Datasets:

ClarusC64
/

ABX-PD-005_time_kill_curve_shape_distortion-v0.1

row_id string	series_id string	timepoint_h int64	organism string	strain_id string	antibiotic_name string	antibiotic_class string	drug_conc_mg_L float64	cfu_log10 float64	media string	assay_method string	source_type string	shape_distortion_signal int64	earliest_distortion int64	notes string
ABXPD005-TR-0001	S1	0	Escherichia coli	EC-ATCC25922	meropenem	carbapenem	2	7.2	CAMHB	time_kill	simulated	0	0	baseline
ABXPD005-TR-0002	S1	2	Escherichia coli	EC-ATCC25922	meropenem	carbapenem	2	6.3	CAMHB	time_kill	simulated	0	0	log linear kill
ABXPD005-TR-0003	S1	4	Escherichia coli	EC-ATCC25922	meropenem	carbapenem	2	5.4	CAMHB	time_kill	simulated	0	0	log linear kill
ABXPD005-TR-0004	S1	6	Escherichia coli	EC-ATCC25922	meropenem	carbapenem	2	4.5	CAMHB	time_kill	simulated	0	0	log linear kill
ABXPD005-TR-0005	S1	24	Escherichia coli	EC-ATCC25922	meropenem	carbapenem	2	2.7	CAMHB	time_kill	simulated	0	0	log linear kill
ABXPD005-TR-0006	S2	0	Klebsiella pneumoniae	KP-CLIN061	ceftriaxone	3rd_gen_cephalosporin	16	7.1	CAMHB	time_kill	simulated	0	0	baseline
ABXPD005-TR-0007	S2	2	Klebsiella pneumoniae	KP-CLIN061	ceftriaxone	3rd_gen_cephalosporin	16	5.8	CAMHB	time_kill	simulated	0	0	fast early kill
ABXPD005-TR-0008	S2	4	Klebsiella pneumoniae	KP-CLIN061	ceftriaxone	3rd_gen_cephalosporin	16	5.75	CAMHB	time_kill	simulated	1	1	plateau begins
ABXPD005-TR-0009	S2	6	Klebsiella pneumoniae	KP-CLIN061	ceftriaxone	3rd_gen_cephalosporin	16	5.7	CAMHB	time_kill	simulated	1	0	plateau persists
ABXPD005-TR-0010	S2	24	Klebsiella pneumoniae	KP-CLIN061	ceftriaxone	3rd_gen_cephalosporin	16	6.2	CAMHB	time_kill	simulated	1	0	regrowth late

ABX-PD-005: Time-Kill Curve Shape Distortion

This dataset tests whether you can detect loss of log linear kill coherence.

The curve stops behaving like a clean log linear decline.

It becomes plateaued or multiphasic.

v1 uses

Each row is one timepoint in a time kill series.

Required columns

Run

The scorer detects distortion using

The scorer avoids a common mistake.

It does not call distortion when drug concentration changes too much.