message stringlengths 4 6.09k | message_type stringclasses 3
values | message_id int64 0 2 | conversation_id int64 52.9k 898k | cluster float64 62 62 | __index_level_0__ int64 158k 2.69M |
|---|---|---|---|---|---|
Answer this question truthfully | instruction | 0 | 52,911 | 62 | 158,323 |
The CDC recommends that priority for collection and real-time RT-PCR testing should be given to lower respiratory tract specimens. Lower respiratory specimen testing appears to be more sensitive in the detection of MERS-CoV, when compared to specimens from the upper respiratory tract. It is recommended the collect... | output | 1 | 52,911 | 62 | 158,324 |
What are the laboratory results for a Middle East respiratory syndrome coronavirus infection? | input | 2 | 52,911 | 62 | 158,325 |
Please summerize the given abstract to a title | instruction | 0 | 77,342 | 62 | 231,616 |
SARS-CoV-2 RNA detection and persistence in wastewater samples: An experimental network for COVID-19 environmental surveillance in Padua, Veneto Region (NE Italy) | output | 1 | 77,342 | 62 | 231,617 |
Background Clinical detection of SARS-CoV-2 RNA in stools supports the idea of wastewater-based epidemiology (WBE) as a precious tool for COVID-19 environmental surveillance. Successful detection of SARS-CoV-2 RNA in untreated wastewaters has been reported in several countries. This study investigated the presence and ... | input | 2 | 77,342 | 62 | 231,618 |
Please summerize the given abstract to a title | instruction | 0 | 77,524 | 62 | 232,162 |
Performance of the Innova SARS-CoV-2 antigen rapid lateral flow test in the Liverpool asymptomatic testing pilot: population based cohort study | output | 1 | 77,524 | 62 | 232,163 |
OBJECTIVE: To assess the performance of the SARS-CoV-2 antigen rapid lateral flow test (LFT) versus polymerase chain reaction testing in the asymptomatic general population attending testing centres. DESIGN: Observational cohort study. SETTING: Community LFT pilot at covid-19 testing sites in Liverpool, UK. PARTICIPANT... | input | 2 | 77,524 | 62 | 232,164 |
Please summerize the given abstract to a title | instruction | 0 | 77,559 | 62 | 232,267 |
Investigation of potential safety hazards during medical waste disposal in SARS-CoV-2 testing laboratory | output | 1 | 77,559 | 62 | 232,268 |
This study aims to investigate the potential safety hazards and provide reference for improving the medical waste disposal procedure in SARS-CoV-2 testing laboratory. Our SARS-CoV-2 testing group detected the RNA residue on the surface of medical waste with Droplet Digital PCR, and held a meeting to discuss the risks i... | input | 2 | 77,559 | 62 | 232,269 |
Please summerize the given abstract to a title | instruction | 0 | 77,578 | 62 | 232,324 |
Validating and optimizing the method for molecular detection and quantification of SARS-CoV-2 in wastewater | output | 1 | 77,578 | 62 | 232,325 |
Wastewater surveillance of SARS-CoV-2 has become a promising tool to estimate population-level changes in community infections and the prevalence of COVID-19 disease. Although many studies have reported the detection and quantification of SARS-CoV-2 in wastewater, remarkable variation remains in the methodology. In thi... | input | 2 | 77,578 | 62 | 232,326 |
Please summerize the given abstract to a title | instruction | 0 | 77,772 | 62 | 232,906 |
Sensitive quantitative detection of SARS-CoV-2 in clinical samples using digital warm-start CRISPR assay | output | 1 | 77,772 | 62 | 232,907 |
Quantifying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in clinical samples is crucial for early diagnosis and timely medical treatment of coronavirus disease 2019. Here, we describe a digital warm-start CRISPR (dWS-CRISPR) assay for sensitive quantitative detection of SARS-CoV-2 in clinical samples. T... | input | 2 | 77,772 | 62 | 232,908 |
Please summerize the given abstract to a title | instruction | 0 | 78,479 | 62 | 235,027 |
Uncertainties in estimating SARS-CoV-2 prevalence by wastewater-based epidemiology | output | 1 | 78,479 | 62 | 235,028 |
Wastewater-based epidemiology (WBE) is a promising approach for estimating population-wide COVID-19 prevalence through detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater However, various methodological challenges associated with WBE would affect the accuracy of prevalence estima... | input | 2 | 78,479 | 62 | 235,029 |
Please summerize the given abstract to a title | instruction | 0 | 78,728 | 62 | 235,774 |
Correlation of SARS-CoV-2 nucleocapsid antigen and RNA concentrations in nasopharyngeal samples from children and adults using an ultrasensitive and quantitative antigen assay | output | 1 | 78,728 | 62 | 235,775 |
Background: Diagnosis of COVID-19 by PCR offers high sensitivity, but the utility of detecting samples with high cycle threshold (Ct) values remains controversial. Currently available rapid diagnostic tests (RDTs) for SARS-CoV-2 nucleocapsid antigens (Ag) have sensitivity well below PCR. The correlation of Ag and RNA q... | input | 2 | 78,728 | 62 | 235,776 |
Please summerize the given abstract to a title | instruction | 0 | 78,738 | 62 | 235,804 |
Validation of the RT-LAMP assay in a large cohort of nasopharyngeal swab samples shows that it is a useful screening method for detecting SARS-CoV-2 and its VOC variants | output | 1 | 78,738 | 62 | 235,805 |
The COVID-19 pandemic is challenging the global supply chain and equipment needed for mass testing with RT-qPCR, the gold standard for SARS-CoV-2 diagnosis. Here, we propose the RT-LAMP assay as an additional strategy for rapid virus diagnosis. However, its validation as a diagnostic method remains uncertain. In this w... | input | 2 | 78,738 | 62 | 235,806 |
Please summerize the given abstract to a title | instruction | 0 | 78,935 | 62 | 236,395 |
Detection of SARS-CoV-2 variants by Abbott molecular, antigen, and serological tests | output | 1 | 78,935 | 62 | 236,396 |
BACKGROUND: : Viral diversity presents an ongoing challenge for diagnostic tests, which need to accurately detect all circulating variants. The Abbott Global Surveillance program monitors severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and their impact on diagnostic test performance. OBJECTIVES: :... | input | 2 | 78,935 | 62 | 236,397 |
Please summerize the given abstract to a title | instruction | 0 | 79,052 | 62 | 236,746 |
SARS-CoV-2 Viral RNA Is Detected in the Bone Marrow in Post-Mortem Samples Using RT-LAMP | output | 1 | 79,052 | 62 | 236,747 |
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, viral RNA has been detected in several different human tissues and organs. This study reports the detection of SARS-CoV-2 RNA in the bone marrow. Post-mortem samples were taken in a sterile manner during two forensic autop... | input | 2 | 79,052 | 62 | 236,748 |
Please summerize the given abstract to a title | instruction | 0 | 79,092 | 62 | 236,866 |
Patterns of SARS-CoV-2 testing preferences in a national cohort in the United States | output | 1 | 79,092 | 62 | 236,867 |
In order to understand preferences about SARS-CoV-2 testing, we conducted a discrete choice experiment among 4793 participants in the Communities, Households, and SARS-CoV-2 Epidemiology (CHASING COVID) Cohort Study from July 30-September 8, 2020. We used latent class analysis to identify distinct patterns of preferenc... | input | 2 | 79,092 | 62 | 236,868 |
Please summerize the given abstract to a title | instruction | 0 | 79,186 | 62 | 237,148 |
Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples | output | 1 | 79,186 | 62 | 237,149 |
We analyzed feasibility of pooling saliva samples for severe acute respiratory syndrome coronavirus 2 testing and found that sensitivity decreased according to pool size: 5 samples/pool, 7.4% reduction; 10 samples/pool, 11.1%; and 20 samples/pool, 14.8%. When virus prevalence is >2.6%, pools of 5 require fewer tests; w... | input | 2 | 79,186 | 62 | 237,150 |
Please summerize the given abstract to a title | instruction | 0 | 79,188 | 62 | 237,154 |
Fast and real-time electrical transistor assay for quantifying SARS-CoV-2 neutralizing antibodies | output | 1 | 79,188 | 62 | 237,155 |
Due to the SARS-CoV-2 pandemic renewed attention has been directed towards viral neutralization assays and neutralizing antibodies quantification, for vaccine pre-clinical trials and determining vaccine efficacy over time. The gold standard to assess antibody titer is the plaque reduction neutralization test, an end-po... | input | 2 | 79,188 | 62 | 237,156 |
Please summerize the given abstract to a title | instruction | 0 | 79,198 | 62 | 237,184 |
Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2 | output | 1 | 79,198 | 62 | 237,185 |
The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance amo... | input | 2 | 79,198 | 62 | 237,186 |
Please summerize the given abstract to a title | instruction | 0 | 79,204 | 62 | 237,202 |
Quantification of mRNA Expression Using Single-Molecule Nanopore Sensing | output | 1 | 79,204 | 62 | 237,203 |
[Image: see text] RNA quantification methods are broadly used in life science research and in clinical diagnostics. Currently, real-time reverse transcription polymerase chain reaction (RT-qPCR) is the most common analytical tool for RNA quantification. However, in cases of rare transcripts or inhibiting contaminants i... | input | 2 | 79,204 | 62 | 237,204 |
Please summerize the given abstract to a title | instruction | 0 | 79,322 | 62 | 237,556 |
Time-evolution of SARS-CoV-2 in wastewater during the first pandemic wave of COVID-19 in the metropolitan area of Barcelona | output | 1 | 79,322 | 62 | 237,557 |
Two large wastewater treatment plants (WWTP), covering around 2.7 M inhabitants, which represents around 85% of the metropolitan area of Barcelona, were sampled before, during and after the implementation of a complete lockdown. Five one-step RT-qPCR assays, targeting the polymerase (IP2 and IP4), the envelope E and th... | input | 2 | 79,322 | 62 | 237,558 |
Please summerize the given abstract to a title | instruction | 0 | 79,334 | 62 | 237,592 |
Evaluating recovery, cost, and throughput of different concentration methods for SARS-CoV-2 wastewater-based epidemiology | output | 1 | 79,334 | 62 | 237,593 |
As the COVID-19 pandemic continues to affect communities across the globe, the need to contain the spread of the outbreaks is of paramount importance. Wastewater monitoring of the SARS-CoV-2 virus, the causative agent responsible for COVID-19, has emerged as a promising tool for health officials to anticipate outbreaks... | input | 2 | 79,334 | 62 | 237,594 |
Please summerize the given abstract to a title | instruction | 0 | 79,614 | 62 | 238,432 |
[Recording of SARS-CoV-2 laboratory tests in Germany]./ Erfassung der Labortestungen auf SARS-CoV-2 in Deutschland | output | 1 | 79,614 | 62 | 238,433 |
The collection of data on SARS-CoV2 tests is central to the assessment of the infection rate in the context of the COVID-19 pandemic. At the Robert Koch Institute (RKI), data collected from various laboratory data recording systems are consolidated. First, this article aims to exemplify significant aspects regarding t... | input | 2 | 79,614 | 62 | 238,434 |
Please summerize the given abstract to a title | instruction | 0 | 79,776 | 62 | 238,918 |
Evaluation of an Automated High-Throughput Liquid-Based RNA Extraction Platform on Pooled Nasopharyngeal or Saliva Specimens for SARS-CoV-2 RT-PCR | output | 1 | 79,776 | 62 | 238,919 |
SARS-CoV-2 RT-PCR with pooled specimens has been implemented during the COVID-19 pandemic as a cost- and manpower-saving strategy for large-scale testing. However, there is a paucity of data on the efficiency of different nucleic acid extraction platforms on pooled specimens. This study compared a novel automated high-... | input | 2 | 79,776 | 62 | 238,920 |
Please summerize the given abstract to a title | instruction | 0 | 79,783 | 62 | 238,939 |
Exploring beyond the limit: how comparative stochastic performance affects retesting outcomes in six commercial SARS CoV-2 nucleic acid amplification tests | output | 1 | 79,783 | 62 | 238,940 |
OBJECTIVES: : To examine the comparative stochasticity profile of six commercial SARS-CoV-2 nucleic acid amplification tests (NAATs) and how this may affect retesting paradigms. METHODS: : Commercial quality control (QC) material was serially diluted in viral transport media to create a panel covering 10 – 10,000 copie... | input | 2 | 79,783 | 62 | 238,941 |
Please summerize the given abstract to a title | instruction | 0 | 79,897 | 62 | 239,281 |
Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs | output | 1 | 79,897 | 62 | 239,282 |
The gold standard method in the diagnosis of SARS-CoV-2 infection is the detection of viral RNA in the nasopharyngeal sample by RT-PCR. Recently, saliva samples have been suggested as an alternative sample. In the present study, we aimed to compare RT-PCR results in nasopharyngeal, oro-nasopharyngeal and saliva samples... | input | 2 | 79,897 | 62 | 239,283 |
Please summerize the given abstract to a title | instruction | 0 | 79,980 | 62 | 239,530 |
Real-time optical analysis of a colorimetric LAMP assay for SARS-CoV-2 in saliva with a handheld instrument improves accuracy compared to endpoint assessment | output | 1 | 79,980 | 62 | 239,531 |
Controlling the course of the COVID-19 pandemic will require widespread deployment of consistent and accurate diagnostic testing of the novel coronavirus SARS-CoV-2. Ideally, tests should detect a minimum viral load, be minimally invasive, and provide a rapid and simple readout. Current FDA-approved RT-qPCR-based stand... | input | 2 | 79,980 | 62 | 239,532 |
Please summerize the given abstract to a title | instruction | 0 | 80,054 | 62 | 239,752 |
Evaluation of the test accuracy of a SARS-CoV-2 rapid antigen test in symptomatic community dwelling individuals in the Netherlands | output | 1 | 80,054 | 62 | 239,753 |
BACKGROUND: SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is well suited for the diagnosis of clinically ill patients requiring treatment. Application for community testing of symptomatic individuals for disease control purposes however raises challenges. SARS-CoV-2 rapid antigen tests ... | input | 2 | 80,054 | 62 | 239,754 |
Please summerize the given abstract to a title | instruction | 0 | 80,096 | 62 | 239,878 |
Two-Step Reverse Transcription Droplet Digital PCR Protocols for SARS-CoV-2 Detection and Quantification. | output | 1 | 80,096 | 62 | 239,879 |
Diagnosis of the ongoing SARS-CoV-2 pandemic is a priority for all countries across the globe. Currently, reverse transcription quantitative PCR (RT-qPCR) is the gold standard for SARS-CoV-2 diagnosis as no permanent solution is available. However effective this technique may be, research has emerged showing its limita... | input | 2 | 80,096 | 62 | 239,880 |
Please summerize the given abstract to a title | instruction | 0 | 80,166 | 62 | 240,088 |
Optical imaging spectroscopy for rapid, primary screening of SARS-CoV-2: a proof of concept | output | 1 | 80,166 | 62 | 240,089 |
Effective testing is essential to control the coronavirus disease 2019 (COVID-19) transmission. Here we report a-proof-of-concept study on hyperspectral image analysis in the visible and near-infrared range for primary screening at the point-of-care of SARS-CoV-2. We apply spectral feature descriptors, partial least sq... | input | 2 | 80,166 | 62 | 240,090 |
Please summerize the given abstract to a title | instruction | 0 | 80,203 | 62 | 240,199 |
Nested pool testing strategy for the reliable identification of individuals infected with SARS-CoV-2 | output | 1 | 80,203 | 62 | 240,200 |
The progress of the SARS-CoV-2 pandemic requires the design of cost-effective testing programs at large scale. To this end, pooling multiple samples can provide a solution. Defining a cost-effective strategy requires the establishment of an efficient deconvolution and re-testing procedure that eventually allows the ide... | input | 2 | 80,203 | 62 | 240,201 |
Please summerize the given abstract to a title | instruction | 0 | 80,222 | 62 | 240,256 |
Immunoassay of SARS-CoV-2 nucleocapsid proteins using novel red emission-enhanced carbon dot-based silica spheres | output | 1 | 80,222 | 62 | 240,257 |
It is imminent to develop a new type of rapid COVID-19 detection method with high sensitivity. Here, we used novel red emission-enhanced carbon dot (CD)-based silica (RCS) spheres as the signals of lateral flow immunochromatography (LFI) to ultrasensitively detect novel severe acute respiratory syndrome coronavirus 2 n... | input | 2 | 80,222 | 62 | 240,258 |
Please summerize the given abstract to a title | instruction | 0 | 80,231 | 62 | 240,283 |
Comparison of saliva and oro-nasopharyngeal swab sample in the molecular diagnosis of COVID-19. | output | 1 | 80,231 | 62 | 240,284 |
BACKGROUND Healthcare personnel are at risk of becoming infected while taking upper and/or lower respiratory tract specimens. Therefore, there is a need for sampling methods that do not risk infecting them. In this study, we aimed to compare the saliva and Oro-Nasopharyngeal Swab (ONS) sampling methods. METHODS Patient... | input | 2 | 80,231 | 62 | 240,285 |
Please summerize the given abstract to a title | instruction | 0 | 80,248 | 62 | 240,334 |
Same-day SARS-CoV-2 antigen test screening in an indoor mass-gathering live music event: a randomised controlled trial | output | 1 | 80,248 | 62 | 240,335 |
BACKGROUND: The banning of mass-gathering indoor events to prevent SARS-CoV-2 spread has had an important effect on local economies. Despite growing evidence on the suitability of antigen-detecting rapid diagnostic tests (Ag-RDT) for mass screening at the event entry, this strategy has not been assessed under controlle... | input | 2 | 80,248 | 62 | 240,336 |
Please summerize the given abstract to a title | instruction | 0 | 80,254 | 62 | 240,352 |
Visual naked-eye detection of SARS-CoV-2 RNA based on covalent organic framework capsules | output | 1 | 80,254 | 62 | 240,353 |
The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted that new diagnosis technologies are crucial for controlling the spread of the disease. Especially in the resources-limit region, conveniently operated detection methods ... | input | 2 | 80,254 | 62 | 240,354 |
Please summerize the given abstract to a title | instruction | 0 | 80,371 | 62 | 240,703 |
Saliva as a Reliable Sample for COVID-19 Diagnosis in Paediatric Patients | output | 1 | 80,371 | 62 | 240,704 |
Saliva has been described a less invasive and easy to handle sample, compared to nasopharyngeal swabs (NPS), in the diagnosis of COVID-19 in adults. Although the advantages of using saliva is still more evident in paediatric patients, little is now about its sensitivity in this group. The aim of this study was to compa... | input | 2 | 80,371 | 62 | 240,705 |
Please summerize the given abstract to a title | instruction | 0 | 80,527 | 62 | 241,171 |
Will the extraction of COVID-19 from wastewater help flatten the curve? | output | 1 | 80,527 | 62 | 241,172 |
With the potentially fatal effect of COVID-19 and its devastating impact on economies worldwide, some environmental scientist has suggested the use of waste from household sewage to trace the movement of SARS-CoV-2, within a given country. However, this approach is not without challenges where developing countries lack... | input | 2 | 80,527 | 62 | 241,173 |
Please summerize the given abstract to a title | instruction | 0 | 80,584 | 62 | 241,342 |
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