id stringclasses 6
values | disease_area stringclasses 4
values | basin_profile_summary stringclasses 6
values | invariant_feature_set stringclasses 6
values | mechanism_profile stringclasses 4
values | target_pathways stringclasses 5
values | expected_on_target_effects stringclasses 6
values | known_tradeoffs stringclasses 4
values | match_context stringclasses 6
values | mechanism_basin_match_score float64 0.42 0.85 | responsive_basin_label stringclasses 6
values | predicted_response_vector stringclasses 6
values | coherence_delta float64 0.18 0.76 | off_target_basin_risk stringclasses 2
values | rationale_channels stringclasses 6
values | notes stringclasses 6
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MBM-001 | T2D | metabolic inflammation basin; IR high; fatty liver | IR; TG high; CRP mild; fatty liver; low activity | AMPK agonism (metformin-like) | AMPK up; gluconeogenesis down | HbA1c down; TG down; CRP down | GI intolerance subset | broad metabolic syndrome | 0.82 | metabolic_inflammation_basin | glycemic:+; hepatic:+; inflammation:+; function:+ | 0.7 | low | glycemic; hepatic; inflammation | strong fit | Under 260 words | match+basin+vector+delta+risk+rationale |
MBM-002 | T2D | mitochondrial fatigue basin; HRV low; oxstress up | HRV low; fatigue high; oxstress up; mito down | SGLT2 inhibition | glycosuria up; volume down | HF events down; weight down; mild glycemic gain | volume depletion risk | older; CKD stage2 | 0.64 | partial_fit_basin | renal:+; cardio:+; energy:~ | 0.42 | moderate | renal; cardio; fatigue | mechanism not primary on mito axis | Under 260 words | match+basin+vector+delta+risk+rationale |
MBM-003 | RA | TNF high inflammatory basin; synovitis present | CRP high; synovitis; TNF axis up; pain high | TNF inhibition | TNF down | CRP down; flare down; pain down | infection risk | seropositive RA | 0.85 | TNF_high_inflammatory_basin | CRP:+; synovitis:+; pain:+; function:+ | 0.76 | moderate | inflammation; joint; safety | high coherence gain with tradeoff | Under 260 words | match+basin+vector+delta+risk+rationale |
MBM-004 | RA | neuroimmune pain basin; pain>>CRP | pain>>CRP; IFN up; mood low; minimal synovitis | TNF inhibition | TNF down | CRP may fall; pain uncertain | infection risk | seronegative overlap | 0.42 | low_fit_basin | CRP:+; pain:~; mood:~ | 0.18 | moderate | symptoms; mechanism mismatch | low fit due to non-inflammatory driver | Under 260 words | match+basin+vector+delta+risk+rationale |
MBM-005 | HFpEF | volume stress basin; NTproBNP high; edema | NTproBNP high; edema; BP load; HRV low | SGLT2 inhibition | natriuresis; osmotic diuresis | edema down; HF events down; function up | dehydration risk | frail older | 0.78 | volume_stress_basin | volume:+; cardio:+; renal:+; function:+ | 0.68 | moderate | volume; cardio; safety | good fit with guardrails | Under 260 words | match+basin+vector+delta+risk+rationale |
MBM-006 | IBD | barrier failure basin; IL23 up; diarrhea | diarrhea; barrier genes down; IL23 up; thickening | IL23 blockade | IL23 down | flare down; stool improved; CRP down | infection risk | frequent flares | 0.8 | barrier_failure_basin | stool:+; CRP:+; imaging:+ | 0.66 | moderate | barrier; immune | strong axis match | Under 260 words | match+basin+vector+delta+risk+rationale |
What this dataset tests
Whether a system can match a drug mechanism to a patient basin.
A trial fails when: the mechanism is coherent for one basin and incoherent for others.
Required outputs
- mechanism_basin_match_score
- responsive_basin_label
- predicted_response_vector
- coherence_delta
- off_target_basin_risk
- rationale_channels
Use case
Trial enrichment. Basin selective recruitment. Rescue analysis for failed Phase II.
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