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CPM-001
Vancomycin nephrotoxicity cascade
Vancomycin started without renal dose adjustment
dose_given
Cr rise -> oliguria -> fluid overload -> respiratory distress -> ICU
dose_monitoring; renal_reserve
renal鈥損ulmonary coupling failure
72h
Cr rise ignored at 24h
true
Renal injury propagated systemically
Under 320 words.
path+nodes+coupling
CPM-002
Contrast AKI escalation
Contrast CT without hydration
contrast_administered
AKI -> nausea -> hypotension -> ICU admission
risk_screening; hydration
renal鈥揾emodynamic coupling failure
48h
hypotension unaddressed
true
Single imaging choice cascades
Under 320 words.
path+nodes+coupling
CPM-003
Opioid respiratory collapse
High-dose opioid PCA
opioid_initiation
sedation -> CO2 retention -> hypoxia -> ICU
sedation_monitoring
neuro鈥搑espiratory coupling failure
24h
sedation score trend ignored
true
Fast amplification
Under 320 words.
path+nodes+coupling
CPM-004
C. diff systemic decline
Unnecessary prolonged antibiotics
antibiotic_day5
diarrhea -> dehydration -> AKI -> sepsis
antibiotic_duration_review
GI鈥搑enal鈥搃mmune coupling failure
7d
early diarrhea normalized
true
Slow cascade
Under 320 words.
path+nodes+coupling
CPM-005
Anticoagulation bleed cascade
DOAC overdosed
first_dose
GI bleed -> anemia -> hypotension -> fall -> fracture
dose_check; fall_risk
hematologic鈥搈usculoskeletal coupling failure
96h
Hb drop unaddressed
true
Multiple domains involved
Under 320 words.
path+nodes+coupling
CPM-006
Line infection escalation
Central line not removed
line_day4
bacteremia -> sepsis -> AKI -> shock
line_review; asepsis
infectious鈥揾emodynamic coupling failure
120h
line tenderness missed
true
Protocol drift amplified harm
Under 320 words.
path+nodes+coupling

What this dataset tests

Whether an intelligence system can trace
how a localized clinical failure
propagates into multi-system harm.

Required outputs

  • cascade pathway graph
  • amplification nodes
  • cross-system coupling failures
  • time to escalation
  • escalation acceleration points
  • preventable amplification flags

Use case

Second layer of the Iatrogenic Harm Cascade Library.

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