message stringlengths 3 12.9k | message_type stringclasses 3
values | message_id int64 0 2 | conversation_id int64 54.3k 898k | cluster float64 91 91 | __index_level_0__ int64 162k 2.69M |
|---|---|---|---|---|---|
Answer this question truthfully | instruction | 0 | 54,267 | 91 | 162,391 |
Management of AKI following COVID-19 includes antiviral therapies, identifying electrolyte disorders, and intravenous fluid resuscitation. Early diagnosis and treatment of AKI in patients with COVID-19 can avoid the progression of AKI into ESRD and reduce mortality.
Treatment of AKI following COVID-19 includes: Cor... | output | 1 | 54,267 | 91 | 162,392 |
What is the term used to refer to acute kidney injury associated with COVID-19? | input | 2 | 54,267 | 91 | 162,393 |
Please summerize the given abstract to a title | instruction | 0 | 77,249 | 91 | 231,337 |
Robust antimicrobial photodynamic therapy with curcumin-poly (lactic-co-glycolic acid) nanoparticles against COVID-19: A preliminary in vitro study in Vero cell line as a model | output | 1 | 77,249 | 91 | 231,338 |
BACKGROUND: In this study, the ability of antimicrobial photodynamic therapy (aPDT) as a treatment approach and adjuvant therapy using curcumin-poly (lactic-co-glycolic acid) nanoparticles (Cur@PLGA-NPs) to inactivate Coronavirus disease 2019 (COVID-19) in plasma was investigated. Furthermore, to verify whether the qua... | input | 2 | 77,249 | 91 | 231,339 |
Please summerize the given abstract to a title | instruction | 0 | 77,408 | 91 | 231,814 |
Interferon gamma immunotherapy in five critically ill COVID-19 patients with impaired cellular immunity: a case series | output | 1 | 77,408 | 91 | 231,815 |
Background Prolonged SARS-CoV-2 shedding has been described in immunocompromised COVID-19 patients, resulting in protracted disease and poor outcome. Specific therapy to improve viral clearance and outcome for this group of patients is currently unavailable. Methods Five critically ill COVID-19 patients with severe def... | input | 2 | 77,408 | 91 | 231,816 |
Please summerize the given abstract to a title | instruction | 0 | 77,500 | 91 | 232,090 |
Lilly to test baricitinib against COVID-19 | output | 1 | 77,500 | 91 | 232,091 |
Eli Lilly and Company and the US National Institute of Allergy and Infectious Diseases will study baricitinib, a Lilly rheumatoid arthritis drug, as a potential treatment for people with COVID-19 It’s thought that baricitinib’s anti-inflammatory effect could help reduce the cytokine storm that COVID-19 can trigger in p... | input | 2 | 77,500 | 91 | 232,092 |
Please summerize the given abstract to a title | instruction | 0 | 77,656 | 91 | 232,558 |
Alemtuzumab in Covid era | output | 1 | 77,656 | 91 | 232,559 |
BACKGROUND: The SARS-CoV-2 pandemic impact on people with Multiple Sclerosis (pwMS) continues to worry. The disease modifying therapies in pwMS can add a more severe risk of infection when compared to the general population. Alemtuzumab is an anti-CD52 monoclonal antibody and it is one of the most immunosuppressive dru... | input | 2 | 77,656 | 91 | 232,560 |
Please summerize the given abstract to a title | instruction | 0 | 77,776 | 91 | 232,918 |
JAK/STAT Pathway Inhibition May Be a Promising Therapy for COVID-19-Related Hyperinflammation in Hematologic Patients | output | 1 | 77,776 | 91 | 232,919 |
COVID-19 has rapidly become a major concern for the health systems worldwide. Its high contagiousness and associated mortality demand the discovery of helpful interventions with promising safety profile. Here, we report 3 severe COVID-19 cases, which achieved rapid and sustained improvement in outcome with the use of r... | input | 2 | 77,776 | 91 | 232,920 |
Please summerize the given abstract to a title | instruction | 0 | 77,787 | 91 | 232,951 |
Therapeutic safety and efficacy of triple-immunosuppressants versus dual-immunosuppressants in severe-to-critical COVID-19: a prospective cohort study in Bangladesh | output | 1 | 77,787 | 91 | 232,952 |
BACKGROUND: Hyperinflammation-induced respiratory failure is a leading cause of mortality in COVID-19 infection. Immunosuppressants such as, Baricitinib and interleukin inhibitors are the drug-of-choice to suppress cytokine storm in COVID-19. Here, we compared the therapeutic safety and efficacy of triple-immunosuppres... | input | 2 | 77,787 | 91 | 232,953 |
Please summerize the given abstract to a title | instruction | 0 | 77,830 | 91 | 233,080 |
Ribavirin therapy for severe COVID-19: a retrospective cohort study | output | 1 | 77,830 | 91 | 233,081 |
The aim of this study was to compare ribavirin therapy versus supportive therapy only for patients with severe coronavirus disease 2019 (COVID-19). A total of 115 patients with laboratory-confirmed COVID-19 were retrospectively analysed. All patients received supportive care as well as regular laboratory and clinical m... | input | 2 | 77,830 | 91 | 233,082 |
Please summerize the given abstract to a title | instruction | 0 | 77,844 | 91 | 233,122 |
High-Dose Intravenous Immunoglobulin in Severe Coronavirus Disease 2019: A Multicenter Retrospective Study in China | output | 1 | 77,844 | 91 | 233,123 |
Background: The effective treatment of coronavirus disease 2019 (COVID-19) remains unclear. We reported successful use of high-dose intravenous immunoglobulin (IVIg) in cases of severe COVID-19, but evidence from larger case series is still lacking. Methods: A multi-center retrospective study was conducted to evaluate ... | input | 2 | 77,844 | 91 | 233,124 |
Please summerize the given abstract to a title | instruction | 0 | 77,890 | 91 | 233,260 |
Can pulse steroid therapy increase the risk of infection by COVID-19 in patients with multiple sclerosis? | output | 1 | 77,890 | 91 | 233,261 |
BACKGROUND: Iran is one of the countries with a high prevalence of multiple sclerosis (MS) and COVID-19.MS patients receiving the immunomodulatory or immunosuppressive therapy have a higher risk of infection. Due to the significance of determining the risk factors for getting COVID-19 among MS patients, the present stu... | input | 2 | 77,890 | 91 | 233,262 |
Please summerize the given abstract to a title | instruction | 0 | 77,912 | 91 | 233,326 |
Anti-inflammatory effects of GLP-1 in patients with COVID-19 | output | 1 | 77,912 | 91 | 233,327 |
INTRODUCTION: Understanding the pathogenesis and risk factors to control the coronavirus disease 2019 (COVID-19) is necessary. Due to the importance of the inflammatory pathways in the pathogenesis of COVID-19 patients, evaluating the effects of anti-inflammatory medications is important. Glucagon-like peptide 1 recept... | input | 2 | 77,912 | 91 | 233,328 |
Please summerize the given abstract to a title | instruction | 0 | 77,922 | 91 | 233,356 |
A comparison of Remdesivir versus gold cluster in COVID-19 animal model: A better therapeutic outcome of gold cluster | output | 1 | 77,922 | 91 | 233,357 |
While gold compound have been approved for Rheumatoid arthritis treatment as it well suppresses inflammatory cytokines of patients, no such treatment is currently available for COVID-19 treatment in vivo . We firstly disclose gold cluster yields better therapeutic outcome than Remdesivir in COVID-19 hamster treatments ... | input | 2 | 77,922 | 91 | 233,358 |
Please summerize the given abstract to a title | instruction | 0 | 77,961 | 91 | 233,473 |
Maoto, a traditional herbal medicine, for post-exposure prophylaxis for Japanese healthcare workers exposed to COVID-19: A single center study | output | 1 | 77,961 | 91 | 233,474 |
Background Little research has been done on post-exposure prophylaxis (PEP) for COVID-19. This study was done to determine if maoto, a traditional herbal medicine commonly used for diseases with symptoms similar to those of COVID-19, can be repurposed for post-exposure prophylaxis to prevent the spread of nosocomial in... | input | 2 | 77,961 | 91 | 233,475 |
Please summerize the given abstract to a title | instruction | 0 | 77,992 | 91 | 233,566 |
Toxicity of psychotropic drugs in patients with COVID-19: A systematic review | output | 1 | 77,992 | 91 | 233,567 |
OBJECTIVE: Due to the global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), guidance for the use of psychotropic drugs in this context is necessary. We aimed to review clinical evidence regarding the potential toxicity of psychiatric medications in the context of SARS-CoV-2 infection. METHODS: ... | input | 2 | 77,992 | 91 | 233,568 |
Please summerize the given abstract to a title | instruction | 0 | 78,097 | 91 | 233,881 |
Glucocorticoids alone versus tocilizumab alone or glucocorticoids plus tocilizumab in patients with severe SARS-CoV-2 pneumonia and mild inflammation./ Glucocorticoides solos versus tocilizumab solo o glucocorticoides más tocilizumab en pacientes con neumonía grave por SARS-CoV-2 e inflamación moderada | output | 1 | 78,097 | 91 | 233,882 |
AIM: To assess clinical outcomes according to the immunosuppressive treatment administered to patients with severe SARS-CoV-2 pneumonia and moderate inflammation. METHODS: A retrospective observational cohort study involving 142 patients with severe COVID-19 pneumonia and moderate inflammation divided into three treatm... | input | 2 | 78,097 | 91 | 233,883 |
Please summerize the given abstract to a title | instruction | 0 | 78,102 | 91 | 233,896 |
Safety and Effectiveness of High-Dose Vitamin C in Patients with COVID-19;A Randomized Controlled open-label Clinical Trial | output | 1 | 78,102 | 91 | 233,897 |
Background: To assess the effectiveness of vitamin C treatment against coronavirus disease 2019 (COVID-19) Methods: An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lo... | input | 2 | 78,102 | 91 | 233,898 |
Please summerize the given abstract to a title | instruction | 0 | 78,324 | 91 | 234,562 |
Impact of anti-cancer therapy on disease severity and mortality in cancer patients with COVID-19: a systematic review and meta-analysis | output | 1 | 78,324 | 91 | 234,563 |
Background: Cancer patients are more vulnerable to Coronavirus disease-2019 (COVID-19) and have a higher risk of adverse outcomes than the general population. Therefore, it is necessary to evaluate whether anti-cancer therapies such as surgery, chemotherapy, immunotherapy, and targeted therapy will increase the severit... | input | 2 | 78,324 | 91 | 234,564 |
Please summerize the given abstract to a title | instruction | 0 | 78,450 | 91 | 234,940 |
[natural Therapeutic Factors in Medical Rehabilitation of Patients with Post-covid-19 at Outpatient Treatment Stage] | output | 1 | 78,450 | 91 | 234,941 |
The purpose of the research is to study therapeutic efficiency of medical rehabilitation of patients with Post-COVID-19 syndrome at outpatient treatment stage including natural therapeutic factors and phyto products in rehabilitation programme. In Nalchik resort 64 patients suffering from corona virus disease COVID-19 ... | input | 2 | 78,450 | 91 | 234,942 |
Please summerize the given abstract to a title | instruction | 0 | 78,513 | 91 | 235,129 |
Systematic Review and Meta-Analysis of Tocilizumab Administration for the Treatment of Hospitalised Patients with COVID-19 | output | 1 | 78,513 | 91 | 235,130 |
Background: Tocilizumab, an IL-6 inhibitor, has been repurposed against the “cytokine storm” in the setting of COVID-19. In this systematic review and meta-analysis, we evaluated the efficacy of tocilizumab in the management of hospitalised COVID-19.Methods: We searched MEDLINE, CENTRAL and medRxiv for studies of tocil... | input | 2 | 78,513 | 91 | 235,131 |
Please summerize the given abstract to a title | instruction | 0 | 78,649 | 91 | 235,537 |
Evaluation of Ivermectin as a Potential Treatment for Mild to Moderate COVID-19: A Double-Blind Randomized Placebo Controlled Trial in Eastern India. | output | 1 | 78,649 | 91 | 235,538 |
BACKGROUND There has been a growing interest in ivermectin ever since it was reported to have an in-vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This trial was conducted to test the efficacy of ivermectin in mild and moderate coronavirus disease 19 (COVID-19). METHODS A double bl... | input | 2 | 78,649 | 91 | 235,539 |
Please summerize the given abstract to a title | instruction | 0 | 78,776 | 91 | 235,918 |
Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19 | output | 1 | 78,776 | 91 | 235,919 |
The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. We performed a single-center propensity score matched cohort study, including all consecutive COVID-19 patients admitted to a community hospital between 1 March 2020 and... | input | 2 | 78,776 | 91 | 235,920 |
Please summerize the given abstract to a title | instruction | 0 | 78,888 | 91 | 236,254 |
A PHARMACOLOGICAL FRAMEWORK FOR INTEGRATING TREATING THE HOST, REPURPOSING AND THE DAMAGE RESPONSE FRAMEWORK IN COVID‐19 | output | 1 | 78,888 | 91 | 236,255 |
With any new disease a framework for development of preventative or treatment therapeutics is key; the absence of such in COVID‐19 has enabled ineffective and potentially unsafe treatments to be taken up by Governments and clinicians desperate to have options for patients. As we still have few therapies and nil vaccine... | input | 2 | 78,888 | 91 | 236,256 |
Please summerize the given abstract to a title | instruction | 0 | 78,986 | 91 | 236,548 |
LB1. Remdesivir for the Treatment of High-Risk Non-Hospitalized Individuals With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial | output | 1 | 78,986 | 91 | 236,549 |
BACKGROUND: Remdesivir (RDV) is a potent nucleotide prodrug inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase that has demonstrated efficacy in the treatment of patients hospitalized with moderate to severe COVID-19. This Phase 3 (GS-US-540–9012) double-blind, placebo-controlled study compared the efficacy and s... | input | 2 | 78,986 | 91 | 236,550 |
Please summerize the given abstract to a title | instruction | 0 | 78,999 | 91 | 236,587 |
Safety of DW-MSC infusion in patients with low clinical risk COVID-19 infection: a randomized, double-blind, placebo-controlled trial | output | 1 | 78,999 | 91 | 236,588 |
BACKGROUND: Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) have been proposed to have therapeutic potential to improve clinical outcomes in COVID-19. However, the safety and efficacy profile of MSC infusion therapy in patients with non-severe COVID-19 infection has not been completely establish... | input | 2 | 78,999 | 91 | 236,589 |
Please summerize the given abstract to a title | instruction | 0 | 79,065 | 91 | 236,785 |
Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial) | output | 1 | 79,065 | 91 | 236,786 |
OBJECTIVE: To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India. DESIGN: Open label, parallel arm, phase II, multicentre, randomised controlled trial. SETTING: 39 public and private hospitals across India. PARTICIPANTS: 464 adults (≥18 ye... | input | 2 | 79,065 | 91 | 236,787 |
Please summerize the given abstract to a title | instruction | 0 | 79,308 | 91 | 237,514 |
Aerosolized nanoliposomal carrier of remdesivir: an effective alternative for COVID-19 treatment in vitro | output | 1 | 79,308 | 91 | 237,515 |
Aim: To formulate an aerosolized nanoliposomal carrier for remdesivir (AL-Rem) against coronavirus disease 2019. Methods: AL-Rem was prepared using modified hydration technique. Cytotoxicity in lung adenocarcinoma cells, stability and aerodynamic characteristics of developed liposomes were evaluated. Results: AL-Rem sh... | input | 2 | 79,308 | 91 | 237,516 |
Please summerize the given abstract to a title | instruction | 0 | 79,316 | 91 | 237,538 |
Antipsychotic-Induced Immune Dysfunction: A Consideration for COVID-19 Risk | output | 1 | 79,316 | 91 | 237,539 |
Patients with severe mental illness are more susceptible to infections for a variety of reasons, some associated with the underlying disease and some due to environmental factors including housing insecurity, smoking, poor access to healthcare, and medications used to treat these disorders. This increased susceptibilit... | input | 2 | 79,316 | 91 | 237,540 |
Please summerize the given abstract to a title | instruction | 0 | 79,555 | 91 | 238,255 |
Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications | output | 1 | 79,555 | 91 | 238,256 |
Objectives: Remdesivir has shown promise in the management of patients with COVID-19 although recent studies have shown concerns with its effectiveness in practice. Despite this there is a need to document potential adverse drug events (ADEs) to guide future decisions as limited ADE data available before the COVID-19 p... | input | 2 | 79,555 | 91 | 238,257 |
Please summerize the given abstract to a title | instruction | 0 | 79,569 | 91 | 238,297 |
Efficacy of Brazilian Green Propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial | output | 1 | 79,569 | 91 | 238,298 |
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes challenging immune and inflammatory phenomena. Though various therapeutic possibilities have been tested against coronavirus disease 2019 (COVID-19), the most adequate treatment has not yet been established. Propolis is a natural product ... | input | 2 | 79,569 | 91 | 238,299 |
Please summerize the given abstract to a title | instruction | 0 | 79,576 | 91 | 238,318 |
Hospital admissions in inflammatory rheumatic diseases during the COVID-19 pandemic: incidence and role of disease modifying agents | output | 1 | 79,576 | 91 | 238,319 |
Background: In this pandemia, it is essential for rheumatologist and patients to know the relationship between COVID-19 and inflammatory rheumatic diseases (IRD). We want to assess the role of targeted synthetic or biologic disease modifying antirheumatic drugs (ts/bDMARDs) and other variables in the development of mod... | input | 2 | 79,576 | 91 | 238,320 |
Please summerize the given abstract to a title | instruction | 0 | 79,677 | 91 | 238,621 |
Association Between Treatments and Short-Term Biochemical Improvements and Clinical Outcomes in Post-Severe Acute Respiratory Syndrome Coronavirus-2 Inflammatory Syndrome | output | 1 | 79,677 | 91 | 238,622 |
OBJECTIVES: To 1) analyze the short-term biochemical improvements and clinical outcomes following treatment of children with post-severe acute respiratory syndrome coronavirus-2 inflammatory syndrome (multisystem inflammatory syndrome in children/pediatric inflammatory multisystem syndrome temporally associated with se... | input | 2 | 79,677 | 91 | 238,623 |
Please summerize the given abstract to a title | instruction | 0 | 79,730 | 91 | 238,780 |
The potential health and economic impact of dexamethasone treatment for patients with COVID-19 | output | 1 | 79,730 | 91 | 238,781 |
Dexamethasone has been shown to reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment would be rolled out in the UK and globally, as well as its cost-effectiveness of i... | input | 2 | 79,730 | 91 | 238,782 |
Please summerize the given abstract to a title | instruction | 0 | 79,758 | 91 | 238,864 |
Antibiotic Prescribing Patterns at COVID-19 Dedicated Wards in Bangladesh: Findings from a Single Center Study | output | 1 | 79,758 | 91 | 238,865 |
Background: As evidence is mounting regarding irrational and often unnecessary use of antibiotics during the COVID-19 pandemic a cross-sectional Point Prevalence Survey (PPS) (in accordance with WHO guideline) was conducted across COVID-19 dedicated wards in Dhaka Medical College and Hospital (DMCH). Methodology: Antib... | input | 2 | 79,758 | 91 | 238,866 |
Please summerize the given abstract to a title | instruction | 0 | 79,760 | 91 | 238,870 |
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