_LIVER_KIDNEY_SIGNAL
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_ZILEBESIRAN_LIKE_COMPARATOR
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_CPG_ODN_MACROPHAGE_APAP_PROTECTION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_CPG_ODN_ACOD1_SIRNA_LOSS_OF_PROTECTION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_ERBB2_APTAMER_PET_PK_BIODISTRIBUTION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_PARENT_LNA_GAPMER_ALT_SIGNAL
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_BROTHERS_ASO_PNA_ALT_MITIGATION
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_APOC3_GALNAC_SIRNA_LONG_ACTING_SAFE
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_GALNAC_SIRNA_LCMS_BIOANALYSIS
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_ORAL_MIR29A_FIBROSIS_NA
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_LNP_CRISPR_HAO1_NO_LIVER_TOX_LONG_TERM
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_PS_LNA_ASO_INTERNALIZATION_LOW_TOX
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_ESCPLUS_SEED_DESTABILIZED_LOW_ALT
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_ESC_PARENT_SEED_OFFTARGET_ALT
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_LNA_PTTE_BACKBONE_ACTIVITY
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_FXR_G0S2_DILI_RESCUE
control_present_in_oligos,warning_missing,oligos.csv,CTRL_POS_HIGH_AFFINITY_GAPMER_RNASEH1_LONG_PREMRNA_ALT
control_present_in_oligos,warning_missing,oligos.csv,CTRL_NEG_MOE_OR_RNASEH1_ATTENUATED_GAPMER
control_present_in_oligos,warning_missing,oligos.csv,CTRL_QC_FREE_ASO_PAYLOAD_LCMS_SPECIFICITY
control_present_in_oligos,warning_missing,oligos.csv,CTRL_CONTEXT_PUM1_EXOSOME_HSC_FIBROSIS_AXIS
human_relevant_assay_fraction,ok,assays.csv,0.5813
new_table,ok,ago1_lnp_aso_endothelial_liver_vascular_context.csv,4
source_added,ok,sources.csv,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025
controls_added,ok,controls.csv,4
preprint_caution,ok,ago1_lnp_aso_endothelial_liver_vascular_context.csv,preprint_supporting_context_not_definitive
new_table,ok,gys1_pompe_aso_srt_context.csv,4
source_added,ok,sources.csv,WEISS_GYS1_ASO_POMPE_PREPRINT_2024
controls_added,ok,controls.csv,4
preprint_caution,ok,gys1_pompe_aso_srt_context.csv,preprint_supporting_context_not_direct_hepatotoxicity
phase2_scoring_alignment,ok,gys1_pompe_aso_srt_context.csv,negative_controls_translatability_safety_monitoring_documentation
new_table,ok,cholangiocyte_cholestasis_recovery_context.csv,21
source_added,ok,sources.csv,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025
controls_added,ok,controls.csv,4
phase2_alignment,ok,cholangiocyte_cholestasis_recovery_context.csv,liver_endpoint_diversity_cholestasis_fibrosis_macrophage_translatability
figure_file_count,ok,figures,10
new_table,ok,pcdha11_amna_aso_hepatotoxicity.csv,35
source_added,ok,sources.csv,KANDA_PCDHA11_AMNA_ASO_2024
controls_added,ok,controls.csv,5
direct_hepatotoxicity_alignment,ok,pcdha11_amna_aso_hepatotoxicity.csv,dose_sequence_dependence_reversibility_AST_ALT_ALP_offtarget_controls
copyright_safety,ok,pcdha11_amna_aso_hepatotoxicity.csv,no_source_figures_tables_sequences_or_long_text_redistributed
new_table,ok,ps_aso_dna_damage_response.csv,27
new_table,ok,sirubicon_ros_galnac_mash_delivery.csv,11
source_added,ok,sources.csv,HJELMGREN_PS_ASO_DDR_2026
source_added,ok,sources.csv,LAN_SIRUBICON_ROS_GALNAC_MASH_2025
controls_added,ok,controls.csv,6
triage_decision,ok,uploaded_pdfs,added_2_modules_deferred_2_duplicate_1
copyright_safety,ok,all_tables,no_source_figures_tables_sequences_or_long_text_redistributed
new_table,ok,scpBNA2_aso_chemistry_safety.csv,28
new_table,ok,siCyp2e1_lnp_apap_aili.csv,17
new_table,ok,lipid_nanp_liver_cell_targeting.csv,15
fig05_redesign,ok,figures,compact_overview_negative_positive_context_panels
fig07_redesign,ok,figures,top_and_additional_modality_panels
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2
deferred_source,ok,uploaded_pdfs,AUCHYNNIKAVA_FOLATE_MSNA_2025_deferred_delivery_biodistribution_context
deferred_source,ok,uploaded_pdfs,ZHANG_BERBERINE_GEFITINIB_DILI_2025_deferred_non_oligo_DILI_context
new_table,ok,rna_nanoparticle_hcc_multitarget.csv,14
new_table,ok,myc_asirna_dca_design_safety.csv,10
new_table,ok,multifunctional_hdo_delivery.csv,4
new_judging_criteria_table,ok,challenge_alignment_scorecard.csv,10
new_judging_criteria_table,ok,information_gap_map.csv,144
new_judging_criteria_table,ok,model_readiness_report.csv,15
triage_decision,ok,uploaded_pdfs,added_3_supporting_modules_deferred_2
deferred_source,ok,uploaded_pdfs,KUMAGAI_SCPBNA2_PURINE_SYNTHESIS_2025_deferred_because_direct_scpBNA2_hepatotoxicity_already_encoded
deferred_source,review_needed,uploaded_pdfs,BJD_BMP1_SHRNA_AAV_CCL4_FIBROSIS_CONTEXT_deferred_due_to_limited_text_extraction_quality
new_table,ok,agt_galnac_sirna_development_toxicology.csv,80
new_table,ok,cpg_odn_apap_macrophage_immunomodulation.csv,60
new_table,ok,erbb2_aptamer_pet_pk.csv,55
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2_context_sources
deferred_source,ok,uploaded_pdfs,XI_HCC_CHROMATIN_DGAT1_SIRNA_2025_deferred_context_only
deferred_source,ok,uploaded_pdfs,LI_AIH_CERNA_NETWORK_2022_deferred_context_only
judging_alignment,ok,agt_galnac_sirna_development_toxicology.csv,directly_supports_ability_to_solve_feasibility_rigor_potential_impact
new_table,ok,brothers_aso_pna_toxicity_mitigation.csv,120
new_table,ok,apoc3_galnac_sirna_sar_safety.csv,160
new_table,ok,galnac_sirna_lcms_bioanalysis.csv,150
new_table,ok,oral_mir29a_liver_fibrosis_na.csv,120
triage_decision,ok,uploaded_pdfs,added_4_modules_deferred_1_context_source
deferred_source,ok,uploaded_pdfs,LU_GT_MULTI_SIRNA_HCC_2025_deferred_context_only
judging_alignment,ok,brothers_aso_pna_toxicity_mitigation.csv,directly_supports_ability_to_solve_feasibility_rigor_potential_impact
judging_alignment,ok,galnac_sirna_lcms_bioanalysis.csv,supports_transparency_reproducibility_and_measurement_rigor
new_table,ok,lnp_crispr_hao1_ph1_safety.csv,20
new_table,ok,ps_lna_hiv_aso_internalization_toxicity.csv,15
triage_decision,ok,uploaded_pdfs,added_2_modules_deferred_3_context_sources
deferred_source,ok,uploaded_pdfs,XU_FGF21_MAPK1_DAIRY_KETOSIS_SIRNA_2025_deferred_context_only
deferred_source,ok,uploaded_pdfs,ELGHAZZI_GENE_SILENCING_GI_GU_TUMORS_REVIEW_2025_deferred_review_only
deferred_source,ok,uploaded_pdfs,YANG_PIRNA_CANCER_DIAGNOSTIC_THERAPEUTIC_REVIEW_2026_deferred_review_only
judging_alignment,ok,lnp_crispr_hao1_ph1_safety.csv,supports_feasibility_rigor_transparency_liver_delivery_safety
judging_alignment,ok,ps_lna_hiv_aso_internalization_toxicity.csv,supports_ASO_chemistry_uptake_tolerability_context
new_table,ok,escplus_seed_pairing_safety_mechanism.csv,25
new_table,ok,lna_phosphothiotriester_splice_switching.csv,35
new_table,ok,fxr_jnk_g0s2_dili_context.csv,18
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_1_context_source_skipped_1_duplicate
duplicate_source,ok,uploaded_pdfs,gkac539_duplicate_of_SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIRNA_2022_not_counted_twice
deferred_source,ok,uploaded_pdfs,JEON_COP1_HCC_LIPID_STEMNESS_SIRNA_2026_deferred_context_only
judging_alignment,ok,escplus_seed_pairing_safety_mechanism.csv,directly_supports_ability_to_solve_potential_impact_rigor_transparency
judging_alignment,ok,lna_phosphothiotriester_splice_switching.csv,supports_chemistry_design_space_PS_reduction_backbone_alternatives
judging_alignment,ok,fxr_jnk_g0s2_dili_context.csv,supports_liver_pathway_mechanistic_covariates_ALT_AST_metabolic_disorder
new_table,ok,gapmer_rnaseh1_long_premrna_hepatotox.csv,6
new_table,ok,aoc_free_aso_payload_bioanalysis.csv,5
new_table,ok,pum1_exosome_masld_hsc_fibrosis.csv,6
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2_context_sources
deferred_source,ok,uploaded_pdfs,ZHU_HMMR_HCC_4MU_SIRNA_2026_deferred_context_only
deferred_source,ok,uploaded_pdfs,GHOLIKHANI_APTAMER_BREAST_CANCER_REVIEW_2022_deferred_review_context_only
judging_alignment,ok,gapmer_rnaseh1_long_premrna_hepatotox.csv,directly_supports_ability_to_solve_feasibility_rigor_and_toxicity_mechanism_transparency
judging_alignment,ok,aoc_free_aso_payload_bioanalysis.csv,supports_transparency_reproducibility_PK_PD_measurement_quality_and_exposure_QC
judging_alignment,ok,pum1_exosome_masld_hsc_fibrosis.csv,supports_potential_impact_and_liver_fibrosis_lipotoxicity_context
new_table,ok,bepirovirsen_immunomodulation_alt.csv,6
new_table,ok,sna_aso_kidney_systemic_safety.csv,6
new_table,ok,polyamine_plnp_rna_delivery_safety.csv,6
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2_context_sources
deferred_source,ok,uploaded_pdfs,TAKENOYA_GALP_HFD_LIVER_TRANSCRIPTOME_METABOLOME_2023_deferred_not_oligo_specific
deferred_source,ok,uploaded_pdfs,SHEVELEV_SIRNA_THERAPEUTICS_REVIEW_2025_deferred_review_only
judging_alignment,ok,bepirovirsen_immunomodulation_alt.csv,directly_supports_clinical_ASO_ALT_response_biology_and_hepatocyte_killing_context
judging_alignment,ok,sna_aso_kidney_systemic_safety.csv,supports_ASO_chemistry_safety_and_systemic_delivery_rigor
judging_alignment,ok,polyamine_plnp_rna_delivery_safety.csv,supports_RNA_delivery_safety_endosomal_escape_and_liver_toxicity_safe_LNP_design
new_table,ok,aso_multiomics_time_resolved_safety.csv,36
new_table,ok,sln360_galnac_sirna_preclinical_toxicology.csv,7
new_table,ok,kupffer_biomimetic_sirna_srli.csv,6
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2_context_sources
deferred_source,ok,uploaded_pdfs,LI_PKHD1_ARPKD_ASO_SPLICE_RESCUE_2023_deferred_low_direct_hepatotoxicity_signal
deferred_source,ok,uploaded_pdfs,JIA_ATP7B_WILSON_MICROARRAY_DIAGNOSTIC_2022_deferred_diagnostic_not_therapeutic_oligo_toxicity
judging_alignment,ok,aso_multiomics_time_resolved_safety.csv,directly_supports_ASO_safety_rigor_with_RNAseq_proteomics_time_course_and_ALT_classification
judging_alignment,ok,sln360_galnac_sirna_preclinical_toxicology.csv,directly_supports_GalNAc_siRNA_preclinical_safety_specificity_tissue_distribution_and_reversibility
judging_alignment,ok,kupffer_biomimetic_sirna_srli.csv,supports_targeted_siRNA_delivery_and_inflammatory_liver_injury_context
new_table,ok,ezh2_exon_skipping_hcc_aso.csv,6
new_table,ok,systemic_hdo_drg_sciatic_delivery.csv,7
new_table,ok,xist_hsc_ferroptosis_fibrosis.csv,6
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2_context_sources
deferred_source,ok,uploaded_pdfs,YUAN_LIVTAC_GALNAC_PROTAC_BRD4_FIBROSIS_2025_deferred_non_oligo_GalNAc_PROTAC_context
deferred_source,ok,uploaded_pdfs,CAI_LYCIUM_POLYSACCHARIDES_ETHANOL_LIVER_INJURY_2025_deferred_non_oligo_nutraceutical_context
judging_alignment,ok,ezh2_exon_skipping_hcc_aso.csv,supports_liver_ASO_splice_switching_design_and_HCC_therapeutic_context
judging_alignment,ok,systemic_hdo_drg_sciatic_delivery.csv,supports_extrahepatic_oligo_delivery_distribution_and_potency_context
judging_alignment,ok,xist_hsc_ferroptosis_fibrosis.csv,supports_RNA_perturbation_HSC_ferroptosis_fibrosis_and_liver_injury_marker_context
new_table,ok,galnac_sicidEB_mash_safety.csv,6
new_table,ok,aso_late_onset_neurotox_chemical_modifications.csv,6
new_table,ok,galnac_sicebpb_masld_liver_homeostasis.csv,5
new_table,ok,trivalent_disulfide_odn_delivery.csv,5
triage_decision,ok,uploaded_pdfs,added_4_modules_deferred_1_NSCLC_survival_marker_study
deferred_source,ok,uploaded_pdfs,NASTASE_NSCLC_LONG_TERM_SURVIVAL_MARKERS_2022_deferred_not_oligo_not_liver_toxicity_specific
judging_alignment,ok,galnac_sicidEB_mash_safety.csv,supports_direct_liver_GalNAc_siRNA_safety_offtarget_MASH_steatosis_fibrosis_context
judging_alignment,ok,aso_late_onset_neurotox_chemical_modifications.csv,supports_cross_organ_ASO_structure_toxicity_and_chemistry_mitigation_context
judging_alignment,ok,galnac_sicebpb_masld_liver_homeostasis.csv,supports_direct_liver_GalNAc_siRNA_MASLD_homeostasis_and_ALT_AST_safety_context
judging_alignment,ok,trivalent_disulfide_odn_delivery.csv,supports_alternative_oligonucleotide_delivery_chemistry_and_liver_distribution_context
new_table,ok,mptp_oxmtdna_mash_pyroptosis.csv,5
new_table,ok,ng2_cspg4_sirna_liver_fibrosis.csv,6
new_table,ok,hnscc_lnp_liver_detargeting.csv,5
triage_decision,ok,uploaded_pdfs,added_3_modules_deferred_2_review_only_sources
deferred_source,ok,uploaded_pdfs,HUANG_NANOPARTICLE_SIRNA_ONCOLOGY_REVIEW_2022_deferred_review_only
deferred_source,ok,uploaded_pdfs,RUCHI_EVOLUTION_ASO_CHEMISTRY_DELIVERY_REVIEW_2025_deferred_review_only
fig05_cleanup,ok,figures,"removed_duplicate_or_low_value_fig05_files=fig05_control_profiles_compact_overview.png,fig05a_negative_control_profiles.png,fig05c_context_control_profiles.png"
fig05_added,ok,figures,fig05a_control_readout_heatmap.png
new_table,ok,nnmt_aso_macrophage_atherosclerosis.csv,5
new_table,ok,ty1_oral_ncrna_macrophage_delivery.csv,6
new_table,ok,dual_rgd_sirna_nanocarrier_delivery.csv,6
fig07_cleanup,ok,figures,"removed=fig07a_top_modality_risk_boxplot.png,fig07b_additional_modality_risk_boxplot.png; added fig07_modality_risk_horizontal.png and figure_label_dictionary.csv"
deferred_source,ok,uploaded_pdfs,p21 lentiviral shRNA cartilage and panduratin A small-molecule HBV deferred
new_table,ok,rpsap52_lna_gapmer_ovarian_pdox.csv,6
new_table,ok,biologics_hyb_targeted_rna_delivery.csv,7
deferred_source,ok,uploaded_pdfs,"PIKfyve/apilimod HEV, cardiac RNAi systematic review, and pelacarsen review deferred from row-level generation"
new_table,ok,cd81_galnac_sirna_malaria_protection.csv,6
new_table,ok,rbm39_hepatocyte_innate_immunity.csv,6
new_table,ok,galnac_sirna_pcsk9_liquid_phase_design.csv,6
deferred_source,ok,uploaded_pdfs,Gag.MS2 CRISPR delivery and MMDx transplant diagnostics deferred from row-level generation
new_table,ok,larp6_hsc_fibrosis_dsirna.csv,6
new_table,ok,rnai_rheostat_aav_transgene_control.csv,6
new_table,ok,galnac_sirna_offtarget_rat_hepatotoxicity.csv,6
new_table,ok,dilimap_toxpredictor_dili_toxicogenomics.csv,6
deferred_source,ok,uploaded_pdfs,Therapeutic siRNA review deferred from row-level generation; retained for final narrative/background only
new_table,ok,ro7239958_galnac_lna_aso_hbv_phase1.csv,6
new_table,ok,hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,6
new_table,ok,pcsk9_sirna_sting_cancer_immunotherapy.csv,6
new_table,ok,gys1_aso_pompe_skeletal_muscle.csv,6
deferred_source,ok,uploaded_pdfs,TOP2A HCC scRNA-seq/siRNA paper deferred from row-level generation; target-validation biology only
new_table,ok,sptlc2_lnp_sirna_mash_ceramide.csv,6
new_table,ok,pdl1_aptamer_cd47_sirna_treg_hcc.csv,6
new_table,ok,thbs1_rili_proteomics_sirna.csv,6
deferred_source,ok,uploaded_pdfs,NEDD4 and HNF4A dairy-cow ketosis papers deferred from row-level generation; mechanistic bovine siRNA context only
new_table,ok,tg_keratin_bile_acid_hepatocyte_death.csv,6
new_table,ok,trim16_yap1_nrf2_septic_liver_injury.csv,6
new_table,ok,tdev_membrane_lev_sirna_hcc_delivery.csv,6
deferred_source,ok,uploaded_pdfs,NFI/CYP primary human hepatocyte pharmacometabolism paper deferred from row-level generation; general hepatic drug metabolism context only
new_table,ok,cuproptosis_wilson_liver_injury.csv,6
new_table,ok,galnac_sirna_pbpk_pd_species_translation.csv,6
deferred_source,ok,uploaded_pdfs,HBV oligonucleotide therapy review deferred from row-level generation; useful for final narrative/background
deferred_source,ok,uploaded_pdfs,Information-theoretic microarray/PID paper deferred from core generator; possible optional notebook method later
supplemental_table,ok,supplemental_source_decisions.csv,8
supplemental_table,ok,source_corpus_access_statement.csv,1
supplemental_table,ok,galnac_sirna_risc_offtarget_mechanism.csv,7
supplemental_table,ok,approved_oligo_chemistry_landscape.csv,7
supplemental_table,ok,pnpla3_azd2693_precision_mash.csv,6
supplemental_table,ok,hsd17b13_genetics_aso_translation.csv,7
supplemental_table,ok,nat_model_selection_evidence.csv,7
supplemental_table,ok,fda_tides_2025_oligo_landscape.csv,4
supplemental_table,ok,rna_targeted_therapeutics_platform.csv,6
supplemental_pdfs_evaluated,ok,supplemental_source_decisions.csv,8
no_original_filenames,ok,supplemental_source_decisions.csv,paper_title_short_title_source_id_only
open_access_boundary,ok,source_corpus_access_statement.csv,open_access_or_freely_downloadable_PDFs_only_as_directly_processed_sources