id stringclasses 8
values | patient_profile stringclasses 8
values | timeline stringclasses 8
values | longitudinal_omics stringclasses 8
values | interventions stringclasses 8
values | response_trajectory stringclasses 8
values | model_narrative stringclasses 8
values | coherence_checks stringclasses 8
values | coherence_label stringclasses 3
values | coherence_failure_signature stringclasses 3
values | constraints stringclasses 1
value | gold_checklist stringclasses 8
values |
|---|---|---|---|---|---|---|---|---|---|---|---|
MOCA-NC-001 | 38F, post-viral dysautonomia | T0 onset; T1 persistent; T2 improved | T0 IFN high, IL-6 high, kynurenine high, diversity low; T2 IFN normal, IL-6 low, kynurenine mid, diversity improved | anti-inflammatory + sleep protocol starting T1 | Orthostatic intolerance + brain fog improve by T2 | Narrative links IFN-driven inflammation to symptoms at T0/T1, and improvement tracks normalization by T2 after intervention | Checks: time alignment; intervention-response alignment; no missing reversal | coherent | none | Under 170 words. | 1 mentions T0/T2; 2 links to response |
MOCA-NC-002 | 45M, bile acid syndrome | T0 baseline; T1 after binder | T0 bile acids distorted, FXR targets low, FGF19 low, bile-tolerant taxa high; T1 bile acids normalize, FXR targets rise | bile acid binder at T0 | Steatorrhea and RUQ pain improve at T1 | Narrative: FXR feedback collapse drives symptoms; binder reduces bile acids and symptoms improve; microbiome shifts follow | Checks: mechanism to symptoms; treatment explains omics shift | coherent | none | Under 170 words. | 1 ties binder to omics and symptoms |
MOCA-NC-003 | 34M, hyperammonemia episodes | T0 after protein meal; T1 after lactulose | T0 ammonia high, urea genes down, urease taxa high; T1 ammonia down | lactulose at T0 | Confusion resolves at T1 | Narrative: gut urease load increases ammonia; urea bottleneck limits clearance; lactulose reduces gut ammonia leading to symptom relief | Checks: intervention explains outcome | coherent | none | Under 170 words. | 1 lactulose explains ammonia drop |
MOCA-NC-004 | 52M, cardiometabolic | T0 baseline; T1 after metformin + weight loss | T0 BCAAs high, insulin signaling down, CRP high, low butyrate taxa; T1 CRP down, insulin signaling improves | metformin + weight loss | A1c improves | Narrative: insulin resistance loop explains T0; intervention improves insulin signaling and inflammation by T1 | Checks: directionality matches | coherent | none | Under 170 words. | 1 correct directions |
MOCA-NC-005 | 29F, mast cell flares | T0 flare; T1 antihistamine; T2 partial improvement | T0 mast cell signature high; T1 histamine proteins lower; methylation markers remain low | antihistamine at T0 | Hives reduce at T1 but fatigue persists | Narrative: antihistamine reduces mediator symptoms but methylation bottleneck maintains background susceptibility, explaining partial response | Checks: partial response explained | coherent | none | Under 170 words. | 1 explains partial |
MOCA-NC-006 | 50F, anemia pattern | T0 baseline; T1 iron trial | T0 ferritin high, heme genes down; T1 ferritin high persists | oral iron at T0 | Symptoms unchanged, nausea worse | Narrative claims iron deficiency and expects improvement at T1 | Checks fail: ferritin high contradicts; response mismatch | incoherent | wrong-mechanism | Under 170 words. | 1 must not expect iron benefit |
MOCA-NC-007 | 27F, immune deficiency | T0 baseline; T1 Ig replacement + diet | T0 IgA low, pathobionts high, SCFAs low; T1 infections reduce, SCFAs rise | Ig replacement + diet | Fewer infections and better stool at T1 | Narrative: immune deficit drives dysbiosis; replacement reduces infections; diet restores SCFA | Checks: sequence matches | coherent | none | Under 170 words. | 1 intervention matches |
MOCA-NC-008 | 46M, unstable symptoms | T0,T1 mixed | No stable longitudinal pattern | multiple trials no response | No clear change | Narrative claims clear causal story and improvement | Checks fail: timeline not supported | posthoc-story | overconfident-timeline | Under 170 words. | 1 should state uncertainty |
What this dataset tests
Whether the biology explains the clinical story across time.
It requires alignment between:
- symptom timeline
- longitudinal omic shifts
- interventions
- response trajectory
Labels
- coherent
- partially-coherent
- incoherent
- posthoc-story
Posthoc-story means the narrative sounds plausible
but does not match the timeline or measurements.
Typical failures
- timepoint inversion
- claiming an intervention caused a shift that occurred earlier
- ignoring non-response
- forcing a story when data is unstable
Suggested prompt wrapper
System
You evaluate clinical–biological narrative coherence.
User
Patient Profile
{patient_profile}
Timeline
{timeline}
Longitudinal Omics
{longitudinal_omics}
Interventions
{interventions}
Response
{response_trajectory}
Model Narrative
{model_narrative}
Return
- one label
- one sentence naming what aligns or conflicts
Citation
ClarusC64 dataset family
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