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Previous coronavirus infections are detected using serologic assays. Serologic assays are blood tests that detect the presence of antibodies against a particular virus. When a person is infected with a virus, their immune system produces antibodies to figh... | How are previous coronavirus infections detected? |
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Laboratory confirmation of infection by MERS-CoV requires either a positive PCR test of ≥2 specific genomic targets or a single positive target followed by successful sequencing of a second. For the routine detection of MERS-CoV, three rRT-PCR assays have ... | What are the other diagnostic tests that can be conducted for Middle East respiratory syndrome coronavirus infection? |
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Carbon dots for virus detection and therapy
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| Recent experience with the COVID-19 pandemic should be a lesson learnt with respect to the effort we have to invest in the development of new strategies for the treatment of viral diseases, along with their cheap, easy, sensitive, and selective detection. Since we live in a globalized world where just hours can play a ... |
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A Large-Scale Clinical Validation Study Using nCapp Cloud Plus Terminal by Frontline Doctors for the Rapid Diagnosis of COVID-19 and COVID-19 pneumonia in China
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| Background The outbreak of coronavirus disease 2019 (COVID-19) has become a global pandemic acute infectious disease, especially with the features of possible asymptomatic carriers and high contagiousness. It causes acute respiratory distress syndrome and results in a high mortality rate if pneumonia is involved. Curre... |
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Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results
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| BACKGROUND: To face the current COVID-19 pandemic, diagnostic tools are essential. It is recommended to use real-time RT-PCR for RNA viruses in order (a) to perform a rapid and accurate diagnostic, (b) to guide patient care and management and (c) to guide epidemiological strategies. Further studies are warranted to def... |
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The diagnostic accuracy of RT-PCR from self-collected saliva versus nasopharyngeal sampling: A systematic review and meta-analysis
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| OBJECTIVES: To evaluate the diagnostic utility of self-collected saliva in coronavirus desease-19 (COVID-19) screening procedures. METHODS: A total of 6 databases were reviewed from their inception until August 2021. Sensitivity and specificity were measured by extracting items (true-positive, true-negative, false-posi... |
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Miniaturized Label-free Smartphone Assisted Electrochemical Sensing Approach for Personalized COVID-19 Diagnosis
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| The COVID-19, coronavirus disease is an infectious disease caused by a novel virus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) By March 2020 the novel coronavirus known to cause a pandemic has infected nearly about 119 thousand people and killed more than 4,300 around 114 countries Apart from th... |
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COVID-19 rapid diagnostic test could contain transmission in low- and middle-income countries
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| BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has impacted heavily on global health. Although real-time polymerase chain reaction (RT-PCR) is the current diagnostic method, challenges for low- and middle-income countries (LMICs) necessitate cheape... |
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Food Safety in Post-COVID-19 Pandemic: Challenges and Countermeasures
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| Understanding food safety hazard risks is essential to avoid potential negative heath impacts in the food supply chain in a post-COVID-19 pandemic era. Development of strategies for virus direction in foods plays an important role in food safety and verification. Early warning, tracing, and detection should be implemen... |
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Nasopharyngeal swab collection in the suspicion of Covid-19
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| RT-PCR detection of SARS-CoV-2 mRNA on nasopharyngeal swab is the standard for diagnosing active Covid-19 disease in asymptomatic subjects and in symptomatic patients without the typical radiological findings. Nasopharyngeal swabbing appears a trivial procedure, still an inappropriate nasopharyngeal sampling, performed... |
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Pool Testing for COVID-19: Suitable Splitting Procedure and Pool Size for India
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| INTRODUCTION: The COVID-19 has emerged as a global pandemic for public health due to large scale outbreak, therefore there is an urgent need to detect the infected cases quickly and isolate them in order to suppress the further spread of the disease. This study tries to identify a suitable pool testing method and algor... |
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Applications of laboratory findings in the prevention, diagnosis, treatment, and monitoring of COVID-19
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| The worldwide pandemic of coronavirus disease 2019 (COVID-19) presents us with a serious public health crisis. To combat the virus and slow its spread, wider testing is essential. There is a need for more sensitive, specific, and convenient detection methods of the severe acute respiratory syndrome coronavirus 2 (SARS-... |
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Jal Neti Sample for COVID Detection: A Novel Hypothesis
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| The current standard method of diagnosing COVID status has low sensitivity which led the authors to ponder on alternative ways of taking the sample. Various studies have explored the role of nasal wash, a sample taken by injecting and aspirating saline with the help of a syringe but to the best of our knowledge, the us... |
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[Oro- and Nasopharyngeal Swab for Detection of SARS-CoV-2 - Step-by-step Approach]./ Oro- und nasopharyngealer Abstrich Schritt für Schritt
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| Oro- and nasopharyngeal swab specimens by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) to detect SARS-CoV-2 is currently the main diagnostic tool during the ongoing COVID-19 pandemia. Accurate performance of the procedure to avoid false negative results, adequate personal protective equipment a... |
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Implementation of an Emergency Use Authorization Test During an Impending National Crisis
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| The laboratory response to the current severe acute respiratory syndrome coronavirus 2 pandemic may be termed heroic. From the identification of the novel coronavirus to implementation of routine laboratory testing around the world to the development of potential vaccines, laboratories have played a critical role in th... |
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Super-Resolution Optical Microscopy to Detect Viruses (SARS-CoV-2) in Real Time
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| This article describes the use of evanescent light fields to directly observe and detect the newly discovered coronavirus SARS-CoV-2 that causes COVID-19. The proposed technique provides a low-cost, fast, and highly accurate method of detection. This approach builds from previous work from the authors that enables micr... |
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Diagnostic Techniques for COVID-19: A Mini-review of Early Diagnostic Methods
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| The outbreak of severe pneumonia at the end of 2019 was proved to be caused by the SARS-CoV-2 virus spreading out the world. And COVID-19 spread rapidly through a terrible transmission way by human-to-human, which led to many suspected cases waiting to be diagnosed and huge daily samples needed to be tested by an effec... |
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New insights into application of nanoparticles in the diagnosis and screening of novel coronavirus (SARS-CoV-2)
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| Novel coronavirus disease 2019 (COVID-19) is by far the worst pandemic disease in the current millennium. The first human-to-human transmission was observed in December 2019 in China and is caused by the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected millions of peopl... |
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Prolonged Virus Shedding Even after Seroconversion in a Patient with COVID-19
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| • Prolonged virus shedding could be found among COVID-19 patients after clinical symptoms resolved and specific antibody emerged. • Viral detection from throat gargling sample could be an alternative diagnostic method for mild COVID-19 patients with scarce sputum. • Sputum remained the most sensitive specimen for viral... |
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A 5-min RNA preparation method for COVID-19 detection with RT-qPCR
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| RNA extraction has become a bottleneck for detection of COVID-19, in part because of reagent shortages. We present here a rapid protocol that circumvents the need for RNA extraction that is compatible with RT-qPCR-based detection methods. |
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Evaluation of the basic assay performance of the GeneSoc® rapid PCR testing system for detection of severe acute respiratory syndrome coronavirus 2
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| In the ongoing coronavirus disease 2019 (COVID-19) pandemic, PCR has been widely used for screening patients displaying relevant symptoms. The rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enables prompt diagnosis and the implementation of proper precautionary and isolation measures fo... |
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Design of an effective piezoelectric microcantilever biosensor for rapid detection of COVID-19
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| Acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19, is one of the most contagious viruses resulting in a progressive pandemic. Since specific antiviral treatments have not been developed yet and its fatal rate is almost high, early and fast detection is critical for controlling the outbreak. In... |
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Rapid development of COVID-19 rapid diagnostics for low resource settings: accelerating delivery through transparency, responsiveness, and open collaboration
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| In January, Mologic, embarked on a product development pathway for COVID-19 diagnostics focusing on ELISA and rapid diagnostic tests (RDTs), with anticipated funding from Wellcome Trust and DFID. 755 clinical samples from known COVID-19 patients and hospital negative controls were tested on Mologics IgG ELISA. The repo... |
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Clinical laboratory evaluation of COVID-19
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| COVID-19, caused by SARS-CoV-2, is a highly infectious disease, and clinical laboratory detection has played important roles in its diagnosis and in evaluating progression of the disease. Nucleic acid amplification testing or gene sequencing can serve as pathogenic evidence of COVID-19 diagnosing for clinically suspect... |
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Comparative Cost-Effectiveness of SARS-CoV-2 Testing Strategies
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| Background: To mitigate the coronavirus pandemic that emerged in 2019 (COVID-19), countries worldwide have enacted unprecedented movement restrictions, social distancing measures, and face mask requirements. Until safe and efficacious vaccines or antiviral drugs become widely available, viral testing remains the primar... |
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The Sky Has Its Limits in COVID-19 Testing
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| At the time of writing, in July 2020, the COVID-19 pandemic has already inflicted dramatic international restrictions, including airports closing and limiting international travel It has been suggested that re-opening of airports should involve and even rely on testing travelers for COVID-19 This paper discusses the me... |
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An electrochemical biosensor for sensitive analysis of the SARS-CoV-2 RNA
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| The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is continuously worsening globally, herein we have proposed an electrochemical biosensor for the sensitive monitoring of SARS-CoV-2 RNA. The presence of target RNA firstly triggers the catalyti... |
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Too Slow, Less Dough for SARS-CoV-2 Tests? A Micro-Comic Strip
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| Laboratory testing for SARS-CoV-2 has been delayed in some laboratories due to high demand for testing and supply shortages. This has led to proposals and plans that reimbursement for delayed results be reduced or not paid at all (1, 2). Read the comic strip to find out more. |
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Recent developments and trends of automatic nucleic acid detection systems
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| Nucleic acid detection, widely used in clinical diagnosis, biological analysis, and environmental monitoring, is of great significance for disease diagnosis and basic research. With the outbreak of COVID-19, the demand for fast and high-throughput nucleic acid detection from large numbers of samples has increased sharp... |
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Meta-analysis of diagnostic tests for the detection of COVID-19
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| Background: COVID-19 disease emerged at the end of 2019 and it started to be considered a pandemic at the beginning of 2020. The reference methodology for the COVID-19 diagnosis is the RT-qPCR. |
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Coronavirus discovery by metagenomic sequencing: a tool for pandemic preparedness
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| INTRODUCTION: The SARS-CoV-2 pandemic of 2020 is a prime example of the omnipresent threat of emerging viruses that can infect humans. A protocol for the identification of novel coronaviruses by viral metagenomic sequencing in diagnostic laboratories may contribute to pandemic preparedness. AIM: The aim of this study i... |
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Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art
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| Last few decades, viruses are a real menace to human safety. Therefore, the rapid identification of viruses should be one of the best ways to prevent an outbreak and important implications for medical healthcare. The recent outbreak of coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered... |
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Screening test for COVID-19 in dental practice: best options
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| Purpose: To review diverse tests that could serve as a screening tool for the dental community to identify patients with potential COVID-19. |
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SaliVISION: a rapid saliva-based COVID-19 screening and diagnostic test with high sensitivity and specificity
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| The Coronavirus disease 2019 (COVID-19) pandemic-caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)– has posed a global threat and presented with it a multitude of economic and public-health challenges. Establishing a reliable means of readily available, rapid diagnostic testing is of paramount ... |
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[Laboratory testing techniques for SARS-CoV-2].
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| The ongoing epidemic of caused by the coronavirus SARS-CoV-2 starting in December 2019 poses a serious public health threat globally. The virus is highly infectious and transmitted mainly through droplets and contacts, and is associated with a high risk of pneumonia. A small number of patients may present with acute re... |
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The Promise of Aggregation-Induced Emission Luminogens for Detecting COVID-19
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| The long-term pandemic of coronavirus disease 2019 (COVID-19) requires sensitive and accurate diagnostic assays to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and SARS-CoV-2 antibodies in infected individuals. Currently, RNA of SARS-CoV-2 virus is mainly detected by reverse transcription-p... |
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SARS-CoV-2 and regular patient treatment – from the use of rapid antigen testing up to treatment specific precaution measures
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| INTRODUCTION: The COVID-19 pandemic poses a continued challenge for all parties involved especially for the dentist as routine operation must be resumed. Rapid Antigen Tests (RATs) are actually recommended to identify and minimize infectious risks. However, there is still no guideline on the implementation of RATs in a... |
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Paper-Based Biosensors for COVID-19: A Review of Innovative Tools for Controlling the Pandemic
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| [Image: see text] The appearance and quick spread of the new severe acute respiratory syndrome coronavirus disease, COVID-19, brought major societal challenges. Importantly, suitable medical diagnosis procedures and smooth clinical management of the disease are an emergent need, which must be anchored on novel diagnost... |
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COVID-19 Point-of-Care Diagnostics: Present and Future
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| [Image: see text] Point-of-care (POC) detection technologies that enable decentralized, rapid, sensitive, low-cost diagnostics of COVID-19 infection are urgently needed around the world. With many technologies approved for commercialization in the past 10 months, the field of COVID-19 POC diagnostics is rapidly evolvin... |
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SARS-CoV-2 serology testing: Progress and challenges
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| The coronavirus disease 2019 (COVID-19) pandemic has caused the most devasting social and economic impact of this century. The current pandemic will end only after a safe, effective vaccine becomes available and protective herd immunity has been achieved through vaccination. The key parameter to gauge protective immuni... |
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Comparison of nine different commercially available molecular assays for detection of SARS-CoV-2 RNA
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| To face the COVID-19 pandemic, the need for fast and reliable diagnostic assays for the detection of SARS-CoV-2 is immense. We describe our laboratory experiences evaluating nine commercially available real-time RT-PCR assays. We found that assays differed considerably in performance and validation before routine use i... |
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Assessing the COVID-19 diagnostic laboratory capacity in Indonesia in the early phase of the pandemic.
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| The coronavirus disease 2019 (COVID-19) pandemic has put a great burden on countries as a result of the demand for laboratory diagnostic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This paper reports our experiences in rapidly assessing Indonesia's COVID-19 laboratory testing capacity in t... |
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Diagnosis of COVID-19, vitality of emerging technologies and preventive measures
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| Coronavirus diseases-2019 (COVID-19) is becoming increasing serious and major threat to public health concerns. As a matter of fact, timely testing enhances the life-saving judgments on treatment and isolation of COVID-19 infected individuals at possible earliest stage which ultimately suppresses spread of infectious d... |
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'The Double-Edged Sword' - An hypothesis for Covid-19-induced salivary biomarkers
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| Utilising biomarkers for COVID-19 diagnosis, prediction of treatment response and overall prognostication have been investigated recently. However, these ventures have only considered the use of blood-based molecular markers. Saliva is another biofluid that warrants being applied in similar fashion with major advantage... |
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Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies: A Patent Review
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| The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disea... |
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Analysis of the positive rate of 4254 cases of COVID-19 nucleic acid tests in different aites in Wuhan, China
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| There's an outbreak of coronavirus diesase 2019 (COVID-19) since December 2019, first in Wuhan. It has caused huge medical challenges to Hubei Province with currently more than 67 thousand confirmed cases till 8th March 2020. Identification, there is no clinically effective drug. Isolation and masks are essential to li... |
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Development and application of sensitive, specific, and rapid CRISPR-Cas13-based diagnosis
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| Nucleic acid detection is a necessary part of medical treatment and fieldwork. However, the current detection technologies are far from ideal. A lack of timely and accessible testing for identifying cases and close contacts has allowed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative virus of... |
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Nano-layered surface plasmon resonance-based highly sensitive biosensor for virus detection: A theoretical approach to detect SARS-CoV-2
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| The outbreak of the coronavirus disease (COVID-19) pandemic has become a worldwide health catastrophe instigated by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Countries are battling to slow the spread of this virus by testing and treating patients, along with other measures such as prohibiting large ... |
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Paper-based devices for rapid diagnostics and testing sewage for early warning of COVID-19 outbreak
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| Coronavirus disease (COVID-19), caused by SARS-CoV-2, evolved into a global pandemic in 2020, and the outbreak has taken an enormous toll on individuals, families, communities and societies around the world. One practical and effective strategy is to implement rapid case identification based on a rapid testing to respo... |
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Serological differentiation between COVID-19 and SARS infections
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| In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by the SARS-CoV-2 virus, multiple diagnostic tests are required globally for acute disease diagnosis, contact tracing, monitoring of asymptomatic infection rates and assessing herd immunity. While PCR remains the frontline test of choice in the acu... |
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Navigating the Diagnostics of COVID-19
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| The recent outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Hubei province, China, in December 2019 and has spread worldwide at an alarming rate. With over eight million individuals infected and exceeding 400,000 deaths globally, the necessity to develop fast and efficient diagnosti... |
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Home Monitoring for Fever: An Inexpensive Screening Method to Prevent Household Spread of COVID-19
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| The COVID-19 pandemic surge has exceeded testing capacities in many parts of the world. We investigated the effectiveness of home temperature monitoring for early identification of COVID-19 patients. Study Design: We compared home temperature measurements from a convenience sample of 1180 individuals who reported being... |
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Laboratory-Based Resources for COVID-19 Diagnostics: Traditional Tools and Novel Technologies. A Perspective of Personalized Medicine
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| The coronavirus infection 2019 (COVID-19) pandemic, caused by the highly contagious SARS-CoV-2 virus, has provoked a global healthcare and economic crisis. The control over the spread of the disease requires an efficient and scalable laboratory-based strategy for testing the population based on multiple platforms to pr... |
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Symptoms and Characteristics Which Require Attention During COVID-19 Screening at a Port of Entry
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| BACKGROUND: The quarantine process at a country's port of entry has an important role in preventing an influx of coronavirus disease 2019 (COVID-19) cases from abroad and further minimizing the national healthcare burden of COVID-19. However, there has been little published on the process of COVID-19 screening among tr... |
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Clinical Application of the Standard Q COVID-19 Ag Test for the Detection of SARS-CoV-2 Infection
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| We evaluated the Standard Q COVID-19 Ag test for the diagnosis of coronavirus disease 2019 (COVID-19) compared to the reverse transcription-polymerase chain reaction (RT-PCR) test. We applied both tests to patients who were about to be hospitalized, had visited an emergency room, or had been admitted due to COVID-19 co... |
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Recurrence of SARS-CoV-2 nucleic acid positive test in patients with COVID-19: a report of two cases
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| BACKGROUND: The recurrence of positive SARS-CoV-2 nucleic acid test results in patients with COVID-19 is becoming more important and warrants more attention. CASE PRESENTATION: This study reports 2 cases, a child with mild COVID-19 and an adult female with moderate COVID-19, who were discharged after three consecutive ... |
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Serological and Molecular Tests for COVID-19: a recent update
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| The COVID-19 pandemic is probably the most devastating worldwide challenge in recent century. COVID-19 leads to a mild to severe respiratory disease and affects different organs and has become a global concern since December 2019. Meanwhile, molecular biology and diagnostic laboratories played an essential role in diag... |
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Rethinking Aptamers as Nanotheranostic Tools for SARS-COV-2 and COVID-19 Infection
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| The novel coronavirus named by WHO and Coronavirus Study Group (CSG) as SARS-COV-2 is the etiological agent of the newly emerged Coronavirus disease (COVID-19). COVID-19 has become a pandemic threat as the WHO declared it a public health emergency of international concern. Early and precise detection of the virus is im... |
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SARS-CoV-2 diagnostic testing alternatives for Latin America
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| In the past four months SARS-CoV-2 has reached most countries in the world. Public health strategies based on widespread testing and proper isolation of positive cases have shown to be helpful to reduce local transmission of SARS-CoV-2. Confirmatory tests, that identify viral RNA, and screening serological tests that i... |
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Positive RT-PCR in urine from an asymptomatic patient with novel coronavirus 2019 infection: a case report
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| Introduction: With the emergence of novel coronavirus disease 2019 (COVID-19) in many countries, medical resources currently focus on the treatment of confirmed patients and screening of suspected cases. Asymptomatic patients may be contagious, which makes epidemic control difficult. We describe an asymptomatic patient... |
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Patient safety recommendations and management in patients with COVID-19 pneumonia suspicion: a retrospective study
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| Objective: Since December 2019, new pneumonia of unknown aetiology broke out in Wuhan, Hubei province, China. Subsequently, a virus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the causative agent of the disease. Currently, the epidemic has spread all over the world. Th... |
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Laboratory Assay Evaluation Demystified: A Review of Key Factors Influencing Interpretation of Test Results Using Different Assays for SARS-CoV-2 Infection Diagnosis
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| Laboratory tests are an integral part of the diagnosis and management of patients; however, these tests are far from perfect. Their imperfections can be due to patient health condition, specimen collection, and/or technological difficulty with performing the assay and/or interpretation. To be useful clinically, testing... |
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Clinical evaluation of SARS-CoV-2 antigen-based rapid diagnostic test kit for detection of COVID-19 cases in Bangladesh
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| The rapid and early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is key to control the current Coronavirus disease 2019 (COVID-19) pandemic. The present study was conducted to clinically evaluate a rapid diagnostic test (RDT) kit, Standard Q COVID-19 Ag Test (SD Biosensor®, Repub... |
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Performance of Oropharyngeal Swab Testing Compared With Nasopharyngeal Swab Testing for Diagnosis of Coronavirus Disease 2019-United States, January 2020-February 2020.
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| Among 146 nasopharyngeal (NP) and oropharyngeal (OP) swab pairs collected ≤7 days after illness onset, Real-Time Reverse Transcriptase Polymerase Chain Reaction assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 RT-PCR) diagnostic results were 95.2% concordant. However, NP swab cycle threshold values... |
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SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility
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| The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-Co... |
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FNCas9 editor-linked uniform detection assay: An innovative COVID-19 sleuth
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| Relying on traditional diagnostic approaches like quantitative polymerase chain reaction is not appropriate for both time and cost in sudden outbreaks and pandemics such as COVID-19 In such cases, diagnostic approaches through rapid sequencing of pathogenic DNA and RNA are important for accelerated clinical prognosis F... |
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Laboratory organisation and management of SARS-CoV-2 infection in Niger, West Africa
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| BACKGROUND: As the coronavirus disease 2019 (COVID-19) pandemic unfolds, laboratory services have been identified as key to its containment. This article outlines the laboratory organisation and management and control interventions in Niger. INTERVENTION: The capitol city of Niger, Niamey, adopted a ‘National COVID-19 ... |
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Broad respiratory testing to identify SARS-CoV-2 viral co-circulation and inform diagnostic stewardship in the COVID-19 pandemic
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| Background: SARS-CoV-2 infection can present with a broad clinical differential that includes many other respiratory viruses;therefore, accurate tests are crucial to distinguish true COVID-19 cases from pathogens that do not require urgent public health interventions. Co-circulation of other respiratory viruses is larg... |
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Role and utility of COVID-19 laboratory testing in low-income and middle-income countries: protocol for rapid evidence synthesis
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| INTRODUCTION: Accurate and affordable laboratory testing is key to timely diagnosis and appropriate management of patients with COVID-19. New laboratory test protocols are released into the market under emergency use authorisation with limited evidence on diagnostic test accuracy. As such, robust evidence on the diagno... |
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Design and study of a coronavirus-shaped metamaterial sensor stimulated by electromagnetic waves for rapid diagnosis of covid-19
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| We propose a new technique of utilizing metamaterials-based sensor for rapid diagnosis of covid-19 through electromagnetic-stimulated analysis of the blood drawn from the patient. The sensor was inspired by a coronavirus in plane-shaped design with presume that its circular structure might produce a broader interaction... |
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Investigation of compatibility of severe acute respiratory syndrome coronavirus 2 reverse transcriptase-PCR kits containing different gene targets during coronavirus disease 2019 pandemic
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| AIM: In the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reverse transcriptase-PCR (RT-PCR) technique is often used. We evaluated the compatibility of SARS-CoV-2 RT-PCR kits containing different gene targets during the pandemic. MATERIALS & METHODS: Samples were tested by Bio-Speddy(®) (Rd... |
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Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform
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| The race towards the development of user-friendly, portable, fast-detection, and low-cost devices for healthcare systems has become the focus of effective screening efforts since the pandemic attack in December 2019, which is known as the coronavirus disease 2019 (COVID-19) pandemic. Currently existing techniques such ... |
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Point of care testing for detection of coronaviruses including SARS-CoV-2 from saliva without treating RNA in advance
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| Coronavirus disease 2019 (COVID-19) outbreak was reported to the WHO (World Health Organization) as an outbreak on end of 2019, afterwards pandemic on the worldwide in 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has be reported it to cause COVID-19, and highly transmissible. Therefore, it is impo... |
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Assessing the COVID-19 diagnostic laboratory capacity in Indonesia in the early phase of the pandemic
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| The coronavirus disease 2019 (COVID-19) pandemic has put a great burden on countries as a resultof the demand for laboratory diagnostic testing for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). This paper reports our experiences in rapidly assessing Indonesia’s COVID-19laboratory testing capacity in the ... |
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Testing for SARS‐CoV‐2: the day the world turned its attention to the clinical laboratory
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| In the last few months, an unprecedented number of laboratory tests for COVID‐19 have been developed at a remarkable speed. With the rapid adoption of these tests into clinical practice, combined with the widespread publicity they received, questions arose related to the different types of tests, their utility, perform... |
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COVID-19 infection in the palatine tonsil tissue and detritus: the detection of the virus compartment with RT-PCR
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| Two patients suffering from chronic recurrent tonsillitis were reported. The first patient was confirmed infected with COVID-19, 3 weeks prior to tonsillectomy. The detritus and tonsil specimen were further analysed through real-time PCR (RT-PCR) and revealed amplification of the fragment N and ORF1ab genes of SARS-CoV... |
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Antigen tests for COVID-19
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| PCR diagnosis has been considered as the gold standard for coronavirus disease 2019 (COVID-19) and other many diseases. However, there are many problems in using PCR, such as non-specific (i.e., false-positive) and false-negative amplifications, the limits of a target sample volume, deactivation of the enzymes used, co... |
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Analysis of the Clinical and Epidemiological Meaning of Screening Test for SARS-CoV-2: Considerations in the Chronic Kidney Disease Patients during the COVID-19 Pandemic
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| The COronaVIrus Disease 19 (COVID-19) pandemic is an emerging reality in nephrology. In a continuously changing scenario, we need to assess our patients’ additional risk in terms of attending hemodialysis treatments, follow-up peritoneal dialysis, and kidney transplant visits. The prevalence of severe acute respiratory... |
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Diagnosis options in patients suffering from COVID-19- like symptoms.
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| The role and performance of chest CT in the diagnosis of the coronavirus disease 2019 pandemic remains under active investigation. A recent case report in this journal found that a COVID-19 diagnosis has been made from the serological results despite first CT scan and RT-PCR negative results. We have included 311 conse... |
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Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic
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| Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the glo... |
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Utility of Point-of-Care COVID-19 Testing in an Outpatient Otolaryngology clinic
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| OBJECTIVE: To evaluate the utility of point-of-care COVID-19 testing for identifying infected patients in an otolaryngology practice. STUDY DESIGN: Retrospective review of 947 patients tested with a point-of-care nucleic acid amplification test for SARS-CoV-2 (Abbott ID Now). SETTING: Tertiary otolaryngology clinic set... |
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A comparative review of immunoassays for COVID-19 detection
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| INTRODUCTION: The gold standard for diagnosis of coronavirus disease 2019 (COVID-19) is detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription polymerase chain reaction (RT-PCR), which is expensive, time-consuming and may result in false-negative results. Serological tests can b... |
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Development of a Sensitive Immunochromatographic Method Using Lanthanide Fluorescent Microsphere for Rapid Serodiagnosis of COVID-19
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| [Image: see text] The SARS-CoV-2 infection that caused the COVID-19 pandemic quickly spread worldwide within two months. Rapid diagnosis of the disease and isolation of patients are effective ways to prevent and control the spread of COVID-19. Therefore, a sensitive immunofluorescent assay method was developed for rapi... |
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Detection of Microbial Agents in Oropharyngeal and Nasopharyngeal Samples of SARS-CoV-2 Patients
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| The novel coronavirus outbreak started in December 2019 and rapidly spread around the globe, leading to a global pandemic Here we reported the association of microbial agents identified in oropharyngeal and nasopharyngeal samples from patients with SARS-CoV-2 infection, using a Pan-microarray based technology referred ... |
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Combination of a SARS-CoV-2 IgG assay and RT-PCR for improved COVID-19 diagnosis
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| Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is generally diagnosed by reverse transcription (RT)-PCR or serological assays. The SARS-CoV-2 viral load decreases a few days after symptom onset. Thus, the RT-PCR sensitivity peaks at three days af... |
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Current and emerging diagnostic tests available for the novel COVID-19 global pandemic
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| On March 11, 2020 the World Health Organization (WHO) upgraded the status of the coronavirus disease 2019 (COVID-19) outbreak from epidemic to a global pandemic. This infection is caused by a novel coronavirus, SARS-CoV-2. Several rapid diagnostic tests have been developed at an astonishing pace; however, COVID-19 requ... |
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Testing for SARS-CoV-2 (COVID-19): A General Review.
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| The rampant COVID-19 pandemic has strained the testing capabilities of healthcare centers across the country. Several nucleic acid and serologic assays are available or currently being developed to meet the growing demand for large-scale testing. This review summarizes the developments of commonly used testing methods ... |
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False-negative RT-PCR in SARS-CoV-2 disease: experience from an Italian COVID-19 unit
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| False-negative cases of #COVID19 are being increasingly reported. Laboratory diagnosis through RT-PCR testing alone lacks adequate sensitivity to be recommended as the only valid criterion to confirm COVID-19 diagnosis. https://bit.ly/2BLFnEe |
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Issues of Random Sampling with Rapid Antigen Tests for COVID-19 Diagnosis: A Special Reference to Kalmunai RDHS Division
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| Random sampling from the community and performing the rapid antigen test has become a debatable issue during this COVID-19 pandemic. This writing analyzes the concerns using the data from Kalmunai RDHS Division, Sri Lanka, related to COVID-19 and shows the issues of random sampling in a community wherein the incident r... |
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Laboratory diagnosis of severe acute respiratory syndrome coronavirus 2
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| The first laboratory confirmed case of Coronavirus disease 2019 (COVID-19) in Australia was in Victoria on 25 January 2020 in a man returning from Wuhan city, Hubei province, the People's Republic of China. This was followed by three cases in New South Wales the following day. The Australian Government activated the Au... |
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Molecular Diagnosis of Severe Acute Respiratory Syndrome
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| The etiologic agent of severe acute respiratory syndrome (SARS) has been identified as a new type of coronavirus, known as SARS-coronavirus (SARS-CoV). Although the SARS epidemic has subsided, many authorities, including the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), have ... |
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Nucleic-acid-amplification tests from respiratory samples for the diagnosis of coronavirus infections: systematic review and meta-analysis
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| BACKGROUND: Management and control of COVID-19 relies on reliable diagnostic testing. OBJECTIVES: To evaluate the diagnostic test accuracy (DTA) of nucleic acid-amplification tests (NAAT) for the diagnosis of coronavirus infections. DATA SOURCES: PubMed, Web of Science, the Cochrane Library, Embase, Open Grey and confe... |
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The Role of Computed Tomography and Real-Time Polymerase Chain Reaction in the Diagnosis and Prognostication of COVID-19
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| With the rapid spread of coronavirus disease 2019 (COVID-19) starting in early 2020, there has been much interest in the applicability of radiologic imaging in managing affected patients From the initial screening to addressing the extent of pulmonary involvement, CT scans provide great value to hospitals overwhelmed b... |
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### Response:
Development of a Sensitive Immunochromatographic Method Using Lanthanide Fluorescent Microsphere for Rapid Serodiagnosis of COVID-19
### Response:
| The SARS-CoV-2 infection that caused the COVID-19 pandemic quickly spread worldwide within two months. Rapid diagnosis of the disease and isolation of patients are effective ways to prevent and control the spread of COVID-19. Therefore, a sensitive immunofluorescent assay method was developed for rapid detection of spe... |
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Please summerize the given abstract to a title
### Response:
Potential false-positive reasons for SARS-CoV-2 antibody testing and its solution
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| Coronavirus disease 2019 (COVID-19) has brought a huge impact on global health and the economy. Early diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is essential for epidemic prevention and control. The detection of SARS-CoV-2 antibodies is an important criterion for diagnosing COVI... |
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Targets and assay types for COVID-19 diagnosis.
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| The lack of complete information on the immune response dynamics to infection with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has led to the use of mainly molecular tests such as reverse transcription PCR (RT-PCR) to diagnose Coronavirus 2019 disease (COVID-19). Although remarkable progress has been m... |
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Expanding molecular diagnostic capacity for COVID-19 in Ethiopia: operational implications, challenges and lessons learnt
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| Efforts towards slowing down coronavirus (COVID-19) transmission and reducing mortality have focused on timely case detection, isolation and treatment. Availability of laboratory COVID-19 testing capacity using reverse-transcriptase polymerase chain reaction (RT-PCR) was essential for case detection. Hence, it was crit... |
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Swabbing Thoroughly People for COVID-19 Positivity. Insights on the Main Bio-analytical and Microbiology Bias and Concerns
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| Thorough swabbing is becoming an increasing approach to fight COVID-19 transmission, particularly among asymptomatic subjects, who are thought to represent the majority of potentially-contacting people. Particularly in the current management of COVID-19 emergency, the 3T approach, i.e., testing, tracing and treating, i... |
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The Impact of Increasing Disease Prevalence, False Omissions, and Diagnostic Uncertainty on Coronavirus Disease 2019 (COVID-19) Test Performance
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| CONTEXT.: Coronavirus disease 2019 (COVID-19) test performance depends on predictive values in settings of increasing disease prevalence. Geospatially distributed diagnostics with minimal uncertainty facilitate efficient point-of-need strategies. OBJECTIVES.: To use original mathematics to interpret COVID-19 test met... |
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Sensitivity and specificity of a covid-19 lateral flow immunoassay compared to rt-pcr in pregnant womenat arifin achmad general hospital pekanbaru, indonesia
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| Coronavirus disease 2019 (COVID-19) is significant global treat including to pregnant woman in Indonesia. A point-of-care diagnostic tool that is able to early diagnose and hasa good sensitivity and specificity is critical during the pandemic. The aim of this study was to describe the clinical, laboratory and outcomes ... |
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