id stringclasses 6
values | disease_area stringclasses 4
values | patient_profile_summary stringclasses 6
values | omics_signature_summary stringclasses 6
values | digital_biomarker_summary stringclasses 6
values | clinical_history_summary stringclasses 6
values | imaging_summary stringclasses 6
values | baseline_state_summary stringclasses 6
values | patient_manifold_coordinates stringclasses 6
values | basin_assignment stringclasses 6
values | basin_confidence_score float64 0.69 0.82 | basin_boundary_flags stringclasses 2
values | invariant_feature_set stringclasses 6
values | notes stringclasses 6
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PMCB-001 | T2D | mid age; BMI high; sedentary | insulin signaling down; lipogenesis up | low steps; sleep fragmentation | metabolic syndrome; HTN | fatty liver | IR high; CRP mild | x=0.62;y=0.18;z=-0.10 | metabolic_inflammation_basin | 0.78 | near_boundary:no | IR; TG high; CRP mild; fatty liver; low activity | stable basin | Under 280 words | coords+basin+conf+boundary+invariants |
PMCB-002 | T2D | older; BMI moderate; active | mitochondrial genes down; oxidative stress up | steps moderate; HRV low | CKD stage 2; HTN | mild vascular stiffness | IR moderate; fatigue high | x=0.40;y=0.44;z=0.12 | mitochondrial_fatigue_basin | 0.74 | near_boundary:yes | HRV low; fatigue high; oxstress up; mito down | boundary case | Under 280 words | coords+basin+conf+boundary+invariants |
PMCB-003 | RA | female; active flares | TNF axis up; interferon low | sleep poor; activity down | seropositive; morning stiffness | synovitis present | CRP high; pain high | x=-0.22;y=0.71;z=0.35 | TNF_high_inflammatory_basin | 0.82 | near_boundary:no | CRP high; pain high; synovitis; TNF axis up | clean basin | Under 280 words | coords+basin+conf+boundary+invariants |
PMCB-004 | RA | male; pain high; CRP low | interferon axis up; TNF modest | activity down; mood low | seronegative; fibromyalgia overlap | minimal synovitis | pain high; CRP low | x=-0.48;y=0.28;z=0.60 | neuroimmune_pain_basin | 0.69 | near_boundary:yes | pain>>CRP; IFN up; mood low; minimal synovitis | mixed phenotype | Under 280 words | coords+basin+conf+boundary+invariants |
PMCB-005 | HFpEF | older; obese | inflammaging markers up | steps low; HRV low | HTN; AF | diastolic dysfunction | NTproBNP high; edema | x=0.15;y=-0.62;z=0.20 | volume_stress_basin | 0.76 | near_boundary:no | NTproBNP high; HRV low; edema; BP load | classic HFpEF | Under 280 words | coords+basin+conf+boundary+invariants |
PMCB-006 | IBD | young; underweight | IL23 axis up; barrier genes down | sleep disrupted; steps low | frequent flares | bowel wall thickening | CRP moderate; diarrhea | x=-0.70;y=-0.10;z=0.22 | barrier_failure_basin | 0.8 | near_boundary:no | diarrhea; barrier genes down; IL23 up; imaging thickening | clear basin | Under 280 words | coords+basin+conf+boundary+invariants |
What this dataset tests
Whether a system can place patients onto a continuous disease manifold. And identify basins with invariant feature sets.
This is not subtype labeling. It is basin mapping.
Required outputs
- patient_manifold_coordinates
- basin_assignment
- basin_confidence_score
- basin_boundary_flags
- invariant_feature_set
Basin boundary flags
near_boundary yes
Mixed features.
Potential cross-basin transitions.
High risk of response heterogeneity in trials.
Use case
Clinical trial stratification. Mechanism matching. Patient selection by basin.
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