Datasets:

ClarusC64
/

pharma-adaptation-early-phase-detection-v0.1

id string	trial_context string	compound string	dose_regimen string	baseline_state_summary string	early_signal_window string	biomarker_shift_summary string	cross_system_coupling_notes string	observed_short_term_effect string	adaptation_onset_time string	acute_response_pattern string	coupling_shift_signature string	stabilization_direction string	early_compensation_flag int64	trajectory_seed_class string	confidence_score float64	notes string	constraints string	gold_checklist string
EAPD-001	phase1 healthy	compound-A	single low dose	stable metabolic baseline	0-24h	glucose down; insulin up mild	liver-muscle coupling intact	mild metabolic shift	t=6h	smooth_adjustment	tightened metabolic coupling	toward_new_stable	0	durable_seed	0.78	clean adaptation	Under 220 words	onset+pattern+coupling+direction+flag+class+confidence
EAPD-002	phase1 patient	compound-B	daily x3	inflamed baseline	0-48h	cytokine drop then rebound	immune-liver coupling oscillates	initial symptom relief	t=10h	oscillatory	immune rebound loop	unstable	1	compensatory_seed	0.71	early rebound	Under 220 words	onset+pattern+coupling+direction+flag+class+confidence
EAPD-003	phase1 healthy	compound-C	single high	normal baseline	0-12h	HR up; cortisol spike	cardio-endocrine decouple	agitation	t=2h	stress_response	decoupled cardio-endocrine	destabilizing	1	destabilizing_seed	0.82	rapid stress	Under 220 words	onset+pattern+coupling+direction+flag+class+confidence
EAPD-004	phase1 patient	compound-D	daily low	fatigue baseline	0-72h	ATP markers rise steady	mito-neuro coupling improves	energy gain	t=18h	gradual_alignment	mitochondrial coherence rise	toward_new_stable	0	durable_seed	0.75	positive adaptation	Under 220 words	onset+pattern+coupling+direction+flag+class+confidence
EAPD-005	phase1 healthy	compound-E	single dose	normal baseline	0-24h	dopamine spike then normalize	neuro-endocrine stable	mild alertness	t=4h	transient_adjustment	short coupling fluctuation	returns_baseline	0	neutral_seed	0.69	neutral	Under 220 words	onset+pattern+coupling+direction+flag+class+confidence
EAPD-006	phase1 patient	compound-F	daily	autoimmune baseline	0-48h	inflammation down then drift	immune-metabolic drift	partial relief	t=12h	partial_adjustment	metabolic strain rising	fragile	1	oscillatory_seed	0.73	fragile stabilization	Under 220 words	onset+pattern+coupling+direction+flag+class+confidence

What this dataset tests

Whether a system can detect the earliest systemic adaptation to a drug.
It evaluates how the human system begins to stabilize, compensate, or destabilize.

Required outputs

adaptation_onset_time
acute_response_pattern
coupling_shift_signature
stabilization_direction
early_compensation_flag
trajectory_seed_class
confidence_score

Use case

Early-phase trial interpretation.
Predict long-term tolerance or durability from short-term data.
Identify drugs that induce coherent stabilization vs compensation.

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