Datasets:

ClarusC64
/

clinical-tpib-pathway-stability-and-risk-guardrails-v0.1

id stringclasses 10 values	patient_profile stringclasses 10 values	manifold_label stringclasses 7 values	risk_flags stringclasses 10 values	proposed_top3 stringclasses 10 values	known_failure_signatures stringclasses 8 values	stability_label stringclasses 4 values	guardrail_actions stringclasses 10 values	guardrail_rationale stringclasses 10 values	failure_signature stringclasses 7 values	constraints stringclasses 1 value	gold_checklist stringclasses 8 values
TPIB-SRG-001	62M, opioid tolerance loop	acute_then_tolerance	resp_dep_risk=1; prior_tolerance=1	1) opioid increase 2) physio 3) CBT pain	tolerance_loop_repeat	contraindicated_move	Block opioid escalation; taper plan; naloxone; close follow-up	Manifold shows tolerance with worsening. Escalation breaks stability	tolerance-loop-repeat	Under 220 words.	1 contraindicated; 2 guardrail includes taper
TPIB-SRG-002	46M, SSRI paradoxical worsening	paradoxical_worsening	sleep_loss=1	1) SSRI retrial 2) CBT 3) beta blocker	paradoxical_retrial	risky_move	Avoid SSRI retrial; trial non-SSRI options; monitor sleep weekly	Prior harm predicts repeat harm	paradoxical-retrial	Under 220 words.	1 risky; 2 avoid retrial
TPIB-SRG-003	39F, inflammatory pain	acute_then_tolerance	steroid_side_effects=1	1) DMARD 2) short steroid bridge 3) sleep protocol	steroid_tolerance_risk	stable_move	Limit steroid bridge to 2-4 weeks; taper plan; CRP checks	Bridge can help but needs limits to avoid tolerance	none	Under 220 words.	1 stable with guardrail
TPIB-SRG-004	41F, autoimmune GI on-off coupling	oscillatory_response	infection_risk=1	1) optimize biologic 2) adherence support 3) nutrition	relapse_on_gap	stable_move	Infection monitoring; vaccine review; drug level checks; adherence tracking	Stabilize exposure while managing infection risk	none	Under 220 words.	1 stable
TPIB-SRG-005	29M, insomnia paradoxical	paradoxical_worsening	falls_risk=1	1) sedative retrial 2) CBT-I 3) circadian anchor	paradoxical_retrial	contraindicated_move	No sedative retrial; CBT-I first; sleep diary; screen apnea	Paradoxical prior response. Retrying is unstable	sedative-retrial	Under 220 words.	1 contraindicated
TPIB-SRG-006	55F, metabolic delayed threshold	delayed_threshold_response	GI_side_effect_risk=1	1) GLP1 2) diet structured 3) sleep apnea screen	none	stable_move	Titrate GLP1 slowly; monitor nausea; labs at 8-12 weeks	Threshold move is coherent with manageable risk	none	Under 220 words.	1 stable
TPIB-SRG-007	44M, mixed tradeoff autoimmune + panic	mixed_uncertain	steroid_triggers_panic=1	1) steroid bridge 2) SSRI 3) DMARD	cross_domain_tradeoff	high_variance_move	Avoid steroid bridge; pick DMARD first; psychotherapy; track panic weekly	Tradeoff signatures predict instability	tradeoff-repeat	Under 220 words.	1 high variance
TPIB-SRG-008	50F, flat nonresponse	nonresponse_flat	polypharmacy_risk=1	1) add 3 supplements 2) add stimulant 3) add steroid trial	noise_amplification	risky_move	Stop low-value additions; run 1 change at a time; define endpoints	Flat manifold needs signal extraction not noise	noise-addition	Under 220 words.	1 risky
TPIB-SRG-009	37F, multi-system single target	multi_system_single_target	pregnancy=0	1) continue LDN 2) low risk support 3) targeted workup	none	stable_move	Keep effective lever; avoid stacking high-risk changes; recheck at 6-8 weeks	Stability comes from preserving working lever	none	Under 220 words.	1 stable
TPIB-SRG-010	60F, cardiac risk aligned	multi_system_single_target	cardiac_risk=1	1) no change 2) monitor 3) breathing exercises	undertreatment_risk	risky_move	Escalate cardiology pathway; statin; BP control; do not rely on low-intensity plan	Risk flags require outside-in stabilization	undertreatment	Under 220 words.	1 risky due to undertreatment

What this dataset tests

Given proposed next interventions
classify stability in the response manifold
and add a guardrail that prevents known failure patterns.

Labels

stable_move
high_variance_move
risky_move
contraindicated_move

Typical failures

repeating tolerance loops
retrial after paradoxical worsening
allowing oscillation through exposure gaps
undertreating high-risk physiology
adding noise in flat nonresponse cases

Suggested prompt wrapper

System

You evaluate pathway stability and propose guardrails.

User

Manifold Label
{manifold_label}

Risk Flags
{risk_flags}

Proposed Top 3
{proposed_top3}

Known Failure Signatures
{known_failure_signatures}

Return

one stability label
2 guardrail actions
one sentence rationale

Citation

ClarusC64 dataset family

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