Datasets:

ClarusC64
/

clinical-plausible-mechanistic-hypothesis-generation-v0.1

id stringclasses 10 values	case_id stringclasses 10 values	pre_explanation_summary stringclasses 10 values	symptom_trajectory stringclasses 10 values	labs_imaging stringclasses 10 values	narrative_signals stringclasses 10 values	exclusions stringclasses 9 values	proposed_mechanism stringclasses 10 values	explanatory_links stringclasses 10 values	predicted_missing_findings stringclasses 10 values	uncertainty_notes stringclasses 10 values	constraints stringclasses 1 value	gold_checklist stringclasses 1 value
PMHG-001	UE-01	Post-viral fatigue, brain fog, crashes after exertion	delayed post-exertional worsening; orthostatic symptoms	routine labs normal; tilt HR rise	wired-tired; long recovery	autoimmune panels negative	autonomic-metabolic control instability with impaired energy delivery under load	exertion raises demand → autonomic compensation overshoots → perfusion mismatch → delayed crash; arousal loop sustains symptoms	abnormal lactate on exertion test; reduced HRV; symptom reproduction with tilt/exertion challenge	viral persistence vs immune dysregulation unresolved; mechanism may be multi-hit	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-002	UE-02	Migratory pain, GI upset, anxiety; flares with stress	stress-linked flares; variable symptoms	CRP mild; imaging normal	hypervigilance; food fear	structural GI disease excluded	stress-amplified immune signaling with gut-brain axis sensitization	stress ↑ → inflammatory mediators ↑ → gut permeability/sensitivity ↑ → pain and GI symptoms ↑ → anxiety loop reinforces	elevated cytokine markers during flare; symptom reduction with stress modulation; altered microbiome pattern	may overlap with functional disorders; lacks single lesion	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-003	UE-03	Orthostatic dizziness, palpitations, fatigue	postural dependence; improves supine	tilt positive; echo normal	fear of fainting	cardiac disease excluded	baroreflex dysfunction with compensatory sympathetic surges	standing → inadequate vasoconstriction → tachycardia compensation → cerebral hypoperfusion → dizziness → anxiety amplifies surges	low standing norepinephrine response or exaggerated; low BP variability; improved with compression and salt	psych factors may be secondary but amplify; trigger unknown	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-004	UE-04	Chronic pelvic pain with episodic flares; no lesion	cyclic flares; spreading sensitivity	MRI negative	catastrophic framing during flares	infection excluded	central sensitization seeded by intermittent peripheral nociception	peripheral trigger → spinal gain ↑ → pain spread; flare anxiety increases gain and muscle guarding	allodynia on exam; reduced pain thresholds; improvement with graded desensitization	peripheral driver may still exist but undetected	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-005	UE-05	Episodic flushing, rash, GI upset; food triggers; normal baseline tryptase	episodic; trigger-linked	tryptase normal; routine labs normal	detailed trigger tracking	IgE disease excluded	episodic mast-cell mediator release with normal baseline markers	trigger exposure → mediator surge → flushing and GI motility changes; inter-episode labs can normalize	elevated urinary histamine metabolites during attack; response to H1/H2 blockade; reproducible trigger challenge	could be non-mast mediator; testing timing critical	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-006	UE-06	Head pressure and photophobia worsened by exertion; normal MRI	load intolerance pattern	MRI normal	sensory overload descriptions	tumor excluded	neurovascular coupling instability with sensory gating overload	exertion ↑ → autonomic shift → neurovascular mismatch → head pressure; sensory gating failure → photophobia	abnormal pupillary light reflex; provoked symptoms with light/exertion; HRV low during symptoms	migraine spectrum possible but label not the mechanism	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-007	UE-07	Unrefreshing sleep, pain, fatigue; mild sleep study disruption	nonrestorative nights; daytime pain	mild disruption; no apnea	exhaustion language	sleep apnea excluded	sleep-immune coupling failure with nociceptive amplification	fragmented sleep → inflammatory tone ↑ → pain sensitivity ↑ → sleep further fragments	higher CRP/IL-6 after poor nights; improved pain with sleep consolidation intervention	directionality may vary; mood confounds present	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-008	UE-08	Heat intolerance with tachycardia and fatigue	seasonal worsening; heat-triggered flares	thyroid normal	overheating narratives	endocrine disease excluded	thermoregulatory autonomic instability with volume sensitivity	heat exposure → vasodilation ↑ → compensatory tachycardia ↑ → fatigue and dizziness; recovery slow	worse symptoms with dehydration; improved with cooling and volume support; abnormal sweat response testing	could overlap with POTS-like physiology; trigger unknown	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-009	UE-09	Post-infectious fatigue and dizziness with crashes	activity crashes; delayed recovery	routine labs normal	describes relapsing pattern	cardiac disease excluded	post-infectious autonomic control instability with impaired recovery signaling	load → compensation overshoot → delayed symptom rebound; poor re-anchoring after exertion	reduced HRV; abnormal orthostatic vitals; lactate or oxygen extraction changes on exertion test	immune persistence not ruled out	Under 240 words.	mechanism+links+predictions+uncertainty
PMHG-010	UE-10	Pain flares with stress; mild inflammation marker	stress-linked spikes	CRP mild	hypervigilant tone	structural disease excluded	stress-immune amplification loop with central pain gain	stress → cytokine rise → central amplification → pain flare → vigilance increases stress	higher inflammatory markers during flare; improvement with stress intervention; reduced pain thresholds	may represent overlapping syndromes; causal direction uncertain	Under 240 words.	mechanism+links+predictions+uncertainty

What this dataset tests

Whether a model can generate a plausible mechanistic hypothesis
from pre-explanation data under uncertainty.

Required outputs

proposed_mechanism
explanatory_links
predicted_missing_findings
uncertainty_notes

Rules

cover all major symptom clusters
include at least 2 falsifiable predictions
keep physiology plausible
do not anchor on labels

Typical failures

naming a diagnosis label with no mechanism
one symptom explained, others ignored
no testable predictions

Suggested prompt wrapper

System

You generate a plausible mechanistic hypothesis from pre-explanation data.

User

Case
{pre_explanation_summary}

Data
{symptom_trajectory}
{labs_imaging}
{narrative_signals}
{exclusions}

Return

proposed mechanism
explanatory links as a short causal chain
predicted missing findings as tests or markers
uncertainty notes

Citation

ClarusC64 dataset family

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