id stringlengths 24 24 | question stringlengths 21 168 | context stringlengths 79 19.2k | answer stringclasses 2
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5314896adae131f847000001 | Is corpus callosum involved in the Mowat–Wilson syndrome? | The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung disease, genital anomalies, congenital heart disease, agenesis of the corpus callosum, and eye defects. Mowat-Wilson syndrome in a fetus with antenatal... | yes |
54d62faf3706e89528000003 | Can NXY-059 be used for treatment of acute ischemic stroke patients? | Even when the international recommendations for preclinical stroke research, the Stroke Academic Industry Roundtable (STAIR) criteria, were followed, we have still seen limited success in the clinic, examples being NXY-059 and haematopoietic growth factors which fulfilled nearly all the STAIR criteria This occurred dur... | no |
56bb6b0eac7ad1001900000e | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | Mechanism of action of flibanserin, a multifunctional serotonin agonist and antagonist (MSAA), in hypoactive sexual desire disorder. Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire. ... | yes |
53267871d6d3ac6a3400000a | Is recommended the use of perioperative treatment with thyroid hormone therapy in patients undergoing coronary artery bypass grafting? | Short duration postoperative iv T(3) therapy increases cardiac index and does not alter mortality. We conclude that although widespread interest has been shown on the use of thyroid hormones in the perioperative period, and the effect of cardiopulmonary bypass on thyroid hormone metabolism widely studied, there is no s... | no |
56e68967edfc094c1f000002 | Is protein CXCR4 used as a prognostic marker of cancer? | Aberrant overexpression of CXCR4 is associated with worse overall survival, adenocarcinoma histology, distant metastasis, lymph node involvement in NSCLC. CXCR4 belongs to a family of G protein-coupled cell surface receptors and has been proved to a prognostic marker in a various tumors, including esophageal squamous c... | yes |
5321b4959b2d7acc7e000007 | Is transcapillary albumin escape altered in diabetic patients? | On the contrary, altered TERalb and increased carotid artery intimal thickness are shown by all hypertensive type 2 diabetic patients, both with normal and altered patterns of AER. Altered systemic capillary permeability characterizes insulin-resistant hypertensive patients with Metabolic Syndrome. TERalb is increased ... | yes |
553d02c1f321868558000012 | Are conserved noncoding elements associated with developmental genes? | Some characteristics of CNEs include their high frequency in mammalian genomes, their potential regulatory role in gene expression, and their enrichment in gene deserts nearby master developmental genes we review recent findings that disruptions of CNEs, within or at long distance from the coding sequences of key genes... | yes |
55032d8be9bde69634000033 | Is myasthenia gravis associated with osteoporosis? | We performed PVP in 4 patients with generalized MG associated with recent steroid-induced symptomatic VFs. In this case report, we used tacrolimus to successfully treat a 13-year-old boy with ocular MG who had suffered from severe steroid complications, including a failure of thrive and osteoporosis. INTRODUCTION: My... | yes |
5540a8d20083d1bf0e000001 | Does a selective sweep increase genetic variation? | An East African population that gave rise to non-Africans underwent a selective sweep affecting the subcentromeric region where MTMR8 is located. This and similar sweeps in four other regions of the X chromosome, documented in the literature, effectively reduced genetic diversity of non-African chromosomes a selective ... | no |
53329c84d6d3ac6a34000040 | Is indicated the use of antioxidant supplements in patients at risk for coronary artery disease? | We and others have published observational epidemiologic studies in support of vitamins in the primary prevention of CVD, but the results from intervention studies are mixed. For vitamin E, observational data suggest benefit at doses of 100 to 400 IU/d. Results from recent large-scale trials are mixed, with some showin... | no |
552010076b348bb82c000015 | Is there evidence to suggest that triiodothyronine has neuroprotective properties in traumatic brain injury? | Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury. Treatment with T3 (1.2μg/100g body weight, i.p.) 1h after TBI resulted in a significant improvement in motor and cognitive recovery after CCI, as well as in marked reduction of lesion volumes. Western blot analysis reveal... | yes |
553c011af321868558000009 | Is Lysine-specific demethylase 1 (LSD1) a critical regulator of hematopoiesis? | Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells shRNA-mediated knockdown of LSD1 in hematopoietic precursor cells resulted in altered SALL4 downstream gene expression and increased cellular activity our data r... | yes |
550899c92e93f0133a000003 | Is K-63 linked protein ubiquitination related to proteasomal degradation? | In contrast to K48-linked polyubiquitin chains, K63-linked polyubiquitin chains function in nonproteasomal biological processes. Modification of proteins by the addition of lysine (K)-63-linked polyubiquitin (polyUb) chains is suggested to play important roles in a variety of cellular events, including DNA repair, sign... | no |
56a7d32fa17756b72f000001 | Could transcription factors act as cell-cell signalling molecules? | Pax6 is a transcription factor essential for the development of tissues including the eyes, central nervous system and endocrine glands of vertebrates and invertebrates. It regulates the expression of a broad range of molecules, including transcription factors, cell adhesion and short-range cell-cell signalling molecul... | yes |
52d7b45e98d0239505000002 | is pharmacological treatment of subclinical hypothyroidism effective in reducing cardiovascular events? | The decision to treat elderly people is still an unresolved clinical challenge--first, due to a lack of appropriately powered randomized controlled trials of L-T4 in sHT patients, examining cardiovascular hard endpoints in various classes of age; and second, because of the negative effects of possible overtreatment. Th... | no |
52e8e96698d023950500001f | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | Two siblings died suddenly at the ages of 9 and 10 years Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a type of cardiac arrhythmia that occurs in people with a structurally normal heart. Stress or anxiety-induced release of endogenous catecholamines causes a dysfunction in the myocytic calcium-ion ch... | yes |
517404878ed59a060a000023 | Are histone deacetylase (HDAC) inhibitors good candidates to control metastasis of solid tumors? | JNJ-26481585 also fully inhibited the growth of C170HM2 colorectal liver metastases, whereas again 5-fluorouracil/Leucovorin showed modest activity. Although not meeting the RECIST response criteria for adequate single-agent activity, the observed tolerable toxicities and the potential for clinical benefit in terms of ... | yes |
54f704b630767eb92e000001 | Is muscle lim protein (MLP) involved in cardiomyopathies? | Muscle LIM protein (MLP) has been proposed to be a central player in the pathogenesis of heart muscle disease. In line with this notion, the homozygous loss of MLP results in cardiac hypertrophy and dilated cardiomyopathy. Moreover, MLP is induced in several models of cardiac hypertrophy such as aortic banding and myoc... | yes |
571f33f10fd6f91b68000004 | Have 5q35 microdeletions been implicated in Sotos syndrome development? | Loss-of-function mutations of NSD1 and 5q35 microdeletions encompassing NSD1 are a major cause of Sotos syndrome (Sos), which is characterized by overgrowth, macrocephaly, characteristic facies, and variable intellectual disability (ID) We observed a novel 3.5 Mb 5q subtelomeric deletion in a 3-year-old girl with devel... | yes |
5328185dd6d3ac6a3400000e | Is metabolic syndrome related with cardiovascular disease? | The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an increased risk for cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). As a molecular link between metabolic signals, in... | yes |
52f77f752059c6d71c00002b | Are defects in recombination repair involved in carcinogenesis? | Inherited mutations in genes involved in HR are associated with gene rearrangement and may be a prerequisite for tumor development in some cancer-prone hereditary diseases like Bloom, Werner and Rothmund-Thomson syndromes. Variants in the XRCC3 gene might result in altered protein structure or function which may influ... | yes |
5721f6f90fd6f91b68000012 | Are seizures among the neurological symptoms of incontinentia pigmenti? | High-dose glucocorticoid therapy in the management of seizures in neonatal incontinentia pigmenti Incontinentia pigmenti is an X-linked dominant disorder resulting from a mutation of IKBKG. This disorder has a classic dermatologic presentation, but neurologic involvement, with seizures and cortical infarction, can aris... | yes |
56c332a350c68dd41600000d | Is there a genome-wide technique for the detection of R-loop formation? | Genome-wide analysis of fragile sites by chromatin immunoprecipitation (ChIP) and microarray (ChIP-chip) of phosphorylated H2A in these mutants supported a transcription-dependent mechanism of DNA damage characteristic of R loops We have used a bisulfite-sensitivity assay to demonstrate genome-wide increase in the occu... | yes |
571394141174fb175500000b | Can bioprinting use human cells? | In this study, human adipose-derived stem cells (hASCs) were printed in a free-scalable 3D grid pattern by means of LaBP. Additionally, we provide the proof that even pre-differentiated hASCs could be utilized for the generation of 3D tissue grafts. To explore the three dimensional(3D)bioprinting technology, using hu... | yes |
5544f3005beec11c10000008 | Is transcription-associated mutagenesis (TAM) related to gene expression levels? | These mutations were frequent in plasmid-borne lacS expressed at a high level but not in single-copy lacS in the chromosome or at lower levels of expression in a plasmid. The results suggest that important DNA repair or replication fidelity functions are impaired or overwhelmed in pJlacS, with results analogous to thos... | yes |
514a1469d24251bc05000056 | Is there a pharmacogenetic test for trastuzumab? | The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing. the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therapy... | yes |
54d630283706e89528000004 | Do carmustine wafers improve survival of glioblastoma patients? | At recurrence, treatment options include repeat surgery (with or without Gliadel wafer placement), reirradiation or systemic therapy. DISCUSSION: Carmustine wafers for primary HGG surgery in accordance with the NICE TA121 were associated with a median survival of 15.3 months; this is improved compared with previously ... | yes |
5516fc8832767d0305000002 | Is Dicer part of the RISC loading complex? | Dicer is a component of the protein machinery (the RNA Induced Silencing Complex [RISC]) which is involved in catalyzing the formation of mature microRNAs from their precursors in the process of microRNA biogenesis. RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor cor... | yes |
54ecb66d445c3b5a5f000002 | Is hypersensitivity to DNA crosslinking agents a hallmark of Fanconi anemia? | The Fanconi anemia (FA) core complex plays a central role in the DNA damage response network FAAP100-deficient cells display hallmark features of FA cells, including defective FANCD2 monoubiquitination, hypersensitivity to DNA crosslinking agents, and genomic instability. Fanconi anemia (FA) is a rare genetic disorder ... | yes |
5713c7dd1174fb1755000014 | Have C12orf65 mutations been associated with axonal neuropathy and optic atrophy? | Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy Charcot-Marie Tooth disease (CMT) forms a clinically and genetically heterogeneous group of disorders. Although a number of disease genes have been identified for CMT, the gene discovery for some complex form of CMT has lagged behind. The ass... | yes |
550bf315c2af5d5b7000000e | Is cystatin C or cystatin 3 used as a biomarker of kidney function? | to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes. Cystatin C, a more specific kidney function biomarker, was also elevated at 24 h after CLP. This study evaluated FGF-23 as well as tradition... | yes |
57136cbf1174fb1755000007 | Can fetal aneuploidy be detected with non-invasive prenatal testing? | Non-invasive prenatal testing with cell-free DNA: US physician attitudes toward implementation in clinical practice. The aim of this study was to assess awareness, potential adoption, and current utilization of non-invasive prenatal testing (NIPT) analysis for common fetal aneuploidies among obstetricians Cell-free DNA... | yes |
56c1d841ef6e39474100002d | Is dichlorphenamide effective for periodic paralysis? | BACKGROUND AND PURPOSE: Acetazolamide and dichlorphenamide are carbonic anhydrase (CA) inhibitors effective in the clinical condition of hypokalemic periodic paralysis (hypoPP). In one study dichlorphenamide (DCP) vs placebo was tested in two groups of participants: 42 with hypokalemic periodic paralysis (HypoPP) and 3... | yes |
56bb68a5ac7ad1001900000a | Is nivolumab used for treatment of Non–Small-Cell Lung Cancer? | BACKGROUND: Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a fully human IgG4 programmed... | yes |
516c0e08298dcd4e5100006d | Does thyroid hormone receptor beta1 affect insulin secretion? | We demonstrated that thyroid hormone T3 rapidly induces Akt activation in pancreatic beta cells rRINm5F and hCM via thyroid hormone receptor (TR) beta1. The silencing of TRbeta1 expression through RNAi confirmed this receptor to be crucial for the T3-induced activation of Akt. T3 is able to specifically activate Akt in... | no |
5710dd61cf1c32585100002e | Does replication timing affect the rate of somatic mutations? | Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome ll classes of substitutions are affected, suggesting a generalized mechanism involving replication time-dependent DNA damage We show t... | yes |
57091eefcf1c325851000016 | Is NOD1 activated in inflammation? | Nod1 and Nod2 control bacterial infections and inflammation The Nod proteins Nod1 and Nod2 are two NLR family members that trigger immune defense in response to bacterial peptidoglycan Nod proteins fight off bacterial infections by stimulating proinflammatory signaling and cytokine networks and by inducing antimicrobia... | yes |
54d62ede3706e89528000002 | Does magnesium sulfate improve outcomes of subarachnoid hemorrhage patients? | CONCLUSION: Patients assigned a higher serum magnesium concentration had a reduced incidence of vasospasm as seen by angiography, but the difference was not statistically significant. Clinically significant outcomes were not different between groups. 158 patients (26·2%) had poor outcome in the magnesium group compared... | no |
532c169ed6d3ac6a3400001f | Are there plasma membrane receptors for thyroid hormones? | ntegrins are heterodimeric structural components of the plasma membrane whose ligands include a large number of extracellular matrix (ECM) proteins. Recently, integrin αvβ3 has been shown to have a panel of previously unappreciated small molecule receptor sites for thyroid hormone and hormone analogues, for dihydrotes... | yes |
56b9c937ac7ad10019000001 | Does Rad9 interact with Aft1 in S.cerevisiae? | Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae. Here we show that Rad9 checkpoint protein, known to mediate the damage signal from upstream to downstream essential kinases, interacts with Aft1 transcription factor in the budd... | yes |
5162e011298dcd4e51000049 | Are there any desmins present in plants? | Inherited mutations in the gene coding for the intermediate filament protein desmin have been demonstrated to cause severe skeletal and cardiac myopathies. Mutations in the intermediate filament (IF) protein desmin cause severe forms of myofibrillar myopathy characterized by partial aggregation of the extrasarcomeric d... | no |
513711055274a5fb0700000e | Are viruses involved in the etiology of human subacute thyroiditis? | he etiology of subacute (de Quervain's) thyroiditis (SAT) is uncertain, although it probably represents a nonspecific inflammatory response by the thyroid to a variety of viruses. Subacute thyroiditis is an inflammatory disorder of the thyroid caused probably by viruses. I We believe that the etiologic agent was the Ep... | yes |
51485008d24251bc05000028 | Is miR-126 involved in heart failure? | he miRNAs miR-126 and miR-508-5p are associated with the outcome of ICM and NICM patients with CHF. These two miRNAs could be useful in the diagnosis of CHF patients, and might provide novel targets for prevention and treatment of CHF. The plasma concentration of miR-126 was negatively correlated with age and NYHA clas... | yes |
52e7bbf698d023950500001d | Does resveratrol reduce cardiac remodeling? | In conclusion, resveratrol attenuated cardiac oxidative damage and left ventricular remodeling and enhanced the decreased expression of SIRT1 in hearts of old rats with emphysema and thus might be a therapeutic modality for cardiac injury complicated in chronic obstructive pulmonary disease (COPD). In conclusion, resve... | yes |
5545dc7de233d84047000001 | Is there a role for transcription factories in genome organization? | The mammalian nucleus is a highly complex structure that carries out a diverse range of functions such as DNA replication, cell division, RNA processing, and nuclear export/import. Many of these activities occur at discrete subcompartments that intersect with specific regions of the genome. Over the past few decades, e... | yes |
515ed87c298dcd4e51000032 | Do selenoproteins and selenium play a role in prostate cancer prevention? | The selenoprotein-deficient mice exhibited accelerated development of lesions associated with prostate cancer progression, implicating selenoproteins in cancer risk and development and raising the possibility that selenium prevents cancer by modulating the levels of these selenoproteins Notably and in contrast to previ... | no |
54d796f93706e8952800001e | Has protein citrullination been implicated in rheumatoid arthritis? | : Citrullination has become a hot topic within recent years due to its involvement in diseases such as rheumatoid arthritis (RA), multiple sclerosis and fibrosis. Current literature suggests that increased levels of citrullinated proteins are found in several if not all inflammatory diseases. Antibodies directed agai... | yes |
56e2985951531f7e33000013 | Do R-loops tend to form at sites of DNA replication? | Escherichia coli rnhA mutants devoid of RNase HI exhibit constitutive stable DNA replication, cSDR, which is thought to be initiated from R-loops stabilized in the absence of RNase HI. We propose that the organized structure of the R-loop is critical for primer RNA function in vivo with important implications for the R... | yes |
550c1ca3a103b78016000003 | Is selenium deficiency involved in autoimmune thyroid disease? | In areas with severe selenium deficiency higher incidence of thyroiditis has been reported due to a decreased activity of selenium-dependent glutathione peroxidase enzyme within thyroid cells Of 30 patients in the selenium treated group, 6 patients were overtly hypothyroid, 15 were subclinical hypothyroid, 6 were euthy... | yes |
52bf1aa503868f1b06000006 | Is it safe to use Abatacept during pregnancy? | These patients were exposed to rituximab (anti-CD20 monoclonal antibody) or abatacept (fusion protein CTLA4Ig) during the first trimester of their pregnancies. No significant adverse effects or complications were observed during the pregnancies, and all three patients delivered healthy newborns. Despite these favorabl... | no |
56cdf3995795f9a73e00003a | Is STAT3 involved in EIF2AK2-dependent suppression of autophagy? | STAT3 may act as a competitive inhibitor of EIF2AK2. Indeed, pharmacological or genetic inhibition of STAT3 stimulates EIF2AK2-dependent EIF2S1 phosphorylation and autophagy. Conversely, the overexpression of wild-type STAT3 as well as of STAT3 mutants that cannot be phosphorylated by JAK2 or are excluded from the nucl... | yes |
56a375f8496b62f23f000002 | Are CTCF and BORIS involved in genome regulation and cancer? | CTCF is ubiquitously expressed and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal interactions, nuclear compartmentalisation, and alternative splicing. CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in cancer. The ... | yes |
5709e947cf1c32585100001d | Are Sidekick proteins members of the immunoglobulin superfamily? | Here we show that four closely related immunoglobulin superfamily (IgSF) adhesion molecules--Dscam (Down's syndrome cell adhesion molecule), DscamL (refs 6-9), Sidekick-1 and Sidekick-2 Sidekick-1, a cell adhesion molecule of the immunoglobulin superfamily, is up-regulated in glomerular podocytes in the collapsing glom... | yes |
53552ed7f1005d6b58000001 | Have mutations in the ZEB2 gene been found in any human syndrome? | Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene Mowat-Wilson syndrome (MWS; OMIM#235730) have characteristic facial features, a variety of congenital anomalies such as Hirschsprung disease, and intellectual disabilities cau... | yes |
54f42f2764850a5854000005 | Are the Fanconi anemia genes a part of the same signalling pathway? | Mutations in at least 14 different genes have been shown to cause FA The FA genes code for proteins that act in complexes to coordinate the repair of damaged DNA The current review describes the structure and function of the Fanconi anemia genes and describes the role of the encoded Fanconi anemia proteins in a cellul... | yes |
56f160a52ac5ed1459000013 | Are there clinical trials using stem cells for the treatment of cardiac disease? | Therapy with mesenchymal stem cells is one of the promising tools to improve outcomes after myocardial infarction. Adipose-derived stem cells (ASCs) are an ideal source of mesenchymal stem cells due to their abundance and ease of preparation. Furthermore, several ongoing clinical trials using ASCs are producing promisi... | yes |
54d9f7894b1fd0d33c00000a | Is DNA methylation an epigenetic modification of chromatin related to gene expression? | DNA methylation is a chemical modification of DNA involved in the regulation of gene expression by controlling the access to the DNA sequence. Epigenetic marks such as DNA methylation play important biological roles in gene expression regulation and cellular differentiation during development. DNA methylation patterns... | yes |
553bd2f0f321868558000008 | Is Growth factor independence 1b (GFI1B) important for hematopoiesis? | Growth Factor Independence (Gfi) transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic stem/progenitor cell (HSPC) development and lineage specification gfi1aa and gfi1b have distinct roles in regulating primitive and de... | yes |
56ed0ba22ac5ed1459000007 | Has Revlimid been approved by the US Food and Drug Administration? | In the past decade, immunomodulatory drugs have been approved by the US Food and Drug Administration for the treatment of multiple myeloma (MM)-and a number of emerging agents that target the cellular pathways or proteins involved in the pathophysiology of MM are currently in development. Lenalidomide (Revlimid) and po... | yes |
56f1547c2ac5ed1459000010 | Has single guide RNA been used on human cells? | We used a library containing 73,000 sgRNAs to generate knockout collections and performed screens in two human cell lines. Here we engineer this system to enable RNA-guided genome regulation in human cells by tethering transcriptional activation domains either directly to a nuclease-null Cas9 protein or to an aptamer-m... | yes |
570a5c27cf1c325851000023 | Is Fibroblast Growth Factor 23 a phosphaturic hormone? | PTH can induce skeletal synthesis of another potent phosphaturic hormone, fibroblast growth factor 23 (FGF23), Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that has recently been identified as a CKD-related factor affecting CRS. circulating phosphaturic hormone fibroblast growth factor-23 levels F... | yes |
56bb69d0ac7ad1001900000c | Is amoxicillin used for treatment of malnutrition in children? | Another RCT did not show superiority of ceftriaxone over amoxicilllin for these same outcomes, but adressed SAM children with and without complications (p = 0.27). Another RCT showed no difference between amoxicillin and cotrimoxazole efficacies for pneumonia in underweight, but not SAM. Our meta-analysis of 12 pooled ... | yes |
52e01f8f98d023950500000f | Is it possible to purify pseudopodia to be used for proteomic analysis? | we developed an approach to biochemically isolate the pseudopodium from the cell body using 3.0-micrometer porous filters for large-scale quantitative proteomic and phosphoproteomic analysis. Recent work using unique subcellular fractionation methodologies combined with spatial genomic, proteomic, and phosphoproteomic ... | yes |
55263a1898daae017c000001 | Is farnesoid X receptor (FXR) a nuclear receptor? | Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism Farnesoid X receptor (FXR) is an ascending target for metabolic and infla... | yes |
5319a752b166e2b806000027 | Are DNA helicases involved in progeroid syndromes? | Among these syndromes, relevant advances have recently been made in Werner syndrome, one of several progeroid syndromes characterized by defective DNA helicases, Progeroid syndromes (PSs) constitute a group of disorders characterized by clinical features mimicking physiological aging at an early age. However, all the c... | yes |
56c1d85eef6e394741000035 | Is there association of matrix metalloproteinases with behaviour of pituitary adenomas? | While detailed histological subtyping remains the best independent predictor of aggressive behavior in the majority of cases, evidence suggests that the additional analyses of FGFR4, MMP, PTTG, Ki-67, p53, and deletions in chromosome 11 may contribute to decisions concerning management of aggressive pituitary adenomas.... | yes |
515def40298dcd4e51000028 | Is Vitamin D deficiency in pregnant women associated with gestational diabetes? | Insufficient serum levels of 25-OHD were associated with gestational diabetes (pooled odds ratio 1.49, 95% confidence interval 1.18 to 1.89 Vitamin D insufficiency is associated with an increased risk of gestational diabetes, p Therefore, it is important to identify potentially modifiable risk factors for GDM. Accumula... | yes |
52ef6da1c8da898910000011 | Does Chromatin Immunoprecipitation (ChIP) show a bias for highly expressed loci? | However, several issues in the processing and analysis of ChIP-chip data have not been resolved fully, including the effect of background (mock control) subtraction and normalization within and across arrays Proper normalization is essential for ChIP-chip experiments. The proposed normalization technique can correct s... | yes |
5319ac18b166e2b806000030 | Is clathrin involved in E-cadherin endocytosis? | We demonstrated that GnT-III induced a stabilizing effect on E-cadherin at the cell membrane by inducing a delay in the turnover rate of the protein, contributing for the formation of stable and functional adherens-junctions, and further preventing clathrin-dependent E-cadherin endocytosis. Conversely, GnT-V promotes t... | yes |
533c3871c45e133714000007 | Does splicing occur co-transcriptionally? | Researchers working in multiple model organisms - notably yeast, insects and mammalian cells - have shown that pre-mRNA can be spliced during the process of transcription (i.e. co-transcriptionally), as well as after transcription termination (i.e. post-transcriptionally) The consensus view, based on four organisms, is... | yes |
515df5b2298dcd4e5100002c | Are there clinical trials on stem cells in multiple sclerosis | Cells are generally given intravenously. Multiple sclerosis, rheumatoid arthritis and lupus have been successfully treated in human clinical trials Human multipotent mesenchymal stem cell (MSC) therapies are currently being tested in clinical trials for Crohn's disease, multiple sclerosis, graft-versus-host disease, ty... | yes |
56c6f6005795f9a73e000009 | Are piRNAs involved in gene silencing? | In Drosophila ovaries, the nuclear Piwi protein is required for transcriptional silencing of transposons, though the precise mechanisms by which this occurs are unknown. Here we show that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcrip... | yes |
56ed08062ac5ed1459000005 | Can RG7112 inhibit MDM2? | To assess the influence of the p53 regulatory pathway further, we studied the effect of RG7112, a small molecule MDM2 antagonist that activates p53 by preventing its interaction with MDM2, on normal megakaryocytopoiesis and platelet production. RG7112 (2g) is the first clinical small-molecule MDM2 inhibitor designed to... | yes |
532f08dcd6d3ac6a3400002a | Are there any specific antidotes for dabigatran? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs. ... | no |
54fefbbc6ad7dcbc1200000a | Are there any Decision support systems for chronic pain management ? | a project to operationalize the 2003 VA/DOD Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain into a computerized decision support system (DSS) We based the DSS on the existing ATHENA-DSS Use of this iterative process led to development of a multifunctional DSS interactive decision dashboard fo... | yes |
516d5baa298dcd4e51000078 | Does amiodarone affect thyroid hormone receptors in the myocardium? | AM and Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50% In the LVW, AM and Dron decreased TRbeta 1 and, interestingly, AM increased TRalpha 1. n the apex, AM also increased TRalpha 2. Both in treated and untreated mice, TRalpha2 mRNA had the highest density in m... | yes |
52efc041c8da89891000001b | Does thyroid hormone affect cardiac remodeling? | The aim of this brief paper is to highlight new developments in understanding the cardioprotective role of thyroid hormone in reverting regulatory networks involved in adverse cardiac remodeling. Thyroid hormone receptor α1 (TRα1) is shown to be critical for the maturation of cardiomyocytes and for the cellular respons... | yes |
53353927d6d3ac6a34000043 | Are there any HCV replication inhibitors available? | We report here the discovery of the first small-molecule HCV infectivity inhibitor, GS-563253, also called HCV infectivity inhibitor 1 (HCV II-1). Resistance to mericitabine (prodrug of HCV NS5B polymerase inhibitor PSI-6130) is rare and conferred by the NS5B S282T mutation. We tested the ability of NA808 to inhibit S... | yes |
511a4ec01159fa8212000004 | Is miR-21 related to carcinogenesis? | miR-21* and miR-203 were significantly dysregulated (P < 0.05) in PTC tissues with BRAFV600E. Expressions of miRNAs in papillary thyroid carcinoma and their associations with the BRAFV600E mutation. Levels of miRNA-21 (miR-21) and miR-106a in gastric cancer tissues were significantly higher compared with the levels in ... | yes |
52ecd56198d023950500002b | Are thyroid hormone receptor alpha1 mutations implicated in thyroid hormone resistance syndrome? | Mutations in human TRα1 mediate RTH with features of hypothyroidism in particular tissues (e.g. skeleton, gastrointestinal tract), but are not associated with a markedly dysregulated pituitary-thyroid axis. Clinical phenotype of a new type of thyroid hormone resistance caused by a mutation of the TRα1 receptor | yes |
551910fa622b19434500000b | Is PLK2 involved in alpha-synuclein phosphorylation in Parkinson disease? | An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease Here, we report that Polo-like kinase 2 (PLK2), an enzyme up-regulated in synucleinopathy-diseased brains, interacts with, phosphorylates and en... | yes |
53177803b166e2b80600000e | Is there evidence for somatic mosaicism in Tuberous Sclerosis? | There are several case reports of solitary SEGA without any other manifestations of TSC. Usually these cases are thought to be forme fruste of TSC due to somatic mosaicism. Female germline mosaicism in tuberous sclerosis confirmed by molecular genetic analysis This is the first case of germline mosaicism in tuberous sc... | yes |
550e7d6aa103b7801600000e | Does smoking increase risk for glioblastoma? | Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of ... | no |
56e6f027a12c1fc13b000001 | Is Wnt16b secreted in response to chemotherapy? | In this study, we found WNT16B could be expressed and secreted into the microenvironment by human ovarian fibroblasts after DNA damage-associated treatment, including chemotherapy drugs and radiation. In a recent article in Nature Medicine, Sun et al. show that increased expression of Wnt family member wingless-type MM... | yes |
5162f5b6298dcd4e5100004c | Do DNA double-strand breaks play a causal role in carcinogenesis? | The DNA non-homologous end-joining repair gene XRCC6/Ku70 plays an important role in the repair of DNA double-strand breaks (DSBs) induced by both exogenous and endogenous DNA-damaging agents. Defects in overall DSB repair capacity can lead to genomic instability and carcinogenesis. The tumor suppressor breast cancer s... | yes |
5544df2a5beec11c10000006 | Do conserved noncoding elements co-occur with matrix-attachment regions? | We hypothesized that some of these regions might be matrix-scaffold attachment regions, MARs (or S/MARs). MARs comprise one of the few classes of eukaryotic noncoding DNA with an experimentally characterized function, being involved in the attachment of chromatin to the nuclear matrix, chromatin remodeling and transcri... | yes |
56d1accb67f0cb3d66000001 | Are Drosophila ultraconserved elements candidate ncRNAs? | Highly constrained intergenic Drosophila ultraconserved elements are candidate ncRNAs. Here, we report the discovery and characterization of UCEs from 12 sequenced Drosophila species. We identified 98 elements ≥80 bp long with very high conservation across the Drosophila phylogeny. Population genetic analyses reveal th... | yes |
54f088ee94afd61504000015 | Does surgery for ovarian endometriomas improve fertility? | CONCLUSION: Endometriomas per se appear to be the main cause of the reduced long-term reproductive performance of the affected patients, with little or no contribution from surgery. Furthermore, endometrioma surgery seems to improve the success rates of fertility treatment. Amongst the 38 women desiring pregnancy after... | yes |
552440452c8b63434a00000b | Are ACTA1 (alpha actin) and NEB (nebulin) genes related to nemaline myopathy? | Nemaline myopathy (NM) is a group of congenital myopathies, characterized by the presence of distinct rod-like inclusions "nemaline bodies" in the sarcoplasm of skeletal muscle fibers. To date, ACTA1, NEB, TPM3, TPM2, TNNT1, and CFL2 have been found to cause NM. Nemaline myopathy (NM) is the most common congenital myop... | yes |
56ed0a372ac5ed1459000006 | Could RG7112 be used as cancer therapy? | RG7112 is a potent and selective member of the nutlin family of MDM2 antagonists currently in phase I clinical studies. Our findings offer a preclinical proof-of-concept that RG7112 is effective in treatment of solid tumors expressing wild-type p53. On the other hand, JNJ-26854165, a novel tryptamine derivative and RG7... | yes |
52e7b4a198d023950500001b | Does thyroid hormone affect cardiac remodeling ? | Thyroid hormones exert important effects on heart remodeling through mir-208. RV and RA function and mechanics are significantly affected by SHT. l-T4 therapy and 1-year maintenance of euthyroid status improved but did not completely recover RV and RA function and deformation in the SHT patients, which implies that rig... | yes |
54f1e781c409818c32000003 | Is armodafinil used for treatment of insomnia? | Other therapies, such as sedative hypnotics, target daytime insomnia, while pharmacologic agents such as modafinil, armodafinil, and caffeine and non-pharmacologic approaches such as napping promote nighttime alertness. Other treatment options may include pharmacologic interventions such as modafinil and armodafinil, w... | no |
56b481348525abca1e000008 | Are there currently applications of deep learning in genomics? | Deep learning of the tissue-regulated splicing code. Using a deep neural network, we developed a model inferred from mouse RNA-Seq data that can predict splicing patterns in individual tissues and differences in splicing patterns across tissues. Our architecture uses hidden variables that jointly represent features in ... | yes |
5133b15e5274a5fb0700000b | Are CpG islands located close to housekeeping genes? | our analysis indicates that the association of CGIs with housekeeping genes is not as strong as previously estimated CpG islands are preferentially located at the start of transcription of housekeeping genes and are associated with tissue-specific genes It has been envisaged that CpG islands are often observed near the... | yes |
5162a089298dcd4e51000043 | Have microRNAs been implicated in pharmacogenomics? | A major discovery is the ability of miRNAs to determine the efficacy of drugs, which has given rise to the field of 'miRNA pharmacogenomics' through 'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. The potential modulation of toxicology-r... | yes |
56c03d1fef6e39474100001a | Is nicotinamide effective for skin cancer prevention? | Nicotinamide (vitamin B3) has been shown to have protective effects against damage caused by UV radiation and to reduce the rate of new premalignant actinic keratoses. ESULTS: At 12 months, the rate of new nonmelanoma skin cancers was lower by 23% (95% confidence interval [CI], 4 to 38) in the nicotinamide group than i... | yes |
54d8d4d1014675820d000006 | Do Parkinson's disease patients experience stridor? | The authors describe a patient experiencing stridor and dysphagia with confirmed pulmonary restriction and aspiration following subthalamic nucleus deep brain stimulator adjustment, with a resolution of symptoms and signs when the stimulator was switched off. Stridor was not noted during sleep at night. Endoscopic exam... | yes |
54cf4bc3f693c3b16b00000d | Is there an association between serum interleukin-6 concentrations and outcomes of stroke patients? | In addition, IL-6 concentrations affect clinical outcomes in ischemic stroke. After appropriate adjustment, the odds ratios for the association of markers and poor outcome (comparing the upper and the lower third) were interleukin-6, 3.1 (95% CI: 1.9-5.0); C-reactive protein, 1.9 (95% CI: 1.2-3.1); fibrinogen, 1.5 (95%... | yes |
5713968e1174fb175500000d | Could bioprinting be used in regenerative medicine against bone disease? | Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. It is expected... | yes |
51bedaac3148fdcc22da7188 | Is macroautophagy a selective degradation process? | Selective autophagy Macroautophagy (autophagy) is a bulk degradation system for cytoplasmic components and is ubiquitously found in eukaryotic cells Here we show that selective autophagy downregulates Ty1 transposition We propose that selective autophagy safeguards genome integrity against excessive insertional mutagen... | yes |
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