id stringclasses 6
values | drug_name stringclasses 6
values | condition_context stringclasses 6
values | pre_drug_state_summary stringclasses 6
values | on_drug_state_summary stringclasses 6
values | post_drug_state_summary stringclasses 6
values | observation_window stringclasses 6
values | drift_vector stringclasses 6
values | affected_system_axes stringclasses 6
values | temporal_drift_profile stringclasses 6
values | reversibility_flag stringclasses 3
values | net_coherence_delta stringclasses 4
values | notes stringclasses 6
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SDFE-001 | SSRI | depression | Sleep fragmented; HRV low; appetite variable | Sleep latency improves; HRV flat; GI motility slows | Sleep regresses; GI normalizes | 9 months | Neural calming + GI slowing | neural; gastrointestinal | Gradual onset; slow offset | partial | Neutral | Neural gain with GI cost | Under 220 words. | vector+axes+profile |
SDFE-002 | metformin | type2_diabetes | Glucose high variance; weight rising | Glucose variance down; appetite reduced; GI upset | Glucose stable; GI improves | 12 months | Metabolic stabilization + GI perturbation | metabolic; gastrointestinal | Early GI hit then adaptation | yes | Positive | Classic metabolic drift | Under 220 words. | vector+axes+profile |
SDFE-003 | steroid | autoimmune_flare | Pain high; fatigue; labs variable | Pain down; sleep worse; glucose up | Rebound pain; fatigue persists | 6 months | Inflammation suppression + metabolic stress | immune; metabolic; sleep | Fast onset; rebound offset | no | Negative | Suppression without repair | Under 220 words. | vector+axes+profile |
SDFE-004 | beta_blocker | arrhythmia | HR variability high; anxiety spikes | HR steadier; fatigue up | Fatigue resolves; HR variability returns | 8 months | Autonomic damping | autonomic; cardiovascular | Immediate onset; clean offset | yes | Mixed | Control with energy cost | Under 220 words. | vector+axes+profile |
SDFE-005 | GLP1 | obesity | Weight gain; appetite dysregulated | Weight loss; nausea; low intake | Weight stable; nausea gone | 10 months | Appetite suppression + intake restructuring | metabolic; neural | Stepwise drift then plateau | yes | Positive | Strong appetite axis push | Under 220 words. | vector+axes+profile |
SDFE-006 | benzodiazepine | anxiety | Hyperarousal; insomnia | Anxiety low; sedation high | Rebound anxiety; sleep worse | 7 months | Arousal suppression + dependence drift | neural; sleep | Immediate onset; rebound offset | no | Negative | Fragility fingerprint | Under 220 words. | vector+axes+profile |
What this dataset tests
The whole-system drift pattern
induced by a single drug
over time.
Required outputs
- drift vector
- affected system axes
- temporal profile
- reversibility
- net coherence change
Use case
Foundation layer for the Drug-Induced System Drift Library.
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